MLLT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.36781682
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.95133853
3definitive hemopoiesis (GO:0060216)4.78887947
4positive regulation of cardiac muscle cell differentiation (GO:2000727)4.13463544
5cranial nerve morphogenesis (GO:0021602)3.97460140
6protein polyglutamylation (GO:0018095)3.62761681
7positive regulation of granulocyte differentiation (GO:0030854)3.57834315
8presynaptic membrane organization (GO:0097090)3.56719378
9dentate gyrus development (GO:0021542)3.56469108
10sulfation (GO:0051923)3.50968165
11gamma-aminobutyric acid transport (GO:0015812)3.48251315
12limb bud formation (GO:0060174)3.47645824
13mitotic sister chromatid cohesion (GO:0007064)3.43395594
14indolalkylamine metabolic process (GO:0006586)3.40802103
15water-soluble vitamin biosynthetic process (GO:0042364)3.39005210
16presynaptic membrane assembly (GO:0097105)3.38370518
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37972483
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.37972483
19NADH dehydrogenase complex assembly (GO:0010257)3.37972483
20membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.34058962
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33574653
22magnesium ion transport (GO:0015693)3.28580264
23ribosomal small subunit assembly (GO:0000028)3.26759806
24pyrimidine nucleobase catabolic process (GO:0006208)3.23560501
25DNA deamination (GO:0045006)3.23159456
26platelet dense granule organization (GO:0060155)3.21257050
27negative regulation of alpha-beta T cell differentiation (GO:0046639)3.20040382
28negative regulation of erythrocyte differentiation (GO:0045647)3.18881061
29CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.18377488
30retinal ganglion cell axon guidance (GO:0031290)3.14705731
31negative regulation of transcription regulatory region DNA binding (GO:2000678)3.12584375
32serotonin metabolic process (GO:0042428)3.11797973
33L-fucose catabolic process (GO:0042355)3.10543766
34fucose catabolic process (GO:0019317)3.10543766
35L-fucose metabolic process (GO:0042354)3.10543766
36regulation of skeletal muscle contraction (GO:0014819)3.08286692
37histone H3-K4 trimethylation (GO:0080182)3.08046041
38megakaryocyte development (GO:0035855)3.07747666
39spinal cord development (GO:0021510)3.07028920
40embryonic hemopoiesis (GO:0035162)3.05086030
41protein complex biogenesis (GO:0070271)3.04275579
42regulation of membrane repolarization (GO:0060306)3.03904847
43positive regulation of potassium ion transmembrane transport (GO:1901381)3.03557930
44detection of light stimulus involved in sensory perception (GO:0050962)3.02469680
45detection of light stimulus involved in visual perception (GO:0050908)3.02469680
46membrane repolarization during action potential (GO:0086011)3.00940132
47otic vesicle formation (GO:0030916)2.98838754
48establishment of protein localization to mitochondrial membrane (GO:0090151)2.97285951
49regulation of meiosis I (GO:0060631)2.96551056
50kidney morphogenesis (GO:0060993)2.95257158
51ovulation cycle (GO:0042698)2.93840745
52adaptation of signaling pathway (GO:0023058)2.92623247
53lymphoid progenitor cell differentiation (GO:0002320)2.91422601
54DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.90647125
55neuronal action potential (GO:0019228)2.89389962
56primary amino compound metabolic process (GO:1901160)2.89207491
57preassembly of GPI anchor in ER membrane (GO:0016254)2.87441445
58microtubule depolymerization (GO:0007019)2.85935545
59meiotic chromosome segregation (GO:0045132)2.84073694
60positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.83894457
61facial nerve structural organization (GO:0021612)2.83421761
62negative regulation of response to food (GO:0032096)2.82526215
63negative regulation of appetite (GO:0032099)2.82526215
64sister chromatid cohesion (GO:0007062)2.80207577
65negative regulation of systemic arterial blood pressure (GO:0003085)2.79299900
66myoblast migration (GO:0051451)2.79241571
67kinetochore organization (GO:0051383)2.77138337
68membrane depolarization during action potential (GO:0086010)2.75728141
69DNA damage response, signal transduction resulting in transcription (GO:0042772)2.75548509
70transmission of nerve impulse (GO:0019226)2.75466245
71response to pheromone (GO:0019236)2.75131695
72neural tube formation (GO:0001841)2.74279937
73positive regulation of gamma-delta T cell activation (GO:0046645)2.73971156
74cornea development in camera-type eye (GO:0061303)2.72277139
75regulation of mesoderm development (GO:2000380)2.72120163
76regulation of action potential (GO:0098900)2.71837625
77indole-containing compound metabolic process (GO:0042430)2.70152013
78head development (GO:0060322)2.68685675
79T cell lineage commitment (GO:0002360)2.67753882
80regulation of collateral sprouting (GO:0048670)2.67688148
81positive regulation of protein homodimerization activity (GO:0090073)2.66055790
82mitochondrial respiratory chain complex assembly (GO:0033108)2.66016171
83indolalkylamine catabolic process (GO:0046218)2.65754569
84tryptophan catabolic process (GO:0006569)2.65754569
85indole-containing compound catabolic process (GO:0042436)2.65754569
86parturition (GO:0007567)2.65373562
87regulation of rhodopsin mediated signaling pathway (GO:0022400)2.64064928
88negative regulation of astrocyte differentiation (GO:0048712)2.62321423
89kinetochore assembly (GO:0051382)2.61017209
90lung secretory cell differentiation (GO:0061140)2.59612204
91nucleobase catabolic process (GO:0046113)2.59146531
92replication fork processing (GO:0031297)2.58266242
93behavioral response to ethanol (GO:0048149)2.58175738
94regulation of regulatory T cell differentiation (GO:0045589)2.58006279
95cellular response to ATP (GO:0071318)2.57613186
96action potential (GO:0001508)2.56166518
97regulation of DNA endoreduplication (GO:0032875)2.56097241
98G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56054618
99regulation of histone H3-K27 methylation (GO:0061085)2.55233161
100dendritic spine morphogenesis (GO:0060997)2.55225236
101tryptophan metabolic process (GO:0006568)2.54766743
