MLXIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.59079437
2regulation of gamma-delta T cell differentiation (GO:0045586)5.36592452
3regulation of gamma-delta T cell activation (GO:0046643)5.16666775
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.68397327
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.68397327
6mannose metabolic process (GO:0006013)4.52968696
7antigen processing and presentation of endogenous antigen (GO:0019883)4.45648330
8positive thymic T cell selection (GO:0045059)4.08927071
9B cell receptor signaling pathway (GO:0050853)3.96820507
10regulation of interleukin-12 biosynthetic process (GO:0045075)3.80870069
11positive regulation of B cell differentiation (GO:0045579)3.78178331
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77692775
13positive regulation of histone deacetylation (GO:0031065)3.72880581
14positive regulation of fatty acid beta-oxidation (GO:0032000)3.62145629
15regulation of B cell differentiation (GO:0045577)3.51029515
16regulation of B cell receptor signaling pathway (GO:0050855)3.19917273
17negative regulation of cell killing (GO:0031342)3.18749355
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.18749355
19negative regulation of granulocyte differentiation (GO:0030853)3.18029933
20regulation of regulatory T cell differentiation (GO:0045589)3.12403993
21negative regulation of erythrocyte differentiation (GO:0045647)3.11099245
22T cell homeostasis (GO:0043029)3.09900198
23negative regulation of myotube differentiation (GO:0010832)3.09296899
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.09046905
25creatine metabolic process (GO:0006600)3.07984545
26regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.07615623
27regulation of skeletal muscle contraction (GO:0014819)3.06763061
28antigen processing and presentation via MHC class Ib (GO:0002475)3.03682167
29positive T cell selection (GO:0043368)3.01468842
30Peyers patch development (GO:0048541)2.99433387
31mucosal-associated lymphoid tissue development (GO:0048537)2.99433387
32histone H3-K4 trimethylation (GO:0080182)2.98183317
33negative regulation of cell size (GO:0045792)2.97119853
34JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.96527571
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.96420748
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.96420748
37positive regulation by organism of defense response of other organism involved in symbiotic interact2.96420748
38modulation by symbiont of host immune response (GO:0052553)2.96420748
39positive regulation by symbiont of host defense response (GO:0052509)2.96420748
40modulation by symbiont of host defense response (GO:0052031)2.96420748
41thymic T cell selection (GO:0045061)2.94939432
42positive regulation of fatty acid oxidation (GO:0046321)2.92536770
43leukocyte aggregation (GO:0070486)2.91130555
44regulation of fatty acid beta-oxidation (GO:0031998)2.90058810
45regulation of interferon-beta biosynthetic process (GO:0045357)2.89635783
46skeletal muscle contraction (GO:0003009)2.88994808
47cellular response to exogenous dsRNA (GO:0071360)2.87179317
48positive regulation of CREB transcription factor activity (GO:0032793)2.83210314
49T cell selection (GO:0045058)2.81736780
50lymphocyte homeostasis (GO:0002260)2.81692189
51negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.78535328
52positive regulation of protein deacetylation (GO:0090312)2.77671927
53negative regulation of phagocytosis (GO:0050765)2.72385129
54NIK/NF-kappaB signaling (GO:0038061)2.71736391
55myeloid dendritic cell activation (GO:0001773)2.68552597
56regulation of granulocyte differentiation (GO:0030852)2.68546854
57regulation of type I interferon-mediated signaling pathway (GO:0060338)2.64577658
58negative thymic T cell selection (GO:0045060)2.64452184
59antigen receptor-mediated signaling pathway (GO:0050851)2.62836579
60response to interleukin-15 (GO:0070672)2.61853984
61response to type I interferon (GO:0034340)2.61829022
62B cell homeostasis (GO:0001782)2.61585444
63cellular response to zinc ion (GO:0071294)2.60726397
64regulation of T cell tolerance induction (GO:0002664)2.60064981
65tolerance induction (GO:0002507)2.58419648
66histone H3-K4 methylation (GO:0051568)2.57458708
67myeloid dendritic cell differentiation (GO:0043011)2.57196405
68regulation of necroptotic process (GO:0060544)2.56899430
69negative T cell selection (GO:0043383)2.56388708
70natural killer cell differentiation (GO:0001779)2.56079355
71oxygen transport (GO:0015671)2.54767029
72positive regulation of granulocyte differentiation (GO:0030854)2.54476069
73positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.53729105
74muscle atrophy (GO:0014889)2.53673070
75negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.52451923
76macrophage activation involved in immune response (GO:0002281)2.51605416
77type I interferon signaling pathway (GO:0060337)2.51603009
78cellular response to type I interferon (GO:0071357)2.51603009
79Arp2/3 complex-mediated actin nucleation (GO:0034314)2.51102331
80defense response to protozoan (GO:0042832)2.49336872
81negative regulation of bone resorption (GO:0045779)2.49089976
82positive regulation of myotube differentiation (GO:0010831)2.48997883
83interferon-gamma-mediated signaling pathway (GO:0060333)2.48924522
84regulation of chromatin binding (GO:0035561)2.48711298
85response to protozoan (GO:0001562)2.47119524
86T cell migration (GO:0072678)2.46502660
