MLXIPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.31811500
2L-phenylalanine catabolic process (GO:0006559)7.31811500
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.94073916
4L-phenylalanine metabolic process (GO:0006558)6.94073916
5aromatic amino acid family catabolic process (GO:0009074)6.36746551
6epoxygenase P450 pathway (GO:0019373)5.86897090
7exogenous drug catabolic process (GO:0042738)5.70661771
8indole-containing compound catabolic process (GO:0042436)5.65070114
9indolalkylamine catabolic process (GO:0046218)5.65070114
10tryptophan catabolic process (GO:0006569)5.65070114
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.45296037
12kynurenine metabolic process (GO:0070189)5.42531672
13tryptophan metabolic process (GO:0006568)5.41171818
14regulation of plasminogen activation (GO:0010755)5.38399367
15glyoxylate metabolic process (GO:0046487)5.27278113
16alpha-linolenic acid metabolic process (GO:0036109)5.26378286
17bile acid biosynthetic process (GO:0006699)5.19679791
18blood coagulation, intrinsic pathway (GO:0007597)5.11092840
19very-low-density lipoprotein particle assembly (GO:0034379)5.09516990
20omega-hydroxylase P450 pathway (GO:0097267)4.95335400
21peptidyl-glutamic acid carboxylation (GO:0017187)4.94845803
22protein carboxylation (GO:0018214)4.94845803
23urea metabolic process (GO:0019627)4.89597398
24urea cycle (GO:0000050)4.89597398
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88091995
26complement activation, alternative pathway (GO:0006957)4.86682894
27sulfur amino acid catabolic process (GO:0000098)4.82565249
28cysteine metabolic process (GO:0006534)4.77777042
29high-density lipoprotein particle remodeling (GO:0034375)4.70247572
30bile acid metabolic process (GO:0008206)4.68835664
31regulation of protein activation cascade (GO:2000257)4.65240129
32aromatic amino acid family metabolic process (GO:0009072)4.63412733
33negative regulation of fibrinolysis (GO:0051918)4.55303052
34regulation of fibrinolysis (GO:0051917)4.54311150
35ethanol metabolic process (GO:0006067)4.53284911
36nitrogen cycle metabolic process (GO:0071941)4.52262248
37tyrosine metabolic process (GO:0006570)4.50721966
38lysine metabolic process (GO:0006553)4.49633543
39lysine catabolic process (GO:0006554)4.49633543
40plasma lipoprotein particle organization (GO:0071827)4.46511454
41serine family amino acid catabolic process (GO:0009071)4.43855916
42homocysteine metabolic process (GO:0050667)4.42352219
43regulation of complement activation (GO:0030449)4.34473380
44regulation of triglyceride catabolic process (GO:0010896)4.32106431
45bile acid and bile salt transport (GO:0015721)4.29145182
46* triglyceride homeostasis (GO:0070328)4.29061486
47* acylglycerol homeostasis (GO:0055090)4.29061486
48acute-phase response (GO:0006953)4.24822912
49alpha-amino acid catabolic process (GO:1901606)4.20530681
50protein-lipid complex subunit organization (GO:0071825)4.20473771
51indolalkylamine metabolic process (GO:0006586)4.19187013
52amino-acid betaine metabolic process (GO:0006577)4.19094034
53reverse cholesterol transport (GO:0043691)4.19029492
54regulation of cholesterol esterification (GO:0010872)4.16363830
55low-density lipoprotein particle remodeling (GO:0034374)4.14016968
56phospholipid efflux (GO:0033700)4.13603928
57cellular ketone body metabolic process (GO:0046950)4.12056069
58protein-lipid complex assembly (GO:0065005)4.09707045
59coenzyme catabolic process (GO:0009109)4.04462301
60protein-lipid complex remodeling (GO:0034368)4.02907240
61macromolecular complex remodeling (GO:0034367)4.02907240
62plasma lipoprotein particle remodeling (GO:0034369)4.02907240
63regulation of cholesterol homeostasis (GO:2000188)4.00353862
64negative regulation of hemostasis (GO:1900047)4.00265173
65negative regulation of blood coagulation (GO:0030195)4.00265173
66negative regulation of cholesterol transport (GO:0032375)3.97657268
67negative regulation of sterol transport (GO:0032372)3.97657268
68imidazole-containing compound metabolic process (GO:0052803)3.97449996
69regulation of apoptotic cell clearance (GO:2000425)3.96841824
70cellular amino acid catabolic process (GO:0009063)3.91701461
71negative regulation of protein activation cascade (GO:2000258)3.89518018
72intestinal cholesterol absorption (GO:0030299)3.85954238
73amine catabolic process (GO:0009310)3.85843745
74cellular biogenic amine catabolic process (GO:0042402)3.85843745
75plasma lipoprotein particle clearance (GO:0034381)3.84546969
76regulation of bile acid biosynthetic process (GO:0070857)3.82546781
77intestinal absorption (GO:0050892)3.81566430
78cellular modified amino acid catabolic process (GO:0042219)3.81260396
