MLN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to stimulus involved in regulation of muscle adaptation (GO:0014874)9.08096972
2vitamin D metabolic process (GO:0042359)8.92717599
3trivalent inorganic anion homeostasis (GO:0072506)8.59173625
4phosphate ion homeostasis (GO:0055062)8.59173625
5cellular anion homeostasis (GO:0030002)8.51685561
6behavioral response to nicotine (GO:0035095)7.62963691
7tooth mineralization (GO:0034505)6.63989733
8phosphorelay signal transduction system (GO:0000160)6.39687072
9positive regulation of fatty acid oxidation (GO:0046321)6.19277428
10L-serine metabolic process (GO:0006563)6.16472035
11positive regulation of fatty acid beta-oxidation (GO:0032000)5.93993600
12negative regulation of response to food (GO:0032096)5.59890295
13negative regulation of appetite (GO:0032099)5.59890295
14chaperone-mediated protein complex assembly (GO:0051131)5.32223054
15response to pheromone (GO:0019236)5.02780360
16steroid catabolic process (GO:0006706)4.83404257
17negative regulation of bone mineralization (GO:0030502)4.78190361
18acrosome reaction (GO:0007340)4.77260869
19otic vesicle formation (GO:0030916)4.73784802
20proline biosynthetic process (GO:0006561)4.64262062
21high-density lipoprotein particle remodeling (GO:0034375)4.54366916
22phospholipid efflux (GO:0033700)4.42935868
23oligosaccharide catabolic process (GO:0009313)4.40525819
24response to follicle-stimulating hormone (GO:0032354)4.40274792
25water-soluble vitamin biosynthetic process (GO:0042364)4.37939624
26regulation of triglyceride catabolic process (GO:0010896)4.37615229
27intracellular protein transmembrane import (GO:0044743)4.36454791
28glucosamine-containing compound catabolic process (GO:1901072)4.35747387
29pseudouridine synthesis (GO:0001522)4.21112002
30negative regulation of biomineral tissue development (GO:0070168)4.11942957
31cellular response to oxygen radical (GO:0071450)4.11915743
32removal of superoxide radicals (GO:0019430)4.11915743
33cellular response to superoxide (GO:0071451)4.11915743
34regulation of chromatin binding (GO:0035561)4.07983617
35positive regulation of vascular permeability (GO:0043117)4.03035558
36reverse cholesterol transport (GO:0043691)3.96687891
37positive regulation of lipid catabolic process (GO:0050996)3.95196395
38proline metabolic process (GO:0006560)3.93177847
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.92914400
40negative regulation of transcription regulatory region DNA binding (GO:2000678)3.87315753
41fat-soluble vitamin metabolic process (GO:0006775)3.86182574
42positive regulation of gluconeogenesis (GO:0045722)3.85052967
43serine family amino acid biosynthetic process (GO:0009070)3.77314306
44regulation of sequestering of triglyceride (GO:0010889)3.77064892
45cellular response to zinc ion (GO:0071294)3.72898666
46somite development (GO:0061053)3.68241843
47negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.65531260
48intracellular protein transmembrane transport (GO:0065002)3.63512422
49regulation of appetite (GO:0032098)3.62473699
50negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.59208428
51regulation of response to food (GO:0032095)3.57742216
52regulation of double-strand break repair via homologous recombination (GO:0010569)3.57533518
53thalamus development (GO:0021794)3.47902273
54glycine transport (GO:0015816)3.47696024
55membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.46901535
56postsynaptic membrane organization (GO:0001941)3.34493706
57glutamine metabolic process (GO:0006541)3.26973872
58regulation of cholesterol esterification (GO:0010872)3.22673317
59iron-sulfur cluster assembly (GO:0016226)3.21635165
60metallo-sulfur cluster assembly (GO:0031163)3.21635165
61lysosome localization (GO:0032418)3.19998219
62membrane repolarization during action potential (GO:0086011)3.18288427
63plasma lipoprotein particle assembly (GO:0034377)3.12465065
64forebrain neuron differentiation (GO:0021879)3.04625628
65positive regulation of fatty acid metabolic process (GO:0045923)3.04340925
66negative regulation of potassium ion transmembrane transport (GO:1901380)3.03623680
67response to oxygen radical (GO:0000305)3.03517273
68glutamine family amino acid biosynthetic process (GO:0009084)3.00844655
