MLF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.92735692
2Golgi transport vesicle coating (GO:0048200)5.92735692
3protein retention in ER lumen (GO:0006621)5.73604090
4synaptic vesicle maturation (GO:0016188)5.73471072
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.54554637
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.05376338
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.88096752
8protein maturation by protein folding (GO:0022417)4.56848448
9locomotory exploration behavior (GO:0035641)4.56257310
10proline biosynthetic process (GO:0006561)4.47697399
11retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.46564102
12positive regulation of synapse maturation (GO:0090129)4.35826469
13glutamate secretion (GO:0014047)4.30107234
14synaptic vesicle exocytosis (GO:0016079)4.29744331
15layer formation in cerebral cortex (GO:0021819)4.23898643
16regulation of synapse structural plasticity (GO:0051823)4.01102222
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.00674121
18regulation of early endosome to late endosome transport (GO:2000641)3.90456220
19synaptic vesicle docking involved in exocytosis (GO:0016081)3.86423080
20sodium ion export (GO:0071436)3.82860424
21NADH metabolic process (GO:0006734)3.81394398
22negative regulation of microtubule polymerization (GO:0031115)3.79407476
23regulation of synaptic vesicle exocytosis (GO:2000300)3.77451971
24vocalization behavior (GO:0071625)3.71529753
25cell migration in hindbrain (GO:0021535)3.67020798
26gluconeogenesis (GO:0006094)3.67011788
27cell communication by electrical coupling (GO:0010644)3.61894941
28neuromuscular process controlling posture (GO:0050884)3.54826606
29L-serine metabolic process (GO:0006563)3.54798028
30monosaccharide biosynthetic process (GO:0046364)3.51592034
31pentose-phosphate shunt (GO:0006098)3.51403995
32cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.49093384
33neuromuscular process controlling balance (GO:0050885)3.47944595
34regulation of neuronal synaptic plasticity (GO:0048168)3.47636888
35regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.47062589
36mitotic nuclear envelope reassembly (GO:0007084)3.46110914
37nuclear envelope reassembly (GO:0031468)3.46110914
38cerebellar Purkinje cell layer development (GO:0021680)3.46041113
39hexose biosynthetic process (GO:0019319)3.45832489
40neurotransmitter secretion (GO:0007269)3.44302477
41regulation of mammary gland epithelial cell proliferation (GO:0033599)3.41072958
42exploration behavior (GO:0035640)3.39956750
43regulation of synaptic vesicle transport (GO:1902803)3.38628609
44regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.38526638
45glycolytic process (GO:0006096)3.36448445
46NADPH regeneration (GO:0006740)3.35363546
47regulation of long-term neuronal synaptic plasticity (GO:0048169)3.35307804
48neuronal action potential propagation (GO:0019227)3.35052117
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.32854961
50negative regulation of cell size (GO:0045792)3.29460276
51CDP-diacylglycerol metabolic process (GO:0046341)3.28662814
52mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.27410681
53dendritic spine morphogenesis (GO:0060997)3.26084350
54proline metabolic process (GO:0006560)3.25434564
55negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.21298664
56cellular potassium ion homeostasis (GO:0030007)3.18545730
57activation of protein kinase A activity (GO:0034199)3.18444644
58regulation of glutamate receptor signaling pathway (GO:1900449)3.15929906
59GDP-mannose metabolic process (GO:0019673)3.15833362
60establishment of viral latency (GO:0019043)3.14213766
61cell-cell junction maintenance (GO:0045217)3.10139189
62protein localization to synapse (GO:0035418)3.08095838
63regulation of translational termination (GO:0006449)3.05371381
64establishment of integrated proviral latency (GO:0075713)3.03452379
65glucose catabolic process (GO:0006007)3.03436081
66positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.99831008
67barbed-end actin filament capping (GO:0051016)2.98461685
68oxaloacetate metabolic process (GO:0006107)2.97805175
69glucose 6-phosphate metabolic process (GO:0051156)2.96283512
704-hydroxyproline metabolic process (GO:0019471)2.95591524
71proline transport (GO:0015824)2.95293669
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.94007734
73nucleobase-containing small molecule interconversion (GO:0015949)2.91851420
74tricarboxylic acid cycle (GO:0006099)2.90459621
75tricarboxylic acid metabolic process (GO:0072350)2.85157092
76deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.83314966
77mitochondrion transport along microtubule (GO:0047497)2.82284427
78establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.82284427
79planar cell polarity pathway involved in neural tube closure (GO:0090179)2.80793759
80spliceosomal tri-snRNP complex assembly (GO:0000244)2.79321028
81adenine nucleotide transport (GO:0051503)2.77264832
82regulation of translational fidelity (GO:0006450)2.75658237
83protein complex localization (GO:0031503)2.75605636
84peptidyl-arginine omega-N-methylation (GO:0035247)2.75163086
85activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.74610129
86positive regulation of sodium ion transport (GO:0010765)2.72718971
87positive regulation of membrane potential (GO:0045838)2.71544758
88cell junction maintenance (GO:0034331)2.69321875
89regulation of dendritic spine morphogenesis (GO:0061001)2.69023770
90dendritic spine organization (GO:0097061)2.68882157
91amino acid import (GO:0043090)2.68616177
92CDP-diacylglycerol biosynthetic process (GO:0016024)2.68082986