79drug catabolic process (GO:0042737)3.80006586
80diacylglycerol metabolic process (GO:0046339)3.76925504
81benzene-containing compound metabolic process (GO:0042537)3.76767007
82glutamate metabolic process (GO:0006536)3.75463474
83drug transmembrane transport (GO:0006855)3.70548516
84fatty acid beta-oxidation (GO:0006635)3.70467349
85cholesterol efflux (GO:0033344)3.69846256
86phenylpropanoid metabolic process (GO:0009698)3.68756455
87negative regulation of coagulation (GO:0050819)3.68008244
88cellular glucuronidation (GO:0052695)3.67466337
89fatty acid oxidation (GO:0019395)3.65154668
90short-chain fatty acid metabolic process (GO:0046459)3.64786986
91regulation of humoral immune response (GO:0002920)3.62891451
92carboxylic acid catabolic process (GO:0046395)3.58002195
93organic acid catabolic process (GO:0016054)3.58002195
94lipid oxidation (GO:0034440)3.57739616
95positive regulation of hemostasis (GO:1900048)3.57600831
96positive regulation of blood coagulation (GO:0030194)3.57600831
97acetyl-CoA metabolic process (GO:0006084)3.55355474
98negative regulation of wound healing (GO:0061045)3.55354970
99glycine metabolic process (GO:0006544)3.54981410
100plasma lipoprotein particle assembly (GO:0034377)3.54299698
101ketone body metabolic process (GO:1902224)3.54192745
102ethanol oxidation (GO:0006069)3.53529894
103monocarboxylic acid catabolic process (GO:0072329)3.53098914
104urate metabolic process (GO:0046415)3.52981458
105fatty acid catabolic process (GO:0009062)3.52197949
106phospholipid homeostasis (GO:0055091)3.50585857
107oxidative demethylation (GO:0070989)3.48873055
108neutral lipid catabolic process (GO:0046461)3.48067694
109acylglycerol catabolic process (GO:0046464)3.48067694
110serine family amino acid metabolic process (GO:0009069)3.47484634
111cholesterol homeostasis (GO:0042632)3.45557490
1122-oxoglutarate metabolic process (GO:0006103)3.44695959
113negative regulation of lipase activity (GO:0060192)3.40780298
114sterol homeostasis (GO:0055092)3.40505285
115lipoprotein metabolic process (GO:0042157)3.37502384
116positive regulation of lipid catabolic process (GO:0050996)3.37496204
117complement activation, classical pathway (GO:0006958)3.37088873
118triglyceride catabolic process (GO:0019433)3.37063027
119positive regulation of lipoprotein lipase activity (GO:0051006)3.35882138
120positive regulation of triglyceride lipase activity (GO:0061365)3.35882138
121aldehyde catabolic process (GO:0046185)3.35245537
122valine metabolic process (GO:0006573)3.34892484
123complement activation (GO:0006956)3.34551438
124arginine metabolic process (GO:0006525)3.34390883
125fibrinolysis (GO:0042730)3.30772211
126glucuronate metabolic process (GO:0019585)3.28491627
127uronic acid metabolic process (GO:0006063)3.28491627
128protein activation cascade (GO:0072376)3.28234744
129drug metabolic process (GO:0017144)3.27276329
130sterol transport (GO:0015918)3.27114320
131cholesterol transport (GO:0030301)3.27114320
132positive regulation of coagulation (GO:0050820)3.26456715
133S-adenosylmethionine metabolic process (GO:0046500)3.25629479
134regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.25461665
135fat-soluble vitamin biosynthetic process (GO:0042362)3.25294264
136negative regulation of complement activation (GO:0045916)3.24720390
137proline metabolic process (GO:0006560)3.22948545
138regulation of triglyceride metabolic process (GO:0090207)3.20781460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.89683442
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.79941782
3* LXR_22158963_ChIP-Seq_LIVER_Mouse6.20568317
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.10150385
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.11930057
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.79018786
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.63975159
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05646014
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.57686032
10GATA1_22025678_ChIP-Seq_K562_Human2.24761109
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23793796
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.7095178
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95006639
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92483154
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.87542719
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73173259
17CLOCK_20551151_ChIP-Seq_293T_Human1.70814143
18* FOXA2_19822575_ChIP-Seq_HepG2_Human1.70675158
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46668616
20* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41695490
21SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39294661
