MLLT11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.62259247
2vocalization behavior (GO:0071625)5.61756218
3neuron cell-cell adhesion (GO:0007158)5.58842018
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.38860918
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.35259891
6protein localization to synapse (GO:0035418)5.12978492
7glutamate secretion (GO:0014047)5.00737197
8regulation of glutamate receptor signaling pathway (GO:1900449)4.87756720
9regulation of synaptic vesicle exocytosis (GO:2000300)4.87607317
10establishment of mitochondrion localization (GO:0051654)4.80697834
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.80346920
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.77998608
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.67307559
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.50873943
15synaptic vesicle maturation (GO:0016188)4.50013508
16neurotransmitter-gated ion channel clustering (GO:0072578)4.47631283
17presynaptic membrane assembly (GO:0097105)4.44141804
18postsynaptic membrane organization (GO:0001941)4.40499774
19pyrimidine nucleobase catabolic process (GO:0006208)4.39827386
20locomotory exploration behavior (GO:0035641)4.30226049
21neurotransmitter secretion (GO:0007269)4.29455996
22regulation of synaptic vesicle transport (GO:1902803)4.26800496
23neuron recognition (GO:0008038)4.22217222
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.21205714
25presynaptic membrane organization (GO:0097090)4.17758547
26exploration behavior (GO:0035640)4.07352310
27neuron-neuron synaptic transmission (GO:0007270)4.03663992
28sequestering of actin monomers (GO:0042989)4.01583991
29synaptic transmission, glutamatergic (GO:0035249)3.97204450
30neuronal action potential propagation (GO:0019227)3.92063791
31glutamate receptor signaling pathway (GO:0007215)3.91169537
32layer formation in cerebral cortex (GO:0021819)3.90230140
33positive regulation of synapse maturation (GO:0090129)3.89202744
34negative regulation of synaptic transmission, GABAergic (GO:0032229)3.87772175
35regulation of synapse structural plasticity (GO:0051823)3.87222696
36cell migration in hindbrain (GO:0021535)3.74862724
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.74286203
38axonal fasciculation (GO:0007413)3.73114624
39proline transport (GO:0015824)3.70627890
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.70540809
41nucleobase catabolic process (GO:0046113)3.69124939
42negative regulation of microtubule polymerization (GO:0031115)3.69109498
43positive regulation of mitochondrial fission (GO:0090141)3.68790266
44glycosphingolipid biosynthetic process (GO:0006688)3.59967381
45regulation of neuronal synaptic plasticity (GO:0048168)3.58904154
46behavioral response to nicotine (GO:0035095)3.57828286
47positive regulation of synapse assembly (GO:0051965)3.56119799
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.53912293
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.49591345
50protein localization to cilium (GO:0061512)3.49041425
51neural tube formation (GO:0001841)3.48460821
52neurotransmitter transport (GO:0006836)3.44637847
53gamma-aminobutyric acid transport (GO:0015812)3.44345497
54dendritic spine morphogenesis (GO:0060997)3.42530723
55sympathetic nervous system development (GO:0048485)3.42324940
56negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.41358693
57synaptic vesicle endocytosis (GO:0048488)3.39944771
58regulation of postsynaptic membrane potential (GO:0060078)3.39787869
59hippocampus development (GO:0021766)3.38961516
60regulation of feeding behavior (GO:0060259)3.38069282
61long-term synaptic potentiation (GO:0060291)3.36603478
62positive regulation of membrane potential (GO:0045838)3.36404674
63startle response (GO:0001964)3.34245677
64ATP hydrolysis coupled proton transport (GO:0015991)3.34123135
65energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.34123135
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33685171
67calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.33601007
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.32282975
69retinal ganglion cell axon guidance (GO:0031290)3.31050848
70positive regulation of synaptic transmission, GABAergic (GO:0032230)3.30846243
71synapse assembly (GO:0007416)3.29155017
72regulation of neurotransmitter secretion (GO:0046928)3.28803553
73mitochondrion transport along microtubule (GO:0047497)3.28494266
74establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.28494266
75neurofilament cytoskeleton organization (GO:0060052)3.27068830
76response to histamine (GO:0034776)3.27013963
77cerebellar granule cell differentiation (GO:0021707)3.26858741
78limb bud formation (GO:0060174)3.22041904
79transferrin transport (GO:0033572)3.21853478
80regulation of synapse maturation (GO:0090128)3.20427685
81auditory behavior (GO:0031223)3.18765723
82regulation of neurotransmitter levels (GO:0001505)3.18669082
