MLH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.47479907
2DNA strand elongation involved in DNA replication (GO:0006271)5.27049462
3telomere maintenance via semi-conservative replication (GO:0032201)5.07643451
4DNA strand elongation (GO:0022616)5.00749012
5DNA replication initiation (GO:0006270)4.81969784
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.63518844
7DNA ligation (GO:0006266)4.61820872
8protein localization to kinetochore (GO:0034501)4.55527617
9telomere maintenance via recombination (GO:0000722)4.54644055
10DNA double-strand break processing (GO:0000729)4.47095527
11* synapsis (GO:0007129)4.44155818
12mitotic recombination (GO:0006312)4.43994143
13ribosomal small subunit assembly (GO:0000028)4.43858137
14nucleobase biosynthetic process (GO:0046112)4.01654169
15* non-recombinational repair (GO:0000726)4.01494265
16* double-strand break repair via nonhomologous end joining (GO:0006303)4.01494265
17CENP-A containing nucleosome assembly (GO:0034080)3.95774247
18nucleotide-excision repair, DNA gap filling (GO:0006297)3.95450438
19formation of translation preinitiation complex (GO:0001731)3.95268297
20purine nucleobase biosynthetic process (GO:0009113)3.93955947
21protein localization to chromosome, centromeric region (GO:0071459)3.93534274
22telomere maintenance via telomere lengthening (GO:0010833)3.92855477
23folic acid-containing compound biosynthetic process (GO:0009396)3.91334667
24establishment of viral latency (GO:0019043)3.88513185
25chromatin remodeling at centromere (GO:0031055)3.87273150
26IMP biosynthetic process (GO:0006188)3.83694344
27viral transcription (GO:0019083)3.82565222
28mitotic nuclear envelope disassembly (GO:0007077)3.82397420
29mitotic spindle checkpoint (GO:0071174)3.77612320
30DNA deamination (GO:0045006)3.77202980
31spindle checkpoint (GO:0031577)3.75996050
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74728094
33translational termination (GO:0006415)3.74054829
34attachment of spindle microtubules to kinetochore (GO:0008608)3.70515658
35DNA replication-dependent nucleosome organization (GO:0034723)3.67916849
36DNA replication-dependent nucleosome assembly (GO:0006335)3.67916849
37negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.67098550
38negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.67098550
39negative regulation of mitotic sister chromatid segregation (GO:0033048)3.67098550
40negative regulation of mitotic sister chromatid separation (GO:2000816)3.67098550
41negative regulation of sister chromatid segregation (GO:0033046)3.67098550
42kinetochore organization (GO:0051383)3.66895989
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66482404
44DNA replication checkpoint (GO:0000076)3.65432966
45negative regulation of chromosome segregation (GO:0051985)3.64096014
46* resolution of meiotic recombination intermediates (GO:0000712)3.63535683
47DNA replication-independent nucleosome assembly (GO:0006336)3.62588912
48DNA replication-independent nucleosome organization (GO:0034724)3.62588912
49DNA duplex unwinding (GO:0032508)3.60600132
50maturation of SSU-rRNA (GO:0030490)3.60456941
51mitotic spindle assembly checkpoint (GO:0007094)3.60169746
52DNA geometric change (GO:0032392)3.59365781
53regulation of spindle organization (GO:0090224)3.59359886
54regulation of DNA endoreduplication (GO:0032875)3.58060963
55DNA catabolic process, exonucleolytic (GO:0000738)3.57962164
56proteasome assembly (GO:0043248)3.56744000
57IMP metabolic process (GO:0046040)3.56419323
58spindle assembly checkpoint (GO:0071173)3.55294474
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.53818988
60mitotic metaphase plate congression (GO:0007080)3.49947200
61nuclear envelope disassembly (GO:0051081)3.49493004
62membrane disassembly (GO:0030397)3.49493004
63regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.49251375
64regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.49165350
65regulation of mitotic metaphase/anaphase transition (GO:0030071)3.49165350
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48263190
67translational elongation (GO:0006414)3.46349902
68regulation of chromosome segregation (GO:0051983)3.42403828
69negative regulation of ligase activity (GO:0051352)3.41022637
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41022637
71regulation of centriole replication (GO:0046599)3.40999883
72regulation of mitotic sister chromatid separation (GO:0010965)3.39882557
73regulation of mitotic sister chromatid segregation (GO:0033047)3.39882557
74regulation of sister chromatid segregation (GO:0033045)3.39882557
75regulation of mitotic spindle checkpoint (GO:1903504)3.39717336
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.39717336
77nuclear pore organization (GO:0006999)3.38639452
78regulation of histone H3-K9 methylation (GO:0051570)3.34204258
79pore complex assembly (GO:0046931)3.34153244
80* metaphase plate congression (GO:0051310)3.33946024
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.30218966
82ribosomal large subunit biogenesis (GO:0042273)3.28016411
83mitotic chromosome condensation (GO:0007076)3.27305818
84tRNA aminoacylation for protein translation (GO:0006418)3.24667775
85telomere maintenance (GO:0000723)3.24611057
86telomere organization (GO:0032200)3.23549608
87regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23266754
88translational initiation (GO:0006413)3.23019282