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37501580
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33856911
24HTT_18923047_ChIP-ChIP_STHdh_Human1.31223249
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30623949
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23618863
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21674413
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17440808
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16436031
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15832177
31RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12655509
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11687369
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.10162984
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08191245
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99501880
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99122651
37* GATA4_25053715_ChIP-Seq_YYC3_Human0.96873632
38IRF8_22096565_ChIP-ChIP_GC-B_Human0.94699128
39DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94136674
40* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92973457
41MYC_19829295_ChIP-Seq_ESCs_Human0.90078412
42ZNF263_19887448_ChIP-Seq_K562_Human0.88121756
43ESR1_21235772_ChIP-Seq_MCF-7_Human0.87916200
44FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87848404
45CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86327698
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82403306
47SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82087374
48RARA_24833708_ChIP-Seq_LIVER_Mouse0.80644093
49ERA_21632823_ChIP-Seq_H3396_Human0.80568371
50RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79669934
51* TAF2_19829295_ChIP-Seq_ESCs_Human0.79655509
52* FOXH1_21741376_ChIP-Seq_ESCs_Human0.79509050
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.79468418
54ETV2_25802403_ChIP-Seq_MESCs_Mouse0.79322390
55ERG_21242973_ChIP-ChIP_JURKAT_Human0.79312138
56FOXA1_25552417_ChIP-Seq_VCAP_Human0.79226673
57LXR_22292898_ChIP-Seq_THP-1_Human0.78988639
58SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78742648
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78560347
60ESR2_21235772_ChIP-Seq_MCF-7_Human0.78404553
61SOX2_21211035_ChIP-Seq_LN229_Human0.78240167
62* BCAT_22108803_ChIP-Seq_LS180_Human0.77809569
63* DROSHA_22980978_ChIP-Seq_HELA_Human0.77598669
64TCF4_18268006_ChIP-ChIP_LS174T_Human0.77409509
65FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.76822924
66SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76347804
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76156016
68RARB_24833708_ChIP-Seq_LIVER_Mouse0.74944942
69NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.74852610
70REST_18959480_ChIP-ChIP_MESCs_Mouse0.74678347
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73632487
72* E2F1_20622854_ChIP-Seq_HELA_Human0.73373339
73SMC4_20622854_ChIP-Seq_HELA_Human0.72983674
74P68_20966046_ChIP-Seq_HELA_Human0.72421511
75BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70687747
76* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.70432240
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68918241
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68810342
79* CDX2_22108803_ChIP-Seq_LS180_Human0.68638000
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.67789422
81KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67377866
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.66549225
83SA1_27219007_Chip-Seq_Bcells_Human0.66332069
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66320393
85* AR_20517297_ChIP-Seq_VCAP_Human0.65303425
86SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64579452
87GATA6_25053715_ChIP-Seq_YYC3_Human0.63018336
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62964090
89STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.62570072
90BCOR_27268052_Chip-Seq_Bcells_Human0.62064574
91* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.61806536
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.60853275
93MYC_27129775_Chip-Seq_CORNEA_Mouse0.60665815
94RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60111362
95SOX2_22085726_ChIP-Seq_NPCs_Mouse0.59812753
96PHF8_20622854_ChIP-Seq_HELA_Human0.59199239
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.59127781
98ERG_20517297_ChIP-Seq_VCAP_Human0.58206080
99* GATA1_19941826_ChIP-Seq_K562_Human0.57038780
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.56339948
101FOXO3_23340844_ChIP-Seq_DLD1_Human0.55366553
102* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55147577
103TBX20_22328084_ChIP-Seq_HEART_Mouse0.54396259
104TBX20_22080862_ChIP-Seq_HEART_Mouse0.54396259
