MLNR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1toxin transport (GO:1901998)9.94537387
2positive regulation of digestive system process (GO:0060456)9.75891913
3heart trabecula formation (GO:0060347)8.55921383
4heparan sulfate proteoglycan biosynthetic process (GO:0015012)7.18119154
5carnitine transmembrane transport (GO:1902603)6.45882207
6regulation of transcription from RNA polymerase II promoter in response to hypoxia (GO:0061418)6.41156210
7regulation of G0 to G1 transition (GO:0070316)6.37890293
8ventricular septum morphogenesis (GO:0060412)6.26772484
9G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071995.93726630
10carnitine transport (GO:0015879)5.88446829
11amino-acid betaine transport (GO:0015838)5.88446829
12organic cation transport (GO:0015695)5.48423200
13establishment of planar polarity (GO:0001736)5.33841942
14establishment of tissue polarity (GO:0007164)5.33841942
15trabecula formation (GO:0060343)5.26301466
16ribosomal small subunit assembly (GO:0000028)5.18977372
17negative regulation of chemokine production (GO:0032682)5.18485234
18quaternary ammonium group transport (GO:0015697)5.15374527
19autophagic vacuole fusion (GO:0000046)5.14223341
20rRNA transcription (GO:0009303)5.11561231
21nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)5.05735673
22negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.01464221
23regulation of interleukin-8 biosynthetic process (GO:0045414)4.94213651
24negative regulation of mRNA metabolic process (GO:1903312)4.85827923
25negative regulation of interleukin-8 production (GO:0032717)4.81555155
26negative regulation of nucleotide catabolic process (GO:0030812)4.77789661
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.69802939
28N-acetylglucosamine metabolic process (GO:0006044)4.62737493
29negative regulation of purine nucleotide catabolic process (GO:0033122)4.56602434
30drug transmembrane transport (GO:0006855)4.54699534
31response to methylmercury (GO:0051597)4.50774718
32regulation of cell migration involved in sprouting angiogenesis (GO:0090049)4.38868770
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.30588668
34regulation of transcription from RNA polymerase II promoter in response to stress (GO:0043618)4.27475283
35proteoglycan biosynthetic process (GO:0030166)4.20060317
36heparan sulfate proteoglycan metabolic process (GO:0030201)4.17682234
37regulation of retinoic acid receptor signaling pathway (GO:0048385)4.16009922
38cellular response to fluid shear stress (GO:0071498)4.10066707
39negative regulation of glycogen biosynthetic process (GO:0045719)4.06239235
40response to muramyl dipeptide (GO:0032495)3.99075635
41regulation of DNA-templated transcription in response to stress (GO:0043620)3.88732856
42DNA replication initiation (GO:0006270)3.81019237
43organelle membrane fusion (GO:0090174)3.78506748
44positive regulation of protein homooligomerization (GO:0032464)3.75276116
45negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.70655127
46regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.70367077
47positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.70367077
48nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)3.69589417
49drug transport (GO:0015893)3.66660369
50gene silencing by RNA (GO:0031047)3.66504369
51Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.65536445
52regulation of heterotypic cell-cell adhesion (GO:0034114)3.60469978
53mannosylation (GO:0097502)3.60027529
54negative regulation of nitric-oxide synthase activity (GO:0051001)3.53468518
55rRNA modification (GO:0000154)3.52865919
56spliceosomal tri-snRNP complex assembly (GO:0000244)3.52697045
57regulation of establishment of planar polarity (GO:0090175)3.43487210
58histone H3-K9 methylation (GO:0051567)3.41170859
59regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.35759731
60positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.35759731
61negative regulation of cardiac muscle hypertrophy (GO:0010614)3.31037338
62cornea development in camera-type eye (GO:0061303)3.30492325
63response to nitrosative stress (GO:0051409)3.28929924
64ether lipid metabolic process (GO:0046485)3.28299175
65negative regulation of blood vessel endothelial cell migration (GO:0043537)3.28238416
