MLX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.19816961
2L-phenylalanine catabolic process (GO:0006559)4.19816961
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.17699870
4L-phenylalanine metabolic process (GO:0006558)4.17699870
5aldehyde catabolic process (GO:0046185)3.88295705
6signal peptide processing (GO:0006465)3.83691348
7cysteine metabolic process (GO:0006534)3.78074610
8Golgi transport vesicle coating (GO:0048200)3.72714857
9COPI coating of Golgi vesicle (GO:0048205)3.72714857
10intestinal cholesterol absorption (GO:0030299)3.61281902
11aromatic amino acid family catabolic process (GO:0009074)3.48397727
12proteasome assembly (GO:0043248)3.39593300
13protein maturation by protein folding (GO:0022417)3.38306777
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.37926578
15GDP-mannose metabolic process (GO:0019673)3.36239890
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.32544182
17regulation of mitochondrial translation (GO:0070129)3.25259406
18lysine metabolic process (GO:0006553)3.18638732
19lysine catabolic process (GO:0006554)3.18638732
20oxaloacetate metabolic process (GO:0006107)3.14858375
21intestinal absorption (GO:0050892)3.13669197
22sulfur amino acid catabolic process (GO:0000098)3.12573338
23energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10745491
24ATP synthesis coupled proton transport (GO:0015986)3.10745491
25regulation of cholesterol esterification (GO:0010872)3.08368964
26disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.07490789
27killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.07490789
28neutrophil activation involved in immune response (GO:0002283)3.07479858
29alpha-linolenic acid metabolic process (GO:0036109)3.06036865
30valine metabolic process (GO:0006573)3.05220332
31NADH metabolic process (GO:0006734)3.04743680
32regulation of oxidative phosphorylation (GO:0002082)3.03357968
33pteridine-containing compound biosynthetic process (GO:0042559)3.00657135
34branched-chain amino acid catabolic process (GO:0009083)2.98727802
35bile acid biosynthetic process (GO:0006699)2.94382321
36negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.94144070
37glyoxylate metabolic process (GO:0046487)2.91733359
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.88767008
39response to misfolded protein (GO:0051788)2.86713472
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.86433237
41tryptophan metabolic process (GO:0006568)2.85399031
42cotranslational protein targeting to membrane (GO:0006613)2.85155603
43protein targeting to ER (GO:0045047)2.82309080
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.80520186
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.80520186
46disruption of cells of other organism (GO:0044364)2.79984846
47killing of cells of other organism (GO:0031640)2.79984846
48oxidative phosphorylation (GO:0006119)2.79969735
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.79554285
50cofactor catabolic process (GO:0051187)2.79298118
51branched-chain amino acid metabolic process (GO:0009081)2.79151791
52folic acid-containing compound biosynthetic process (GO:0009396)2.78687166
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.78326077
54protein localization to endoplasmic reticulum (GO:0070972)2.77482641
55protein-lipid complex remodeling (GO:0034368)2.76840171
56macromolecular complex remodeling (GO:0034367)2.76840171
57plasma lipoprotein particle remodeling (GO:0034369)2.76840171
58activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.76180651
59tryptophan catabolic process (GO:0006569)2.76163196
60indole-containing compound catabolic process (GO:0042436)2.76163196
61indolalkylamine catabolic process (GO:0046218)2.76163196
62glycosphingolipid catabolic process (GO:0046479)2.75933876
63coenzyme catabolic process (GO:0009109)2.75932419
64high-density lipoprotein particle remodeling (GO:0034375)2.74734763
65drug transmembrane transport (GO:0006855)2.71853592
66serine family amino acid metabolic process (GO:0009069)2.69493671
67regulation of triglyceride catabolic process (GO:0010896)2.69434107
68protein carboxylation (GO:0018214)2.69073846
69peptidyl-glutamic acid carboxylation (GO:0017187)2.69073846
70protoporphyrinogen IX biosynthetic process (GO:0006782)2.68689124
71ribosomal small subunit assembly (GO:0000028)2.68436586
72aromatic amino acid family metabolic process (GO:0009072)2.68197349
73antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.67745397
74protein deneddylation (GO:0000338)2.67160736
75response to nitrosative stress (GO:0051409)2.65718379
76homocysteine metabolic process (GO:0050667)2.65491838
77rRNA modification (GO:0000154)2.65382097
78amino acid salvage (GO:0043102)2.65307773
79L-methionine salvage (GO:0071267)2.65307773
80L-methionine biosynthetic process (GO:0071265)2.65307773
81establishment of protein localization to endoplasmic reticulum (GO:0072599)2.64796245
82serine family amino acid biosynthetic process (GO:0009070)2.64615172
83DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63765529
84kynurenine metabolic process (GO:0070189)2.63234955
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60201898
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60049796
87negative regulation of ligase activity (GO:0051352)2.60049796
88glycolipid catabolic process (GO:0019377)2.59848075
89bile acid and bile salt transport (GO:0015721)2.59650312