87positive regulation of Rap GTPase activity (GO:0032854)2.46114969
88histone H3-K36 demethylation (GO:0070544)2.45743347
89B cell proliferation (GO:0042100)2.45739968
90peptidyl-lysine trimethylation (GO:0018023)2.45517814
91immunoglobulin mediated immune response (GO:0016064)2.45424580
92negative regulation of interleukin-8 production (GO:0032717)2.43587274
93germ cell migration (GO:0008354)2.42516303
94positive regulation of gene expression, epigenetic (GO:0045815)2.41946830
95skeletal muscle adaptation (GO:0043501)2.40802450
96leukocyte cell-cell adhesion (GO:0007159)2.40677566
97muscle filament sliding (GO:0030049)2.40043206
98actin-myosin filament sliding (GO:0033275)2.40043206
99hepatocyte apoptotic process (GO:0097284)2.39340250
100regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.39150460
101negative regulation of histone methylation (GO:0031061)2.38339678
102negative regulation of fatty acid transport (GO:2000192)2.38193473
103regulation of ARF GTPase activity (GO:0032312)2.37909960
104leukocyte homeostasis (GO:0001776)2.37164422
105regulation of integrin activation (GO:0033623)2.36321731
106negative regulation of translation, ncRNA-mediated (GO:0040033)2.35885564
107regulation of translation, ncRNA-mediated (GO:0045974)2.35885564
108negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.35885564
109gas transport (GO:0015669)2.34930996
110neutrophil activation (GO:0042119)2.34454710
111negative regulation of stress fiber assembly (GO:0051497)2.34236421
112regulation of fatty acid oxidation (GO:0046320)2.34119050
113cytoplasmic mRNA processing body assembly (GO:0033962)2.34022140
114germinal center formation (GO:0002467)2.33067647
115regulation of erythrocyte differentiation (GO:0045646)2.32873836
116definitive hemopoiesis (GO:0060216)2.32573686
117regulation of RNA export from nucleus (GO:0046831)2.31212502
118angiogenesis involved in wound healing (GO:0060055)2.31200275
119regulation of histone deacetylation (GO:0031063)2.31156947
120regulation of alpha-beta T cell proliferation (GO:0046640)2.31105741
121regulation of histone H3-K27 methylation (GO:0061085)2.29523683
122positive regulation of isotype switching (GO:0045830)2.29426781
123cellular extravasation (GO:0045123)2.28041231
124response to muramyl dipeptide (GO:0032495)2.27543439
125regulation of leukocyte degranulation (GO:0043300)2.27436081
126megakaryocyte development (GO:0035855)2.27365889
127positive regulation of lamellipodium assembly (GO:0010592)2.27304664
128striated muscle atrophy (GO:0014891)2.26760546
129positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.25841452
130embryonic hemopoiesis (GO:0035162)2.25603937
131lymph node development (GO:0048535)2.25554322
132regulation of myeloid leukocyte mediated immunity (GO:0002886)2.25501609
133carnitine transmembrane transport (GO:1902603)2.24562514
134interkinetic nuclear migration (GO:0022027)2.24262970
135intracellular estrogen receptor signaling pathway (GO:0030520)2.23327069
136detection of bacterium (GO:0016045)2.22550099
137regulation of hydrogen peroxide metabolic process (GO:0010310)2.22278208
138regulation of necrotic cell death (GO:0010939)2.21849286
139cellular response to virus (GO:0098586)2.20136621
140positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.19605064
1413-UTR-mediated mRNA stabilization (GO:0070935)2.19395973
142growth hormone receptor signaling pathway (GO:0060396)2.16867500
143positive regulation of protein kinase C signaling (GO:0090037)2.15310410
144phospholipid scrambling (GO:0017121)2.14338498
145response to peptidoglycan (GO:0032494)2.13411137
146myofibril assembly (GO:0030239)2.13216991
147endothelial cell chemotaxis (GO:0035767)2.12275752
148carnitine shuttle (GO:0006853)2.12240047
149histone H4 deacetylation (GO:0070933)2.09027980
150regulation of mast cell degranulation (GO:0043304)2.07469495
151modulation by virus of host process (GO:0019054)2.07069801
152glomerular filtration (GO:0003094)2.07035104
153osteoblast development (GO:0002076)2.06528391
154insulin-like growth factor receptor signaling pathway (GO:0048009)2.06365937
155detection of other organism (GO:0098543)2.05572085
156positive regulation of blood vessel endothelial cell migration (GO:0043536)2.04842206
157regulation of dendritic cell antigen processing and presentation (GO:0002604)2.04437372
158atrioventricular valve morphogenesis (GO:0003181)2.01933951
159histone lysine demethylation (GO:0070076)2.01809357
160renal filtration (GO:0097205)2.01469485
161negative regulation of viral release from host cell (GO:1902187)2.01118849
162activation of JUN kinase activity (GO:0007257)2.01113535

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.23171645
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.20336339
3MYC_22102868_ChIP-Seq_BL_Human4.17495373
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.17491794
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.63536317
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.26057755
7VDR_21846776_ChIP-Seq_THP-1_Human3.25659065
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.01460968
9TCF7_22412390_ChIP-Seq_EML_Mouse2.81530396
10SCL_19346495_ChIP-Seq_HPC-7_Human2.81050633
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.66681889
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.64353271
13MAF_26560356_Chip-Seq_TH1_Human2.55194886
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.53686014
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.49849095
