Rank | Gene Set | Z-score |
---|---|---|
1 | cardiac myofibril assembly (GO:0055003) | 6.17511795 |
2 | muscle filament sliding (GO:0030049) | 5.69413764 |
3 | actin-myosin filament sliding (GO:0033275) | 5.69413764 |
4 | myofibril assembly (GO:0030239) | 5.68121623 |
5 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 5.65000049 |
6 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 5.49679533 |
7 | sarcomere organization (GO:0045214) | 5.49638714 |
8 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 5.23298617 |
9 | regulation of cell communication by electrical coupling (GO:0010649) | 5.10370546 |
10 | regulation of relaxation of muscle (GO:1901077) | 5.09346279 |
11 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 4.97211797 |
12 | regulation of sarcomere organization (GO:0060297) | 4.88719773 |
13 | response to inactivity (GO:0014854) | 4.87948000 |
14 | actin-mediated cell contraction (GO:0070252) | 4.87548315 |
15 | cardiac muscle hypertrophy (GO:0003300) | 4.84985907 |
16 | cardiac muscle contraction (GO:0060048) | 4.81258239 |
17 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 4.79760259 |
18 | regulation of skeletal muscle contraction (GO:0014819) | 4.75676959 |
19 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 4.65671495 |
20 | striated muscle hypertrophy (GO:0014897) | 4.63398046 |
21 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 4.56086791 |
22 | regulation of actin filament-based movement (GO:1903115) | 4.48794539 |
23 | striated muscle contraction (GO:0006941) | 4.32985480 |
24 | muscle hypertrophy (GO:0014896) | 4.25702525 |
25 | creatine metabolic process (GO:0006600) | 4.21440416 |
26 | muscle contraction (GO:0006936) | 4.17504629 |
27 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.04173712 |
28 | regulation of striated muscle contraction (GO:0006942) | 4.02099793 |
29 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 4.01989655 |
30 | detection of calcium ion (GO:0005513) | 4.01491438 |
31 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 3.97968555 |
32 | response to muscle activity (GO:0014850) | 3.94509632 |
33 | actomyosin structure organization (GO:0031032) | 3.94336948 |
34 | carnitine shuttle (GO:0006853) | 3.94165292 |
35 | cardiac muscle tissue morphogenesis (GO:0055008) | 3.86781707 |
36 | muscle system process (GO:0003012) | 3.84237416 |
37 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 3.83245399 |
38 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 3.83221493 |
39 | regulation of sequestering of triglyceride (GO:0010889) | 3.76340691 |
40 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.75079268 |
41 | cardiac muscle cell development (GO:0055013) | 3.74928324 |
42 | fatty acid transmembrane transport (GO:1902001) | 3.73199646 |
43 | NADH metabolic process (GO:0006734) | 3.70936050 |
44 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.70631249 |
45 | regulation of membrane repolarization (GO:0060306) | 3.70327339 |
46 | adult heart development (GO:0007512) | 3.68558269 |
47 | tricarboxylic acid cycle (GO:0006099) | 3.68197974 |
48 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.65923414 |
49 | striated muscle adaptation (GO:0014888) | 3.62668071 |
50 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.62612749 |
51 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.62186330 |
52 | cardiac muscle adaptation (GO:0014887) | 3.61616405 |
53 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.61616405 |
54 | muscle hypertrophy in response to stress (GO:0003299) | 3.61616405 |
55 | actin filament-based movement (GO:0030048) | 3.61178716 |
56 | regulation of coenzyme metabolic process (GO:0051196) | 3.57886111 |
57 | regulation of cofactor metabolic process (GO:0051193) | 3.57886111 |
58 | regulation of ATPase activity (GO:0043462) | 3.56466846 |
59 | regulation of ATP catabolic process (GO:1903289) | 3.56466846 |
60 | heart contraction (GO:0060047) | 3.55304105 |
61 | heart process (GO:0003015) | 3.55304105 |
62 | vocalization behavior (GO:0071625) | 3.51167693 |
63 | regulation of cardiac muscle contraction (GO:0055117) | 3.50756838 |
64 | response to caffeine (GO:0031000) | 3.50191615 |
65 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.49868524 |
66 | regulation of the force of heart contraction (GO:0002026) | 3.49281132 |
67 | cardiac cell development (GO:0055006) | 3.48232741 |
68 | muscle tissue morphogenesis (GO:0060415) | 3.47579937 |
69 | negative regulation of protein localization to cell surface (GO:2000009) | 3.47287087 |
70 | ventricular cardiac muscle cell action potential (GO:0086005) | 3.43823598 |
71 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 3.43062655 |
72 | neuronal action potential propagation (GO:0019227) | 3.42765351 |
73 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 3.41956888 |
74 | presynaptic membrane assembly (GO:0097105) | 3.40956427 |
75 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 3.40792992 |
76 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 3.40792992 |
77 | skeletal muscle contraction (GO:0003009) | 3.40340555 |
78 | plasma membrane repair (GO:0001778) | 3.40237540 |
79 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.34599967 |
80 | carnitine transmembrane transport (GO:1902603) | 3.32878461 |
81 | positive regulation of cardiac muscle cell differentiation (GO:2000727) | 3.31285387 |
82 | cardiac conduction (GO:0061337) | 3.30244073 |
83 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.30209457 |
84 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.30209457 |
85 | regulation of cardiac muscle cell contraction (GO:0086004) | 3.30198783 |