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.54021207
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.53929413
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.53899084
108NRF2_20460467_ChIP-Seq_MEFs_Mouse0.53899084
109* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.53777515
110ESET_19884257_ChIP-Seq_ESCs_Mouse0.53444778
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.53392041
112NFIB_24661679_ChIP-Seq_LUNG_Mouse0.53318527
113GATA1_19941827_ChIP-Seq_MEL_Mouse0.51657915
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.51500299
115P53_21459846_ChIP-Seq_SAOS-2_Human0.50600299
116SOX2_20726797_ChIP-Seq_SW620_Human0.49699894
117CBP_21632823_ChIP-Seq_H3396_Human0.49283831
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.49095683
119LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.48637887
120GATA3_24758297_ChIP-Seq_MCF-7_Human0.48041570
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47909097
122* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.47834582
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.47714938
124STAT1_17558387_ChIP-Seq_HELA_Human0.47656775
125OCT4_20526341_ChIP-Seq_ESCs_Human0.46439112
126* GATA2_19941826_ChIP-Seq_K562_Human0.46397421
127* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45841603
128CEBPB_22108803_ChIP-Seq_LS180_Human0.44979509
129* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.44740347
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.44375841
131CTCF_27219007_Chip-Seq_Bcells_Human0.43733704
132TET1_21451524_ChIP-Seq_MESCs_Mouse0.43591758
133FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.43562400
134RAC3_21632823_ChIP-Seq_H3396_Human0.43406158
135* MYC_19915707_ChIP-ChIP_AK7_Human0.43013933
136SPI1_26923725_Chip-Seq_HPCs_Mouse0.42834791
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41933585

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.68955553
2MP0005360_urolithiasis6.76115621
3MP0005085_abnormal_gallbladder_physiolo5.91907764
4MP0005365_abnormal_bile_salt5.84309932
5MP0008875_abnormal_xenobiotic_pharmacok4.52670607
6MP0003252_abnormal_bile_duct4.13498238
7MP0003195_calcinosis3.58140161
8MP0003806_abnormal_nucleotide_metabolis3.56559804
9MP0010329_abnormal_lipoprotein_level3.31418300
10MP0009840_abnormal_foam_cell2.94668807
11MP0005083_abnormal_biliary_tract2.76207478
12MP0001666_abnormal_nutrient_absorption2.66935097
13MP0005332_abnormal_amino_acid2.60427112
14* MP0002118_abnormal_lipid_homeostasis2.18733958
15MP0002138_abnormal_hepatobiliary_system2.14711142
16MP0003191_abnormal_cellular_cholesterol2.13440782
17MP0003122_maternal_imprinting2.13331256
18* MP0000609_abnormal_liver_physiology2.10144280
19MP0004019_abnormal_vitamin_homeostasis2.07248586
20MP0003868_abnormal_feces_composition1.95446119
21MP0005319_abnormal_enzyme/_coenzyme1.72869535
22MP0004043_abnormal_pH_regulation1.72388801
23MP0009643_abnormal_urine_homeostasis1.67385860
24MP0005220_abnormal_exocrine_pancreas1.61946048
25MP0001764_abnormal_homeostasis1.56578410
26MP0005670_abnormal_white_adipose1.56095113
27MP0003283_abnormal_digestive_organ1.51206196
28* MP0002078_abnormal_glucose_homeostasis1.47453684
29MP0003879_abnormal_hair_cell1.41959195
30MP0005584_abnormal_enzyme/coenzyme_acti1.38683075
31MP0002837_dystrophic_cardiac_calcinosis1.37242329
32MP0002693_abnormal_pancreas_physiology1.36127972
33MP0001944_abnormal_pancreas_morphology1.34045398
34MP0000566_synostosis1.28509969
35MP0002928_abnormal_bile_duct1.20923104
36MP0009780_abnormal_chondrocyte_physiolo1.18297046
37MP0003172_abnormal_lysosome_physiology1.13558646
38MP0005636_abnormal_mineral_homeostasis1.12951428
39MP0005451_abnormal_body_composition1.11269046
40MP0004264_abnormal_extraembryonic_tissu1.08646180
41* MP0000598_abnormal_liver_morphology1.07212284
42MP0009697_abnormal_copulation1.04315900
43MP0003186_abnormal_redox_activity1.02389220
44MP0002877_abnormal_melanocyte_morpholog1.01555076
45MP0006036_abnormal_mitochondrial_physio1.00928676
46* MP0009642_abnormal_blood_homeostasis1.00514579
47MP0002876_abnormal_thyroid_physiology0.99838568
48* MP0005535_abnormal_body_temperature0.93366669
49MP0001756_abnormal_urination0.93131262
50MP0005666_abnormal_adipose_tissue0.91710402
51* MP0002971_abnormal_brown_adipose0.91313976
52MP0004130_abnormal_muscle_cell0.90969516
53MP0003123_paternal_imprinting0.90622807
54MP0001661_extended_life_span0.90525594
55MP0005084_abnormal_gallbladder_morpholo0.89862722
56MP0002909_abnormal_adrenal_gland0.89847956
57MP0002132_abnormal_respiratory_system0.88967524
58* MP0005334_abnormal_fat_pad0.88961602
59MP0005058_abnormal_lysosome_morphology0.85946562