66ncRNA 3-end processing (GO:0043628)3.21629871
67negative regulation of cAMP metabolic process (GO:0030815)3.18438773
68glucosamine-containing compound metabolic process (GO:1901071)3.16557376
69ribosomal small subunit biogenesis (GO:0042274)3.15885036
70response to peptidoglycan (GO:0032494)3.14837778
71negative regulation of mRNA processing (GO:0050686)3.12692214
72negative regulation of glycogen metabolic process (GO:0070874)3.12593097
73regulation of skeletal muscle contraction (GO:0014819)3.10110400
74negative regulation of cyclic nucleotide metabolic process (GO:0030800)3.07094969
75regulation of digestive system process (GO:0044058)3.04170269
76regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.03784266
77cardiac septum morphogenesis (GO:0060411)3.03471935
78GDP-mannose metabolic process (GO:0019673)3.02584375
79transcription from mitochondrial promoter (GO:0006390)3.02468355
80RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.02078296
81negative regulation of RNA splicing (GO:0033119)3.01742228
82ribosomal large subunit biogenesis (GO:0042273)3.00841658
83histone H3-K9 modification (GO:0061647)3.00730707
84telomere maintenance via semi-conservative replication (GO:0032201)2.98837877
85DNA double-strand break processing (GO:0000729)2.95797915
86centriole assembly (GO:0098534)2.95664874
87negative regulation of muscle hypertrophy (GO:0014741)2.95274502
88glycoprotein biosynthetic process (GO:0009101)2.92143465
89positive regulation of myotube differentiation (GO:0010831)2.89460496
90mitotic G2 DNA damage checkpoint (GO:0007095)2.88462924
91response to laminar fluid shear stress (GO:0034616)2.86669584
92purine nucleotide salvage (GO:0032261)2.82774259
93erythrocyte development (GO:0048821)2.82129347
94viral transcription (GO:0019083)2.81632397
95positive regulation of organelle assembly (GO:1902117)2.80209237
96labyrinthine layer development (GO:0060711)13.1402209
97peptidyl-proline hydroxylation (GO:0019511)11.6517843
98response to nitric oxide (GO:0071731)11.2160356
99protein hydroxylation (GO:0018126)11.0645548
1004-hydroxyproline metabolic process (GO:0019471)10.2942693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human6.56756496
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.24761196
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.91481146
4GATA1_22025678_ChIP-Seq_K562_Human3.70674719
5IGF1R_20145208_ChIP-Seq_DFB_Human3.38302084
6THAP11_20581084_ChIP-Seq_MESCs_Mouse3.17847251
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.17008158
8ESR1_20079471_ChIP-ChIP_T-47D_Human3.12279846
9VDR_21846776_ChIP-Seq_THP-1_Human3.06959723
10PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse2.65966948
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43120110
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.38483833
13NANOG_21062744_ChIP-ChIP_HESCs_Human2.28894912
14ZNF274_21170338_ChIP-Seq_K562_Hela2.10065077
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06092623
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03566600
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.97441524
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93925621
19FOXP3_21729870_ChIP-Seq_TREG_Human1.93287775
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.89179989
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88481240
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.87824250
23TTF2_22483619_ChIP-Seq_HELA_Human1.86015389
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85293543
25MYC_22102868_ChIP-Seq_BL_Human1.83143245
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82236458
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81680098
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78393809
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.77274313
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76232737
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76020937
32VDR_24763502_ChIP-Seq_THP-1_Human1.72460725
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65965825
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65181843
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.62635953
