MLLT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)7.90554610
2polyketide metabolic process (GO:0030638)7.90554610
3doxorubicin metabolic process (GO:0044598)7.90554610
4maintenance of protein location in nucleus (GO:0051457)5.98495067
5histone H4-K5 acetylation (GO:0043981)5.38781545
6histone H4-K8 acetylation (GO:0043982)5.38781545
7positive regulation of gamma-delta T cell activation (GO:0046645)5.18585267
8histone H4-K12 acetylation (GO:0043983)5.18268263
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.13618455
10negative regulation of cell killing (GO:0031342)5.13618455
11aminoglycoside antibiotic metabolic process (GO:0030647)5.09931568
12somite rostral/caudal axis specification (GO:0032525)5.02520188
13regulation of MHC class I biosynthetic process (GO:0045343)4.95901613
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.87910584
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.76068624
16regulation of mammary gland epithelial cell proliferation (GO:0033599)4.73633452
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.64105290
18muscle organ morphogenesis (GO:0048644)4.60321627
19negative regulation of erythrocyte differentiation (GO:0045647)4.60034321
20interferon-gamma production (GO:0032609)4.59977676
21regulation of response to osmotic stress (GO:0047484)4.59743395
22histone H4-K16 acetylation (GO:0043984)4.56762926
23negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.52604630
24positive regulation of histone deacetylation (GO:0031065)4.52008306
25antigen processing and presentation of endogenous antigen (GO:0019883)4.48829709
26pre-miRNA processing (GO:0031054)4.48053743
27regulation of telomere maintenance via telomerase (GO:0032210)4.43408513
28negative regulation of telomerase activity (GO:0051974)4.38209533
29regulation of gamma-delta T cell activation (GO:0046643)4.36289035
30regulation of gamma-delta T cell differentiation (GO:0045586)4.33428854
31negative thymic T cell selection (GO:0045060)4.29169890
32positive thymic T cell selection (GO:0045059)4.26108103
33thymic T cell selection (GO:0045061)4.23012675
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.22860729
35protein localization to kinetochore (GO:0034501)4.22032461
36negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.20213386
37negative regulation of epidermis development (GO:0045683)4.16116180
38negative T cell selection (GO:0043383)4.14436333
39heterochromatin organization (GO:0070828)4.11886378
40positive regulation of protein deacetylation (GO:0090312)4.00512983
41regulation of nuclear cell cycle DNA replication (GO:0033262)3.98810289
42negative regulation of cell cycle G2/M phase transition (GO:1902750)3.92523522
43negative regulation of potassium ion transmembrane transport (GO:1901380)3.90757059
44nuclear pore complex assembly (GO:0051292)3.82457371
45T cell selection (GO:0045058)3.81956937
46positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.79444551
47synaptic vesicle maturation (GO:0016188)3.74337442
48positive T cell selection (GO:0043368)3.72863826
49retinoic acid receptor signaling pathway (GO:0048384)3.62859796
50rRNA transcription (GO:0009303)3.60109387
51mannose metabolic process (GO:0006013)3.57425970
52positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.57329307
53hypotonic response (GO:0006971)3.57158697
54histone H3-K4 methylation (GO:0051568)3.56548300
55NLS-bearing protein import into nucleus (GO:0006607)3.54159152
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.54134736
57leukocyte aggregation (GO:0070486)3.53477585
58regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.51548692
59branching involved in mammary gland duct morphogenesis (GO:0060444)3.51443652
60response to interleukin-15 (GO:0070672)3.49517298
61response to dietary excess (GO:0002021)3.49267987
62hormone catabolic process (GO:0042447)3.45268836
63chromatin assembly (GO:0031497)3.45220569
64mitochondrion distribution (GO:0048311)3.45218818
65cytidine metabolic process (GO:0046087)3.44809335
66cytidine catabolic process (GO:0006216)3.44809335
67cytidine deamination (GO:0009972)3.44809335
68intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.44761640
69proline transport (GO:0015824)3.44149839
70response to muramyl dipeptide (GO:0032495)3.43396856
71germinal center formation (GO:0002467)3.36497923
72primitive streak formation (GO:0090009)3.35529259
73RNA stabilization (GO:0043489)3.35393384
74mRNA stabilization (GO:0048255)3.35393384
75tolerance induction (GO:0002507)3.35256375
76intracellular estrogen receptor signaling pathway (GO:0030520)3.29248220
77notochord development (GO:0030903)3.27417783
78mitotic sister chromatid segregation (GO:0000070)3.27205204
79regulation of B cell receptor signaling pathway (GO:0050855)3.26629021
80regulation of T cell tolerance induction (GO:0002664)3.19096585
81maintenance of protein localization in organelle (GO:0072595)3.18571598
82trophectodermal cell differentiation (GO:0001829)3.17280295
83T cell migration (GO:0072678)3.15901549
84nuclear pore organization (GO:0006999)3.11354390
85tachykinin receptor signaling pathway (GO:0007217)3.10277003
86establishment of endothelial barrier (GO:0061028)3.09019268
87detection of bacterium (GO:0016045)3.08860895
88B cell receptor signaling pathway (GO:0050853)3.06911409
89intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.06656488
90positive regulation of Rap GTPase activity (GO:0032854)3.06539760
91intestinal epithelial cell development (GO:0060576)3.05775925
92negative regulation of viral release from host cell (GO:1902187)3.04929672
93positive regulation of macrophage cytokine production (GO:0060907)3.04556699
94signal complex assembly (GO:0007172)3.04073120
95modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.03691220
96modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.03691220
97positive regulation by organism of defense response of other organism involved in symbiotic interact3.03691220
98modulation by symbiont of host immune response (GO:0052553)3.03691220
99positive regulation by symbiont of host defense response (GO:0052509)3.03691220
100modulation by symbiont of host defense response (GO:0052031)3.03691220
101maternal placenta development (GO:0001893)3.02956391
