MLPH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cyclooxygenase pathway (GO:0019371)5.95197069
2COPI coating of Golgi vesicle (GO:0048205)5.51858444
3Golgi transport vesicle coating (GO:0048200)5.51858444
4protein targeting to Golgi (GO:0000042)5.35198962
5retrograde transport, vesicle recycling within Golgi (GO:0000301)5.21031462
6endothelial cell chemotaxis (GO:0035767)4.94791307
7ear development (GO:0043583)4.85077783
8establishment of protein localization to Golgi (GO:0072600)4.73181434
9melanin biosynthetic process (GO:0042438)4.63559415
10hemidesmosome assembly (GO:0031581)4.50440566
11semaphorin-plexin signaling pathway (GO:0071526)4.46100894
12dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.41327786
13negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.37051749
14negative regulation of cell size (GO:0045792)4.19645260
15melanin metabolic process (GO:0006582)4.12434197
16negative regulation of cAMP-mediated signaling (GO:0043951)4.09348719
17primary alcohol catabolic process (GO:0034310)3.85292643
18mannose metabolic process (GO:0006013)3.80712864
19receptor catabolic process (GO:0032801)3.78980064
20axonemal dynein complex assembly (GO:0070286)3.75494594
21regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.68194257
22secondary metabolite biosynthetic process (GO:0044550)3.67915102
23macrophage chemotaxis (GO:0048246)3.64699387
24positive regulation of keratinocyte differentiation (GO:0045618)3.58991661
25surfactant homeostasis (GO:0043129)3.57630919
26retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.57476657
27response to muramyl dipeptide (GO:0032495)3.57316372
28N-glycan processing (GO:0006491)3.53244074
29insulin-like growth factor receptor signaling pathway (GO:0048009)3.52349173
30vascular endothelial growth factor signaling pathway (GO:0038084)3.49215523
31monocyte chemotaxis (GO:0002548)3.47950979
32prostaglandin metabolic process (GO:0006693)3.42938478
33prostanoid metabolic process (GO:0006692)3.42938478
34regulation of cell proliferation involved in kidney development (GO:1901722)3.42315278
35positive regulation of cAMP-mediated signaling (GO:0043950)3.40593740
36regulation of fatty acid beta-oxidation (GO:0031998)3.40008117
37artery development (GO:0060840)3.37359295
38branching involved in prostate gland morphogenesis (GO:0060442)3.36630352
39maternal placenta development (GO:0001893)3.33359498
40striated muscle atrophy (GO:0014891)3.31912064
41amyloid precursor protein catabolic process (GO:0042987)3.29022408
42multicellular organismal water homeostasis (GO:0050891)3.27892820
43regulation of water loss via skin (GO:0033561)3.26756226
44regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.25794537
45protein localization to Golgi apparatus (GO:0034067)3.24914063
46ectoderm development (GO:0007398)3.22793234
47GDP-mannose metabolic process (GO:0019673)3.19560335
48motile cilium assembly (GO:0044458)3.18976707
49regulation of vitamin metabolic process (GO:0030656)3.16997022
50positive regulation of Cdc42 GTPase activity (GO:0043089)3.15418893
51apoptotic cell clearance (GO:0043277)3.14340899
52regulation of interleukin-13 production (GO:0032656)3.13923496
53regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.13411411
54vitamin transmembrane transport (GO:0035461)3.09702672
55tolerance induction (GO:0002507)3.08983191
56positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.07638763
57maintenance of gastrointestinal epithelium (GO:0030277)3.07225280
58norepinephrine metabolic process (GO:0042415)3.07018125
59cilium or flagellum-dependent cell motility (GO:0001539)3.06203427
60muscle cell migration (GO:0014812)3.05866154
61face development (GO:0060324)3.05679623
62chemical homeostasis within a tissue (GO:0048875)3.02373202
63intestinal epithelial cell development (GO:0060576)3.01383754
64iron ion import (GO:0097286)3.00826527
65lung secretory cell differentiation (GO:0061140)2.96658729
66bile acid and bile salt transport (GO:0015721)2.95118133
67positive regulation of glycoprotein biosynthetic process (GO:0010560)2.92659143
68positive regulation of blood vessel endothelial cell migration (GO:0043536)2.92544383
69histone H4-K12 acetylation (GO:0043983)2.92094335
70lung epithelium development (GO:0060428)2.91993381
71positive regulation of fatty acid beta-oxidation (GO:0032000)2.91058498
72protein retention in ER lumen (GO:0006621)2.89205921
73G-protein coupled receptor internalization (GO:0002031)2.88859556
74skeletal muscle adaptation (GO:0043501)2.88147090
75prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.87825577
76negative regulation of keratinocyte proliferation (GO:0010839)2.86452667
77fucose catabolic process (GO:0019317)2.86314256
78L-fucose metabolic process (GO:0042354)2.86314256
79L-fucose catabolic process (GO:0042355)2.86314256
80renal filtration (GO:0097205)2.86225473
81sulfate transmembrane transport (GO:1902358)2.85721816
82response to water (GO:0009415)2.85523879
83positive regulation of epidermal cell differentiation (GO:0045606)2.84946049
84bundle of His cell to Purkinje myocyte communication (GO:0086069)2.84921452
85regulation of endothelial cell chemotaxis (GO:2001026)2.84805905
86regulation of ruffle assembly (GO:1900027)2.84338516
87glutathione derivative metabolic process (GO:1901685)2.84331865
88glutathione derivative biosynthetic process (GO:1901687)2.84331865
89glandular epithelial cell differentiation (GO:0002067)2.83372659
90ethanol metabolic process (GO:0006067)2.82575541
91thyroid hormone generation (GO:0006590)2.82359561
92apical protein localization (GO:0045176)2.80440762
93G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.79838770
94mammary gland epithelial cell proliferation (GO:0033598)2.78201584
95cardiac right ventricle morphogenesis (GO:0003215)2.77666564
96positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.77485986
97negative regulation of fatty acid transport (GO:2000192)2.76178989
98basement membrane organization (GO:0071711)2.75874238
99COPII vesicle coating (GO:0048208)2.75662023
100filopodium assembly (GO:0046847)2.74417162
101regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.74142373
102regulation of autophagic vacuole assembly (GO:2000785)2.73365402