89translesion synthesis (GO:0019985)3.22028365
90nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.21207421
91negative regulation of DNA-dependent DNA replication (GO:2000104)3.20818480
92cotranslational protein targeting to membrane (GO:0006613)3.19928368
93amino acid activation (GO:0043038)3.18462330
94tRNA aminoacylation (GO:0043039)3.18462330
95protein targeting to ER (GO:0045047)3.17986275
96nuclear pore complex assembly (GO:0051292)3.16173136
97negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.15112313
98histone exchange (GO:0043486)3.13590983
99deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.12780642
100positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.11031136
101cullin deneddylation (GO:0010388)3.10946580
102ribonucleoprotein complex biogenesis (GO:0022613)3.10410287
103negative regulation of RNA splicing (GO:0033119)3.09583534
104kinetochore assembly (GO:0051382)3.09528822
105ribosomal small subunit biogenesis (GO:0042274)3.08999847
106* meiotic chromosome segregation (GO:0045132)3.08919888
107regulation of mitochondrial translation (GO:0070129)3.07152790
108establishment of integrated proviral latency (GO:0075713)3.05932098
109ribosome assembly (GO:0042255)3.05515870
110ribosome biogenesis (GO:0042254)3.05471417
111protein deneddylation (GO:0000338)3.04220772
112positive regulation of ligase activity (GO:0051351)3.03244981
113* establishment of chromosome localization (GO:0051303)3.02193024
114establishment of protein localization to endoplasmic reticulum (GO:0072599)3.01495169
115viral mRNA export from host cell nucleus (GO:0046784)3.01169896
116regulation of centrosome cycle (GO:0046605)3.00874834
117pseudouridine synthesis (GO:0001522)3.00522694
118mitotic sister chromatid segregation (GO:0000070)3.00148608
119DNA conformation change (GO:0071103)2.99482866
120postreplication repair (GO:0006301)2.98250201
121protein localization to endoplasmic reticulum (GO:0070972)2.97438055
122regulation of helicase activity (GO:0051095)2.96764941
123microtubule depolymerization (GO:0007019)2.96365769
124signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96105072
125signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96105072
126signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96105072
127replication fork processing (GO:0031297)2.95917857
128sister chromatid segregation (GO:0000819)2.94150606
129signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.94018980
130intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.94018980
131establishment of protein localization to mitochondrial membrane (GO:0090151)2.93968767
132regulation of ubiquitin-protein transferase activity (GO:0051438)2.93715108
133chromatin assembly or disassembly (GO:0006333)2.93065400
134DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.92886959
135base-excision repair (GO:0006284)2.90728993
136viral life cycle (GO:0019058)2.89752597
137regulation of mitotic spindle organization (GO:0060236)2.89689195
138negative regulation of histone methylation (GO:0031061)2.88315052
139DNA topological change (GO:0006265)2.88097872
140rRNA processing (GO:0006364)2.85663323
141cellular protein complex disassembly (GO:0043624)2.85313875
142* mismatch repair (GO:0006298)2.82976665
143* somatic hypermutation of immunoglobulin genes (GO:0016446)2.82952112
144* somatic diversification of immune receptors via somatic mutation (GO:0002566)2.82952112
145histone H2A acetylation (GO:0043968)2.81644042
146transcription-coupled nucleotide-excision repair (GO:0006283)2.81142799
147mitotic sister chromatid cohesion (GO:0007064)2.77409070
148rRNA metabolic process (GO:0016072)2.76857812
149protein localization to chromosome (GO:0034502)2.74319305
150positive regulation of chromosome segregation (GO:0051984)2.74265764
151snRNA processing (GO:0016180)2.73347839
152intra-S DNA damage checkpoint (GO:0031573)2.72742466
153* nuclear-transcribed mRNA catabolic process (GO:0000956)2.72697833
154negative regulation of mRNA processing (GO:0050686)2.72177732
155pteridine-containing compound biosynthetic process (GO:0042559)2.71655100
156ATP-dependent chromatin remodeling (GO:0043044)2.69380342
157DNA synthesis involved in DNA repair (GO:0000731)2.68954684
158spliceosomal snRNP assembly (GO:0000387)2.68805606

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.32108170
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.05342228
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.98332874
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.69464905
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.64437702
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04797422
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.60961137
8* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60042078
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59784842
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58902096
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58877165
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.39578187
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31402013
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.29156167
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27375120
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.24915444
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.24891191
