MLKL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.60727543
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.60727543
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.46996713
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.46996713
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.05935556
6antigen processing and presentation of endogenous antigen (GO:0019883)4.81312854
7negative regulation of interleukin-12 production (GO:0032695)4.66296103
8positive regulation of interferon-alpha production (GO:0032727)4.54311838
9neutrophil activation involved in immune response (GO:0002283)4.51243269
10response to interferon-alpha (GO:0035455)4.41305858
11detection of other organism (GO:0098543)4.38395244
12response to interferon-beta (GO:0035456)4.27882813
13regulation of interferon-alpha production (GO:0032647)4.27366824
14regulation of gamma-delta T cell activation (GO:0046643)4.11601724
15leukocyte aggregation (GO:0070486)4.11523049
16detection of bacterium (GO:0016045)4.10823063
17cellular response to type I interferon (GO:0071357)4.02553663
18type I interferon signaling pathway (GO:0060337)4.02553663
19response to type I interferon (GO:0034340)4.02348317
20cellular extravasation (GO:0045123)3.97218535
21cellular response to interferon-beta (GO:0035458)3.93868857
22response to interleukin-15 (GO:0070672)3.89036096
23negative regulation of lymphocyte mediated immunity (GO:0002707)3.88467135
24detection of external biotic stimulus (GO:0098581)3.85146943
25positive regulation by symbiont of host defense response (GO:0052509)3.81679591
26modulation by symbiont of host defense response (GO:0052031)3.81679591
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.81679591
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.81679591
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.81679591
30modulation by symbiont of host immune response (GO:0052553)3.81679591
31microglial cell activation (GO:0001774)3.81629769
32negative regulation of viral genome replication (GO:0045071)3.71853934
33negative regulation of T cell mediated immunity (GO:0002710)3.70526065
34positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.70212570
35immunoglobulin mediated immune response (GO:0016064)3.66891420
36response to peptidoglycan (GO:0032494)3.66828276
37regulation of T-helper 1 cell differentiation (GO:0045625)3.60047203
38regulation of gamma-delta T cell differentiation (GO:0045586)3.59514953
39cellular response to interleukin-15 (GO:0071350)3.55202761
40Arp2/3 complex-mediated actin nucleation (GO:0034314)3.52572755
41macrophage activation (GO:0042116)3.50946998
42regulation of RIG-I signaling pathway (GO:0039535)3.49862456
43detection of biotic stimulus (GO:0009595)3.45193742
44respiratory burst (GO:0045730)3.44436414
45negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.43302304
46negative regulation of leukocyte mediated immunity (GO:0002704)3.43071257
47regulation of interferon-beta biosynthetic process (GO:0045357)3.41581689
48positive regulation of natural killer cell differentiation (GO:0032825)3.37355924
49leukocyte migration involved in inflammatory response (GO:0002523)3.34344452
50regulation of T cell tolerance induction (GO:0002664)3.29900646
51negative regulation of nitric oxide biosynthetic process (GO:0045019)3.25471163
52activated T cell proliferation (GO:0050798)3.24827793
53defense response to protozoan (GO:0042832)3.22271906
54regulation of tolerance induction (GO:0002643)3.21333176
55natural killer cell mediated cytotoxicity (GO:0042267)3.19888901
56natural killer cell mediated immunity (GO:0002228)3.19888901
57positive regulation of interleukin-17 production (GO:0032740)3.18567507
58negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.17702163
59negative regulation of T-helper cell differentiation (GO:0045623)3.17702163
60regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.16856913
61cellular response to exogenous dsRNA (GO:0071360)3.13982302
62regulation of T cell mediated cytotoxicity (GO:0001914)3.13924186
63regulation of regulatory T cell differentiation (GO:0045589)3.12763719
64positive regulation of interferon-beta production (GO:0032728)3.11302305
65cellular response to zinc ion (GO:0071294)3.10560315
66regulation of mast cell degranulation (GO:0043304)3.10450718
67positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.10422674
68regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.09864448
69regulation of natural killer cell mediated immunity (GO:0002715)3.09864448
70leukocyte degranulation (GO:0043299)3.09685090
71regulation of B cell differentiation (GO:0045577)3.08837145
72B cell mediated immunity (GO:0019724)3.08415359
73B cell receptor signaling pathway (GO:0050853)3.08144183
74response to protozoan (GO:0001562)3.08068159
75production of molecular mediator involved in inflammatory response (GO:0002532)3.07790489
76regulation of mast cell activation (GO:0033003)3.07655556
77regulation of dendritic cell antigen processing and presentation (GO:0002604)3.06647793
78T cell migration (GO:0072678)3.06024347
79lipopolysaccharide-mediated signaling pathway (GO:0031663)3.04783478
80negative T cell selection (GO:0043383)3.04110664
