MLST8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)5.33529653
2proline biosynthetic process (GO:0006561)5.19434399
3positive regulation of synapse maturation (GO:0090129)5.08205424
4DNA unwinding involved in DNA replication (GO:0006268)4.59043519
5regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.46750595
6L-serine metabolic process (GO:0006563)4.14988224
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.06190799
8regulation of translational fidelity (GO:0006450)4.00633368
9deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.99953181
10positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.88073452
11sodium ion export (GO:0071436)3.80973212
12ribosomal small subunit biogenesis (GO:0042274)3.80789567
13protein localization to kinetochore (GO:0034501)3.78963656
14synaptic vesicle docking involved in exocytosis (GO:0016081)3.78255953
15synaptic vesicle maturation (GO:0016188)3.72565364
16DNA strand renaturation (GO:0000733)3.72033296
17negative regulation of microtubule polymerization (GO:0031115)3.66675792
18negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.66665163
19regulation of mammary gland epithelial cell proliferation (GO:0033599)3.63929224
20proline metabolic process (GO:0006560)3.60714847
21pseudouridine synthesis (GO:0001522)3.60188142
22protein retention in ER lumen (GO:0006621)3.58930875
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.58734430
24peptidyl-arginine omega-N-methylation (GO:0035247)3.57896315
25locomotory exploration behavior (GO:0035641)3.57584037
26cellular potassium ion homeostasis (GO:0030007)3.56035287
27regulation of mitochondrial translation (GO:0070129)3.54383798
28gonadal mesoderm development (GO:0007506)3.51037242
29ribosome biogenesis (GO:0042254)3.49182925
30folic acid metabolic process (GO:0046655)3.48730852
31peptidyl-histidine modification (GO:0018202)3.46557453
32guanosine-containing compound biosynthetic process (GO:1901070)3.44570695
33pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.43832132
34peptidyl-arginine N-methylation (GO:0035246)3.43524282
35peptidyl-arginine methylation (GO:0018216)3.43524282
36nucleobase biosynthetic process (GO:0046112)3.43518272
37base-excision repair, AP site formation (GO:0006285)3.38038231
38adenine nucleotide transport (GO:0051503)3.37452752
39spliceosomal tri-snRNP complex assembly (GO:0000244)3.36646365
40protein maturation by protein folding (GO:0022417)3.35865818
41regulation of translational termination (GO:0006449)3.35824060
42metallo-sulfur cluster assembly (GO:0031163)3.34681227
43iron-sulfur cluster assembly (GO:0016226)3.34681227
44synaptic vesicle exocytosis (GO:0016079)3.34461046
45pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.32735268
46DNA strand elongation involved in DNA replication (GO:0006271)3.31992698
47ribonucleoprotein complex biogenesis (GO:0022613)3.25461795
48pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.24779278
49protein targeting to mitochondrion (GO:0006626)3.21537644
50negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.21252317
51layer formation in cerebral cortex (GO:0021819)3.21069669
52maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.20350279
53mitotic sister chromatid segregation (GO:0000070)3.20197439
54rRNA modification (GO:0000154)3.18584262
55UTP biosynthetic process (GO:0006228)3.15811455
56protein localization to chromosome, centromeric region (GO:0071459)3.14853303
57histone arginine methylation (GO:0034969)3.12738859
58oxidative phosphorylation (GO:0006119)3.09227495
59DNA strand elongation (GO:0022616)3.08925223
60chaperone-mediated protein transport (GO:0072321)3.08549863
61positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.08021226
62sister chromatid segregation (GO:0000819)3.07949072
63mitochondrial fusion (GO:0008053)3.07284102
64purine nucleobase biosynthetic process (GO:0009113)3.07053963
65pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.05465303
66rRNA transcription (GO:0009303)3.05276539
67regulation of synapse maturation (GO:0090128)3.04824195
68CTP metabolic process (GO:0046036)3.01924968
69CTP biosynthetic process (GO:0006241)3.01924968
70establishment of protein localization to mitochondrion (GO:0072655)3.01321387
71exploration behavior (GO:0035640)3.01320254
72pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.01265569
73nucleobase-containing small molecule interconversion (GO:0015949)2.99448218
74regulation of synaptic vesicle exocytosis (GO:2000300)2.96212928
752-deoxyribonucleotide biosynthetic process (GO:0009265)2.95961649
76deoxyribose phosphate biosynthetic process (GO:0046385)2.95961649
77termination of RNA polymerase III transcription (GO:0006386)2.93437925
78transcription elongation from RNA polymerase III promoter (GO:0006385)2.93437925
79pyrimidine nucleotide catabolic process (GO:0006244)2.91427680
80NADH metabolic process (GO:0006734)2.91156402
81negative regulation of cell aging (GO:0090344)2.91149443
82negative regulation of RNA splicing (GO:0033119)2.88099883
83serine family amino acid biosynthetic process (GO:0009070)2.87657883
84tRNA modification (GO:0006400)2.87424168
85DNA replication initiation (GO:0006270)2.85588021
86formation of translation preinitiation complex (GO:0001731)2.85566548
87regulation of NFAT protein import into nucleus (GO:0051532)2.84780969
88UTP metabolic process (GO:0046051)2.84540552
89nucleotide salvage (GO:0043173)2.84479893
90protein complex localization (GO:0031503)2.83671477
91positive regulation of RNA splicing (GO:0033120)2.83328965
92GTP biosynthetic process (GO:0006183)2.82687198
93folic acid-containing compound biosynthetic process (GO:0009396)2.81492321
94protein localization to synapse (GO:0035418)2.81324457
95positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80768395
96regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.80501256