93long-term memory (GO:0007616)2.67728598
94regulation of synaptic plasticity (GO:0048167)2.67502290
95regulation of sodium ion transmembrane transporter activity (GO:2000649)2.67429629
96regulation of synapse maturation (GO:0090128)2.67428919
97positive regulation of nuclease activity (GO:0032075)2.66671497
98vesicle coating (GO:0006901)2.65705075
99protein localization to endosome (GO:0036010)2.63313508
100regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.62286917
101histone arginine methylation (GO:0034969)2.61899933
102neurotransmitter transport (GO:0006836)2.61317229
103regulation of clathrin-mediated endocytosis (GO:2000369)2.61012824
104neuromuscular process (GO:0050905)2.59119902
105establishment of mitochondrion localization (GO:0051654)2.57333133
106cell communication involved in cardiac conduction (GO:0086065)2.56962745
107ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.56838682
108regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.56715698
109regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56067731
110ionotropic glutamate receptor signaling pathway (GO:0035235)2.55819040
111synaptic transmission, glutamatergic (GO:0035249)2.53979857
112regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.53209935
113positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.53209935
114maternal placenta development (GO:0001893)2.51884415
115lipopolysaccharide biosynthetic process (GO:0009103)2.51598257
116regulation of mitotic spindle organization (GO:0060236)2.51409494
117protein insertion into membrane (GO:0051205)2.51251337
118glutamine family amino acid biosynthetic process (GO:0009084)2.50200048
119prepulse inhibition (GO:0060134)2.49955540
120behavioral defense response (GO:0002209)2.49592288
121behavioral fear response (GO:0001662)2.49592288
122regulation of neurotransmitter levels (GO:0001505)2.49172552
123response to parathyroid hormone (GO:0071107)2.49025438
124organelle transport along microtubule (GO:0072384)2.48034129
125cellular protein complex localization (GO:0034629)2.47389614
126gamma-aminobutyric acid transport (GO:0015812)2.46083440
127positive regulation of dendritic spine development (GO:0060999)2.46046444
128glycine transport (GO:0015816)2.44499160
129peptidyl-arginine N-methylation (GO:0035246)2.44418922
130peptidyl-arginine methylation (GO:0018216)2.44418922
131dopamine receptor signaling pathway (GO:0007212)2.43410958
132lung-associated mesenchyme development (GO:0060484)2.42234083
133pyruvate metabolic process (GO:0006090)2.41562674
134G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.40735257
135cerebellar granule cell differentiation (GO:0021707)2.40695800
136regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.40418284
137de novo posttranslational protein folding (GO:0051084)2.40353545
138cellular sodium ion homeostasis (GO:0006883)2.39820996
139regulation of sodium ion transmembrane transport (GO:1902305)2.39261072
140synaptic vesicle endocytosis (GO:0048488)2.38865980
141membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.38091256
142response to pheromone (GO:0019236)2.38085463
143activation of Rac GTPase activity (GO:0032863)2.37813182
144adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.37811445
145adherens junction assembly (GO:0034333)2.37659282
146negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.37362267
147chemosensory behavior (GO:0007635)2.36753136
148plasma membrane repair (GO:0001778)2.36188112
149neuron-neuron synaptic transmission (GO:0007270)2.35399772
150neuron cell-cell adhesion (GO:0007158)2.35251441
151C4-dicarboxylate transport (GO:0015740)2.35188565
152positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.35180059
153negative regulation of potassium ion transmembrane transport (GO:1901380)2.34737170
154stress fiber assembly (GO:0043149)2.34633472
155peptidyl-proline hydroxylation (GO:0019511)2.34309714
156positive regulation of synaptic transmission, GABAergic (GO:0032230)2.34178985
157purine nucleotide transport (GO:0015865)2.33998545
158neuronal ion channel clustering (GO:0045161)2.33735475
159de novo protein folding (GO:0006458)2.33358575
160anterior/posterior axis specification, embryo (GO:0008595)2.33296199
161nucleoside diphosphate biosynthetic process (GO:0009133)2.33019420
162positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.32986381
163protein targeting to plasma membrane (GO:0072661)2.32640090
164regulation of cholesterol biosynthetic process (GO:0045540)2.31892978
165innervation (GO:0060384)2.31760204
166negative regulation of catenin import into nucleus (GO:0035414)2.31266026
167dendrite morphogenesis (GO:0048813)2.31168421
168mitochondrial fusion (GO:0008053)2.31110484
169endoplasmic reticulum unfolded protein response (GO:0030968)2.30122598
170regulation of nuclease activity (GO:0032069)2.27310738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.91733891
2ZFP281_18757296_ChIP-ChIP_E14_Mouse2.79779824
3ZNF263_19887448_ChIP-Seq_K562_Human2.73980450
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.67099272
5EZH2_22144423_ChIP-Seq_EOC_Human2.54026921
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.46267647
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.41882805
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.34605745
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.32650644
10ERG_21242973_ChIP-ChIP_JURKAT_Human2.29727602
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25618067
12CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.24487371
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20420025