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61279440
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61094864
38CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.59186308
39XRN2_22483619_ChIP-Seq_HELA_Human1.55744165
40GABP_19822575_ChIP-Seq_HepG2_Human1.55426089
41E2F7_22180533_ChIP-Seq_HELA_Human1.53960221
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53590806
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49940343
44GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.49068390
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.46163112
46SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.43054792
47CIITA_25753668_ChIP-Seq_RAJI_Human1.43009008
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39887630
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38301045
50VDR_24787735_ChIP-Seq_THP-1_Human1.38143517
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32758513
52E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25255051
53STAT3_18555785_ChIP-Seq_MESCs_Mouse1.23234807
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.23117851
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22599012
56CTCF_21964334_Chip-Seq_Bcells_Human1.20932696
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18223235
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17992664
59PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17182451
60MYB_26560356_Chip-Seq_TH2_Human1.15531646
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.13014998
62YY1_22570637_ChIP-Seq_MALME-3M_Human1.12598636
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12462364
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10205058
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07697572
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.07678001
67VDR_23849224_ChIP-Seq_CD4+_Human1.07593175
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07277926
69IRF1_19129219_ChIP-ChIP_H3396_Human1.05545101
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.05404292
71HTT_18923047_ChIP-ChIP_STHdh_Human1.00181515
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00142209
73TCF7_22412390_ChIP-Seq_EML_Mouse0.97211499
74TP53_22573176_ChIP-Seq_HFKS_Human0.96136110
75MYB_26560356_Chip-Seq_TH1_Human0.95610109
76IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95392516
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95256298
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94769061
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94721135
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94570523
81EGR1_19374776_ChIP-ChIP_THP-1_Human0.93871795
82CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93675263
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92665412
84* FOXA1_25329375_ChIP-Seq_VCAP_Human0.91732998
85* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91732998
86TP53_22127205_ChIP-Seq_IMR90_Human0.91317003
87MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90040003
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89170897
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89170897
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89170897
91KDM5A_27292631_Chip-Seq_BREAST_Human0.88910358
92ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88483014
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.88470960
94SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.87691368
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86167551
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85897882
97* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.83007680
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80993770
99HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80073228
100BRD4_27068464_Chip-Seq_AML-cells_Mouse0.79837785

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract8.12427347
2MP0002132_abnormal_respiratory_system4.25290441
3MP0004484_altered_response_of4.17813985
4MP0000383_abnormal_hair_follicle4.04085193
5MP0003806_abnormal_nucleotide_metabolis3.86568023
6MP0003646_muscle_fatigue3.85888610
7MP0001986_abnormal_taste_sensitivity3.71262356
8MP0005423_abnormal_somatic_nervous3.62445918
9MP0009278_abnormal_bone_marrow3.46493405