69protein transmembrane transport (GO:0071806)2.96719146
70homocysteine metabolic process (GO:0050667)2.94631270
71regulation of fatty acid beta-oxidation (GO:0031998)2.94180714
72regulation of cholesterol storage (GO:0010885)2.91978677
73response to superoxide (GO:0000303)2.90518759
74cell fate commitment involved in formation of primary germ layer (GO:0060795)2.88973701
75positive regulation of dendrite morphogenesis (GO:0050775)2.88890481
76establishment of tissue polarity (GO:0007164)2.85450731
77establishment of planar polarity (GO:0001736)2.85450731
78very-low-density lipoprotein particle assembly (GO:0034379)2.81025936
79anion homeostasis (GO:0055081)2.80920828
80neurotransmitter-gated ion channel clustering (GO:0072578)2.77695063
81histone H4-K12 acetylation (GO:0043983)2.77665814
82negative regulation of lipase activity (GO:0060192)2.76670324
83cellular biogenic amine catabolic process (GO:0042402)2.73670646
84amine catabolic process (GO:0009310)2.73670646
85negative regulation of sterol transport (GO:0032372)2.70515637
86negative regulation of cholesterol transport (GO:0032375)2.70515637
87plasma lipoprotein particle remodeling (GO:0034369)2.69053550
88protein-lipid complex remodeling (GO:0034368)2.69053550
89macromolecular complex remodeling (GO:0034367)2.69053550
90lysine metabolic process (GO:0006553)2.68852501
91lysine catabolic process (GO:0006554)2.68852501
92negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.66721203
93protein-lipid complex assembly (GO:0065005)2.63553600
94forebrain neuron development (GO:0021884)2.62607232
95regulation of hydrogen peroxide-induced cell death (GO:1903205)2.62246553
96cholesterol efflux (GO:0033344)2.54946925
97synaptonemal complex assembly (GO:0007130)2.54407092
98fat-soluble vitamin catabolic process (GO:0042363)11.8551088
99vitamin catabolic process (GO:0009111)11.8551088
100establishment of protein localization to mitochondrial membrane (GO:0090151)10.8129223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.07898397
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.74144196
3EZH2_22144423_ChIP-Seq_EOC_Human5.11166671
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.69697615
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.55483355
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.99250280
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.69662526
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.69287029
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58792496
10THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19574830
11* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.14637305
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.10192750
13POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.08799906
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05651743
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.02668669
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.00780594
17EST1_17652178_ChIP-ChIP_JURKAT_Human1.91097340
18YY1_21170310_ChIP-Seq_MESCs_Mouse1.88133217
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.83771012
20NANOG_21062744_ChIP-ChIP_HESCs_Human1.81818126
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.80128363
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74069040
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.73571345
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68996338
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.61259891
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57057324
27TTF2_22483619_ChIP-Seq_HELA_Human1.48977874
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43452627
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.40741215
30MYC_18940864_ChIP-ChIP_HL60_Human1.36032001
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35721018
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35118160
33ELK1_19687146_ChIP-ChIP_HELA_Human1.30426355
34FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.26774218
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26220276
36CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24965721
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24124344
38SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.23842357