60MP0005647_abnormal_sex_gland0.85648917
61MP0005448_abnormal_energy_balance0.84825951
62* MP0003953_abnormal_hormone_level0.83045725
63MP0008872_abnormal_physiological_respon0.82950332
64MP0008469_abnormal_protein_level0.82650788
65* MP0009763_increased_sensitivity_to0.82143589
66MP0005167_abnormal_blood-brain_barrier0.80786953
67MP0005408_hypopigmentation0.77221518
68MP0003300_gastrointestinal_ulcer0.76577050
69MP0010368_abnormal_lymphatic_system0.76111015
70MP0003705_abnormal_hypodermis_morpholog0.74729833
71MP0005379_endocrine/exocrine_gland_phen0.73045401
72MP0003656_abnormal_erythrocyte_physiolo0.72758852
73MP0001765_abnormal_ion_homeostasis0.72292232
74MP0000604_amyloidosis0.71910107
75MP0009764_decreased_sensitivity_to0.71794400
76MP0002254_reproductive_system_inflammat0.70460560
77MP0003011_delayed_dark_adaptation0.70336564
78MP0000639_abnormal_adrenal_gland0.69369134
79MP0000013_abnormal_adipose_tissue0.66916707
80MP0005376_homeostasis/metabolism_phenot0.66014559
81MP0002089_abnormal_postnatal_growth/wei0.65225557
82MP0005551_abnormal_eye_electrophysiolog0.63295899
83MP0000230_abnormal_systemic_arterial0.63007123
84MP0005645_abnormal_hypothalamus_physiol0.62729062
85MP0005375_adipose_tissue_phenotype0.60735373
86MP0005266_abnormal_metabolism0.60378291
87MP0003724_increased_susceptibility_to0.59991330
88MP0009765_abnormal_xenobiotic_induced0.59698514
89MP0008961_abnormal_basal_metabolism0.58915015
90MP0003183_abnormal_peptide_metabolism0.58576657
91MP0000678_abnormal_parathyroid_gland0.57568821
92MP0009672_abnormal_birth_weight0.57089396
93* MP0005452_abnormal_adipose_tissue0.53668249
94MP0004270_analgesia0.53101719
95MP0002136_abnormal_kidney_physiology0.53081184
96MP0000462_abnormal_digestive_system0.52959978
97MP0005646_abnormal_pituitary_gland0.51917720
98MP0003329_amyloid_beta_deposits0.50493950
99MP0002168_other_aberrant_phenotype0.49760624
100MP0003075_altered_response_to0.49627614
101MP0002638_abnormal_pupillary_reflex0.48788637
102MP0001986_abnormal_taste_sensitivity0.48276924
103* MP0002970_abnormal_white_adipose0.48177953
104MP0000579_abnormal_nail_morphology0.47162484
105MP0003959_abnormal_lean_body0.47132171
106MP0003633_abnormal_nervous_system0.46266524
107MP0005395_other_phenotype0.45944745
108MP0005464_abnormal_platelet_physiology0.44684779
109MP0001915_intracranial_hemorrhage0.44562751
110MP0010386_abnormal_urinary_bladder0.44063321
111MP0004185_abnormal_adipocyte_glucose0.43656993
112MP0003690_abnormal_glial_cell0.42838552
113MP0002249_abnormal_larynx_morphology0.42360930
114MP0000003_abnormal_adipose_tissue0.41614051
115MP0000538_abnormal_urinary_bladder0.40805993
116MP0002069_abnormal_eating/drinking_beha0.40119166
117MP0004782_abnormal_surfactant_physiolog0.39693099
118MP0002269_muscular_atrophy0.39634734
119MP0009115_abnormal_fat_cell0.39073340
120MP0001501_abnormal_sleep_pattern0.38738238
121MP0005409_darkened_coat_color0.38328039
122MP0003638_abnormal_response/metabolism_0.38051633
123MP0005377_hearing/vestibular/ear_phenot0.37414139
124MP0003878_abnormal_ear_physiology0.37414139
125MP0006035_abnormal_mitochondrial_morpho0.35049933

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.06200465
2Intrahepatic cholestasis (HP:0001406)6.33530008
3Hypoglycemic coma (HP:0001325)6.01553376
4Deep venous thrombosis (HP:0002625)5.78151255
5Prolonged partial thromboplastin time (HP:0003645)5.71245560
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.62318495
7Xanthomatosis (HP:0000991)5.43678061
8Hypobetalipoproteinemia (HP:0003563)5.01895250
9Hypoglycemic seizures (HP:0002173)4.88185803
10Ketosis (HP:0001946)4.78892086
11Hyperinsulinemic hypoglycemia (HP:0000825)4.77953215
12Complement deficiency (HP:0004431)4.73057349
13Ketoacidosis (HP:0001993)4.54214438
14Hyperlipoproteinemia (HP:0010980)4.34359821
15Abnormality of the common coagulation pathway (HP:0010990)4.20637077
16Joint hemorrhage (HP:0005261)4.04309549
17Conjugated hyperbilirubinemia (HP:0002908)4.00638096
18Symptomatic seizures (HP:0011145)3.98977868
19Hyperglycinemia (HP:0002154)3.97094499
20Hyperammonemia (HP:0001987)3.94845079
21Abnormality of the intrinsic pathway (HP:0010989)3.94047142
22Epidermoid cyst (HP:0200040)3.92826941
23Hyperglycinuria (HP:0003108)3.91496541
24Hypolipoproteinemia (HP:0010981)3.85357125
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.78008086
26Fat malabsorption (HP:0002630)3.67800493
27Abnormality of glycine metabolism (HP:0010895)3.66585181
28Abnormality of serine family amino acid metabolism (HP:0010894)3.66585181
29Late onset (HP:0003584)3.56668288
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.50105551
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.47689813