103regulation of histone H3-K27 methylation (GO:0061085)2.73336541
104establishment of apical/basal cell polarity (GO:0035089)2.72752393
105regulation of energy homeostasis (GO:2000505)2.72730637
106water homeostasis (GO:0030104)2.72235771
107proline biosynthetic process (GO:0006561)2.71887490
108muscle atrophy (GO:0014889)2.71819386
109regulation of integrin-mediated signaling pathway (GO:2001044)2.71587583
110quaternary ammonium group transport (GO:0015697)2.71107902
111maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.70795266
112positive regulation of myoblast differentiation (GO:0045663)2.70580278
113regulation of interleukin-5 production (GO:0032674)2.70551737
114endocrine hormone secretion (GO:0060986)2.68340132
115negative regulation of kidney development (GO:0090185)2.68203566
116cilium movement (GO:0003341)2.66795860
117tyrosine metabolic process (GO:0006570)2.64731233
118regulation of establishment or maintenance of cell polarity (GO:0032878)2.63304800
119adherens junction assembly (GO:0034333)2.62578227
120protein kinase B signaling (GO:0043491)2.62545351
121embryonic camera-type eye morphogenesis (GO:0048596)2.61799970
122diterpenoid biosynthetic process (GO:0016102)2.60276412
123UDP-N-acetylglucosamine metabolic process (GO:0006047)2.59265408
124cell-cell junction maintenance (GO:0045217)2.59146491
125regulation of type B pancreatic cell apoptotic process (GO:2000674)2.58848950
126positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.58520805
127thyroid hormone metabolic process (GO:0042403)2.57322329
128positive regulation of histone deacetylation (GO:0031065)2.57252775
129phosphate ion homeostasis (GO:0055062)2.57235478
130trivalent inorganic anion homeostasis (GO:0072506)2.57235478
131macroautophagy (GO:0016236)2.56923759
132regulation of vitamin D biosynthetic process (GO:0060556)2.56882213
133sodium-independent organic anion transport (GO:0043252)2.56653376
134endothelial cell morphogenesis (GO:0001886)2.56226492
135O-glycan processing (GO:0016266)2.56017852
136mammary gland epithelial cell differentiation (GO:0060644)2.55027492
137epithelial structure maintenance (GO:0010669)2.54993857
138purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.54643879
139ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.54643879
140nucleoside bisphosphate biosynthetic process (GO:0033866)2.54643879
141amyloid precursor protein metabolic process (GO:0042982)2.53323281
142detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.53000167
143membrane protein intracellular domain proteolysis (GO:0031293)2.52419752
144endocardial cushion development (GO:0003197)2.52233712
145purinergic nucleotide receptor signaling pathway (GO:0035590)2.52119635
146regulation of glucose import in response to insulin stimulus (GO:2001273)2.51885842
147epithelial cell maturation (GO:0002070)2.50886376
148desmosome organization (GO:0002934)2.50497747
149transcytosis (GO:0045056)2.50276282
150asymmetric protein localization (GO:0008105)2.49144790
151establishment of skin barrier (GO:0061436)2.47333968
152activation of Rac GTPase activity (GO:0032863)2.46702902
153mammary gland alveolus development (GO:0060749)2.46245186
154columnar/cuboidal epithelial cell development (GO:0002066)2.46027472
155regulation of keratinocyte differentiation (GO:0045616)2.45291115
156regulation of ARF GTPase activity (GO:0032312)2.44913294
157fucose metabolic process (GO:0006004)2.44888989
158response to food (GO:0032094)2.44730227
159sulfate transport (GO:0008272)2.42767913
160positive regulation of glycoprotein metabolic process (GO:1903020)2.39904170
161interleukin-1-mediated signaling pathway (GO:0070498)2.38411010
162neuron remodeling (GO:0016322)2.35863952
163phospholipid scrambling (GO:0017121)2.34342548
164phosphatidylserine metabolic process (GO:0006658)2.33814335
165calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.33540877
166prostate gland epithelium morphogenesis (GO:0060740)2.32081307
167mitochondrion distribution (GO:0048311)2.30286448
168tight junction assembly (GO:0070830)2.25634921
169epithelial cell-cell adhesion (GO:0090136)2.25611045
170female genitalia development (GO:0030540)2.24631341
171response to interferon-alpha (GO:0035455)2.20928143
172histone H3-K4 trimethylation (GO:0080182)2.20516424
173bone morphogenesis (GO:0060349)2.20490865
174epithelial cell differentiation involved in prostate gland development (GO:0060742)2.20467339
175regulation of interleukin-12 biosynthetic process (GO:0045075)2.20224464
176phosphatidylserine acyl-chain remodeling (GO:0036150)2.19389919
177pantothenate metabolic process (GO:0015939)2.19165291
178hypotonic response (GO:0006971)2.19023547
179regulation of Cdc42 GTPase activity (GO:0043088)2.18926369
180regulation of vacuole organization (GO:0044088)2.18847200
181negative regulation of transcription by competitive promoter binding (GO:0010944)2.18683798
182positive regulation of bone mineralization (GO:0030501)2.18160839
183regulation of RIG-I signaling pathway (GO:0039535)2.17701982
184positive regulation of phagocytosis (GO:0050766)2.16443925
185positive regulation of natural killer cell differentiation (GO:0032825)2.15482002
186pharyngeal system development (GO:0060037)2.15457454
187branching involved in mammary gland duct morphogenesis (GO:0060444)2.14973790
188negative regulation of cholesterol transport (GO:0032375)2.14943577
189negative regulation of sterol transport (GO:0032372)2.14943577
190cellular response to exogenous dsRNA (GO:0071360)2.14889684
191peptide catabolic process (GO:0043171)2.13946177

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.49031433
2ZNF263_19887448_ChIP-Seq_K562_Human3.10436468
3HIF1A_21447827_ChIP-Seq_MCF-7_Human2.83642610
4ESR1_15608294_ChIP-ChIP_MCF-7_Human2.70093386
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.68417569
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.54231434
7ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.29230018
8* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.10177423
9LXR_22292898_ChIP-Seq_THP-1_Human2.09493409
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.03491257
11ELK3_25401928_ChIP-Seq_HUVEC_Human1.92025052
12FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.91652483
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89323052
14SOX2_27498859_Chip-Seq_STOMACH_Mouse1.86012727
15* GATA3_24758297_ChIP-Seq_MCF-7_Human1.84231518
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83981688
17PPAR_26484153_Chip-Seq_NCI-H1993_Human1.80822085
18CDX2_20551321_ChIP-Seq_CACO-2_Human1.78065041
19* DROSHA_22980978_ChIP-Seq_HELA_Human1.77881642
20AR_21572438_ChIP-Seq_LNCaP_Human1.77642409
21* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77404569
22* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76339133
23* SOX2_20726797_ChIP-Seq_SW620_Human1.69924029
24* AHR_22903824_ChIP-Seq_MCF-7_Human1.69922965
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.69348148
26KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.68927281
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67216592
28CLOCK_20551151_ChIP-Seq_293T_Human1.65094803
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63410732
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61643249
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.60925013
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60899560
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.55962627
34GBX2_23144817_ChIP-Seq_PC3_Human1.52729625
35TP53_16413492_ChIP-PET_HCT116_Human1.51184353
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50879711
37* GATA4_25053715_ChIP-Seq_YYC3_Human1.50413602
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.49922690
39CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.49707279
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49581860
41CREB1_26743006_Chip-Seq_LNCaP_Human1.48847095
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48195523
43* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45969422
44* ATF3_27146783_Chip-Seq_COLON_Human1.45381114
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44921796
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.44824915
47SMC4_20622854_ChIP-Seq_HELA_Human1.44737151
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44391341
49* ARNT_22903824_ChIP-Seq_MCF-7_Human1.43462129
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.43305601
51* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39394018
52* ESR1_20079471_ChIP-ChIP_T-47D_Human1.37939165
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.37345081
54TCF7_22412390_ChIP-Seq_EML_Mouse1.37077466
55P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35984738
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35304751
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.34940368
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34756476
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34429914
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32528659
61FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.31629331
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.31466189
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.31379868
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31370204
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31330750
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31054808
67P68_20966046_ChIP-Seq_HELA_Human1.30710300
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28224027
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26796495
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24671490
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23947321
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22773458
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22164968
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22086400
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21656075
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.20165980
77* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20068113
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18462432
79KDM2B_26808549_Chip-Seq_K562_Human1.18010182
80* EZH2_27294783_Chip-Seq_ESCs_Mouse1.15476505
81FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14793801
82EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14361487
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14318213
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14150566
85JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14146970
86TP63_22573176_ChIP-Seq_HFKS_Human1.13786937
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13505116
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13396606
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13385631
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12595284
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.12127299
92* RUNX1_27514584_Chip-Seq_MCF-7_Human1.11079253
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11009745
94EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10930773
95RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10930773
96* FOXA2_19822575_ChIP-Seq_HepG2_Human1.10823547
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09416005
98JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09413751
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08950364
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08594088
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08503323
102RARB_24833708_ChIP-Seq_LIVER_Mouse1.07470226
103ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07208278
104* ELF5_23300383_ChIP-Seq_T47D_Human1.07083575
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06524230
106P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06358965
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05912132
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05912132
109KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05912132
110EED_16625203_ChIP-ChIP_MESCs_Mouse1.04495169
111PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04324817
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04107771
113TP53_22127205_ChIP-Seq_IMR90_Human1.03823982
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03567051
115KLF5_25053715_ChIP-Seq_YYC3_Human1.03246153
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03230056