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20736568
40ZNF274_21170338_ChIP-Seq_K562_Hela1.19929862
41SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.19149460
42NANOG_16153702_ChIP-ChIP_HESCs_Human1.18507517
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16710792
44CTCF_20526341_ChIP-Seq_ESCs_Human1.16560981
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12718346
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12718346
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10042621
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09597459
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09076631
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06933440
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.04291998
52CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01732807
53TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00818858
54DROSHA_22980978_ChIP-Seq_HELA_Human1.00811486
55FOXH1_21741376_ChIP-Seq_EPCs_Human1.00237103
56SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00209912
57* NCOR_22424771_ChIP-Seq_293T_Human0.99251854
58TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98514835
59TAF2_19829295_ChIP-Seq_ESCs_Human0.96300849
60* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95786838
61IRF1_19129219_ChIP-ChIP_H3396_Human0.95505541
62XRN2_22483619_ChIP-Seq_HELA_Human0.94300379
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94185485
64TET1_21451524_ChIP-Seq_MESCs_Mouse0.92681182
65TP63_17297297_ChIP-ChIP_HaCaT_Human0.92255632
66E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91245145
67* BCAT_22108803_ChIP-Seq_LS180_Human0.90298214
68FOXA1_25329375_ChIP-Seq_VCAP_Human0.90287739
69FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90287739
70RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89149622
71PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88278599
72NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87748097
73FOXH1_21741376_ChIP-Seq_ESCs_Human0.87664322
74GATA3_21878914_ChIP-Seq_MCF-7_Human0.87040868
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86786423
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86431713
77MYC_19030024_ChIP-ChIP_MESCs_Mouse0.86145689
78TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85886774
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85810575
80EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85707638
81GABP_19822575_ChIP-Seq_HepG2_Human0.85151000
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85111685
83MYC_18555785_ChIP-Seq_MESCs_Mouse0.82007806
84EZH2_27294783_Chip-Seq_ESCs_Mouse0.81912947
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81575504
86ERG_21242973_ChIP-ChIP_JURKAT_Human0.80650834
87NANOG_20526341_ChIP-Seq_ESCs_Human0.79953432
88MYC_19915707_ChIP-ChIP_AK7_Human0.79591544
89P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.79383769
90KDM5A_27292631_Chip-Seq_BREAST_Human0.78469211
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78335834
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.77695059
93KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.77484500
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76570142
95GATA3_21867929_ChIP-Seq_CD8_Mouse0.75447794
96TCF3_18692474_ChIP-Seq_MESCs_Mouse0.74480224
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.74147062
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74129271
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.74106811
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73698905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.69911638
2MP0002089_abnormal_postnatal_growth/wei5.14341110
3MP0003136_yellow_coat_color5.13846830
4MP0009840_abnormal_foam_cell4.20435473
5MP0002160_abnormal_reproductive_system3.96934095
6MP0001542_abnormal_bone_strength3.54921257
7MP0004019_abnormal_vitamin_homeostasis3.51718497
8MP0002653_abnormal_ependyma_morphology3.39384395
9MP0002638_abnormal_pupillary_reflex3.08260761
10MP0001853_heart_inflammation3.05788540
11MP0003221_abnormal_cardiomyocyte_apopto2.91538406
12MP0003646_muscle_fatigue2.87760167
13MP0005389_reproductive_system_phenotype2.77346294
14MP0000343_altered_response_to2.35039233
15MP0000372_irregular_coat_pigmentation2.14249092