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20823930
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18743827
20XRN2_22483619_ChIP-Seq_HELA_Human2.18352736
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15269025
22AR_21909140_ChIP-Seq_LNCAP_Human2.11926752
23* VDR_23849224_ChIP-Seq_CD4+_Human2.08241507
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07750357
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.04639983
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95316419
27FOXP3_21729870_ChIP-Seq_TREG_Human1.94491629
28MYC_22102868_ChIP-Seq_BL_Human1.90130159
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89156641
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85854013
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82131795
32* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74268510
33DCP1A_22483619_ChIP-Seq_HELA_Human1.72020702
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68532023
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66377583
36* CIITA_25753668_ChIP-Seq_RAJI_Human1.66142974
37GABP_19822575_ChIP-Seq_HepG2_Human1.66037735
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64727123
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60130998
40TTF2_22483619_ChIP-Seq_HELA_Human1.59227054
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58855661
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58321938
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56511967
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56340696
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55379110
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52592079
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51847327
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51574116
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51370152
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50846882
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50611363
52* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49918445
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48986926
54VDR_21846776_ChIP-Seq_THP-1_Human1.47472715
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45470064
56* ELK1_19687146_ChIP-ChIP_HELA_Human1.44830204
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43059617
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40872373
59ZNF274_21170338_ChIP-Seq_K562_Hela1.40381806
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.34612890
61KDM5A_27292631_Chip-Seq_BREAST_Human1.33226974
62EWS_26573619_Chip-Seq_HEK293_Human1.33190208
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.31470089
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28972830
65GATA1_22025678_ChIP-Seq_K562_Human1.28494902
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28487490
67* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27932338
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25579256
69* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23169643
70SCL_19346495_ChIP-Seq_HPC-7_Human1.21509339
71* SPI1_23547873_ChIP-Seq_NB4_Human1.19514337
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19038583
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18638044
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.16354796
75* NANOG_16153702_ChIP-ChIP_HESCs_Human1.16251421
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16161626
77* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12249096
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11970446
79TFEB_21752829_ChIP-Seq_HELA_Human1.08181287
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06641199
81* SOX2_16153702_ChIP-ChIP_HESCs_Human1.06637922
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06549757
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.05712330
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05703187
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05675054
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05201940
87IGF1R_20145208_ChIP-Seq_DFB_Human1.04802791
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04614852
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04355206
90SOX17_20123909_ChIP-Seq_XEN_Mouse1.03197532
91FUS_26573619_Chip-Seq_HEK293_Human1.02173323
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01666652
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00916616
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00020282
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99729977
96MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98650696
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96198127
98IRF1_19129219_ChIP-ChIP_H3396_Human0.95575014
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95003122
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93215754
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93172839
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92995438
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92944372
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91925094
105* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91377112
106VDR_22108803_ChIP-Seq_LS180_Human0.90477372
107GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88653278
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87717579
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87229415