83positive regulation of neurotransmitter transport (GO:0051590)3.18398597
84negative regulation of dendrite morphogenesis (GO:0050774)3.17991641
85regulation of synaptic plasticity (GO:0048167)3.13706155
86positive regulation of neurotransmitter secretion (GO:0001956)3.13039022
87regulation of vesicle fusion (GO:0031338)3.12035806
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.11797492
89behavioral defense response (GO:0002209)3.11165944
90behavioral fear response (GO:0001662)3.11165944
91dendrite morphogenesis (GO:0048813)3.07641764
92activation of protein kinase A activity (GO:0034199)3.07482425
93long-term memory (GO:0007616)3.07405201
94positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.06859691
95negative regulation of dendrite development (GO:2000171)3.06108360
96regulation of glutamate secretion (GO:0014048)3.05808673
97regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04531116
98dendrite development (GO:0016358)3.03943675
99transmission of nerve impulse (GO:0019226)3.03479052
100mechanosensory behavior (GO:0007638)3.02753439
101positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.02435595
102positive regulation of dendritic spine morphogenesis (GO:0061003)3.02055295
103regulation of neurotransmitter transport (GO:0051588)3.02043571
104regulation of dendritic spine morphogenesis (GO:0061001)3.01137863
105establishment of synaptic vesicle localization (GO:0097480)2.99308191
106synaptic vesicle transport (GO:0048489)2.99308191
107cerebellar Purkinje cell differentiation (GO:0021702)2.99012933
108learning (GO:0007612)2.98949349
109substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.98891431
110substrate-independent telencephalic tangential migration (GO:0021826)2.98891431
111head development (GO:0060322)2.98520188
112regulation of synapse assembly (GO:0051963)2.98262797
113glial cell proliferation (GO:0014009)2.98154966
114neuronal ion channel clustering (GO:0045161)2.97074463
115ferric iron transport (GO:0015682)2.96940966
116trivalent inorganic cation transport (GO:0072512)2.96940966
117organelle transport along microtubule (GO:0072384)2.95977703
118fear response (GO:0042596)2.94988643
119membrane depolarization (GO:0051899)2.94589424
120response to auditory stimulus (GO:0010996)2.93617859
121synaptic transmission (GO:0007268)2.93245202
122central nervous system projection neuron axonogenesis (GO:0021952)2.93005194
123regulation of synaptic transmission, GABAergic (GO:0032228)2.92659634
124central nervous system neuron axonogenesis (GO:0021955)2.87271661
125synapse organization (GO:0050808)2.85974823
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.84613229
127epithelial cell differentiation involved in kidney development (GO:0035850)2.84467961
128neuromuscular synaptic transmission (GO:0007274)2.82802826
129nonmotile primary cilium assembly (GO:0035058)2.80348098
130olfactory bulb development (GO:0021772)2.78584339
131positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.77737691
132mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.77737691
133negative regulation of oligodendrocyte differentiation (GO:0048715)2.76659352
134behavioral response to ethanol (GO:0048149)2.75488968
135cerebral cortex radially oriented cell migration (GO:0021799)2.75178883
136positive regulation of amino acid transport (GO:0051957)2.74208850
137protein polyglutamylation (GO:0018095)2.73666350
138short-term memory (GO:0007614)2.73537286
139ribonucleoprotein complex disassembly (GO:0032988)2.72503771
140cytoskeleton-dependent intracellular transport (GO:0030705)2.72145596
141regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.71387771
142DNA damage response, detection of DNA damage (GO:0042769)2.68293791
143protein insertion into membrane (GO:0051205)2.67779477
144forebrain neuron differentiation (GO:0021879)2.67461501
145establishment of vesicle localization (GO:0051650)2.67046426
146cardiac ventricle formation (GO:0003211)2.64563225
147ganglion development (GO:0061548)2.64484914
148protein-cofactor linkage (GO:0018065)2.63093259
149spinal cord development (GO:0021510)2.60642179
150axonogenesis (GO:0007409)2.59723922
151axon extension (GO:0048675)2.59091122
152neuronal action potential (GO:0019228)2.59005095
153cullin deneddylation (GO:0010388)2.58276630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.99095757
2GBX2_23144817_ChIP-Seq_PC3_Human4.25016324
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09174610
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95276029
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85976213
6REST_21632747_ChIP-Seq_MESCs_Mouse2.79874407
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.78079894
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.61541475
9TAF15_26573619_Chip-Seq_HEK293_Human2.56386608
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51401121
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48596385
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48105787