102negative regulation of T cell mediated immunity (GO:0002710)3.00580317
103detection of other organism (GO:0098543)3.00468586
104negative regulation of lymphocyte mediated immunity (GO:0002707)3.00121716
105response to type I interferon (GO:0034340)2.98098306
106NIK/NF-kappaB signaling (GO:0038061)2.94115900
107positive regulation of DNA-dependent DNA replication (GO:2000105)2.93428706
108regulation of ARF protein signal transduction (GO:0032012)2.93044985
109negative regulation of epidermal cell differentiation (GO:0045605)2.92472417
110cell fate commitment involved in formation of primary germ layer (GO:0060795)2.91855198
111cellular response to type I interferon (GO:0071357)2.90830979
112type I interferon signaling pathway (GO:0060337)2.90830979
113adaptation of signaling pathway (GO:0023058)2.90570108
114macrophage activation involved in immune response (GO:0002281)2.89112741
115cellular response to interleukin-15 (GO:0071350)2.89104758
116protein localization to chromosome, centromeric region (GO:0071459)2.88825359
117phenol-containing compound catabolic process (GO:0019336)2.88673869
118cardiovascular system development (GO:0072358)2.88386101
119negative regulation of leukocyte mediated immunity (GO:0002704)2.88150410
120sister chromatid segregation (GO:0000819)2.87587253
121activated T cell proliferation (GO:0050798)2.86696307
122regulation of cilium movement (GO:0003352)2.85135035
123response to laminar fluid shear stress (GO:0034616)2.84510079
124nucleoside transmembrane transport (GO:1901642)2.84240527
125regulation of tolerance induction (GO:0002643)2.83503952
126regulation of interleukin-2 biosynthetic process (GO:0045076)2.83273881
127regulation of gene silencing by RNA (GO:0060966)2.82042062
128regulation of posttranscriptional gene silencing (GO:0060147)2.82042062
129regulation of gene silencing by miRNA (GO:0060964)2.82042062
130regulation of apoptotic process involved in morphogenesis (GO:1902337)2.81389259
131embryonic placenta development (GO:0001892)2.80345326
132negative regulation of telomere maintenance (GO:0032205)2.80322422
133epithelial cell differentiation involved in prostate gland development (GO:0060742)2.79576514
134regulation of translation in response to stress (GO:0043555)2.78860081
135regulation of telomere maintenance (GO:0032204)2.78239204
136regulation of type I interferon-mediated signaling pathway (GO:0060338)2.78229665
137vitamin A metabolic process (GO:0006776)2.77829787
138pyrimidine ribonucleoside catabolic process (GO:0046133)2.77178219
139histone H3-K36 demethylation (GO:0070544)2.76437554
140regulation of extracellular matrix disassembly (GO:0010715)2.76084269
141negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.73798539
142CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.73139565
143regulation of Rap GTPase activity (GO:0032317)2.72930848
144regulation of hippo signaling (GO:0035330)2.71464586
145regulation of histone H3-K27 methylation (GO:0061085)2.70516904
146positive regulation of tolerance induction (GO:0002645)2.69019121
147pore complex assembly (GO:0046931)2.68084587
148stress granule assembly (GO:0034063)2.67730430
149Peyers patch development (GO:0048541)2.66899096
150mucosal-associated lymphoid tissue development (GO:0048537)2.66899096
151regulation of necroptotic process (GO:0060544)2.66646900
152histone H3-K4 trimethylation (GO:0080182)2.65432191
153negative regulation of interleukin-2 production (GO:0032703)2.65039448
154positive regulation of granulocyte differentiation (GO:0030854)2.63117612
155regulation of dendritic cell antigen processing and presentation (GO:0002604)2.62128820
156regulation of ARF GTPase activity (GO:0032312)2.62091285
157icosanoid secretion (GO:0032309)2.61995534
158arachidonic acid secretion (GO:0050482)2.61995534
159cellular extravasation (GO:0045123)2.61841066
160response to peptidoglycan (GO:0032494)2.61629317
161negative regulation of cell size (GO:0045792)2.60967776
162natural killer cell differentiation (GO:0001779)2.58356992
163positive regulation of gene expression, epigenetic (GO:0045815)2.58254034
164positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.57712432
165regulation of glucose import in response to insulin stimulus (GO:2001273)2.55807640
166branching involved in labyrinthine layer morphogenesis (GO:0060670)2.55545743
167negative regulation of interleukin-12 production (GO:0032695)2.54659466
168positive regulation of CREB transcription factor activity (GO:0032793)2.54315183
169regulation of granulocyte differentiation (GO:0030852)2.53962552
170regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.53907951
171regulation of natural killer cell mediated immunity (GO:0002715)2.53907951
172negative regulation of granulocyte differentiation (GO:0030853)2.53061266
173negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.52012329
174regulation of alpha-beta T cell proliferation (GO:0046640)2.49003539
175antigen processing and presentation via MHC class Ib (GO:0002475)2.48757960
176negative regulation of innate immune response (GO:0045824)2.47583354
177myeloid dendritic cell differentiation (GO:0043011)2.46053799
178interferon-gamma-mediated signaling pathway (GO:0060333)2.44816413
179negative regulation of myotube differentiation (GO:0010832)2.43835121
180antigen receptor-mediated signaling pathway (GO:0050851)2.43683026
181negative regulation of cytokine production involved in immune response (GO:0002719)2.43678512
182regulation of T-helper 2 cell differentiation (GO:0045628)2.42723042
183positive regulation of B cell differentiation (GO:0045579)2.42606721
184regulation of B cell differentiation (GO:0045577)2.42127996
185modulation by symbiont of host cellular process (GO:0044068)2.41684386
186detection of external biotic stimulus (GO:0098581)2.41350039
187negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.41218185
188T cell receptor signaling pathway (GO:0050852)2.40713275
189negative regulation of type 2 immune response (GO:0002829)2.39997753
190regulation of interferon-beta biosynthetic process (GO:0045357)2.39584860
191regulation of regulatory T cell differentiation (GO:0045589)2.36714138
192lymphocyte migration (GO:0072676)2.36338822
193JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.34761425
194modulation by virus of host process (GO:0019054)2.34288291