97glutamate secretion (GO:0014047)2.80486099
98tRNA methylation (GO:0030488)2.79998746
99nuclear envelope reassembly (GO:0031468)2.79440472
100mitotic nuclear envelope reassembly (GO:0007084)2.79440472
101purine ribonucleotide transport (GO:0015868)2.79408487
102cellular component biogenesis (GO:0044085)2.78392685
103kinetochore assembly (GO:0051382)2.77307470
104gluconeogenesis (GO:0006094)2.77022274
105GMP metabolic process (GO:0046037)2.76503840
106monosaccharide biosynthetic process (GO:0046364)2.76154624
107mitotic spindle organization (GO:0007052)2.75929083
108UV protection (GO:0009650)2.75666904
109transcription from mitochondrial promoter (GO:0006390)2.74800225
110regulation of synapse structural plasticity (GO:0051823)2.74596601
111DNA replication checkpoint (GO:0000076)2.73443832
112CDP-diacylglycerol metabolic process (GO:0046341)2.70502209
113mitochondrial RNA metabolic process (GO:0000959)2.70360030
114tRNA aminoacylation for protein translation (GO:0006418)2.69413360
115IMP biosynthetic process (GO:0006188)2.69122440
116purine nucleotide transport (GO:0015865)2.69100259
117hexose biosynthetic process (GO:0019319)2.68761337
118mitotic nuclear envelope disassembly (GO:0007077)2.68507997
119deoxyribonucleotide catabolic process (GO:0009264)2.68506562
120protein insertion into membrane (GO:0051205)2.68336309
121tRNA aminoacylation (GO:0043039)2.68186087
122amino acid activation (GO:0043038)2.68186087
123telomere maintenance via semi-conservative replication (GO:0032201)2.68113648
124negative regulation of mRNA processing (GO:0050686)2.68001375
125mitotic chromosome condensation (GO:0007076)2.66859783
126histone-serine phosphorylation (GO:0035404)2.66681536
127base-excision repair (GO:0006284)2.66449798
128pentose metabolic process (GO:0019321)2.66391979
129rRNA processing (GO:0006364)2.65721763
130regulation of spindle organization (GO:0090224)2.65631686
131protein localization to mitochondrion (GO:0070585)2.64883600
132cullin deneddylation (GO:0010388)2.64558639
133mitotic G1 DNA damage checkpoint (GO:0031571)2.63992133
134proteasome assembly (GO:0043248)2.63161092
135positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62441217
136nucleoside salvage (GO:0043174)2.61687849
137glucocorticoid receptor signaling pathway (GO:0042921)2.59313653
138COPI coating of Golgi vesicle (GO:0048205)2.59096686
139Golgi transport vesicle coating (GO:0048200)2.59096686
140nuclear envelope disassembly (GO:0051081)2.58831136
141membrane disassembly (GO:0030397)2.58831136
142mRNA splicing, via spliceosome (GO:0000398)2.58655190
143RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.58655190
144spliceosomal snRNP assembly (GO:0000387)2.58367075
145DNA replication-dependent nucleosome assembly (GO:0006335)2.58293645
146DNA replication-dependent nucleosome organization (GO:0034723)2.58293645
147pentose-phosphate shunt (GO:0006098)2.55724869
148translesion synthesis (GO:0019985)2.55418849
149regulation of nucleobase-containing compound transport (GO:0032239)2.54755486
150RNA splicing, via transesterification reactions (GO:0000375)2.53664201
151mitotic spindle assembly checkpoint (GO:0007094)2.53171780
152regulation of RNA export from nucleus (GO:0046831)2.50680586
153regulation of synaptic vesicle transport (GO:1902803)2.49432407
154DNA duplex unwinding (GO:0032508)2.47817579
155pre-miRNA processing (GO:0031054)2.47675109
156cytoskeletal anchoring at plasma membrane (GO:0007016)2.47502496
157synaptic transmission, glutamatergic (GO:0035249)2.47062796
158spindle assembly checkpoint (GO:0071173)2.46820589
159regulation of telomere maintenance via telomerase (GO:0032210)2.46600801
160negative regulation of chromosome segregation (GO:0051985)2.46440026
161regulation of chromosome segregation (GO:0051983)2.45175458
162cell communication by electrical coupling (GO:0010644)2.44253275
163cell migration in hindbrain (GO:0021535)2.42659662
164DNA geometric change (GO:0032392)2.42158181
165alternative mRNA splicing, via spliceosome (GO:0000380)2.41193142
166neurotransmitter secretion (GO:0007269)2.40819883
167negative regulation of mitotic sister chromatid separation (GO:2000816)2.40603532
168negative regulation of mitotic sister chromatid segregation (GO:0033048)2.40603532
169negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.40603532
170negative regulation of sister chromatid segregation (GO:0033046)2.40603532
171negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.39502137
172nucleosome disassembly (GO:0006337)2.39166748
173protein-DNA complex disassembly (GO:0032986)2.39166748
174positive regulation of chromosome segregation (GO:0051984)2.39109537
175vocalization behavior (GO:0071625)2.37633199
176pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.36520170
177protein localization to chromosome (GO:0034502)2.36223489
178regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.35974832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.82695404
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.28799259
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.78319857
4MYC_22102868_ChIP-Seq_BL_Human3.03050345
5CIITA_25753668_ChIP-Seq_RAJI_Human2.60809839
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53937033
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.53236792
8THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36410358
9* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.16764778
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.14917512
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.14638009
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11185419
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07537888
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05216092
15VDR_21846776_ChIP-Seq_THP-1_Human2.04714214
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04333648
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00936258
