ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	6.86740737
2	piRNA metabolic process (GO:0034587)	6.56569471
3	inositol phosphate catabolic process (GO:0071545)	5.58268457
4	phosphorylated carbohydrate dephosphorylation (GO:0046838)	5.57911202
5	inositol phosphate dephosphorylation (GO:0046855)	5.57911202
6	DNA methylation involved in gamete generation (GO:0043046)	5.50039187
7	platelet dense granule organization (GO:0060155)	4.51301284
8	mitotic sister chromatid cohesion (GO:0007064)	4.38612200
9	dopamine transport (GO:0015872)	4.26750791
10	polyol catabolic process (GO:0046174)	4.21919636
11	cullin deneddylation (GO:0010388)	4.17294471
12	iron ion import (GO:0097286)	4.13555075
13	replication fork processing (GO:0031297)	4.00440933
14	chromosome organization involved in meiosis (GO:0070192)	3.93996750
15	DNA deamination (GO:0045006)	3.90921144
16	male meiosis (GO:0007140)	3.78754053
17	protein-chromophore linkage (GO:0018298)	3.78362515
18	male meiosis I (GO:0007141)	3.76184876
19	protein deneddylation (GO:0000338)	3.74554220
20	folic acid-containing compound biosynthetic process (GO:0009396)	3.66517103
21	protein K11-linked deubiquitination (GO:0035871)	3.65643792
22	lactate metabolic process (GO:0006089)	3.62898929
23	negative regulation of exocytosis (GO:0045920)	3.59150360
24	regulation of glucokinase activity (GO:0033131)	3.54950820
25	regulation of hexokinase activity (GO:1903299)	3.54950820
26	peptidyl-histidine modification (GO:0018202)	3.47734671
27	protein targeting to Golgi (GO:0000042)	3.44827690
28	maturation of 5.8S rRNA (GO:0000460)	3.41423438
29	DNA replication-dependent nucleosome assembly (GO:0006335)	3.40255934
30	DNA replication-dependent nucleosome organization (GO:0034723)	3.40255934
31	signal peptide processing (GO:0006465)	3.39605270
32	gonadal mesoderm development (GO:0007506)	3.37300321
33	cardiac left ventricle morphogenesis (GO:0003214)	3.34242081
34	establishment of protein localization to Golgi (GO:0072600)	3.32396831
35	microtubule nucleation (GO:0007020)	3.29089987
36	transcription from mitochondrial promoter (GO:0006390)	3.29047222
37	meiotic chromosome segregation (GO:0045132)	3.28453130
38	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.28089904
39	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.28089904
40	proline transport (GO:0015824)	3.26675532
41	cellular ketone body metabolic process (GO:0046950)	3.24009272
42	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.23082084
43	pteridine-containing compound biosynthetic process (GO:0042559)	3.22440765
44	inositol metabolic process (GO:0006020)	3.20659603
45	regulation of meiosis I (GO:0060631)	3.18908639
46	retinol metabolic process (GO:0042572)	3.17266911
47	sister chromatid cohesion (GO:0007062)	3.11447678
48	transcytosis (GO:0045056)	3.08855949
49	regulation of mitotic spindle checkpoint (GO:1903504)	3.08512050
50	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.08512050
51	succinate metabolic process (GO:0006105)	3.08143992
52	water-soluble vitamin biosynthetic process (GO:0042364)	3.07016291
53	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.06928024
54	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.06928024
55	resolution of meiotic recombination intermediates (GO:0000712)	3.05704142
56	DNA double-strand break processing (GO:0000729)	3.03296101
57	positive regulation of meiosis (GO:0045836)	3.01890450
58	histone H4-K8 acetylation (GO:0043982)	3.00421734
59	histone H4-K5 acetylation (GO:0043981)	3.00421734
60	ribonucleoprotein complex disassembly (GO:0032988)	2.99839954
61	ncRNA 3-end processing (GO:0043628)	2.97039030
62	rhodopsin mediated signaling pathway (GO:0016056)	2.95617624
63	tachykinin receptor signaling pathway (GO:0007217)	2.95610338
64	ketone body metabolic process (GO:1902224)	2.92625074
65	DNA synthesis involved in DNA repair (GO:0000731)	2.90937408
66	energy homeostasis (GO:0097009)	2.90770774
67	intra-Golgi vesicle-mediated transport (GO:0006891)	2.89535028
68	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.88829873
69	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.88829873
70	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.84942686
71	gene silencing by RNA (GO:0031047)	2.84394547
72	regulation of protein glycosylation (GO:0060049)	2.84098911
73	meiotic nuclear division (GO:0007126)	2.81447131