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.80264722
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.63468323
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.63468323
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.63468323
5* SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.24850846
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.13954953
7* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.72326539
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.67799658
9* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.56048167
10* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.43619782
11* MYC_22102868_ChIP-Seq_BL_Human2.36793785
12* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.32590138
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31293183
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.26206088
15RUNX_20019798_ChIP-Seq_JUKART_Human2.25219355
16* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.18741408
17VDR_24763502_ChIP-Seq_THP-1_Human2.13006257
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12478326
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.12184786
20* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.10813123
21* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.10056595
22* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.09711793
23* TCF7_22412390_ChIP-Seq_EML_Mouse2.04054347
24* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.02989850
25* NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.02973623
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98102007
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97892141
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97248106
29TCF3_18692474_ChIP-Seq_MEFs_Mouse1.95661879
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88747215
31* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85853075
32* MAF_26560356_Chip-Seq_TH2_Human1.83443108
33* KDM2B_26808549_Chip-Seq_DND41_Human1.80056166
34* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.78999542
35* KDM2B_26808549_Chip-Seq_K562_Human1.78154407
36* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78049549
37E2F7_22180533_ChIP-Seq_HELA_Human1.77525366
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75714959
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74749671
40* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.74391212
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74178256
42* RUNX1_22412390_ChIP-Seq_EML_Mouse1.74163986
43POU5F1_16518401_ChIP-PET_MESCs_Mouse1.70747486
44* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.66673785
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66215503
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65528378
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.62442326
48* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62217291
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59121913
50* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59027555
51* TP63_19390658_ChIP-ChIP_HaCaT_Human1.58478850
52* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58474195
53* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57178399
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55112602
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.54574583
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.53985916
57* MYB_26560356_Chip-Seq_TH2_Human1.51787203
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50908778
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50823081
60* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.50744061
61* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49373812
62LXR_22292898_ChIP-Seq_THP-1_Human1.47716650
63* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46898187
64* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.46479241
65DROSHA_22980978_ChIP-Seq_HELA_Human1.45521934
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44380572
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.44195398
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.43210015
69* ELK3_25401928_ChIP-Seq_HUVEC_Human1.42148747
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37767205
71* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37673064
72* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37478182
73* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.37225917
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.34687991
75* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.32613191
76SMC4_20622854_ChIP-Seq_HELA_Human1.31122461
77* NCOR1_26117541_ChIP-Seq_K562_Human1.30626247
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28400711
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27697844
80CDX2_20551321_ChIP-Seq_CACO-2_Human1.26656721
81* RARB_27405468_Chip-Seq_BRAIN_Mouse1.24637903
82* RACK7_27058665_Chip-Seq_MCF-7_Human1.24473598
83* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23992812
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23799465
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23022942
86* KDM2B_26808549_Chip-Seq_JURKAT_Human1.22768653
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22629801
88FOXM1_23109430_ChIP-Seq_U2OS_Human1.22128789
89GATA1_19941826_ChIP-Seq_K562_Human1.21861612
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21417570
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20612848
92* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.16644100
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16351001
94FOXO3_23340844_ChIP-Seq_DLD1_Human1.15866091
95* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15586905
96TP53_22127205_ChIP-Seq_IMR90_Human1.14830289
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.14198540
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12965638
99* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.12104534
100VDR_21846776_ChIP-Seq_THP-1_Human1.11881126
101NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11252946
102* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.09483523
103IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08553045
104GATA3_27048872_Chip-Seq_THYMUS_Human1.08443296
105BCL6_27268052_Chip-Seq_Bcells_Human1.08244286
106* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06632986
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06187215
108P68_20966046_ChIP-Seq_HELA_Human1.05730134
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05483716
110* NANOG_16518401_ChIP-PET_MESCs_Mouse1.05027684
111SPI1_23127762_ChIP-Seq_K562_Human1.04299171
112PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04110623
113* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03498039
114* SPI1_23547873_ChIP-Seq_NB4_Human1.03133303
115PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02675398
116* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02510751
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02157054
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01877232
119* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01831852
120* MAF_26560356_Chip-Seq_TH1_Human1.01785648
121* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01287114
122OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01216031
123ERG_21242973_ChIP-ChIP_JURKAT_Human1.01082889
124* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00882797
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00781027
126* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99680741
127PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99604987
128* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99045332
129TET1_21451524_ChIP-Seq_MESCs_Mouse0.98950244
130* CREB1_26743006_Chip-Seq_LNCaP_Human0.98572967
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98451388
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97189505
133PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96893312
134* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93844801
135CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93428769
136* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93273091
137* UTX_26944678_Chip-Seq_JUKART_Human0.92999647
138* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92251470
139RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92211967
140* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91922297
141VDR_24787735_ChIP-Seq_THP-1_Human0.91873331
142TP63_22573176_ChIP-Seq_HFKS_Human0.91533665
143SCL_19346495_ChIP-Seq_HPC-7_Human0.91447338
144* RING1B_27294783_Chip-Seq_NPCs_Mouse0.90185866
145MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89627440
146RUNX1_27514584_Chip-Seq_MCF-7_Human0.88991941
147CTCF_21964334_Chip-Seq_Bcells_Human0.87552804
148ELF1_20517297_ChIP-Seq_JURKAT_Human0.86736689
149FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86306236
150DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85360228
151* MYB_26560356_Chip-Seq_TH1_Human0.81488498
152BCOR_27268052_Chip-Seq_Bcells_Human0.81174992
153ELK4_26923725_Chip-Seq_MESODERM_Mouse0.80488922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.30540291
2MP0003011_delayed_dark_adaptation3.95604674
3MP0004858_abnormal_nervous_system3.77921861
4MP0003436_decreased_susceptibility_to3.56334603
5MP0004264_abnormal_extraembryonic_tissu3.54390581
6MP0008961_abnormal_basal_metabolism3.14782164
7MP0003890_abnormal_embryonic-extraembry3.11103206
8MP0003705_abnormal_hypodermis_morpholog3.04883572
9MP0005499_abnormal_olfactory_system2.95430629
10MP0005394_taste/olfaction_phenotype2.95430629
11MP0002332_abnormal_exercise_endurance2.81621879
12MP0006292_abnormal_olfactory_placode2.77502219
13MP0001835_abnormal_antigen_presentation2.73028444
14MP0010352_gastrointestinal_tract_polyps2.64754649
15MP0003724_increased_susceptibility_to2.63266467
16MP0005671_abnormal_response_to2.56372345
17MP0000685_abnormal_immune_system2.43625770
18MP0005000_abnormal_immune_tolerance2.41730103
19MP0005025_abnormal_response_to2.26257502
20MP0005451_abnormal_body_composition2.21493559
21MP0002653_abnormal_ependyma_morphology2.16648388
22MP0002723_abnormal_immune_serum2.15850345
23MP0003122_maternal_imprinting2.12399664
24MP0008057_abnormal_DNA_replication2.12107288
25MP0004947_skin_inflammation2.11605934
26MP0001873_stomach_inflammation2.10946428
27MP0009333_abnormal_splenocyte_physiolog2.09083733
28MP0005075_abnormal_melanosome_morpholog2.08582997
29MP0002419_abnormal_innate_immunity2.07485518
30MP0002420_abnormal_adaptive_immunity2.07123150
31MP0001819_abnormal_immune_cell2.04651856
32MP0002452_abnormal_antigen_presenting2.03311994
33MP0010155_abnormal_intestine_physiology2.01739012
34MP0005058_abnormal_lysosome_morphology1.83667706
35MP0009278_abnormal_bone_marrow1.79110424
36MP0002398_abnormal_bone_marrow1.77881426
37MP0003866_abnormal_defecation1.76693324
38MP0002127_abnormal_cardiovascular_syste1.74498723
39MP0003121_genomic_imprinting1.73439084
40MP0001849_ear_inflammation1.72596011
41MP0004381_abnormal_hair_follicle1.72253226
42MP0009785_altered_susceptibility_to1.70652510
43MP0000716_abnormal_immune_system1.69051712
44MP0005257_abnormal_intraocular_pressure1.65839671
45MP0005380_embryogenesis_phenotype1.65682082
46MP0001672_abnormal_embryogenesis/_devel1.65682082
47MP0002933_joint_inflammation1.64894390
48MP0001533_abnormal_skeleton_physiology1.63131564
49MP0002088_abnormal_embryonic_growth/wei1.62701035
50MP0003984_embryonic_growth_retardation1.60439202
51MP0006082_CNS_inflammation1.58053355
52MP0008260_abnormal_autophagy1.56911010
53MP0003787_abnormal_imprinting1.53552159
54MP0006035_abnormal_mitochondrial_morpho1.52067405
55MP0003191_abnormal_cellular_cholesterol1.49460875
56MP0002148_abnormal_hypersensitivity_rea1.47524600
57MP0002998_abnormal_bone_remodeling1.46578798
58MP0002166_altered_tumor_susceptibility1.43533411
59MP0004859_abnormal_synaptic_plasticity1.38591061
60MP0003183_abnormal_peptide_metabolism1.36917829
61MP0004957_abnormal_blastocyst_morpholog1.35453461
62MP0005409_darkened_coat_color1.34051731
63MP0001845_abnormal_inflammatory_respons1.34015958
64MP0002086_abnormal_extraembryonic_tissu1.33650638
65MP0000858_altered_metastatic_potential1.31905976
66MP0003283_abnormal_digestive_organ1.31778732
67MP0002429_abnormal_blood_cell1.31634788
68MP0002722_abnormal_immune_system1.31483478
69MP0002009_preneoplasia1.31184216
70MP0000678_abnormal_parathyroid_gland1.28917317
71MP0002277_abnormal_respiratory_mucosa1.28439174
72MP0001348_abnormal_lacrimal_gland1.27723436