18* XRN2_22483619_ChIP-Seq_HELA_Human1.95921221
19ZFP281_18757296_ChIP-ChIP_E14_Mouse1.89527780
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85581755
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.78552780
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78314528
23SRY_22984422_ChIP-ChIP_TESTIS_Rat1.77750071
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76909501
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75758134
26GABP_19822575_ChIP-Seq_HepG2_Human1.73908211
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73861052
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70949632
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68622483
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.67904857
31CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.64634689
32RACK7_27058665_Chip-Seq_MCF-7_Human1.64525782
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63405589
34CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.62456549
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.62399233
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61933639
37KDM2B_26808549_Chip-Seq_DND41_Human1.59301491
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59231678
39LXR_22292898_ChIP-Seq_THP-1_Human1.58598386
40DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.55654355
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53220623
42KDM5A_27292631_Chip-Seq_BREAST_Human1.51616691
43P68_20966046_ChIP-Seq_HELA_Human1.50984969
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.49935412
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49593905
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.49470200
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49374388
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47933913
49TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.43794457
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42830998
51ZNF263_19887448_ChIP-Seq_K562_Human1.42478753
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41862902
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40236508
54SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39165936
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38323827
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38320437
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34920563
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34542175
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34427308
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33463834
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31738378
62* SA1_27219007_Chip-Seq_ERYTHROID_Human1.30849807
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30282768
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29620843
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28686293
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28140123
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.27460564
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27354304
69* FOXP3_21729870_ChIP-Seq_TREG_Human1.27176997
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.26395787
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25968073
72EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25298471
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25206130
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.24877672
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.24810407
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24099059
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23559817
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23471857
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23182141
80VDR_23849224_ChIP-Seq_CD4+_Human1.22491373
81CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22362356
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.22233910
83RARA_24833708_ChIP-Seq_LIVER_Mouse1.20295569
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20211022
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18299794
86ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17920822
87EZH2_22144423_ChIP-Seq_EOC_Human1.17873435
88BCOR_27268052_Chip-Seq_Bcells_Human1.17776772
89UTX_26944678_Chip-Seq_JUKART_Human1.17276670
90CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16115985
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15777270
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15428585
93* MAF_26560356_Chip-Seq_TH2_Human1.15368117
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15026075
95RARB_24833708_ChIP-Seq_LIVER_Mouse1.14842152
96* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14608204
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13658564
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13334693
99YY1_22570637_ChIP-Seq_MALME-3M_Human1.13166294
100CTCF_27219007_Chip-Seq_Bcells_Human1.12251648
101* E2F1_20622854_ChIP-Seq_HELA_Human1.12242248
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12240526
103DCP1A_22483619_ChIP-Seq_HELA_Human1.11724204
104CTCF_21964334_Chip-Seq_Bcells_Human1.11473912
105AR_21909140_ChIP-Seq_LNCAP_Human1.11141140
106BCL6_27268052_Chip-Seq_Bcells_Human1.10965803
107* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10961327
108PHF8_20622854_ChIP-Seq_HELA_Human1.10896253
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10771960
110SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.10696196
111KDM2B_26808549_Chip-Seq_K562_Human1.10642578
112NANOG_21062744_ChIP-ChIP_HESCs_Human1.10166304
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09591308
114CREB1_26743006_Chip-Seq_LNCaP_Human1.08970867
115* FOXP1_21924763_ChIP-Seq_HESCs_Human1.08954892
116EGR1_19374776_ChIP-ChIP_THP-1_Human1.08723757
117TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08414767