86 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.27298313 |
87 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.27274631 |
88 | cell communication by electrical coupling (GO:0010644) | 3.24617788 |
89 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.23905648 |
90 | cardiac muscle cell action potential (GO:0086001) | 3.21480913 |
91 | cell communication involved in cardiac conduction (GO:0086065) | 3.20737088 |
92 | carnitine transport (GO:0015879) | 3.20349207 |
93 | amino-acid betaine transport (GO:0015838) | 3.20349207 |
94 | muscle fiber development (GO:0048747) | 3.19207934 |
95 | cardiac chamber formation (GO:0003207) | 3.17589760 |
96 | response to epinephrine (GO:0071871) | 3.17479425 |
97 | relaxation of muscle (GO:0090075) | 3.17268950 |
98 | striated muscle cell development (GO:0055002) | 3.16551052 |
99 | positive regulation of sodium ion transport (GO:0010765) | 3.15208056 |
100 | regulation of muscle contraction (GO:0006937) | 3.12849790 |
101 | skeletal muscle adaptation (GO:0043501) | 3.12518246 |
102 | respiratory electron transport chain (GO:0022904) | 3.11558934 |
103 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 3.11173794 |
104 | protein localization to synapse (GO:0035418) | 3.09268781 |
105 | presynaptic membrane organization (GO:0097090) | 3.09096224 |
106 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.08879282 |
107 | ATP synthesis coupled proton transport (GO:0015986) | 3.08879282 |
108 | regulation of cardiac muscle cell differentiation (GO:2000725) | 3.08474876 |
109 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.08254915 |
110 | cardiac ventricle formation (GO:0003211) | 3.08102230 |
111 | regulation of muscle system process (GO:0090257) | 3.06296244 |
112 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.05676549 |
113 | electron transport chain (GO:0022900) | 3.02993523 |
114 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.02770106 |
115 | positive regulation of cation channel activity (GO:2001259) | 3.02253270 |
116 | cellular response to epinephrine stimulus (GO:0071872) | 3.02112534 |
117 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.01989984 |
118 | regulation of heart rate (GO:0002027) | 2.99325863 |
119 | adrenergic receptor signaling pathway (GO:0071875) | 2.98746587 |
120 | relaxation of cardiac muscle (GO:0055119) | 2.97018903 |
121 | positive regulation of heart rate (GO:0010460) | 2.96931044 |
122 | glutamate receptor signaling pathway (GO:0007215) | 2.96649169 |
123 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.95588828 |
124 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.94796621 |
125 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.93025036 |
126 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.91015540 |
127 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 2.90932215 |
128 | neuron cell-cell adhesion (GO:0007158) | 2.90545586 |
129 | regulation of cation channel activity (GO:2001257) | 2.89253371 |
130 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 2.88710657 |
131 | regulation of heart contraction (GO:0008016) | 2.87152082 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.52595080 |
2 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.18784809 |
3 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.69623690 |
4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.72555874 |
5 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.71733119 |
6 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.62369154 |
7 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.36972466 |
8 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.29898191 |
9 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.29896955 |
10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.29084485 |
11 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.29084485 |
12 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.26795820 |
13 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.25480401 |
14 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.20374747 |
15 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 2.18790387 |
16 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.16442229 |
17 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.11367291 |
18 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.03395311 |
19 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.01693709 |
20 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.97560654 |
21 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.92007728 |
22 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.86510351 |
23 | VDR_22108803_ChIP-Seq_LS180_Human | 1.85260599 |
24 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.83022951 |
25 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.83018801 |
26 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.82394176 |
27 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.81334601 |
28 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.79839138 |
29 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.79707681 |
30 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.79543286 |
31 | P300_19829295_ChIP-Seq_ESCs_Human | 1.75916435 |
32 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.75038338 |
33 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.73576940 |
34 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.73122302 |
35 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.72207254 |
36 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.71988090 |
37 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.71335490 |