74	mannosylation (GO:0097502)	2.80882043
75	reciprocal meiotic recombination (GO:0007131)	2.80570975
76	reciprocal DNA recombination (GO:0035825)	2.80570975
77	protein localization to Golgi apparatus (GO:0034067)	2.79929309
78	positive regulation of heat generation (GO:0031652)	2.78833645
79	response to misfolded protein (GO:0051788)	2.78387727
80	righting reflex (GO:0060013)	2.77974316
81	positive regulation of meiotic cell cycle (GO:0051446)	2.77453037
82	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.73761497
83	inositol phosphate-mediated signaling (GO:0048016)	2.73518977
84	positive regulation of respiratory burst (GO:0060267)	2.71610041
85	zinc ion homeostasis (GO:0055069)	2.69343444
86	behavioral response to nicotine (GO:0035095)	2.69277278
87	negative regulation of acute inflammatory response (GO:0002674)	2.66319714
88	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.64777921
89	protein-cofactor linkage (GO:0018065)	2.64654497
90	retinal cone cell development (GO:0046549)	2.62678313
91	insulin secretion (GO:0030073)	2.61089995
92	detection of calcium ion (GO:0005513)	2.60564352
93	protein K11-linked ubiquitination (GO:0070979)	2.57743119
94	meiotic cell cycle (GO:0051321)	2.55744532
95	heart process (GO:0003015)	2.55109770
96	heart contraction (GO:0060047)	2.55109770
97	negative regulation of mast cell activation (GO:0033004)	2.53454584
98	vitamin transmembrane transport (GO:0035461)	2.52442527
99	meiosis I (GO:0007127)	2.51887565
100	centriole assembly (GO:0098534)	2.51673551

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.73507245
2	VDR_22108803_ChIP-Seq_LS180_Human	3.20947578
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.19770029
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.19304060
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.05209423
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.73444294
7	FUS_26573619_Chip-Seq_HEK293_Human	2.59633628
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.37777050
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.20254011
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.13140272
11	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.10652626
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.10143584
13	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.09918758
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.05266489
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.01139903
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.93947384
17	TP53_22573176_ChIP-Seq_HFKS_Human	1.88397505
18	ELK1_19687146_ChIP-ChIP_HELA_Human	1.84265430
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83731571
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.83357436
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.83207860
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.71858022
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.71317466
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.63571641
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.60691797
26	GBX2_23144817_ChIP-Seq_PC3_Human	1.60333902
27	STAT3_23295773_ChIP-Seq_U87_Human	1.59368383
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58982328
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.57342545
30	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.56075904
31	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.56075904
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55883402
33	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.54070056
34	HTT_18923047_ChIP-ChIP_STHdh_Human	1.52682286
35	P300_19829295_ChIP-Seq_ESCs_Human	1.51754476
36	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.50103426
37	SOX2_19829295_ChIP-Seq_ESCs_Human	1.45659842
38	NANOG_19829295_ChIP-Seq_ESCs_Human	1.45659842
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.43563678
40	EWS_26573619_Chip-Seq_HEK293_Human	1.42224459
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.41154134
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39686698
43	TCF4_23295773_ChIP-Seq_U87_Human	1.39271809
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.38684686
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.38515762
46	AR_25329375_ChIP-Seq_VCAP_Human	1.37448484
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35504452
48	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.35166014