110MYC_18940864_ChIP-ChIP_HL60_Human0.86126246
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83512072
112UTX_26944678_Chip-Seq_JUKART_Human0.82700609
113FLI1_27457419_Chip-Seq_LIVER_Mouse0.82601528
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82511774
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82036366
116MYB_26560356_Chip-Seq_TH1_Human0.80574482
117MYB_26560356_Chip-Seq_TH2_Human0.79798848
118ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78850969
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77492352
120* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.68545011
121PCGF2_27294783_Chip-Seq_ESCs_Mouse0.67196658
122GATA4_21415370_ChIP-Seq_HL-1_Mouse0.65820777
123* SALL4_22934838_ChIP-ChIP_CD34+_Human0.65703476
124ZFP57_27257070_Chip-Seq_ESCs_Mouse0.64892833
125ELK1_22589737_ChIP-Seq_MCF10A_Human0.64586984
126NANOG_21062744_ChIP-ChIP_HESCs_Human0.64263333
127CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.63784321
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.63679966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.79732456
2MP0010094_abnormal_chromosome_stability4.30926709
3MP0003077_abnormal_cell_cycle3.81379358
4MP0003111_abnormal_nucleus_morphology3.79657479
5MP0004957_abnormal_blastocyst_morpholog3.72503697
6MP0008057_abnormal_DNA_replication3.62799155
7MP0002396_abnormal_hematopoietic_system3.46363969
8MP0008058_abnormal_DNA_repair3.19448955
9MP0008007_abnormal_cellular_replicative2.73791075
10MP0001529_abnormal_vocalization2.18432034
11MP0010352_gastrointestinal_tract_polyps2.18344394
12MP0008932_abnormal_embryonic_tissue2.11871308
13MP0003806_abnormal_nucleotide_metabolis2.09995392
14MP0001730_embryonic_growth_arrest2.05054364
15MP0004808_abnormal_hematopoietic_stem2.04611027
16MP0002837_dystrophic_cardiac_calcinosis2.01960649
17MP0000350_abnormal_cell_proliferation1.95747354
18MP0003941_abnormal_skin_development1.88803667
19MP0000490_abnormal_crypts_of1.85503101
20MP0010307_abnormal_tumor_latency1.82360337
21MP0008877_abnormal_DNA_methylation1.80161005
22MP0006035_abnormal_mitochondrial_morpho1.75672728
23MP0003567_abnormal_fetal_cardiomyocyte1.73913890
24MP0006072_abnormal_retinal_apoptosis1.71671649
25MP0003763_abnormal_thymus_physiology1.69314928
26MP0008789_abnormal_olfactory_epithelium1.62568776
27MP0003123_paternal_imprinting1.59629036
28MP0008995_early_reproductive_senescence1.55394114
29MP0005380_embryogenesis_phenotype1.53938772
30MP0001672_abnormal_embryogenesis/_devel1.53938772
31MP0006054_spinal_hemorrhage1.53523287
32MP0005397_hematopoietic_system_phenotyp1.53441282
33MP0001545_abnormal_hematopoietic_system1.53441282
34MP0001984_abnormal_olfaction1.51463787
35MP0002398_abnormal_bone_marrow1.50003650
36MP0001697_abnormal_embryo_size1.49399369
37MP0002102_abnormal_ear_morphology1.49079790
38MP0003984_embryonic_growth_retardation1.47146385
39MP0004215_abnormal_myocardial_fiber1.46663483
40MP0003122_maternal_imprinting1.46256594
41* MP0002080_prenatal_lethality1.45260189
42MP0004145_abnormal_muscle_electrophysio1.44690855
43* MP0000313_abnormal_cell_death1.44671492
44* MP0002019_abnormal_tumor_incidence1.44167124
45* MP0001929_abnormal_gametogenesis1.44069898
46MP0002088_abnormal_embryonic_growth/wei1.43926610
47MP0000685_abnormal_immune_system1.42906203
48MP0000749_muscle_degeneration1.35206318
49MP0000703_abnormal_thymus_morphology1.34845171
50MP0002722_abnormal_immune_system1.34683667
51MP0003786_premature_aging1.34592070
52MP0002086_abnormal_extraembryonic_tissu1.34552626
53MP0000689_abnormal_spleen_morphology1.30502736
54MP0001293_anophthalmia1.28273202
55MP0001835_abnormal_antigen_presentation1.27469128
56MP0004197_abnormal_fetal_growth/weight/1.26906901
57MP0002166_altered_tumor_susceptibility1.25942804
58MP0005394_taste/olfaction_phenotype1.23780094
59MP0005499_abnormal_olfactory_system1.23780094
60MP0000372_irregular_coat_pigmentation1.19994107
61MP0002429_abnormal_blood_cell1.19449879
62MP0002085_abnormal_embryonic_tissue1.18344290
63MP0002084_abnormal_developmental_patter1.17155230
64MP0010030_abnormal_orbit_morphology1.16777886
65* MP0000653_abnormal_sex_gland1.14046434
66MP0004147_increased_porphyrin_level1.13757797
67MP0002163_abnormal_gland_morphology1.13418076
68MP0003937_abnormal_limbs/digits/tail_de1.13313848
69MP0003787_abnormal_imprinting1.10875276
70MP0000716_abnormal_immune_system1.09415173
71MP0001800_abnormal_humoral_immune1.08832124
72MP0009333_abnormal_splenocyte_physiolog1.07880198
73MP0000465_gastrointestinal_hemorrhage1.07542505
74MP0009703_decreased_birth_body1.05804068
75MP0004084_abnormal_cardiac_muscle1.05096755
76MP0005075_abnormal_melanosome_morpholog1.03418811
77MP0003121_genomic_imprinting1.01566898
78MP0005671_abnormal_response_to1.00069252
79MP0001286_abnormal_eye_development1.00055981
80MP0005174_abnormal_tail_pigmentation0.98921973
81MP0005076_abnormal_cell_differentiation0.98898346
82MP0002233_abnormal_nose_morphology0.98327446
83MP0005464_abnormal_platelet_physiology0.95718185
84MP0005253_abnormal_eye_physiology0.95620779
85MP0003890_abnormal_embryonic-extraembry0.95257884
86MP0005023_abnormal_wound_healing0.94810827
87MP0002420_abnormal_adaptive_immunity0.94224387
88MP0002095_abnormal_skin_pigmentation0.92291164
89MP0005379_endocrine/exocrine_gland_phen0.92170717
90MP0001819_abnormal_immune_cell0.91545315
91MP0004264_abnormal_extraembryonic_tissu0.91412823