81tolerance induction (GO:0002507)3.03379346
82positive regulation of gamma-delta T cell activation (GO:0046645)3.02177890
83germinal center formation (GO:0002467)3.01208945
84positive regulation of T cell mediated cytotoxicity (GO:0001916)3.01175098
85positive regulation of tolerance induction (GO:0002645)3.01092079
86positive regulation of mast cell activation (GO:0033005)3.00408685
87regulation of growth of symbiont in host (GO:0044126)3.00372505
88negative regulation of growth of symbiont in host (GO:0044130)3.00372505
89negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.00372505
90modulation of growth of symbiont involved in interaction with host (GO:0044144)3.00372505
91negative thymic T cell selection (GO:0045060)2.99477215
92negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.99365118
93reactive oxygen species biosynthetic process (GO:1903409)2.99099525
94positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.98951008
95interferon-gamma-mediated signaling pathway (GO:0060333)2.96169066
96positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.95862157
97positive thymic T cell selection (GO:0045059)2.95632530
98regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.95028067
99macrophage activation involved in immune response (GO:0002281)2.94326703
100regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.91196459
101regulation of mast cell activation involved in immune response (GO:0033006)2.91078663
102negative regulation of innate immune response (GO:0045824)2.89526862
103myeloid leukocyte mediated immunity (GO:0002444)2.88891320
104regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.88334217
105neutrophil activation (GO:0042119)2.88223288
106negative regulation of cytokine production involved in immune response (GO:0002719)2.87736084
107granulocyte activation (GO:0036230)2.87725913
108positive regulation of B cell differentiation (GO:0045579)2.86726009
109regulation of alpha-beta T cell proliferation (GO:0046640)2.86689329
110regulation of chemokine biosynthetic process (GO:0045073)2.84238264
111antigen processing and presentation via MHC class Ib (GO:0002475)2.84237134
112response to muramyl dipeptide (GO:0032495)2.83886952
113cellular response to interferon-alpha (GO:0035457)2.83419192
114response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.82678866
115response to host immune response (GO:0052572)2.82678866
116regulation of interleukin-12 biosynthetic process (GO:0045075)2.81455377
117myeloid cell activation involved in immune response (GO:0002275)2.78545624
118T-helper 1 type immune response (GO:0042088)2.78488002
119myeloid dendritic cell activation (GO:0001773)2.76898658
120regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.76412730
121negative regulation of phagocytosis (GO:0050765)2.74475256
122leukocyte mediated cytotoxicity (GO:0001909)2.71748653
123positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.69840867
124cellular response to virus (GO:0098586)2.68146233
125myeloid dendritic cell differentiation (GO:0043011)2.67034303
126actin nucleation (GO:0045010)2.66055328
127positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.65467660
128positive regulation of chemokine biosynthetic process (GO:0045080)2.64349739
129neutrophil mediated immunity (GO:0002446)2.61059106
130defense response to virus (GO:0051607)2.60800555
131ribosomal small subunit assembly (GO:0000028)2.59620466
132regulation of necroptotic process (GO:0060544)2.59564575
133negative regulation of myeloid cell apoptotic process (GO:0033033)2.59455582
134regulation of interleukin-8 biosynthetic process (GO:0045414)2.58783554
135response to fungus (GO:0009620)2.57860092
136regulation of natural killer cell differentiation (GO:0032823)2.55334561
137response to host (GO:0075136)2.54974546
138response to host defenses (GO:0052200)2.54974546
139response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.54974546
140hydrogen peroxide biosynthetic process (GO:0050665)2.54889248
141regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53859294
142positive regulation of response to biotic stimulus (GO:0002833)2.47120256
143detection of molecule of bacterial origin (GO:0032490)2.44690312
144dendritic cell differentiation (GO:0097028)2.44054180
145angiogenesis involved in wound healing (GO:0060055)2.44052197
146purine-containing compound salvage (GO:0043101)2.43020235
147positive regulation of antigen processing and presentation (GO:0002579)2.42447380
148antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.41312538
149positive regulation of type I interferon production (GO:0032481)2.39520326
150superoxide anion generation (GO:0042554)2.39363401
151cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.38558351
152regulation of B cell receptor signaling pathway (GO:0050855)2.36837874
153myeloid leukocyte activation (GO:0002274)2.35678217
154positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.35415506
155NIK/NF-kappaB signaling (GO:0038061)2.35317218

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.79945762
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.69677660
3* IRF8_21731497_ChIP-ChIP_J774_Mouse4.58858941
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.93190410