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03022746
118TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00527250
119SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00133155
120* KDM2B_26808549_Chip-Seq_DND41_Human1.00061811
121CHD1_26751641_Chip-Seq_LNCaP_Human0.99848335
122TET1_21490601_ChIP-Seq_MESCs_Mouse0.99506362
123IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99399808
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98253058
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98007638
126CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97727443
127TP53_18474530_ChIP-ChIP_U2OS_Human0.96780207
128NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96432367
129CTCF_27219007_Chip-Seq_Bcells_Human0.95524189
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94879663
131* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93847007
132RNF2_27304074_Chip-Seq_ESCs_Mouse0.93267601
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93020650
134VDR_24787735_ChIP-Seq_THP-1_Human0.92946340
135KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92902580
136SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92878717
137SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92878717
138NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92789678
139* CJUN_26792858_Chip-Seq_BT549_Human0.91992026
140EZH2_27304074_Chip-Seq_ESCs_Mouse0.91075813
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90881648
142SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90730272
143GATA6_25053715_ChIP-Seq_YYC3_Human0.90190325
144SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89592075
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89366892
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88918924
147SMAD_19615063_ChIP-ChIP_OVARY_Human0.88296737
148TP63_23658742_ChIP-Seq_EP156T_Human0.87421636
149RACK7_27058665_Chip-Seq_MCF-7_Human0.87067888
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.86267535
151SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86201060
152PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84262380
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84253817
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84253817
155ISL1_27105846_Chip-Seq_CPCs_Mouse0.82110661
156EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81794176
157CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81407307
158CBX2_27304074_Chip-Seq_ESCs_Mouse0.80822288
159JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80490032
160ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79428532
161TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78693538
162FOXA1_25552417_ChIP-Seq_VCAP_Human0.78007942
163BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77772589
164* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77652167

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH7.66247928
2MP0010234_abnormal_vibrissa_follicle3.88004534
3MP0004264_abnormal_extraembryonic_tissu3.87844188
4MP0003283_abnormal_digestive_organ3.65068299
5MP0005408_hypopigmentation3.42816821
6MP0003300_gastrointestinal_ulcer3.38923298
7MP0003705_abnormal_hypodermis_morpholog3.33914145
8MP0003045_fibrosis3.33909336
9MP0003303_peritoneal_inflammation3.21775484
10MP0004381_abnormal_hair_follicle2.97727416
11MP0005058_abnormal_lysosome_morphology2.79944920
12MP0001873_stomach_inflammation2.76590020
13MP0001664_abnormal_digestion2.72680750
14MP0000013_abnormal_adipose_tissue2.65463069
15MP0003866_abnormal_defecation2.63468628
16MP0009780_abnormal_chondrocyte_physiolo2.42290139
17MP0002877_abnormal_melanocyte_morpholog2.34014616
18MP0005083_abnormal_biliary_tract2.27970301
19MP0005076_abnormal_cell_differentiation2.23797603
20MP0003252_abnormal_bile_duct2.20791085
21MP0005310_abnormal_salivary_gland2.20695342
22MP0005257_abnormal_intraocular_pressure2.17896525
23MP0005381_digestive/alimentary_phenotyp2.01971616
24MP0001663_abnormal_digestive_system2.01399051
25MP0009384_cardiac_valve_regurgitation2.00676359
26MP0000462_abnormal_digestive_system1.95939454
27MP0003136_yellow_coat_color1.93304917
28MP0008260_abnormal_autophagy1.92182548
29MP0010386_abnormal_urinary_bladder1.90660234
30MP0000003_abnormal_adipose_tissue1.89871365
31MP0000372_irregular_coat_pigmentation1.86872333
32MP0000566_synostosis1.79083233
33MP0000470_abnormal_stomach_morphology1.78734088
34MP0005075_abnormal_melanosome_morpholog1.77926923
35MP0008438_abnormal_cutaneous_collagen1.75515073
36MP0001765_abnormal_ion_homeostasis1.74923061
37MP0001666_abnormal_nutrient_absorption1.68523974
38MP0000627_abnormal_mammary_gland1.64060442
39MP0002249_abnormal_larynx_morphology1.62942223
40MP0003172_abnormal_lysosome_physiology1.59364832
41MP0005451_abnormal_body_composition1.53531928
42MP0001188_hyperpigmentation1.51288542
43MP0008875_abnormal_xenobiotic_pharmacok1.49445070
44MP0005666_abnormal_adipose_tissue1.47460681
45MP0005409_darkened_coat_color1.47265302
46MP0010030_abnormal_orbit_morphology1.47116285
47MP0002060_abnormal_skin_morphology1.43957782
48MP0010678_abnormal_skin_adnexa1.40933000
49MP0000537_abnormal_urethra_morphology1.39115095
50MP0004019_abnormal_vitamin_homeostasis1.35410678
51MP0005501_abnormal_skin_physiology1.34826116
52MP0004885_abnormal_endolymph1.31848219
53MP0000678_abnormal_parathyroid_gland1.31241567
54MP0005220_abnormal_exocrine_pancreas1.31014001
55MP0009840_abnormal_foam_cell1.30427159
56MP0000467_abnormal_esophagus_morphology1.28854365
57MP0010155_abnormal_intestine_physiology1.28156421
58MP0003566_abnormal_cell_adhesion1.26287720
59MP0005360_urolithiasis1.25577776
60MP0000613_abnormal_salivary_gland1.24101623
61* MP0000371_diluted_coat_color1.23977958
62MP0004484_altered_response_of1.23584569
63MP0003191_abnormal_cellular_cholesterol1.22286463
64MP0005670_abnormal_white_adipose1.21886342
65MP0002653_abnormal_ependyma_morphology1.19861805
66MP0001958_emphysema1.19542345
67MP0005165_increased_susceptibility_to1.17958858
68MP0006138_congestive_heart_failure1.17952012
69MP0000477_abnormal_intestine_morphology1.15887951
70MP0000427_abnormal_hair_cycle1.14885454
71MP0000015_abnormal_ear_pigmentation1.13727204
72MP0002089_abnormal_postnatal_growth/wei1.10977612