92MP0002452_abnormal_antigen_presenting0.91056816
93MP0003646_muscle_fatigue0.90135365
94MP0002006_tumorigenesis0.90073497
95MP0003943_abnormal_hepatobiliary_system0.89623721
96* MP0003698_abnormal_male_reproductive0.88096923
97MP0003656_abnormal_erythrocyte_physiolo0.88009535
98MP0005330_cardiomyopathy0.86134949
99* MP0001119_abnormal_female_reproductive0.85973990
100MP0002269_muscular_atrophy0.83310937
101MP0002697_abnormal_eye_size0.82654571
102MP0002723_abnormal_immune_serum0.81791672
103MP0010155_abnormal_intestine_physiology0.81319315
104MP0003950_abnormal_plasma_membrane0.81102950
105MP0002132_abnormal_respiratory_system0.80619215
106MP0001661_extended_life_span0.80115877
107MP0001853_heart_inflammation0.79243521
108MP0009672_abnormal_birth_weight0.78314833
109MP0000358_abnormal_cell_content/0.77613117
110MP0009053_abnormal_anal_canal0.77376023
111MP0002405_respiratory_system_inflammati0.77147582
112MP0000858_altered_metastatic_potential0.77003186
113MP0003315_abnormal_perineum_morphology0.76436671
114* MP0002210_abnormal_sex_determination0.75382561
115MP0005408_hypopigmentation0.75261709
116MP0001299_abnormal_eye_distance/0.74845316
117MP0005083_abnormal_biliary_tract0.74839825
118MP0006036_abnormal_mitochondrial_physio0.74135041
119MP0003186_abnormal_redox_activity0.74020911
120MP0005391_vision/eye_phenotype0.74002943
121MP0005395_other_phenotype0.73908765
122MP0002075_abnormal_coat/hair_pigmentati0.73261413
123MP0000598_abnormal_liver_morphology0.71880310
124MP0005220_abnormal_exocrine_pancreas0.71724220
125MP0000569_abnormal_digit_pigmentation0.71286048
126MP0001915_intracranial_hemorrhage0.71100656
127MP0005384_cellular_phenotype0.70213304
128MP0002092_abnormal_eye_morphology0.70213228
129MP0000477_abnormal_intestine_morphology0.70113072
130MP0002938_white_spotting0.69769835
131MP0005025_abnormal_response_to0.69360868
132MP0006292_abnormal_olfactory_placode0.69330824
133* MP0001145_abnormal_male_reproductive0.69237930
134MP0003221_abnormal_cardiomyocyte_apopto0.67375799
135MP0002751_abnormal_autonomic_nervous0.66689841
136MP0009278_abnormal_bone_marrow0.65789198
137MP0003436_decreased_susceptibility_to0.65124131
138MP0002111_abnormal_tail_morphology0.64801475
139MP0003861_abnormal_nervous_system0.64470777
140MP0003755_abnormal_palate_morphology0.63784779
141MP0009697_abnormal_copulation0.63611055
142MP0005621_abnormal_cell_physiology0.63392632
143MP0003119_abnormal_digestive_system0.62904854
144* MP0002161_abnormal_fertility/fecundity0.62033967
145MP0003718_maternal_effect0.60580542
146MP0001764_abnormal_homeostasis0.60491883
147MP0002254_reproductive_system_inflammat0.60276085
148MP0002234_abnormal_pharynx_morphology0.60243873
149MP0001243_abnormal_dermal_layer0.59899601
150MP0000647_abnormal_sebaceous_gland0.59509402
151MP0003866_abnormal_defecation0.58697739
152MP0002160_abnormal_reproductive_system0.58466536
153MP0001727_abnormal_embryo_implantation0.57326582

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.52209901
2Abnormal number of erythroid precursors (HP:0012131)4.49113603
3Reticulocytopenia (HP:0001896)4.21079908
4Abnormality of the labia minora (HP:0012880)3.94157569
5Birth length less than 3rd percentile (HP:0003561)3.93691301
6Cortical dysplasia (HP:0002539)3.65792560
7Aplastic anemia (HP:0001915)3.60992437
8* Colon cancer (HP:0003003)3.60535633
9Acute necrotizing encephalopathy (HP:0006965)3.60391032
10Acute encephalopathy (HP:0006846)3.47180477
11Chromsome breakage (HP:0040012)3.44405570
12Thrombocytosis (HP:0001894)3.44325083
13Abnormality of chromosome stability (HP:0003220)3.28172936
14Oral leukoplakia (HP:0002745)3.26630436
15Abnormal mitochondria in muscle tissue (HP:0008316)3.23279125
16Increased serum pyruvate (HP:0003542)3.22506178
17Selective tooth agenesis (HP:0001592)3.13246614
18Progressive macrocephaly (HP:0004481)3.04941917
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.02886046
20Abnormality of glycolysis (HP:0004366)2.99865961
21Myelodysplasia (HP:0002863)2.96371313
22* Medulloblastoma (HP:0002885)2.87016738
23Increased CSF lactate (HP:0002490)2.86480190
24Meckel diverticulum (HP:0002245)2.84901621
25Cerebral edema (HP:0002181)2.83542401
26Abnormality of the preputium (HP:0100587)2.82875247
27Abnormality of methionine metabolism (HP:0010901)2.82434581
28Pallor (HP:0000980)2.77964678
29Hepatic necrosis (HP:0002605)2.74708578
30Abnormality of the ileum (HP:0001549)2.73879083
31Nephroblastoma (Wilms tumor) (HP:0002667)2.67761286
32Mitochondrial inheritance (HP:0001427)2.66857249
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.64676500
34Macrocytic anemia (HP:0001972)2.64435730
35IgM deficiency (HP:0002850)2.62185504
36Hepatocellular necrosis (HP:0001404)2.61184113
37Abnormality of the heme biosynthetic pathway (HP:0010472)2.57795983
38Absent thumb (HP:0009777)2.57092310
39High pitched voice (HP:0001620)2.55881892
40Embryonal renal neoplasm (HP:0011794)2.53275599
41Hypoplastic pelvis (HP:0008839)2.49040924
42* Basal cell carcinoma (HP:0002671)2.48878477
43* Ependymoma (HP:0002888)2.46099019
44Neoplasm of the adrenal gland (HP:0100631)2.44721738
4511 pairs of ribs (HP:0000878)2.43002020
46Abnormal number of incisors (HP:0011064)2.41214344
47Breast hypoplasia (HP:0003187)2.41042236
48Duodenal stenosis (HP:0100867)2.38396697
49Small intestinal stenosis (HP:0012848)2.38396697
50Bone marrow hypocellularity (HP:0005528)2.34463580