73MP0000689_abnormal_spleen_morphology1.26678015
74MP0003690_abnormal_glial_cell1.25645990
75MP0001851_eye_inflammation1.24572160
76MP0000350_abnormal_cell_proliferation1.21157762
77MP0005464_abnormal_platelet_physiology1.20450100
78MP0004130_abnormal_muscle_cell1.20404695
79MP0003045_fibrosis1.18225143
80MP0003453_abnormal_keratinocyte_physiol1.16845469
81MP0005666_abnormal_adipose_tissue1.16343853
82MP0002396_abnormal_hematopoietic_system1.15713506
83MP0008770_decreased_survivor_rate1.14792229
84MP0005623_abnormal_meninges_morphology1.14540543
85MP0001293_anophthalmia1.14448162
86MP0003137_abnormal_impulse_conducting1.13975987
87MP0009840_abnormal_foam_cell1.13539738
88MP0002925_abnormal_cardiovascular_devel1.12101504
89MP0002909_abnormal_adrenal_gland1.09939371
90MP0002092_abnormal_eye_morphology1.09505955
91MP0002084_abnormal_developmental_patter1.07556839
92MP0002085_abnormal_embryonic_tissue1.06694732
93MP0005076_abnormal_cell_differentiation1.06340674
94MP0004043_abnormal_pH_regulation1.02724813
95MP0005166_decreased_susceptibility_to1.02563200
96MP0003938_abnormal_ear_development1.02392711
97MP0008469_abnormal_protein_level1.01178060
98MP0004808_abnormal_hematopoietic_stem0.99941175
99MP0002269_muscular_atrophy0.97511062
100MP0001853_heart_inflammation0.95967832
101MP0004197_abnormal_fetal_growth/weight/0.95826779
102MP0003119_abnormal_digestive_system0.95084966
103MP0000428_abnormal_craniofacial_morphol0.94207382
104MP0003279_aneurysm0.91707239
105MP0010630_abnormal_cardiac_muscle0.91525456
106MP0005391_vision/eye_phenotype0.90421689
107MP0003935_abnormal_craniofacial_develop0.89265296
108MP0005253_abnormal_eye_physiology0.88403672
109MP0003300_gastrointestinal_ulcer0.88375400
110MP0001790_abnormal_immune_system0.88321870
111MP0005387_immune_system_phenotype0.88321870
112MP0002132_abnormal_respiratory_system0.88067853
113MP0002932_abnormal_joint_morphology0.87543824
114MP0003075_altered_response_to0.87203598
115MP0003448_altered_tumor_morphology0.86828983
116MP0000733_abnormal_muscle_development0.86801041
117MP0004185_abnormal_adipocyte_glucose0.86583872
118MP0000749_muscle_degeneration0.86458835
119MP0005310_abnormal_salivary_gland0.85884255
120MP0004084_abnormal_cardiac_muscle0.85755674
121MP0005248_abnormal_Harderian_gland0.85754246
122MP0005375_adipose_tissue_phenotype0.85236480
123MP0000750_abnormal_muscle_regeneration0.85069936
124MP0002970_abnormal_white_adipose0.84782831
125MP0005266_abnormal_metabolism0.83633036
126MP0004510_myositis0.83623825
127MP0003828_pulmonary_edema0.82136732
128MP0003303_peritoneal_inflammation0.82130671
129MP0003091_abnormal_cell_migration0.81664125
130MP0000249_abnormal_blood_vessel0.81480064
131MP0004087_abnormal_muscle_fiber0.80975230
132MP0005397_hematopoietic_system_phenotyp0.80408381
133MP0001545_abnormal_hematopoietic_system0.80408381
134MP0000465_gastrointestinal_hemorrhage0.80107164
135MP0000604_amyloidosis0.80011400
136MP0001663_abnormal_digestive_system0.79935373
137MP0003123_paternal_imprinting0.79679215
138MP0005023_abnormal_wound_healing0.78042715
139MP0003172_abnormal_lysosome_physiology0.77439397
140MP0005167_abnormal_blood-brain_barrier0.77034814
141MP0009115_abnormal_fat_cell0.76877680
142MP0002006_tumorigenesis0.76864215
143MP0005670_abnormal_white_adipose0.76740432
144MP0001800_abnormal_humoral_immune0.76432601
145MP0002138_abnormal_hepatobiliary_system0.76097283
146MP0008874_decreased_physiological_sensi0.75008472
147MP0001958_emphysema0.74511307
148MP0010030_abnormal_orbit_morphology0.74113056
149MP0002877_abnormal_melanocyte_morpholog0.74015080
150MP0005390_skeleton_phenotype0.73090341
151MP0002114_abnormal_axial_skeleton0.73083842
152MP0004883_abnormal_blood_vessel0.72943882
153MP0000759_abnormal_skeletal_muscle0.72278957
154MP0003566_abnormal_cell_adhesion0.71724684
155MP0000432_abnormal_head_morphology0.71569610
156MP0002822_catalepsy0.71350015
157MP0001730_embryonic_growth_arrest0.71171221
158MP0003329_amyloid_beta_deposits0.70836762
159MP0009046_muscle_twitch0.69204225
160MP0001697_abnormal_embryo_size0.69203463
161MP0003763_abnormal_thymus_physiology0.68847049
162MP0000313_abnormal_cell_death0.68428888
163MP0008789_abnormal_olfactory_epithelium0.67664673
164MP0008004_abnormal_stomach_pH0.67009912
165MP0003879_abnormal_hair_cell0.66970035
166MP0008569_lethality_at_weaning0.66825314
167MP0000703_abnormal_thymus_morphology0.66693108
168MP0000266_abnormal_heart_morphology0.65613949
169MP0002405_respiratory_system_inflammati0.64274914
170MP0009703_decreased_birth_body0.64100548
171MP0002080_prenatal_lethality0.64038224
172MP0004085_abnormal_heartbeat0.62579695

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.12337495
2Abnormality of the lower motor neuron (HP:0002366)5.35721367
3Hypochromic microcytic anemia (HP:0004840)5.10077766
4Eczematoid dermatitis (HP:0000976)4.73463634
5Hepatoblastoma (HP:0002884)4.71987132
6Ependymoma (HP:0002888)4.38318922
7Multiple enchondromatosis (HP:0005701)4.21359772
8Rib fusion (HP:0000902)4.07414347
9Obstructive sleep apnea (HP:0002870)3.92090621
10Abnormality of the fingertips (HP:0001211)3.80860797
11Neoplasm of striated muscle (HP:0009728)3.54282738
12Abnormality of the astrocytes (HP:0100707)3.45983501
13Astrocytoma (HP:0009592)3.45983501
14Difficulty running (HP:0009046)3.27733350
15Myositis (HP:0100614)3.17436579
16Increased IgE level (HP:0003212)3.17351410
17Pustule (HP:0200039)3.07280251
18Colitis (HP:0002583)3.06422528
19Testicular atrophy (HP:0000029)3.06234847
20Rhabdomyosarcoma (HP:0002859)2.98971682
21Abnormality of the salivary glands (HP:0010286)2.98769162
22Broad face (HP:0000283)2.97233679
23Intestinal fistula (HP:0100819)2.97023052
24Amyotrophic lateral sclerosis (HP:0007354)2.95827796
25Recurrent fungal infections (HP:0002841)2.94045943
26Recurrent bacterial skin infections (HP:0005406)2.91307715
27Neoplasm of the heart (HP:0100544)2.89147597
28Recurrent abscess formation (HP:0002722)2.88170109
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.82878823
30Abnormality of macrophages (HP:0004311)2.82153649
31Horizontal nystagmus (HP:0000666)2.77433427
32Resting tremor (HP:0002322)2.75955018
33Orchitis (HP:0100796)2.73941729
34Gastrointestinal inflammation (HP:0004386)2.72961759
35Gastrointestinal infarctions (HP:0005244)2.70954859