38 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.69613773 |
39 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.68036811 |
40 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.66109563 |
41 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.65506544 |
42 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.65506544 |
43 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.65445250 |
44 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.63825758 |
45 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.58907999 |
46 | FUS_26573619_Chip-Seq_HEK293_Human | 1.54561218 |
47 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.51094968 |
48 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.49134131 |
49 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.48251558 |
50 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.46502435 |
51 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.45458329 |
52 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.43527601 |
53 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.42608503 |
54 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.42296587 |
55 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.41047068 |
56 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.40124640 |
57 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.39522461 |
58 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.38779997 |
59 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.38623860 |
60 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.37461014 |
61 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.37208581 |
62 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.35988830 |
63 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.35600707 |
64 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.35315544 |
65 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.35089882 |
66 | AR_25329375_ChIP-Seq_VCAP_Human | 1.33958134 |
67 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.31778688 |
68 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.31369865 |
69 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.31361000 |
70 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.30784664 |
71 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.30317794 |
72 | TCF4_23295773_ChIP-Seq_U87_Human | 1.29038369 |
73 | STAT3_23295773_ChIP-Seq_U87_Human | 1.28493139 |
74 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.25438872 |
75 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.25133933 |
76 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.24942818 |
77 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.22991243 |
78 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.22192375 |
79 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.21491140 |
80 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.21312448 |
81 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.19920653 |
82 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.19827103 |
83 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.19001082 |
84 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.18231406 |
85 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.18086969 |
86 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.17744197 |
87 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.16026521 |
88 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.14530097 |
89 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.13958411 |
90 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.13826370 |
91 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.12858571 |
92 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.12430928 |
93 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.12322242 |
94 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.12312058 |
95 | GATA1_22025678_ChIP-Seq_K562_Human | 1.11922140 |
96 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.11747262 |
97 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.10957549 |
98 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.10233272 |
99 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.09159090 |
100 | TP53_16413492_ChIP-PET_HCT116_Human | 1.09150053 |
101 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.08649304 |
102 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.08254646 |
103 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.07791217 |
104 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.07791217 |
105 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.06619001 |
106 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.06141940 |
107 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.06050745 |
108 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.05992482 |
109 | TBL1_22424771_ChIP-Seq_293T_Human | 1.05882223 |
110 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.05315415 |
111 | AR_19668381_ChIP-Seq_PC3_Human | 1.05166426 |
112 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.03658736 |
113 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.02647528 |
114 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.02228875 |
115 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.01952823 |
116 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.01919021 |
117 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.00461791 |
118 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.00052895 |
119 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.99603752 |
120 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.99506747 |
121 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.99490866 |