32Hypoalphalipoproteinemia (HP:0003233)3.46464526
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.45294168
34Abnormality of complement system (HP:0005339)3.42197150
35Abnormality of fatty-acid metabolism (HP:0004359)3.36624425
36Generalized aminoaciduria (HP:0002909)3.36289525
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.35149792
38Hyperglycemia (HP:0003074)3.28252928
39Abnormality of methionine metabolism (HP:0010901)3.25387312
40Abnormality of purine metabolism (HP:0004352)3.16714526
41Gout (HP:0001997)3.14353554
42Abnormality of nucleobase metabolism (HP:0010932)3.04318418
43Hyperbilirubinemia (HP:0002904)3.03508674
44Nephritis (HP:0000123)3.03488601
45Hypercholesterolemia (HP:0003124)2.93409474
46Systemic lupus erythematosus (HP:0002725)2.87660275
47Abnormality of dicarboxylic acid metabolism (HP:0010995)2.86841888
48Dicarboxylic aciduria (HP:0003215)2.86841888
49Abnormality of the pancreatic islet cells (HP:0006476)2.86501161
50Abnormality of endocrine pancreas physiology (HP:0012093)2.86501161
51Skin nodule (HP:0200036)2.80410343
52Abnormality of pyrimidine metabolism (HP:0004353)2.79526202
53Metabolic acidosis (HP:0001942)2.73411810
54Cardiovascular calcification (HP:0011915)2.58986480
55Myocardial infarction (HP:0001658)2.58897025
56Abnormality of serum amino acid levels (HP:0003112)2.55366684
57Delayed CNS myelination (HP:0002188)2.54511919
58Steatorrhea (HP:0002570)2.52139892
59Irritability (HP:0000737)2.49089514
60Pancreatic islet-cell hyperplasia (HP:0004510)2.45436860
61Rickets (HP:0002748)2.45059802
62Glomerulonephritis (HP:0000099)2.44071420
63Purpura (HP:0000979)2.42582581
64Insulin-resistant diabetes mellitus (HP:0000831)2.42446170
65Hypophosphatemic rickets (HP:0004912)2.41233944
66Hepatocellular carcinoma (HP:0001402)2.40872177
67Gingival bleeding (HP:0000225)2.39874537
68Facial shape deformation (HP:0011334)2.37466272
69Potter facies (HP:0002009)2.37466272
70Recurrent gram-negative bacterial infections (HP:0005420)2.35816336
71Lethargy (HP:0001254)2.35435905
72Insulin resistance (HP:0000855)2.32793385
73Abnormality of vitamin metabolism (HP:0100508)2.30965906
74Enlarged kidneys (HP:0000105)2.30276100
75Abnormal gallbladder morphology (HP:0012437)2.29372328
76Mitral stenosis (HP:0001718)2.25945283
77Spontaneous abortion (HP:0005268)2.24951126
78Pancreatitis (HP:0001733)2.23366371
79Pigmentary retinal degeneration (HP:0001146)2.22555383
80Hyperphosphaturia (HP:0003109)2.20798665
81Abnormal enzyme/coenzyme activity (HP:0012379)2.17370529
82Glycosuria (HP:0003076)2.16034965
83Abnormality of urine glucose concentration (HP:0011016)2.16034965
84Hypochromic microcytic anemia (HP:0004840)2.13794004
85Abnormality of proline metabolism (HP:0010907)2.12839084
86Hydroxyprolinuria (HP:0003080)2.12839084
87Alkalosis (HP:0001948)2.12693479
88Acute hepatic failure (HP:0006554)2.11037604
89Malnutrition (HP:0004395)2.08482459
90Renal cortical cysts (HP:0000803)2.07920211
91Vascular calcification (HP:0004934)2.07430244
92Thrombophlebitis (HP:0004418)2.06420986
93Hyperuricemia (HP:0002149)2.06252225
94Increased purine levels (HP:0004368)2.06252225
95Elevated alkaline phosphatase (HP:0003155)2.05655460
96Arthropathy (HP:0003040)2.03841538
97Mucopolysacchariduria (HP:0008155)2.03742023
98Urinary glycosaminoglycan excretion (HP:0003541)2.03742023
99Myoglobinuria (HP:0002913)2.03672564
100Proximal tubulopathy (HP:0000114)2.02653058
101Cholelithiasis (HP:0001081)2.02289288
102Cerebral edema (HP:0002181)2.01223101
103Sensorimotor neuropathy (HP:0007141)2.00579054
104Abnormality of alkaline phosphatase activity (HP:0004379)1.99729704
105Vomiting (HP:0002013)1.99411724
106Menorrhagia (HP:0000132)1.98428955
107Brushfield spots (HP:0001088)1.95759672
108Acanthocytosis (HP:0001927)1.94061101
109Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93438810
110Abnormality of polysaccharide metabolism (HP:0011012)1.93438810
111Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93438810
112Increased serum pyruvate (HP:0003542)1.92199514
113Abnormal urine phosphate concentration (HP:0012599)1.91935957
114Widely patent fontanelles and sutures (HP:0004492)1.90005343
115Neonatal onset (HP:0003623)1.89355491
116Limb hypertonia (HP:0002509)1.87671092
117Hemorrhage of the eye (HP:0011885)1.87653719
118Pulmonary embolism (HP:0002204)1.87444422
119Retinal atrophy (HP:0001105)1.85928618
120Megaloblastic anemia (HP:0001889)1.84639709
121Hypertriglyceridemia (HP:0002155)1.82557118
122Hypothermia (HP:0002045)1.78193806
123Osteomalacia (HP:0002749)1.76820647
124Hypophosphatemia (HP:0002148)1.74737651
125Abnormality of glycolysis (HP:0004366)1.68803635
126Bifid scrotum (HP:0000048)1.68378950