102regulation of germinal center formation (GO:0002634)2.54104693
103prostate gland growth (GO:0060736)2.53326555
104nucleosome disassembly (GO:0006337)2.53153863
105protein-DNA complex disassembly (GO:0032986)2.53153863
106positive regulation of meiosis (GO:0045836)2.53023918
107negative T cell selection (GO:0043383)2.52647224
108negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.52542574
109negative regulation of T-helper cell differentiation (GO:0045623)2.52542574
110hindbrain development (GO:0030902)2.52137905
111regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.51880203
112endoderm formation (GO:0001706)2.50640491
113negative thymic T cell selection (GO:0045060)2.50515588
114rhodopsin mediated signaling pathway (GO:0016056)2.47216479
115cardiovascular system development (GO:0072358)2.47147894
116interkinetic nuclear migration (GO:0022027)2.46695805
117epithelial cilium movement (GO:0003351)2.46686861
118negative regulation of mast cell activation (GO:0033004)2.45893307
119negative regulation of cytosolic calcium ion concentration (GO:0051481)2.44438279
120postsynaptic membrane organization (GO:0001941)2.44087761
121viral transcription (GO:0019083)2.43828466
122negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.42878485
123positive regulation of action potential (GO:0045760)2.42658163
124aggressive behavior (GO:0002118)2.41688162
125axoneme assembly (GO:0035082)2.41242060
126centriole replication (GO:0007099)2.39426367
127positive regulation of fatty acid transport (GO:2000193)2.38852108
128generation of neurons (GO:0048699)2.38753484
129regulation of potassium ion transmembrane transport (GO:1901379)2.37872342
130maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.37736653
131pharyngeal system development (GO:0060037)2.37600021
132DNA methylation involved in gamete generation (GO:0043046)2.36609905
133positive regulation of meiotic cell cycle (GO:0051446)2.36075893
134positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.35980083
135spinal cord motor neuron differentiation (GO:0021522)2.35934149
136cellular response to exogenous dsRNA (GO:0071360)2.35747990
137multicellular organismal signaling (GO:0035637)2.35280236
138peptidyl-lysine trimethylation (GO:0018023)2.34937305
139negative regulation of axon guidance (GO:1902668)2.33836669
140nonmotile primary cilium assembly (GO:0035058)2.33706689
141translational termination (GO:0006415)2.31811607
142central nervous system projection neuron axonogenesis (GO:0021952)2.31635187
143histone H3-K4 methylation (GO:0051568)2.31557702
144somite development (GO:0061053)2.28575970
145thyroid gland development (GO:0030878)2.25693966
146RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.25558022
147secretory granule organization (GO:0033363)2.25418740
148negative regulation of alpha-beta T cell activation (GO:0046636)2.24976529
149adult feeding behavior (GO:0008343)2.23475046
150mRNA splice site selection (GO:0006376)2.21939549
151T cell homeostasis (GO:0043029)2.21892567
152cranial nerve structural organization (GO:0021604)2.21123964
153positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.20223732
154exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.20088199
155negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.19549525
156erythrocyte maturation (GO:0043249)2.18291372
157cerebral cortex radially oriented cell migration (GO:0021799)2.16127382
158T cell differentiation (GO:0030217)2.12905188
159centriole assembly (GO:0098534)2.11625280
160nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.10543854
161regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.09616711
162artery development (GO:0060840)2.09553799
163regulation of mesenchymal cell apoptotic process (GO:2001053)2.08335698
164granulocyte differentiation (GO:0030851)2.08131229
165nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.07629142
166embryonic forelimb morphogenesis (GO:0035115)2.07459852
167histone lysine demethylation (GO:0070076)2.07178824
168intraciliary transport (GO:0042073)2.04245572
169protoporphyrinogen IX metabolic process (GO:0046501)2.04113658
170negative regulation of cell aging (GO:0090344)2.04011614
171peptidyl-arginine methylation (GO:0018216)2.03323782
172peptidyl-arginine N-methylation (GO:0035246)2.03323782
173negative regulation of smooth muscle cell differentiation (GO:0051151)2.02824669
174dosage compensation (GO:0007549)2.02127877
175lymph node development (GO:0048535)2.01811150
176regulation of transcription from RNA polymerase I promoter (GO:0006356)2.00417295
177metaphase plate congression (GO:0051310)2.00188294
178regulation of meiosis (GO:0040020)1.99630148
179DNA synthesis involved in DNA repair (GO:0000731)1.99508379
180DNA damage response, detection of DNA damage (GO:0042769)1.99378977
181regulation of gamma-delta T cell differentiation (GO:0045586)1.97706029
182monoubiquitinated protein deubiquitination (GO:0035520)1.97499611
183cellular response to interleukin-15 (GO:0071350)1.97483353
184erythrocyte development (GO:0048821)1.97431914
185regulation of isotype switching to IgG isotypes (GO:0048302)1.97143762
186positive regulation of mitotic metaphase/anaphase transition (GO:0045842)1.96862564
187positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)1.96862564
188positive regulation of mitotic sister chromatid separation (GO:1901970)1.96862564
189myeloid cell development (GO:0061515)1.96625585
190cell proliferation in forebrain (GO:0021846)1.96414761
191histone demethylation (GO:0016577)1.95557924
192histone mRNA metabolic process (GO:0008334)1.95394131
193regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)1.95234369

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.35630880
2TP63_19390658_ChIP-ChIP_HaCaT_Human4.09897804
3EZH2_22144423_ChIP-Seq_EOC_Human3.63421684
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.46882250
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.38034187
6SCL_19346495_ChIP-Seq_HPC-7_Human3.29601698
7IGF1R_20145208_ChIP-Seq_DFB_Human3.16359949
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.89949419