73MP0003724_increased_susceptibility_to1.09670624
74MP0001346_abnormal_lacrimal_gland1.09198873
75MP0000377_abnormal_hair_follicle1.08294582
76MP0005171_absent_coat_pigmentation1.05762531
77MP0000538_abnormal_urinary_bladder1.05728959
78MP0002098_abnormal_vibrissa_morphology1.05253978
79MP0000751_myopathy1.04797638
80MP0004233_abnormal_muscle_weight1.01262941
81MP0000762_abnormal_tongue_morphology0.98107831
82MP0000767_abnormal_smooth_muscle0.97081739
83MP0003942_abnormal_urinary_system0.96372223
84MP0004043_abnormal_pH_regulation0.94663394
85MP0005365_abnormal_bile_salt0.94555422
86MP0004858_abnormal_nervous_system0.93967069
87MP0001502_abnormal_circadian_rhythm0.93400360
88MP0003183_abnormal_peptide_metabolism0.92103712
89MP0004185_abnormal_adipocyte_glucose0.91701730
90MP0003936_abnormal_reproductive_system0.91311609
91MP0005503_abnormal_tendon_morphology0.91205480
92MP0000681_abnormal_thyroid_gland0.90202336
93MP0010771_integument_phenotype0.89396045
94MP0001881_abnormal_mammary_gland0.88948689
95MP0005464_abnormal_platelet_physiology0.88533868
96MP0000534_abnormal_ureter_morphology0.88177682
97MP0001756_abnormal_urination0.87760624
98MP0005085_abnormal_gallbladder_physiolo0.87233699
99MP0005174_abnormal_tail_pigmentation0.87228713
100MP0000733_abnormal_muscle_development0.87147994
101MP0002998_abnormal_bone_remodeling0.87003499
102MP0002090_abnormal_vision0.86222495
103MP0002896_abnormal_bone_mineralization0.85092979
104MP0004272_abnormal_basement_membrane0.84721883
105MP0002282_abnormal_trachea_morphology0.84673867
106MP0000343_altered_response_to0.83959273
107MP0001533_abnormal_skeleton_physiology0.83935801
108MP0009379_abnormal_foot_pigmentation0.83345630
109MP0003123_paternal_imprinting0.82903723
110* MP0002075_abnormal_coat/hair_pigmentati0.82798125
111MP0001348_abnormal_lacrimal_gland0.82557662
112MP0002796_impaired_skin_barrier0.82048805
113* MP0001186_pigmentation_phenotype0.81824594
114MP0002277_abnormal_respiratory_mucosa0.81771705
115MP0001849_ear_inflammation0.81510970
116MP0002168_other_aberrant_phenotype0.80834958
117MP0002932_abnormal_joint_morphology0.80545069
118MP0000163_abnormal_cartilage_morphology0.80471378
119MP0000569_abnormal_digit_pigmentation0.79113220
120MP0001542_abnormal_bone_strength0.78637926
121MP0001270_distended_abdomen0.78321603
122MP0002971_abnormal_brown_adipose0.76639121
123MP0001299_abnormal_eye_distance/0.75934197
124MP0000383_abnormal_hair_follicle0.75714070
125MP0005367_renal/urinary_system_phenotyp0.75518565
126MP0000516_abnormal_urinary_system0.75518565
127MP0003091_abnormal_cell_migration0.75460727
128MP0003941_abnormal_skin_development0.75051600
129MP0009643_abnormal_urine_homeostasis0.74827948
130MP0000490_abnormal_crypts_of0.74265156
131MP0002108_abnormal_muscle_morphology0.73372575
132MP0003795_abnormal_bone_structure0.73310013
133MP0005647_abnormal_sex_gland0.71964922
134MP0008874_decreased_physiological_sensi0.70768515
135MP0005375_adipose_tissue_phenotype0.70479638
136MP0002909_abnormal_adrenal_gland0.70459394
137MP0000579_abnormal_nail_morphology0.70356727
138MP0008961_abnormal_basal_metabolism0.69437835
139MP0002115_abnormal_skeleton_extremities0.69053324
140MP0002166_altered_tumor_susceptibility0.68943551
141MP0003279_aneurysm0.68478582
142MP0005023_abnormal_wound_healing0.67821383
143MP0000230_abnormal_systemic_arterial0.67404349
144MP0002234_abnormal_pharynx_morphology0.65686634
145MP0004782_abnormal_surfactant_physiolog0.63946074
146MP0002136_abnormal_kidney_physiology0.62563915
147MP0005166_decreased_susceptibility_to0.62551306
148MP0005636_abnormal_mineral_homeostasis0.62472897
149MP0003453_abnormal_keratinocyte_physiol0.62005296
150MP0005248_abnormal_Harderian_gland0.61806767
151MP0001216_abnormal_epidermal_layer0.61705306
152MP0002876_abnormal_thyroid_physiology0.61470477
153MP0001440_abnormal_grooming_behavior0.61397457
154MP0004947_skin_inflammation0.59484916
155MP0001845_abnormal_inflammatory_respons0.58550102

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)7.12679115
2J-shaped sella turcica (HP:0002680)6.92131691
3Retinal atrophy (HP:0001105)4.58261227
4Broad face (HP:0000283)4.41946268
5Atrophic scars (HP:0001075)4.35590551
6Cervical subluxation (HP:0003308)4.15072184
7Colitis (HP:0002583)4.02737565
8Vacuolated lymphocytes (HP:0001922)4.00794237
9Deformed sella turcica (HP:0002681)3.79316688
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.75542955
11Right ventricular cardiomyopathy (HP:0011663)3.56937849
12Panhypogammaglobulinemia (HP:0003139)3.43099724
13Abnormality of small intestinal villus morphology (HP:0011472)3.42426978
14Villous atrophy (HP:0011473)3.42426978
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.39369711
16Distal lower limb muscle weakness (HP:0009053)3.34409031
17Aortic regurgitation (HP:0001659)3.31133332
18Inflammation of the large intestine (HP:0002037)3.30791618
19Milia (HP:0001056)3.26066537
20Alacrima (HP:0000522)3.24404183
21Hyperacusis (HP:0010780)3.21027516
22Interstitial pulmonary disease (HP:0006530)3.20209941
23Abnormality of polysaccharide metabolism (HP:0011012)3.20134564
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.20134564
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.20134564
26Dysostosis multiplex (HP:0000943)3.14332506
27Morphological abnormality of the inner ear (HP:0011390)3.01509050
28Urinary glycosaminoglycan excretion (HP:0003541)2.98134188
29Mucopolysacchariduria (HP:0008155)2.98134188
30Short nail (HP:0001799)2.98120030
31Stridor (HP:0010307)2.95916729
32Abnormality of the 2nd finger (HP:0004100)2.95250312
33Thin bony cortex (HP:0002753)2.94490261
34Gastrointestinal inflammation (HP:0004386)2.92594378
35Aortic aneurysm (HP:0004942)2.90888632
36Viral hepatitis (HP:0006562)2.89137712
37Chronic bronchitis (HP:0004469)2.89024999
38Abnormality of the distal phalanges of the toes (HP:0010182)2.87484021
39Hypopigmentation of the fundus (HP:0007894)2.83016246
40Agammaglobulinemia (HP:0004432)2.81209229
41Subcapsular cataract (HP:0000523)2.80906487
42Symphalangism affecting the phalanges of the hand (HP:0009773)2.80082110
43Abnormality of cochlea (HP:0000375)2.79780148
44Abnormal respiratory epithelium morphology (HP:0012253)2.77671950