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.72866272
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.27032648
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.09828298
8MYB_21317192_ChIP-Seq_ERMYB_Mouse3.05686203
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.03246153
10RUNX_20019798_ChIP-Seq_JUKART_Human2.84685316
11* IRF8_27001747_Chip-Seq_BMDM_Mouse2.83363536
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.76337081
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69475220
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64662324
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.51373581
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.41274799
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.40258889
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31401209
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.28765656
20SCL_19346495_ChIP-Seq_HPC-7_Human2.18953450
21* SPI1_23547873_ChIP-Seq_NB4_Human2.14966902
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06026426
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05899670
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03868371
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.99610961
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99399504
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.98013425
28VDR_24787735_ChIP-Seq_THP-1_Human1.97516543
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96591088
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90727657
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83664917
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83177769
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81968400
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78607985
35GATA1_22025678_ChIP-Seq_K562_Human1.76764610
36VDR_21846776_ChIP-Seq_THP-1_Human1.75327913
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72183345
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69317946
39MYB_26560356_Chip-Seq_TH2_Human1.68684452
40* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66631108
41VDR_24763502_ChIP-Seq_THP-1_Human1.63282827
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.62414688
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53071227
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.50105761
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48749721
46MYB_26560356_Chip-Seq_TH1_Human1.46755708
47MAF_26560356_Chip-Seq_TH1_Human1.46637052
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46169451
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42780193
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42512547
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38361602
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38006659
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.36417009
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36246036
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34734869
56PU_27001747_Chip-Seq_BMDM_Mouse1.33549900
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31492721
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31305503
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.28256998
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27741406
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26775875
62MYC_22102868_ChIP-Seq_BL_Human1.26755069
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26722525
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26477842
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24744603
66TCF7_22412390_ChIP-Seq_EML_Mouse1.23239393
67* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22414255
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.22152626
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19285852
70UTX_26944678_Chip-Seq_JUKART_Human1.17104315
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16430227
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14712636
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13975260
74* NOTCH1_21737748_ChIP-Seq_TLL_Human1.13802172
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.13561442
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13482027
77TFEB_21752829_ChIP-Seq_HELA_Human1.12878223
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12707677
79GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12394575
80ELK1_19687146_ChIP-ChIP_HELA_Human1.11766342
81SPI1_23127762_ChIP-Seq_K562_Human1.11119688
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09251497
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07449823
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07183794
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06163753
86GABP_17652178_ChIP-ChIP_JURKAT_Human1.05297237
87MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04767419
88EST1_17652178_ChIP-ChIP_JURKAT_Human1.04691330
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.04624885
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04454017
91VDR_23849224_ChIP-Seq_CD4+_Human1.04293369
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03190123
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02585709
94FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02491598
95KDM2B_26808549_Chip-Seq_DND41_Human1.01484595
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01333445
97GATA1_19941826_ChIP-Seq_K562_Human1.00896538
98ELK3_25401928_ChIP-Seq_HUVEC_Human0.98735001
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98673363
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97814483
101DCP1A_22483619_ChIP-Seq_HELA_Human0.97306890
102RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97091227
103TP63_17297297_ChIP-ChIP_HaCaT_Human0.96878030
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95935394
105SRF_21415370_ChIP-Seq_HL-1_Mouse0.94643351
106AR_21909140_ChIP-Seq_LNCAP_Human0.94563155
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93985078
108CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93885225
109NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92835420
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92465659
111RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91928738
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90808995
113MAF_26560356_Chip-Seq_TH2_Human0.89698549
114GATA3_26560356_Chip-Seq_TH2_Human0.89622614
115BCL6_27268052_Chip-Seq_Bcells_Human0.89543991
116NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89513043
117IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88891064
118GATA2_19941826_ChIP-Seq_K562_Human0.87942389
119PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87847383
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87803963
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86624516
122GATA3_27048872_Chip-Seq_THYMUS_Human0.86426882
123FOXP3_21729870_ChIP-Seq_TREG_Human0.86214035
124SMRT_27268052_Chip-Seq_Bcells_Human0.86121360
125MYC_19030024_ChIP-ChIP_MESCs_Mouse0.85800877
126TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85596577
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84941562
128STAT1_20625510_ChIP-Seq_HELA_Human0.79832188
129BCOR_27268052_Chip-Seq_Bcells_Human0.79370010
130STAT6_21828071_ChIP-Seq_BEAS2B_Human0.76366681
131RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72847238
132* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72838207
133RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70616297
134SPI1_20517297_ChIP-Seq_HL60_Human0.69844491
135GATA3_26560356_Chip-Seq_TH1_Human0.68708292
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66716253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.86178027
2MP0009785_altered_susceptibility_to3.44602395
3MP0003436_decreased_susceptibility_to3.00290807
4MP0003724_increased_susceptibility_to2.91613161
5MP0002148_abnormal_hypersensitivity_rea2.85167100
6MP0002419_abnormal_innate_immunity2.62916128
7MP0005025_abnormal_response_to2.61961720
8MP0005000_abnormal_immune_tolerance2.42539958
9MP0000685_abnormal_immune_system2.35691689
10MP0001853_heart_inflammation2.31309890
11MP0005671_abnormal_response_to2.28627840
12MP0002452_abnormal_antigen_presenting2.20846739
13MP0003303_peritoneal_inflammation2.18698386
14MP0002396_abnormal_hematopoietic_system2.16708922
15MP0005464_abnormal_platelet_physiology2.13566865
16MP0005387_immune_system_phenotype2.08785797
17MP0001790_abnormal_immune_system2.08785797
18MP0002723_abnormal_immune_serum2.05132208
19MP0010352_gastrointestinal_tract_polyps2.04508080
20MP0001800_abnormal_humoral_immune2.03587230
21MP0002166_altered_tumor_susceptibility2.03131457
22MP0003191_abnormal_cellular_cholesterol2.01821329
23MP0008438_abnormal_cutaneous_collagen2.01219390
24MP0006082_CNS_inflammation1.98611510
25MP0001819_abnormal_immune_cell1.94380328
26MP0002420_abnormal_adaptive_immunity1.92670345
27MP0001533_abnormal_skeleton_physiology1.90953315
28MP0010155_abnormal_intestine_physiology1.90584252
29MP0002006_tumorigenesis1.88746575
30MP0004808_abnormal_hematopoietic_stem1.87174561
31MP0010307_abnormal_tumor_latency1.86465298
32MP0005397_hematopoietic_system_phenotyp1.84880411
33MP0001545_abnormal_hematopoietic_system1.84880411
34MP0000343_altered_response_to1.74230123
35MP0006054_spinal_hemorrhage1.64018004
36MP0000858_altered_metastatic_potential1.63827535
37MP0003705_abnormal_hypodermis_morpholog1.62868792
38MP0009333_abnormal_splenocyte_physiolog1.62489473
39MP0002398_abnormal_bone_marrow1.62464705
40MP0001845_abnormal_inflammatory_respons1.62364460
41MP0003448_altered_tumor_morphology1.62281642
42MP0005058_abnormal_lysosome_morphology1.60078002
43MP0004947_skin_inflammation1.58312457
44MP0000490_abnormal_crypts_of1.58115504
45MP0009764_decreased_sensitivity_to1.57244435
46MP0002405_respiratory_system_inflammati1.53709659
47MP0000716_abnormal_immune_system1.52928705
48MP0008469_abnormal_protein_level1.51627447
49MP0008260_abnormal_autophagy1.49254694
50MP0003186_abnormal_redox_activity1.45693275
51MP0003172_abnormal_lysosome_physiology1.45684674
52MP0009278_abnormal_bone_marrow1.43688909
53MP0003183_abnormal_peptide_metabolism1.41735796
54MP0005451_abnormal_body_composition1.41719222
55MP0002429_abnormal_blood_cell1.36826921
56MP0000689_abnormal_spleen_morphology1.34934298
57MP0002877_abnormal_melanocyte_morpholog1.31781162
58MP0003300_gastrointestinal_ulcer1.30327170