9VDR_22108803_ChIP-Seq_LS180_Human2.49812092
10GBX2_23144817_ChIP-Seq_PC3_Human2.47401843
11* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43075081
12TAF15_26573619_Chip-Seq_HEK293_Human2.38743887
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.38699452
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35325362
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29368328
16FUS_26573619_Chip-Seq_HEK293_Human2.19453513
17* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06927490
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03142497
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02722500
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01309625
21RNF2_27304074_Chip-Seq_NSC_Mouse1.99863879
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98821579
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.96785690
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.95042066
25* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82945281
26EWS_26573619_Chip-Seq_HEK293_Human1.79105063
27* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72102044
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.69951119
29ER_23166858_ChIP-Seq_MCF-7_Human1.67129579
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.62482151
31* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62398733
32* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61891826
33* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.61700593
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61614954
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61400584
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.58771810
37REST_21632747_ChIP-Seq_MESCs_Mouse1.57454198
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53251027
39* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51738282
40* P300_19829295_ChIP-Seq_ESCs_Human1.51129102
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50024646
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49331081
43E2F7_22180533_ChIP-Seq_HELA_Human1.46708102
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45866658
45* EZH2_27304074_Chip-Seq_ESCs_Mouse1.43434123
46* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42474050
47* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41913152
48STAT3_23295773_ChIP-Seq_U87_Human1.41536352
49BCAT_22108803_ChIP-Seq_LS180_Human1.40624642
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40258073
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.40227233
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40128468
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40128468
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38083184
55TCF4_23295773_ChIP-Seq_U87_Human1.37803562
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35273250
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34460568
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32530957
59CBP_20019798_ChIP-Seq_JUKART_Human1.32530957
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32462770
61ZNF274_21170338_ChIP-Seq_K562_Hela1.31554901
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31453376
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30662886
64RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30065467
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29544475
66* EZH2_27294783_Chip-Seq_ESCs_Mouse1.26436916
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24758808
68* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22409183
69* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20826476
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20508003
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20460185
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20420553
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19637636
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.16302836
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15629641
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15070724
77AR_21572438_ChIP-Seq_LNCaP_Human1.14528213
78TCF4_22108803_ChIP-Seq_LS180_Human1.12592162
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.12501051
80* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12222404
81* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12222404
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12016811
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10617420
84TP53_22573176_ChIP-Seq_HFKS_Human1.10538991
85* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08982999
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08612108
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06087375
88P53_22387025_ChIP-Seq_ESCs_Mouse1.05634210
89NANOG_19829295_ChIP-Seq_ESCs_Human1.05454759
90SOX2_19829295_ChIP-Seq_ESCs_Human1.05454759
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.03946532
92* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03619386
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03551015
94JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03075488
95* RUNX2_22187159_ChIP-Seq_PCA_Human1.01841109
96REST_18959480_ChIP-ChIP_MESCs_Mouse1.01540116
97LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01179085
98* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01176474
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.00764221
100* RNF2_27304074_Chip-Seq_ESCs_Mouse1.00121021
101* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99703241
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99673055
103* SMAD4_21799915_ChIP-Seq_A2780_Human0.98960244
104HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98718259
105E2F1_18555785_Chip-Seq_ESCs_Mouse0.97779242
106ESR1_20079471_ChIP-ChIP_T-47D_Human0.97493245
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97228817
108AR_25329375_ChIP-Seq_VCAP_Human0.96863011
109ELK1_19687146_ChIP-ChIP_HELA_Human0.96710476
110* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96209274
111* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95100345
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95026365
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.93579152
114KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92643157
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92127032
116* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91948260
117YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90957321
118MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90782232
119TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90700102
120SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90637711
121YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90258020
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89649566
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88408527
124* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88210824
125MYC_18940864_ChIP-ChIP_HL60_Human0.88178226
126PRDM14_20953172_ChIP-Seq_ESCs_Human0.87545642
127* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86935619
128KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86668414
129TCF4_18268006_ChIP-ChIP_LS174T_Human0.86570371
130TAL1_26923725_Chip-Seq_HPCs_Mouse0.86406025
131GATA2_21666600_ChIP-Seq_HMVEC_Human0.86098862
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.85832155
133SMAD3_21741376_ChIP-Seq_EPCs_Human0.85166459
134EZH2_27294783_Chip-Seq_NPCs_Mouse0.84681828
135* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.84247900
136IRF1_19129219_ChIP-ChIP_H3396_Human0.84180579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.00350255
2MP0002837_dystrophic_cardiac_calcinosis3.29818712
3MP0003121_genomic_imprinting2.88198868
4MP0004147_increased_porphyrin_level2.65709382
5MP0001968_abnormal_touch/_nociception2.64985047
6MP0003787_abnormal_imprinting2.64034190
7MP0002102_abnormal_ear_morphology2.63851751
8MP0002736_abnormal_nociception_after2.36078617
9MP0004885_abnormal_endolymph2.34183434
10MP0004145_abnormal_muscle_electrophysio2.26623060
11MP0002160_abnormal_reproductive_system2.23980531
12MP0003880_abnormal_central_pattern2.21260678
13MP0004808_abnormal_hematopoietic_stem2.18582541
14MP0009697_abnormal_copulation2.16946639
15MP0003122_maternal_imprinting2.10277061
16MP0003315_abnormal_perineum_morphology2.07999138
17MP0002009_preneoplasia2.03053736
18MP0002249_abnormal_larynx_morphology1.96837478
19MP0005551_abnormal_eye_electrophysiolog1.93544804
20MP0000569_abnormal_digit_pigmentation1.93066741
21MP0006072_abnormal_retinal_apoptosis1.89307594
22MP0002272_abnormal_nervous_system1.83403336
23MP0002735_abnormal_chemical_nociception1.79770143
24MP0000566_synostosis1.75335867
25MP0009745_abnormal_behavioral_response1.71571562
26MP0004142_abnormal_muscle_tone1.71231996
27MP0005389_reproductive_system_phenotype1.71145263
28MP0003763_abnormal_thymus_physiology1.67972139
29MP0003123_paternal_imprinting1.65237744
30MP0003635_abnormal_synaptic_transmissio1.58121167
31MP0008775_abnormal_heart_ventricle1.56463756
32MP0010030_abnormal_orbit_morphology1.53925725
33MP0002234_abnormal_pharynx_morphology1.53137004
34MP0008872_abnormal_physiological_respon1.52782886
35MP0009250_abnormal_appendicular_skeleto1.50524346
36MP0008877_abnormal_DNA_methylation1.49926900
37MP0002938_white_spotting1.49661264
38MP0006276_abnormal_autonomic_nervous1.48320218
39MP0005174_abnormal_tail_pigmentation1.47100222
40MP0005409_darkened_coat_color1.44995748
41MP0002733_abnormal_thermal_nociception1.43367686
42MP0002572_abnormal_emotion/affect_behav1.42693945
43MP0004130_abnormal_muscle_cell1.42199196
44MP0002063_abnormal_learning/memory/cond1.41851584
45MP0002396_abnormal_hematopoietic_system1.41249087
46MP0002095_abnormal_skin_pigmentation1.37851896
47MP0001188_hyperpigmentation1.37818621
48MP0000631_abnormal_neuroendocrine_gland1.37344336
49MP0003011_delayed_dark_adaptation1.37048962
50MP0009046_muscle_twitch1.36861165
51MP0008789_abnormal_olfactory_epithelium1.34980162
52MP0001440_abnormal_grooming_behavior1.33800255
53MP0005253_abnormal_eye_physiology1.33648205
54MP0002653_abnormal_ependyma_morphology1.33558583
55MP0000049_abnormal_middle_ear1.32286563
56MP0000778_abnormal_nervous_system1.31438937
57MP0003283_abnormal_digestive_organ1.31281981
58MP0003937_abnormal_limbs/digits/tail_de1.31087366
59MP0001486_abnormal_startle_reflex1.31019337
60MP0001970_abnormal_pain_threshold1.27948647
61MP0001485_abnormal_pinna_reflex1.27799874
62MP0005423_abnormal_somatic_nervous1.27468078
63MP0004510_myositis1.27177982
64MP0002177_abnormal_outer_ear1.26650746
65MP0002064_seizures1.25463143
66MP0003656_abnormal_erythrocyte_physiolo1.24469225
67MP0000015_abnormal_ear_pigmentation1.23146439
68MP0004742_abnormal_vestibular_system1.20206620
69MP0002163_abnormal_gland_morphology1.19456144
70MP0009379_abnormal_foot_pigmentation1.19415149
71MP0005084_abnormal_gallbladder_morpholo1.17713144
72MP0002067_abnormal_sensory_capabilities1.17027418
73MP0000465_gastrointestinal_hemorrhage1.15232929
74MP0001919_abnormal_reproductive_system1.14428227
75MP0010094_abnormal_chromosome_stability1.14310303
76MP0004924_abnormal_behavior1.13437780
77MP0005386_behavior/neurological_phenoty1.13437780
78MP0002734_abnormal_mechanical_nocicepti1.13340909
79MP0008058_abnormal_DNA_repair1.12991379
80MP0003385_abnormal_body_wall1.12812848
81MP0008995_early_reproductive_senescence1.10544762
82MP0005367_renal/urinary_system_phenotyp1.08934070
83MP0000516_abnormal_urinary_system1.08934070
84MP0001529_abnormal_vocalization1.08160725
85MP0002138_abnormal_hepatobiliary_system1.07315557
86MP0001986_abnormal_taste_sensitivity1.07234720
87MP0003646_muscle_fatigue1.07079710
88MP0001984_abnormal_olfaction1.06325601
89MP0004133_heterotaxia1.06061532
90MP0000955_abnormal_spinal_cord1.05706194
91MP0003938_abnormal_ear_development1.05221215
92MP0003567_abnormal_fetal_cardiomyocyte1.04464284
93MP0005187_abnormal_penis_morphology1.03438683
94MP0003119_abnormal_digestive_system1.03294260
95MP0000749_muscle_degeneration1.02906836
96MP0002752_abnormal_somatic_nervous1.02652932
97MP0000372_irregular_coat_pigmentation1.02615571
98MP0003943_abnormal_hepatobiliary_system1.02446048
99MP0000427_abnormal_hair_cycle1.02062822
100MP0000383_abnormal_hair_follicle1.01547910
101MP0000490_abnormal_crypts_of0.99285044