10MP0005084_abnormal_gallbladder_morpholo3.36507597
11MP0001835_abnormal_antigen_presentation2.81440737
12MP0010678_abnormal_skin_adnexa2.67577265
13MP0001529_abnormal_vocalization2.54197293
14MP0003786_premature_aging2.40699605
15MP0003123_paternal_imprinting2.33682082
16MP0008995_early_reproductive_senescence2.29548321
17MP0004233_abnormal_muscle_weight2.10998544
18MP0005330_cardiomyopathy1.99450406
19MP0003303_peritoneal_inflammation1.92134978
20MP0005058_abnormal_lysosome_morphology1.79750598
21MP0003787_abnormal_imprinting1.78924870
22MP0001545_abnormal_hematopoietic_system1.55249671
23MP0005397_hematopoietic_system_phenotyp1.55249671
24MP0004185_abnormal_adipocyte_glucose1.51839184
25MP0005464_abnormal_platelet_physiology1.47992078
26MP0010630_abnormal_cardiac_muscle1.45344231
27MP0010368_abnormal_lymphatic_system1.40446662
28MP0006035_abnormal_mitochondrial_morpho1.37538010
29MP0005076_abnormal_cell_differentiation1.36233084
30MP0003077_abnormal_cell_cycle1.32955315
31MP0003221_abnormal_cardiomyocyte_apopto1.30112025
32MP0003111_abnormal_nucleus_morphology1.30074148
33MP0003121_genomic_imprinting1.27264521
34MP0009333_abnormal_splenocyte_physiolog1.22702582
35MP0002160_abnormal_reproductive_system1.19144036
36MP0000490_abnormal_crypts_of1.15414958
37MP0000920_abnormal_myelination1.15365686
38MP0004147_increased_porphyrin_level1.12446525
39MP0008770_decreased_survivor_rate1.09937873
40MP0010307_abnormal_tumor_latency1.09542393
41MP0000598_abnormal_liver_morphology1.07599614
42MP0003567_abnormal_fetal_cardiomyocyte1.06210152
43MP0004264_abnormal_extraembryonic_tissu1.06206069
44MP0001661_extended_life_span1.00613367
45MP0001873_stomach_inflammation0.99501940
46MP0002653_abnormal_ependyma_morphology0.99289612
47MP0004134_abnormal_chest_morphology0.99085032
48MP0003252_abnormal_bile_duct0.96303065
49MP0003959_abnormal_lean_body0.96255329
50MP0008058_abnormal_DNA_repair0.89766640
51MP0005389_reproductive_system_phenotype0.87222765
52MP0002822_catalepsy0.86944273
53MP0002722_abnormal_immune_system0.86742476
54MP0008007_abnormal_cellular_replicative0.85569147
55MP0009931_abnormal_skin_appearance0.85171417
56MP0001849_ear_inflammation0.82521289
57MP0004957_abnormal_blastocyst_morpholog0.79059743
58MP0000678_abnormal_parathyroid_gland0.77509519
59MP0003315_abnormal_perineum_morphology0.76330437
60MP0005385_cardiovascular_system_phenoty0.75464887
61MP0001544_abnormal_cardiovascular_syste0.75464887
62MP0001440_abnormal_grooming_behavior0.74582938
63MP0003718_maternal_effect0.74512519
64MP0002127_abnormal_cardiovascular_syste0.73793279
65MP0000716_abnormal_immune_system0.72025204
66MP0008874_decreased_physiological_sensi0.71446940
67MP0008260_abnormal_autophagy0.70115913
68MP0006082_CNS_inflammation0.68669546
69MP0005085_abnormal_gallbladder_physiolo0.68401444
70MP0000477_abnormal_intestine_morphology0.67629000
71MP0005025_abnormal_response_to0.67420865
72MP0001730_embryonic_growth_arrest0.67120566
73MP0003866_abnormal_defecation0.66777873
74MP0002083_premature_death0.65625271
75MP0000689_abnormal_spleen_morphology0.65050078
76MP0002419_abnormal_innate_immunity0.63350061
77MP0001919_abnormal_reproductive_system0.62813565
78MP0000358_abnormal_cell_content/0.62798430
79MP0002429_abnormal_blood_cell0.62707832
80MP0009379_abnormal_foot_pigmentation0.62473993
81MP0003942_abnormal_urinary_system0.62365635
82MP0002086_abnormal_extraembryonic_tissu0.62258623
83MP0000462_abnormal_digestive_system0.61864501
84MP0001905_abnormal_dopamine_level0.59512770
85MP0002148_abnormal_hypersensitivity_rea0.58806712
86MP0000703_abnormal_thymus_morphology0.56411690
87MP0003880_abnormal_central_pattern0.54169510
88MP0000249_abnormal_blood_vessel0.52491302
89MP0000266_abnormal_heart_morphology0.52438349
90MP0004036_abnormal_muscle_relaxation0.52374525
91MP0000465_gastrointestinal_hemorrhage0.51243291
92MP0003984_embryonic_growth_retardation0.49922953
93MP0002420_abnormal_adaptive_immunity0.49894289
94MP0004808_abnormal_hematopoietic_stem0.49686488
95MP0001819_abnormal_immune_cell0.49651364
96MP0003948_abnormal_gas_homeostasis0.49595655
97MP0001672_abnormal_embryogenesis/_devel0.48899513
98MP0005380_embryogenesis_phenotype0.48899513
99MP0001853_heart_inflammation0.48728871