16E2F7_22180533_ChIP-Seq_HELA_Human2.49561693
17* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40984842
18MYB_26560356_Chip-Seq_TH2_Human2.38922936
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.38814118
20RUNX_20019798_ChIP-Seq_JUKART_Human2.38760928
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.36318346
22VDR_24763502_ChIP-Seq_THP-1_Human2.30852983
23* UTX_26944678_Chip-Seq_JUKART_Human2.30097482
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28827938
25* IRF8_27001747_Chip-Seq_BMDM_Mouse2.28173887
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27499054
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.24645240
28KDM2B_26808549_Chip-Seq_DND41_Human2.22967171
29* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.19319885
30MYB_26560356_Chip-Seq_TH1_Human2.18505916
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.15492466
32CIITA_25753668_ChIP-Seq_RAJI_Human2.12491284
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.08021614
34MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03615880
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00361440
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98494946
37SPI1_23127762_ChIP-Seq_K562_Human1.98398069
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.94734578
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92560614
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.92086043
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90691417
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87574600
43* RUNX1_22412390_ChIP-Seq_EML_Mouse1.87086583
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85262565
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83545888
46* ELK3_25401928_ChIP-Seq_HUVEC_Human1.80589639
47* SPI1_23547873_ChIP-Seq_NB4_Human1.78628719
48* P68_20966046_ChIP-Seq_HELA_Human1.77538499
49DROSHA_22980978_ChIP-Seq_HELA_Human1.76393003
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.74996482
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68685317
52* KDM2B_26808549_Chip-Seq_K562_Human1.65448392
53MAF_26560356_Chip-Seq_TH2_Human1.64319458
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60834473
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.58021158
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.57216797
57* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52225370
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51701940
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50492414
60CREB1_26743006_Chip-Seq_LNCaP_Human1.48037719
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46611528
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.46276857
63GATA1_22025678_ChIP-Seq_K562_Human1.46034848
64SMC4_20622854_ChIP-Seq_HELA_Human1.45972094
65* GATA3_27048872_Chip-Seq_THYMUS_Human1.44927918
66BCOR_27268052_Chip-Seq_Bcells_Human1.44717750
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.43326748
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.41353237
69CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40521906
70* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40366706
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40345325
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40315754
73BCL6_27268052_Chip-Seq_Bcells_Human1.38290171
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37855279
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37606447
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37397919
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34656544
78* ELF1_20517297_ChIP-Seq_JURKAT_Human1.34589409
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33197872
80PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32933759
81FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.32567593
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.30927414
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30645626
84* KDM2B_26808549_Chip-Seq_JURKAT_Human1.28583427
85* NCOR1_26117541_ChIP-Seq_K562_Human1.27725751
86CTCF_27219007_Chip-Seq_Bcells_Human1.26263536
87* TP63_22573176_ChIP-Seq_HFKS_Human1.26236261
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24896864
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24675473
90* TET1_21451524_ChIP-Seq_MESCs_Mouse1.21621550
91PU_27001747_Chip-Seq_BMDM_Mouse1.20498067
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.19509325
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19035607
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.17644837
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16203763
96* E2F1_20622854_ChIP-Seq_HELA_Human1.16004644
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15683116
98CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15384892
99* PHF8_20622854_ChIP-Seq_HELA_Human1.14130949
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14065828
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10578317
102RXR_22158963_ChIP-Seq_LIVER_Mouse1.09264516
103SA1_27219007_Chip-Seq_Bcells_Human1.08329359
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08106496
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08082860
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08069058
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08055714
108LXR_22292898_ChIP-Seq_THP-1_Human1.07632838
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07095190
110OCT4_19829295_ChIP-Seq_ESCs_Human1.07039413
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05729371