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46692878
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46692878
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42885094
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40908688
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34773412
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31630854
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.29428209
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25034375
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.19013048
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.12755973
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.11763030
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11613846
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09381545
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.08729369
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07945503
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03910512
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.02566546
30AR_21572438_ChIP-Seq_LNCaP_Human1.94357882
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93904908
32DROSHA_22980978_ChIP-Seq_HELA_Human1.84769879
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84408465
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83530933
35SMAD4_21799915_ChIP-Seq_A2780_Human1.75808527
36EWS_26573619_Chip-Seq_HEK293_Human1.74985300
37P300_19829295_ChIP-Seq_ESCs_Human1.74706965
38* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72021448
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.70856386
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65003028
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63023531
42ZNF274_21170338_ChIP-Seq_K562_Hela1.61926162
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.61504626
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59086551
45RNF2_27304074_Chip-Seq_NSC_Mouse1.58388584
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57107492
47IGF1R_20145208_ChIP-Seq_DFB_Human1.55972403
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51073662
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44343562
50FUS_26573619_Chip-Seq_HEK293_Human1.44304661
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44301258
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42697629
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42053843
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.41964594
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41005649
56AR_25329375_ChIP-Seq_VCAP_Human1.39947468
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38961232
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38950277
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.37966311
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37441890
61VDR_22108803_ChIP-Seq_LS180_Human1.37165735
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31438638
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31238279
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.30285999
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24347402
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22879264
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.21994483
68ER_23166858_ChIP-Seq_MCF-7_Human1.21151930
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18913467
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18073718
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17672239
72STAT3_23295773_ChIP-Seq_U87_Human1.17540144
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16542378
74JUN_21703547_ChIP-Seq_K562_Human1.16440619
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16379162
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16003489
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.15996058
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15075698
79TP53_22573176_ChIP-Seq_HFKS_Human1.13494809
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12156104
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.12069648
82IRF1_19129219_ChIP-ChIP_H3396_Human1.11466151
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.10685988
84TCF4_23295773_ChIP-Seq_U87_Human1.10110114
85TAL1_26923725_Chip-Seq_HPCs_Mouse1.10076759
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09344167
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.09314248
88RUNX2_22187159_ChIP-Seq_PCA_Human1.08296327
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07221036
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06106183
91AR_19668381_ChIP-Seq_PC3_Human1.05518381
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05517858
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04749851
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03907580
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03907580
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03832784
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.03693518