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08099985
119* CTCF_26484167_Chip-Seq_Bcells_Mouse1.07953452
120SMC4_20622854_ChIP-Seq_HELA_Human1.07935894
121ELF1_20517297_ChIP-Seq_JURKAT_Human1.06382255
122DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05816429
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05129110
124CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03582187
125KDM2B_26808549_Chip-Seq_JURKAT_Human1.03295772
126IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02286401
127TTF2_22483619_ChIP-Seq_HELA_Human1.01850336
128RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01560792
129E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99594379
130TCF7_22412390_ChIP-Seq_EML_Mouse0.99305889
131TET1_21451524_ChIP-Seq_MESCs_Mouse0.98548700
132E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97254363
133EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96825305
134MAF_26560356_Chip-Seq_TH1_Human0.96019680
135SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95959653
136MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94890324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.04091274
2MP0005171_absent_coat_pigmentation3.19799734
3MP0003111_abnormal_nucleus_morphology2.93827842
4MP0003693_abnormal_embryo_hatching2.81198339
5MP0003635_abnormal_synaptic_transmissio2.69057600
6MP0003303_peritoneal_inflammation2.42982202
7MP0003329_amyloid_beta_deposits2.34356145
8MP0008058_abnormal_DNA_repair2.31842556
9MP0004270_analgesia2.29755757
10MP0004957_abnormal_blastocyst_morpholog2.22989858
11MP0010094_abnormal_chromosome_stability2.15165966
12MP0001730_embryonic_growth_arrest2.07031126
13MP0003806_abnormal_nucleotide_metabolis2.05552864
14MP0002063_abnormal_learning/memory/cond2.02902185
15MP0001346_abnormal_lacrimal_gland2.02397906
16MP0005451_abnormal_body_composition2.01340745
17MP0000678_abnormal_parathyroid_gland2.01023049
18MP0003077_abnormal_cell_cycle2.00380665
19MP0002735_abnormal_chemical_nociception1.98951290
20MP0008057_abnormal_DNA_replication1.98893321
21MP0002822_catalepsy1.96663138
22MP0003880_abnormal_central_pattern1.92269308
23MP0006036_abnormal_mitochondrial_physio1.92072171
24MP0004233_abnormal_muscle_weight1.90947624
25MP0001188_hyperpigmentation1.90336470
26MP0002249_abnormal_larynx_morphology1.88698417
27MP0002064_seizures1.87021813
28MP0005058_abnormal_lysosome_morphology1.81448765
29MP0000750_abnormal_muscle_regeneration1.81396533
30MP0003123_paternal_imprinting1.80224904
31MP0005330_cardiomyopathy1.78450502
32MP0005501_abnormal_skin_physiology1.77752840
33MP0002089_abnormal_postnatal_growth/wei1.76583418
34MP0003136_yellow_coat_color1.73990862
35MP0004811_abnormal_neuron_physiology1.72736909
36MP0008007_abnormal_cellular_replicative1.72580015
37MP0000003_abnormal_adipose_tissue1.71863531
38MP0001968_abnormal_touch/_nociception1.69342641
39MP0009046_muscle_twitch1.65395005
40MP0004858_abnormal_nervous_system1.60172592
41MP0000751_myopathy1.59415634
42MP0002653_abnormal_ependyma_morphology1.59285592
43MP0010352_gastrointestinal_tract_polyps1.56071774
44MP0003786_premature_aging1.54007977
45MP0005076_abnormal_cell_differentiation1.53692034
46MP0009745_abnormal_behavioral_response1.52687929
47MP0006035_abnormal_mitochondrial_morpho1.50949268
48MP0000350_abnormal_cell_proliferation1.50824124
49MP0002160_abnormal_reproductive_system1.48487030
50MP0005083_abnormal_biliary_tract1.46079695
51MP0008260_abnormal_autophagy1.44774616
52MP0002734_abnormal_mechanical_nocicepti1.42561569
53MP0002572_abnormal_emotion/affect_behav1.41168103
54MP0003119_abnormal_digestive_system1.36855247
55MP0002272_abnormal_nervous_system1.33204525
56MP0000747_muscle_weakness1.32007836
57MP0001529_abnormal_vocalization1.31899519
58* MP0002080_prenatal_lethality1.31184401
59MP0008569_lethality_at_weaning1.30066221
60MP0005174_abnormal_tail_pigmentation1.29907668
61MP0001986_abnormal_taste_sensitivity1.29262041
62MP0000313_abnormal_cell_death1.27981869
63MP0003890_abnormal_embryonic-extraembry1.27895927
64MP0003183_abnormal_peptide_metabolism1.27514993
65MP0002909_abnormal_adrenal_gland1.26128930
66MP0005499_abnormal_olfactory_system1.26111045
67MP0005394_taste/olfaction_phenotype1.26111045
68MP0001502_abnormal_circadian_rhythm1.26103538
69MP0002184_abnormal_innervation1.25979791
70MP0008932_abnormal_embryonic_tissue1.24477329
71MP0001440_abnormal_grooming_behavior1.22596043
72MP0002733_abnormal_thermal_nociception1.22025285
73MP0001970_abnormal_pain_threshold1.21739668
74MP0009672_abnormal_birth_weight1.20101748
75MP0005623_abnormal_meninges_morphology1.20018270
76* MP0001697_abnormal_embryo_size1.19108806
77MP0004185_abnormal_adipocyte_glucose1.17814588
78MP0003121_genomic_imprinting1.16393436
79MP0006072_abnormal_retinal_apoptosis1.15926484
80MP0002396_abnormal_hematopoietic_system1.15733547
81MP0005551_abnormal_eye_electrophysiolog1.15357599
82MP0003172_abnormal_lysosome_physiology1.12789924
83MP0003186_abnormal_redox_activity1.11672081
84MP0002067_abnormal_sensory_capabilities1.11325185
85MP0000955_abnormal_spinal_cord1.09398019
86MP0005670_abnormal_white_adipose1.09114279
87MP0004215_abnormal_myocardial_fiber1.08965200
88* MP0005380_embryogenesis_phenotype1.08292985
89* MP0001672_abnormal_embryogenesis/_devel1.08292985
90MP0002736_abnormal_nociception_after1.07100759
91MP0000049_abnormal_middle_ear1.06905088
92* MP0002152_abnormal_brain_morphology1.06678314
93MP0005332_abnormal_amino_acid1.06541256
94MP0003705_abnormal_hypodermis_morpholog1.04698109
95MP0002882_abnormal_neuron_morphology1.04359511
96MP0003656_abnormal_erythrocyte_physiolo1.04194115
97MP0001486_abnormal_startle_reflex1.03152046
98MP0003315_abnormal_perineum_morphology1.02453432
99MP0001348_abnormal_lacrimal_gland0.99655229
100* MP0003861_abnormal_nervous_system0.99571952
101MP0002085_abnormal_embryonic_tissue0.99207725