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05710267
113* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04589920
114* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04082176
115ERG_21242973_ChIP-ChIP_JURKAT_Human1.02359932
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02224741
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01607503
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01586798
119ESR1_20079471_ChIP-ChIP_T-47D_Human1.00609583
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98330105
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97965067
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96722997
123* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94823510
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93325494
125TP63_17297297_ChIP-ChIP_HaCaT_Human0.91927636
126* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91880162
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90208833
128ESR1_21235772_ChIP-Seq_MCF-7_Human0.89587622
129VDR_24787735_ChIP-Seq_THP-1_Human0.89194529
130GATA1_19941826_ChIP-Seq_K562_Human0.88482750
131RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88181136
132* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87732430
133* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87077808
134GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86560233
135* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84390945
136ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83986465
137LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83624856
138GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83232589
139ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82554968
140RACK7_27058665_Chip-Seq_MCF-7_Human0.81994309
141TBX20_22080862_ChIP-Seq_HEART_Mouse0.81908699
142TBX20_22328084_ChIP-Seq_HEART_Mouse0.81908699
143GATA2_19941826_ChIP-Seq_K562_Human0.81287816
144RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81232457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.14300274
2MP0001835_abnormal_antigen_presentation3.05397166
3MP0009278_abnormal_bone_marrow2.82184213
4MP0000685_abnormal_immune_system2.70645824
5MP0001800_abnormal_humoral_immune2.69886771
6MP0001790_abnormal_immune_system2.65918870
7MP0005387_immune_system_phenotype2.65918870
8MP0004145_abnormal_muscle_electrophysio2.59862143
9MP0003300_gastrointestinal_ulcer2.59011665
10MP0002396_abnormal_hematopoietic_system2.57643157
11MP0004808_abnormal_hematopoietic_stem2.52629770
12MP0005409_darkened_coat_color2.43188867
13MP0003763_abnormal_thymus_physiology2.43018302
14MP0005671_abnormal_response_to2.40362225
15MP0002452_abnormal_antigen_presenting2.32331583
16MP0003303_peritoneal_inflammation2.31399525
17MP0002398_abnormal_bone_marrow2.16319446
18MP0003436_decreased_susceptibility_to2.13581266
19MP0000678_abnormal_parathyroid_gland2.12155007
20MP0002420_abnormal_adaptive_immunity2.12105117
21MP0005000_abnormal_immune_tolerance2.11023215
22MP0001819_abnormal_immune_cell2.10195503
23MP0001873_stomach_inflammation2.09804742
24MP0002723_abnormal_immune_serum2.08078758
25MP0002166_altered_tumor_susceptibility1.99743561
26MP0008961_abnormal_basal_metabolism1.89679358
27MP0000716_abnormal_immune_system1.83927786
28MP0010352_gastrointestinal_tract_polyps1.83563211
29MP0004036_abnormal_muscle_relaxation1.83021505
30MP0004510_myositis1.81658371
31MP0005076_abnormal_cell_differentiation1.81249200
32MP0001545_abnormal_hematopoietic_system1.78818523
33MP0005397_hematopoietic_system_phenotyp1.78818523
34MP0010155_abnormal_intestine_physiology1.76546119
35MP0000703_abnormal_thymus_morphology1.73826732
36MP0004947_skin_inflammation1.72061726
37MP0005025_abnormal_response_to1.71121483
38MP0005083_abnormal_biliary_tract1.70230595
39MP0000689_abnormal_spleen_morphology1.69832272
40MP0003866_abnormal_defecation1.68833311
41MP0003705_abnormal_hypodermis_morpholog1.68737256
42MP0009785_altered_susceptibility_to1.67043086
43MP0002722_abnormal_immune_system1.66963504
44MP0002405_respiratory_system_inflammati1.66184387
45MP0002419_abnormal_innate_immunity1.64488277
46MP0005058_abnormal_lysosome_morphology1.60569857
47MP0003183_abnormal_peptide_metabolism1.56574358
48MP0002429_abnormal_blood_cell1.54606617
49MP0000465_gastrointestinal_hemorrhage1.48877418
50MP0004858_abnormal_nervous_system1.47424019
51MP0002006_tumorigenesis1.47375245
52MP0002877_abnormal_melanocyte_morpholog1.46779632
53MP0003828_pulmonary_edema1.45835604
54MP0003566_abnormal_cell_adhesion1.41294008
55MP0001853_heart_inflammation1.39844642
56MP0009333_abnormal_splenocyte_physiolog1.39436086
57MP0002148_abnormal_hypersensitivity_rea1.38462854
58MP0000490_abnormal_crypts_of1.37252582
59MP0003656_abnormal_erythrocyte_physiolo1.36019999
60MP0002249_abnormal_larynx_morphology1.36018801
61MP0000759_abnormal_skeletal_muscle1.33329489
62MP0005310_abnormal_salivary_gland1.32362791
63MP0001765_abnormal_ion_homeostasis1.30203700
64MP0005464_abnormal_platelet_physiology1.29982890
65MP0000569_abnormal_digit_pigmentation1.28323276
66MP0000013_abnormal_adipose_tissue1.28237722
67MP0004043_abnormal_pH_regulation1.28085603
68MP0001845_abnormal_inflammatory_respons1.25457339
69MP0006138_congestive_heart_failure1.24061630
70MP0000733_abnormal_muscle_development1.21316844
71MP0000747_muscle_weakness1.20932433
72MP0001849_ear_inflammation1.20278014
73MP0005174_abnormal_tail_pigmentation1.19626392
74MP0002009_preneoplasia1.19458548