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01953636
99AHR_22903824_ChIP-Seq_MCF-7_Human1.01253543
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00743377
101SOX2_16153702_ChIP-ChIP_HESCs_Human0.99743622
102GABP_17652178_ChIP-ChIP_JURKAT_Human0.98101477
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97380465
104RING1B_27294783_Chip-Seq_NPCs_Mouse0.97016175
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96282621
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95181460
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95137973
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95017917
109NANOG_18555785_Chip-Seq_ESCs_Mouse0.94969186
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94897415
111PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93905664
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.93730979
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93253108
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92946048
115ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92724636
116BCAT_22108803_ChIP-Seq_LS180_Human0.92081357
117KDM2B_26808549_Chip-Seq_REH_Human0.91815607
118GATA1_26923725_Chip-Seq_HPCs_Mouse0.91218236
119SOX9_26525672_Chip-Seq_HEART_Mouse0.90451895
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89354104
121CBP_20019798_ChIP-Seq_JUKART_Human0.89354104
122CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87758972
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87533534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.28572670
2MP0003880_abnormal_central_pattern4.92406409
3MP0003635_abnormal_synaptic_transmissio3.87829638
4MP0004270_analgesia3.67587803
5MP0001968_abnormal_touch/_nociception3.27856974
6MP0002063_abnormal_learning/memory/cond3.27660740
7MP0009745_abnormal_behavioral_response3.25710870
8MP0009046_muscle_twitch3.01218520
9MP0002064_seizures3.00870596
10MP0002734_abnormal_mechanical_nocicepti2.87489172
11MP0002572_abnormal_emotion/affect_behav2.84525998
12MP0002735_abnormal_chemical_nociception2.84204468
13MP0002736_abnormal_nociception_after2.77178332
14MP0005423_abnormal_somatic_nervous2.66613162
15MP0006276_abnormal_autonomic_nervous2.63861743
16MP0002272_abnormal_nervous_system2.40983857
17MP0001440_abnormal_grooming_behavior2.31184941
18MP0001486_abnormal_startle_reflex2.31133762
19MP0000778_abnormal_nervous_system2.30986690
20MP0002733_abnormal_thermal_nociception2.28547606
21MP0002184_abnormal_innervation2.12071862
22MP0001970_abnormal_pain_threshold2.10665439
23MP0002067_abnormal_sensory_capabilities2.09067540
24MP0001529_abnormal_vocalization2.05207708
25MP0002822_catalepsy2.05202267
26MP0001501_abnormal_sleep_pattern1.98090338
27MP0003787_abnormal_imprinting1.92049428
28MP0003122_maternal_imprinting1.91916834
29MP0005386_behavior/neurological_phenoty1.87049412
30MP0004924_abnormal_behavior1.87049412
31MP0002557_abnormal_social/conspecific_i1.85594510
32MP0009780_abnormal_chondrocyte_physiolo1.81366223
33MP0004811_abnormal_neuron_physiology1.81168967
34MP0001984_abnormal_olfaction1.79118580
35MP0005645_abnormal_hypothalamus_physiol1.67005081
36MP0005646_abnormal_pituitary_gland1.63599947
37MP0004858_abnormal_nervous_system1.63083052
38MP0001905_abnormal_dopamine_level1.59610150
39MP0003879_abnormal_hair_cell1.58199915
40MP0000955_abnormal_spinal_cord1.57164523
41MP0001188_hyperpigmentation1.55577907
42MP0008569_lethality_at_weaning1.49381012
43MP0000049_abnormal_middle_ear1.46871675
44MP0004142_abnormal_muscle_tone1.46161851
45MP0002882_abnormal_neuron_morphology1.45854633
46MP0003329_amyloid_beta_deposits1.44869891
47MP0002066_abnormal_motor_capabilities/c1.40756239
48MP0003221_abnormal_cardiomyocyte_apopto1.37959862
49MP0002909_abnormal_adrenal_gland1.34107399
50MP0004133_heterotaxia1.33727896
51MP0000751_myopathy1.31251078
52MP0002837_dystrophic_cardiac_calcinosis1.29525192
53MP0008995_early_reproductive_senescence1.23351881
54MP0002234_abnormal_pharynx_morphology1.21994438
55MP0003890_abnormal_embryonic-extraembry1.19686357
56MP0002152_abnormal_brain_morphology1.16398830
57MP0005253_abnormal_eye_physiology1.16381175
58MP0001502_abnormal_circadian_rhythm1.15982338
59MP0002876_abnormal_thyroid_physiology1.11735999
60MP0003119_abnormal_digestive_system1.06804534
61MP0005394_taste/olfaction_phenotype1.05919591
62MP0005499_abnormal_olfactory_system1.05919591
63MP0006072_abnormal_retinal_apoptosis1.04155151
64MP0010386_abnormal_urinary_bladder1.01910703
65MP0003938_abnormal_ear_development1.01124490
66MP0004885_abnormal_endolymph1.00813807
67MP0000631_abnormal_neuroendocrine_gland0.97515987
68MP0003633_abnormal_nervous_system0.96173208
69MP0002069_abnormal_eating/drinking_beha0.95597285
70MP0006292_abnormal_olfactory_placode0.94858316
71MP0003011_delayed_dark_adaptation0.94307940
72MP0004742_abnormal_vestibular_system0.93962902
73MP0001963_abnormal_hearing_physiology0.90869484
74MP0002233_abnormal_nose_morphology0.90180991
75MP0000569_abnormal_digit_pigmentation0.89960811