51Type I transferrin isoform profile (HP:0003642)2.34021812
52* Lymphoma (HP:0002665)2.33969881
53Increased hepatocellular lipid droplets (HP:0006565)2.33113264
54Prominent nose (HP:0000448)2.29388164
55Abnormality of the anterior horn cell (HP:0006802)2.28139516
56Degeneration of anterior horn cells (HP:0002398)2.28139516
57Poikiloderma (HP:0001029)2.28038795
58* Agnosia (HP:0010524)2.27880246
59Premature graying of hair (HP:0002216)2.26399707
60Patellar aplasia (HP:0006443)2.26263618
61Carpal bone hypoplasia (HP:0001498)2.24433137
62Elevated erythrocyte sedimentation rate (HP:0003565)2.23372062
63Abnormality of the fingertips (HP:0001211)2.23305306
64Petechiae (HP:0000967)2.22534309
65Acute myeloid leukemia (HP:0004808)2.21030400
66Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20180586
67* Neoplasm of the pancreas (HP:0002894)2.18391857
68Methylmalonic acidemia (HP:0002912)2.17745559
69Sloping forehead (HP:0000340)2.16338217
70Ectopic kidney (HP:0000086)2.15549403
71Abnormality of reticulocytes (HP:0004312)2.14937239
72Reduced antithrombin III activity (HP:0001976)2.14287166
73Rough bone trabeculation (HP:0100670)2.12486007
74Hypoplasia of the capital femoral epiphysis (HP:0003090)2.12377799
75Volvulus (HP:0002580)2.12071398
76* Amaurosis fugax (HP:0100576)2.12013353
77Abnormality of the carotid arteries (HP:0005344)2.11359382
78Increased serum lactate (HP:0002151)2.11139055
79Lactic acidosis (HP:0003128)2.11004235
80Cellular immunodeficiency (HP:0005374)2.09958348
81Abnormal hair whorl (HP:0010721)2.09201471
82Squamous cell carcinoma (HP:0002860)2.08660934
83Microretrognathia (HP:0000308)2.08116978
84Abnormality of the duodenum (HP:0002246)2.07649925
85Abnormality of pyrimidine metabolism (HP:0004353)2.07403789
86Increased nuchal translucency (HP:0010880)2.06882639
87Lipid accumulation in hepatocytes (HP:0006561)2.06555002
88Multiple enchondromatosis (HP:0005701)2.04654619
89Impulsivity (HP:0100710)2.03607407
90Gonadotropin excess (HP:0000837)2.03283058
91Clubbing of toes (HP:0100760)2.03197742
92Aplasia/Hypoplasia of the patella (HP:0006498)2.02553369
93Hyperglycinemia (HP:0002154)2.02116071
94* Neoplasm of the colon (HP:0100273)1.99912037
95Proximal placement of thumb (HP:0009623)1.99846587
96Hypoglycemic coma (HP:0001325)1.98968181
97Rimmed vacuoles (HP:0003805)1.98750954
98Pancytopenia (HP:0001876)1.98019545
99Postnatal microcephaly (HP:0005484)1.97109312
100* Cafe-au-lait spot (HP:0000957)1.96631072
101Exercise-induced muscle cramps (HP:0003710)1.94599918
102* Rhabdomyosarcoma (HP:0002859)1.93141477
103Long eyelashes (HP:0000527)1.92616073
104Pancreatic islet-cell hyperplasia (HP:0004510)1.91730038
105Exercise intolerance (HP:0003546)1.91637702
106Deviation of the thumb (HP:0009603)1.89580580
107Tubulointerstitial nephritis (HP:0001970)1.89400478
108Horseshoe kidney (HP:0000085)1.89275608
109Neoplasm of the adrenal cortex (HP:0100641)1.88773154
110Respiratory failure (HP:0002878)1.88673727
111Tracheoesophageal fistula (HP:0002575)1.88333895
112Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86318417
113Shoulder girdle muscle weakness (HP:0003547)1.84504947
114Abnormal lung lobation (HP:0002101)1.84235717
115Abnormal gallbladder physiology (HP:0012438)1.83817618
116Cholecystitis (HP:0001082)1.83817618
117B lymphocytopenia (HP:0010976)1.83727229
118Abnormality of B cell number (HP:0010975)1.83727229
119Aplasia/Hypoplasia of the sternum (HP:0006714)1.82699027
120Cerebral hypomyelination (HP:0006808)1.82115788
121Leukodystrophy (HP:0002415)1.81716014
122Abnormality of serum amino acid levels (HP:0003112)1.81485217
123Microvesicular hepatic steatosis (HP:0001414)1.78298484
124Abnormality of DNA repair (HP:0003254)1.75278550
125Abnormal protein N-linked glycosylation (HP:0012347)1.74246552
126Abnormal protein glycosylation (HP:0012346)1.74246552
127Abnormal glycosylation (HP:0012345)1.74246552
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74246552
129Atresia of the external auditory canal (HP:0000413)1.73340980
130Overlapping toe (HP:0001845)1.72106400
131* Ovarian neoplasm (HP:0100615)1.71930269
132Hyperglycinuria (HP:0003108)1.70653057
133Absent radius (HP:0003974)1.69749908
134Secondary amenorrhea (HP:0000869)1.69703656
135Intestinal atresia (HP:0011100)1.69421766
136Abnormality of T cells (HP:0002843)1.69326498
137Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68744513
138Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.68744513
139Small hand (HP:0200055)1.68511841
140Triphalangeal thumb (HP:0001199)1.68158355
141Renal cortical cysts (HP:0000803)1.67748843
142Optic nerve coloboma (HP:0000588)1.66974317
143Short 4th metacarpal (HP:0010044)1.66557656
144Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66557656
145Abnormality of glycine metabolism (HP:0010895)1.66113313
146Abnormality of serine family amino acid metabolism (HP:0010894)1.66113313
147Optic disc pallor (HP:0000543)1.66080228
148Methylmalonic aciduria (HP:0012120)1.66079464
149Acute lymphatic leukemia (HP:0006721)1.65366203
150Leukopenia (HP:0001882)1.65070412
151Abnormality of cells of the lymphoid lineage (HP:0012140)1.64580093
152Asplenia (HP:0001746)1.64466975
153Prominent metopic ridge (HP:0005487)1.63761672
154Aplasia/Hypoplasia of the thymus (HP:0010515)1.63535015
155Choanal atresia (HP:0000453)1.62841119
156Lethargy (HP:0001254)1.62756059