90drug transport (GO:0015893)2.58658170
91misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.58134054
92proline biosynthetic process (GO:0006561)2.57930973
93sulfur amino acid metabolic process (GO:0000096)2.57914556
94regulation of superoxide anion generation (GO:0032928)2.56992190
95urea metabolic process (GO:0019627)2.56860499
96urea cycle (GO:0000050)2.56860499
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.56591509
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.56591509
99bile acid metabolic process (GO:0008206)2.56262512
100glycine metabolic process (GO:0006544)2.56037077
101tyrosine metabolic process (GO:0006570)2.55888319
102positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.55760634
103urate metabolic process (GO:0046415)2.55025535
104antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.54765252
105alpha-amino acid catabolic process (GO:1901606)2.54482470
106pentose-phosphate shunt (GO:0006098)2.53947586
107phospholipid efflux (GO:0033700)2.53802479
108response to peptidoglycan (GO:0032494)2.53275515
109protoporphyrinogen IX metabolic process (GO:0046501)2.53101364
110cellular ketone body metabolic process (GO:0046950)2.52906972
111cullin deneddylation (GO:0010388)2.52780095
112DNA deamination (GO:0045006)2.52632449
113COPII vesicle coating (GO:0048208)2.52146636
114regulation of cellular amino acid metabolic process (GO:0006521)2.52001925
115low-density lipoprotein particle remodeling (GO:0034374)2.51813819
116L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51627550
117signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.51550329
118signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.51550329
119signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.51550329
120antigen processing and presentation of endogenous antigen (GO:0019883)2.51087937
121proline metabolic process (GO:0006560)2.51015339
122tricarboxylic acid cycle (GO:0006099)2.50026546
123regulation of metalloenzyme activity (GO:0048552)2.49711086
124flavonoid metabolic process (GO:0009812)2.49666858
125heme biosynthetic process (GO:0006783)2.48336169
126signal transduction involved in DNA damage checkpoint (GO:0072422)2.47638171
127signal transduction involved in DNA integrity checkpoint (GO:0072401)2.47638171
128negative regulation of interleukin-12 production (GO:0032695)2.46392018
129regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.42040056
130rRNA methylation (GO:0031167)2.41619500
131signal transduction involved in cell cycle checkpoint (GO:0072395)2.41341629
132NIK/NF-kappaB signaling (GO:0038061)2.40985680
133nucleobase-containing small molecule interconversion (GO:0015949)2.38856411
134ribosomal small subunit biogenesis (GO:0042274)2.37512334
135respiratory electron transport chain (GO:0022904)2.37310687
136protein targeting to mitochondrion (GO:0006626)2.34930448
137anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.34048665
138immunoglobulin mediated immune response (GO:0016064)2.33004800
139electron transport chain (GO:0022900)2.31367341
140ribosome biogenesis (GO:0042254)2.28950465
141establishment of protein localization to mitochondrial membrane (GO:0090151)2.26333532
142fructose metabolic process (GO:0006000)2.25903930
143chaperone-mediated protein transport (GO:0072321)2.25824110
144positive regulation of gamma-delta T cell activation (GO:0046645)2.24849389
145ceramide catabolic process (GO:0046514)2.24774111
146negative regulation of cell killing (GO:0031342)2.22756958
147negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.22756958
148ribosome assembly (GO:0042255)2.22498191
149purine nucleotide salvage (GO:0032261)2.21691538
150formation of translation preinitiation complex (GO:0001731)2.21407787
151regulation of T cell tolerance induction (GO:0002664)2.20190442
152NADPH regeneration (GO:0006740)2.19020414
153regulation of interferon-beta biosynthetic process (GO:0045357)2.18902036
154nucleotide-sugar biosynthetic process (GO:0009226)2.17779306
155regulation of chronic inflammatory response (GO:0002676)2.17490519
156positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.15683948
157positive regulation of ligase activity (GO:0051351)2.15059409
158purine deoxyribonucleotide catabolic process (GO:0009155)2.13855551
159positive regulation of T cell mediated cytotoxicity (GO:0001916)2.12443832
160positive regulation of cell cycle arrest (GO:0071158)2.10304365
161respiratory chain complex IV assembly (GO:0008535)2.09731534
162detection of bacterium (GO:0016045)2.09351455
163ribonucleoprotein complex biogenesis (GO:0022613)2.09002448
164establishment of protein localization to mitochondrion (GO:0072655)2.08688354
165detection of other organism (GO:0098543)2.08665143
166pinocytosis (GO:0006907)2.08460001
167transcription elongation from RNA polymerase III promoter (GO:0006385)2.07959633
168termination of RNA polymerase III transcription (GO:0006386)2.07959633
169modulation by symbiont of host defense response (GO:0052031)2.07897537
170modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.07897537
171modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.07897537
172positive regulation by organism of defense response of other organism involved in symbiotic interact2.07897537
173modulation by symbiont of host immune response (GO:0052553)2.07897537
174positive regulation by symbiont of host defense response (GO:0052509)2.07897537
175mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.07372473
176protein localization to mitochondrion (GO:0070585)2.06839963
177guanosine-containing compound biosynthetic process (GO:1901070)2.06831490
178regulation of cellular amine metabolic process (GO:0033238)2.06106998
179purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.05369073
180regulation of translation in response to stress (GO:0043555)2.04319448
181respiratory burst (GO:0045730)2.03849784
182nucleotide salvage (GO:0043173)2.02741828

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.85055956
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49063008
3CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.43139446
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31224538
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.21417745
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.10171424
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.05063119
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03927703
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.90468801
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.89670411
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.87089167
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80472166
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.79641700
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76400638
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.75989161
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.74826123
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.50551301
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.46632418
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.45649575
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.25533731
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19269706
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.16792888
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16503026
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10663845
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.03760748
26LXR_22158963_ChIP-Seq_LIVER_Mouse1.96069622
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.93253822
28DCP1A_22483619_ChIP-Seq_HELA_Human1.90730462
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89367364
30VDR_23849224_ChIP-Seq_CD4+_Human1.87561478
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86743061
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85353447
33* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82571132
34VDR_21846776_ChIP-Seq_THP-1_Human1.76179456
35FOXP3_21729870_ChIP-Seq_TREG_Human1.73243310
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71875050
37GABP_19822575_ChIP-Seq_HepG2_Human1.71834574
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68818402
39ERG_20887958_ChIP-Seq_HPC-7_Mouse1.67695767
40* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66534183
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65143830
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63871707
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58279380
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55814370
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.55147124
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54820644
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53450823
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52632330
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51859700
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51497305
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49761939
52GATA1_22025678_ChIP-Seq_K562_Human1.48481662
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47462725
54XRN2_22483619_ChIP-Seq_HELA_Human1.46174410
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.44957824
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44765464
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44741447
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42719777
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37837419
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37063113
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33053839
62ZNF263_19887448_ChIP-Seq_K562_Human1.32814198
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32239874
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32202816
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31834998
66* SPI1_23547873_ChIP-Seq_NB4_Human1.31469072
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30794450
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29770476
69MYC_22102868_ChIP-Seq_BL_Human1.26664388
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.26047186
71ELK1_19687146_ChIP-ChIP_HELA_Human1.24319862
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23752198
73* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21115663
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20815811
75MAF_26560356_Chip-Seq_TH2_Human1.20789783
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20615377
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.19734782
78* TET1_21451524_ChIP-Seq_MESCs_Mouse1.19613498
79MAF_26560356_Chip-Seq_TH1_Human1.18121871
80* TFEB_21752829_ChIP-Seq_HELA_Human1.15722885
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15267829
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14266058