122 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.99480324 |
123 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 0.98988935 |
124 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.98917651 |
125 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.98381071 |
126 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.98358711 |
127 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.98178032 |
128 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.97541133 |
129 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.97541133 |
130 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.97154313 |
131 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.96492603 |
132 | NFYB_21822215_ChIP-Seq_K562_Human | 0.95324553 |
133 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.93960083 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002837_dystrophic_cardiac_calcinosis | 4.92174437 |
2 | MP0003646_muscle_fatigue | 4.50802209 |
3 | MP0000751_myopathy | 4.43796077 |
4 | MP0000749_muscle_degeneration | 3.88132477 |
5 | MP0004084_abnormal_cardiac_muscle | 3.87475223 |
6 | MP0004215_abnormal_myocardial_fiber | 3.72279965 |
7 | MP0004036_abnormal_muscle_relaxation | 3.39933132 |
8 | MP0004145_abnormal_muscle_electrophysio | 3.39388317 |
9 | MP0004859_abnormal_synaptic_plasticity | 3.01353017 |
10 | MP0003880_abnormal_central_pattern | 2.95984005 |
11 | MP0005330_cardiomyopathy | 2.63730674 |
12 | MP0002972_abnormal_cardiac_muscle | 2.51763193 |
13 | MP0004484_altered_response_of | 2.46546773 |
14 | MP0005620_abnormal_muscle_contractility | 2.44722422 |
15 | MP0002106_abnormal_muscle_physiology | 2.21729748 |
16 | MP0004087_abnormal_muscle_fiber | 2.18642139 |
17 | MP0003137_abnormal_impulse_conducting | 2.14595159 |
18 | MP0004510_myositis | 2.11479824 |
19 | MP0003635_abnormal_synaptic_transmissio | 2.09109634 |
20 | MP0005670_abnormal_white_adipose | 2.05839766 |
21 | MP0001968_abnormal_touch/_nociception | 2.03496888 |
22 | MP0004085_abnormal_heartbeat | 2.03039965 |
23 | MP0008775_abnormal_heart_ventricle | 2.00391498 |
24 | MP0009745_abnormal_behavioral_response | 1.98215023 |
25 | MP0005369_muscle_phenotype | 1.88767088 |
26 | MP0009046_muscle_twitch | 1.84930223 |
27 | MP0004270_analgesia | 1.79590355 |
28 | MP0006138_congestive_heart_failure | 1.72792687 |
29 | MP0000750_abnormal_muscle_regeneration | 1.72784700 |
30 | MP0004130_abnormal_muscle_cell | 1.71341052 |
31 | MP0002063_abnormal_learning/memory/cond | 1.70820958 |
32 | MP0001544_abnormal_cardiovascular_syste | 1.68209539 |
33 | MP0005385_cardiovascular_system_phenoty | 1.68209539 |
34 | MP0002064_seizures | 1.66569834 |
35 | MP0000759_abnormal_skeletal_muscle | 1.66365514 |
36 | MP0002127_abnormal_cardiovascular_syste | 1.64594496 |
37 | MP0000747_muscle_weakness | 1.63298357 |
38 | MP0000372_irregular_coat_pigmentation | 1.62801231 |
39 | MP0000013_abnormal_adipose_tissue | 1.62092187 |
40 | MP0002736_abnormal_nociception_after | 1.59600608 |
41 | MP0002269_muscular_atrophy | 1.59596763 |
42 | MP0002572_abnormal_emotion/affect_behav | 1.58140129 |
43 | MP0002272_abnormal_nervous_system | 1.57052962 |
44 | MP0002735_abnormal_chemical_nociception | 1.52479498 |
45 | MP0003828_pulmonary_edema | 1.47838813 |
46 | MP0001486_abnormal_startle_reflex | 1.47581818 |
47 | MP0010630_abnormal_cardiac_muscle | 1.47533225 |
48 | MP0004233_abnormal_muscle_weight | 1.46432673 |
49 | MP0001188_hyperpigmentation | 1.39919499 |
50 | MP0005646_abnormal_pituitary_gland | 1.39007773 |
51 | MP0002067_abnormal_sensory_capabilities | 1.38151695 |
52 | MP0003950_abnormal_plasma_membrane | 1.34955678 |
53 | MP0009780_abnormal_chondrocyte_physiolo | 1.33159454 |
54 | MP0003879_abnormal_hair_cell | 1.31726642 |
55 | MP0002734_abnormal_mechanical_nocicepti | 1.30249368 |
56 | MP0002332_abnormal_exercise_endurance | 1.25050328 |
57 | MP0005171_absent_coat_pigmentation | 1.23974054 |
58 | MP0001440_abnormal_grooming_behavior | 1.18541077 |
59 | MP0005266_abnormal_metabolism | 1.15718576 |
60 | MP0005386_behavior/neurological_phenoty | 1.14080303 |
61 | MP0004924_abnormal_behavior | 1.14080303 |
62 | MP0001661_extended_life_span | 1.10093405 |
63 | MP0006036_abnormal_mitochondrial_physio | 1.06348103 |
64 | MP0002139_abnormal_hepatobiliary_system | 1.05810168 |
65 | MP0008569_lethality_at_weaning | 1.02034190 |
66 | MP0003787_abnormal_imprinting | 1.01388404 |
67 | MP0003221_abnormal_cardiomyocyte_apopto | 1.00974513 |
68 | MP0002822_catalepsy | 0.94433152 |
69 | MP0005187_abnormal_penis_morphology | 0.94394990 |
70 | MP0002108_abnormal_muscle_morphology | 0.93645958 |
71 | MP0003136_yellow_coat_color | 0.93515810 |
72 | MP0001984_abnormal_olfaction | 0.93507372 |
73 | MP0004147_increased_porphyrin_level | 0.91928190 |
74 | MP0001501_abnormal_sleep_pattern | 0.91911046 |
75 | MP0006276_abnormal_autonomic_nervous | 0.89322508 |
76 | MP0001970_abnormal_pain_threshold | 0.87596428 |
77 | MP0003122_maternal_imprinting | 0.87012611 |
78 | MP0002557_abnormal_social/conspecific_i | 0.85028786 |
79 | MP0002184_abnormal_innervation | 0.83700624 |
80 | MP0000003_abnormal_adipose_tissue | 0.83685421 |
81 | MP0002971_abnormal_brown_adipose | 0.83175468 |
82 | MP0005451_abnormal_body_composition | 0.79882758 |
83 | MP0001529_abnormal_vocalization | 0.79453791 |
84 | MP0004142_abnormal_muscle_tone | 0.78039652 |
85 | MP0000733_abnormal_muscle_development | 0.77741554 |
86 | MP0005332_abnormal_amino_acid | 0.76793919 |
87 | MP0005645_abnormal_hypothalamus_physiol | 0.75898344 |
88 | MP0006035_abnormal_mitochondrial_morpho | 0.75118620 |
89 | MP0002066_abnormal_motor_capabilities/c | 0.74511749 |