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.12483787
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.08523574
16LXR_22292898_ChIP-Seq_THP-1_Human2.04797627
17THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97471303
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96846787
19MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96186717
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.95238455
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.95025340
22NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.94204020
23XRN2_22483619_ChIP-Seq_HELA_Human1.89529335
24KDM2B_26808549_Chip-Seq_K562_Human1.88594348
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.82442806
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.81810984
27* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.81179564
28ZFP281_27345836_Chip-Seq_ESCs_Mouse1.80494032
29DNAJC2_21179169_ChIP-ChIP_NT2_Human1.75921562
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75290009
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72648931
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72445703
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71755762
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.71658728
35REST_21632747_ChIP-Seq_MESCs_Mouse1.68912779
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67676684
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.62519861
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61706219
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.60593781
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60318702
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59663535
42RACK7_27058665_Chip-Seq_MCF-7_Human1.59165595
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57535999
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56993704
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56993704
46CLOCK_20551151_ChIP-Seq_293T_Human1.55449910
47* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55043412
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.53677650
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52763478
50KDM2B_26808549_Chip-Seq_DND41_Human1.49842424
51* CREB1_26743006_Chip-Seq_LNCaP_Human1.49802920
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48464699
53P68_20966046_ChIP-Seq_HELA_Human1.48036993
54* SMC4_20622854_ChIP-Seq_HELA_Human1.47848586
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47673018
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46322980
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.46201337
58VDR_21846776_ChIP-Seq_THP-1_Human1.44169826
59SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42781121
60* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40851826
61SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.40821416
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40007833
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37899631
64CTCF_27219007_Chip-Seq_Bcells_Human1.37135390
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37014007
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.36558511
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36488691
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36118117
69TET1_21490601_ChIP-Seq_MESCs_Mouse1.36079035
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.35458544
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35321388
72TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.34642351
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34575527
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34296569
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33707943
76MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33419972
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33365287
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32564239
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30491913
80* TET1_21451524_ChIP-Seq_MESCs_Mouse1.30291241
81* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.30095739
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.29879354
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29370902
84DCP1A_22483619_ChIP-Seq_HELA_Human1.29160693
85GABP_19822575_ChIP-Seq_HepG2_Human1.29038644
86MYC_22102868_ChIP-Seq_BL_Human1.29009685
87* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28849810
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28501698
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27861566
90* ATF3_27146783_Chip-Seq_COLON_Human1.27859267
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26995015
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.26829086
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25953221
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24287279
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24211462
96* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23859399
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23858610
98ETS1_20019798_ChIP-Seq_JURKAT_Human1.23714993
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23277495
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23277495
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23277495
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.23115647
103* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.23064160
104SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22841968
105* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22342841
106YY1_22570637_ChIP-Seq_MALME-3M_Human1.22039815
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22034983