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.13958788
84RACK7_27058665_Chip-Seq_MCF-7_Human1.12720639
85LXR_22292898_ChIP-Seq_THP-1_Human1.12564442
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12102215
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11352923
88KDM5A_27292631_Chip-Seq_BREAST_Human1.09563848
89VDR_24763502_ChIP-Seq_THP-1_Human1.09271717
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08940325
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08921022
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08731492
93E2F7_22180533_ChIP-Seq_HELA_Human1.08118880
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07717052
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06561938
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05872930
97* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05680151
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05451091
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.04995607
100RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04347207
101ELF1_20517297_ChIP-Seq_JURKAT_Human1.03618953
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03419403
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03009302
104SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01778072
105RUNX1_22412390_ChIP-Seq_EML_Mouse1.00969329
106KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00945624
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99927379
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98637461
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96166989
110ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95862765
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95309338
112MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94451975
113MYC_18940864_ChIP-ChIP_HL60_Human0.94363479
114PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94317912
115TTF2_22483619_ChIP-Seq_HELA_Human0.93892026
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93819443
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93802030
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93137956
119CIITA_25753668_ChIP-Seq_RAJI_Human0.91165777
120PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90463783
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89646128
122NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89595583
123* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88700605
124CLOCK_20551151_ChIP-Seq_293T_Human0.88684086
125PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85459980
126* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84975334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.72963820
2MP0002139_abnormal_hepatobiliary_system4.75256823
3MP0003806_abnormal_nucleotide_metabolis4.27203335
4MP0005365_abnormal_bile_salt4.10831540
5MP0005085_abnormal_gallbladder_physiolo3.93431160
6MP0008875_abnormal_xenobiotic_pharmacok3.59255137
7MP0005451_abnormal_body_composition3.15035771
8MP0001666_abnormal_nutrient_absorption3.02180837
9MP0005083_abnormal_biliary_tract2.37739041
10MP0010329_abnormal_lipoprotein_level2.30518835
11MP0005332_abnormal_amino_acid2.28684473
12MP0003195_calcinosis2.25955811
13MP0003186_abnormal_redox_activity2.24277025
14MP0003252_abnormal_bile_duct2.10196292
15MP0009840_abnormal_foam_cell2.00524949
16MP0001764_abnormal_homeostasis1.96406559
17MP0005084_abnormal_gallbladder_morpholo1.83423637
18MP0009785_altered_susceptibility_to1.83337121
19MP0001790_abnormal_immune_system1.81528344
20MP0005387_immune_system_phenotype1.81528344
21MP0003724_increased_susceptibility_to1.79788053
22MP0003436_decreased_susceptibility_to1.78082954
23MP0008260_abnormal_autophagy1.76657959
24MP0006036_abnormal_mitochondrial_physio1.73187005
25MP0005636_abnormal_mineral_homeostasis1.73120654
26MP0005319_abnormal_enzyme/_coenzyme1.72495829
27MP0000013_abnormal_adipose_tissue1.71499259
28MP0009643_abnormal_urine_homeostasis1.71047170
29MP0000609_abnormal_liver_physiology1.68088206
30MP0005671_abnormal_response_to1.67885535
31MP0005220_abnormal_exocrine_pancreas1.64517910
32MP0003656_abnormal_erythrocyte_physiolo1.56474083
33MP0004043_abnormal_pH_regulation1.52503058
34MP0004147_increased_porphyrin_level1.52315946
35MP0003866_abnormal_defecation1.50269786
36MP0001835_abnormal_antigen_presentation1.44773216
37MP0002877_abnormal_melanocyte_morpholog1.39447583
38MP0001533_abnormal_skeleton_physiology1.39432843
39MP0008469_abnormal_protein_level1.38738934
40MP0000343_altered_response_to1.37019498
41MP0005584_abnormal_enzyme/coenzyme_acti1.36470699
42MP0003191_abnormal_cellular_cholesterol1.36091965
43MP0002118_abnormal_lipid_homeostasis1.34208732
44MP0000749_muscle_degeneration1.33715025
45MP0005025_abnormal_response_to1.33459963
46MP0003868_abnormal_feces_composition1.32882882
47MP0003303_peritoneal_inflammation1.32634069
48MP0004019_abnormal_vitamin_homeostasis1.29869251
49MP0003693_abnormal_embryo_hatching1.29565834
50MP0002132_abnormal_respiratory_system1.27165979
51MP0002693_abnormal_pancreas_physiology1.27013188
52MP0002138_abnormal_hepatobiliary_system1.26850288
53MP0001845_abnormal_inflammatory_respons1.26583715
54MP0003183_abnormal_peptide_metabolism1.24492846
55MP0009379_abnormal_foot_pigmentation1.20074094
56MP0009333_abnormal_splenocyte_physiolog1.19280144
57MP0005408_hypopigmentation1.19087079
58MP0004264_abnormal_extraembryonic_tissu1.18301267