127Fair hair (HP:0002286)1.67859739
128Poikilocytosis (HP:0004447)1.61707338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.56570380
2BCKDK5.02573998
3ERN14.62183445
4MAPK153.73712562
5TAOK33.64126736
6SIK13.62092354
7FGFR23.23873912
8FGFR43.23844182
9PASK3.12864782
10NTRK32.88941636
11FLT32.68413818
12ACVR1B2.15847910
13TRIB31.98556749
14MST1R1.84663729
15IRAK31.77431072
16PHKG11.74246763
17PHKG21.74246763
18FRK1.68184125
19ERBB41.61950966
20PIK3CG1.57719898
21PTK61.53598763
22ICK1.50895809
23MAPK111.40116461
24PKN21.38832450
25MET1.36951985
26HIPK21.34513974
27CAMK1D1.29743283
28EPHA41.28563020
29MAPKAPK31.28540598
30LATS11.28299754
31SGK4941.25995521
32SGK2231.25995521
33MAP2K41.18031770
34EPHA31.14045347
35PRKCG1.12320003
36PRKAA21.12265609
37TYRO31.09204600
38TYK21.08928978
39GRK11.07321934
40DYRK1B1.06802185
41JAK21.05204267
42WNK41.05138870
43MAP3K21.03218062
44PTK21.01491014
45WNK10.98962850
46CAMK1G0.98222057
47STK390.94272675
48IRAK10.93406227
49DDR20.92581986
50SGK10.89302987
51JAK10.89274750
52MAP2K30.88725156
53FGFR10.88263963
54PRKAA10.87091389
55MAP3K10.85799737
56PRKG20.85731653
57EPHB10.85293222
58PDK10.84384071
59MAP3K70.79902417
60PINK10.79597184
61RIPK10.79511766
62MAP3K30.79100182
63STK38L0.77829856
64TGFBR20.77825180
65EPHA20.77123912
66FER0.77091943
67PRKG10.73543916
68NEK90.72224314
69TBK10.71987170
70PDGFRA0.71454530
71NTRK10.70371266
72CSK0.69743629
73ERBB20.68472548
74MAP2K20.67418452
75GSK3A0.65870097
76CAMK10.65802653
77DAPK20.63667681
78PRKACG0.63208048
79CASK0.62370281
80MAP3K100.60573158
81BMPR1B0.60140728
82* PRKACA0.59216224
83ADRBK20.58341659
84RPS6KA30.57594122
85IRAK20.56814592
86PRKD30.56709141
87ZAP700.54671663
88PDK20.54473439
89PRKCZ0.51551380
90MAP2K60.51535189
91LMTK20.51286339
92MAP3K60.50617569
93IGF1R0.50238504
94NTRK20.49146940
95CSNK1E0.49142255
96MTOR0.49047654
97PRKCH0.48738019
98NUAK10.48304645
99OBSCN0.47884840
100NME10.47694899
101MAP3K140.47010766
102ABL20.46953439
103RET0.46341186
104PDPK10.46119022
105CAMK2D0.45061915
106TIE10.43940348
107CDK120.42859800
108ITK0.42435938
109NLK0.41894794
110PIK3CA0.41392255
111PAK30.41211845
112SGK30.40227390
113CHUK0.39222076
114CSNK1A10.39088305
115JAK30.39051284
116SIK20.38078377
117CSNK1D0.37502273
118PRKACB0.37483686
119MAP4K20.36365688
120SRC0.35774322
121WNK30.35590948
122TNK20.34798632
123PRKD20.33838835
124CAMKK20.33686526
125CSF1R0.33563135
126KDR0.32558886
127MAP2K10.31322401
128AKT30.30898720
129FGFR30.30249947
130MAP3K110.29135151
131CAMK2G0.28392380
132SGK20.28124177
133EIF2AK30.27625808
134MAPK70.27215347
135MAPK40.26485457
136CDC42BPA0.25521093
137MAPK120.24676385
138PDK30.24372736
139PDK40.24372736
140CAMK40.21413993
141CDK60.21352149
142PRKD10.19415522
143IKBKE0.18652137
144PRKCA0.18265508
145MAPK30.18069906

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.96928119
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.49169038
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.09981478
4Nitrogen metabolism_Homo sapiens_hsa009103.06055631
5Tryptophan metabolism_Homo sapiens_hsa003802.91817591
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.72139862
7Fatty acid degradation_Homo sapiens_hsa000712.62459534
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.62363402
9Arginine biosynthesis_Homo sapiens_hsa002202.54015244
10Complement and coagulation cascades_Homo sapiens_hsa046102.43763253
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.42809592
12Butanoate metabolism_Homo sapiens_hsa006502.37596875
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34136501
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19861553
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.17992603
16Sulfur metabolism_Homo sapiens_hsa009202.11884781
17Selenocompound metabolism_Homo sapiens_hsa004502.07760954
18Peroxisome_Homo sapiens_hsa041462.04324888
19Propanoate metabolism_Homo sapiens_hsa006401.97937079
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97415003
21Histidine metabolism_Homo sapiens_hsa003401.96098101
22Fatty acid metabolism_Homo sapiens_hsa012121.90725648
23PPAR signaling pathway_Homo sapiens_hsa033201.80703833
24Staphylococcus aureus infection_Homo sapiens_hsa051501.67724796
25Chemical carcinogenesis_Homo sapiens_hsa052041.64094398
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.63941132
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.63631337
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61494713
29beta-Alanine metabolism_Homo sapiens_hsa004101.59844239
30Phenylalanine metabolism_Homo sapiens_hsa003601.53774422
31Starch and sucrose metabolism_Homo sapiens_hsa005001.51940742
32Folate biosynthesis_Homo sapiens_hsa007901.50367284