108DROSHA_22980978_ChIP-Seq_HELA_Human1.21862529
109* FOXP1_21924763_ChIP-Seq_HESCs_Human1.21569791
110* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20177462
111NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.19584412
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18606110
113* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18169454
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17986015
115TP53_20018659_ChIP-ChIP_R1E_Mouse1.16908006
116* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15881813
117RNF2_27304074_Chip-Seq_ESCs_Mouse1.15032969
118SA1_27219007_Chip-Seq_ERYTHROID_Human1.14839110
119EZH2_27304074_Chip-Seq_ESCs_Mouse1.14663033
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13981285
121TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12722530
122* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12174885
123* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11516725
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11382591
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11334419
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11294190
127SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10153177
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09994198
129CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.09842722
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09596648
131MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09442243
132STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09426390
133TP53_22127205_ChIP-Seq_IMR90_Human1.09281156
134TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.08754983
135* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07845475
136KDM2B_26808549_Chip-Seq_JURKAT_Human1.07467417
137* RING1B_27294783_Chip-Seq_ESCs_Mouse1.07114296
138OCT4_19829295_ChIP-Seq_ESCs_Human1.06999444
139SA1_27219007_Chip-Seq_Bcells_Human1.06528756
140SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06282074
141CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06189552
142RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06096436
143RARA_24833708_ChIP-Seq_LIVER_Mouse1.05964327
144E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05700537
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05320760
146ELF1_20517297_ChIP-Seq_JURKAT_Human1.04706713
147TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04479543
148* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04307417
149* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.04248572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.56601408
2MP0004270_analgesia3.15511988
3MP0003635_abnormal_synaptic_transmissio3.11439785
4MP0004858_abnormal_nervous_system2.93443260
5MP0008260_abnormal_autophagy2.76799826
6MP0003329_amyloid_beta_deposits2.65024449
7MP0003880_abnormal_central_pattern2.58881889
8MP0002653_abnormal_ependyma_morphology2.51630392
9MP0002063_abnormal_learning/memory/cond2.43995611
10MP0005451_abnormal_body_composition2.29949033
11MP0002877_abnormal_melanocyte_morpholog2.18569544
12MP0002064_seizures2.15914129
13MP0002909_abnormal_adrenal_gland2.09900720
14MP0003283_abnormal_digestive_organ2.07901923
15MP0005058_abnormal_lysosome_morphology2.06670130
16MP0009745_abnormal_behavioral_response2.06204971
17MP0002822_catalepsy1.97752924
18MP0003705_abnormal_hypodermis_morpholog1.94489289
19MP0008438_abnormal_cutaneous_collagen1.93758545
20MP0009046_muscle_twitch1.87992024
21MP0000678_abnormal_parathyroid_gland1.87963512
22MP0002734_abnormal_mechanical_nocicepti1.86841012
23MP0002249_abnormal_larynx_morphology1.84450159
24MP0002572_abnormal_emotion/affect_behav1.75553713
25MP0002733_abnormal_thermal_nociception1.75289697
26MP0005423_abnormal_somatic_nervous1.71757369
27MP0004233_abnormal_muscle_weight1.65838257
28MP0004885_abnormal_endolymph1.64313126
29MP0003566_abnormal_cell_adhesion1.61888749
30MP0005257_abnormal_intraocular_pressure1.60757040
31MP0001968_abnormal_touch/_nociception1.60454757
32MP0008932_abnormal_embryonic_tissue1.59573593
33MP0001440_abnormal_grooming_behavior1.58816988
34MP0003123_paternal_imprinting1.58704121
35MP0000751_myopathy1.57975996
36MP0002272_abnormal_nervous_system1.57000230
37MP0000955_abnormal_spinal_cord1.56799960
38MP0005623_abnormal_meninges_morphology1.56403994
39MP0004811_abnormal_neuron_physiology1.52906853
40MP0000579_abnormal_nail_morphology1.52734784
41MP0001486_abnormal_startle_reflex1.49942198
42MP0009840_abnormal_foam_cell1.47893569
43MP0005501_abnormal_skin_physiology1.47369225
44MP0001970_abnormal_pain_threshold1.47312217
45MP0003119_abnormal_digestive_system1.46914847
46MP0009672_abnormal_birth_weight1.45030345
47MP0001346_abnormal_lacrimal_gland1.44870490
48MP0002184_abnormal_innervation1.41836198
49MP0008961_abnormal_basal_metabolism1.40684491
50MP0010030_abnormal_orbit_morphology1.40415315
51MP0000747_muscle_weakness1.39207089
52MP0004145_abnormal_muscle_electrophysio1.36266705
53MP0003693_abnormal_embryo_hatching1.35684667
54MP0003111_abnormal_nucleus_morphology1.31495695
55MP0003122_maternal_imprinting1.28464975
56MP0002796_impaired_skin_barrier1.27928869
57MP0003879_abnormal_hair_cell1.25129079
58MP0010234_abnormal_vibrissa_follicle1.24763290
59MP0002269_muscular_atrophy1.24573536
60MP0000778_abnormal_nervous_system1.24364563
61MP0000013_abnormal_adipose_tissue1.23243350
62MP0000467_abnormal_esophagus_morphology1.21941198
63MP0008569_lethality_at_weaning1.20455175
64MP0009053_abnormal_anal_canal1.19407447
65MP0002066_abnormal_motor_capabilities/c1.17168300
66MP0002882_abnormal_neuron_morphology1.16496903