49	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.34592893
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33306505
51	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.33252616
52	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.30134250
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.29909860
54	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.28026491
55	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.26958913
56	TAF15_26573619_Chip-Seq_HEK293_Human	1.26717284
57	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.26203568
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.24497110
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.23390540
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22965475
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22936365
62	CDX2_22108803_ChIP-Seq_LS180_Human	1.22816974
63	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21213521
64	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.21047108
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19177387
66	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19173556
67	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17891285
68	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.15792334
69	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.15766825
70	AR_20517297_ChIP-Seq_VCAP_Human	1.14974217
71	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14875047
72	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.14486368
73	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14206464
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.13831137
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12568657
76	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.08749745
77	ERG_20517297_ChIP-Seq_VCAP_Human	1.07520532
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07086965
79	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06300605
80	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05933273
81	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.05361261
82	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.05088385
83	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04332606
84	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03897295
85	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.03619279
86	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.03113491
87	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02947037
88	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02914097
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02415736
90	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.02300091
91	GATA3_26560356_Chip-Seq_TH1_Human	1.01992155
92	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.01577179
93	PHF8_20622853_ChIP-Seq_HELA_Human	1.01510024
94	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.00371296
95	NCOR_22424771_ChIP-Seq_293T_Human	0.99800772
96	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.99307097
97	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.97908557
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97793973
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.97785669
100	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.97588231

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	4.67169153
2	MP0002638_abnormal_pupillary_reflex	4.59539273
3	MP0002822_catalepsy	4.27225922
4	MP0004147_increased_porphyrin_level	4.23456183
5	MP0005083_abnormal_biliary_tract	4.10973233
6	MP0008877_abnormal_DNA_methylation	3.30705776
7	MP0005379_endocrine/exocrine_gland_phen	3.21307664
8	MP0005084_abnormal_gallbladder_morpholo	2.84620703
9	MP0005085_abnormal_gallbladder_physiolo	2.81563927
10	MP0003195_calcinosis	2.69490513
11	MP0005365_abnormal_bile_salt	2.55964542
12	MP0010386_abnormal_urinary_bladder	2.55204406
13	MP0005075_abnormal_melanosome_morpholog	2.26241583
14	MP0008058_abnormal_DNA_repair	2.12650608
15	MP0002928_abnormal_bile_duct	2.08667627
16	MP0002160_abnormal_reproductive_system	2.06715045
17	MP0006072_abnormal_retinal_apoptosis	1.98598029
18	MP0001764_abnormal_homeostasis	1.85318763
19	MP0002163_abnormal_gland_morphology	1.85202666
20	MP0005253_abnormal_eye_physiology	1.82619899
21	MP0002837_dystrophic_cardiac_calcinosis	1.78605669
22	MP0005645_abnormal_hypothalamus_physiol	1.75565524