45Abnormal respiratory motile cilium morphology (HP:0005938)2.77671950
46Absent frontal sinuses (HP:0002688)2.75601394
47Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.75364285
48Lymphangioma (HP:0100764)2.72570341
49Nuclear cataract (HP:0100018)2.71830985
50Hyperphosphatemia (HP:0002905)2.71573129
51Abnormality of the middle phalanges of the toes (HP:0010183)2.71401842
52Onycholysis (HP:0001806)2.70791375
53Abnormality of the sella turcica (HP:0002679)2.67509589
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.65111479
55Absent/shortened dynein arms (HP:0200106)2.65111479
56Aortic dissection (HP:0002647)2.64722771
57Abdominal distention (HP:0003270)2.64705829
58Asymmetry of the thorax (HP:0001555)2.61899591
59Abnormal respiratory motile cilium physiology (HP:0012261)2.57856174
60Rhinitis (HP:0012384)2.57054245
61Mildly elevated creatine phosphokinase (HP:0008180)2.55463619
62Recurrent cutaneous fungal infections (HP:0011370)2.55072616
63Chronic mucocutaneous candidiasis (HP:0002728)2.55072616
64Upper limb amyotrophy (HP:0009129)2.54491434
65Distal upper limb amyotrophy (HP:0007149)2.54491434
66Cerebral aneurysm (HP:0004944)2.50734089
67Abnormality of the proximal phalanges of the hand (HP:0009834)2.50721519
68Protrusio acetabuli (HP:0003179)2.49631198
69Long toe (HP:0010511)2.46888052
70Flat acetabular roof (HP:0003180)2.46001195
71Spondylolisthesis (HP:0003302)2.45425736
72Biconcave vertebral bodies (HP:0004586)2.44743567
73Short hallux (HP:0010109)2.44708244
74Abnormal ciliary motility (HP:0012262)2.44361537
75Abnormality of the phalanges of the 2nd finger (HP:0009541)2.43211458
76Testicular atrophy (HP:0000029)2.42982067
77Arterial tortuosity (HP:0005116)2.41866656
78Bell-shaped thorax (HP:0001591)2.41248804
79Aplasia/hypoplasia of the femur (HP:0005613)2.40433195
80Decreased lacrimation (HP:0000633)2.38180205
81Aplasia/Hypoplasia of the sacrum (HP:0008517)2.37488908
82Congenital sensorineural hearing impairment (HP:0008527)2.36689423
83Sparse lateral eyebrow (HP:0005338)2.35765260
84Aplasia involving bones of the extremities (HP:0009825)2.33297787
85Aplasia involving bones of the upper limbs (HP:0009823)2.33297787
86Aplasia of the phalanges of the hand (HP:0009802)2.33297787
87Short femoral neck (HP:0100864)2.32732053
88Increased connective tissue (HP:0009025)2.32459557
89Premature rupture of membranes (HP:0001788)2.31869034
90Glucose intolerance (HP:0000833)2.30888004
91Spinal cord compression (HP:0002176)2.27651999
92Camptodactyly of toe (HP:0001836)2.27418459
93Flattened epiphyses (HP:0003071)2.27379535
94Septate vagina (HP:0001153)2.26308017
95Nasal polyposis (HP:0100582)2.24685459
96Breast hypoplasia (HP:0003187)2.24558073
97Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.23991945
98Thoracic kyphosis (HP:0002942)2.21056189
99Hypoplasia of the ulna (HP:0003022)2.19739173
100Disproportionate tall stature (HP:0001519)2.19329293
101Limited hip movement (HP:0008800)2.16507544
102Vascular calcification (HP:0004934)2.15562859
103Aplasia/Hypoplasia of the hallux (HP:0008362)2.12486343
104Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.11927299
105Vascular tortuosity (HP:0004948)2.10186248
106Urethral obstruction (HP:0000796)2.07996652
107Atelectasis (HP:0100750)2.07836211
108Amelogenesis imperfecta (HP:0000705)2.07356462
109Abnormality of the nasal mucosa (HP:0000433)2.06972047
110Progressive sensorineural hearing impairment (HP:0000408)2.06920289
111Hand muscle atrophy (HP:0009130)2.05174097
112Vertebral compression fractures (HP:0002953)2.05112276
113Flat capital femoral epiphysis (HP:0003370)2.03953757
114Osteolytic defects of the phalanges of the hand (HP:0009771)2.01514694
115Osteolytic defects of the hand bones (HP:0009699)2.01514694
116Distal lower limb amyotrophy (HP:0008944)2.01312490
117Hyperactive renin-angiotensin system (HP:0000841)1.99565043
118Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.98901389
119Wormian bones (HP:0002645)1.97535530
120Loss of speech (HP:0002371)1.97030708
121Pili torti (HP:0003777)1.96872657
122Type I transferrin isoform profile (HP:0003642)1.96672554
123Polar cataract (HP:0010696)1.95815490
124Progressive visual loss (HP:0000529)1.93334410
125Hyperparathyroidism (HP:0000843)1.93293396
126Cardiovascular calcification (HP:0011915)1.91050848
127Xerostomia (HP:0000217)1.90528171
128Hypoplasia of dental enamel (HP:0006297)1.88434488
129Bronchomalacia (HP:0002780)1.88143957
130Macroorchidism (HP:0000053)1.87943360
131Renal salt wasting (HP:0000127)1.87154921
132Bronchiectasis (HP:0002110)1.86721666
133Congenital glaucoma (HP:0001087)1.86270480
134Lip pit (HP:0100267)1.86071230
135Male infertility (HP:0003251)1.85220220
136Germ cell neoplasia (HP:0100728)1.85189329
137Ependymoma (HP:0002888)1.84785925
138Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.84556473
139Abnormal foot bone ossification (HP:0010675)1.84375862
140Barrel-shaped chest (HP:0001552)1.84029920
141Femoral bowing (HP:0002980)1.83808556
142Abnormality of magnesium homeostasis (HP:0004921)1.83726348
143Abnormality of the lumbar spine (HP:0100712)1.83410903
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82146948
145Abnormality of the frontal sinuses (HP:0002687)1.81931349
146Neonatal short-limb short stature (HP:0008921)1.81508337
147Concave nail (HP:0001598)1.81267591
148Aplasia/Hypoplasia of the macula (HP:0008059)1.80686702
149Glomerulosclerosis (HP:0000096)1.79594219
150Abnormal tarsal ossification (HP:0008369)1.79302347
151Abnormal glucose tolerance (HP:0001952)1.78768738
152Aplasia/Hypoplasia of the fovea (HP:0008060)1.78268758
153Hypoplasia of the fovea (HP:0007750)1.78268758
154Abnormality of dentin (HP:0010299)1.77623791
155Hypoplasia of the uterus (HP:0000013)1.76124186
156Abnormal hair laboratory examination (HP:0003328)1.75694409
157Neoplasm of the heart (HP:0100544)1.74701086
158Increased neuronal autofluorescent lipopigment (HP:0002074)1.74396753
159Hypoplastic ischia (HP:0003175)1.74349956
160Aneurysm (HP:0002617)1.74117019
161Abnormality of chloride homeostasis (HP:0011422)1.72783923
162White forelock (HP:0002211)1.72505896
163Hypoplasia of the odontoid process (HP:0003311)1.72378049
164Easy fatigability (HP:0003388)1.72228048