75MP0002933_joint_inflammation1.18921622
76MP0004084_abnormal_cardiac_muscle1.18849245
77MP0002138_abnormal_hepatobiliary_system1.18394631
78MP0003879_abnormal_hair_cell1.15738948
79MP0005369_muscle_phenotype1.12886490
80MP0000681_abnormal_thyroid_gland1.10787281
81MP0001664_abnormal_digestion1.09737990
82MP0004381_abnormal_hair_follicle1.09699117
83MP0010368_abnormal_lymphatic_system1.09554938
84MP0004130_abnormal_muscle_cell1.09210587
85MP0006054_spinal_hemorrhage1.04004818
86MP0003646_muscle_fatigue1.03835257
87MP0009840_abnormal_foam_cell1.03319612
88MP0000749_muscle_degeneration1.03303013
89MP0002132_abnormal_respiratory_system1.02887018
90MP0001533_abnormal_skeleton_physiology1.02577224
91MP0010630_abnormal_cardiac_muscle1.02009970
92MP0003045_fibrosis1.01860024
93MP0008004_abnormal_stomach_pH1.00072844
94MP0005381_digestive/alimentary_phenotyp0.99434854
95MP0004233_abnormal_muscle_weight0.98105857
96MP0000470_abnormal_stomach_morphology0.97968442
97MP0003279_aneurysm0.96128702
98MP0000767_abnormal_smooth_muscle0.94310012
99MP0008260_abnormal_autophagy0.92245441
100MP0010307_abnormal_tumor_latency0.91994852
101MP0005670_abnormal_white_adipose0.91151328
102MP0001879_abnormal_lymphatic_vessel0.91086356
103MP0000249_abnormal_blood_vessel0.90721892
104MP0003693_abnormal_embryo_hatching0.90700728
105MP0002332_abnormal_exercise_endurance0.89428794
106MP0005330_cardiomyopathy0.89404751
107MP0006082_CNS_inflammation0.89039013
108MP0004147_increased_porphyrin_level0.87716914
109MP0001851_eye_inflammation0.87262218
110MP0002019_abnormal_tumor_incidence0.86389882
111MP0002108_abnormal_muscle_morphology0.85963765
112MP0002928_abnormal_bile_duct0.85744251
113MP0004264_abnormal_extraembryonic_tissu0.85447217
114MP0003448_altered_tumor_morphology0.84166036
115MP0002106_abnormal_muscle_physiology0.83825691
116MP0003943_abnormal_hepatobiliary_system0.82154807
117MP0002971_abnormal_brown_adipose0.81718391
118MP0004087_abnormal_muscle_fiber0.81549846
119MP0002998_abnormal_bone_remodeling0.81529077
120MP0002925_abnormal_cardiovascular_devel0.80640686
121MP0003091_abnormal_cell_migration0.80421922
122MP0002693_abnormal_pancreas_physiology0.76718251
123MP0008007_abnormal_cellular_replicative0.76576203
124MP0000003_abnormal_adipose_tissue0.75923946
125MP0003077_abnormal_cell_cycle0.75818457
126MP0004185_abnormal_adipocyte_glucose0.74938979
127MP0003172_abnormal_lysosome_physiology0.73975198
128MP0005375_adipose_tissue_phenotype0.73063609
129MP0008995_early_reproductive_senescence0.71052412
130MP0000266_abnormal_heart_morphology0.70621580
131MP0000858_altered_metastatic_potential0.67925218
132MP0003984_embryonic_growth_retardation0.67729654
133MP0000750_abnormal_muscle_regeneration0.67257399
134MP0003795_abnormal_bone_structure0.66576864
135MP0005023_abnormal_wound_healing0.66295614
136MP0002088_abnormal_embryonic_growth/wei0.65650311
137MP0003724_increased_susceptibility_to0.64841906
138MP0005666_abnormal_adipose_tissue0.62219492
139MP0000751_myopathy0.61726272
140MP0001663_abnormal_digestive_system0.61666098
141MP0000313_abnormal_cell_death0.60794445

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.75173244
2Abnormality of the fingertips (HP:0001211)4.50163458
3Muscle fiber inclusion bodies (HP:0100299)4.14948943
4Agammaglobulinemia (HP:0004432)4.11401322
5Nemaline bodies (HP:0003798)3.97753944
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.95519789
7Type 1 muscle fiber predominance (HP:0003803)3.89552909
8Cellulitis (HP:0100658)3.87788737
9Obstructive sleep apnea (HP:0002870)3.82720035
10Myopathic facies (HP:0002058)3.78156236
11Recurrent viral infections (HP:0004429)3.51088702
12Centrally nucleated skeletal muscle fibers (HP:0003687)3.45688262
13Recurrent fungal infections (HP:0002841)3.33176055
14Recurrent bronchitis (HP:0002837)3.30758068
15Chronic otitis media (HP:0000389)3.26020793
16Panhypogammaglobulinemia (HP:0003139)3.24516269
17Inflammation of the large intestine (HP:0002037)3.16239147
18Gastrointestinal inflammation (HP:0004386)3.12627828
19Colitis (HP:0002583)3.09662232
20Hematochezia (HP:0002573)3.06218699
21Increased connective tissue (HP:0009025)3.04588535
22Spontaneous hematomas (HP:0007420)3.02025207
23Eczematoid dermatitis (HP:0000976)2.96732151
24Distal lower limb amyotrophy (HP:0008944)2.93612780
25Verrucae (HP:0200043)2.93302560
26Papilloma (HP:0012740)2.93302560
27Muscle fiber splitting (HP:0003555)2.89811609
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.87470126
29Abnormality of skeletal muscle fiber size (HP:0012084)2.87468015
30IgM deficiency (HP:0002850)2.86293749
31Broad face (HP:0000283)2.85051756
32Thyroiditis (HP:0100646)2.81487462
33Abnormality of B cell number (HP:0010975)2.80486569
34B lymphocytopenia (HP:0010976)2.80486569
35Recurrent abscess formation (HP:0002722)2.79280635
36Round ear (HP:0100830)2.76402264
37Meningitis (HP:0001287)2.75042750
38Asymmetric septal hypertrophy (HP:0001670)2.73727498
39Abnormality of the nasal mucosa (HP:0000433)2.66426321
40Increased variability in muscle fiber diameter (HP:0003557)2.64195767
41Easy fatigability (HP:0003388)2.61724081
42Hyperkalemia (HP:0002153)2.59340243
43Gastrointestinal stroma tumor (HP:0100723)2.58623773
44Hyperacusis (HP:0010780)2.58219837
45Myositis (HP:0100614)2.57248472
46Recurrent bacterial skin infections (HP:0005406)2.55127296
47Long eyelashes (HP:0000527)2.54947989
48Mildly elevated creatine phosphokinase (HP:0008180)2.54088484