23	MP0002139_abnormal_hepatobiliary_system	1.72664025
24	MP0008775_abnormal_heart_ventricle	1.69976831
25	MP0005551_abnormal_eye_electrophysiolog	1.69173859
26	MP0000427_abnormal_hair_cycle	1.67881811
27	MP0008057_abnormal_DNA_replication	1.64919407
28	MP0008995_early_reproductive_senescence	1.61158441
29	MP0005332_abnormal_amino_acid	1.58612810
30	MP0002909_abnormal_adrenal_gland	1.56702767
31	MP0002876_abnormal_thyroid_physiology	1.55761473
32	MP0001501_abnormal_sleep_pattern	1.50558136
33	MP0003252_abnormal_bile_duct	1.48546155
34	MP0001986_abnormal_taste_sensitivity	1.43724999
35	MP0003786_premature_aging	1.41450092
36	MP0003943_abnormal_hepatobiliary_system	1.38730637
37	MP0003787_abnormal_imprinting	1.36403840
38	MP0005389_reproductive_system_phenotype	1.33365225
39	MP0002210_abnormal_sex_determination	1.32466850
40	MP0003868_abnormal_feces_composition	1.30992182
41	MP0001929_abnormal_gametogenesis	1.23803194
42	MP0009046_muscle_twitch	1.22985159
43	MP0004043_abnormal_pH_regulation	1.22222540
44	MP0000013_abnormal_adipose_tissue	1.20385282
45	MP0002272_abnormal_nervous_system	1.12231259
46	MP0001145_abnormal_male_reproductive	1.10261127
47	MP0008875_abnormal_xenobiotic_pharmacok	1.06466701
48	MP0005167_abnormal_blood-brain_barrier	1.05810350
49	MP0010678_abnormal_skin_adnexa	1.04832480
50	MP0010094_abnormal_chromosome_stability	1.04540346
51	MP0001835_abnormal_antigen_presentation	1.03948956
52	MP0003880_abnormal_central_pattern	1.03318650
53	MP0000653_abnormal_sex_gland	1.02503869
54	MP0009780_abnormal_chondrocyte_physiolo	1.02368956
55	MP0001502_abnormal_circadian_rhythm	1.01828865
56	MP0001905_abnormal_dopamine_level	1.01362240
57	MP0004145_abnormal_muscle_electrophysio	1.01135114
58	MP0000383_abnormal_hair_follicle	0.97935873
59	MP0008872_abnormal_physiological_respon	0.96841505
60	MP0009745_abnormal_behavioral_response	0.95568867
61	MP0000372_irregular_coat_pigmentation	0.95050132
62	MP0005220_abnormal_exocrine_pancreas	0.95009896
63	MP0003693_abnormal_embryo_hatching	0.94959235
64	MP0005535_abnormal_body_temperature	0.94828366
65	MP0001853_heart_inflammation	0.91155867
66	MP0005636_abnormal_mineral_homeostasis	0.90402919
67	MP0005310_abnormal_salivary_gland	0.89658402
68	MP0003698_abnormal_male_reproductive	0.87625352
69	MP0003718_maternal_effect	0.86755172
70	MP0000538_abnormal_urinary_bladder	0.85230401
71	MP0002693_abnormal_pancreas_physiology	0.81792018
72	MP0002735_abnormal_chemical_nociception	0.80840293
73	MP0001666_abnormal_nutrient_absorption	0.80102234
74	MP0005646_abnormal_pituitary_gland	0.79011540
75	MP0008873_increased_physiological_sensi	0.76314055
76	MP0003183_abnormal_peptide_metabolism	0.74346078
77	MP0010234_abnormal_vibrissa_follicle	0.74097529
78	MP0003123_paternal_imprinting	0.74061728
79	MP0002118_abnormal_lipid_homeostasis	0.73744771
80	MP0005448_abnormal_energy_balance	0.73533644
81	MP0003283_abnormal_digestive_organ	0.73022520
82	MP0002078_abnormal_glucose_homeostasis	0.72650628
83	MP0006082_CNS_inflammation	0.70657459
84	MP0002102_abnormal_ear_morphology	0.70352074
85	MP0004142_abnormal_muscle_tone	0.70024809
86	MP0001944_abnormal_pancreas_morphology	0.67750430
87	MP0005647_abnormal_sex_gland	0.67593130
88	MP0001765_abnormal_ion_homeostasis	0.62861113
89	MP0000230_abnormal_systemic_arterial	0.61419308
90	MP0002229_neurodegeneration	0.60329899
91	MP0002064_seizures	0.59566478
92	MP0003186_abnormal_redox_activity	0.59168094
93	MP0009333_abnormal_splenocyte_physiolog	0.58397789
94	MP0000015_abnormal_ear_pigmentation	0.58106070
95	MP0005386_behavior/neurological_phenoty	0.58063293
96	MP0004924_abnormal_behavior	0.58063293
97	MP0001119_abnormal_female_reproductive	0.57259518
98	MP0010329_abnormal_lipoprotein_level	0.56581855
99	MP0003953_abnormal_hormone_level	0.55649179
100	MP0005376_homeostasis/metabolism_phenot	0.55478970

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal hair whorl (HP:0010721)	4.91376498
2	Azoospermia (HP:0000027)	4.84377502
3	Abnormality of the corticospinal tract (HP:0002492)	4.12852064
4	Methylmalonic acidemia (HP:0002912)	3.78370423
5	Abnormal spermatogenesis (HP:0008669)	3.76601422
6	Hypoglycemic coma (HP:0001325)	3.75276578
7	Abnormality of the renal cortex (HP:0011035)	3.62991919
8	Volvulus (HP:0002580)	3.54457825
9	Methylmalonic aciduria (HP:0012120)	3.50367688