102MP0008770_decreased_survivor_rate0.97861604
103MP0002269_muscular_atrophy0.97787192
104MP0000428_abnormal_craniofacial_morphol0.97175995
105MP0003787_abnormal_imprinting0.97143691
106MP0000759_abnormal_skeletal_muscle0.95834069
107MP0009780_abnormal_chondrocyte_physiolo0.95144586
108MP0009278_abnormal_bone_marrow0.94478513
109MP0002084_abnormal_developmental_patter0.94456664
110* MP0003984_embryonic_growth_retardation0.94379671
111MP0003453_abnormal_keratinocyte_physiol0.93306042
112MP0003122_maternal_imprinting0.92358820
113MP0002066_abnormal_motor_capabilities/c0.92356364
114MP0001919_abnormal_reproductive_system0.91572518
115MP0000358_abnormal_cell_content/0.90783910
116* MP0002088_abnormal_embryonic_growth/wei0.90564871
117MP0000778_abnormal_nervous_system0.90348238
118MP0000013_abnormal_adipose_tissue0.90095143
119MP0003646_muscle_fatigue0.89315969
120MP0010030_abnormal_orbit_morphology0.88603931
121MP0000604_amyloidosis0.88290748
122MP0005423_abnormal_somatic_nervous0.88165620
123MP0004197_abnormal_fetal_growth/weight/0.88158604
124MP0003879_abnormal_hair_cell0.87805838
125MP0003221_abnormal_cardiomyocyte_apopto0.87600208
126MP0004147_increased_porphyrin_level0.86776607
127MP0000681_abnormal_thyroid_gland0.86385504
128MP0001764_abnormal_homeostasis0.85982897
129MP0005621_abnormal_cell_physiology0.85264772
130MP0000537_abnormal_urethra_morphology0.85022214
131MP0009703_decreased_birth_body0.83670988
132MP0002877_abnormal_melanocyte_morpholog0.82612636
133MP0009840_abnormal_foam_cell0.82039546
134MP0005384_cellular_phenotype0.82027678
135MP0002210_abnormal_sex_determination0.81849452
136MP0005375_adipose_tissue_phenotype0.80097218
137MP0001849_ear_inflammation0.79667689
138MP0005257_abnormal_intraocular_pressure0.79226979
139MP0008875_abnormal_xenobiotic_pharmacok0.78800965
140MP0003634_abnormal_glial_cell0.78414464
141MP0002234_abnormal_pharynx_morphology0.78186291
142MP0002796_impaired_skin_barrier0.77874979
143* MP0002086_abnormal_extraembryonic_tissu0.77476684
144MP0003137_abnormal_impulse_conducting0.76330708
145MP0002557_abnormal_social/conspecific_i0.75457664
146MP0002019_abnormal_tumor_incidence0.69381838
147MP0004087_abnormal_muscle_fiber0.69145299
148MP0001905_abnormal_dopamine_level0.67727153
149MP0001145_abnormal_male_reproductive0.66705441
150MP0001756_abnormal_urination0.65531889
151MP0002111_abnormal_tail_morphology0.64364080
152MP0000538_abnormal_urinary_bladder0.63071748
153MP0005584_abnormal_enzyme/coenzyme_acti0.62236522
154MP0002697_abnormal_eye_size0.60749416
155MP0003942_abnormal_urinary_system0.59984761
156MP0004133_heterotaxia0.58682862
157MP0003718_maternal_effect0.57884977
158MP0005666_abnormal_adipose_tissue0.56570866

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.13504315
2Myokymia (HP:0002411)4.02023390
3Cerebral hypomyelination (HP:0006808)3.74915575
4Visual hallucinations (HP:0002367)3.60716401
5Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.59882475
6Increased intramyocellular lipid droplets (HP:0012240)3.55487989
7Focal motor seizures (HP:0011153)3.49103519
8Increased muscle lipid content (HP:0009058)3.47696660
9Progressive muscle weakness (HP:0003323)3.43772687
10Ankle clonus (HP:0011448)3.40984117
11Ragged-red muscle fibers (HP:0003200)3.39834425
12Ulnar bowing (HP:0003031)3.26757312
13Microvesicular hepatic steatosis (HP:0001414)3.25918627
14Insomnia (HP:0100785)3.19995975
15Abnormality of the lower motor neuron (HP:0002366)3.19946051
16Lipid accumulation in hepatocytes (HP:0006561)3.15535785
17Increased hepatocellular lipid droplets (HP:0006565)3.15191869
18Congenital stationary night blindness (HP:0007642)3.12723965
19Rib fusion (HP:0000902)3.11156742
20Hyperacusis (HP:0010780)3.05163885
21Pelvic girdle muscle weakness (HP:0003749)3.03593106
22Renal Fanconi syndrome (HP:0001994)3.02209017
23Mesangial abnormality (HP:0001966)3.00892565
24Focal seizures (HP:0007359)3.00635099
25Pointed chin (HP:0000307)2.95805947
26Papilledema (HP:0001085)2.87748521
27Shoulder girdle muscle weakness (HP:0003547)2.80605208
28Vaginal fistula (HP:0004320)2.77610263
29Squamous cell carcinoma (HP:0002860)2.77179751
30Poikiloderma (HP:0001029)2.72543808
31Hemiplegia (HP:0002301)2.71261553
32Abnormality of the hip-girdle musculature (HP:0001445)2.71229777
33Abnormality of the musculature of the pelvis (HP:0001469)2.71229777
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.70807787
35Urinary urgency (HP:0000012)2.68236884
36Cholelithiasis (HP:0001081)2.61822058
37Rectovaginal fistula (HP:0000143)2.58269609
38Rectal fistula (HP:0100590)2.58269609
39Truncus arteriosus (HP:0001660)2.57639669
40Ependymoma (HP:0002888)2.57477124
41Abnormality of the astrocytes (HP:0100707)2.57372708
42Astrocytoma (HP:0009592)2.57372708
43Impaired vibration sensation in the lower limbs (HP:0002166)2.53518498
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52579951
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52579951
46Spastic gait (HP:0002064)2.50330905
47Akinesia (HP:0002304)2.48058175
48Turricephaly (HP:0000262)2.47495047
49Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.45970065
50Annular pancreas (HP:0001734)2.41595938
51Amyotrophic lateral sclerosis (HP:0007354)2.40308762
52Abnormality of the intrinsic pathway (HP:0010989)2.39173816
53Impaired smooth pursuit (HP:0007772)2.37816091
54Intestinal fistula (HP:0100819)2.36908270
55Increased serum lactate (HP:0002151)2.35832075
56Abnormal gallbladder physiology (HP:0012438)2.35813377
57Cholecystitis (HP:0001082)2.35813377
58Difficulty climbing stairs (HP:0003551)2.35770196
59Broad distal phalanx of finger (HP:0009836)2.35542786
60Fatigue (HP:0012378)2.35532374
61Abnormal mitochondria in muscle tissue (HP:0008316)2.34126391
62Selective tooth agenesis (HP:0001592)2.33368713
63Exercise intolerance (HP:0003546)2.32585759
64Depression (HP:0000716)2.28337806