102MP0002233_abnormal_nose_morphology0.98852035
103MP0004215_abnormal_myocardial_fiber0.98443303
104MP0002876_abnormal_thyroid_physiology0.98243609
105MP0002116_abnormal_craniofacial_bone0.97954001
106MP0005645_abnormal_hypothalamus_physiol0.97867305
107MP0000026_abnormal_inner_ear0.97347862
108MP0001545_abnormal_hematopoietic_system0.96548041
109MP0005397_hematopoietic_system_phenotyp0.96548041
110MP0000230_abnormal_systemic_arterial0.95531056
111MP0000613_abnormal_salivary_gland0.95492336
112MP0002166_altered_tumor_susceptibility0.94972976
113MP0001119_abnormal_female_reproductive0.94847964
114MP0008007_abnormal_cellular_replicative0.93830622
115MP0002398_abnormal_bone_marrow0.93560558
116MP0005379_endocrine/exocrine_gland_phen0.93131681
117MP0005671_abnormal_response_to0.92991588
118* MP0002932_abnormal_joint_morphology0.92954122
119MP0001963_abnormal_hearing_physiology0.92645438
120MP0003077_abnormal_cell_cycle0.92535926
121MP0003718_maternal_effect0.92457466
122MP0005195_abnormal_posterior_eye0.91768818
123MP0000703_abnormal_thymus_morphology0.91081912
124MP0010368_abnormal_lymphatic_system0.90932861
125MP0002184_abnormal_innervation0.90773611
126MP0003935_abnormal_craniofacial_develop0.88691290
127MP0002006_tumorigenesis0.87689111
128MP0002882_abnormal_neuron_morphology0.87597864
129MP0000537_abnormal_urethra_morphology0.87386890
130MP0003755_abnormal_palate_morphology0.85350616
131MP0001501_abnormal_sleep_pattern0.85228277
132MP0002106_abnormal_muscle_physiology0.83953844
133MP0005499_abnormal_olfactory_system0.83870292
134MP0005394_taste/olfaction_phenotype0.83870292
135MP0003942_abnormal_urinary_system0.83841121
136* MP0002114_abnormal_axial_skeleton0.83466786
137MP0004085_abnormal_heartbeat0.82383885
138MP0005646_abnormal_pituitary_gland0.80209932
139MP0004134_abnormal_chest_morphology0.80123851
140MP0002229_neurodegeneration0.77093973
141MP0002822_catalepsy0.76330776
142MP0002751_abnormal_autonomic_nervous0.76274255
143MP0002109_abnormal_limb_morphology0.75692824
144MP0003861_abnormal_nervous_system0.74245059
145MP0002210_abnormal_sex_determination0.73152661
146MP0002638_abnormal_pupillary_reflex0.71681584
147MP0001293_anophthalmia0.70778596
148MP0008057_abnormal_DNA_replication0.70313752
149MP0000681_abnormal_thyroid_gland0.68818145
150MP0000432_abnormal_head_morphology0.68444108
151MP0000733_abnormal_muscle_development0.67725832
152MP0002282_abnormal_trachea_morphology0.67370896
153MP0005369_muscle_phenotype0.67223779
154MP0002557_abnormal_social/conspecific_i0.65289670
155MP0004484_altered_response_of0.64144719
156MP0001905_abnormal_dopamine_level0.64020258
157* MP0002081_perinatal_lethality0.63139069
158MP0004859_abnormal_synaptic_plasticity0.60257619
159MP0003693_abnormal_embryo_hatching0.59827273
160MP0009053_abnormal_anal_canal0.59277182
161MP0004270_analgesia0.59270024
162MP0005075_abnormal_melanosome_morpholog0.59123611

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)4.41125347
2Pancreatic fibrosis (HP:0100732)3.86131702
3Nephronophthisis (HP:0000090)3.68952731
4Congenital stationary night blindness (HP:0007642)3.57749178
5Hyperventilation (HP:0002883)3.32172192
6Abnormality of midbrain morphology (HP:0002418)3.29681116
7Molar tooth sign on MRI (HP:0002419)3.29681116
8Volvulus (HP:0002580)3.26974316
9Abnormality of the renal medulla (HP:0100957)3.10499986
10Abnormality of the fingertips (HP:0001211)3.10324868
11Nonprogressive disorder (HP:0003680)3.01549539
12Facial hemangioma (HP:0000329)2.97310972
13Pendular nystagmus (HP:0012043)2.86552795
14Abnormality of the proximal phalanges of the hand (HP:0009834)2.77935832
15Progressive cerebellar ataxia (HP:0002073)2.74784120
16Type 2 muscle fiber atrophy (HP:0003554)2.74371810
17Abnormality of the phalanges of the 2nd finger (HP:0009541)2.72126698
18Abnormality of the renal cortex (HP:0011035)2.67873811
19Type II lissencephaly (HP:0007260)2.64241801
20Abolished electroretinogram (ERG) (HP:0000550)2.62041786
21Gaze-evoked nystagmus (HP:0000640)2.61919391
22Short 4th metacarpal (HP:0010044)2.55612606
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.55612606
24Lip pit (HP:0100267)2.55467764
25Muscle fiber atrophy (HP:0100295)2.53957967
26Genetic anticipation (HP:0003743)2.53903313
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.51426821
28Cystic liver disease (HP:0006706)2.51062385
29Abnormal hair whorl (HP:0010721)2.49872028
30Small hand (HP:0200055)2.48816649
31Asplenia (HP:0001746)2.45117947
32Birth length less than 3rd percentile (HP:0003561)2.42809226
33Syringomyelia (HP:0003396)2.42217140
34Spinal cord lesions (HP:0100561)2.42217140
35Methylmalonic acidemia (HP:0002912)2.41381175
36Abnormal rod and cone electroretinograms (HP:0008323)2.41352428
37Asymmetry of the thorax (HP:0001555)2.40868732
38Capillary hemangiomas (HP:0005306)2.40664609
39Aplasia/Hypoplasia of the spleen (HP:0010451)2.39802852
40Abnormality of the phalanges of the hallux (HP:0010057)2.39239161
41Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.34995183
42Short 1st metacarpal (HP:0010034)2.34995183
43Acute myeloid leukemia (HP:0004808)2.33003805
44Abnormality of the parietal bone (HP:0002696)2.30573043
45Symphalangism affecting the phalanges of the hand (HP:0009773)2.28520468
46Broad-based gait (HP:0002136)2.26841530
47Fatigue (HP:0012378)2.26771002
48Furrowed tongue (HP:0000221)2.26539405
49Thrombocytosis (HP:0001894)2.26298722
50Short middle phalanx of the 5th finger (HP:0004220)2.25344395
51Aplasia/Hypoplasia of the tibia (HP:0005772)2.24288686
52Abnormality of the middle phalanges of the toes (HP:0010183)2.23219293
53Attenuation of retinal blood vessels (HP:0007843)2.20712646
54Chronic hepatic failure (HP:0100626)2.19124902
55Focal motor seizures (HP:0011153)2.18111046
56Amaurosis fugax (HP:0100576)2.17933218
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.16684319
58Absent/shortened dynein arms (HP:0200106)2.16684319
59Decreased circulating renin level (HP:0003351)2.16590471
60Renal cortical cysts (HP:0000803)2.16333950
61Myelodysplasia (HP:0002863)2.15669413
62Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.13671425