49Flat acetabular roof (HP:0003180)2.54079155
50T lymphocytopenia (HP:0005403)2.50707878
51Distal lower limb muscle weakness (HP:0009053)2.50543154
52Cerebral aneurysm (HP:0004944)2.50488286
53Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.50308787
54Hemorrhage of the eye (HP:0011885)2.48395233
55Osteomyelitis (HP:0002754)2.47929547
56Nasal polyposis (HP:0100582)2.41804022
57Autoimmune thrombocytopenia (HP:0001973)2.40708208
58Polycythemia (HP:0001901)2.39844564
59Chronic mucocutaneous candidiasis (HP:0002728)2.39701855
60Recurrent cutaneous fungal infections (HP:0011370)2.39701855
61Lymphopenia (HP:0001888)2.38699984
62Abnormality of the intervertebral disk (HP:0005108)2.38114557
63Increased density of long bones (HP:0006392)2.37288967
64Chest pain (HP:0100749)2.37275124
65Thin bony cortex (HP:0002753)2.36252954
66Abnormality of T cell number (HP:0011839)2.34788913
67Elevated erythrocyte sedimentation rate (HP:0003565)2.34043172
68Pustule (HP:0200039)2.33220154
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.29515307
70Muscle hypertrophy of the lower extremities (HP:0008968)2.27088826
71Bulbar palsy (HP:0001283)2.26877208
72Abnormality of T cells (HP:0002843)2.26361908
73Mediastinal lymphadenopathy (HP:0100721)2.25198192
74Ileus (HP:0002595)2.24199595
75Hyporeflexia of lower limbs (HP:0002600)2.22037495
76Rectal prolapse (HP:0002035)2.21883049
77Aortic aneurysm (HP:0004942)2.20813779
78Chronic sinusitis (HP:0011109)2.18018081
79Emphysema (HP:0002097)2.17320493
80Vasculitis (HP:0002633)2.15723872
81Epistaxis (HP:0000421)2.15074102
82Decreased circulating renin level (HP:0003351)2.14989129
83Facial diplegia (HP:0001349)2.13862720
84Severe combined immunodeficiency (HP:0004430)2.10935534
85Sepsis (HP:0100806)2.09757758
86Dysmetric saccades (HP:0000641)2.09630480
87Vertebral arch anomaly (HP:0008438)2.09495598
88Macroorchidism (HP:0000053)2.08433291
89Stridor (HP:0010307)2.08376358
90Malnutrition (HP:0004395)2.08012117
91Hyperthyroidism (HP:0000836)2.07508380
92Periodontitis (HP:0000704)2.06053966
93Spinal cord lesions (HP:0100561)2.05590499
94Syringomyelia (HP:0003396)2.05590499
95Genetic anticipation (HP:0003743)2.04622498
96Clumsiness (HP:0002312)2.03715649
97Limited elbow extension (HP:0001377)2.02760596
98Lip pit (HP:0100267)2.02194501
99Difficulty running (HP:0009046)2.01635303
100Thrombocytosis (HP:0001894)1.99961569
101Atelectasis (HP:0100750)1.98213702
102Increased neuronal autofluorescent lipopigment (HP:0002074)1.97023787
103Abnormality of the heme biosynthetic pathway (HP:0010472)1.95578821
104Eosinophilia (HP:0001880)1.95491201
105Restrictive lung disease (HP:0002091)1.95023618
106Gingivitis (HP:0000230)1.94028939
107Ulnar deviation of the wrist (HP:0003049)1.93569807
108Petechiae (HP:0000967)1.93045251
109Abnormality of T cell physiology (HP:0011840)1.93020234
110Volvulus (HP:0002580)1.92148489
111Recurrent skin infections (HP:0001581)1.91342234
112Calf muscle hypertrophy (HP:0008981)1.91300107
113Chronic diarrhea (HP:0002028)1.90524112
114Prolonged bleeding time (HP:0003010)1.90261709
115Recurrent sinusitis (HP:0011108)1.89898525
116EMG: myopathic abnormalities (HP:0003458)1.88848057
117Arterial thrombosis (HP:0004420)1.87263185
118Acute myeloid leukemia (HP:0004808)1.86541384
119Abnormality of the left ventricular outflow tract (HP:0011103)1.85888013
120Subaortic stenosis (HP:0001682)1.85888013
121Muscle stiffness (HP:0003552)1.85476037
122Ventricular fibrillation (HP:0001663)1.85239551
123Orchitis (HP:0100796)1.85123348
124Urethral obstruction (HP:0000796)1.85036020
125Frequent falls (HP:0002359)1.84578016
126IgA deficiency (HP:0002720)1.84392388
127Spondylolisthesis (HP:0003302)1.83248514
128Reticulocytosis (HP:0001923)1.82757791
129Combined immunodeficiency (HP:0005387)1.82290714
130Neck muscle weakness (HP:0000467)1.82205249
131Interstitial pulmonary disease (HP:0006530)1.79920230
132Prominent nose (HP:0000448)1.79831004
133EMG: neuropathic changes (HP:0003445)1.79613978
134Abnormality of eosinophils (HP:0001879)1.79295231
135Leukocytosis (HP:0001974)1.78922002
136Bronchitis (HP:0012387)1.78807465
137Seborrheic dermatitis (HP:0001051)1.78240981
138Increased cerebral lipofuscin (HP:0011813)1.77753147
139Hemoptysis (HP:0002105)1.77439531
140Rhabdomyolysis (HP:0003201)1.77160498
141Increased serum ferritin (HP:0003281)1.76764169
142Persistence of primary teeth (HP:0006335)1.76229835
143Pulmonary infiltrates (HP:0002113)1.75574164
144Cheilitis (HP:0100825)1.72421623
145Abnormality of the columella (HP:0009929)1.72346108
146Optic neuritis (HP:0100653)1.70896656
147Retrobulbar optic neuritis (HP:0100654)1.70896656
148Increased IgE level (HP:0003212)1.70513976
149Hypoplasia of the thymus (HP:0000778)1.70263454
150Recurrent pneumonia (HP:0006532)1.69393746
151Skin ulcer (HP:0200042)1.69056257
152Onion bulb formation (HP:0003383)1.68642765
153Disproportionate tall stature (HP:0001519)1.68078907
154Distal arthrogryposis (HP:0005684)1.67925240
155Thoracic kyphosis (HP:0002942)1.67013209
156Aneurysm (HP:0002617)1.66975991
157Narrow palate (HP:0000189)1.66641052
158Fatigue (HP:0012378)1.66301789
159Difficulty climbing stairs (HP:0003551)1.66173408
160Segmental peripheral demyelination/remyelination (HP:0003481)1.65430891
161Hyperactive renin-angiotensin system (HP:0000841)1.65252009
162Lymphoma (HP:0002665)1.65142219
163Hypertensive crisis (HP:0100735)1.65084038
164Dislocated radial head (HP:0003083)1.64542052
165Generalized muscle weakness (HP:0003324)1.64538049