90 | MP0002102_abnormal_ear_morphology | 0.73383241 |
91 | MP0004043_abnormal_pH_regulation | 0.72425736 |
92 | MP0001485_abnormal_pinna_reflex | 0.71930876 |
93 | MP0002234_abnormal_pharynx_morphology | 0.70594757 |
94 | MP0000778_abnormal_nervous_system | 0.70375296 |
95 | MP0000230_abnormal_systemic_arterial | 0.69259673 |
96 | MP0003806_abnormal_nucleotide_metabolis | 0.69042432 |
97 | MP0002078_abnormal_glucose_homeostasis | 0.68084416 |
98 | MP0001502_abnormal_circadian_rhythm | 0.67439999 |
99 | MP0002733_abnormal_thermal_nociception | 0.67330474 |
100 | MP0003633_abnormal_nervous_system | 0.67141175 |
101 | MP0001905_abnormal_dopamine_level | 0.66708049 |
102 | MP0003045_fibrosis | 0.66631509 |
103 | MP0002876_abnormal_thyroid_physiology | 0.66545725 |
104 | MP0005423_abnormal_somatic_nervous | 0.65353811 |
105 | MP0008004_abnormal_stomach_pH | 0.64699480 |
106 | MP0005165_increased_susceptibility_to | 0.64309383 |
107 | MP0002909_abnormal_adrenal_gland | 0.63090419 |
108 | MP0005375_adipose_tissue_phenotype | 0.61137329 |
109 | MP0005409_darkened_coat_color | 0.60129088 |
110 | MP0006292_abnormal_olfactory_placode | 0.59248864 |
111 | MP0000266_abnormal_heart_morphology | 0.59214022 |
112 | MP0002882_abnormal_neuron_morphology | 0.58209138 |
113 | MP0001963_abnormal_hearing_physiology | 0.56303399 |
114 | MP0002638_abnormal_pupillary_reflex | 0.55897733 |
115 | MP0005535_abnormal_body_temperature | 0.55664976 |
116 | MP0004811_abnormal_neuron_physiology | 0.55318591 |
117 | MP0003195_calcinosis | 0.53458469 |
118 | MP0000343_altered_response_to | 0.51828856 |
119 | MP0005551_abnormal_eye_electrophysiolog | 0.49756961 |
120 | MP0002138_abnormal_hepatobiliary_system | 0.48826559 |
121 | MP0005253_abnormal_eye_physiology | 0.48338347 |
122 | MP0001986_abnormal_taste_sensitivity | 0.48098673 |
123 | MP0005167_abnormal_blood-brain_barrier | 0.46897511 |
124 | MP0002128_abnormal_blood_circulation | 0.46396386 |
125 | MP0010329_abnormal_lipoprotein_level | 0.44858840 |
126 | MP0005666_abnormal_adipose_tissue | 0.43840010 |
127 | MP0005085_abnormal_gallbladder_physiolo | 0.43054456 |
128 | MP0002118_abnormal_lipid_homeostasis | 0.41328059 |
129 | MP0010368_abnormal_lymphatic_system | 0.37771158 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Sudden death (HP:0001699) | 6.69334995 |
2 | Calf muscle hypertrophy (HP:0008981) | 6.32759625 |
3 | Muscle hypertrophy of the lower extremities (HP:0008968) | 6.18558699 |
4 | Exercise-induced myalgia (HP:0003738) | 5.95526951 |
5 | Exercise-induced muscle cramps (HP:0003710) | 5.42199323 |
6 | Atrial fibrillation (HP:0005110) | 5.33096374 |
7 | Abnormality of the calf musculature (HP:0001430) | 5.13837108 |
8 | Primary atrial arrhythmia (HP:0001692) | 5.00417443 |
9 | Focal motor seizures (HP:0011153) | 4.99782165 |
10 | Ventricular tachycardia (HP:0004756) | 4.86984058 |
11 | Supraventricular tachycardia (HP:0004755) | 4.79038170 |
12 | Supraventricular arrhythmia (HP:0005115) | 4.64996593 |
13 | Syncope (HP:0001279) | 4.38224793 |
14 | Subaortic stenosis (HP:0001682) | 4.04867696 |
15 | Abnormality of the left ventricular outflow tract (HP:0011103) | 4.04867696 |
16 | Muscle fiber splitting (HP:0003555) | 4.03940191 |
17 | Lipoatrophy (HP:0100578) | 3.96143686 |
18 | Hyporeflexia of lower limbs (HP:0002600) | 3.82360518 |
19 | EMG: myopathic abnormalities (HP:0003458) | 3.80182252 |
20 | Prolonged QT interval (HP:0001657) | 3.68252131 |
21 | Hyperventilation (HP:0002883) | 3.61438578 |
22 | EMG: neuropathic changes (HP:0003445) | 3.51708725 |
23 | Acute necrotizing encephalopathy (HP:0006965) | 3.50876938 |
24 | Myoglobinuria (HP:0002913) | 3.48645039 |
25 | Bundle branch block (HP:0011710) | 3.48454715 |
26 | Muscle fiber inclusion bodies (HP:0100299) | 3.45596513 |
27 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 3.37731559 |
28 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.34842341 |
29 | Epileptic encephalopathy (HP:0200134) | 3.32749089 |
30 | Ventricular arrhythmia (HP:0004308) | 3.18821426 |
31 | Dilated cardiomyopathy (HP:0001644) | 3.16136070 |
32 | Right ventricular cardiomyopathy (HP:0011663) | 3.15866288 |
33 | Febrile seizures (HP:0002373) | 3.15500346 |
34 | Myopathic facies (HP:0002058) | 3.14315834 |
35 | Myotonia (HP:0002486) | 3.06397776 |
36 | Type 1 muscle fiber predominance (HP:0003803) | 3.04445810 |
37 | Atonic seizures (HP:0010819) | 3.00240331 |
38 | Abnormal EKG (HP:0003115) | 2.99960647 |
39 | Palpitations (HP:0001962) | 2.98958641 |
40 | Progressive macrocephaly (HP:0004481) | 2.98756278 |
41 | Nemaline bodies (HP:0003798) | 2.98363666 |
42 | Round ear (HP:0100830) | 2.98016793 |
43 | Left ventricular hypertrophy (HP:0001712) | 2.97127251 |
44 | Frequent falls (HP:0002359) | 2.92445449 |
45 | Heart block (HP:0012722) | 2.86529815 |
46 | Broad-based gait (HP:0002136) | 2.71099513 |
47 | Focal seizures (HP:0007359) | 2.68182426 |
48 | Acute encephalopathy (HP:0006846) | 2.65071184 |
49 | Mitochondrial inheritance (HP:0001427) | 2.64155607 |
50 | Abnormal atrioventricular conduction (HP:0005150) | 2.62641935 |
51 | Asymmetric septal hypertrophy (HP:0001670) | 2.62087846 |
52 | Distal lower limb muscle weakness (HP:0009053) | 2.61147714 |
53 | Ulnar deviation of the wrist (HP:0003049) | 2.50391216 |
54 | Neck muscle weakness (HP:0000467) | 2.45082351 |
55 | Increased CSF lactate (HP:0002490) | 2.44240170 |
56 | Rhabdomyolysis (HP:0003201) | 2.43302563 |
57 | Muscle stiffness (HP:0003552) | 2.39273198 |
58 | Increased connective tissue (HP:0009025) | 2.38393012 |
59 | Difficulty running (HP:0009046) | 2.37667971 |