10	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.41381623
11	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.41381623
12	Ketoacidosis (HP:0001993)	3.23981416
13	Patchy hypopigmentation of hair (HP:0011365)	3.22438454
14	Hypoglycemic seizures (HP:0002173)	3.21011748
15	Short tibia (HP:0005736)	3.17180622
16	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.12226260
17	White forelock (HP:0002211)	3.11522755
18	Testicular atrophy (HP:0000029)	3.06250940
19	Pancreatic cysts (HP:0001737)	3.00072874
20	Chronic hepatic failure (HP:0100626)	2.91587365
21	Hyperinsulinemic hypoglycemia (HP:0000825)	2.90539998
22	Nephronophthisis (HP:0000090)	2.83946574
23	Molar tooth sign on MRI (HP:0002419)	2.78368857
24	Abnormality of midbrain morphology (HP:0002418)	2.78368857
25	Hypothermia (HP:0002045)	2.75282717
26	Abnormality of vitamin B metabolism (HP:0004340)	2.69771174
27	Renal cortical cysts (HP:0000803)	2.62502292
28	Progressive inability to walk (HP:0002505)	2.62206236
29	Pancreatic fibrosis (HP:0100732)	2.59609084
30	Ketosis (HP:0001946)	2.56326854
31	Abnormality of the renal medulla (HP:0100957)	2.45707017
32	True hermaphroditism (HP:0010459)	2.44504045
33	Abnormality of the lower motor neuron (HP:0002366)	2.39778507
34	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.36754970
35	Symptomatic seizures (HP:0011145)	2.35199775
36	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.32624858
37	Abnormality of alanine metabolism (HP:0010916)	2.32624858
38	Hyperalaninemia (HP:0003348)	2.32624858
39	Abnormal biliary tract physiology (HP:0012439)	2.32548693
40	Bile duct proliferation (HP:0001408)	2.32548693
41	Fibular hypoplasia (HP:0003038)	2.27151190
42	Amyotrophic lateral sclerosis (HP:0007354)	2.26930466
43	Gonadotropin excess (HP:0000837)	2.25462192
44	Tubular atrophy (HP:0000092)	2.24857396
45	Abolished electroretinogram (ERG) (HP:0000550)	2.22417556
46	Dicarboxylic aciduria (HP:0003215)	2.19024576
47	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.19024576
48	Pili torti (HP:0003777)	2.17054916
49	Progressive macrocephaly (HP:0004481)	2.16343214
50	Abnormal drinking behavior (HP:0030082)	2.14933195
51	Polydipsia (HP:0001959)	2.14933195
52	Abnormality of endocrine pancreas physiology (HP:0012093)	2.12140244
53	Abnormality of the pancreatic islet cells (HP:0006476)	2.12140244
54	Acute necrotizing encephalopathy (HP:0006965)	2.09756465
55	Cutaneous melanoma (HP:0012056)	2.07877857
56	Gaze-evoked nystagmus (HP:0000640)	2.07438422
57	Tachypnea (HP:0002789)	2.06870168
58	Type I transferrin isoform profile (HP:0003642)	2.02935804
59	Hypokinesia (HP:0002375)	2.02488764
60	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.02038918
61	Attenuation of retinal blood vessels (HP:0007843)	2.01726389
62	Absent thumb (HP:0009777)	2.01430215
63	Unilateral renal agenesis (HP:0000122)	2.01226179
64	Metaphyseal dysplasia (HP:0100255)	1.99535659
65	Hepatic necrosis (HP:0002605)	1.99037729
66	Hand muscle atrophy (HP:0009130)	1.98534643
67	Hypoplastic iliac wings (HP:0002866)	1.98507495
68	Cystic liver disease (HP:0006706)	1.97783965
69	Type II lissencephaly (HP:0007260)	1.97254793
70	Upper motor neuron abnormality (HP:0002127)	1.93786990
71	Type I diabetes mellitus (HP:0100651)	1.91817617
72	Abnormality of vitamin metabolism (HP:0100508)	1.91568800
73	Impaired vibration sensation in the lower limbs (HP:0002166)	1.89904300
74	Abnormal protein N-linked glycosylation (HP:0012347)	1.87322424
75	Abnormal protein glycosylation (HP:0012346)	1.87322424
76	Abnormal glycosylation (HP:0012345)	1.87322424
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.87322424
78	Diminished movement (HP:0002374)	1.85619636
79	EEG with generalized epileptiform discharges (HP:0011198)	1.84700142
80	Downturned corners of mouth (HP:0002714)	1.83978281
81	Increased CSF lactate (HP:0002490)	1.82714555
82	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.82529572
83	Hyperglycemia (HP:0003074)	1.82510539
84	Abnormal hair laboratory examination (HP:0003328)	1.80892579
85	Tongue fasciculations (HP:0001308)	1.76462231
86	Abnormality of homocysteine metabolism (HP:0010919)	1.74983821
87	Homocystinuria (HP:0002156)	1.74983821
88	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.74260194
89	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.74260194
90	Epileptiform EEG discharges (HP:0011182)	1.74113295