59MP0003763_abnormal_thymus_physiology1.18183983
60MP0001661_extended_life_span1.17848723
61MP0006035_abnormal_mitochondrial_morpho1.17373814
62MP0008058_abnormal_DNA_repair1.17050704
63MP0002277_abnormal_respiratory_mucosa1.14312309
64MP0004510_myositis1.14253936
65MP0002405_respiratory_system_inflammati1.13979240
66MP0010155_abnormal_intestine_physiology1.13854014
67MP0005464_abnormal_platelet_physiology1.13364434
68MP0003111_abnormal_nucleus_morphology1.12407421
69MP0005330_cardiomyopathy1.10769014
70MP0005058_abnormal_lysosome_morphology1.10078817
71MP0005000_abnormal_immune_tolerance1.09308759
72MP0009764_decreased_sensitivity_to1.08798376
73MP0002419_abnormal_innate_immunity1.08395514
74MP0004947_skin_inflammation1.07818336
75MP0000015_abnormal_ear_pigmentation1.07745851
76MP0001881_abnormal_mammary_gland1.07736574
77MP0010386_abnormal_urinary_bladder1.06858013
78MP0001800_abnormal_humoral_immune1.06588237
79MP0005310_abnormal_salivary_gland1.04197537
80MP0002078_abnormal_glucose_homeostasis1.02185795
81MP0001756_abnormal_urination1.02135495
82MP0000750_abnormal_muscle_regeneration1.02040809
83MP0002148_abnormal_hypersensitivity_rea1.01486848
84MP0002837_dystrophic_cardiac_calcinosis1.00905096
85MP0000490_abnormal_crypts_of1.00827436
86MP0004381_abnormal_hair_follicle1.00445366
87MP0000747_muscle_weakness1.00428496
88MP0010352_gastrointestinal_tract_polyps1.00343497
89MP0009765_abnormal_xenobiotic_induced0.99775314
90MP0002723_abnormal_immune_serum0.99248233
91MP0003075_altered_response_to0.98541457
92MP0006054_spinal_hemorrhage0.98516618
93MP0000598_abnormal_liver_morphology0.98352779
94MP0000685_abnormal_immune_system0.98331265
95MP0009697_abnormal_copulation0.98293036
96MP0003786_premature_aging0.98291317
97MP0000604_amyloidosis0.97778003
98MP0005670_abnormal_white_adipose0.96505293
99MP0006082_CNS_inflammation0.95842006
100MP0003172_abnormal_lysosome_physiology0.95360747
101MP0002420_abnormal_adaptive_immunity0.95200978
102MP0001944_abnormal_pancreas_morphology0.93837443
103MP0001819_abnormal_immune_cell0.93505990
104MP0009763_increased_sensitivity_to0.93412177
105MP0010234_abnormal_vibrissa_follicle0.93160081
106MP0005165_increased_susceptibility_to0.92564711
107MP0009642_abnormal_blood_homeostasis0.92117701
108MP0002396_abnormal_hematopoietic_system0.91669452
109MP0001873_stomach_inflammation0.90669723
110MP0005166_decreased_susceptibility_to0.90276220
111MP0002876_abnormal_thyroid_physiology0.88628851
112MP0000858_altered_metastatic_potential0.88158831
113MP0005075_abnormal_melanosome_morpholog0.86970302
114MP0002452_abnormal_antigen_presenting0.86161964
115MP0008873_increased_physiological_sensi0.85765892
116MP0005376_homeostasis/metabolism_phenot0.85152042
117MP0003718_maternal_effect0.83842376
118MP0001853_heart_inflammation0.82724586
119MP0004782_abnormal_surfactant_physiolog0.81732158
120MP0002398_abnormal_bone_marrow0.80614797
121MP0000716_abnormal_immune_system0.80351676
122MP0002796_impaired_skin_barrier0.79878804
123MP0005266_abnormal_metabolism0.79474299
124MP0000689_abnormal_spleen_morphology0.78974149
125MP0002166_altered_tumor_susceptibility0.78543616
126MP0004957_abnormal_blastocyst_morpholog0.77152940
127MP0003646_muscle_fatigue0.77105521
128MP0002429_abnormal_blood_cell0.76217230
129MP0000313_abnormal_cell_death0.75748906
130MP0001663_abnormal_digestive_system0.74853763
131MP0000358_abnormal_cell_content/0.74830657
132MP0003879_abnormal_hair_cell0.74301907
133MP0002136_abnormal_kidney_physiology0.74187776
134MP0002006_tumorigenesis0.74133689
135MP0002722_abnormal_immune_system0.73980307
136MP0003448_altered_tumor_morphology0.73927402
137MP0005535_abnormal_body_temperature0.72749612

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.57860820
2Generalized aminoaciduria (HP:0002909)3.96186771
3Hypobetalipoproteinemia (HP:0003563)3.81029583
4Prolonged partial thromboplastin time (HP:0003645)3.69643876
5Hepatic necrosis (HP:0002605)3.64468570
6Hepatocellular necrosis (HP:0001404)3.52969461
7Acute necrotizing encephalopathy (HP:0006965)3.42913833
8Acute encephalopathy (HP:0006846)3.39641477
9Mitochondrial inheritance (HP:0001427)3.38497899
10Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37903959
11Intrahepatic cholestasis (HP:0001406)3.35679163
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.35291135
13Abnormal mitochondria in muscle tissue (HP:0008316)3.32950402
14Ketosis (HP:0001946)3.23142601
15Lipid accumulation in hepatocytes (HP:0006561)3.20093692
16Xanthomatosis (HP:0000991)3.15349902
17Nausea (HP:0002018)3.14621195
18Hypoglycemic coma (HP:0001325)3.11403278
19Abnormality of fatty-acid metabolism (HP:0004359)3.05364812
20Ketoacidosis (HP:0001993)3.04970891
21Cerebral edema (HP:0002181)3.04501142
22Increased CSF lactate (HP:0002490)3.02855457
23Abnormality of the intrinsic pathway (HP:0010989)2.87020176
24Increased hepatocellular lipid droplets (HP:0006565)2.86845098
25Fat malabsorption (HP:0002630)2.86654591
26Gout (HP:0001997)2.84915671
27Abnormality of macrophages (HP:0004311)2.84395545
28Recurrent abscess formation (HP:0002722)2.82003453
29Abnormality of liposaccharide metabolism (HP:0010968)2.81004952
30Abnormality of glycosphingolipid metabolism (HP:0004343)2.81004952
31Abnormality of glycolipid metabolism (HP:0010969)2.81004952
32Progressive macrocephaly (HP:0004481)2.79298768
33Vacuolated lymphocytes (HP:0001922)2.78433253