65Birth length less than 3rd percentile (HP:0003561)2.28255517
66Abnormal gallbladder morphology (HP:0012437)2.28057968
67Facial hemangioma (HP:0000329)2.26772507
68Mitochondrial inheritance (HP:0001427)2.26621073
69Generalized hypotonia (HP:0001290)2.25322212
70Apathy (HP:0000741)2.23739990
71Thin bony cortex (HP:0002753)2.22031655
72Increased CSF lactate (HP:0002490)2.21670603
73Type I transferrin isoform profile (HP:0003642)2.21250390
74Supranuclear gaze palsy (HP:0000605)2.19906352
75Overriding aorta (HP:0002623)2.19669776
76Diminished motivation (HP:0000745)2.17630272
77Hepatocellular necrosis (HP:0001404)2.17465039
78Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16472016
79Clonus (HP:0002169)2.16431357
80Colon cancer (HP:0003003)2.14950571
81Abnormality of the gallbladder (HP:0005264)2.14154311
82Delayed epiphyseal ossification (HP:0002663)2.13996303
83Dyschromatopsia (HP:0007641)2.13774106
84Hypoplasia of the capital femoral epiphysis (HP:0003090)2.12477924
85Neoplasm of the adrenal cortex (HP:0100641)2.12387267
86Lactic acidosis (HP:0003128)2.11874066
87Neonatal onset (HP:0003623)2.10876740
88Abnormal number of erythroid precursors (HP:0012131)2.10071291
89Respiratory difficulties (HP:0002880)2.09776563
90Progressive external ophthalmoplegia (HP:0000590)2.08456323
91Breast hypoplasia (HP:0003187)2.08185245
92Reduced antithrombin III activity (HP:0001976)2.07746881
93Stridor (HP:0010307)2.07281809
94Truncal ataxia (HP:0002078)2.06531233
95Abnormality of ocular smooth pursuit (HP:0000617)2.05477573
96Delusions (HP:0000746)2.03987065
97Angiofibromas (HP:0010615)2.02791610
98Adenoma sebaceum (HP:0009720)2.02791610
99Increased nuchal translucency (HP:0010880)2.02566559
100Tetraplegia (HP:0002445)2.01052756
101Hemorrhage of the eye (HP:0011885)2.01046792
102Hyperthyroidism (HP:0000836)2.00963622
103Atrophy/Degeneration involving motor neurons (HP:0007373)2.00465757
104Urinary bladder sphincter dysfunction (HP:0002839)2.00448459
105Acute necrotizing encephalopathy (HP:0006965)1.99728587
106Abnormality of cells of the erythroid lineage (HP:0012130)1.98954121
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98895213
108Abnormal protein N-linked glycosylation (HP:0012347)1.98895213
109Abnormal protein glycosylation (HP:0012346)1.98895213
110Abnormal glycosylation (HP:0012345)1.98895213
111Glioma (HP:0009733)1.98785221
112Acute encephalopathy (HP:0006846)1.97762769
113Renal duplication (HP:0000075)1.97096235
114Abnormality of the umbilical cord (HP:0010881)1.97017512
115Megalocornea (HP:0000485)1.96360097
116Impaired social interactions (HP:0000735)1.96042928
117Abnormal social behavior (HP:0012433)1.96042928
118CNS hypomyelination (HP:0003429)1.95967886
119Progressive microcephaly (HP:0000253)1.95523931
120Dialeptic seizures (HP:0011146)1.95364178
121Absence seizures (HP:0002121)1.94790108
122Aplasia of the musculature (HP:0100854)1.94476057
123Hypokinesia (HP:0002375)1.93140533
124Double outlet right ventricle (HP:0001719)1.93106989
125Congenital malformation of the right heart (HP:0011723)1.93106989
126Calcaneovalgus deformity (HP:0001848)1.93052488
127Limb-girdle muscle weakness (HP:0003325)1.92907884
128Hepatic necrosis (HP:0002605)1.92739419
129Elfin facies (HP:0004428)1.91493538
130Postnatal microcephaly (HP:0005484)1.90986163
131Diminished movement (HP:0002374)1.89633388
132Athetosis (HP:0002305)1.89488206
133Hypoplastic heart (HP:0001961)1.89392149
134Abnormality of the labia minora (HP:0012880)1.87563562
135Hand muscle atrophy (HP:0009130)1.87389411
136Absent thumb (HP:0009777)1.86401135
137Abnormality of the calcaneus (HP:0008364)1.85651324
138Patellar aplasia (HP:0006443)1.85059444
139Large hands (HP:0001176)1.84367280
140Abnormal trabecular bone morphology (HP:0100671)1.84044011
141Spastic tetraparesis (HP:0001285)1.83468353
142Opisthotonus (HP:0002179)1.83448658
143Abnormality of pain sensation (HP:0010832)1.82474733
144Impaired pain sensation (HP:0007328)1.82474733
145Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82215820
146Abnormality of alanine metabolism (HP:0010916)1.82215820
147Hyperalaninemia (HP:0003348)1.82215820
148Reticulocytopenia (HP:0001896)1.81610194
149Neoplasm of the heart (HP:0100544)1.81361114
150Poor eye contact (HP:0000817)1.78595415
151Global brain atrophy (HP:0002283)1.78560252
152Multiple enchondromatosis (HP:0005701)1.78537848
153Atrioventricular block (HP:0001678)1.77759977
154Emotional lability (HP:0000712)1.77753019
155Oral leukoplakia (HP:0002745)1.77672609
156Limb-girdle muscle atrophy (HP:0003797)1.76840041
157Abnormalities of placenta or umbilical cord (HP:0001194)1.75363578
158Abnormality of oral frenula (HP:0000190)1.75308478
159Aplasia/Hypoplasia of the patella (HP:0006498)1.75255377
160Dysmetric saccades (HP:0000641)1.74936688
161Distal upper limb amyotrophy (HP:0007149)1.73856797
162Upper limb amyotrophy (HP:0009129)1.73856797
163Action tremor (HP:0002345)1.73044311
164Cortical visual impairment (HP:0100704)1.72973827
165Myopathic facies (HP:0002058)1.72751052
166Anteriorly placed anus (HP:0001545)1.72535445
167Absent radius (HP:0003974)1.72049238
168Rough bone trabeculation (HP:0100670)1.71783075
169Epileptic encephalopathy (HP:0200134)1.71214712
170Cortical dysplasia (HP:0002539)1.71013575
171Premature graying of hair (HP:0002216)1.70865051
172External ophthalmoplegia (HP:0000544)1.70855342
173Termporal pattern (HP:0011008)1.70691836
174Insidious onset (HP:0003587)1.70691836
175Choanal stenosis (HP:0000452)1.70198393
176Aplasia/Hypoplasia of the brainstem (HP:0007362)1.69841525
177Hypoplasia of the brainstem (HP:0002365)1.69841525
178Deformed tarsal bones (HP:0008119)1.69715966
179Microretrognathia (HP:0000308)1.68302022
180Abnormality of the motor neurons (HP:0002450)1.68188171
181Abnormal neuron morphology (HP:0012757)1.68188171
182Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68148272