100MP0002398_abnormal_bone_marrow0.48663065

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)7.02214750
2Loss of speech (HP:0002371)5.60110210
3Confusion (HP:0001289)5.56299654
4Cerebellar dysplasia (HP:0007033)4.76734979
5Reduced antithrombin III activity (HP:0001976)4.62559046
6Elevated erythrocyte sedimentation rate (HP:0003565)4.56579133
7Partial agenesis of the corpus callosum (HP:0001338)4.38382072
8Abnormality of urine glucose concentration (HP:0011016)4.09104293
9Glycosuria (HP:0003076)4.09104293
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.08983477
11Stomatitis (HP:0010280)4.06925681
12Bulbar palsy (HP:0001283)3.87896227
13Patent foramen ovale (HP:0001655)3.82196671
14Type I transferrin isoform profile (HP:0003642)3.77824330
15Abnormal gallbladder physiology (HP:0012438)3.72121155
16Cholecystitis (HP:0001082)3.72121155
17Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.62712814
18Increased cerebral lipofuscin (HP:0011813)3.57251098
19Visual hallucinations (HP:0002367)3.53059705
20Hyperammonemia (HP:0001987)3.32044003
21Prolonged partial thromboplastin time (HP:0003645)3.29439595
22Abnormality of alanine metabolism (HP:0010916)3.27218734
23Hyperalaninemia (HP:0003348)3.27218734
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.27218734
25Thrombocytosis (HP:0001894)3.22626098
26Hypercortisolism (HP:0001578)3.21997268
27Pseudobulbar signs (HP:0002200)3.21413227
28Abnormal protein glycosylation (HP:0012346)3.18398297
29Abnormal glycosylation (HP:0012345)3.18398297
30Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.18398297
31Abnormal protein N-linked glycosylation (HP:0012347)3.18398297
32Spontaneous hematomas (HP:0007420)3.11063896
33Myopathic facies (HP:0002058)2.97186914
34Episodic fever (HP:0001954)2.96485682
35Increased CSF protein (HP:0002922)2.83731021
36Male infertility (HP:0003251)2.79214691
37Hypoglycemic seizures (HP:0002173)2.74826214
38Lower limb hyperreflexia (HP:0002395)2.74297109
39Heterotopia (HP:0002282)2.72944317
40Amyloidosis (HP:0011034)2.69597797
41Cardiomegaly (HP:0001640)2.67259220
42Abnormality of the vocal cords (HP:0008777)2.64620748
43Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.63663784
44Increased intramyocellular lipid droplets (HP:0012240)2.62249481
45Severe visual impairment (HP:0001141)2.57197348
46Double outlet right ventricle (HP:0001719)2.54382222
47Congenital malformation of the right heart (HP:0011723)2.54382222
48Lipid accumulation in hepatocytes (HP:0006561)2.53664038
49Broad distal phalanx of finger (HP:0009836)2.52967120
50Hypoplasia of the uterus (HP:0000013)2.48941649
51Increased hepatocellular lipid droplets (HP:0006565)2.47567265
52Increased muscle lipid content (HP:0009058)2.45578477
53Neurofibrillary tangles (HP:0002185)2.43811123
54Ankle contracture (HP:0006466)2.40830300
55Tinnitus (HP:0000360)2.39537770
56Peripheral demyelination (HP:0011096)2.38441183
57Exertional dyspnea (HP:0002875)2.32328058
58Renal Fanconi syndrome (HP:0001994)2.31150729
59Nephronophthisis (HP:0000090)2.30843185
60Increased IgE level (HP:0003212)2.26159284
61Abnormality of the fetal cardiovascular system (HP:0010948)2.23587346
62Abnormal umbilical cord blood vessels (HP:0011403)2.23587346
63Single umbilical artery (HP:0001195)2.23587346
64Neurodegeneration (HP:0002180)2.22865289
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.22375434
66Rhabdomyolysis (HP:0003201)2.20748868
67Tetraplegia (HP:0002445)2.20203851
68Flat face (HP:0012368)2.17194147
69EMG: neuropathic changes (HP:0003445)2.10283737
70Aplasia/hypoplasia of the uterus (HP:0008684)2.08175260
71Abnormal hemoglobin (HP:0011902)2.06837621
72Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.05155447
73Obstructive lung disease (HP:0006536)2.03654106
74Chronic obstructive pulmonary disease (HP:0006510)2.03654106
75Microretrognathia (HP:0000308)2.03041867
76Abnormality of B cell number (HP:0010975)2.01894886
77Agnosia (HP:0010524)2.00986654
78Polycythemia (HP:0001901)10.3176505
79Hypochromic anemia (HP:0001931)1.98096242
80Multiple enchondromatosis (HP:0005701)1.96030684
81Right ventricular cardiomyopathy (HP:0011663)1.94181984
82Mask-like facies (HP:0000298)1.93061083
83Delusions (HP:0000746)1.92724971