76MP0002752_abnormal_somatic_nervous0.89647042
77MP0003631_nervous_system_phenotype0.88560054
78MP0002229_neurodegeneration0.88292008
79MP0005084_abnormal_gallbladder_morpholo0.86777623
80MP0004085_abnormal_heartbeat0.84155496
81MP0000647_abnormal_sebaceous_gland0.82280958
82MP0003121_genomic_imprinting0.81856900
83MP0002751_abnormal_autonomic_nervous0.80999937
84MP0008872_abnormal_physiological_respon0.80917530
85MP0001485_abnormal_pinna_reflex0.80566152
86MP0003646_muscle_fatigue0.79432529
87MP0005551_abnormal_eye_electrophysiolog0.78622821
88MP0000013_abnormal_adipose_tissue0.78440134
89MP0004145_abnormal_muscle_electrophysio0.78160895
90MP0002638_abnormal_pupillary_reflex0.77800759
91MP0005195_abnormal_posterior_eye0.75910088
92MP0003755_abnormal_palate_morphology0.75440308
93MP0001986_abnormal_taste_sensitivity0.74509209
94MP0000516_abnormal_urinary_system0.72080556
95MP0005367_renal/urinary_system_phenotyp0.72080556
96MP0001664_abnormal_digestion0.71931786
97MP0005535_abnormal_body_temperature0.70820604
98MP0003861_abnormal_nervous_system0.70541619
99MP0003567_abnormal_fetal_cardiomyocyte0.70500014
100MP0004233_abnormal_muscle_weight0.70022187
101MP0003385_abnormal_body_wall0.69982505
102MP0003634_abnormal_glial_cell0.69970627
103MP0002081_perinatal_lethality0.67757522
104MP0008874_decreased_physiological_sensi0.67627879
105MP0008789_abnormal_olfactory_epithelium0.67627685
106MP0002102_abnormal_ear_morphology0.67423382
107MP0004484_altered_response_of0.66732530
108MP0000026_abnormal_inner_ear0.66388926
109MP0004215_abnormal_myocardial_fiber0.66112713
110MP0003937_abnormal_limbs/digits/tail_de0.65137461
111MP0001943_abnormal_respiration0.62662535
112MP0001177_atelectasis0.61661746
113MP0008877_abnormal_DNA_methylation0.61419980
114MP0003632_abnormal_nervous_system0.60036112
115MP0002653_abnormal_ependyma_morphology0.59703759
116MP0003183_abnormal_peptide_metabolism0.58741785
117MP0003137_abnormal_impulse_conducting0.58030459
118MP0006035_abnormal_mitochondrial_morpho0.57661738
119MP0002082_postnatal_lethality0.57065862
120MP0010770_preweaning_lethality0.57065862
121MP0010769_abnormal_survival0.54739024
122MP0005187_abnormal_penis_morphology0.52943693
123MP0000604_amyloidosis0.52341854
124MP0010768_mortality/aging0.51724287

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.01408776
2Myokymia (HP:0002411)5.61889296
3Epileptic encephalopathy (HP:0200134)5.11944930
4Focal seizures (HP:0007359)5.10878882
5Atonic seizures (HP:0010819)4.95433026
6Visual hallucinations (HP:0002367)4.57820400
7Febrile seizures (HP:0002373)4.43320823
8Hyperventilation (HP:0002883)4.28663050
9Absence seizures (HP:0002121)4.00472243
10Progressive cerebellar ataxia (HP:0002073)3.94120206
11Cortical dysplasia (HP:0002539)3.66615958
12Dialeptic seizures (HP:0011146)3.66405447
13Polyphagia (HP:0002591)3.66330372
14Broad-based gait (HP:0002136)3.59354012
15Limb dystonia (HP:0002451)3.46321247
16Retinal dysplasia (HP:0007973)3.45008741
17Generalized tonic-clonic seizures (HP:0002069)3.44539568
18Abnormal hair whorl (HP:0010721)3.25175702
19Amblyopia (HP:0000646)3.21269735
20Pheochromocytoma (HP:0002666)3.19688779
21Abnormal eating behavior (HP:0100738)3.19271239
22Pachygyria (HP:0001302)3.08574319
23Progressive inability to walk (HP:0002505)3.04530173
24Drooling (HP:0002307)3.02933957
25Excessive salivation (HP:0003781)3.02933957
26Impaired vibration sensation in the lower limbs (HP:0002166)2.99552038
27Gait imbalance (HP:0002141)2.98133310
28Failure to thrive in infancy (HP:0001531)2.95064212
29Mutism (HP:0002300)2.92355229
30Neuroendocrine neoplasm (HP:0100634)2.92336434
31Ankle clonus (HP:0011448)2.91123218
32Epileptiform EEG discharges (HP:0011182)2.87024395
33Poor eye contact (HP:0000817)2.83837372
34Poor suck (HP:0002033)2.80536751
35Supranuclear gaze palsy (HP:0000605)2.79144250
36EEG with generalized epileptiform discharges (HP:0011198)2.69922509
37Inability to walk (HP:0002540)2.67996345
38Truncal ataxia (HP:0002078)2.67956633
39Split foot (HP:0001839)2.64868321
40Termporal pattern (HP:0011008)2.64450361
41Insidious onset (HP:0003587)2.64450361
42Genital tract atresia (HP:0001827)2.64330721
43Fetal akinesia sequence (HP:0001989)2.63123007
44Abnormality of the corticospinal tract (HP:0002492)2.62807880
45Gaze-evoked nystagmus (HP:0000640)2.62318525
46Spastic tetraplegia (HP:0002510)2.61558895
47Amyotrophic lateral sclerosis (HP:0007354)2.60922427
48Vaginal atresia (HP:0000148)2.59808160
49Hypsarrhythmia (HP:0002521)2.58938060
50Abnormal social behavior (HP:0012433)2.56931451
51Impaired social interactions (HP:0000735)2.56931451
52Urinary bladder sphincter dysfunction (HP:0002839)2.53114999
53Anxiety (HP:0000739)2.51942356
54Akinesia (HP:0002304)2.51768434
55Action tremor (HP:0002345)2.51341913
56Urinary urgency (HP:0000012)2.48344556
57Depression (HP:0000716)2.44953675
58Hypoplasia of the brainstem (HP:0002365)2.43833773
59Aplasia/Hypoplasia of the brainstem (HP:0007362)2.43833773