165Abnormality of the umbilical cord (HP:0010881)1.72179868
166Obstructive sleep apnea (HP:0002870)1.71738231
167Hyperkalemia (HP:0002153)1.71541854
168Goiter (HP:0000853)1.70438311
169Joint stiffness (HP:0001387)1.70286488
170Bradycardia (HP:0001662)1.70088063
171Spinal rigidity (HP:0003306)1.69475679
172Natal tooth (HP:0000695)1.69064065
173Sleep apnea (HP:0010535)1.68303560
174Aplasia cutis congenita (HP:0001057)1.67988535
175Reduced antithrombin III activity (HP:0001976)1.65585033
176Abnormality of the intrinsic pathway (HP:0010989)1.65520481
177Abnormality of the thoracic spine (HP:0100711)1.65138854
178Hypoplastic pelvis (HP:0008839)1.63188629
179Posterior subcapsular cataract (HP:0007787)1.63061109
180Prolonged partial thromboplastin time (HP:0003645)1.61299503
181Abnormality of the distal phalanx of the thumb (HP:0009617)1.60946918

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.93893300
2TNIK5.36118495
3TAOK34.47318432
4EEF2K4.34070418
5MAP3K64.16828776
6PKN23.45592542
7MAP2K33.06822623
8MST42.88903939
9MAPKAPK32.75004633
10AKT32.61903815
11TESK12.60603733
12CDK32.49954998
13NUAK12.30525510
14MUSK2.16720457
15TRPM72.10886545
16STK392.09898833
17MST1R1.94721303
18NLK1.90682018
19EPHA21.83248493
20SMG11.75793814
21NME21.74585485
22DMPK1.72622009
23SCYL21.71592033
24MAP2K61.68906161
25FER1.65296673
26TGFBR21.60691759
27IRAK31.59284154
28ICK1.53572162
29ERN11.51382172
30FGFR41.45580242
31MAP2K41.44954147
32LATS11.44575104
33MYLK1.43345718
34MAPKAPK51.42620542
35NEK61.39842839
36ZAP701.34290946
37RPS6KB21.32865130
38FRK1.30491015
39PIK3CA1.21028078
40EIF2AK31.09818907
41TLK11.08303573
42PDGFRA1.07242894
43MTOR1.06557505
44NME11.03475955
45OXSR11.01790393
46LIMK11.01751790
47SIK10.99316619
48ILK0.95405817
49LMTK20.94918921
50LRRK20.94825618
51PIK3CG0.92894891
52ERBB40.90479434
53EPHB20.90437489
54RPS6KA40.90330340
55PRKD20.87540091
56IRAK10.84848921
57MAP3K30.84272368
58PDK20.83383418
59MAP2K10.83275645
60CDK70.82747875
61CDK120.78774952
62HIPK20.78217389
63IKBKB0.77622137
64STK100.77246407
65PRKD30.75457626
66PAK40.74101106
67MET0.72199483
68MAPK120.72174824
69PDPK10.71878412
70SIK30.70987266
71MARK20.70603848
72RET0.69989823
73INSRR0.67929924
74MAP2K20.67610008
75STK380.67451570
76CAMK1D0.66727779
77PHKG20.66479451
78PHKG10.66479451
79MAP3K20.66230210
80PRKD10.64138024
81PAK20.62784833
82PTK60.62721379
83MAPK150.62684313
84TTN0.58063711
85TESK20.56893760
86RPS6KL10.55377828
87RPS6KC10.55377828
88PRKAA20.53696674
89ADRBK10.53472812
90PDGFRB0.53260095
91NTRK10.52717090
92CAMK10.52545194
93EIF2AK20.52190911
94CDC42BPA0.51754643
95FES0.51626831
96MAPKAPK20.51250324
97DDR20.50923505
98CSK0.50705355
99YES10.50641968
100IGF1R0.50419519
101CAMK1G0.48691770
102CSNK1A1L0.48439111
103MAP3K120.47438467
104EPHB10.46272667
105RPS6KA60.45965729
106MAP3K70.45592515
107ROCK10.45357462
108WNK40.45063188
109TNK20.44620543
110TBK10.43827852
111KDR0.43816995
112MAPK130.43480721
113ZAK0.43273283
114MAPK70.42288152
115MAP3K40.41994910
116MAP2K70.41630868
117AKT20.41209085
118PTK20.38716767
119MATK0.38370506
120CASK0.38236468
121CDK80.38020200
122PRKG20.36029084
123BMX0.36019373
124CAMK2B0.36010142
125CAMK2D0.35917267
126RIPK10.35603509
127VRK20.35396655
128RIPK40.35299832
129EIF2AK10.35246113
130MAP3K50.33927968
131GRK60.32221869
132GSK3A0.31623454
133EGFR0.31391468
134GRK10.30863267
135ROCK20.30567153
136MELK0.30461043
137CAMK2G0.29877885
138FGR0.29751197
139PRKCI0.29691505
140FYN0.29380906
141NTRK30.29171435
142DAPK10.28333838
143PRKCQ0.28054520
144PRKAA10.27286905
145MAPK80.27261276
146TAOK10.27083039
147CSNK1G10.26405885
148IRAK40.26139291
149LATS20.25848191
150PIM20.25171053
151ERBB20.25164809
152RPS6KA20.24590944
153CHUK0.23911959
154PTK2B0.22930449
155CAMKK10.22824242

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009202.87282975
2Fructose and mannose metabolism_Homo sapiens_hsa000512.82566773
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.70796690
4Tyrosine metabolism_Homo sapiens_hsa003502.56167263
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.53225834
6Phenylalanine metabolism_Homo sapiens_hsa003602.45795354
7Other glycan degradation_Homo sapiens_hsa005112.37661519
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.32363531
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.08364837
10Histidine metabolism_Homo sapiens_hsa003402.00828848
11Arachidonic acid metabolism_Homo sapiens_hsa005901.95502923
12Notch signaling pathway_Homo sapiens_hsa043301.92782025
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.73586185
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64971776
15ABC transporters_Homo sapiens_hsa020101.63325027
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61109574
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54495112
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47787842
19Mineral absorption_Homo sapiens_hsa049781.47106721
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.45046947
21Chemical carcinogenesis_Homo sapiens_hsa052041.44347790
22mTOR signaling pathway_Homo sapiens_hsa041501.41139411
23Longevity regulating pathway - mammal_Homo sapiens_hsa042111.40267174
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36158328
25AMPK signaling pathway_Homo sapiens_hsa041521.35971980
26Salivary secretion_Homo sapiens_hsa049701.31441929
27Inositol phosphate metabolism_Homo sapiens_hsa005621.29648502
28Selenocompound metabolism_Homo sapiens_hsa004501.28373371
29Ether lipid metabolism_Homo sapiens_hsa005651.26880938
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25611701
31Caffeine metabolism_Homo sapiens_hsa002321.25206719
32Thyroid hormone synthesis_Homo sapiens_hsa049181.24215090
33Gastric acid secretion_Homo sapiens_hsa049711.23218722
34Galactose metabolism_Homo sapiens_hsa000521.22677621
35Pentose phosphate pathway_Homo sapiens_hsa000301.22624346
36Lysosome_Homo sapiens_hsa041421.21934437
37Glutathione metabolism_Homo sapiens_hsa004801.20959376
38Bladder cancer_Homo sapiens_hsa052191.18562459
39Adherens junction_Homo sapiens_hsa045201.18483493
40Osteoclast differentiation_Homo sapiens_hsa043801.17516243
41Insulin signaling pathway_Homo sapiens_hsa049101.16445422