166IgG deficiency (HP:0004315)1.64253563
167Abnormality of iron homeostasis (HP:0011031)1.63424383
168Dysostosis multiplex (HP:0000943)1.63235140
169Germ cell neoplasia (HP:0100728)1.62969050
170Abnormality of the thoracic spine (HP:0100711)1.61828521
171Gastrointestinal dysmotility (HP:0002579)1.60960315
172Bowel incontinence (HP:0002607)1.59859824
173Abnormality of polysaccharide metabolism (HP:0011012)1.57514143
174Abnormality of glycosaminoglycan metabolism (HP:0004371)1.57514143
175Abnormality of mucopolysaccharide metabolism (HP:0011020)1.57514143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.03654113
2MAP3K103.85300616
3CDK123.27394420
4ERN12.94406150
5EEF2K2.86834195
6TRIB32.38189607
7FGFR42.24818706
8TGFBR22.22838312
9JAK32.15847815
10PRPF4B2.07008608
11TNK22.02427653
12TTN1.94858168
13FGFR31.90002576
14TYK21.87223677
15BTK1.78584770
16ZAP701.76150502
17SIK21.72449998
18TXK1.67690441
19STK101.66249418
20PKN21.65737214
21ITK1.61898567
22SIK31.60686804
23BRD41.60540157
24CAMK1D1.59056060
25KIT1.57877313
26JAK11.48766704
27CDC42BPA1.47355678
28CAMK1G1.45044279
29SYK1.42689706
30SIK11.41643184
31MAPK151.38190025
32IRAK41.35317336
33BLK1.35255967
34MST1R1.35111763
35SMG11.33858098
36TBK11.33468749
37CSF1R1.27597284
38HCK1.23107953
39IRAK31.20418439
40PTK61.19954376
41MAP3K141.18874211
42IKBKE1.15808500
43MAP3K11.15045534
44TEC1.14055048
45PHKG21.13392464
46PHKG11.13392464
47MAP2K31.12901316
48GRK61.12581806
49FLT31.11753563
50CHUK1.09305471
51FGFR21.08346287
52RIPK11.07732384
53MAP3K31.07293218
54MAP2K61.07039449
55TGFBR11.03697449
56DMPK1.03658996
57FES1.03536313
58LRRK21.00377325
59TIE11.00036901
60EPHB10.99258984
61PDPK10.99250317
62TAOK30.97365201
63EPHA20.96646245
64MAP3K70.95582065
65HIPK20.94566838
66IKBKB0.94348212
67PDGFRA0.91717910
68NLK0.88626546
69MAP2K20.88554971
70PRKAA20.88547184
71MAP3K110.87825870
72RPS6KL10.86946241
73RPS6KC10.86946241
74CDK90.86779277
75RPS6KA40.85944624
76MAP3K60.85867961
77ICK0.85808789
78BMX0.85782739
79LCK0.84396169
80MTOR0.81162884
81PDK10.78806732
82STK40.77885682
83NEK20.77564323
84PIM10.76110956
85MARK30.76023255
86PRKD30.75967307
87PDGFRB0.74863595
88LMTK20.74620590
89LYN0.73366484
90CDK40.72080726
91CSK0.71464382
92JAK20.69161101
93RIPK40.63185401
94CLK10.63019170
95CDK60.62309957
96PTK2B0.61096441
97STK30.58894259
98MAPKAPK30.57507848
99NME10.56145498
100WNK10.55379293
101MARK20.53065946
102MAP2K10.51970217
103KSR20.51648593
104EPHA30.51019889
105PRKG20.50643517
106PRKAA10.50364462
107STK380.49735607
108PIK3CA0.49673045
109MAP3K20.49630014
110PRKD20.48925193
111DYRK1B0.48567447
112IRAK10.47860151
113PASK0.47732656
114RPS6KB20.47711891
115MAPK110.46396339
116ATR0.45369128
117MUSK0.44793640
118RET0.44708305
119STK240.44380504
120MAPK120.43306090
121PRKD10.42689523
122SGK30.42553140
123PIK3CG0.42370808
124PRKCH0.42222031
125SCYL20.42111294
126MAPKAPK20.40907037
127ALK0.40504801
128MAP3K130.40069151
129TRPM70.37264127
130TAOK10.34596880
131MAPK70.33720824
132RPS6KA20.33483404
133ABL10.32105363
134RPS6KA60.30974347
135OBSCN0.30838392
136INSRR0.29864077

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.85205541
2B cell receptor signaling pathway_Homo sapiens_hsa046622.59588848
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.35379705
4Leishmaniasis_Homo sapiens_hsa051402.09196317
5Osteoclast differentiation_Homo sapiens_hsa043802.01021312
6Chronic myeloid leukemia_Homo sapiens_hsa052201.76384765
7Measles_Homo sapiens_hsa051621.72900105
8Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.61422811
9Toxoplasmosis_Homo sapiens_hsa051451.60660345
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59374686
11T cell receptor signaling pathway_Homo sapiens_hsa046601.58699150
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58011635
13Hematopoietic cell lineage_Homo sapiens_hsa046401.57801635
14Viral myocarditis_Homo sapiens_hsa054161.56798399
15Acute myeloid leukemia_Homo sapiens_hsa052211.56243481
16Herpes simplex infection_Homo sapiens_hsa051681.52913085
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.51619742
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48543917
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45504454
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41059980
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.40226899
22Notch signaling pathway_Homo sapiens_hsa043301.35480009
23Influenza A_Homo sapiens_hsa051641.35300127
24Antigen processing and presentation_Homo sapiens_hsa046121.31010737
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30639742
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29156080
27TNF signaling pathway_Homo sapiens_hsa046681.28781075
28Hepatitis B_Homo sapiens_hsa051611.28684082
29Pancreatic cancer_Homo sapiens_hsa052121.26807774
30Apoptosis_Homo sapiens_hsa042101.26543564
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.26178413
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.25018800
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24755744
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.22214461
35Shigellosis_Homo sapiens_hsa051311.18130543
36Small cell lung cancer_Homo sapiens_hsa052221.16510590
37GnRH signaling pathway_Homo sapiens_hsa049121.14840915
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14645716
39Lysine degradation_Homo sapiens_hsa003101.14582165
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.14519759
41Prolactin signaling pathway_Homo sapiens_hsa049171.14105394