84Polyneuropathy (HP:0001271)1.87938504
85Abnormality of the endocardium (HP:0004306)1.82917897
86True hermaphroditism (HP:0010459)1.78168637
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77576081
88Palpitations (HP:0001962)1.76753836
89Central scotoma (HP:0000603)1.76531940
90B lymphocytopenia (HP:0010976)1.74786585
91Ependymoma (HP:0002888)1.71832210
92Symptomatic seizures (HP:0011145)1.69046393
93Broad thumb (HP:0011304)1.69028590
94Cerebral inclusion bodies (HP:0100314)1.68478924
95Ileus (HP:0002595)1.68331687
96Urinary bladder sphincter dysfunction (HP:0002839)1.66800418
97Aplasia/Hypoplasia of the thymus (HP:0010515)1.65986762
98Abnormal platelet volume (HP:0011876)1.64764503
99Palpebral edema (HP:0100540)1.64677191
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.62166526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK9.51015050
2TAOK36.82431330
3SCYL25.06717054
4MAP3K64.65099717
5MAP2K33.88081358
6BCKDK2.86139659
7MAPK72.71363915
8PLK42.51521674
9RET1.88947528
10MAP2K41.82164124
11MAP2K61.79059501
12MAP3K51.71156684
13TXK1.67406147
14ZAP701.50899611
15BMPR21.32638964
16BRSK21.18138051
17TESK21.11999803
18MAP4K11.10346540
19STK161.03021221
20PLK20.95980016
21TYK20.94115122
22STK38L0.82330684
23NME20.80513709
24MINK10.78625869
25TNK20.75622966
26MAP3K10.72287126
27CDK30.71816766
28ZAK0.71702661
29RPS6KB10.64888831
30JAK30.64880613
31CDK120.62356560
32PRKD30.60789824
33BRSK10.59530877
34TBK10.57820730
35SGK30.56728025
36PASK0.55186129
37CDK190.54844962
38RPS6KB20.54195791
39IKBKB0.53700137
40ABL20.53543629
41PRKCH0.52974238
42PRPF4B0.52772896
43MARK30.52351332
44PTK20.50416408
45GRK10.49488911
46NEK90.49396289
47WEE10.48084246
48MAP3K30.47756326
49KIT0.45968514
50AURKA0.41415738
51RPS6KC10.40854096
52RPS6KL10.40854096
53KDR0.40377754
54GRK70.39098567
55BTK0.38930536
56SGK20.38788693
57AKT20.36241689
58ADRBK10.36186590
59PIM10.36155212
60BUB10.34407031
61RPS6KA60.33367369
62RPS6KA10.32548895
63IRAK30.30050290
64MAPK120.29452345
65MTOR0.28001101
66LYN0.27596350
67LCK0.26173058
68IKBKE0.25061730
69MAP3K40.23700516
70MARK20.21889174
71CDK80.21515187
72PRKACG0.19430430
73STK40.19356615
74STK100.19241755
75AKT10.18357466
76PRKCB0.18193911
77MAP2K70.16917938
78PRKCQ0.16672252
79MAPK130.16310358
80PLK10.16061512
81GRK60.15797631
82MAPK110.15784352
83FLT30.15508493
84BMX0.15251195
85EPHA40.14351690
86CSNK2A20.13901934
87PRKG20.13698831
88PRKCE0.13376508
89PDPK10.12989954
90CHEK20.12779165
91PIK3CG0.12397341
92PDK10.12046277
93FES0.11982518
94GSK3A0.11928188
95HCK0.11515939
96PAK20.10494889
97CSNK2A10.10330813
98MOS0.10165762
99MATK0.10150888
100SYK0.09749706

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005346.58799544
2Ribosome_Homo sapiens_hsa030104.22264134
3Fanconi anemia pathway_Homo sapiens_hsa034603.55850466
4RNA degradation_Homo sapiens_hsa030183.47516588
5DNA replication_Homo sapiens_hsa030303.28089740
6N-Glycan biosynthesis_Homo sapiens_hsa005102.74492377
7Fatty acid elongation_Homo sapiens_hsa000622.61231588
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.47080342
9Peroxisome_Homo sapiens_hsa041462.08979494
10Renal cell carcinoma_Homo sapiens_hsa052112.06081996
11mRNA surveillance pathway_Homo sapiens_hsa030151.97123239
12Spliceosome_Homo sapiens_hsa030401.94411467
13Pyrimidine metabolism_Homo sapiens_hsa002401.85870862
14Ether lipid metabolism_Homo sapiens_hsa005651.75958483
15RNA transport_Homo sapiens_hsa030131.75012756
16Retinol metabolism_Homo sapiens_hsa008301.68248538
17Basal cell carcinoma_Homo sapiens_hsa052171.64549593
18HIF-1 signaling pathway_Homo sapiens_hsa040661.53514998
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53235145
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.52522386
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41048171
22Longevity regulating pathway - mammal_Homo sapiens_hsa042111.25801779
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23719643
24Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20363111
25Linoleic acid metabolism_Homo sapiens_hsa005911.20134330
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12106271
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.09102228
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07998544