157Broad palm (HP:0001169)1.62723775
158Panhypogammaglobulinemia (HP:0003139)1.62110534
159* Neoplasm of the rectum (HP:0100743)1.60891730
160* Glioma (HP:0009733)1.60638226

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.22333442
2WEE13.79780733
3VRK23.60306439
4BUB13.31746261
5PBK3.05880711
6NEK22.64897535
7EIF2AK12.42314532
8PASK2.32710570
9STK102.28638203
10TAF12.23907482
11MST42.13456955
12ACVR1B2.11986159
13FLT32.03362194
14MAP4K12.02177567
15VRK12.02035897
16MAP3K102.00951360
17SRPK11.97135720
18TRIM281.93363585
19NEK11.93033027
20TTK1.90215462
21EIF2AK31.89775062
22BRSK21.88858404
23TSSK61.88646311
24PNCK1.88390648
25CDK71.81965947
26TGFBR11.81039236
27ATR1.80620260
28SCYL21.76557021
29NUAK11.74891010
30PLK11.71978869
31STK161.70244190
32AURKB1.68178299
33CDK121.64836718
34EEF2K1.62450997
35MAP3K41.59297222
36RPS6KB21.58960293
37NME21.56231550
38STK41.50378591
39MAP2K31.49829897
40BMPR1B1.48868797
41MKNK11.45757062
42BCR1.41008461
43WNK31.40647091
44RPS6KA41.39773266
45PDK21.39246983
46PKN21.39130116
47MAP3K81.33311241
48TLK11.32367783
49MAP2K71.32324986
50PLK41.31614859
51CDK41.28266160
52DYRK31.26563073
53LRRK21.24488098
54CHEK21.24157410
55PLK31.18788781
56BTK1.15180718
57NME11.13714145
58CHEK11.11817860
59PLK21.11569528
60CCNB11.10763950
61ERBB31.08645689
62BRSK11.06713923
63AURKA1.05176151
64ZAP701.04829855
65PAK41.04405935
66TESK21.03004863
67KIT0.95077160
68CSNK1G10.94328431
69MAP2K60.91590001
70OBSCN0.90791742
71PIM10.90003210
72ATM0.89762614
73ZAK0.89452226
74CDK60.87902157
75FRK0.82178505
76KDR0.81913825
77TEC0.79141754
78CSNK1G30.78160282
79CSF1R0.76869054
80JAK30.76306938
81CDK20.75672756
82CSNK1G20.72663773
83EIF2AK20.71974497
84TNIK0.68760600
85MAP3K60.68407462
86CDK80.67945986
87DYRK20.67889833
88MAP4K20.66552732
89TYK20.65115960
90CSNK2A20.63017131
91NEK90.62109482
92CSNK1A1L0.59858206
93STK30.57707806
94CDK10.56298980
95CSNK2A10.55419302
96FGFR20.55233160
97MKNK20.55183662
98MAPKAPK50.54027111
99CDK190.53961942
100MELK0.53442704
101PIM20.51815590
102CLK10.51233267
103ERN10.50966747
104TXK0.50125214
105BCKDK0.49253898
106BLK0.48894498
107BRD40.48281043
108SYK0.48162565
109MAPK110.47680228
110CAMK1G0.46955517
111LYN0.45305614
112MINK10.45107413
113PAK10.44753054
114MTOR0.43358643
115ERBB40.43100081
116MARK30.42940629
117ADRBK20.41869490
118PRKCI0.40545728
119CSNK1E0.40344563
120LCK0.38414871
121PRKDC0.37767893
122RPS6KA50.36623504
123ALK0.35539504
124TGFBR20.35537128
125IRAK40.35409596
126MAP3K110.35145094
127STK240.34169931
128SMG10.32220651
129MAPKAPK20.31917109
130FGFR10.31667120
131BRAF0.31560163
132PAK20.31128261
133CDK180.30813623
134MATK0.30783113
135GRK60.30539484
136YES10.29687045
137ITK0.29471234
138PAK30.29458190
139PRKACB0.29291566
140CDK140.28720854
141IKBKB0.25615622
142KSR10.24381771
143CDK150.24141398
144CDK11A0.22989386
145CDK30.20980061
146AKT20.17841152
147LIMK10.17276120

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.49813798
2* Mismatch repair_Homo sapiens_hsa034304.60265024
3Base excision repair_Homo sapiens_hsa034103.34837378
4Ribosome_Homo sapiens_hsa030103.18391935
5Homologous recombination_Homo sapiens_hsa034403.00517191
6Spliceosome_Homo sapiens_hsa030403.00306402
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.92256743
8Nucleotide excision repair_Homo sapiens_hsa034202.91016500
9One carbon pool by folate_Homo sapiens_hsa006702.86085572
10RNA transport_Homo sapiens_hsa030132.62047470
11Cell cycle_Homo sapiens_hsa041102.53083501
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.50190477
13RNA polymerase_Homo sapiens_hsa030202.35163091
14Proteasome_Homo sapiens_hsa030502.26552334
15Pyrimidine metabolism_Homo sapiens_hsa002402.24122300
16Non-homologous end-joining_Homo sapiens_hsa034502.20554293
17* Fanconi anemia pathway_Homo sapiens_hsa034602.11705165
18Propanoate metabolism_Homo sapiens_hsa006402.10637311
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.09872272
20Oxidative phosphorylation_Homo sapiens_hsa001901.94591397
21Parkinsons disease_Homo sapiens_hsa050121.88078136
22Steroid biosynthesis_Homo sapiens_hsa001001.80768765
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71527847
24RNA degradation_Homo sapiens_hsa030181.70483767
25Fatty acid elongation_Homo sapiens_hsa000621.53967337
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50125563
27Basal transcription factors_Homo sapiens_hsa030221.47119913
28Huntingtons disease_Homo sapiens_hsa050161.39903578
29mRNA surveillance pathway_Homo sapiens_hsa030151.34114852
30p53 signaling pathway_Homo sapiens_hsa041151.31618679
31Systemic lupus erythematosus_Homo sapiens_hsa053221.30847960
32Selenocompound metabolism_Homo sapiens_hsa004501.28821706
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.23425670
34Folate biosynthesis_Homo sapiens_hsa007901.18940545
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.15623341
36Sulfur relay system_Homo sapiens_hsa041221.13846529
37Antigen processing and presentation_Homo sapiens_hsa046121.11599412
38Purine metabolism_Homo sapiens_hsa002301.10993442
39Biosynthesis of amino acids_Homo sapiens_hsa012301.05711905
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.02120885
41Epstein-Barr virus infection_Homo sapiens_hsa051691.01009235
42Herpes simplex infection_Homo sapiens_hsa051681.00375231
43Vitamin B6 metabolism_Homo sapiens_hsa007501.00331248
44Protein export_Homo sapiens_hsa030600.98724142