60 | Ragged-red muscle fibers (HP:0003200) | 2.37583777 |
61 | Ventricular fibrillation (HP:0001663) | 2.36086412 |
62 | Areflexia of lower limbs (HP:0002522) | 2.34784575 |
63 | Exercise intolerance (HP:0003546) | 2.32545293 |
64 | Atrioventricular block (HP:0001678) | 2.32213450 |
65 | Pheochromocytoma (HP:0002666) | 2.30801963 |
66 | Steppage gait (HP:0003376) | 2.30015412 |
67 | Dysmetric saccades (HP:0000641) | 2.29813956 |
68 | Hepatocellular necrosis (HP:0001404) | 2.26203473 |
69 | Rimmed vacuoles (HP:0003805) | 2.25974554 |
70 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.23472655 |
71 | Abnormality of alanine metabolism (HP:0010916) | 2.23472655 |
72 | Hyperalaninemia (HP:0003348) | 2.23472655 |
73 | Absent phalangeal crease (HP:0006109) | 2.17735744 |
74 | Hepatic necrosis (HP:0002605) | 2.16479122 |
75 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.12919124 |
76 | Poor eye contact (HP:0000817) | 2.12781188 |
77 | Absence seizures (HP:0002121) | 2.11578583 |
78 | Increased variability in muscle fiber diameter (HP:0003557) | 2.11161212 |
79 | Generalized tonic-clonic seizures (HP:0002069) | 2.09373676 |
80 | Congenital malformation of the right heart (HP:0011723) | 2.08550584 |
81 | Double outlet right ventricle (HP:0001719) | 2.08550584 |
82 | Dialeptic seizures (HP:0011146) | 2.08432177 |
83 | Neuroendocrine neoplasm (HP:0100634) | 2.08407398 |
84 | Abnormality of glycolysis (HP:0004366) | 2.07256413 |
85 | Increased serum pyruvate (HP:0003542) | 2.07256413 |
86 | Muscular dystrophy (HP:0003560) | 2.01636590 |
87 | Gaze-evoked nystagmus (HP:0000640) | 2.00509255 |
88 | Distal lower limb amyotrophy (HP:0008944) | 2.00426625 |
89 | Optic disc pallor (HP:0000543) | 2.00247073 |
90 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.00090364 |
91 | Gowers sign (HP:0003391) | 1.99848050 |
92 | Scapular winging (HP:0003691) | 1.99514538 |
93 | Bradycardia (HP:0001662) | 1.97096131 |
94 | Palmoplantar keratoderma (HP:0000982) | 1.95658832 |
95 | Abnormality of the foot musculature (HP:0001436) | 1.91244556 |
96 | Hyperkalemia (HP:0002153) | 1.88953703 |
97 | Lactic acidosis (HP:0003128) | 1.88900400 |
98 | Calcaneovalgus deformity (HP:0001848) | 1.87963152 |
99 | Respiratory failure (HP:0002878) | 1.87709447 |
100 | Foot dorsiflexor weakness (HP:0009027) | 1.87370366 |
101 | Proximal amyotrophy (HP:0007126) | 1.87340149 |
102 | Cerebral edema (HP:0002181) | 1.86473311 |
103 | Limb-girdle muscle atrophy (HP:0003797) | 1.84889290 |
104 | Lower limb amyotrophy (HP:0007210) | 1.83336727 |
105 | Hypoplastic left heart (HP:0004383) | 1.83296603 |
106 | Insidious onset (HP:0003587) | 1.81242304 |
107 | Termporal pattern (HP:0011008) | 1.81242304 |
108 | Abnormal finger flexion creases (HP:0006143) | 1.80247696 |
109 | Distal arthrogryposis (HP:0005684) | 1.79987530 |
110 | Bulbar palsy (HP:0001283) | 1.79759682 |
111 | Fetal akinesia sequence (HP:0001989) | 1.79161381 |
112 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 1.79137810 |
113 | Nonprogressive disorder (HP:0003680) | 1.77962372 |
114 | Weak cry (HP:0001612) | 1.77239078 |
115 | Visual hallucinations (HP:0002367) | 1.76816974 |
116 | Generalized muscle weakness (HP:0003324) | 1.76434146 |
117 | Inability to walk (HP:0002540) | 1.75401094 |
118 | Malignant hyperthermia (HP:0002047) | 1.72168510 |
119 | Difficulty climbing stairs (HP:0003551) | 1.71028400 |
120 | Hip contracture (HP:0003273) | 1.69817863 |
121 | Deformed tarsal bones (HP:0008119) | 1.68204104 |
122 | Progressive muscle weakness (HP:0003323) | 1.66569324 |
123 | Abnormality of the shoulder girdle musculature (HP:0001435) | 1.65086429 |
124 | Sudden cardiac death (HP:0001645) | 1.64550361 |
125 | Ketoacidosis (HP:0001993) | 1.62465691 |
126 | Late onset (HP:0003584) | 1.59087854 |
127 | Blue irides (HP:0000635) | 1.58042705 |
128 | Abnormality of the neuromuscular junction (HP:0003398) | 1.56965468 |
129 | Fatigable weakness (HP:0003473) | 1.56965468 |
130 | Congestive heart failure (HP:0001635) | 1.56722350 |
131 | Increased intramyocellular lipid droplets (HP:0012240) | 1.56526687 |
132 | Oligomenorrhea (HP:0000876) | 1.56263828 |
Rank | Gene Set | Z-score |
---|---|---|
1 | OBSCN | 5.31639508 |
2 | CASK | 5.06409071 |
3 | EPHA4 | 2.92677104 |
4 | FRK | 2.83220635 |
5 | MYLK | 2.79289296 |
6 | NTRK3 | 2.75568688 |
7 | PHKG2 | 2.49505895 |
8 | PHKG1 | 2.49505895 |
9 | TTN | 2.46987208 |
10 | MUSK | 2.29730656 |
11 | MAP2K7 | 2.26511950 |
12 | PIK3CA | 2.05979338 |
13 | PRPF4B | 2.03350909 |
14 | PDK4 | 1.93148191 |
15 | PDK3 | 1.93148191 |
16 | STK24 | 1.90536780 |
17 | MAP3K4 | 1.88530104 |
18 | DMPK | 1.84712201 |
19 | DAPK2 | 1.84398673 |
20 | PLK2 | 1.79262412 |
21 | AKT3 | 1.77281890 |
22 | CCNB1 | 1.75794468 |
23 | ZAK | 1.70325114 |
24 | MAP3K12 | 1.64953953 |
25 | TNIK | 1.60238333 |
26 | PINK1 | 1.54709755 |
27 | INSRR | 1.52049752 |
28 | SIK3 | 1.46056779 |
29 | MAP2K4 | 1.38036812 |
30 | GRK7 | 1.31497050 |
31 | CDK19 | 1.28627524 |
32 | CAMK2A | 1.27221000 |
33 | NME1 | 1.26990878 |
34 | RIPK4 | 1.26955987 |
35 | MAPKAPK3 | 1.25229580 |
36 | DAPK1 | 1.23765147 |
37 | WNK3 | 1.22283440 |
38 | PDK2 | 1.19925852 |
39 | TIE1 | 1.17158967 |
40 | MAPK12 | 1.14604619 |
41 | CAMK2D | 1.12087724 |
42 | MAPK13 | 1.10323524 |
43 | LMTK2 | 1.09995839 |
44 | LIMK1 | 1.09978494 |
45 | PTK2B | 1.07938704 |
46 | SGK2 | 1.06993142 |
47 | BMPR2 | 1.05016761 |
48 | STK38L | 1.03592178 |
49 | CAMK1 | 0.98296110 |
50 | PKN1 | 0.88081009 |
51 | PRKCE | 0.86361487 |
52 | DAPK3 | 0.85141365 |
53 | MAP3K7 | 0.81395569 |
54 | CDC42BPA | 0.81349342 |
55 | MAP2K6 | 0.79906148 |
56 | ERBB3 | 0.79102383 |