16MP0002277_abnormal_respiratory_mucosa2.13659302
17MP0004130_abnormal_muscle_cell2.08564616
18MP0010234_abnormal_vibrissa_follicle1.87307247
19MP0005360_urolithiasis1.85785967
20MP0003878_abnormal_ear_physiology1.77034448
21MP0005377_hearing/vestibular/ear_phenot1.77034448
22MP0004142_abnormal_muscle_tone1.65505025
23MP0002090_abnormal_vision1.62605666
24MP0003938_abnormal_ear_development1.57942477
25MP0003806_abnormal_nucleotide_metabolis1.50566495
26MP0004233_abnormal_muscle_weight1.49283046
27MP0004858_abnormal_nervous_system1.49218420
28MP0004885_abnormal_endolymph1.47158202
29MP0001293_anophthalmia1.45802098
30MP0001485_abnormal_pinna_reflex1.45326337
31MP0000647_abnormal_sebaceous_gland1.36793784
32MP0005410_abnormal_fertilization1.31708763
33MP0003880_abnormal_central_pattern1.30406134
34MP0005551_abnormal_eye_electrophysiolog1.25856141
35MP0010030_abnormal_orbit_morphology1.21573243
36MP0000049_abnormal_middle_ear1.21245758
37MP0001486_abnormal_startle_reflex1.20790701
38MP0001765_abnormal_ion_homeostasis1.16095039
39MP0001177_atelectasis1.15679585
40MP0010329_abnormal_lipoprotein_level1.14694573
41MP0002697_abnormal_eye_size1.07611153
42MP0004270_analgesia1.06768390
43MP0002876_abnormal_thyroid_physiology1.05552608
44MP0002736_abnormal_nociception_after0.97558289
45MP0000467_abnormal_esophagus_morphology0.97246059
46MP0002210_abnormal_sex_determination0.95084846
47MP0001286_abnormal_eye_development0.94902205
48MP0000230_abnormal_systemic_arterial0.93674551
49MP0002751_abnormal_autonomic_nervous0.92189359
50MP0006072_abnormal_retinal_apoptosis0.90789966
51MP0002734_abnormal_mechanical_nocicepti0.89988296
52MP0001502_abnormal_circadian_rhythm0.88561654
53MP0001299_abnormal_eye_distance/0.88377565
54MP0002896_abnormal_bone_mineralization0.87990516
55MP0001905_abnormal_dopamine_level0.84539350
56MP0002102_abnormal_ear_morphology0.84486990
57MP0005058_abnormal_lysosome_morphology0.83377349
58MP0005332_abnormal_amino_acid0.82873305
59MP0000955_abnormal_spinal_cord0.82548420
60MP0003942_abnormal_urinary_system0.82513587
61MP0001666_abnormal_nutrient_absorption0.81817896
62MP0002249_abnormal_larynx_morphology0.81710456
63MP0004145_abnormal_muscle_electrophysio0.81347442
64MP0000566_synostosis0.79354420
65MP0000778_abnormal_nervous_system0.79243863
66MP0001919_abnormal_reproductive_system0.78462342
67MP0004185_abnormal_adipocyte_glucose0.78262852
68MP0002132_abnormal_respiratory_system0.77355996
69MP0002098_abnormal_vibrissa_morphology0.77215815
70MP0000653_abnormal_sex_gland0.76937581
71MP0002837_dystrophic_cardiac_calcinosis0.76936476
72MP0008789_abnormal_olfactory_epithelium0.76255296
73MP0003119_abnormal_digestive_system0.75400907
74MP0001663_abnormal_digestive_system0.72973090
75MP0001145_abnormal_male_reproductive0.72887076
76MP0000026_abnormal_inner_ear0.69156209
77MP0005075_abnormal_melanosome_morpholog0.68790112
78MP0002184_abnormal_innervation0.67023752
79MP0003011_delayed_dark_adaptation0.66638496
80MP0005499_abnormal_olfactory_system0.65595300
81MP0005394_taste/olfaction_phenotype0.65595300
82MP0005448_abnormal_energy_balance0.65340277
83MP0000631_abnormal_neuroendocrine_gland0.62746480
84MP0003718_maternal_effect0.61483219
85MP0003633_abnormal_nervous_system0.61328161
86MP0003953_abnormal_hormone_level0.60733920
87MP0004215_abnormal_myocardial_fiber0.59883469
88MP0002752_abnormal_somatic_nervous0.59876889
89MP0001963_abnormal_hearing_physiology0.59215445
90MP0005171_absent_coat_pigmentation0.56186079
91MP0002909_abnormal_adrenal_gland0.53703728
92MP0002152_abnormal_brain_morphology0.53660692
93MP0001929_abnormal_gametogenesis0.53525481
94MP0002063_abnormal_learning/memory/cond0.53194016
95MP0002109_abnormal_limb_morphology0.52933358
96MP0003186_abnormal_redox_activity0.51996873
97MP0002233_abnormal_nose_morphology0.51661033
98MP0005195_abnormal_posterior_eye0.51223812
99MP0002272_abnormal_nervous_system0.49660955
100MP0003632_abnormal_nervous_system0.49305005

Predicted human phenotypes

RankGene SetZ-score
1Osteomalacia (HP:0002749)9.48914831
2Vascular calcification (HP:0004934)8.23420741
3Cardiovascular calcification (HP:0011915)7.35132530
4Abnormality of renal resorption (HP:0011038)5.65363041
5Hyperphosphatemia (HP:0002905)5.39635594
6Septo-optic dysplasia (HP:0100842)5.33969179