183Abnormality of glycolysis (HP:0004366)1.67846993
184Increased serum pyruvate (HP:0003542)1.67846993
185Hepatoblastoma (HP:0002884)1.67161126

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.40778265
2NEK13.96259619
3MAP3K93.46601177
4VRK23.09630284
5TRIB32.98781742
6SMG12.96117423
7BCKDK2.88565109
8BUB12.48606464
9CDC72.33990671
10RIPK12.33662463
11EEF2K2.20279800
12IRAK32.12090619
13NEK22.07202449
14EPHA42.00752296
15STK162.00503072
16TSSK62.00440754
17MAPK152.00248799
18FES1.93347209
19PIM21.90950665
20WEE11.85854836
21PAK61.83062893
22TESK21.82946609
23CCNB11.80409663
24ACVR1B1.74040036
25TYRO31.73780212
26KSR21.73086634
27MARK11.65016093
28NTRK31.62553876
29SIK11.61176388
30CAMKK11.59370706
31ALK1.53031896
32BRSK11.51030584
33MINK11.50023988
34PRKD31.41488841
35PHKG11.40125868
36PHKG21.40125868
37TAOK21.40052799
38BRAF1.38295701
39KSR11.35392004
40ZAK1.33746696
41PDK21.31354669
42PKN21.24645957
43LRRK21.23993812
44DAPK11.19548587
45NME11.19211880
46EPHA21.16409312
47CHEK21.13717873
48WNK41.10991229
49CDK151.09715849
50CDK181.09161747
51ICK1.08318087
52PDGFRA1.07852759
53CDK11A1.03675211
54TLK11.01976671
55GRK61.01735840
56UHMK10.99764803
57AKT20.99157142
58IRAK20.97753010
59TTK0.97722120
60MAP3K40.95271277
61CDK140.95137436
62MUSK0.92068886
63MAP3K100.89920554
64NTRK20.89387338
65BRSK20.89232624
66TAOK10.88360000
67PLK10.86795658
68ARAF0.85754590
69SIK20.85376838
70KDR0.84948664
71ABL20.83257751
72NTRK10.82681224
73ILK0.80505843
74SCYL20.79335115
75CHEK10.78979496
76BMX0.78531240
77MAP4K10.77812542
78EIF2AK10.77664416
79MAP3K80.76938958
80PRKD20.75561790
81FGFR10.75459330
82TTN0.75200266
83MAP3K120.72400401
84PAK40.71167186
85LMTK20.71104671
86ATR0.69410117
87DDR20.69181506
88CAMKK20.68662821
89FER0.66735031
90PDPK10.66284773
91CDK80.65984904
92CDK50.65584864
93CDK70.63279546
94PRKCI0.62871745
95TESK10.61358426
96RET0.61225619
97MAPK110.60991560
98PRKCG0.60873234
99MAP2K30.60863024
100MTOR0.60690573
101DAPK20.58560068
102MAP3K110.57181001
103CAMK1D0.56835275
104PASK0.56479906
105CSNK1G30.56332717
106CSNK1A1L0.56200316
107STK100.55511910
108DAPK30.55082469
109CDK20.54658325
110CDK40.54605463
111PTK60.54421164
112CSNK1G20.52663830
113CDK190.51623741
114PBK0.50734553
115DYRK20.50123642
116MAP2K20.49323306
117PLK30.48987996
118SRPK10.48303999
119PNCK0.47693140
120CDK120.47463649
121AURKB0.47315039
122PRPF4B0.46799567
123MST1R0.46041955
124CDK10.45146987
125ERBB30.45110367
126RAF10.45020259
127PAK30.44970565
128ERN10.44405125
129LIMK10.44348042
130DYRK1B0.43583093
131CAMK2G0.43502218
132CSNK1E0.42732917
133MAP3K60.42291406
134VRK10.42014000
135RPS6KB20.42013859
136RPS6KA20.40719890
137STK380.40343567
138AURKA0.38762410
139RPS6KA50.38664452
140PAK10.37984973
141MAPK90.37189967
142CSNK1G10.34783483
143MAPKAPK30.34635495

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.41314967
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.14166484
3DNA replication_Homo sapiens_hsa030302.88159988
4Ribosome_Homo sapiens_hsa030102.50532381
5Synaptic vesicle cycle_Homo sapiens_hsa047212.45435613
6Spliceosome_Homo sapiens_hsa030402.21689810
7Mismatch repair_Homo sapiens_hsa034302.19885494
8Vitamin B6 metabolism_Homo sapiens_hsa007502.17004964
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.05992281
10RNA transport_Homo sapiens_hsa030131.93626894
11Base excision repair_Homo sapiens_hsa034101.92007079
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89333652
13Oocyte meiosis_Homo sapiens_hsa041141.88527431
14Cell cycle_Homo sapiens_hsa041101.81035062
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.79649901
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68314788
17Pyruvate metabolism_Homo sapiens_hsa006201.65271963
18Nicotine addiction_Homo sapiens_hsa050331.64989132
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62212751
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.60631351
21Oxidative phosphorylation_Homo sapiens_hsa001901.59329585
22Olfactory transduction_Homo sapiens_hsa047401.58343017
23Biosynthesis of amino acids_Homo sapiens_hsa012301.57284606
24Long-term potentiation_Homo sapiens_hsa047201.56725932
25GABAergic synapse_Homo sapiens_hsa047271.56461666
26Parkinsons disease_Homo sapiens_hsa050121.50800209
27* mTOR signaling pathway_Homo sapiens_hsa041501.50603856
28Circadian entrainment_Homo sapiens_hsa047131.49418219
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47549884
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45732737
31mRNA surveillance pathway_Homo sapiens_hsa030151.43022421
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40986540
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.40208066
34Homologous recombination_Homo sapiens_hsa034401.39847943
35Fatty acid elongation_Homo sapiens_hsa000621.38340497
36Morphine addiction_Homo sapiens_hsa050321.36619526
37Dopaminergic synapse_Homo sapiens_hsa047281.35310312
38Proteasome_Homo sapiens_hsa030501.34312014
39Pentose phosphate pathway_Homo sapiens_hsa000301.33747784
40Folate biosynthesis_Homo sapiens_hsa007901.32915877
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32903410
42Arginine and proline metabolism_Homo sapiens_hsa003301.30420347
43Glutamatergic synapse_Homo sapiens_hsa047241.27715215
44Phototransduction_Homo sapiens_hsa047441.27375813
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25509911
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22416560
47Huntingtons disease_Homo sapiens_hsa050161.21189472
48Galactose metabolism_Homo sapiens_hsa000521.19182652
49Cholinergic synapse_Homo sapiens_hsa047251.16740918
50Fanconi anemia pathway_Homo sapiens_hsa034601.15658296
51Non-homologous end-joining_Homo sapiens_hsa034501.14743325
52Gap junction_Homo sapiens_hsa045401.14631109
53RNA polymerase_Homo sapiens_hsa030201.12410640
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11662410