59MP0002138_abnormal_hepatobiliary_system1.29636249
60MP0002277_abnormal_respiratory_mucosa1.28280415
61MP0000569_abnormal_digit_pigmentation1.27801572
62MP0002722_abnormal_immune_system1.27494491
63MP0003806_abnormal_nucleotide_metabolis1.25952668
64MP0004883_abnormal_blood_vessel1.25334374
65MP0002132_abnormal_respiratory_system1.23894803
66MP0005023_abnormal_wound_healing1.21361364
67MP0003566_abnormal_cell_adhesion1.20188649
68MP0005174_abnormal_tail_pigmentation1.19942011
69MP0003693_abnormal_embryo_hatching1.19677357
70MP0003763_abnormal_thymus_physiology1.15732815
71MP0009840_abnormal_foam_cell1.13361360
72MP0003075_altered_response_to1.12016980
73MP0009763_increased_sensitivity_to1.10407408
74MP0004381_abnormal_hair_follicle1.09972361
75MP0005164_abnormal_response_to1.09002416
76MP0008007_abnormal_cellular_replicative1.07636619
77MP0004510_myositis1.06014847
78MP0002998_abnormal_bone_remodeling1.00519009
79MP0001663_abnormal_digestive_system0.99906349
80MP0000465_gastrointestinal_hemorrhage0.99499336
81MP0001873_stomach_inflammation0.99375841
82MP0002019_abnormal_tumor_incidence0.98003098
83MP0003279_aneurysm0.97224571
84MP0005390_skeleton_phenotype0.92308722
85MP0000249_abnormal_blood_vessel0.89599042
86MP0003091_abnormal_cell_migration0.88257386
87MP0001879_abnormal_lymphatic_vessel0.86671942
88MP0005360_urolithiasis0.85387559
89MP0005166_decreased_susceptibility_to0.85159490
90MP0003828_pulmonary_edema0.85009750
91MP0010094_abnormal_chromosome_stability0.84883352
92MP0001851_eye_inflammation0.84821483
93MP0003656_abnormal_erythrocyte_physiolo0.84548589
94MP0001958_emphysema0.84267330
95MP0005167_abnormal_blood-brain_barrier0.83576748
96MP0003045_fibrosis0.82726963
97MP0010368_abnormal_lymphatic_system0.82012583
98MP0003690_abnormal_glial_cell0.81368575
99MP0005310_abnormal_salivary_gland0.80006560
100MP0004782_abnormal_surfactant_physiolog0.79864125
101MP0005408_hypopigmentation0.79693548
102MP0003866_abnormal_defecation0.79204747
103MP0002332_abnormal_exercise_endurance0.79036659
104MP0001986_abnormal_taste_sensitivity0.78986469
105MP0003077_abnormal_cell_cycle0.78961539
106MP0000703_abnormal_thymus_morphology0.78172506
107MP0008004_abnormal_stomach_pH0.77661971
108MP0002933_joint_inflammation0.75096965
109MP0000371_diluted_coat_color0.72356170
110MP0009697_abnormal_copulation0.72013301
111MP0000604_amyloidosis0.71009126
112MP0003221_abnormal_cardiomyocyte_apopto0.70573724
113MP0000015_abnormal_ear_pigmentation0.70410420
114MP0001915_intracranial_hemorrhage0.69812264
115MP0009765_abnormal_xenobiotic_induced0.68671907
116MP0005075_abnormal_melanosome_morpholog0.68653932
117MP0003111_abnormal_nucleus_morphology0.67745403
118MP0008873_increased_physiological_sensi0.67640071
119MP0000372_irregular_coat_pigmentation0.67523119
120MP0005275_abnormal_skin_tensile0.67082372
121MP0005319_abnormal_enzyme/_coenzyme0.63380766
122MP0003795_abnormal_bone_structure0.62053707
123MP0002693_abnormal_pancreas_physiology0.57984844
124MP0008874_decreased_physiological_sensi0.53195482
125MP0005376_homeostasis/metabolism_phenot0.53144391
126MP0000609_abnormal_liver_physiology0.50559147
127MP0005381_digestive/alimentary_phenotyp0.49781776
128MP0002136_abnormal_kidney_physiology0.49033923

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.18093706
2Elevated erythrocyte sedimentation rate (HP:0003565)5.01385850
3Eczematoid dermatitis (HP:0000976)4.72296673
4Recurrent bacterial skin infections (HP:0005406)4.64824531
5Thrombocytosis (HP:0001894)4.23874072
6Abnormal delayed hypersensitivity skin test (HP:0002963)4.14018524
7Myositis (HP:0100614)4.03404522
8Keratoconjunctivitis sicca (HP:0001097)4.00328171
9Recurrent gram-negative bacterial infections (HP:0005420)3.92329766
10Autoimmune thrombocytopenia (HP:0001973)3.89287924
11Keratoconjunctivitis (HP:0001096)3.83224190
12Chronic otitis media (HP:0000389)3.71765479
13Encephalitis (HP:0002383)3.71640048
14Abnormality of macrophages (HP:0004311)3.68883532
15Vacuolated lymphocytes (HP:0001922)3.67295928
16Mediastinal lymphadenopathy (HP:0100721)3.56140921
17T lymphocytopenia (HP:0005403)3.53067006
18Abnormality of T cell number (HP:0011839)3.51698091
19Petechiae (HP:0000967)3.41576965
20Basal ganglia calcification (HP:0002135)3.04681838
21Orchitis (HP:0100796)3.03589547
22Recurrent viral infections (HP:0004429)3.01124490
23Interstitial pulmonary disease (HP:0006530)2.95036646
24Recurrent skin infections (HP:0001581)2.94122814
25Periodontitis (HP:0000704)2.92631867
26Anorexia (HP:0002039)2.88304543
27Episodic fever (HP:0001954)2.83864632
28Vasculitis (HP:0002633)2.83842980
29Abnormality of liposaccharide metabolism (HP:0010968)2.78674440
30Abnormality of glycosphingolipid metabolism (HP:0004343)2.78674440
31Abnormality of glycolipid metabolism (HP:0010969)2.78674440
32Recurrent fungal infections (HP:0002841)2.77911069
33Increased IgE level (HP:0003212)2.77170476
34Chronic obstructive pulmonary disease (HP:0006510)2.74954257
35Obstructive lung disease (HP:0006536)2.74954257
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.74741368
37Hypergammaglobulinemia (HP:0010702)2.74159060
38Epistaxis (HP:0000421)2.72426069
39Inflammation of the large intestine (HP:0002037)2.72034017