36Meningitis (HP:0001287)2.68132451
37Fused cervical vertebrae (HP:0002949)2.64934101
38Inflammation of the large intestine (HP:0002037)2.62710255
39Panhypogammaglobulinemia (HP:0003139)2.62143828
40Increased connective tissue (HP:0009025)2.61409428
41Generalized hypotonia (HP:0001290)2.59631239
42Large earlobe (HP:0009748)2.59103294
43Papilledema (HP:0001085)2.58125532
44Spontaneous hematomas (HP:0007420)2.57864757
45Recurrent viral infections (HP:0004429)2.57626070
46Optic neuritis (HP:0100653)2.56917193
47Retrobulbar optic neuritis (HP:0100654)2.56917193
48Cellulitis (HP:0100658)2.56632921
49Short humerus (HP:0005792)2.56351411
50Hand muscle atrophy (HP:0009130)2.56211682
51Gingivitis (HP:0000230)2.55786324
52Rectal fistula (HP:0100590)2.54170997
53Rectovaginal fistula (HP:0000143)2.54170997
54Elevated erythrocyte sedimentation rate (HP:0003565)2.52668864
55Nephroblastoma (Wilms tumor) (HP:0002667)2.51311566
56Cerebral aneurysm (HP:0004944)2.49497692
57T lymphocytopenia (HP:0005403)2.49242446
58Mediastinal lymphadenopathy (HP:0100721)2.48889167
59Vasculitis (HP:0002633)2.46791668
60Upper limb amyotrophy (HP:0009129)2.45640748
61Distal upper limb amyotrophy (HP:0007149)2.45640748
62Preauricular skin tag (HP:0000384)2.41574379
63Macroorchidism (HP:0000053)2.41345698
64Recurrent gram-negative bacterial infections (HP:0005420)2.40940496
65Ragged-red muscle fibers (HP:0003200)2.40750613
66Skin tags (HP:0010609)2.40607149
67Glioma (HP:0009733)2.39972142
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.39945328
69Renal duplication (HP:0000075)2.38420847
70Gastrointestinal stroma tumor (HP:0100723)2.38285351
71Aplasia/hypoplasia of the humerus (HP:0006507)2.37705185
72Tetraplegia (HP:0002445)2.33862223
73Abnormality of chromosome segregation (HP:0002916)2.32631229
74Thin bony cortex (HP:0002753)2.32393322
75Hemorrhage of the eye (HP:0011885)2.32012027
76Hyperinsulinemic hypoglycemia (HP:0000825)2.31776860
77Periauricular skin pits (HP:0100277)2.31395340
78Preauricular pit (HP:0004467)2.31395340
79Nasal polyposis (HP:0100582)2.31055656
80Pendular nystagmus (HP:0012043)2.30368477
81Chronic mucocutaneous candidiasis (HP:0002728)2.29841387
82Recurrent cutaneous fungal infections (HP:0011370)2.29841387
83Emphysema (HP:0002097)2.29795237
84Dysostosis multiplex (HP:0000943)2.29786974
85Prolonged bleeding time (HP:0003010)2.29082021
86Hypoplasia of the fovea (HP:0007750)2.28941933
87Aplasia/Hypoplasia of the fovea (HP:0008060)2.28941933
88Embryonal renal neoplasm (HP:0011794)2.28257506
89Abnormality of the musculature of the hand (HP:0001421)2.27200872
90Achilles tendon contracture (HP:0001771)2.26142698
91Shawl scrotum (HP:0000049)2.25218566
92Abnormality of T cell number (HP:0011839)2.24109961
93Pseudobulbar signs (HP:0002200)2.23886553
94Agammaglobulinemia (HP:0004432)2.23237955
95Hypochromic anemia (HP:0001931)2.21381755
96Autoimmune thrombocytopenia (HP:0001973)2.20591193
97Recurrent skin infections (HP:0001581)2.19983285
98Obstructive lung disease (HP:0006536)2.19797637
99Chronic obstructive pulmonary disease (HP:0006510)2.19797637
100Slow saccadic eye movements (HP:0000514)2.17777234
101Segmental peripheral demyelination/remyelination (HP:0003481)2.16378984
102Hypopigmentation of the fundus (HP:0007894)2.16243627
103Vaginal fistula (HP:0004320)2.14370842
104Stomatitis (HP:0010280)2.14348830
105Partial duplication of thumb phalanx (HP:0009944)2.11528220
106Chest pain (HP:0100749)2.10948097
107Interstitial pulmonary disease (HP:0006530)2.10548288
108Pulmonary infiltrates (HP:0002113)2.09651201
109Dyschromatopsia (HP:0007641)2.08691336
110Abnormality of the nasal mucosa (HP:0000433)2.08179712
111Malignant neoplasm of the central nervous system (HP:0100836)2.07909608
112Encephalitis (HP:0002383)2.05231188
113Skin pits (HP:0100276)2.03833445
114Abnormal cartilage morphology (HP:0002763)2.03795222
115Abnormality of small intestinal villus morphology (HP:0011472)2.03755795
116Villous atrophy (HP:0011473)2.03755795
117Cheilitis (HP:0100825)2.03560393
118EMG: neuropathic changes (HP:0003445)2.02554254
119Exercise-induced myalgia (HP:0003738)2.02272151
120Abnormality of the pubic bones (HP:0003172)2.01873110
121Supernumerary ribs (HP:0005815)2.01398535
122Malnutrition (HP:0004395)2.00226569
123Verrucae (HP:0200043)1.98920378
124Papilloma (HP:0012740)1.98920378
125Amblyopia (HP:0000646)1.98691114
126Easy fatigability (HP:0003388)1.98366453
127Abnormality of the distal phalanx of the thumb (HP:0009617)1.97931292
128Hemoptysis (HP:0002105)1.97796437
129Mucopolysacchariduria (HP:0008155)1.96488674
130Urinary glycosaminoglycan excretion (HP:0003541)1.96488674
131Centrally nucleated skeletal muscle fibers (HP:0003687)1.96179353
132Abnormality of the Achilles tendon (HP:0005109)1.96143396
133Vertebral fusion (HP:0002948)1.95795752
134Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95519623
135Ulnar bowing (HP:0003031)1.91547752
136Abnormality of T cells (HP:0002843)1.91043332
137Keratoconjunctivitis sicca (HP:0001097)1.90875746
138Dislocated radial head (HP:0003083)1.90328471
139Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90193441
140Onion bulb formation (HP:0003383)1.89844743
141Restrictive lung disease (HP:0002091)1.89493466
142Mildly elevated creatine phosphokinase (HP:0008180)1.89219672
143Annular pancreas (HP:0001734)1.88527105
144Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88001471
145Abnormality of polysaccharide metabolism (HP:0011012)1.88001471
146Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88001471
147Distal lower limb amyotrophy (HP:0008944)1.87202875
148Supernumerary nipples (HP:0002558)1.87143485
149Anomalous pulmonary venous return (HP:0010772)1.87010577
150Epistaxis (HP:0000421)1.86282706
151Absent frontal sinuses (HP:0002688)1.86139749
152Uterine leiomyosarcoma (HP:0002891)1.85859116
153Leiomyosarcoma (HP:0100243)1.85859116
154Flat acetabular roof (HP:0003180)1.85086885
155Aneurysm (HP:0002617)1.84984576
156Upper motor neuron abnormality (HP:0002127)1.84447344
157Asymmetric septal hypertrophy (HP:0001670)1.84309798
158Recurrent bronchitis (HP:0002837)1.84179649
159Systemic lupus erythematosus (HP:0002725)1.83859424
160Febrile seizures (HP:0002373)1.83242165