7Cortical dysplasia (HP:0002539)4.93167511
8Abnormality of the pons (HP:0007361)4.75659172
9Cortical visual impairment (HP:0100704)4.72811295
10Abnormality of the dental root (HP:0006486)4.45107000
11Taurodontia (HP:0000679)4.45107000
12Abnormality of permanent molar morphology (HP:0011071)4.45107000
13Long foot (HP:0001833)4.38311115
14Abnormal urine phosphate concentration (HP:0012599)4.21854402
15Abnormality of molar (HP:0011077)4.15419552
16Abnormality of molar morphology (HP:0011070)4.15419552
17Hypoplasia of the pons (HP:0012110)4.11561393
18Abnormality of the dental pulp (HP:0006479)4.02745767
19Spinal canal stenosis (HP:0003416)3.92502780
20Partial duplication of thumb phalanx (HP:0009944)3.79124344
21Duplicated collecting system (HP:0000081)3.49258261
22Absent septum pellucidum (HP:0001331)3.48023785
23Reticulocytopenia (HP:0001896)3.38196144
24Abnormality of the renal collecting system (HP:0004742)3.30692796
25Duplication of thumb phalanx (HP:0009942)3.29074243
26Hypobetalipoproteinemia (HP:0003563)3.27399303
27Large hands (HP:0001176)3.26013508
28Premature skin wrinkling (HP:0100678)3.25216845
29Partial duplication of the phalanx of hand (HP:0009999)3.23311778
30Optic nerve hypoplasia (HP:0000609)3.00739269
31Maternal diabetes (HP:0009800)2.85221450
32Elevated alkaline phosphatase (HP:0003155)2.77479705
33Abnormality of the septum pellucidum (HP:0007375)2.76957589
34Rickets (HP:0002748)2.75078178
35Abnormality of renal excretion (HP:0011036)2.72227235
36Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.56769322
37Abnormality of alkaline phosphatase activity (HP:0004379)2.50666957
38Chondrocalcinosis (HP:0000934)2.48752073
39Abnormality of pyrimidine metabolism (HP:0004353)2.45040206
40Hepatocellular necrosis (HP:0001404)2.44489250
41Increased hepatocellular lipid droplets (HP:0006565)2.41926381
42Abnormal enzyme/coenzyme activity (HP:0012379)2.39761752
43Abnormality of Sharpey fibers (HP:0100685)2.39047015
44Lipid accumulation in hepatocytes (HP:0006561)2.38917166
45Increased intramyocellular lipid droplets (HP:0012240)2.38608311
46Abnormality of cells of the erythroid lineage (HP:0012130)2.36909743
47Generalized muscle weakness (HP:0003324)2.36472245
48Delayed CNS myelination (HP:0002188)2.32693204
49Large for gestational age (HP:0001520)2.30242478
50Mitochondrial inheritance (HP:0001427)2.29291795
51Hyperglycinemia (HP:0002154)2.28334955
52Hepatic necrosis (HP:0002605)2.25440172
53Abnormality of DNA repair (HP:0003254)2.23741959
54Increased muscle lipid content (HP:0009058)2.20853245
55Flat capital femoral epiphysis (HP:0003370)2.18194238
56Hypoplasia of dental enamel (HP:0006297)2.15919888
57Anencephaly (HP:0002323)2.15835802
58Abnormality of serine family amino acid metabolism (HP:0010894)2.15024150
59Abnormality of glycine metabolism (HP:0010895)2.15024150
60Hypsarrhythmia (HP:0002521)2.14608004
61Lower limb hyperreflexia (HP:0002395)2.14369598
62Abnormal number of erythroid precursors (HP:0012131)2.13232858
63Hyperglycinuria (HP:0003108)2.12100214
64Redundant skin (HP:0001582)2.11880291
65Epileptiform EEG discharges (HP:0011182)2.11145016
66Abnormality of midbrain morphology (HP:0002418)2.11022479
67Molar tooth sign on MRI (HP:0002419)2.11022479
68Muscular hypotonia of the trunk (HP:0008936)2.10252188
69Abnormal rod and cone electroretinograms (HP:0008323)2.05361547
70Megalencephaly (HP:0001355)2.01292216
71EEG with generalized epileptiform discharges (HP:0011198)2.00753321
72Microretrognathia (HP:0000308)1.97726110
73Rectovaginal fistula (HP:0000143)1.96222401
74Rectal fistula (HP:0100590)1.96222401
75Absent/shortened dynein arms (HP:0200106)1.95198935
76Dynein arm defect of respiratory motile cilia (HP:0012255)1.95198935
77Broad foot (HP:0001769)1.93183552
78Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.93091869
79Hypophosphatemia (HP:0002148)1.88045477
80Acute encephalopathy (HP:0006846)1.87272946
81Muscle fiber atrophy (HP:0100295)1.86133190
82Coronal craniosynostosis (HP:0004440)1.85169717
83Polyphagia (HP:0002591)1.84569759
84Optic disc pallor (HP:0000543)1.80486744
85Generalized aminoaciduria (HP:0002909)1.80117529
86Vaginal fistula (HP:0004320)1.79188250
87Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77523979