91	Neoplasm of the thyroid gland (HP:0100031)	1.73850352
92	Acute myeloid leukemia (HP:0004808)	1.73653838
93	Horizontal nystagmus (HP:0000666)	1.73473607
94	Hyperthyroidism (HP:0000836)	1.72593370
95	Acute encephalopathy (HP:0006846)	1.71799120
96	Abnormal mitochondria in muscle tissue (HP:0008316)	1.70665285
97	Inability to walk (HP:0002540)	1.70363228
98	Tetraplegia (HP:0002445)	1.69806368
99	Hypomagnesemia (HP:0002917)	1.69786172
100	Mitochondrial inheritance (HP:0001427)	1.69062343

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.03576009
2	FRK	4.78305204
3	TAOK3	4.64690676
4	NME1	4.16520821
5	BMPR2	3.27655819
6	EIF2AK3	2.74536930
7	STK39	2.60512754
8	WNK4	2.35123940
9	PINK1	1.94730233
10	OXSR1	1.83601256
11	PNCK	1.79568531
12	NUAK1	1.77895728
13	ACVR1B	1.77597066
14	PHKG2	1.71408732
15	PHKG1	1.71408732
16	GRK5	1.69388941
17	NTRK3	1.65327683
18	BMPR1B	1.62555899
19	LIMK1	1.62471661
20	PIK3CG	1.59905231
21	MST4	1.53334172
22	GRK1	1.44980560
23	ERBB3	1.33271014
24	MAP3K2	1.26603732
25	TRPM7	1.23826633
26	TNK2	1.09160343
27	RIPK4	1.08122126
28	MAPK13	1.07334802
29	PTK2B	1.07244890
30	MAPKAPK3	1.03321588
31	CSNK1G3	1.00269569
32	CSNK1G2	0.97883532
33	ADRBK2	0.97383626
34	FGFR2	0.94794530
35	STK3	0.92976074
36	SCYL2	0.89346250
37	MAP3K9	0.89070632
38	MAP2K2	0.88857035
39	TNIK	0.84625707
40	CSNK1G1	0.82388011
41	MKNK2	0.80834325
42	RAF1	0.78991446
43	WNK3	0.78891526
44	PAK3	0.78627189
45	IKBKB	0.74938078
46	BUB1	0.74737663
47	MAP3K4	0.74108314
48	TTK	0.71173366
49	ZAK	0.69666801
50	CCNB1	0.67526822
51	WEE1	0.65590681
52	WNK1	0.64910895
53	MUSK	0.62346275
54	DAPK2	0.61000496
55	EIF2AK1	0.60821341
56	INSRR	0.60539132
57	EIF2AK2	0.59887884
58	MAP3K7	0.58948895
59	IKBKE	0.57703950
60	CAMK1	0.55221370
61	PRKAA1	0.55160266
62	TEC	0.55070933
63	ATR	0.55070350
64	MAP2K1	0.54129546
65	PRKAA2	0.53592181
66	FGFR3	0.53110275
67	ATM	0.51392776
68	RPS6KA4	0.49609475
69	TXK	0.48807529
70	FER	0.47421001
71	PIM1	0.45919775
72	PASK	0.45498176
73	STK38L	0.45424960
74	PRKCE	0.45208379
75	NEK9	0.44815063
76	IRAK2	0.44427274
77	DAPK1	0.43299669
78	GRK6	0.41719503
79	FLT3	0.39835300
80	PRKG1	0.37106041
81	PLK3	0.36485545
82	CSNK1D	0.35681984
83	STK4	0.34999634
84	OBSCN	0.34372889
85	MAP2K6	0.33117966
86	CHEK2	0.31989338
87	CAMK2A	0.31985124
88	CSF1R	0.31512398
89	PRKCG	0.30372619
90	STK16	0.30011828
91	MAP3K14	0.29584543
92	CAMK4	0.29091344
93	PLK1	0.29038304
94	CDK1	0.27109056
95	TGFBR1	0.27084429
96	CSNK1A1	0.26833422
97	PRKCB	0.26803975
98	CDK19	0.26117500
99	MARK3	0.26082508
100	RPS6KB1	0.25897901

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	4.39870927
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.78385642
3	Butanoate metabolism_Homo sapiens_hsa00650	2.50740397
4	Regulation of autophagy_Homo sapiens_hsa04140	2.49690124
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.32906888
6	One carbon pool by folate_Homo sapiens_hsa00670	2.31684736
7	Homologous recombination_Homo sapiens_hsa03440	2.26484732
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.12372286
9	Insulin secretion_Homo sapiens_hsa04911	2.03025607
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.92198868
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.90976336
12	Propanoate metabolism_Homo sapiens_hsa00640	1.89683239
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.86663327
14	RNA degradation_Homo sapiens_hsa03018	1.82126257
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.75553044
16	RNA polymerase_Homo sapiens_hsa03020	1.64758017
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.64230364
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.62237256
19	Retinol metabolism_Homo sapiens_hsa00830	1.55749684
20	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.51412543
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.46484682
22	ABC transporters_Homo sapiens_hsa02010	1.44337159
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.37769227
24	Oxidative phosphorylation_Homo sapiens_hsa00190	1.34704543
25	Folate biosynthesis_Homo sapiens_hsa00790	1.33713046
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.32313576
27	Basal transcription factors_Homo sapiens_hsa03022	1.29673565
28	Phototransduction_Homo sapiens_hsa04744	1.27859013
29	Fatty acid metabolism_Homo sapiens_hsa01212	1.26581076
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.24802204