67MP0009780_abnormal_chondrocyte_physiolo1.16245991
68MP0003137_abnormal_impulse_conducting1.15619995
69MP0004272_abnormal_basement_membrane1.15131052
70MP0002152_abnormal_brain_morphology1.12165924
71MP0000750_abnormal_muscle_regeneration1.11973525
72MP0002089_abnormal_postnatal_growth/wei1.11600284
73MP0003315_abnormal_perineum_morphology1.10661360
74MP0000534_abnormal_ureter_morphology1.09723847
75MP0001188_hyperpigmentation1.07409700
76MP0001849_ear_inflammation1.07166312
77MP0000566_synostosis1.07068697
78MP0000762_abnormal_tongue_morphology1.06903641
79MP0002067_abnormal_sensory_capabilities1.06386848
80MP0000537_abnormal_urethra_morphology1.06106713
81MP0002736_abnormal_nociception_after1.05425063
82MP0001501_abnormal_sleep_pattern1.03346352
83MP0005386_behavior/neurological_phenoty1.02415576
84MP0004924_abnormal_behavior1.02415576
85MP0002557_abnormal_social/conspecific_i1.02059405
86MP0005394_taste/olfaction_phenotype1.01209220
87MP0005499_abnormal_olfactory_system1.01209220
88MP0003646_muscle_fatigue0.99940812
89MP0003861_abnormal_nervous_system0.98442011
90MP0000681_abnormal_thyroid_gland0.98357783
91MP0000462_abnormal_digestive_system0.97232745
92MP0004043_abnormal_pH_regulation0.95627497
93MP0003942_abnormal_urinary_system0.93923291
94MP0003634_abnormal_glial_cell0.92678685
95MP0002234_abnormal_pharynx_morphology0.91568018
96MP0001730_embryonic_growth_arrest0.90283857
97MP0000604_amyloidosis0.90250665
98MP0000350_abnormal_cell_proliferation0.90165436
99MP0005330_cardiomyopathy0.89226162
100MP0002080_prenatal_lethality0.89098252
101MP0003385_abnormal_body_wall0.87295397
102MP0004087_abnormal_muscle_fiber0.85638412
103MP0003191_abnormal_cellular_cholesterol0.85049330
104MP0004142_abnormal_muscle_tone0.84734109
105MP0001348_abnormal_lacrimal_gland0.83456450
106MP0003186_abnormal_redox_activity0.83345508
107MP0004084_abnormal_cardiac_muscle0.82985847
108MP0002837_dystrophic_cardiac_calcinosis0.82517125
109MP0001905_abnormal_dopamine_level0.82221367
110MP0002060_abnormal_skin_morphology0.81154276
111MP0000003_abnormal_adipose_tissue0.80746525
112MP0002069_abnormal_eating/drinking_beha0.80676476
113MP0004215_abnormal_myocardial_fiber0.79622510
114MP0004185_abnormal_adipocyte_glucose0.79568288
115MP0000049_abnormal_middle_ear0.79400031
116MP0002735_abnormal_chemical_nociception0.79019131
117MP0000759_abnormal_skeletal_muscle0.78499382
118MP0000358_abnormal_cell_content/0.77451220
119MP0004085_abnormal_heartbeat0.76763239
120MP0003075_altered_response_to0.76615003
121MP0001502_abnormal_circadian_rhythm0.76215400
122MP0005187_abnormal_penis_morphology0.76198701
123MP0008872_abnormal_physiological_respon0.75568287
124MP0003077_abnormal_cell_cycle0.75372091
125MP0003221_abnormal_cardiomyocyte_apopto0.75299675
126MP0002084_abnormal_developmental_patter0.74350229
127MP0008789_abnormal_olfactory_epithelium0.73834566
128MP0005375_adipose_tissue_phenotype0.73746076
129MP0001529_abnormal_vocalization0.73520574
130MP0004957_abnormal_blastocyst_morpholog0.73374315
131MP0000920_abnormal_myelination0.73229516
132MP0009379_abnormal_foot_pigmentation0.72752245
133MP0003115_abnormal_respiratory_system0.72737010
134MP0008770_decreased_survivor_rate0.72437682
135MP0003633_abnormal_nervous_system0.71807679
136MP0002085_abnormal_embryonic_tissue0.70670842
137MP0006036_abnormal_mitochondrial_physio0.70411759
138MP0008874_decreased_physiological_sensi0.69983465
139MP0010771_integument_phenotype0.69346747
140MP0004133_heterotaxia0.68885303
141MP0003632_abnormal_nervous_system0.67299049
142MP0003631_nervous_system_phenotype0.66992876
143MP0006035_abnormal_mitochondrial_morpho0.66246604
144MP0002752_abnormal_somatic_nervous0.65304603
145MP0001299_abnormal_eye_distance/0.64989841
146MP0002229_neurodegeneration0.64929646
147MP0000428_abnormal_craniofacial_morphol0.63784679

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.22816468
2Abnormal gallbladder physiology (HP:0012438)4.27585622
3Cholecystitis (HP:0001082)4.27585622
4Abnormality of the lower motor neuron (HP:0002366)4.10286000
5Visual hallucinations (HP:0002367)3.68682499
6Abnormality of glycolysis (HP:0004366)3.43219238
7Ventricular fibrillation (HP:0001663)3.41401584
8Focal motor seizures (HP:0011153)3.33367935
9Focal seizures (HP:0007359)3.24609875
10Achilles tendon contracture (HP:0001771)3.24552988
11Vertebral compression fractures (HP:0002953)3.02413589
12Bundle branch block (HP:0011710)2.98756890
13Abnormality of the Achilles tendon (HP:0005109)2.97836411
14Ankle clonus (HP:0011448)2.88544549
15Supranuclear gaze palsy (HP:0000605)2.83563453
16Increased serum pyruvate (HP:0003542)2.77626075
17Upper limb amyotrophy (HP:0009129)2.69739181
18Distal upper limb amyotrophy (HP:0007149)2.69739181
19Difficulty climbing stairs (HP:0003551)2.68208222
20Cerebral hypomyelination (HP:0006808)2.62039801
21Long palpebral fissure (HP:0000637)2.57038096
22Annular pancreas (HP:0001734)2.53800315
23Delusions (HP:0000746)2.53144701
24Amyotrophic lateral sclerosis (HP:0007354)2.52788575
25Cerebral inclusion bodies (HP:0100314)2.48333791
26Hand muscle atrophy (HP:0009130)2.43436290
27Insomnia (HP:0100785)2.41344852
28Depression (HP:0000716)2.39124159
29Action tremor (HP:0002345)2.38894580
30Megalencephaly (HP:0001355)2.38492594
31Gout (HP:0001997)2.37377211
32Ragged-red muscle fibers (HP:0003200)2.35016941
33Distal lower limb amyotrophy (HP:0008944)2.28900357
34Neuronal loss in central nervous system (HP:0002529)2.26467592
35Lower limb amyotrophy (HP:0007210)2.26232716
36Stridor (HP:0010307)2.24539398
37Impaired social interactions (HP:0000735)2.23623009