88Severe visual impairment (HP:0001141)1.75960048
89Renal Fanconi syndrome (HP:0001994)1.75343933
90True hermaphroditism (HP:0010459)1.73853261
91Abnormality of the epiphysis of the femoral head (HP:0010574)1.72611598
92Decreased activity of mitochondrial respiratory chain (HP:0008972)1.71520741
93Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.71520741
94Acute necrotizing encephalopathy (HP:0006965)1.71126648
95Hypoplasia of the fovea (HP:0007750)1.68543843
96Aplasia/Hypoplasia of the fovea (HP:0008060)1.68543843
97Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68206946
98Pancreatic cysts (HP:0001737)1.65856894
99Abnormal mitochondria in muscle tissue (HP:0008316)1.63955259
100Delayed myelination (HP:0012448)1.61900742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.55553878
2STK396.85353307
3EEF2K3.77160050
4PRKD33.27557469
5MUSK2.83694030
6MAPKAPK32.73422288
7BMPR1B2.68336354
8WNK12.62406414
9PIK3CG2.40318036
10RPS6KA42.36805913
11STK162.30459638
12MAP2K71.95843100
13PLK21.90582342
14MAP3K41.86382832
15PBK1.78041888
16MKNK21.77878965
17STK38L1.76678219
18BCKDK1.75118725
19MAP2K41.44761726
20NTRK21.43890377
21CDK81.39071921
22ABL21.36197219
23TRIB31.33814802
24EPHA41.32364807
25MAP3K101.29607596
26RPS6KA21.27292287
27PINK11.26844893
28TAOK31.23915130
29TGFBR11.20954407
30IRAK41.20952240
31FGFR21.13368288
32PRKD21.11579617
33MOS1.05764878
34MAPKAPK50.98641901
35GRK10.96461927
36RPS6KA60.94015492
37RPS6KC10.93416859
38RPS6KL10.93416859
39RPS6KB20.90713113
40ALK0.87501775
41MKNK10.83084554
42MAPK110.80349926
43TYRO30.75329830
44PRKG20.73881264
45STK240.65274766
46TESK20.64288235
47MAPK40.63809103
48PDK20.63344515
49GRK50.62256626
50LMTK20.59110811
51CASK0.56035424
52PAK60.53468954
53TAF10.53403087
54TRPM70.52247482
55MAPK130.50846862
56FRK0.50432133
57DYRK1A0.45813427
58PRKCQ0.44010128
59CDK140.43404186
60INSR0.42065741
61AKT20.40574294
62FGFR10.39946225
63PTK2B0.37231198
64CSNK1A10.37091861
65PLK30.36930088
66WNK30.36371041
67MAP2K10.35063686
68DYRK30.34536678
69CAMK1D0.33393636
70CSNK2A10.31832764
71RPS6KA10.30125483
72PDPK10.30070916
73PRKCE0.29517560
74MARK30.28319450
75MAPK120.26869272
76FYN0.25834053
77PRKCZ0.23859859
78UHMK10.23844058
79RPS6KA50.23358340
80PRKCG0.22646097
81MAP2K60.20961872
82PASK0.20184282
83MAP3K90.18441896
84MAPK90.17950120
85MAP3K60.17850416
86CDK90.16409705
87SMG10.16293605
88PRKACG0.15948421
89EPHB20.13255405
90CDK50.13206757
91TNIK0.13087246
92FES0.12790283
93RPS6KB10.12776128
94MAPK70.12700483
95AURKA0.12580602
96MAPKAPK20.12410559
97CDK150.12002622
98INSRR0.11745275
99CHEK10.11667144
100MAP4K20.10951504

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004504.14923786
2Oxidative phosphorylation_Homo sapiens_hsa001902.96927102
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.76839906
4Arginine and proline metabolism_Homo sapiens_hsa003302.67851500
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.67443501
6Parkinsons disease_Homo sapiens_hsa050122.58867824
7Vitamin digestion and absorption_Homo sapiens_hsa049772.55815388
8Biosynthesis of amino acids_Homo sapiens_hsa012302.39961739
9Vitamin B6 metabolism_Homo sapiens_hsa007502.31340315
10beta-Alanine metabolism_Homo sapiens_hsa004102.27451056
11Ribosome_Homo sapiens_hsa030102.18782418
12Huntingtons disease_Homo sapiens_hsa050162.13797462
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.12204298
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.99386777
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.95149298
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.89616520
17Alzheimers disease_Homo sapiens_hsa050101.78564932
18Propanoate metabolism_Homo sapiens_hsa006401.73702000
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71087965
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.68401290
21Base excision repair_Homo sapiens_hsa034101.67864465
22Galactose metabolism_Homo sapiens_hsa000521.67175718
23Tryptophan metabolism_Homo sapiens_hsa003801.63688256
24One carbon pool by folate_Homo sapiens_hsa006701.59362310
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.55775936
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53082392
27Basal cell carcinoma_Homo sapiens_hsa052171.45465135
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43712481