161Polygenic inheritance (HP:0010982)1.82991801
162Heterotopia (HP:0002282)1.82355317
163Seborrheic dermatitis (HP:0001051)1.80780445
164Neoplasm of the oral cavity (HP:0100649)1.80768844
165Abnormality of the radial head (HP:0003995)1.80182531
166Ureteral stenosis (HP:0000071)1.79999068
167Sensory axonal neuropathy (HP:0003390)1.79961504
168Granulocytopenia (HP:0001913)1.79799630
169Hemiparesis (HP:0001269)1.79114118
170Progressive muscle weakness (HP:0003323)1.78689999
171Hyperventilation (HP:0002883)1.78181998
172Partial duplication of the phalanx of hand (HP:0009999)1.78118302
173Lymphopenia (HP:0001888)1.77923602
174Combined immunodeficiency (HP:0005387)1.77798881
175Neuroectodermal neoplasm (HP:0030061)1.76794285
176Neuroepithelial neoplasm (HP:0030063)1.76794285
177Nervous tissue neoplasm (HP:0030060)1.76794285
178Supranuclear gaze palsy (HP:0000605)1.76774631
179Short 5th finger (HP:0009237)1.76223992
180Viral hepatitis (HP:0006562)1.74842981
181Neuronal loss in central nervous system (HP:0002529)1.74723150
182Bifid tongue (HP:0010297)1.74630996
183Adenoma sebaceum (HP:0009720)1.74422813
184Angiofibromas (HP:0010615)1.74422813
185Trismus (HP:0000211)1.74383633
186Hyperacusis (HP:0010780)1.74284319
187Abnormality of binocular vision (HP:0011514)1.73127329
188Diplopia (HP:0000651)1.73127329
189Autoimmune hemolytic anemia (HP:0001890)1.71985319
190Pulmonary embolism (HP:0002204)1.71706891
191Spastic tetraparesis (HP:0001285)1.71070002
192Lip pit (HP:0100267)1.70852395
193Dysmetric saccades (HP:0000641)1.70490262
194Increased cerebral lipofuscin (HP:0011813)1.70426396
195Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.70394588
196Deep venous thrombosis (HP:0002625)1.68702841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.86650898
2GRK53.93556314
3ERN13.67064088
4GRK63.58161085
5TYRO33.18229514
6GRK12.48878671
7RIPK42.44643544
8CSF1R2.26857890
9TGFBR22.20352567
10WNK12.15730124
11MAPK72.02567556
12STK101.97111775
13MAP3K101.92292277
14ZAP701.79129844
15ADRBK21.74320289
16MATK1.63596924
17MARK21.63330096
18FGFR31.61126074
19SMG11.58596630
20MAP3K141.56712519
21GRK71.56099855
22RIPK11.52842297
23MAP3K91.51792794
24ALK1.50903302
25CAMK41.50348849
26SIK21.47594838
27BLK1.46581163
28NTRK11.43602011
29MAP3K71.39990766
30IRAK31.39096017
31MAP2K31.37981831
32TRIB31.37537419
33TTK1.34635963
34TXK1.34060805
35HIPK21.32960292
36FES1.32784555
37IRAK41.31818796
38MOS1.30141085
39BTK1.29138477
40SIK31.25937233
41CAMKK11.24428792
42IKBKE1.19680398
43TBK11.19494095
44MAP3K31.18490106
45ICK1.15941604
46PRKG21.08632280
47CSK1.06250335
48MAP4K11.03548929
49TAOK10.99427037
50MAP2K40.94864557
51SYK0.93804765
52PDGFRA0.93605322
53MAP3K10.91480135
54STK380.88005611
55LCK0.87619415
56MTOR0.85600386
57PTK60.84105101
58TTN0.83275022
59MAP3K110.83160782
60MAPK110.82378330
61PAK40.81823438
62CDK70.81467038
63BMX0.80092339
64PAK60.79229582
65PDPK10.78675148
66PRKD20.76013504
67ITK0.73226200
68PRKCH0.72304985
69RET0.71098141
70SIK10.70519741
71PRKD30.69581458
72RPS6KC10.69501098
73RPS6KL10.69501098
74MAPK120.68778106
75EPHA20.67219497
76TAOK20.66983988
77AKT30.66414856
78NTRK20.64033375
79MST1R0.63688668
80PKN20.60451302
81LYN0.60275869
82NLK0.59337153
83FGR0.58785652
84EPHA40.57909852
85ADRBK10.57866873
86MAP3K20.57833285
87KIT0.57747682
88CHEK10.57514404
89RPS6KA60.57176110
90AKT20.56108132
91BRD40.55974086
92MARK30.54247439
93RPS6KA20.53994209
94EEF2K0.53223219
95PRPF4B0.53029584
96TAOK30.52965364
97MAP3K130.52864589
98CHEK20.51175719
99MELK0.48475605
100HCK0.48148308
101IRAK20.48134481
102MAP3K60.47881510
103MAPK100.47696244
104CAMK1D0.46836761
105EPHA30.46043102
106JAK10.45460461
107JAK30.45392613
108PTK20.44216986
109CDC42BPA0.44169479
110CHUK0.43924568
111FGFR40.43908406
112IKBKB0.43456477
113DDR20.43241505
114FYN0.42019810
115IRAK10.41998169
116PDK10.41852975
117PRKCQ0.41535849
118TRPM70.40676534
119CDK40.40615741
120JAK20.40548570
121CAMK1G0.40360829
122NTRK30.40295693
123EPHB10.39605371
124CDK20.39496982
125DMPK0.39459945
126KSR20.37322875
127PDGFRB0.37303658
128TNK20.35633665
129DAPK20.35118059
130INSR0.35102259
131PRKAA10.34259304
132RPS6KA30.34228231
133STK110.33070198
134TYK20.32069765
135GSK3B0.30967936
136MAP2K60.30925736
137NEK20.30296154
138LATS20.29987462
139IGF1R0.28564705
140CSNK1E0.27637628
141ERBB20.27585249
142SGK30.27078698
143MAPK10.26933188
144PRKD10.26021566
145MAPK140.25822529

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.73023576
2Vitamin B6 metabolism_Homo sapiens_hsa007502.34837946
3mTOR signaling pathway_Homo sapiens_hsa041502.23341420
4Fructose and mannose metabolism_Homo sapiens_hsa000512.11781524
5Other glycan degradation_Homo sapiens_hsa005111.96811309
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.71678020
7Graft-versus-host disease_Homo sapiens_hsa053321.65652502
8Allograft rejection_Homo sapiens_hsa053301.63733998
9Autoimmune thyroid disease_Homo sapiens_hsa053201.55336634
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53720815
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50531024
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49848832
13Phospholipase D signaling pathway_Homo sapiens_hsa040721.48434712
14Phosphatidylinositol signaling system_Homo sapiens_hsa040701.48268933
15Staphylococcus aureus infection_Homo sapiens_hsa051501.46923409
16Thyroid hormone signaling pathway_Homo sapiens_hsa049191.46905877
17Measles_Homo sapiens_hsa051621.40158352
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37863204
19TNF signaling pathway_Homo sapiens_hsa046681.35775269
20T cell receptor signaling pathway_Homo sapiens_hsa046601.33875784
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29910124
22Acute myeloid leukemia_Homo sapiens_hsa052211.28581429
23Inositol phosphate metabolism_Homo sapiens_hsa005621.28523922
24Influenza A_Homo sapiens_hsa051641.25172463
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23681699
26VEGF signaling pathway_Homo sapiens_hsa043701.23511938
27Tuberculosis_Homo sapiens_hsa051521.22617919
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21016586
29B cell receptor signaling pathway_Homo sapiens_hsa046621.18520400
30Choline metabolism in cancer_Homo sapiens_hsa052311.17592081
31Non-small cell lung cancer_Homo sapiens_hsa052231.17305358
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16435582