38Abnormal social behavior (HP:0012433)2.23623009
39Centrally nucleated skeletal muscle fibers (HP:0003687)2.22803165
40Broad distal phalanx of finger (HP:0009836)2.21968377
41Microvesicular hepatic steatosis (HP:0001414)2.20916805
42Cholelithiasis (HP:0001081)2.19830685
43Trismus (HP:0000211)2.19277976
44Myopathic facies (HP:0002058)2.18514581
45Shoulder girdle muscle weakness (HP:0003547)2.13965086
46Hyperparathyroidism (HP:0000843)2.11977463
47Pointed chin (HP:0000307)2.11458675
48Tetraplegia (HP:0002445)2.11117919
49Torticollis (HP:0000473)2.11038018
50Atrioventricular block (HP:0001678)2.10546249
51Neurofibrillary tangles (HP:0002185)2.09205735
52Atonic seizures (HP:0010819)2.07763935
53Rapidly progressive (HP:0003678)2.07184611
54Upper limb muscle weakness (HP:0003484)2.06512632
55Distal lower limb muscle weakness (HP:0009053)2.05814665
56Athetosis (HP:0002305)2.05462198
57Epileptic encephalopathy (HP:0200134)2.05183956
58Hypercortisolism (HP:0001578)2.04409276
59Amblyopia (HP:0000646)2.04128562
60Multiple enchondromatosis (HP:0005701)2.03510739
61Bronchomalacia (HP:0002780)2.03192638
62Mutism (HP:0002300)2.02921006
63Ulnar bowing (HP:0003031)2.02481731
64Generalized tonic-clonic seizures (HP:0002069)2.02301353
65Absence seizures (HP:0002121)2.02252847
66Peripheral hypomyelination (HP:0007182)2.02136594
67Angiofibromas (HP:0010615)2.01841836
68Adenoma sebaceum (HP:0009720)2.01841836
69Dialeptic seizures (HP:0011146)2.01719382
70Poor eye contact (HP:0000817)2.01302212
71Difficulty running (HP:0009046)2.00784004
72Ependymoma (HP:0002888)2.00212302
73Neoplasm of the heart (HP:0100544)1.99613288
74Abnormality of the umbilical cord (HP:0010881)1.95776855
75Growth hormone excess (HP:0000845)1.95407094
76Neoplasm of the peripheral nervous system (HP:0100007)1.93392586
77Hammertoe (HP:0001765)1.93252353
78Abnormal eating behavior (HP:0100738)1.93047230
79Focal dystonia (HP:0004373)1.92442034
80Progressive muscle weakness (HP:0003323)1.92378168
81Nuclear cataract (HP:0100018)1.92239808
82Termporal pattern (HP:0011008)1.92065221
83Insidious onset (HP:0003587)1.92065221
84Shallow orbits (HP:0000586)1.91399114
85Abnormal atrioventricular conduction (HP:0005150)1.91068219
86Abnormal gallbladder morphology (HP:0012437)1.90765347
87Urinary urgency (HP:0000012)1.90630854
88Restlessness (HP:0000711)1.90341634
89Obstructive sleep apnea (HP:0002870)1.90231227
90Heart block (HP:0012722)1.90219788
91Dysdiadochokinesis (HP:0002075)1.89971112
92Status epilepticus (HP:0002133)1.89833503
93Back pain (HP:0003418)1.89529941
94Apathy (HP:0000741)1.89506996
95Deep palmar crease (HP:0006191)1.89037768
96Spinal rigidity (HP:0003306)1.88065114
97Turricephaly (HP:0000262)1.86725190
98Sudden death (HP:0001699)1.85879511
99Pheochromocytoma (HP:0002666)1.84609427
100Genu recurvatum (HP:0002816)1.84137397
101Overriding aorta (HP:0002623)1.83729949
102Abnormality of the astrocytes (HP:0100707)1.83305589
103Astrocytoma (HP:0009592)1.83305589
104Impaired vibration sensation in the lower limbs (HP:0002166)1.82514586
105Cortical dysplasia (HP:0002539)1.82227407
106Protrusio acetabuli (HP:0003179)1.81252200
107Diminished motivation (HP:0000745)1.81015880
108Abnormal neuron morphology (HP:0012757)1.80292799
109Abnormality of the motor neurons (HP:0002450)1.80292799
110Distal sensory impairment (HP:0002936)1.79694905
111Anxiety (HP:0000739)1.79455725
112Dysmetria (HP:0001310)1.78910180
113Truncus arteriosus (HP:0001660)1.78227172
114Hemiparesis (HP:0001269)1.77432734
115Global brain atrophy (HP:0002283)1.77388908
116Atrophy/Degeneration involving motor neurons (HP:0007373)1.77128845
117Abnormality of the distal phalanges of the toes (HP:0010182)1.77091304
118Resting tremor (HP:0002322)1.76794218
119Hyperthyroidism (HP:0000836)1.75333444
120Clonus (HP:0002169)1.74449523
121Pelvic girdle muscle weakness (HP:0003749)1.74382720
122Ankle contracture (HP:0006466)1.74310000
123Abnormality of the gallbladder (HP:0005264)1.74013104
124Testicular atrophy (HP:0000029)1.73990619
125Craniofacial dystonia (HP:0012179)1.73656477
126Progressive cerebellar ataxia (HP:0002073)1.73512563
127Hemiplegia (HP:0002301)1.72353693
128Hypokinesia (HP:0002375)1.72276081
129Short nail (HP:0001799)1.71632395
130Heterochromia iridis (HP:0001100)1.71624571
131Spastic gait (HP:0002064)1.71150970
132Abnormality of dentin (HP:0010299)1.70892123
133Premature rupture of membranes (HP:0001788)1.70375567
134Reticulocytosis (HP:0001923)1.70323201
135Ventricular arrhythmia (HP:0004308)1.69667532
136Myotonia (HP:0002486)1.69144195
137Impaired pain sensation (HP:0007328)1.69114549
138Abnormality of pain sensation (HP:0010832)1.69114549
139Muscle fiber splitting (HP:0003555)1.68685458
140Rough bone trabeculation (HP:0100670)1.66918271
141Selective tooth agenesis (HP:0001592)1.66745396
142Fragile skin (HP:0001030)1.66498701
143Biconcave vertebral bodies (HP:0004586)1.66215947
144Generalized hypotonia (HP:0001290)1.65527207
145Fasciculations (HP:0002380)1.65279243
146Unilateral renal agenesis (HP:0000122)1.65048289
147Abnormality of the musculature of the pelvis (HP:0001469)1.64695947
148Abnormality of the hip-girdle musculature (HP:0001445)1.64695947
149Abnormality of aromatic amino acid family metabolism (HP:0004338)1.64636384
150Hyperacusis (HP:0010780)1.64539502
151Foot dorsiflexor weakness (HP:0009027)1.64029136
152Mildly elevated creatine phosphokinase (HP:0008180)1.63870455
153Microretrognathia (HP:0000308)1.63040470
154Muscle stiffness (HP:0003552)1.62031369
155Generalized amyotrophy (HP:0003700)1.61985949
156Spastic diplegia (HP:0001264)1.61043628