60Abnormality of the labia minora (HP:0012880)2.41729512
61Dysdiadochokinesis (HP:0002075)2.41134378
62Acute necrotizing encephalopathy (HP:0006965)2.40386331
63Pancreatic cysts (HP:0001737)2.36152321
64Specific learning disability (HP:0001328)2.35760390
65Protruding tongue (HP:0010808)2.34220685
66Medial flaring of the eyebrow (HP:0010747)2.32902322
67Hypothermia (HP:0002045)2.31942652
68Abnormality of binocular vision (HP:0011514)2.30609662
69Diplopia (HP:0000651)2.30609662
70Congenital primary aphakia (HP:0007707)2.29747146
71Abnormality of midbrain morphology (HP:0002418)2.29298371
72Molar tooth sign on MRI (HP:0002419)2.29298371
73Degeneration of the lateral corticospinal tracts (HP:0002314)2.28846625
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.28846625
75Abnormal mitochondria in muscle tissue (HP:0008316)2.28160691
76Oligomenorrhea (HP:0000876)2.25703167
77Spastic gait (HP:0002064)2.24462876
78Pancreatic fibrosis (HP:0100732)2.24145067
79Sleep apnea (HP:0010535)2.23431518
80Progressive macrocephaly (HP:0004481)2.22962967
81Nephronophthisis (HP:0000090)2.22269649
82True hermaphroditism (HP:0010459)2.22059291
83Absent speech (HP:0001344)2.21243978
84Hypoventilation (HP:0002791)2.21003352
85Genetic anticipation (HP:0003743)2.19701792
86Polymicrogyria (HP:0002126)2.18762910
87Abnormality of the lower motor neuron (HP:0002366)2.18409721
88Atrophy/Degeneration involving motor neurons (HP:0007373)2.17977542
89Esotropia (HP:0000565)2.17575234
90Nephrogenic diabetes insipidus (HP:0009806)2.16893938
91Pendular nystagmus (HP:0012043)2.14761940
92Dysmetria (HP:0001310)2.13759425
93Torticollis (HP:0000473)2.13416047
94Lissencephaly (HP:0001339)2.12457920
95Type II lissencephaly (HP:0007260)2.11104464
96Hepatoblastoma (HP:0002884)2.08937128
97Abnormality of the hip-girdle musculature (HP:0001445)2.07890218
98Abnormality of the musculature of the pelvis (HP:0001469)2.07890218
99Focal dystonia (HP:0004373)2.07775228
100Poor coordination (HP:0002370)2.06616205
101Muscular hypotonia of the trunk (HP:0008936)2.05814472
102Shoulder girdle muscle weakness (HP:0003547)2.05781045
103Cerebral inclusion bodies (HP:0100314)2.05513079
104Agitation (HP:0000713)2.05498819
105Hyperthyroidism (HP:0000836)2.05419300
106Exotropia (HP:0000577)2.04316709
107Intestinal atresia (HP:0011100)2.03736127
108Bradykinesia (HP:0002067)2.02843507
109Thyroid-stimulating hormone excess (HP:0002925)2.02708856
110Narrow nasal bridge (HP:0000446)2.00116891
111Abnormality of salivation (HP:0100755)1.97533634
112Lower limb muscle weakness (HP:0007340)1.96866796
113Hemiparesis (HP:0001269)1.96677270
114Generalized hypotonia (HP:0001290)1.96002481
115Stereotypic behavior (HP:0000733)1.95518974
116Hypoplasia of the corpus callosum (HP:0002079)1.95262662
117Delusions (HP:0000746)1.94599579
118Blue irides (HP:0000635)1.93559046
119Neoplasm of the peripheral nervous system (HP:0100007)1.92948389
120Scanning speech (HP:0002168)1.92601068
121Morphological abnormality of the pyramidal tract (HP:0002062)1.92196692
122Increased serum pyruvate (HP:0003542)1.91580329
123Abnormality of glycolysis (HP:0004366)1.91580329
124Peripheral hypomyelination (HP:0007182)1.91438899
125Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89830694
126Abnormality of pain sensation (HP:0010832)1.89313630
127Impaired pain sensation (HP:0007328)1.89313630
128Patellar aplasia (HP:0006443)1.89221624
129Papilledema (HP:0001085)1.88622411
130Ulnar claw (HP:0001178)1.88308823
131Impaired vibratory sensation (HP:0002495)1.88237228
132Impaired smooth pursuit (HP:0007772)1.88187055
133Craniofacial dystonia (HP:0012179)1.87796100
134Generalized myoclonic seizures (HP:0002123)1.86866336
135Narrow forehead (HP:0000341)1.85412011
136Postaxial hand polydactyly (HP:0001162)1.84684890
137Decreased testicular size (HP:0008734)1.84360660
138Methylmalonic acidemia (HP:0002912)1.83377498
139Renal cortical cysts (HP:0000803)1.82212061
140Rimmed vacuoles (HP:0003805)1.80874472
141Optic nerve hypoplasia (HP:0000609)1.78614218
142Aplasia/Hypoplasia of the patella (HP:0006498)1.76943776
143Micropenis (HP:0000054)1.76929837
144Chronic hepatic failure (HP:0100626)1.76401922
145Abnormality of the renal medulla (HP:0100957)1.76036311
146Scrotal hypoplasia (HP:0000046)1.74426401
147Labial hypoplasia (HP:0000066)1.74236053

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.67221965
2CASK4.53358516
3NTRK33.50614486
4MAP3K123.41732116
5MAP3K43.27236861
6MAP2K73.16319020
7TRIM283.10502694
8MAP3K92.94204116
9MAP4K22.75838116
10EPHA42.73004522
11MINK12.72829671
12DAPK22.15118785
13NTRK22.07701293
14CDK192.07195709
15PLK22.05491086
16MAPK132.04146241
17MAP2K42.02839598
18DAPK11.79068289
19PINK11.74412852
20CSNK1G11.67203708
21KSR11.66629336
22GRK51.60014412
23DYRK31.58485942
24SIK31.52963154
25PAK61.50565230
26EPHA31.45109531
27PRPF4B1.43304060
28SRPK11.42460629
29PNCK1.34564183
30CDK51.34063887
31PHKG11.33671564
32PHKG21.33671564