40Increased cerebral lipofuscin (HP:0011813)2.70828174
41Cellulitis (HP:0100658)2.69674214
42Panhypogammaglobulinemia (HP:0003139)2.68852392
43Poor head control (HP:0002421)2.67704471
44Pulmonary embolism (HP:0002204)2.65333621
45Gangrene (HP:0100758)2.64565370
46Gingival bleeding (HP:0000225)2.63876208
47Hypochromic anemia (HP:0001931)2.61011662
48Abnormality of the prostate (HP:0008775)2.59896219
49Purpura (HP:0000979)2.59769785
50Gingivitis (HP:0000230)2.57823283
51Systemic lupus erythematosus (HP:0002725)2.55822741
52Recurrent bronchitis (HP:0002837)2.55431281
53Gastrointestinal inflammation (HP:0004386)2.54057396
54Hypochromic microcytic anemia (HP:0004840)2.53387928
55Joint hemorrhage (HP:0005261)2.51863057
56Prolonged bleeding time (HP:0003010)2.50976996
57Abnormality of the pleura (HP:0002103)2.48829078
58Abnormality of the nasal mucosa (HP:0000433)2.46226832
59Arterial thrombosis (HP:0004420)2.45426433
60Pulmonary infiltrates (HP:0002113)2.45296050
61Spontaneous hematomas (HP:0007420)2.43832247
62Abnormality of T cell physiology (HP:0011840)2.43243226
63Osteolytic defects of the phalanges of the hand (HP:0009771)2.42307588
64Osteolytic defects of the hand bones (HP:0009699)2.42307588
65Vertebral compression fractures (HP:0002953)2.42135651
66Subacute progressive viral hepatitis (HP:0006572)2.39676840
67Nasal polyposis (HP:0100582)2.39414601
68Amyloidosis (HP:0011034)2.38189063
69Optic neuritis (HP:0100653)2.37670406
70Retrobulbar optic neuritis (HP:0100654)2.37670406
71Osteomyelitis (HP:0002754)2.36698520
72Tetraparesis (HP:0002273)2.33806586
73Chronic diarrhea (HP:0002028)2.32391315
74Hematochezia (HP:0002573)2.29407651
75Abnormality of B cell number (HP:0010975)2.29250594
76Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.29179781
77Stomach cancer (HP:0012126)2.27706844
78Reduced antithrombin III activity (HP:0001976)2.26748982
79Pustule (HP:0200039)2.26567617
80Lymphopenia (HP:0001888)2.26308854
81Abnormality of the endocardium (HP:0004306)2.25749431
82Abnormal platelet volume (HP:0011876)2.25092572
83Peritonitis (HP:0002586)2.25008276
84Cutaneous melanoma (HP:0012056)2.23928584
85Meningitis (HP:0001287)2.22573105
86Keratitis (HP:0000491)2.19633483
87Micronodular cirrhosis (HP:0001413)2.18866774
88Increased IgM level (HP:0003496)2.18782331
89Autoimmune hemolytic anemia (HP:0001890)2.18658831
90Chest pain (HP:0100749)2.18616971
91Abnormality of cells of the lymphoid lineage (HP:0012140)2.18536424
92Abnormality of eosinophils (HP:0001879)2.18118987
93Abnormality of the pericardium (HP:0001697)2.17690216
94Cervical subluxation (HP:0003308)2.17387968
95Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16737228
96Abnormality of iron homeostasis (HP:0011031)2.15659530
97Hepatosplenomegaly (HP:0001433)2.15355915
98Glomerulopathy (HP:0100820)2.14737047
99Cheilitis (HP:0100825)2.14675591
100Spinal cord lesions (HP:0100561)2.13994698
101Syringomyelia (HP:0003396)2.13994698
102Leukocytosis (HP:0001974)2.12479935
103Urticaria (HP:0001025)2.11848021
104Vertigo (HP:0002321)2.11221312
105Hemoptysis (HP:0002105)2.11169708
106IgM deficiency (HP:0002850)2.11160427
107Polyneuropathy (HP:0001271)2.10993234
108Nausea (HP:0002018)2.10706862
109Prostate neoplasm (HP:0100787)2.09959322
110Sepsis (HP:0100806)2.08591093
111Loss of speech (HP:0002371)2.08378513
112Abnormal platelet function (HP:0011869)2.06452723
113Impaired platelet aggregation (HP:0003540)2.06452723
114Increased mean platelet volume (HP:0011877)2.04146003
115Skin ulcer (HP:0200042)2.03917663
116IgG deficiency (HP:0004315)2.02942011
117Agammaglobulinemia (HP:0004432)1.99631237
118Abnormality of T cells (HP:0002843)1.98469662
119Acute hepatic failure (HP:0006554)1.97931820
120Protrusio acetabuli (HP:0003179)1.97447428
121Viral hepatitis (HP:0006562)1.95555503
122Abnormality of the peritoneum (HP:0002585)1.95532441
123Albinism (HP:0001022)1.94046727
124Gastrointestinal infarctions (HP:0005244)1.93650116
125Microcytic anemia (HP:0001935)1.92247925
126Stomatitis (HP:0010280)1.91182403
127Amaurosis fugax (HP:0100576)1.91062291
128Acne (HP:0001061)1.90682182
129Abnormality of transition element cation homeostasis (HP:0011030)1.90224613
130Thoracic kyphosis (HP:0002942)1.89736174
131Granulocytopenia (HP:0001913)1.89725198
132Skin rash (HP:0000988)1.88931561
133Eosinophilia (HP:0001880)1.88916977
134Abnormality of the common coagulation pathway (HP:0010990)1.88689063
135Axonal loss (HP:0003447)1.88598742
136Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88012698
137Recurrent lower respiratory tract infections (HP:0002783)1.87696334
138Increased serum ferritin (HP:0003281)1.87601972
139Reduced subcutaneous adipose tissue (HP:0003758)1.87113925
140Bruising susceptibility (HP:0000978)1.86649583
141Recurrent pneumonia (HP:0006532)1.86635351
142Nonimmune hydrops fetalis (HP:0001790)1.85929239
143Recurrent cutaneous fungal infections (HP:0011370)1.85778401
144Chronic mucocutaneous candidiasis (HP:0002728)1.85778401
145Reticulocytopenia (HP:0001896)1.85761654
146Myocardial infarction (HP:0001658)1.85406177
147IgA deficiency (HP:0002720)1.84284083

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TBK13.14234010