57 | CAMK2B | 0.77131235 |
58 | SGK494 | 0.76040419 |
59 | SGK223 | 0.76040419 |
60 | OXSR1 | 0.76013138 |
61 | PAK6 | 0.75000922 |
62 | GRK5 | 0.74666071 |
63 | PAK3 | 0.73026484 |
64 | MKNK2 | 0.72828003 |
65 | NEK9 | 0.71862026 |
66 | SGK1 | 0.71057044 |
67 | PNCK | 0.70683366 |
68 | CAMK4 | 0.70245152 |
69 | STK38 | 0.69769988 |
70 | ACVR1B | 0.68142480 |
71 | PRKCG | 0.67644363 |
72 | MINK1 | 0.66952434 |
73 | NEK1 | 0.66518182 |
74 | AKT2 | 0.63256201 |
75 | BCKDK | 0.62482715 |
76 | MAP2K1 | 0.62421835 |
77 | ADRBK2 | 0.61284267 |
78 | CAMK2G | 0.61238098 |
79 | MAPK7 | 0.60847764 |
80 | SGK3 | 0.59980219 |
81 | EPHA3 | 0.59118129 |
82 | MARK1 | 0.57756166 |
83 | CAMKK2 | 0.55986298 |
84 | CDK5 | 0.55776908 |
85 | KSR1 | 0.54535652 |
86 | ROCK1 | 0.53651560 |
87 | MAP2K3 | 0.53411704 |
88 | SIK2 | 0.52730737 |
89 | MAP4K2 | 0.52177324 |
90 | PRKACA | 0.51697060 |
91 | PRKG1 | 0.50357332 |
92 | UHMK1 | 0.47723065 |
93 | GRK1 | 0.46849232 |
94 | PRKACG | 0.46667974 |
95 | LATS1 | 0.46123264 |
96 | FER | 0.46055456 |
97 | MAP3K5 | 0.45665336 |
98 | BRAF | 0.44805774 |
99 | PRKACB | 0.41989761 |
100 | TRPM7 | 0.40856357 |
101 | STK39 | 0.40826650 |
102 | FGFR2 | 0.40744183 |
103 | ARAF | 0.40365817 |
104 | STK4 | 0.40018444 |
105 | MAPK4 | 0.40003340 |
106 | PRKAA2 | 0.37950477 |
107 | ADRBK1 | 0.37712426 |
108 | MAP3K6 | 0.37492977 |
109 | PIK3CG | 0.37413169 |
110 | PRKD1 | 0.37283125 |
111 | WNK4 | 0.36606207 |
112 | PRKAA1 | 0.35720349 |
113 | ROCK2 | 0.35560125 |
114 | ILK | 0.34970829 |
115 | NTRK2 | 0.33817703 |
116 | BMPR1B | 0.33592982 |
117 | TGFBR2 | 0.33514684 |
118 | CDK3 | 0.33394360 |
119 | MARK3 | 0.29772479 |
120 | STK11 | 0.29160321 |
121 | PDK1 | 0.27747510 |
122 | PRKCQ | 0.27646230 |
123 | WNK1 | 0.27368921 |
124 | BCR | 0.27239030 |
125 | MAP3K13 | 0.26834695 |
126 | RPS6KA3 | 0.26707755 |
127 | MAPK10 | 0.25829095 |
128 | NEK6 | 0.25825425 |
129 | RPS6KA6 | 0.25459844 |
130 | PRKCA | 0.24690970 |
131 | RPS6KA1 | 0.21859049 |
132 | PRKCH | 0.21494950 |
133 | FGFR3 | 0.20741906 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 3.88723110 |
2 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 3.31216067 |
3 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 3.18737900 |
4 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.07068316 |
5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.00157299 |
6 | Nicotine addiction_Homo sapiens_hsa05033 | 2.97352050 |
7 | Parkinsons disease_Homo sapiens_hsa05012 | 2.58824591 |
8 | Alzheimers disease_Homo sapiens_hsa05010 | 2.36289491 |
9 | Circadian entrainment_Homo sapiens_hsa04713 | 2.26567153 |
10 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.19005908 |
11 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.17791408 |
12 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 2.14904203 |
13 | Calcium signaling pathway_Homo sapiens_hsa04020 | 2.07834342 |
14 | Olfactory transduction_Homo sapiens_hsa04740 | 2.07781106 |
15 | Morphine addiction_Homo sapiens_hsa05032 | 1.98483474 |
16 | Long-term potentiation_Homo sapiens_hsa04720 | 1.92027523 |
17 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.86474729 |
18 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.85800149 |
19 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.82189738 |
20 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.79104724 |
21 | Huntingtons disease_Homo sapiens_hsa05016 | 1.75448269 |
22 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.73958800 |
23 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.73924828 |
24 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.73170852 |
25 | Insulin secretion_Homo sapiens_hsa04911 | 1.66332334 |
26 | GABAergic synapse_Homo sapiens_hsa04727 | 1.65193528 |
27 | Taste transduction_Homo sapiens_hsa04742 | 1.63986004 |
28 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.61054713 |
29 | Salivary secretion_Homo sapiens_hsa04970 | 1.58124936 |
30 | Renin secretion_Homo sapiens_hsa04924 | 1.53959554 |
31 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.53160248 |
32 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.52640748 |
33 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.51393436 |
34 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.47278016 |
35 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.46432597 |
36 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.43426996 |
37 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.38020235 |
38 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.36279919 |
39 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.36150046 |
40 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.34362358 |
41 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.30264330 |
42 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.25777092 |
43 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.25622179 |
44 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.23349505 |
45 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.21746085 |
46 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.21649191 |
47 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.19894881 |
48 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.17957396 |
49 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.14935674 |
50 | Long-term depression_Homo sapiens_hsa04730 | 1.12765198 |
51 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.11453981 |
52 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.08358710 |
53 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.07791719 |
54 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.05808871 |