42ECM-receptor interaction_Homo sapiens_hsa045121.15203072
43Leishmaniasis_Homo sapiens_hsa051401.14099595
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13404242
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.13240677
46Estrogen signaling pathway_Homo sapiens_hsa049151.13210118
47VEGF signaling pathway_Homo sapiens_hsa043701.12336804
48Choline metabolism in cancer_Homo sapiens_hsa052311.12269027
49Pertussis_Homo sapiens_hsa051331.10335011
50N-Glycan biosynthesis_Homo sapiens_hsa005101.09828593
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09413485
52Protein digestion and absorption_Homo sapiens_hsa049741.07795202
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05954245
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05918499
55Central carbon metabolism in cancer_Homo sapiens_hsa052301.04715101
56Tight junction_Homo sapiens_hsa045301.02756114
57Amoebiasis_Homo sapiens_hsa051461.01737576
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01369621
59Hepatitis C_Homo sapiens_hsa051601.00769034
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.98400546
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97971922
62beta-Alanine metabolism_Homo sapiens_hsa004100.97325380
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96331585
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.96044692
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94682672
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94627966
67Salmonella infection_Homo sapiens_hsa051320.90457371
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88598692
69Ovarian steroidogenesis_Homo sapiens_hsa049130.86249459
70Bile secretion_Homo sapiens_hsa049760.85713005
71Renin-angiotensin system_Homo sapiens_hsa046140.84534326
72Retinol metabolism_Homo sapiens_hsa008300.84526743
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83818684
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83235386
75Pancreatic secretion_Homo sapiens_hsa049720.83094214
76Sphingolipid metabolism_Homo sapiens_hsa006000.81770767
77TGF-beta signaling pathway_Homo sapiens_hsa043500.81092526
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80374228
79ErbB signaling pathway_Homo sapiens_hsa040120.79749287
80Sulfur relay system_Homo sapiens_hsa041220.79561115
81Hippo signaling pathway_Homo sapiens_hsa043900.79538357
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77179603
83Vitamin digestion and absorption_Homo sapiens_hsa049770.75039164
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74871920
85Prolactin signaling pathway_Homo sapiens_hsa049170.74741302
86Platelet activation_Homo sapiens_hsa046110.74677065
87Toxoplasmosis_Homo sapiens_hsa051450.72621697
88Glucagon signaling pathway_Homo sapiens_hsa049220.71503563
89Tuberculosis_Homo sapiens_hsa051520.70913214
90TNF signaling pathway_Homo sapiens_hsa046680.69592486
91Non-small cell lung cancer_Homo sapiens_hsa052230.69443818
92Dilated cardiomyopathy_Homo sapiens_hsa054140.68754406
93Prostate cancer_Homo sapiens_hsa052150.68559007
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.68364566
95Arginine biosynthesis_Homo sapiens_hsa002200.68350561
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67733502
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67663210
98Influenza A_Homo sapiens_hsa051640.65460921
99Vibrio cholerae infection_Homo sapiens_hsa051100.64975181
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63263125
101Pancreatic cancer_Homo sapiens_hsa052120.61839039
102Acute myeloid leukemia_Homo sapiens_hsa052210.61061405
103Axon guidance_Homo sapiens_hsa043600.60297659
104Protein export_Homo sapiens_hsa030600.59889283
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59866698
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.59812712
107Thyroid cancer_Homo sapiens_hsa052160.59402057
108PPAR signaling pathway_Homo sapiens_hsa033200.58504967
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58392671
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.57981596
111Renal cell carcinoma_Homo sapiens_hsa052110.57627504
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.56870014
113Focal adhesion_Homo sapiens_hsa045100.56176471
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.55165942
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55156173
116GnRH signaling pathway_Homo sapiens_hsa049120.54526141
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54060089
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53578341
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53184709
120Renin secretion_Homo sapiens_hsa049240.53018196
121Rap1 signaling pathway_Homo sapiens_hsa040150.51821612
122Arginine and proline metabolism_Homo sapiens_hsa003300.50919188
123Cocaine addiction_Homo sapiens_hsa050300.50418145
124Small cell lung cancer_Homo sapiens_hsa052220.48991062
125Linoleic acid metabolism_Homo sapiens_hsa005910.48944469
126Lysine degradation_Homo sapiens_hsa003100.48649535
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48413610
128Circadian rhythm_Homo sapiens_hsa047100.47351009
129Endometrial cancer_Homo sapiens_hsa052130.46347839
130Proteoglycans in cancer_Homo sapiens_hsa052050.45628632
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.45484228
132Malaria_Homo sapiens_hsa051440.45273450
133Starch and sucrose metabolism_Homo sapiens_hsa005000.45269235
134Chronic myeloid leukemia_Homo sapiens_hsa052200.45265989
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45115614
136Endocytosis_Homo sapiens_hsa041440.45002711
137Collecting duct acid secretion_Homo sapiens_hsa049660.43226689
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42985397
139Insulin resistance_Homo sapiens_hsa049310.42273152
140Calcium signaling pathway_Homo sapiens_hsa040200.41773802
141Fat digestion and absorption_Homo sapiens_hsa049750.41517101
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41233609
143Melanogenesis_Homo sapiens_hsa049160.39418741
144Insulin secretion_Homo sapiens_hsa049110.38946885
145Fatty acid biosynthesis_Homo sapiens_hsa000610.38558665
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38288260

Most similar genes based on co-expression Upload to Enrichr

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