63Prolonged bleeding time (HP:0003010)2.13591882
64Chorioretinal atrophy (HP:0000533)2.13116118
65Decreased central vision (HP:0007663)2.12887060
66Abnormality of the musculature of the pelvis (HP:0001469)2.09989105
67Abnormality of the hip-girdle musculature (HP:0001445)2.09989105
68Increased corneal curvature (HP:0100692)2.09586226
69Keratoconus (HP:0000563)2.09586226
70Fair hair (HP:0002286)2.08986243
71Acute lymphatic leukemia (HP:0006721)2.08460229
72Sclerocornea (HP:0000647)2.07243545
73Pachygyria (HP:0001302)2.06154439
74Abnormality of the 1st metacarpal (HP:0010009)2.05171855
75Midline defect of the nose (HP:0004122)2.04209262
76Bulbous nose (HP:0000414)2.03515461
77Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.03487042
78Adactyly (HP:0009776)2.03057886
79Patellar aplasia (HP:0006443)2.02407253
80Aplasia/Hypoplasia of the hallux (HP:0008362)2.02017592
81Methylmalonic aciduria (HP:0012120)2.01984308
82Stomach cancer (HP:0012126)2.01212279
83Postaxial foot polydactyly (HP:0001830)2.00230335
84Abnormality of DNA repair (HP:0003254)2.00226821
85Short hallux (HP:0010109)1.99431131
86Congenital hepatic fibrosis (HP:0002612)1.99319190
87Aplasia/Hypoplasia of the uvula (HP:0010293)1.98789723
88Oligodontia (HP:0000677)1.98342364
89Anencephaly (HP:0002323)1.97941843
90Drooling (HP:0002307)1.97869819
91Abnormal drinking behavior (HP:0030082)1.96119888
92Polydipsia (HP:0001959)1.96119888
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95845388
94Long eyelashes (HP:0000527)1.95224860
95Lissencephaly (HP:0001339)1.94262731
96Congenital, generalized hypertrichosis (HP:0004540)1.93632517
97Protruding tongue (HP:0010808)1.92414719
98Aplasia/Hypoplasia of the patella (HP:0006498)1.92177803
99Weak cry (HP:0001612)1.91549737
100Narrow nasal bridge (HP:0000446)1.90218454
101Megalencephaly (HP:0001355)1.89777596
102Papillary thyroid carcinoma (HP:0002895)1.88565404
103Optic nerve hypoplasia (HP:0000609)1.87688427
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87444997
105Short tibia (HP:0005736)1.86075302
106Abnormality of chromosome segregation (HP:0002916)1.85815391
107Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.85385830
108Abnormality of the columella (HP:0009929)1.85338300
109Absent speech (HP:0001344)1.84625392
110Chromsome breakage (HP:0040012)1.84551611
111Hypoplasia of the uterus (HP:0000013)1.83912672
112Abnormality of the labia minora (HP:0012880)1.83562997
113Focal seizures (HP:0007359)1.83080004
114Aplasia/Hypoplasia of the tongue (HP:0010295)1.81469164
115Nephrogenic diabetes insipidus (HP:0009806)1.81093012
116Postaxial hand polydactyly (HP:0001162)1.80704360
117Male pseudohermaphroditism (HP:0000037)1.80360265
118Hypothermia (HP:0002045)1.80072407
119Abnormality of the phalanges of the 5th finger (HP:0004213)1.79969703
120Bony spicule pigmentary retinopathy (HP:0007737)1.79510344
121Tubular atrophy (HP:0000092)1.79432000
122Clubbing of toes (HP:0100760)1.79421605
123Morphological abnormality of the middle ear (HP:0008609)1.79244195
124Abnormality of the nasal septum (HP:0000419)1.79172997
125Aplasia/hypoplasia of the uterus (HP:0008684)1.77951351
126Fatigable weakness (HP:0003473)1.77760704
127Abnormality of the neuromuscular junction (HP:0003398)1.77760704
128Excessive salivation (HP:0003781)1.77271499
129Inability to walk (HP:0002540)1.77159052
130Short femoral neck (HP:0100864)1.76814508
131Genital tract atresia (HP:0001827)1.75550123
132Tented upper lip vermilion (HP:0010804)1.74677352
133Abnormal number of incisors (HP:0011064)1.74666961
134Hemiparesis (HP:0001269)1.73688633
135Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.73638221
136Abnormality of the preputium (HP:0100587)1.70983594
137Abnormality of the intervertebral disk (HP:0005108)1.70690004
138Generalized hypopigmentation of hair (HP:0011358)1.70008662
139Gait imbalance (HP:0002141)1.69832254
140Supernumerary spleens (HP:0009799)1.68564539
141Aplasia/Hypoplasia of the sternum (HP:0006714)1.68520558
142Increased number of teeth (HP:0011069)1.67020970
143Abnormality of the 4th metacarpal (HP:0010012)1.66899119
144Meckel diverticulum (HP:0002245)1.66758722
145Febrile seizures (HP:0002373)1.64992970
146Duodenal stenosis (HP:0100867)1.64769382
147Small intestinal stenosis (HP:0012848)1.64769382
148Muscle fiber inclusion bodies (HP:0100299)1.64764492
149Abnormality of cells of the erythroid lineage (HP:0012130)1.63721155
150Abnormality of the ileum (HP:0001549)1.62968630
151Ectopic kidney (HP:0000086)1.62763487
152Growth hormone deficiency (HP:0000824)1.62190119
153Thyroiditis (HP:0100646)1.62118872
154Renal hypoplasia (HP:0000089)1.60653931
155Abnormal number of erythroid precursors (HP:0012131)1.60548132
156Long clavicles (HP:0000890)1.60371464
157Hypoplastic labia majora (HP:0000059)1.59051973
158True hermaphroditism (HP:0010459)1.58787442
159Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.58698169
160Chromosomal breakage induced by crosslinking agents (HP:0003221)1.57907464
161Abnormality of the labia majora (HP:0012881)1.55236928
162Medial flaring of the eyebrow (HP:0010747)1.54881911
163IgM deficiency (HP:0002850)1.54550508
164Abnormality of the carotid arteries (HP:0005344)1.54513605
165Nemaline bodies (HP:0003798)1.54390734
166Abnormality of chromosome stability (HP:0003220)1.52473427
167Oligodactyly (HP:0012165)1.52206329
168Triphalangeal thumb (HP:0001199)1.51337033
169Congenital primary aphakia (HP:0007707)1.50445045
170Thyroid carcinoma (HP:0002890)1.50242625
171Abnormality of hair growth rate (HP:0011363)1.49159035
172Slow-growing hair (HP:0002217)1.49159035
173Tinnitus (HP:0000360)1.49082049
174Dental malocclusion (HP:0000689)1.48999498
175Fibular aplasia (HP:0002990)1.47817372
176Pancreatic cysts (HP:0001737)1.47057351
177Microglossia (HP:0000171)1.45214364
178Arterial thrombosis (HP:0004420)1.44802072
179Aplastic anemia (HP:0001915)1.43608874
180Abnormality of the incisor (HP:0000676)1.43454701
181Inappropriate behavior (HP:0000719)1.41943809
182Mesomelia (HP:0003027)1.41479280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK4.94505145