34Glycosuria (HP:0003076)2.73121885
35Abnormality of urine glucose concentration (HP:0011016)2.73121885
36Abnormality of the common coagulation pathway (HP:0010990)2.72255947
37Lethargy (HP:0001254)2.72249881
38Hyperammonemia (HP:0001987)2.71299469
39Conjugated hyperbilirubinemia (HP:0002908)2.70508662
40Increased muscle lipid content (HP:0009058)2.70150316
41Reduced antithrombin III activity (HP:0001976)2.69962851
42Myositis (HP:0100614)2.67767670
43Orchitis (HP:0100796)2.66536048
44Recurrent bacterial skin infections (HP:0005406)2.65316649
45Type I transferrin isoform profile (HP:0003642)2.65188486
46Ragged-red muscle fibers (HP:0003200)2.60848781
47Increased intramyocellular lipid droplets (HP:0012240)2.56357816
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56042699
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56042699
50Hyperbilirubinemia (HP:0002904)2.54723053
51Renal Fanconi syndrome (HP:0001994)2.53226315
52Deep venous thrombosis (HP:0002625)2.52446520
53CNS demyelination (HP:0007305)2.46522774
54Lactic acidosis (HP:0003128)2.46284901
55Metabolic acidosis (HP:0001942)2.46179734
56Symptomatic seizures (HP:0011145)2.45783411
57Testicular atrophy (HP:0000029)2.44927456
58Abnormality of placental membranes (HP:0011409)2.43302051
59Amniotic constriction ring (HP:0009775)2.43302051
60Abnormality of purine metabolism (HP:0004352)2.41386324
61Hyperlipoproteinemia (HP:0010980)2.39948434
62Rhabdomyolysis (HP:0003201)2.37775840
63Hepatosplenomegaly (HP:0001433)2.36653619
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.36341450
65Abnormality of glutamine family amino acid metabolism (HP:0010902)2.35327599
66Exertional dyspnea (HP:0002875)2.34237150
67Hyperphosphaturia (HP:0003109)2.34050825
68Systemic lupus erythematosus (HP:0002725)2.33792062
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31383102
70Abnormal protein N-linked glycosylation (HP:0012347)2.31383102
71Abnormal protein glycosylation (HP:0012346)2.31383102
72Abnormal glycosylation (HP:0012345)2.31383102
73Abnormality of nucleobase metabolism (HP:0010932)2.28365813
74Exercise intolerance (HP:0003546)2.27370532
75Petechiae (HP:0000967)2.26615129
76Steatorrhea (HP:0002570)2.26526784
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.26370766
78Dicarboxylic aciduria (HP:0003215)2.26370766
79Increased serum ferritin (HP:0003281)2.26278206
80Rough bone trabeculation (HP:0100670)2.26177694
81Vomiting (HP:0002013)2.25856416
82Abnormality of sulfur amino acid metabolism (HP:0004339)2.24981801
83Optic neuritis (HP:0100653)2.24593627
84Retrobulbar optic neuritis (HP:0100654)2.24593627
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24492830
86Hyperglycinuria (HP:0003108)2.23290271
87* Anorexia (HP:0002039)2.21971398
88Progressive external ophthalmoplegia (HP:0000590)2.21927921
89Late onset (HP:0003584)2.21174266
90Elevated erythrocyte sedimentation rate (HP:0003565)2.20586588
913-Methylglutaconic aciduria (HP:0003535)2.19191366
92Aplastic anemia (HP:0001915)2.19143283
93Hypoglycemic seizures (HP:0002173)2.17553897
94Brushfield spots (HP:0001088)2.15785994
95Increased serum lactate (HP:0002151)2.14445283
96Abnormality of cells of the erythroid lineage (HP:0012130)2.14327709
97Thrombocytosis (HP:0001894)2.13647501
98Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12721262
99Hyperinsulinemic hypoglycemia (HP:0000825)2.12535860
100Abnormal gallbladder physiology (HP:0012438)2.12205443
101Cholecystitis (HP:0001082)2.12205443
102Respiratory failure (HP:0002878)2.12082391
103Delayed CNS myelination (HP:0002188)2.11122473
104Joint hemorrhage (HP:0005261)2.10397162
105Abnormality of glycine metabolism (HP:0010895)2.09050790
106Abnormality of serine family amino acid metabolism (HP:0010894)2.09050790
107Abnormality of glycolysis (HP:0004366)2.08092642
108Increased serum pyruvate (HP:0003542)2.08092642
109Hypolipoproteinemia (HP:0010981)2.07408407
110Malnutrition (HP:0004395)2.07053400
111Pancreatitis (HP:0001733)2.06543954
112Recurrent gram-negative bacterial infections (HP:0005420)2.05864117
113Myopathic facies (HP:0002058)2.03911863
114Chronic obstructive pulmonary disease (HP:0006510)2.03176673
115Obstructive lung disease (HP:0006536)2.03176673
116Abnormality of pyrimidine metabolism (HP:0004353)2.02324791
117Myocardial infarction (HP:0001658)2.01808080
118Abnormal trabecular bone morphology (HP:0100671)2.01353204
119Epiphyseal stippling (HP:0010655)2.00256971
120Complement deficiency (HP:0004431)2.00020659
121Proximal tubulopathy (HP:0000114)1.98940371
122Irritability (HP:0000737)1.98904409
123Hyperglycinemia (HP:0002154)1.98774399
124Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.98638300
125Respiratory difficulties (HP:0002880)1.97322639
126Nemaline bodies (HP:0003798)1.96740778
127Axonal loss (HP:0003447)1.93514176
128Abnormal number of erythroid precursors (HP:0012131)1.93430808
129Emotional lability (HP:0000712)1.93268874
130Eczematoid dermatitis (HP:0000976)1.91331995
131Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.90865162
132Progressive muscle weakness (HP:0003323)1.88702089
133Abnormality of the pancreatic islet cells (HP:0006476)1.88498210
134Abnormality of endocrine pancreas physiology (HP:0012093)1.88498210
135Opisthotonus (HP:0002179)1.87451508
136Spastic diplegia (HP:0001264)1.85534559
137Oral leukoplakia (HP:0002745)1.85167869
138Abnormal pupillary function (HP:0007686)1.82125433