42* Insulin resistance_Homo sapiens_hsa049311.12782137
43Dorso-ventral axis formation_Homo sapiens_hsa043201.12562048
44Tuberculosis_Homo sapiens_hsa051521.11721987
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11553256
46Non-small cell lung cancer_Homo sapiens_hsa052231.11058312
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.10711883
48Platelet activation_Homo sapiens_hsa046111.09014630
49HTLV-I infection_Homo sapiens_hsa051661.08262336
50Chemokine signaling pathway_Homo sapiens_hsa040621.07140128
51Legionellosis_Homo sapiens_hsa051341.05383493
52Pancreatic secretion_Homo sapiens_hsa049721.01739549
53Glycerophospholipid metabolism_Homo sapiens_hsa005641.01398411
54MicroRNAs in cancer_Homo sapiens_hsa052060.99987098
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99183370
56mTOR signaling pathway_Homo sapiens_hsa041500.98930265
57Colorectal cancer_Homo sapiens_hsa052100.96346708
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96005806
59Fructose and mannose metabolism_Homo sapiens_hsa000510.94579591
60Type II diabetes mellitus_Homo sapiens_hsa049300.93980790
61Pertussis_Homo sapiens_hsa051330.93922551
62Epstein-Barr virus infection_Homo sapiens_hsa051690.92152940
63Staphylococcus aureus infection_Homo sapiens_hsa051500.91836503
64FoxO signaling pathway_Homo sapiens_hsa040680.90812826
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89547014
66Viral carcinogenesis_Homo sapiens_hsa052030.89437769
67VEGF signaling pathway_Homo sapiens_hsa043700.88051882
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87316985
69Adherens junction_Homo sapiens_hsa045200.84839594
70Salmonella infection_Homo sapiens_hsa051320.81113700
71Glycerolipid metabolism_Homo sapiens_hsa005610.80985278
72Non-homologous end-joining_Homo sapiens_hsa034500.80590980
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79038798
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77353485
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.77284582
76Insulin signaling pathway_Homo sapiens_hsa049100.77202781
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76909518
78Hepatitis C_Homo sapiens_hsa051600.76834693
79Malaria_Homo sapiens_hsa051440.76408943
80Proteoglycans in cancer_Homo sapiens_hsa052050.76408298
81Allograft rejection_Homo sapiens_hsa053300.76386186
82ABC transporters_Homo sapiens_hsa020100.75976039
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74120165
84Bladder cancer_Homo sapiens_hsa052190.73817956
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72914624
86Endometrial cancer_Homo sapiens_hsa052130.71647323
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.70990496
88ErbB signaling pathway_Homo sapiens_hsa040120.70644247
89Focal adhesion_Homo sapiens_hsa045100.70215863
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70215779
91Other glycan degradation_Homo sapiens_hsa005110.69862116
92Glucagon signaling pathway_Homo sapiens_hsa049220.69331768
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69043538
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68868809
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67689483
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66836383
97Oxytocin signaling pathway_Homo sapiens_hsa049210.66587844
98Inositol phosphate metabolism_Homo sapiens_hsa005620.66441420
99Thyroid cancer_Homo sapiens_hsa052160.65764904
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65711633
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64402941
102Calcium signaling pathway_Homo sapiens_hsa040200.64104832
103Base excision repair_Homo sapiens_hsa034100.63708144
104Prostate cancer_Homo sapiens_hsa052150.63421375
105Estrogen signaling pathway_Homo sapiens_hsa049150.63240495
106Pathways in cancer_Homo sapiens_hsa052000.61161371
107HIF-1 signaling pathway_Homo sapiens_hsa040660.61047371
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60667614
109Linoleic acid metabolism_Homo sapiens_hsa005910.60234837
110p53 signaling pathway_Homo sapiens_hsa041150.59783199
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59375897
112Dilated cardiomyopathy_Homo sapiens_hsa054140.58907497
113Graft-versus-host disease_Homo sapiens_hsa053320.58567830
114N-Glycan biosynthesis_Homo sapiens_hsa005100.56124979
115Renal cell carcinoma_Homo sapiens_hsa052110.55595162
116mRNA surveillance pathway_Homo sapiens_hsa030150.54757420
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54726936
118Glioma_Homo sapiens_hsa052140.54722475
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54378171
120Gastric acid secretion_Homo sapiens_hsa049710.54291292
121Protein digestion and absorption_Homo sapiens_hsa049740.53872780
122MAPK signaling pathway_Homo sapiens_hsa040100.53848949
123Cholinergic synapse_Homo sapiens_hsa047250.53833673
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53702155
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53496430
126Asthma_Homo sapiens_hsa053100.53300879
127Circadian rhythm_Homo sapiens_hsa047100.52820169
128Amoebiasis_Homo sapiens_hsa051460.51363657
129Choline metabolism in cancer_Homo sapiens_hsa052310.49286414
130AMPK signaling pathway_Homo sapiens_hsa041520.49208816
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48842177
132Cell cycle_Homo sapiens_hsa041100.48488112
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46098311
134Autoimmune thyroid disease_Homo sapiens_hsa053200.45740282

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