33DYRK21.30147350
34TNIK1.27297902
35CCNB11.25134575
36NME11.23722716
37PRKCG1.20790488
38SIK21.17464885
39ARAF1.13855180
40AKT31.11444986
41UHMK11.10385875
42OXSR11.08212829
43KSR21.07327135
44BCR1.05180213
45RPS6KA41.04281450
46DYRK1B1.04227975
47FRK1.04152704
48LATS21.00683736
49CDK180.99740315
50CAMK2A0.98983682
51NTRK10.98660190
52CAMKK10.96770686
53CDK140.95413104
54RIPK40.94957495
55ERBB30.94820950
56LIMK10.93780739
57CSNK1G20.91803719
58CDK150.90248444
59SGK4940.87030284
60SGK2230.87030284
61CAMKK20.85354889
62DYRK1A0.84004098
63PDK30.83726108
64PDK40.83726108
65BCKDK0.82012095
66SGK20.80112488
67CAMK2B0.79858865
68TSSK60.79102588
69CDK11A0.78017626
70WNK30.76718262
71GRK10.70109637
72TESK10.67478632
73FES0.66748017
74PRKCE0.66070951
75PAK30.63763970
76PTK2B0.63505548
77MAP3K50.63140843
78GRK70.62947296
79MAP3K60.59649443
80INSRR0.58819927
81RPS6KA20.58465722
82BRAF0.56452081
83STK110.55586899
84ADRBK10.55267800
85TYRO30.54640677
86CSNK1G30.53972784
87BMPR1B0.52325955
88PRKD30.50689178
89BMPR20.50622084
90PRKCZ0.50479600
91MARK20.50278303
92RET0.50100853
93MAP3K20.48366449
94FGR0.47477569
95SGK10.47114045
96ADRBK20.45249762
97MAPK120.44525122
98PRKACA0.44398133
99CSNK1D0.44130968
100EPHB20.44054773
101CSNK1A10.42985146
102SGK30.42429196
103DAPK30.42321755
104CAMK10.41834920
105TESK20.40813228
106RAF10.39956686
107MAP2K10.39933249
108CSNK1E0.39333501
109PKN10.39023747
110TAOK10.39016554
111RPS6KA50.38903323
112STK380.38376128
113FER0.38062923
114PRKACB0.37730802
115STK38L0.37472800
116PRKAA10.37414522
117NEK10.37288867
118CAMK2D0.36021053
119CAMK2G0.35837728
120PRKG10.34768592
121MAPK90.34373432
122PRKCH0.32773408
123ROCK20.30353050
124MYLK0.30011721
125CAMK40.29882387
126FYN0.29433214
127RPS6KA30.29273844
128CSNK1A1L0.29208531
129VRK10.25864650
130PRKACG0.23870184
131WNK40.23863863
132MAPK40.22867974
133PRKCB0.22438701
134CDK30.22220512
135MAPK80.21887365
136ZAK0.21141941

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.02770748
2Synaptic vesicle cycle_Homo sapiens_hsa047213.98834787
3Collecting duct acid secretion_Homo sapiens_hsa049662.81165961
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74179479
5GABAergic synapse_Homo sapiens_hsa047272.63522678
6Olfactory transduction_Homo sapiens_hsa047402.49227309
7Circadian entrainment_Homo sapiens_hsa047132.47631076
8Morphine addiction_Homo sapiens_hsa050322.44007082
9Long-term potentiation_Homo sapiens_hsa047202.38329497
10Glutamatergic synapse_Homo sapiens_hsa047242.29859220
11Amphetamine addiction_Homo sapiens_hsa050312.26475886
12Dopaminergic synapse_Homo sapiens_hsa047282.23415393
13Protein export_Homo sapiens_hsa030601.98757788
14Oxidative phosphorylation_Homo sapiens_hsa001901.92967319
15Taste transduction_Homo sapiens_hsa047421.90865514
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88383824
17Serotonergic synapse_Homo sapiens_hsa047261.82901373
18Vibrio cholerae infection_Homo sapiens_hsa051101.82715746
19Steroid biosynthesis_Homo sapiens_hsa001001.80071788
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79856592
21Cholinergic synapse_Homo sapiens_hsa047251.76515117
22Salivary secretion_Homo sapiens_hsa049701.75487302
23Insulin secretion_Homo sapiens_hsa049111.74419624
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71845643
25Long-term depression_Homo sapiens_hsa047301.65922287
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.65411025
27Renin secretion_Homo sapiens_hsa049241.61341131
28Cocaine addiction_Homo sapiens_hsa050301.57100529
29Gastric acid secretion_Homo sapiens_hsa049711.49882715
30Parkinsons disease_Homo sapiens_hsa050121.49386616
31Axon guidance_Homo sapiens_hsa043601.44302300
32Oxytocin signaling pathway_Homo sapiens_hsa049211.42778021
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41696659
34Alzheimers disease_Homo sapiens_hsa050101.41092724
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40143131
36Calcium signaling pathway_Homo sapiens_hsa040201.38547127
37Basal transcription factors_Homo sapiens_hsa030221.38152946
38Gap junction_Homo sapiens_hsa045401.36767222
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36063650
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.35978973
41Cardiac muscle contraction_Homo sapiens_hsa042601.30099974
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26718270
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25185752
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21501472
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19647650
46GnRH signaling pathway_Homo sapiens_hsa049121.16653311
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14442993
48Huntingtons disease_Homo sapiens_hsa050161.05009415
49ErbB signaling pathway_Homo sapiens_hsa040121.03317499
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02463094
51Phototransduction_Homo sapiens_hsa047441.02202841
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01978339
53cAMP signaling pathway_Homo sapiens_hsa040240.98092699