55 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.02186208 |
56 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.97290852 |
57 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.95225260 |
58 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.95024027 |
59 | Peroxisome_Homo sapiens_hsa04146 | 0.94124729 |
60 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.92433108 |
61 | Phototransduction_Homo sapiens_hsa04744 | 0.91790749 |
62 | Circadian rhythm_Homo sapiens_hsa04710 | 0.87209992 |
63 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.84729942 |
64 | Bile secretion_Homo sapiens_hsa04976 | 0.84119393 |
65 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.83936226 |
66 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.83452164 |
67 | Histidine metabolism_Homo sapiens_hsa00340 | 0.83022172 |
68 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.82380636 |
69 | Carbon metabolism_Homo sapiens_hsa01200 | 0.82372044 |
70 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.72529422 |
71 | Axon guidance_Homo sapiens_hsa04360 | 0.72223551 |
72 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.71203127 |
73 | Gap junction_Homo sapiens_hsa04540 | 0.71061700 |
74 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.69274893 |
75 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.67451055 |
76 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.67109369 |
77 | ABC transporters_Homo sapiens_hsa02010 | 0.67054630 |
78 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.64239044 |
79 | Cocaine addiction_Homo sapiens_hsa05030 | 0.64099026 |
80 | Melanogenesis_Homo sapiens_hsa04916 | 0.63582370 |
81 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.63469851 |
82 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.61696689 |
83 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.60284510 |
84 | Viral myocarditis_Homo sapiens_hsa05416 | 0.57335638 |
85 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.57054144 |
86 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.55880457 |
87 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.55087438 |
88 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.54690382 |
89 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.53000211 |
90 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.52512719 |
91 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.52489155 |
92 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.51965768 |
93 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.48319840 |
94 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.48305414 |
95 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.47994387 |
96 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.46853319 |
97 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.46683328 |
98 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.45827328 |
99 | Sulfur relay system_Homo sapiens_hsa04122 | 0.45553349 |
100 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.44772786 |
101 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.44364838 |
102 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.44141561 |
103 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.43838679 |
104 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.42702727 |
105 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.42055187 |
106 | Retinol metabolism_Homo sapiens_hsa00830 | 0.41928345 |
107 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.41413165 |
108 | Focal adhesion_Homo sapiens_hsa04510 | 0.40791727 |
109 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.40774280 |
110 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.39849822 |
111 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.39732527 |
112 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.39540783 |
113 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.39140922 |
114 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.39090199 |
115 | Melanoma_Homo sapiens_hsa05218 | 0.38661586 |
116 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.38031295 |
117 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.37861138 |
118 | Tight junction_Homo sapiens_hsa04530 | 0.37550304 |
119 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.37201759 |
120 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.36564770 |
121 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.35699020 |
122 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.35004028 |
123 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.34735145 |
124 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.34700420 |
125 | Glioma_Homo sapiens_hsa05214 | 0.34542246 |
126 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.33692726 |
127 | Insulin resistance_Homo sapiens_hsa04931 | 0.31799528 |
128 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.31670640 |
129 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.31551042 |
130 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.28356734 |
131 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.27942886 |
132 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.26875383 |
133 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.26715972 |
134 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.25991511 |
135 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.24021567 |
136 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.23980154 |
137 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.22317550 |
138 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.21203545 |
139 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.19809369 |