2MAP4K23.24948052
3TLK13.14186339
4MKNK12.95047240
5MKNK22.66577532
6CDK82.46486590
7TXK2.45347900
8MAP3K122.42685924
9ADRBK22.35600601
10TNIK2.35275756
11CDC72.19284554
12TGFBR12.16004950
13PINK12.08644846
14MAPK132.04107121
15WNK31.97536600
16SRPK11.89098938
17MAP3K61.84538016
18KSR11.78638673
19EEF2K1.73861787
20MARK11.69028435
21MAP2K71.67698407
22DYRK31.65074996
23CDK191.64099426
24CDK91.58735520
25CASK1.58697513
26ZAK1.57287380
27EPHB21.56739362
28DYRK21.56063667
29AKT31.51315157
30TIE11.49562187
31EPHA41.49206573
32LATS11.43096275
33NUAK11.32432277
34PHKG11.32181643
35PLK41.28498893
36INSRR1.27476516
37CHEK21.24813525
38JAK31.23980475
39SIK31.22521216
40VRK11.22376090
41CAMKK21.18383931
42OBSCN1.16911489
43MAP4K11.16516107
44LATS21.07496739
45ACVR1B1.06657695
46BCKDK1.06481951
47CSNK1G11.06074004
48PRKD21.04740749
49EPHA31.04626868
50PIK3CA1.04405050
51WNK41.03857419
52MAPKAPK31.03483738
53CDK31.03459241
54SGK4941.03410050
55SGK2231.03410050
56PLK21.00840371
57NEK60.97587800
58FRK0.92491608
59HIPK20.91245045
60BMPR1B0.91198555
61CSNK1G30.90085152
62SIK20.89524439
63MAP2K60.88898721
64STK240.88319481
65PRKCG0.85506987
66DAPK20.85191565
67GRK50.84010661
68ADRBK10.83988515
69MAP3K40.83785614
70BTK0.83278670
71TGFBR20.83094739
72PAK30.82460299
73CSNK1G20.81702994
74STK390.80195673
75SGK20.80069196
76CCNB10.78854782
77CAMK1G0.78178625
78TEC0.78074807
79NLK0.77944711
80ATR0.75559837
81PRKCE0.75516173
82NTRK30.71910362
83ERBB30.71092685
84FLT30.71048618
85NTRK20.70239251
86BRD40.68332457
87MARK20.67309036
88NME10.67278847
89RPS6KB20.66439072
90OXSR10.66263980
91CAMK10.65291561
92IKBKE0.64853066
93FGFR30.64774880
94SGK30.63249420
95ERBB40.63178531
96MAP3K130.62575779
97CAMK2A0.62184167
98MAPKAPK50.61860594
99TNK20.61174656
100IKBKB0.60830278
101GRK70.59697518
102RPS6KA60.59524074
103RPS6KB10.58247932
104PRKACA0.56798704
105PRKD30.55994045
106YES10.55398032
107STK30.55117287
108TAOK30.54968037
109PRKCZ0.53803136
110SYK0.53679292
111DYRK1A0.53051792
112ATM0.52127326
113CSNK1A1L0.51975031
114CSNK1A10.50984037
115CHUK0.50834905
116ERBB20.50767106
117RAF10.50433855
118GRK10.50006586
119CDK60.49787879
120ITK0.49279770
121STK160.49058243
122IRAK10.48686525
123DMPK0.47897252
124PKN10.47426846
125MAPK40.46337307
126SGK10.44838691
127PTK2B0.44509401
128TAF10.43421633
129PRKCQ0.43076852
130PRKAA20.42861372
131BRSK20.42237138
132AURKB0.41993261
133PNCK0.41848703
134LYN0.41294218
135UHMK10.41092810
136PASK0.40782289
137IRAK20.39657707
138CAMK40.38795421
139RPS6KA50.38667308
140CAMK2B0.36603872
141MAPK90.36188953
142STK110.35103051
143CDK70.33947950
144BLK0.33931074
145AKT10.33782556
146MAPK140.33367185
147MAP2K40.32770269
148PRKCA0.32736396
149PRKACG0.32033334
150FGFR20.31880290
151CSNK1D0.30958597
152ZAP700.30791704
153KIT0.30717363
154PHKG20.30601479

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.94644884
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.84786617
3RNA degradation_Homo sapiens_hsa030182.20423541
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.08625252
5Linoleic acid metabolism_Homo sapiens_hsa005911.99155018
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.98191359
7Nitrogen metabolism_Homo sapiens_hsa009101.86801931
8Cell cycle_Homo sapiens_hsa041101.84843712
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.84643318
10Ribosome_Homo sapiens_hsa030101.83634639
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.63113368
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58785793
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56765702
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50190211
15Basal transcription factors_Homo sapiens_hsa030221.49033725
16Renin secretion_Homo sapiens_hsa049241.41967125
17Spliceosome_Homo sapiens_hsa030401.40702446
18Fanconi anemia pathway_Homo sapiens_hsa034601.37617072
19Insulin secretion_Homo sapiens_hsa049111.37013604
20mRNA surveillance pathway_Homo sapiens_hsa030151.36266999
21Ether lipid metabolism_Homo sapiens_hsa005651.34895558
22Oxidative phosphorylation_Homo sapiens_hsa001901.34344782
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31082143
24* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29802036
25Tryptophan metabolism_Homo sapiens_hsa003801.27963931
26RNA polymerase_Homo sapiens_hsa030201.27412319
27GABAergic synapse_Homo sapiens_hsa047271.21873645
28Nicotine addiction_Homo sapiens_hsa050331.21662834
29Basal cell carcinoma_Homo sapiens_hsa052171.21403928
30Parkinsons disease_Homo sapiens_hsa050121.19292043
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19055245
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.19011970
33Butanoate metabolism_Homo sapiens_hsa006501.15993748
34Prolactin signaling pathway_Homo sapiens_hsa049171.15088838
35Salivary secretion_Homo sapiens_hsa049701.15029952
36Sulfur metabolism_Homo sapiens_hsa009201.14260329
37Dorso-ventral axis formation_Homo sapiens_hsa043201.14173555
38p53 signaling pathway_Homo sapiens_hsa041151.13841730
39Primary immunodeficiency_Homo sapiens_hsa053401.13451572
40Amphetamine addiction_Homo sapiens_hsa050311.13231556
41Mismatch repair_Homo sapiens_hsa034301.10837127
42Cocaine addiction_Homo sapiens_hsa050301.10191580
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10020495
44Cardiac muscle contraction_Homo sapiens_hsa042601.09057214
45Circadian rhythm_Homo sapiens_hsa047101.09053447
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.08403106
47Platelet activation_Homo sapiens_hsa046111.08402696
48Wnt signaling pathway_Homo sapiens_hsa043101.07859616
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07433732
50T cell receptor signaling pathway_Homo sapiens_hsa046601.07043744
51DNA replication_Homo sapiens_hsa030301.06199570
52Asthma_Homo sapiens_hsa053101.03973282
53Nucleotide excision repair_Homo sapiens_hsa034201.03649809
54Retinol metabolism_Homo sapiens_hsa008301.03440656
55Chemical carcinogenesis_Homo sapiens_hsa052041.03356945
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03221587
57Propanoate metabolism_Homo sapiens_hsa006401.03160903
58Homologous recombination_Homo sapiens_hsa034401.02847674