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07034559
30RNA polymerase_Homo sapiens_hsa030201.05356637
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03683205
32Leishmaniasis_Homo sapiens_hsa051401.02704316
33p53 signaling pathway_Homo sapiens_hsa041151.00860325
34ABC transporters_Homo sapiens_hsa020101.00320872
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97133072
36Drug metabolism - other enzymes_Homo sapiens_hsa009830.96166495
37Neurotrophin signaling pathway_Homo sapiens_hsa047220.95487130
38Collecting duct acid secretion_Homo sapiens_hsa049660.94696148
39Regulation of autophagy_Homo sapiens_hsa041400.94625468
40Lysosome_Homo sapiens_hsa041420.93491569
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91504427
42Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87984833
43Shigellosis_Homo sapiens_hsa051310.87249939
44Tuberculosis_Homo sapiens_hsa051520.85921701
45Arachidonic acid metabolism_Homo sapiens_hsa005900.82555596
46Glutathione metabolism_Homo sapiens_hsa004800.79310199
47Choline metabolism in cancer_Homo sapiens_hsa052310.77383090
48Asthma_Homo sapiens_hsa053100.77122857
49Salmonella infection_Homo sapiens_hsa051320.76711845
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76005013
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70427064
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68063148
53Taste transduction_Homo sapiens_hsa047420.67351475
54Rheumatoid arthritis_Homo sapiens_hsa053230.65011263
55Inositol phosphate metabolism_Homo sapiens_hsa005620.63910281
56Sphingolipid metabolism_Homo sapiens_hsa006000.62714724
57Pertussis_Homo sapiens_hsa051330.60872319
58Arginine and proline metabolism_Homo sapiens_hsa003300.58865019
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57024138
60Osteoclast differentiation_Homo sapiens_hsa043800.54231411
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53688415
62Antigen processing and presentation_Homo sapiens_hsa046120.52373485
63TNF signaling pathway_Homo sapiens_hsa046680.52306918
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.51846815
65Purine metabolism_Homo sapiens_hsa002300.50280724
66HTLV-I infection_Homo sapiens_hsa051660.50167414
67T cell receptor signaling pathway_Homo sapiens_hsa046600.48274310
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44157192
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43810904
70Dorso-ventral axis formation_Homo sapiens_hsa043200.43432429
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.43353422
72Melanogenesis_Homo sapiens_hsa049160.42871875
73Legionellosis_Homo sapiens_hsa051340.42850500
74Wnt signaling pathway_Homo sapiens_hsa043100.41628633
75Staphylococcus aureus infection_Homo sapiens_hsa051500.39560183
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38776249
77Fatty acid biosynthesis_Homo sapiens_hsa000610.37001718
78Influenza A_Homo sapiens_hsa051640.34806698
79Metabolic pathways_Homo sapiens_hsa011000.33961976
80Pathways in cancer_Homo sapiens_hsa052000.33469626
81Pancreatic secretion_Homo sapiens_hsa049720.33397714
82Nicotine addiction_Homo sapiens_hsa050330.32730265
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.32461415
84Toxoplasmosis_Homo sapiens_hsa051450.32156457
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32049116
86Hedgehog signaling pathway_Homo sapiens_hsa043400.29967762
87Folate biosynthesis_Homo sapiens_hsa007900.29512627
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24440956
89Mismatch repair_Homo sapiens_hsa034300.20101134
90MAPK signaling pathway_Homo sapiens_hsa040100.17619045
91Ovarian steroidogenesis_Homo sapiens_hsa049130.17186078
92mTOR signaling pathway_Homo sapiens_hsa041500.17010898
93Insulin resistance_Homo sapiens_hsa049310.16537061
94Type II diabetes mellitus_Homo sapiens_hsa049300.15889096
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.14930105
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.13964800
97Epstein-Barr virus infection_Homo sapiens_hsa051690.13708569
98Steroid biosynthesis_Homo sapiens_hsa001000.13168292
99FoxO signaling pathway_Homo sapiens_hsa040680.13158714
100VEGF signaling pathway_Homo sapiens_hsa043700.12515956

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