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49143971
34ABC transporters_Homo sapiens_hsa020101.47227630
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47083711
36Retinol metabolism_Homo sapiens_hsa008301.46886862
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43018762
38Bile secretion_Homo sapiens_hsa049761.42895226
39Caffeine metabolism_Homo sapiens_hsa002321.41192896
40Tyrosine metabolism_Homo sapiens_hsa003501.40477320
41Fatty acid elongation_Homo sapiens_hsa000621.37482502
42Pyruvate metabolism_Homo sapiens_hsa006201.36242413
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36029269
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34990344
45Fat digestion and absorption_Homo sapiens_hsa049751.29920910
46Lysine degradation_Homo sapiens_hsa003101.09655211
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03717545
48Carbon metabolism_Homo sapiens_hsa012001.02928373
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96389036
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.93509670
51Arginine and proline metabolism_Homo sapiens_hsa003300.92189707
52Steroid biosynthesis_Homo sapiens_hsa001000.89714527
53Biosynthesis of amino acids_Homo sapiens_hsa012300.89004571
54Vitamin digestion and absorption_Homo sapiens_hsa049770.84373218
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82798351
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76868142
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75742036
58Glycerolipid metabolism_Homo sapiens_hsa005610.73037698
59Sulfur relay system_Homo sapiens_hsa041220.70954217
60Protein export_Homo sapiens_hsa030600.70288662
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69289140
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.68390546
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66959201
64Vitamin B6 metabolism_Homo sapiens_hsa007500.63611931
65Renin-angiotensin system_Homo sapiens_hsa046140.61102837
66Mineral absorption_Homo sapiens_hsa049780.60301951
67Galactose metabolism_Homo sapiens_hsa000520.59946264
68One carbon pool by folate_Homo sapiens_hsa006700.50898032
69Glutathione metabolism_Homo sapiens_hsa004800.49457439
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47750710
71* Insulin resistance_Homo sapiens_hsa049310.46877962
72Metabolic pathways_Homo sapiens_hsa011000.46716738
73Prion diseases_Homo sapiens_hsa050200.46218160
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.41953151
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40435014
76Pentose phosphate pathway_Homo sapiens_hsa000300.38682530
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38071327
78Fatty acid biosynthesis_Homo sapiens_hsa000610.37974820
79Glucagon signaling pathway_Homo sapiens_hsa049220.37897890
80Type II diabetes mellitus_Homo sapiens_hsa049300.37562164
81Fructose and mannose metabolism_Homo sapiens_hsa000510.35975218
82Linoleic acid metabolism_Homo sapiens_hsa005910.32872592
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.32600359
84Other glycan degradation_Homo sapiens_hsa005110.29994645
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.25898775
86Pertussis_Homo sapiens_hsa051330.25480153
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20500336
88Insulin secretion_Homo sapiens_hsa049110.20480952
89AMPK signaling pathway_Homo sapiens_hsa041520.16741836
90Sphingolipid metabolism_Homo sapiens_hsa006000.15490238
91Lysosome_Homo sapiens_hsa041420.14604490
92Regulation of autophagy_Homo sapiens_hsa041400.14210257
93Ether lipid metabolism_Homo sapiens_hsa005650.12615812
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10479711
95Protein digestion and absorption_Homo sapiens_hsa049740.09059456
96Insulin signaling pathway_Homo sapiens_hsa049100.08031489
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06257330
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.05502003
99Circadian rhythm_Homo sapiens_hsa047100.05330798
100* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02171234
101Renin secretion_Homo sapiens_hsa049240.01569479
102Prolactin signaling pathway_Homo sapiens_hsa04917-0.1171242
103Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1110229
104Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0888755
105Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0466461
106Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0347160
107Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0190820
108Serotonergic synapse_Homo sapiens_hsa04726-0.0086402
109Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0019023
110N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0015583

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