2PIM23.11393356
3KIT3.00033485
4IRAK42.79459670
5TYK22.72160347
6MAP3K142.61058785
7NME22.56889446
8BLK2.56405480
9MAP4K12.48954701
10IRAK32.41220691
11IKBKE2.37962599
12JAK32.18976881
13ERN12.17805425
14NEK92.08178539
15GRK62.02057393
16TNK21.98768835
17TEC1.93931566
18PKN21.77056774
19FGR1.74837177
20IKBKB1.72369133
21RPS6KA41.64305451
22MAP2K31.58226619
23JAK11.52708492
24MAP3K31.51517220
25TAOK11.50061506
26FLT31.48352640
27ZAP701.46961455
28MST1R1.45954178
29BTK1.43604654
30TAOK31.41996162
31PIM11.41460958
32KDR1.39474378
33PRPF4B1.37860368
34BMPR21.35859393
35CSF1R1.31970292
36TGFBR11.31690004
37PBK1.30327711
38ABL21.27356549
39EIF2AK31.26259482
40FRK1.25545090
41TRIB31.19192053
42TXK1.16960806
43WEE11.16441903
44LRRK21.16076080
45SIK31.15953988
46RIPK41.15816496
47SYK1.11880271
48MATK1.10101855
49TRPM71.09696186
50STK101.08621673
51EIF2AK21.07231560
52MAP3K11.05017264
53KSR21.01127020
54VRK11.00464712
55ACVR1B0.99242866
56CHUK0.95582732
57YES10.94869448
58IRAK20.92879933
59GRK70.92197382
60BMX0.92170803
61MAP2K60.91328475
62TESK10.91221831
63LYN0.90849762
64HCK0.86680310
65STK40.86529113
66EPHA30.86214537
67PTK2B0.86167519
68FES0.84763112
69BRSK20.84230558
70EIF2AK10.83686849
71EPHB10.83500582
72ADRBK20.83129599
73LCK0.82920200
74TGFBR20.81524414
75MAP3K50.79697143
76PAK40.78834727
77SCYL20.77967805
78ARAF0.77807613
79PDK10.77750894
80STK160.77210804
81MARK30.75758652
82TTN0.75732610
83CSK0.75396433
84CDC70.72395623
85SIK20.70693215
86FGFR40.70527167
87PTK60.69537709
88PIK3CG0.69280131
89EEF2K0.69206772
90PRKCQ0.69086038
91ATR0.68827711
92MAP3K80.66143180
93MAP3K130.66080268
94TAOK20.65945045
95CDK40.64418106
96RIPK10.64367733
97PRKD20.64011152
98RAF10.62349562
99CDC42BPA0.62149961
100MAP3K110.61477692
101PDPK10.60969425
102JAK20.60908475
103HIPK20.58362145
104PRKG20.57735202
105MARK20.56059723
106ABL10.56020754
107MAP3K60.55806386
108CDK60.55785013
109MST40.53768716
110TESK20.53248323
111STK30.53023375
112FYN0.52330644
113FGFR30.52284888
114MAPK70.51294591
115RPS6KA60.49620500
116MAP3K120.49597690
117KSR10.49518566
118NLK0.48415529
119AURKB0.46494112
120CDK70.45883967
121MAP3K70.45530550
122IRAK10.44473055
123CAMKK20.44025298
124MAPKAPK30.43688176
125MKNK10.43602787
126NEK20.41813559
127PRKCD0.40929131
128RPS6KB20.39992697
129ADRBK10.38915097
130PRKAA20.38795085
131TIE10.38722605
132MAPK120.38632224
133MAPK40.37878375
134MAPKAPK20.37354891
135MAPK110.36567400
136CLK10.35386069
137ITK0.35269520
138STK110.34007329
139DAPK20.33717219
140SGK30.29829203
141TLK10.29034248
142MAP3K20.28032454
143PRKCZ0.25821706
144RPS6KC10.21412663

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.98456137
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.87945097
3DNA replication_Homo sapiens_hsa030302.54845091
4RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.45004063
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.44557609
6Allograft rejection_Homo sapiens_hsa053302.30626814
7Measles_Homo sapiens_hsa051622.11621629
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.04154030
9Legionellosis_Homo sapiens_hsa051341.99593192
10Malaria_Homo sapiens_hsa051441.97030189
11Pertussis_Homo sapiens_hsa051331.94088298
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90493819
13Staphylococcus aureus infection_Homo sapiens_hsa051501.89652198
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.83815150
15Graft-versus-host disease_Homo sapiens_hsa053321.83768547
16Herpes simplex infection_Homo sapiens_hsa051681.81675517
17Antigen processing and presentation_Homo sapiens_hsa046121.79950814
18T cell receptor signaling pathway_Homo sapiens_hsa046601.78153296
19Osteoclast differentiation_Homo sapiens_hsa043801.72368643
20Influenza A_Homo sapiens_hsa051641.71551309
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68091019
22Tuberculosis_Homo sapiens_hsa051521.56188795
23Proteasome_Homo sapiens_hsa030501.55174370
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53932409
25Toxoplasmosis_Homo sapiens_hsa051451.53470488
26Shigellosis_Homo sapiens_hsa051311.48367773
27Apoptosis_Homo sapiens_hsa042101.47284758
28Asthma_Homo sapiens_hsa053101.46251989
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43463949
30* TNF signaling pathway_Homo sapiens_hsa046681.43319440
31Other glycan degradation_Homo sapiens_hsa005111.42019643
32Base excision repair_Homo sapiens_hsa034101.36203947
33Salmonella infection_Homo sapiens_hsa051321.31269086
34Hematopoietic cell lineage_Homo sapiens_hsa046401.28607906
35Viral myocarditis_Homo sapiens_hsa054161.26407068
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.22310291
37Ribosome_Homo sapiens_hsa030101.20995123
38Caffeine metabolism_Homo sapiens_hsa002321.19560329
39Mismatch repair_Homo sapiens_hsa034301.19547213
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.16969497
41Hepatitis B_Homo sapiens_hsa051611.16561473
42B cell receptor signaling pathway_Homo sapiens_hsa046621.13253759
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11007071
44Lysosome_Homo sapiens_hsa041421.10761747
45Phagosome_Homo sapiens_hsa041451.09662296
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08323152
47Primary immunodeficiency_Homo sapiens_hsa053401.07700219