54Estrogen signaling pathway_Homo sapiens_hsa049150.94823627
55Glioma_Homo sapiens_hsa052140.88509044
56Ether lipid metabolism_Homo sapiens_hsa005650.87127213
57Melanogenesis_Homo sapiens_hsa049160.86881067
58Type II diabetes mellitus_Homo sapiens_hsa049300.85009861
59Oocyte meiosis_Homo sapiens_hsa041140.82967746
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82586376
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81158297
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79104112
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77911440
64Phagosome_Homo sapiens_hsa041450.73821168
65Propanoate metabolism_Homo sapiens_hsa006400.73619877
66Rheumatoid arthritis_Homo sapiens_hsa053230.71985702
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71235504
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.68290563
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65027756
70MAPK signaling pathway_Homo sapiens_hsa040100.64164551
71Type I diabetes mellitus_Homo sapiens_hsa049400.60549732
72Alcoholism_Homo sapiens_hsa050340.59943898
73Linoleic acid metabolism_Homo sapiens_hsa005910.59247428
74beta-Alanine metabolism_Homo sapiens_hsa004100.59209521
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58634948
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58155807
77Peroxisome_Homo sapiens_hsa041460.57449080
78Ras signaling pathway_Homo sapiens_hsa040140.56218873
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54961132
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53780934
81Dilated cardiomyopathy_Homo sapiens_hsa054140.53497455
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.53142362
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52134026
84Selenocompound metabolism_Homo sapiens_hsa004500.52021417
85Endometrial cancer_Homo sapiens_hsa052130.51755307
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51747095
87Fatty acid elongation_Homo sapiens_hsa000620.51588550
88Glucagon signaling pathway_Homo sapiens_hsa049220.50729921
89Hedgehog signaling pathway_Homo sapiens_hsa043400.50525397
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50146030
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49771248
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49124005
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48800318
94RNA degradation_Homo sapiens_hsa030180.48751458
95Butanoate metabolism_Homo sapiens_hsa006500.48167365
96mRNA surveillance pathway_Homo sapiens_hsa030150.47743541
97Colorectal cancer_Homo sapiens_hsa052100.46896551
98Hippo signaling pathway_Homo sapiens_hsa043900.46392547
99RNA polymerase_Homo sapiens_hsa030200.45427255
100Renal cell carcinoma_Homo sapiens_hsa052110.44546486
101Choline metabolism in cancer_Homo sapiens_hsa052310.43868535
102Pancreatic secretion_Homo sapiens_hsa049720.42346336
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42313551
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.41956618
105Thyroid hormone synthesis_Homo sapiens_hsa049180.41938473
106Insulin signaling pathway_Homo sapiens_hsa049100.40640905
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39923601
108Salmonella infection_Homo sapiens_hsa051320.39635706
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38661126
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38454086
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38020774
112Dorso-ventral axis formation_Homo sapiens_hsa043200.37101901
113Rap1 signaling pathway_Homo sapiens_hsa040150.37015637
114Wnt signaling pathway_Homo sapiens_hsa043100.36945617
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36713121
116AMPK signaling pathway_Homo sapiens_hsa041520.36433318
117VEGF signaling pathway_Homo sapiens_hsa043700.36247697
118Tryptophan metabolism_Homo sapiens_hsa003800.35441090
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35389411
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.34935136
121Regulation of autophagy_Homo sapiens_hsa041400.34372350
122Endocytosis_Homo sapiens_hsa041440.33470940
123Pyruvate metabolism_Homo sapiens_hsa006200.32765894
124Metabolic pathways_Homo sapiens_hsa011000.32603975
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30988770
126Circadian rhythm_Homo sapiens_hsa047100.30776765
127Melanoma_Homo sapiens_hsa052180.30516195
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29965398
129Fanconi anemia pathway_Homo sapiens_hsa034600.29509249
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28709744
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28236238
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27510207
133Inositol phosphate metabolism_Homo sapiens_hsa005620.26737176
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25492510
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23380803
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.21512766
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.17657626

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