59Colorectal cancer_Homo sapiens_hsa052101.02744462
60Caffeine metabolism_Homo sapiens_hsa002321.02566261
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01824298
62Measles_Homo sapiens_hsa051620.98765731
63MicroRNAs in cancer_Homo sapiens_hsa052060.97131983
64Axon guidance_Homo sapiens_hsa043600.97080800
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96666525
66Serotonergic synapse_Homo sapiens_hsa047260.96555585
67Base excision repair_Homo sapiens_hsa034100.94849890
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94570358
69RNA transport_Homo sapiens_hsa030130.94365782
70Hepatitis B_Homo sapiens_hsa051610.93524614
71Oocyte meiosis_Homo sapiens_hsa041140.92988866
72Non-small cell lung cancer_Homo sapiens_hsa052230.92313661
73Chronic myeloid leukemia_Homo sapiens_hsa052200.92007648
74Herpes simplex infection_Homo sapiens_hsa051680.91857045
75Long-term depression_Homo sapiens_hsa047300.91671756
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91629349
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90984833
78Viral myocarditis_Homo sapiens_hsa054160.90309093
79Regulation of autophagy_Homo sapiens_hsa041400.90018950
80Glycerolipid metabolism_Homo sapiens_hsa005610.89012567
81Pancreatic cancer_Homo sapiens_hsa052120.88146287
82Hematopoietic cell lineage_Homo sapiens_hsa046400.87451881
83Gastric acid secretion_Homo sapiens_hsa049710.86170521
84Long-term potentiation_Homo sapiens_hsa047200.85877591
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85632236
86Taste transduction_Homo sapiens_hsa047420.85308943
87Endometrial cancer_Homo sapiens_hsa052130.84749108
88Ovarian steroidogenesis_Homo sapiens_hsa049130.83204621
89Non-homologous end-joining_Homo sapiens_hsa034500.82502946
90Glutamatergic synapse_Homo sapiens_hsa047240.82179001
91Notch signaling pathway_Homo sapiens_hsa043300.82128923
92Melanogenesis_Homo sapiens_hsa049160.82032047
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81927914
94Circadian entrainment_Homo sapiens_hsa047130.80340512
95HTLV-I infection_Homo sapiens_hsa051660.79308172
96Arachidonic acid metabolism_Homo sapiens_hsa005900.79134946
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79038259
98Autoimmune thyroid disease_Homo sapiens_hsa053200.79030809
99Peroxisome_Homo sapiens_hsa041460.78448008
100Purine metabolism_Homo sapiens_hsa002300.78306482
101Oxytocin signaling pathway_Homo sapiens_hsa049210.78181626
102Alzheimers disease_Homo sapiens_hsa050100.78000398
103Allograft rejection_Homo sapiens_hsa053300.75918744
104Hedgehog signaling pathway_Homo sapiens_hsa043400.75898156
105TGF-beta signaling pathway_Homo sapiens_hsa043500.75543653
106Systemic lupus erythematosus_Homo sapiens_hsa053220.75161173
107FoxO signaling pathway_Homo sapiens_hsa040680.74834180
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.74314394
109Calcium signaling pathway_Homo sapiens_hsa040200.74311469
110ErbB signaling pathway_Homo sapiens_hsa040120.74222779
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73544990
112Type II diabetes mellitus_Homo sapiens_hsa049300.73281574
113Choline metabolism in cancer_Homo sapiens_hsa052310.72900387
114Cholinergic synapse_Homo sapiens_hsa047250.72007739
115Alcoholism_Homo sapiens_hsa050340.71683482
116Pyrimidine metabolism_Homo sapiens_hsa002400.71616603
117Acute myeloid leukemia_Homo sapiens_hsa052210.71611811
118Selenocompound metabolism_Homo sapiens_hsa004500.70630057
119Protein export_Homo sapiens_hsa030600.70242898
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69550168
121Olfactory transduction_Homo sapiens_hsa047400.69053998
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68779305
123Dopaminergic synapse_Homo sapiens_hsa047280.68270440
124Pathways in cancer_Homo sapiens_hsa052000.67337129
125Renal cell carcinoma_Homo sapiens_hsa052110.66576080
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66288680
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64792241
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64586729
129Thyroid cancer_Homo sapiens_hsa052160.64319879
130GnRH signaling pathway_Homo sapiens_hsa049120.64084432
131Huntingtons disease_Homo sapiens_hsa050160.64014087
132VEGF signaling pathway_Homo sapiens_hsa043700.63998996
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62898788
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62515977
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61997302
136Small cell lung cancer_Homo sapiens_hsa052220.61823700
137Prostate cancer_Homo sapiens_hsa052150.61800088
138MAPK signaling pathway_Homo sapiens_hsa040100.61452004
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61246585
140Rap1 signaling pathway_Homo sapiens_hsa040150.60883119
141Ras signaling pathway_Homo sapiens_hsa040140.59637046
142Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59523001
143cAMP signaling pathway_Homo sapiens_hsa040240.59177709
144Morphine addiction_Homo sapiens_hsa050320.58984045
145B cell receptor signaling pathway_Homo sapiens_hsa046620.58697429
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58553687
147Dilated cardiomyopathy_Homo sapiens_hsa054140.56964671
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56154069
149Graft-versus-host disease_Homo sapiens_hsa053320.55000378
150Melanoma_Homo sapiens_hsa052180.52924237
151Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50588914
152Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50514442
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.50097377
154Sulfur relay system_Homo sapiens_hsa041220.48066414
155Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47483576
156Type I diabetes mellitus_Homo sapiens_hsa049400.46321223
157Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45709802
158Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45681209
159Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42101391
160Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36517031
161Vitamin digestion and absorption_Homo sapiens_hsa049770.34832881
162Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33449730

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