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09696495
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.09188055
57Colorectal cancer_Homo sapiens_hsa052101.08421449
58Glutathione metabolism_Homo sapiens_hsa004801.05295845
59Glioma_Homo sapiens_hsa052141.04984343
60Carbon metabolism_Homo sapiens_hsa012001.00638914
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00342852
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00157148
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99933505
64Arginine biosynthesis_Homo sapiens_hsa002200.99430350
65Fructose and mannose metabolism_Homo sapiens_hsa000510.99284587
66Gastric acid secretion_Homo sapiens_hsa049710.98681923
67Non-small cell lung cancer_Homo sapiens_hsa052230.97763874
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.96520981
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94398143
70Amphetamine addiction_Homo sapiens_hsa050310.92955073
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.91905616
72Long-term depression_Homo sapiens_hsa047300.91286250
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91265908
74Insulin secretion_Homo sapiens_hsa049110.91034018
75Alzheimers disease_Homo sapiens_hsa050100.89821520
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89514009
77Estrogen signaling pathway_Homo sapiens_hsa049150.88877732
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88421939
79Nucleotide excision repair_Homo sapiens_hsa034200.85381392
80Oxytocin signaling pathway_Homo sapiens_hsa049210.83991243
81Alcoholism_Homo sapiens_hsa050340.81761478
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81125436
83GnRH signaling pathway_Homo sapiens_hsa049120.80354693
84Vibrio cholerae infection_Homo sapiens_hsa051100.80243620
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79180662
86Other glycan degradation_Homo sapiens_hsa005110.78537072
87Type II diabetes mellitus_Homo sapiens_hsa049300.78439230
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78438410
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77702572
90Epstein-Barr virus infection_Homo sapiens_hsa051690.75973153
91Insulin signaling pathway_Homo sapiens_hsa049100.75669452
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75572376
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75338320
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75051962
95Metabolic pathways_Homo sapiens_hsa011000.74879583
96VEGF signaling pathway_Homo sapiens_hsa043700.74852196
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74794459
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72946859
99Endometrial cancer_Homo sapiens_hsa052130.72887998
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.72833833
101Fatty acid metabolism_Homo sapiens_hsa012120.72600685
102Bladder cancer_Homo sapiens_hsa052190.70834759
103Inositol phosphate metabolism_Homo sapiens_hsa005620.70829603
104Salivary secretion_Homo sapiens_hsa049700.70219015
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69135602
106ErbB signaling pathway_Homo sapiens_hsa040120.67966428
107N-Glycan biosynthesis_Homo sapiens_hsa005100.67794179
108Endocytosis_Homo sapiens_hsa041440.67611184
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65157662
110Phenylalanine metabolism_Homo sapiens_hsa003600.64473810
111Chronic myeloid leukemia_Homo sapiens_hsa052200.62934380
112One carbon pool by folate_Homo sapiens_hsa006700.61296717
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60622555
114AMPK signaling pathway_Homo sapiens_hsa041520.57890159
115Glucagon signaling pathway_Homo sapiens_hsa049220.57607414
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.57021467
117Pyrimidine metabolism_Homo sapiens_hsa002400.56143134
118Purine metabolism_Homo sapiens_hsa002300.55109086
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54684552
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.52627390
121Steroid biosynthesis_Homo sapiens_hsa001000.51846731
122Lysine degradation_Homo sapiens_hsa003100.50410821
123Shigellosis_Homo sapiens_hsa051310.49369180
124HIF-1 signaling pathway_Homo sapiens_hsa040660.49196988
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49059853
126Selenocompound metabolism_Homo sapiens_hsa004500.48874967
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.47947444
128HTLV-I infection_Homo sapiens_hsa051660.47800128
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47027958
130Viral carcinogenesis_Homo sapiens_hsa052030.46902575
131Choline metabolism in cancer_Homo sapiens_hsa052310.45331773
132Basal transcription factors_Homo sapiens_hsa030220.44126023
133Cocaine addiction_Homo sapiens_hsa050300.43743705
134Cardiac muscle contraction_Homo sapiens_hsa042600.43415832
135Pancreatic cancer_Homo sapiens_hsa052120.43335217
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42956081
137RNA degradation_Homo sapiens_hsa030180.41570858
138Viral myocarditis_Homo sapiens_hsa054160.40059972
139Sulfur metabolism_Homo sapiens_hsa009200.39579383
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39462540
141Sphingolipid metabolism_Homo sapiens_hsa006000.36727285
142Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35077614
143Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29073572
144Notch signaling pathway_Homo sapiens_hsa043300.28618941
145Lysosome_Homo sapiens_hsa041420.26959374
146Basal cell carcinoma_Homo sapiens_hsa052170.26297483
147Hedgehog signaling pathway_Homo sapiens_hsa043400.25501263
148p53 signaling pathway_Homo sapiens_hsa041150.24774358
149Tyrosine metabolism_Homo sapiens_hsa003500.24064864
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23167634
151Hippo signaling pathway_Homo sapiens_hsa043900.21523019
152Collecting duct acid secretion_Homo sapiens_hsa049660.18946804
153Peroxisome_Homo sapiens_hsa041460.17020364

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