157Cervical subluxation (HP:0003308)1.60361032
158Hypercalcemia (HP:0003072)1.60158378
159Increased connective tissue (HP:0009025)1.59871571
160Emotional lability (HP:0000712)1.59705221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.98817765
2KSR22.99808555
3EPHA42.93337507
4TRIB32.90124052
5NME22.75786746
6PAK62.67575371
7SMG12.64490505
8LATS22.62151637
9PRKD32.51318228
10NEK12.43849997
11NTRK32.28607557
12MARK12.19998234
13NTRK12.19868982
14TESK22.16240599
15VRK22.14581445
16MINK12.08612647
17ARAF2.04513070
18TYRO31.93759699
19TAOK11.82539083
20CAMKK11.80306644
21PRPF4B1.76753545
22KSR11.76245776
23SIK11.64877605
24BUB11.62426593
25DAPK21.60678260
26PIM21.57387293
27PBK1.48768713
28STK381.42597361
29IRAK31.35921008
30EPHA21.33114933
31SCYL21.32407452
32GRK51.30661064
33LIMK11.28494849
34PHKG21.26438938
35PHKG11.26438938
36ALK1.21915101
37LMTK21.21636842
38NTRK21.21213537
39PAK31.19261750
40MAP3K41.18419475
41SIK31.16902833
42PKN21.16395531
43CDK141.15379094
44UHMK11.12448540
45DDR21.11165405
46CDK151.09916120
47CDK181.05923868
48ICK1.05619882
49CDK51.03582209
50MAP2K41.02775537
51TESK11.02516397
52RAF11.01996234
53CDK11A1.00559371
54PDGFRA0.99791579
55MAP3K20.99387804
56DAPK30.91765823
57CAMKK20.90340905
58CDK120.88033107
59RIPK10.87019702
60DAPK10.85792319
61PNCK0.84490614
62PTK20.83682823
63BRAF0.83468843
64PRKCG0.83249934
65CDK190.82735125
66CSNK1G30.81212618
67PINK10.80546595
68LRRK20.80410421
69BRSK10.79441422
70MAP2K10.79284543
71FER0.78030537
72EPHB10.77765272
73EIF2AK10.76630419
74CDK70.74874835
75ABL20.74741617
76MOS0.72207710
77CSNK1A1L0.71035528
78PRKD20.69148558
79RET0.68960496
80ERN10.68893433
81MAP3K110.68590450
82MAP3K30.65715452
83PDK20.65707020
84DMPK0.65556856
85SIK20.65396499
86PAK10.64655813
87BMX0.64453591
88STK110.64003714
89MST1R0.62814837
90SRPK10.61662788
91MARK20.61645455
92AURKA0.61052617
93DYRK1B0.60667153
94PRKCI0.58543704
95ERBB40.58155399
96FGFR40.57306347
97RPS6KA20.55678806
98MAP2K20.55382346
99PTK60.54681860
100NME10.54664939
101KDR0.54617054
102PDPK10.54303619
103PAK40.54184580
104CSNK1E0.53972060
105PDK40.53936068
106PDK30.53936068
107MAP3K10.52843170
108ILK0.52476037
109PRKG20.52145258
110ROCK20.51046973
111BCKDK0.50835609
112TTN0.50473753
113AKT30.50404218
114PRKCZ0.46308498
115AKT20.45652680
116CAMK10.45558741
117MAP3K80.44758622
118MAPKAPK30.44672911
119EPHB20.42996075
120MAP2K70.42962740
121TTK0.42854992
122NEK20.42404831
123MET0.42369224
124CAMK2G0.42083784
125MTOR0.40573817
126CDK90.39487091
127EEF2K0.38639990
128MAP3K120.37793606
129MAPK100.37572714
130PAK20.37498434
131IRAK20.37070586
132CAMK2B0.36367949
133CDC42BPA0.35845608
134TAOK20.34907521
135CAMK2A0.34846203
136CSNK1G20.34626402
137PDK10.32877622

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.03723243
2Synaptic vesicle cycle_Homo sapiens_hsa047212.97832552
3Nitrogen metabolism_Homo sapiens_hsa009102.49672796
4Pentose phosphate pathway_Homo sapiens_hsa000302.38532552
5Long-term potentiation_Homo sapiens_hsa047202.07148635
6GABAergic synapse_Homo sapiens_hsa047271.97607311
7Vitamin B6 metabolism_Homo sapiens_hsa007501.93155105
8Nicotine addiction_Homo sapiens_hsa050331.93013637
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85656196
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.84086524
11Olfactory transduction_Homo sapiens_hsa047401.79538848
12Fatty acid elongation_Homo sapiens_hsa000621.76060073
13Circadian entrainment_Homo sapiens_hsa047131.72497632
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70056294
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68881412
16Amphetamine addiction_Homo sapiens_hsa050311.66951784
17Glutamatergic synapse_Homo sapiens_hsa047241.66857444
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65064689
19Dopaminergic synapse_Homo sapiens_hsa047281.64971979
20Base excision repair_Homo sapiens_hsa034101.56957424
21Arginine and proline metabolism_Homo sapiens_hsa003301.54302354
22Gap junction_Homo sapiens_hsa045401.52870403
23Insulin secretion_Homo sapiens_hsa049111.52827906
24Proteasome_Homo sapiens_hsa030501.52292980
25Oocyte meiosis_Homo sapiens_hsa041141.51726925
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45069236
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44323490
28Gastric acid secretion_Homo sapiens_hsa049711.44224624
29GnRH signaling pathway_Homo sapiens_hsa049121.44056601
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43413496
31Salivary secretion_Homo sapiens_hsa049701.42613355
32Phenylalanine metabolism_Homo sapiens_hsa003601.42198110
33Pyruvate metabolism_Homo sapiens_hsa006201.40490660
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37262888
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35657305
36Oxytocin signaling pathway_Homo sapiens_hsa049211.35639124
37Cholinergic synapse_Homo sapiens_hsa047251.33343962
38Glioma_Homo sapiens_hsa052141.29706113
39mTOR signaling pathway_Homo sapiens_hsa041501.27933530
40DNA replication_Homo sapiens_hsa030301.27492538
41Morphine addiction_Homo sapiens_hsa050321.27291203
42Folate biosynthesis_Homo sapiens_hsa007901.23782130
43Cardiac muscle contraction_Homo sapiens_hsa042601.23564006
44Long-term depression_Homo sapiens_hsa047301.21877383
45Cocaine addiction_Homo sapiens_hsa050301.19582169
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18732345
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17296131
48Estrogen signaling pathway_Homo sapiens_hsa049151.16958626
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15808235
50Biosynthesis of amino acids_Homo sapiens_hsa012301.15068728
51Melanogenesis_Homo sapiens_hsa049161.10256496