139Abnormality of iron homeostasis (HP:0011031)1.79793828
140Urticaria (HP:0001025)1.78845618
141Progressive neurologic deterioration (HP:0002344)1.78219899
142Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.78095697
143Recurrent skin infections (HP:0001581)1.77725323
144Abnormality of T cell physiology (HP:0011840)1.76995510
145Muscle fiber inclusion bodies (HP:0100299)1.75417832
146Trismus (HP:0000211)1.74629998
147Multiple enchondromatosis (HP:0005701)1.73478100
148Cholelithiasis (HP:0001081)1.72687582
149Abnormalities of placenta or umbilical cord (HP:0001194)1.72675818
150Encephalitis (HP:0002383)1.70748757
151Palpitations (HP:0001962)1.70170408
152Loss of speech (HP:0002371)1.68846180

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.02527420
2MST43.13999733
3ERN13.00279772
4NME22.97648173
5NME12.95298851
6MAPKAPK32.94252334
7CDK192.70859933
8MAP3K122.62590621
9FRK2.57073084
10VRK22.51966439
11STK162.43031796
12TESK22.37962358
13EIF2AK12.33859447
14GRK62.24004787
15KDR2.14986381
16EIF2AK32.10532562
17SRPK11.94687582
18PDK21.94017794
19ZAP701.85163824
20BUB11.81803438
21MAP4K11.71520705
22SIK31.68250845
23FLT31.64095908
24PIM21.62321469
25RIPK41.62233639
26TESK11.61912995
27TRIM281.54122035
28ACVR1B1.52470125
29TSSK61.50635724
30IRAK41.48607034
31DAPK11.47424314
32TYK21.45103980
33PASK1.42280829
34MST1R1.39538215
35MYLK1.36583356
36JAK31.36412537
37TAOK31.34445383
38TXK1.31605991
39EEF2K1.30770735
40IRAK31.30491648
41TLK11.29812784
42FGFR41.29739023
43SMG11.23584123
44TBK11.20200135
45MUSK1.17499171
46SIK11.17294455
47TAOK11.11602435
48TAOK21.11562595
49SYK1.06975680
50RPS6KB21.05444399
51MARK31.03764761
52LRRK21.00993627
53PRPF4B1.00745352
54MAP3K21.00344917
55MAP3K100.99718858
56BMPR1B0.96247646
57ARAF0.95641790
58EPHB10.93590347
59TGFBR10.90928343
60ABL20.90510911
61PTK60.90357325
62MAPK110.87196375
63BTK0.85854083
64CLK10.84208614
65TEC0.81350077
66ERBB40.81216489
67ILK0.79682405
68MAP3K140.78551575
69WEE10.78511976
70MAP3K80.77940482
71IKBKB0.77898350
72PLK40.76016695
73MAP2K20.75602139
74MAP3K10.75217520
75ITK0.74930758
76TRIB30.74074567
77FGR0.72814490
78LCK0.72370048
79PRKD20.72042157
80LYN0.71253898
81VRK10.69573218
82MAPK40.68354614
83CSK0.66539416
84KIT0.65908061
85PDPK10.65500455
86MAP3K30.64738074
87IKBKE0.63417895
88EPHA20.61331086
89CCNB10.60149400
90PIK3CG0.59161516
91SCYL20.58885040
92GRK70.57460539
93BLK0.56493522
94BMPR20.55431345
95CDK70.54809417
96PRKCI0.52896117
97CAMKK20.52766568
98MAP2K60.52566835
99PRKG20.52063965
100AKT30.51138992
101OBSCN0.50938837
102DAPK30.50765533
103BRAF0.49751325
104WNK30.49230352
105LIMK10.48788452
106PDK30.47301839
107PDK40.47301839
108MAP3K50.46979904
109PAK10.46596482
110PAK40.45468716
111TGFBR20.45413064
112INSRR0.44550157
113STK40.44429177
114AURKA0.44194903
115STK100.43566283
116ADRBK20.42857641
117PRKCD0.42316984
118TTN0.41828649
119MAPKAPK20.40591929
120JAK10.39488814
121PIM10.39148405
122KSR20.39064217
123PBK0.38616984
124MAP3K110.37617724
125CSNK2A20.37452135
126NEK10.36889122
127RAF10.36232293
128JAK20.35462813
129HCK0.35080396
130MAP2K30.34879806
131CSNK1G30.34684427
132MAP2K70.34425199
133CSNK2A10.34078819
134MAPK120.33926980
135IRAK20.33271540
136RPS6KB10.32990706
137MET0.32793642
138PHKG20.32646611
139PHKG10.32646611
140STK240.31749605
141MAPK150.30957215

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.86734530
2Protein export_Homo sapiens_hsa030602.85218323
3Sulfur metabolism_Homo sapiens_hsa009202.75971752
4Proteasome_Homo sapiens_hsa030502.53775709
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.44068527
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.23569856
7Oxidative phosphorylation_Homo sapiens_hsa001902.16196698
8Folate biosynthesis_Homo sapiens_hsa007902.05391539
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.05188485
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02147661
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.99855059
12Ribosome_Homo sapiens_hsa030101.88231104
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84540558
14Peroxisome_Homo sapiens_hsa041461.83341970
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.83124670
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78677001
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.77641122
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77442096
19Parkinsons disease_Homo sapiens_hsa050121.70828500
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68370919
21Fat digestion and absorption_Homo sapiens_hsa049751.67978547
22Caffeine metabolism_Homo sapiens_hsa002321.63704091
23Pyruvate metabolism_Homo sapiens_hsa006201.63157121
24Tryptophan metabolism_Homo sapiens_hsa003801.62006701
25Fatty acid degradation_Homo sapiens_hsa000711.59439323
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.57596073
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.56727876
28Selenocompound metabolism_Homo sapiens_hsa004501.50473973
29beta-Alanine metabolism_Homo sapiens_hsa004101.50380653
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47888225
31Histidine metabolism_Homo sapiens_hsa003401.47058785
32Arginine biosynthesis_Homo sapiens_hsa002201.46133150
33Butanoate metabolism_Homo sapiens_hsa006501.42792492
34Base excision repair_Homo sapiens_hsa034101.38824599
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35695190
36Carbon metabolism_Homo sapiens_hsa012001.35582149