45Viral carcinogenesis_Homo sapiens_hsa052030.96673327
46Alzheimers disease_Homo sapiens_hsa050100.96373148
47Primary immunodeficiency_Homo sapiens_hsa053400.94134958
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89223602
49Pentose phosphate pathway_Homo sapiens_hsa000300.87103423
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86076871
51Fatty acid metabolism_Homo sapiens_hsa012120.85669743
52Butanoate metabolism_Homo sapiens_hsa006500.85159119
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84406036
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80585239
55HTLV-I infection_Homo sapiens_hsa051660.78314240
56Peroxisome_Homo sapiens_hsa041460.78300406
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78061165
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78045477
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77254212
60Cardiac muscle contraction_Homo sapiens_hsa042600.75283366
61N-Glycan biosynthesis_Homo sapiens_hsa005100.73809204
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73359994
63Lysine degradation_Homo sapiens_hsa003100.71490390
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71113700
65Carbon metabolism_Homo sapiens_hsa012000.70922092
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70664547
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67117329
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65715230
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64979437
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61046947
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60733029
72Legionellosis_Homo sapiens_hsa051340.58482300
73Thyroid cancer_Homo sapiens_hsa052160.56818948
74Small cell lung cancer_Homo sapiens_hsa052220.55859275
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54901420
76Measles_Homo sapiens_hsa051620.53189173
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52371197
78Oocyte meiosis_Homo sapiens_hsa041140.50322219
79beta-Alanine metabolism_Homo sapiens_hsa004100.48472969
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47713675
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46961386
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45764212
83MicroRNAs in cancer_Homo sapiens_hsa052060.43649976
84Hematopoietic cell lineage_Homo sapiens_hsa046400.41806960
85Glutathione metabolism_Homo sapiens_hsa004800.41416552
86Sulfur metabolism_Homo sapiens_hsa009200.41331556
87Caffeine metabolism_Homo sapiens_hsa002320.41186599
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.39958098
89Apoptosis_Homo sapiens_hsa042100.38694083
90Shigellosis_Homo sapiens_hsa051310.38051939
91Fatty acid degradation_Homo sapiens_hsa000710.37383292
92Galactose metabolism_Homo sapiens_hsa000520.36949919
93Hepatitis B_Homo sapiens_hsa051610.36115977
94Acute myeloid leukemia_Homo sapiens_hsa052210.34267501
95Arginine and proline metabolism_Homo sapiens_hsa003300.34186376
96B cell receptor signaling pathway_Homo sapiens_hsa046620.32864784
97Notch signaling pathway_Homo sapiens_hsa043300.32338876
98Renin-angiotensin system_Homo sapiens_hsa046140.29684976
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.28964518
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28798762
101Chronic myeloid leukemia_Homo sapiens_hsa052200.28321610
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.28134165
103Alcoholism_Homo sapiens_hsa050340.27532607
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27268533
105Influenza A_Homo sapiens_hsa051640.26973850
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26900608
107Regulation of autophagy_Homo sapiens_hsa041400.26892911
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.25967980
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24626418
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22319868
111Basal cell carcinoma_Homo sapiens_hsa052170.20714848
112Metabolic pathways_Homo sapiens_hsa011000.20097471
113Leishmaniasis_Homo sapiens_hsa051400.18919021
114Viral myocarditis_Homo sapiens_hsa054160.17446423
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15673850
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14744377
117TGF-beta signaling pathway_Homo sapiens_hsa043500.13946635
118Fructose and mannose metabolism_Homo sapiens_hsa000510.13749623
119* Pathways in cancer_Homo sapiens_hsa052000.13742118
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.12611289
121Adherens junction_Homo sapiens_hsa045200.11333839
122Platelet activation_Homo sapiens_hsa046110.10630728
123Arginine biosynthesis_Homo sapiens_hsa002200.09690691
124Hedgehog signaling pathway_Homo sapiens_hsa043400.09393086
125Vibrio cholerae infection_Homo sapiens_hsa051100.08791097
126Bladder cancer_Homo sapiens_hsa052190.08549345
127Wnt signaling pathway_Homo sapiens_hsa043100.07588180
128Hippo signaling pathway_Homo sapiens_hsa043900.07515393
129Tryptophan metabolism_Homo sapiens_hsa003800.07515253
130Pyruvate metabolism_Homo sapiens_hsa006200.07484832
131Collecting duct acid secretion_Homo sapiens_hsa049660.06932906
132* Colorectal cancer_Homo sapiens_hsa052100.06820334
133Tight junction_Homo sapiens_hsa045300.05283436
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.00041241
135Phototransduction_Homo sapiens_hsa04744-0.0419830
136Tyrosine metabolism_Homo sapiens_hsa00350-0.0248438

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