52VEGF signaling pathway_Homo sapiens_hsa043701.06630389
53Bladder cancer_Homo sapiens_hsa052191.03846720
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03494759
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.02887440
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01076904
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99108034
58Hippo signaling pathway_Homo sapiens_hsa043900.98463938
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96111216
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95067055
61Tight junction_Homo sapiens_hsa045300.95031138
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.94556053
63Fructose and mannose metabolism_Homo sapiens_hsa000510.93792121
64ErbB signaling pathway_Homo sapiens_hsa040120.93070925
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.92794599
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89722711
67Carbon metabolism_Homo sapiens_hsa012000.87971569
68Spliceosome_Homo sapiens_hsa030400.87620044
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.87582085
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86267281
71Dilated cardiomyopathy_Homo sapiens_hsa054140.85870696
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84971326
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83076984
74Other glycan degradation_Homo sapiens_hsa005110.82402127
75Renin secretion_Homo sapiens_hsa049240.81639933
76Renal cell carcinoma_Homo sapiens_hsa052110.81373641
77Calcium signaling pathway_Homo sapiens_hsa040200.80823339
78Prion diseases_Homo sapiens_hsa050200.79810147
79Insulin signaling pathway_Homo sapiens_hsa049100.79711743
80Endocytosis_Homo sapiens_hsa041440.79371498
81Hedgehog signaling pathway_Homo sapiens_hsa043400.79351223
82Axon guidance_Homo sapiens_hsa043600.78665731
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78519747
84Arginine biosynthesis_Homo sapiens_hsa002200.78471487
85Bile secretion_Homo sapiens_hsa049760.77323612
86cAMP signaling pathway_Homo sapiens_hsa040240.76313638
87N-Glycan biosynthesis_Homo sapiens_hsa005100.75067086
88Pyrimidine metabolism_Homo sapiens_hsa002400.74398721
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74286078
90Taste transduction_Homo sapiens_hsa047420.74070153
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73107103
92Butanoate metabolism_Homo sapiens_hsa006500.72868493
93Shigellosis_Homo sapiens_hsa051310.72019366
94Thyroid cancer_Homo sapiens_hsa052160.71524937
95Endometrial cancer_Homo sapiens_hsa052130.71159113
96Vibrio cholerae infection_Homo sapiens_hsa051100.69904381
97Choline metabolism in cancer_Homo sapiens_hsa052310.69894165
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69791168
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.69484571
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68955486
101Serotonergic synapse_Homo sapiens_hsa047260.68259275
102Fatty acid metabolism_Homo sapiens_hsa012120.67801622
103Collecting duct acid secretion_Homo sapiens_hsa049660.67696975
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.67405584
105Steroid biosynthesis_Homo sapiens_hsa001000.67196615
106AMPK signaling pathway_Homo sapiens_hsa041520.67159402
107Glucagon signaling pathway_Homo sapiens_hsa049220.66013733
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65190066
109Type II diabetes mellitus_Homo sapiens_hsa049300.64857507
110Non-small cell lung cancer_Homo sapiens_hsa052230.63735740
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.63369027
112Parkinsons disease_Homo sapiens_hsa050120.63208158
113Sulfur relay system_Homo sapiens_hsa041220.62173130
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61975611
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.60901953
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60582169
117Chronic myeloid leukemia_Homo sapiens_hsa052200.60158197
118Notch signaling pathway_Homo sapiens_hsa043300.59719940
119Glutathione metabolism_Homo sapiens_hsa004800.59570980
120Rap1 signaling pathway_Homo sapiens_hsa040150.58475696
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57989875
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57612408
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57350982
124Tyrosine metabolism_Homo sapiens_hsa003500.56812147
125Regulation of autophagy_Homo sapiens_hsa041400.55789919
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53109424
127Thyroid hormone synthesis_Homo sapiens_hsa049180.51876645
128Huntingtons disease_Homo sapiens_hsa050160.50884839
129Dorso-ventral axis formation_Homo sapiens_hsa043200.50544487
130Oxidative phosphorylation_Homo sapiens_hsa001900.49853910
131mRNA surveillance pathway_Homo sapiens_hsa030150.49327579
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48681476
133Wnt signaling pathway_Homo sapiens_hsa043100.47522794
134Alzheimers disease_Homo sapiens_hsa050100.47064130
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46833627
136Salmonella infection_Homo sapiens_hsa051320.46351283
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46150246
138Galactose metabolism_Homo sapiens_hsa000520.45809951
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42956174
140Cell cycle_Homo sapiens_hsa041100.38250903
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37075426
142Lysosome_Homo sapiens_hsa041420.34254638
143Metabolic pathways_Homo sapiens_hsa011000.32610594
144beta-Alanine metabolism_Homo sapiens_hsa004100.32471445
145Mismatch repair_Homo sapiens_hsa034300.32133102
146Adherens junction_Homo sapiens_hsa045200.28867025

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