33Hepatitis B_Homo sapiens_hsa051611.15657778
34Galactose metabolism_Homo sapiens_hsa000521.15408913
35Dorso-ventral axis formation_Homo sapiens_hsa043201.14376002
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.14119524
37Hepatitis C_Homo sapiens_hsa051601.13602488
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09981363
39Dilated cardiomyopathy_Homo sapiens_hsa054141.09951016
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08915920
41Long-term potentiation_Homo sapiens_hsa047201.08905870
42Type I diabetes mellitus_Homo sapiens_hsa049401.08365091
43Glutamatergic synapse_Homo sapiens_hsa047241.07874065
44Notch signaling pathway_Homo sapiens_hsa043301.06473710
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.05844232
46Rap1 signaling pathway_Homo sapiens_hsa040151.04833962
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02932181
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02787016
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.01089710
50Primary immunodeficiency_Homo sapiens_hsa053400.98217656
51Thyroid cancer_Homo sapiens_hsa052160.97702419
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96913511
53GnRH signaling pathway_Homo sapiens_hsa049120.96720407
54Platelet activation_Homo sapiens_hsa046110.96230784
55Oxytocin signaling pathway_Homo sapiens_hsa049210.95494873
56Hematopoietic cell lineage_Homo sapiens_hsa046400.95111038
57Antigen processing and presentation_Homo sapiens_hsa046120.94974407
58GABAergic synapse_Homo sapiens_hsa047270.94619874
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94589473
60mRNA surveillance pathway_Homo sapiens_hsa030150.93296541
61Malaria_Homo sapiens_hsa051440.93005460
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91832407
63Proteoglycans in cancer_Homo sapiens_hsa052050.89769145
64Phototransduction_Homo sapiens_hsa047440.89435297
65MicroRNAs in cancer_Homo sapiens_hsa052060.89434609
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87367412
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.86798948
68Lysine degradation_Homo sapiens_hsa003100.86414385
69Insulin signaling pathway_Homo sapiens_hsa049100.85234450
70MAPK signaling pathway_Homo sapiens_hsa040100.85215049
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85076864
72cAMP signaling pathway_Homo sapiens_hsa040240.84247391
73Pertussis_Homo sapiens_hsa051330.84203154
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82884133
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82680690
76Insulin resistance_Homo sapiens_hsa049310.82480285
77Estrogen signaling pathway_Homo sapiens_hsa049150.81379126
78Chronic myeloid leukemia_Homo sapiens_hsa052200.80932983
79Salivary secretion_Homo sapiens_hsa049700.80417886
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.80200707
81Type II diabetes mellitus_Homo sapiens_hsa049300.80164289
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79444613
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.79433271
84Olfactory transduction_Homo sapiens_hsa047400.79338121
85Pancreatic cancer_Homo sapiens_hsa052120.78661962
86ErbB signaling pathway_Homo sapiens_hsa040120.78286255
87FoxO signaling pathway_Homo sapiens_hsa040680.78249866
88Pathways in cancer_Homo sapiens_hsa052000.77661471
89Glioma_Homo sapiens_hsa052140.77584694
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76366548
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74859260
92Asthma_Homo sapiens_hsa053100.74567982
93Renin secretion_Homo sapiens_hsa049240.72271483
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72005320
95Prostate cancer_Homo sapiens_hsa052150.71800278
96Endometrial cancer_Homo sapiens_hsa052130.71465015
97AMPK signaling pathway_Homo sapiens_hsa041520.71392104
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.71037088
99Renal cell carcinoma_Homo sapiens_hsa052110.69856837
100Chemokine signaling pathway_Homo sapiens_hsa040620.69695517
101Calcium signaling pathway_Homo sapiens_hsa040200.69091459
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68622647
103Endocytosis_Homo sapiens_hsa041440.68190196
104Adherens junction_Homo sapiens_hsa045200.67935375
105Colorectal cancer_Homo sapiens_hsa052100.67496297
106Long-term depression_Homo sapiens_hsa047300.67356158
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.66821469
108Small cell lung cancer_Homo sapiens_hsa052220.65480606
109African trypanosomiasis_Homo sapiens_hsa051430.65262982
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64683801
111Nitrogen metabolism_Homo sapiens_hsa009100.63969017
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.63589117
113Prolactin signaling pathway_Homo sapiens_hsa049170.62991993
114Gastric acid secretion_Homo sapiens_hsa049710.62224168
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61714536
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.61470281
117Viral myocarditis_Homo sapiens_hsa054160.60947452
118Apoptosis_Homo sapiens_hsa042100.60799255
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60306106
120Toxoplasmosis_Homo sapiens_hsa051450.59938301
121Ras signaling pathway_Homo sapiens_hsa040140.59431841
122Amoebiasis_Homo sapiens_hsa051460.58790222
123Focal adhesion_Homo sapiens_hsa045100.58715232
124Prion diseases_Homo sapiens_hsa050200.58488659
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58361782
126Ovarian steroidogenesis_Homo sapiens_hsa049130.58096542
127Leishmaniasis_Homo sapiens_hsa051400.57663280
128Osteoclast differentiation_Homo sapiens_hsa043800.57502207
129Taste transduction_Homo sapiens_hsa047420.56303538
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.55817417
131HTLV-I infection_Homo sapiens_hsa051660.55808156
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55734783
133HIF-1 signaling pathway_Homo sapiens_hsa040660.55118675
134Herpes simplex infection_Homo sapiens_hsa051680.54512691
135Hippo signaling pathway_Homo sapiens_hsa043900.54389778
136Epstein-Barr virus infection_Homo sapiens_hsa051690.54143639
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.53728282
138Bladder cancer_Homo sapiens_hsa052190.52439387
139Viral carcinogenesis_Homo sapiens_hsa052030.52431566
140Lysosome_Homo sapiens_hsa041420.50355175

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