31	Fatty acid elongation_Homo sapiens_hsa00062	1.21687810
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.20413332
33	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.20090980
34	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.16858833
35	Steroid biosynthesis_Homo sapiens_hsa00100	1.16749609
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15761535
37	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.14082875
38	Parkinsons disease_Homo sapiens_hsa05012	1.12290563
39	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.05077587
40	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.01429502
41	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.97569387
42	Mismatch repair_Homo sapiens_hsa03430	0.93588475
43	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.93067312
44	Olfactory transduction_Homo sapiens_hsa04740	0.91217219
45	RNA transport_Homo sapiens_hsa03013	0.89209233
46	Type I diabetes mellitus_Homo sapiens_hsa04940	0.88346669
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.87886669
48	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.87749746
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87569064
50	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.87307667
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.86659762
52	Amphetamine addiction_Homo sapiens_hsa05031	0.86007462
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85880159
54	Circadian rhythm_Homo sapiens_hsa04710	0.81257464
55	Salivary secretion_Homo sapiens_hsa04970	0.80918557
56	Oocyte meiosis_Homo sapiens_hsa04114	0.80012223
57	Morphine addiction_Homo sapiens_hsa05032	0.79915648
58	Pancreatic secretion_Homo sapiens_hsa04972	0.79679839
59	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.79676069
60	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.78677956
61	mTOR signaling pathway_Homo sapiens_hsa04150	0.78360626
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.77423388
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.77201252
64	Peroxisome_Homo sapiens_hsa04146	0.77175962
65	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.75979233
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.74327997
67	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.74083492
68	Metabolic pathways_Homo sapiens_hsa01100	0.73127507
69	Fatty acid degradation_Homo sapiens_hsa00071	0.67458885
70	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.66836353
71	Sulfur metabolism_Homo sapiens_hsa00920	0.65671228
72	Serotonergic synapse_Homo sapiens_hsa04726	0.65127980
73	Long-term depression_Homo sapiens_hsa04730	0.64969488
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.64146231
75	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.64028702
76	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.63634105
77	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62527451
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.60904723
79	Purine metabolism_Homo sapiens_hsa00230	0.59860848
80	Alzheimers disease_Homo sapiens_hsa05010	0.59653608
81	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.59202270
82	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.58956559
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57215318
84	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.55116492
85	Collecting duct acid secretion_Homo sapiens_hsa04966	0.54672642
86	Renin secretion_Homo sapiens_hsa04924	0.53432432
87	Type II diabetes mellitus_Homo sapiens_hsa04930	0.52522259
88	Nicotine addiction_Homo sapiens_hsa05033	0.51621388
89	Huntingtons disease_Homo sapiens_hsa05016	0.51478459
90	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.51304450
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.51216982
92	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.46597541
93	Glutamatergic synapse_Homo sapiens_hsa04724	0.46434889
94	Base excision repair_Homo sapiens_hsa03410	0.43658746
95	Circadian entrainment_Homo sapiens_hsa04713	0.42233636
96	Taste transduction_Homo sapiens_hsa04742	0.41671053
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41497455
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41264463
99	Mineral absorption_Homo sapiens_hsa04978	0.41204398
100	GABAergic synapse_Homo sapiens_hsa04727	0.39939399

MLLT10P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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