37Propanoate metabolism_Homo sapiens_hsa006401.35069489
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.30606321
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29786502
40Fructose and mannose metabolism_Homo sapiens_hsa000511.29458705
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29191248
42Chemical carcinogenesis_Homo sapiens_hsa052041.27291834
43Alzheimers disease_Homo sapiens_hsa050101.26096878
44Phenylalanine metabolism_Homo sapiens_hsa003601.24750601
45* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24125250
46Biosynthesis of amino acids_Homo sapiens_hsa012301.23629597
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22988842
48Starch and sucrose metabolism_Homo sapiens_hsa005001.20618502
49Glutathione metabolism_Homo sapiens_hsa004801.19920961
50Galactose metabolism_Homo sapiens_hsa000521.17611715
51Pentose phosphate pathway_Homo sapiens_hsa000301.15051985
52Fatty acid elongation_Homo sapiens_hsa000621.14396015
53Sulfur relay system_Homo sapiens_hsa041221.11659450
54Complement and coagulation cascades_Homo sapiens_hsa046101.09844327
55Fatty acid metabolism_Homo sapiens_hsa012121.02181938
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00506522
57RNA polymerase_Homo sapiens_hsa030200.98642276
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95599830
59Pyrimidine metabolism_Homo sapiens_hsa002400.93370891
60Vitamin digestion and absorption_Homo sapiens_hsa049770.92500652
61Tyrosine metabolism_Homo sapiens_hsa003500.91534499
62Arginine and proline metabolism_Homo sapiens_hsa003300.90229154
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89828414
64Steroid biosynthesis_Homo sapiens_hsa001000.89621085
65Huntingtons disease_Homo sapiens_hsa050160.88105450
66Renin-angiotensin system_Homo sapiens_hsa046140.88083697
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.87400691
68Staphylococcus aureus infection_Homo sapiens_hsa051500.86320119
69Vibrio cholerae infection_Homo sapiens_hsa051100.84864601
70Allograft rejection_Homo sapiens_hsa053300.83518267
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.82841189
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.81807886
73Metabolic pathways_Homo sapiens_hsa011000.81672257
74Collecting duct acid secretion_Homo sapiens_hsa049660.81444445
75Herpes simplex infection_Homo sapiens_hsa051680.81393113
76One carbon pool by folate_Homo sapiens_hsa006700.80634710
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80384167
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.79613138
79Mineral absorption_Homo sapiens_hsa049780.79592283
80Osteoclast differentiation_Homo sapiens_hsa043800.79427739
81Leishmaniasis_Homo sapiens_hsa051400.79261879
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78935110
83Asthma_Homo sapiens_hsa053100.78505579
84PPAR signaling pathway_Homo sapiens_hsa033200.78408824
85Other glycan degradation_Homo sapiens_hsa005110.77129375
86N-Glycan biosynthesis_Homo sapiens_hsa005100.76292243
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75336379
88Rheumatoid arthritis_Homo sapiens_hsa053230.75090785
89Spliceosome_Homo sapiens_hsa030400.73428150
90Shigellosis_Homo sapiens_hsa051310.71066022
91Type I diabetes mellitus_Homo sapiens_hsa049400.70289911
92Pertussis_Homo sapiens_hsa051330.70108513
93Autoimmune thyroid disease_Homo sapiens_hsa053200.69620454
94Viral myocarditis_Homo sapiens_hsa054160.68833759
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68579245
96Tuberculosis_Homo sapiens_hsa051520.67713623
97Epstein-Barr virus infection_Homo sapiens_hsa051690.66784821
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66433111
99DNA replication_Homo sapiens_hsa030300.65731408
100Graft-versus-host disease_Homo sapiens_hsa053320.65374697
101Hematopoietic cell lineage_Homo sapiens_hsa046400.63006522
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62795108
103ABC transporters_Homo sapiens_hsa020100.62779158
104Legionellosis_Homo sapiens_hsa051340.62352470
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61743380
106Measles_Homo sapiens_hsa051620.61558525
107Retinol metabolism_Homo sapiens_hsa008300.61548856
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61450584
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59634953
110Salmonella infection_Homo sapiens_hsa051320.59593308
111Glycerolipid metabolism_Homo sapiens_hsa005610.58732473
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57198133
113Apoptosis_Homo sapiens_hsa042100.56263131
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52896635
115Mismatch repair_Homo sapiens_hsa034300.51475542
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51137096
117Bile secretion_Homo sapiens_hsa049760.47413203
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42648674
119Regulation of autophagy_Homo sapiens_hsa041400.41582712
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38384126
121Nucleotide excision repair_Homo sapiens_hsa034200.37885111
122Primary immunodeficiency_Homo sapiens_hsa053400.36923764
123Antigen processing and presentation_Homo sapiens_hsa046120.36121686
124Lysosome_Homo sapiens_hsa041420.36101366
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33719872
126Phagosome_Homo sapiens_hsa041450.33676942
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31422756
128Purine metabolism_Homo sapiens_hsa002300.26015040

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