29PPAR signaling pathway_Homo sapiens_hsa033201.39233000
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.37037286
31Hedgehog signaling pathway_Homo sapiens_hsa043401.35139670
32Melanoma_Homo sapiens_hsa052181.33599550
33Ether lipid metabolism_Homo sapiens_hsa005651.33115437
34Proteasome_Homo sapiens_hsa030501.25510004
35Linoleic acid metabolism_Homo sapiens_hsa005911.22815594
36Arginine biosynthesis_Homo sapiens_hsa002201.22643466
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22220458
38Pyruvate metabolism_Homo sapiens_hsa006201.21261521
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21002318
40Histidine metabolism_Homo sapiens_hsa003401.17844754
41Folate biosynthesis_Homo sapiens_hsa007901.13266706
42Fat digestion and absorption_Homo sapiens_hsa049751.12134487
43Glycerolipid metabolism_Homo sapiens_hsa005611.06874954
44Fanconi anemia pathway_Homo sapiens_hsa034601.06463715
45Butanoate metabolism_Homo sapiens_hsa006501.03801178
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03588214
47Notch signaling pathway_Homo sapiens_hsa043301.01840800
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98961257
49Retinol metabolism_Homo sapiens_hsa008300.96682494
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96410164
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93504460
52Nucleotide excision repair_Homo sapiens_hsa034200.89999883
53Chemical carcinogenesis_Homo sapiens_hsa052040.89234123
54Carbon metabolism_Homo sapiens_hsa012000.88303266
55Basal transcription factors_Homo sapiens_hsa030220.88015716
56Pyrimidine metabolism_Homo sapiens_hsa002400.87389422
57Fatty acid degradation_Homo sapiens_hsa000710.87147524
58Fructose and mannose metabolism_Homo sapiens_hsa000510.86418819
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86261021
60Mineral absorption_Homo sapiens_hsa049780.85131444
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84700562
62Metabolic pathways_Homo sapiens_hsa011000.84699710
63RNA polymerase_Homo sapiens_hsa030200.84422211
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.82064749
65Lysine degradation_Homo sapiens_hsa003100.74522127
66Cardiac muscle contraction_Homo sapiens_hsa042600.74130515
67Phototransduction_Homo sapiens_hsa047440.73685340
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73528258
69Homologous recombination_Homo sapiens_hsa034400.70856706
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69616379
71Fatty acid elongation_Homo sapiens_hsa000620.67883439
72Glucagon signaling pathway_Homo sapiens_hsa049220.67509492
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63819067
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.61880955
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61317930
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56886004
77Hippo signaling pathway_Homo sapiens_hsa043900.56634883
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51445691
79Type II diabetes mellitus_Homo sapiens_hsa049300.50995209
80Taste transduction_Homo sapiens_hsa047420.48024765
81Arachidonic acid metabolism_Homo sapiens_hsa005900.46103947
82DNA replication_Homo sapiens_hsa030300.43643468
83Nicotine addiction_Homo sapiens_hsa050330.41542517
84Ras signaling pathway_Homo sapiens_hsa040140.41261427
85Tyrosine metabolism_Homo sapiens_hsa003500.41069359
86Glutathione metabolism_Homo sapiens_hsa004800.39810414
87Purine metabolism_Homo sapiens_hsa002300.39202583
88Renin-angiotensin system_Homo sapiens_hsa046140.35707401
89Olfactory transduction_Homo sapiens_hsa047400.32968475
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.32863875
91ABC transporters_Homo sapiens_hsa020100.31354509
92Nitrogen metabolism_Homo sapiens_hsa009100.31307442
93Starch and sucrose metabolism_Homo sapiens_hsa005000.30458942
94Regulation of autophagy_Homo sapiens_hsa041400.29437950
95AMPK signaling pathway_Homo sapiens_hsa041520.28393581
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.28074360
97Complement and coagulation cascades_Homo sapiens_hsa046100.24994350
98Sulfur metabolism_Homo sapiens_hsa009200.23646677
99Circadian rhythm_Homo sapiens_hsa047100.23569273
100Insulin resistance_Homo sapiens_hsa049310.22716489

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