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06523293
49Homologous recombination_Homo sapiens_hsa034401.04090575
50Pentose phosphate pathway_Homo sapiens_hsa000301.01324982
51Rheumatoid arthritis_Homo sapiens_hsa053231.00891838
52Type I diabetes mellitus_Homo sapiens_hsa049401.00392197
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00114509
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96957669
55Pyrimidine metabolism_Homo sapiens_hsa002400.95990221
56One carbon pool by folate_Homo sapiens_hsa006700.92433019
57Autoimmune thyroid disease_Homo sapiens_hsa053200.90472471
58Hepatitis C_Homo sapiens_hsa051600.89954915
59p53 signaling pathway_Homo sapiens_hsa041150.89924404
60Small cell lung cancer_Homo sapiens_hsa052220.88610348
61Nucleotide excision repair_Homo sapiens_hsa034200.85504288
62African trypanosomiasis_Homo sapiens_hsa051430.84587062
63Platelet activation_Homo sapiens_hsa046110.83780439
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82681194
65VEGF signaling pathway_Homo sapiens_hsa043700.80819009
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80566762
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.78977396
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78809232
69Epstein-Barr virus infection_Homo sapiens_hsa051690.78400262
70Galactose metabolism_Homo sapiens_hsa000520.78265723
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77518654
72Prolactin signaling pathway_Homo sapiens_hsa049170.75725154
73Acute myeloid leukemia_Homo sapiens_hsa052210.75143511
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73779531
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73602715
76Chronic myeloid leukemia_Homo sapiens_hsa052200.73325558
77Viral carcinogenesis_Homo sapiens_hsa052030.71258924
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70901189
79Non-small cell lung cancer_Homo sapiens_hsa052230.70888978
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70400684
81Dorso-ventral axis formation_Homo sapiens_hsa043200.69401416
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68175404
83N-Glycan biosynthesis_Homo sapiens_hsa005100.66646675
84Chemokine signaling pathway_Homo sapiens_hsa040620.65032346
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64589053
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63665216
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63508078
88Complement and coagulation cascades_Homo sapiens_hsa046100.62496811
89Cell cycle_Homo sapiens_hsa041100.62215556
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61531318
91Systemic lupus erythematosus_Homo sapiens_hsa053220.60288072
92Amoebiasis_Homo sapiens_hsa051460.60069021
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.59295902
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.58653780
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.57447640
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54802896
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54415816
98Non-homologous end-joining_Homo sapiens_hsa034500.53934161
99HIF-1 signaling pathway_Homo sapiens_hsa040660.53682430
100FoxO signaling pathway_Homo sapiens_hsa040680.52756139
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52036875
102Endocytosis_Homo sapiens_hsa041440.51922628
103Renin-angiotensin system_Homo sapiens_hsa046140.51719958
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51515847
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.47741630
106Folate biosynthesis_Homo sapiens_hsa007900.46980198
107Pancreatic cancer_Homo sapiens_hsa052120.46085641
108Insulin resistance_Homo sapiens_hsa049310.45604598
109Renal cell carcinoma_Homo sapiens_hsa052110.44264146
110HTLV-I infection_Homo sapiens_hsa051660.41688547
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41317121
112Arachidonic acid metabolism_Homo sapiens_hsa005900.39903210
113Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39890445
114Starch and sucrose metabolism_Homo sapiens_hsa005000.38731340
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.38709533
116Ether lipid metabolism_Homo sapiens_hsa005650.38382842
117Selenocompound metabolism_Homo sapiens_hsa004500.37596813
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37558044
119Regulation of autophagy_Homo sapiens_hsa041400.37214118
120Glutathione metabolism_Homo sapiens_hsa004800.37127094
121Protein export_Homo sapiens_hsa030600.36885290
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.36745157
123MAPK signaling pathway_Homo sapiens_hsa040100.36594689
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35768164
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35754337
126Collecting duct acid secretion_Homo sapiens_hsa049660.34909345
127GnRH signaling pathway_Homo sapiens_hsa049120.32826471
128Choline metabolism in cancer_Homo sapiens_hsa052310.31320228
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26239596
130Type II diabetes mellitus_Homo sapiens_hsa049300.23768840
131Linoleic acid metabolism_Homo sapiens_hsa005910.23424592
132Notch signaling pathway_Homo sapiens_hsa043300.22426136
133Inositol phosphate metabolism_Homo sapiens_hsa005620.22334145

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