MMAA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in the translocation of cobalamin into the mitochondrion, where it is used in the final steps of adenosylcobalamin synthesis. Adenosylcobalamin is a coenzyme required for the activity of methylmalonyl-CoA mutase. Defects in this gene are a cause of methylmalonic aciduria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.11920364
2L-phenylalanine catabolic process (GO:0006559)5.11920364
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.01812079
4L-phenylalanine metabolic process (GO:0006558)5.01812079
5aromatic amino acid family catabolic process (GO:0009074)4.37210465
6cellular ketone body metabolic process (GO:0046950)4.32057889
7pyrimidine nucleobase catabolic process (GO:0006208)4.22445362
8piRNA metabolic process (GO:0034587)4.11313029
9kynurenine metabolic process (GO:0070189)4.06067741
10nucleobase catabolic process (GO:0046113)4.03854950
11lysine catabolic process (GO:0006554)3.96712943
12lysine metabolic process (GO:0006553)3.96712943
13establishment of protein localization to Golgi (GO:0072600)3.96458987
14regulation of cilium movement (GO:0003352)3.95071562
15* short-chain fatty acid metabolic process (GO:0046459)3.93099933
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.79703870
17indole-containing compound catabolic process (GO:0042436)3.78249855
18indolalkylamine catabolic process (GO:0046218)3.78249855
19tryptophan catabolic process (GO:0006569)3.78249855
20aspartate family amino acid catabolic process (GO:0009068)3.74910007
21exogenous drug catabolic process (GO:0042738)3.73832025
22glyoxylate metabolic process (GO:0046487)3.73562345
23protein targeting to Golgi (GO:0000042)3.72331916
24ketone body metabolic process (GO:1902224)3.69406759
25* fatty acid beta-oxidation (GO:0006635)3.68875440
26bile acid biosynthetic process (GO:0006699)3.65589670
27serine family amino acid catabolic process (GO:0009071)3.63242605
28branched-chain amino acid catabolic process (GO:0009083)3.63127698
29sulfur amino acid catabolic process (GO:0000098)3.61982581
30acetyl-CoA metabolic process (GO:0006084)3.60846652
31coenzyme catabolic process (GO:0009109)3.60077815
32amine catabolic process (GO:0009310)3.59178847
33cellular biogenic amine catabolic process (GO:0042402)3.59178847
34NADH metabolic process (GO:0006734)3.58349059
35amino-acid betaine metabolic process (GO:0006577)3.57994426
36retrograde transport, vesicle recycling within Golgi (GO:0000301)3.56164952
37regulation of triglyceride catabolic process (GO:0010896)3.54483410
382-oxoglutarate metabolic process (GO:0006103)3.51863408
39S-adenosylmethionine metabolic process (GO:0046500)3.50947022
40* fatty acid catabolic process (GO:0009062)3.50862593
41tryptophan metabolic process (GO:0006568)3.48864951
42alpha-linolenic acid metabolic process (GO:0036109)3.46951809
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.46236313
44protein polyglutamylation (GO:0018095)3.46118180
45* fatty acid oxidation (GO:0019395)3.44002464
46biotin metabolic process (GO:0006768)3.43808439
47sulfation (GO:0051923)3.42372992
48alpha-amino acid catabolic process (GO:1901606)3.41473182
49carnitine shuttle (GO:0006853)3.41196503
50dicarboxylic acid biosynthetic process (GO:0043650)3.40080298
51succinate metabolic process (GO:0006105)3.39263993
52* lipid oxidation (GO:0034440)3.36863643
53fatty acid transmembrane transport (GO:1902001)3.36368080
54cysteine metabolic process (GO:0006534)3.34127826
55cellular amino acid catabolic process (GO:0009063)3.33685981
56* monocarboxylic acid catabolic process (GO:0072329)3.32905981
57tricarboxylic acid cycle (GO:0006099)3.31951268
58glutamate metabolic process (GO:0006536)3.27337146
59urea cycle (GO:0000050)3.26488821
60urea metabolic process (GO:0019627)3.26488821
61aromatic amino acid family metabolic process (GO:0009072)3.26426015
62retinal cone cell development (GO:0046549)3.22329230
63* carboxylic acid catabolic process (GO:0046395)3.16500814
64* organic acid catabolic process (GO:0016054)3.16500814
65branched-chain amino acid metabolic process (GO:0009081)3.16401048
66auditory receptor cell differentiation (GO:0042491)3.14644299
67negative regulation of mast cell activation (GO:0033004)3.12315843
68dicarboxylic acid catabolic process (GO:0043649)3.12157195
69bile acid metabolic process (GO:0008206)3.10510217
70amino acid salvage (GO:0043102)3.08848655
71L-methionine salvage (GO:0071267)3.08848655
72L-methionine biosynthetic process (GO:0071265)3.08848655
73triglyceride homeostasis (GO:0070328)3.08507036
74acylglycerol homeostasis (GO:0055090)3.08507036
75mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.07532395
76benzene-containing compound metabolic process (GO:0042537)3.07108688
77carnitine metabolic process (GO:0009437)3.05726888
78oxidative demethylation (GO:0070989)3.05664475
79nitrogen cycle metabolic process (GO:0071941)3.05663859
80nonmotile primary cilium assembly (GO:0035058)3.04994047
81ethanol oxidation (GO:0006069)3.04879964
82high-density lipoprotein particle remodeling (GO:0034375)3.04835212
83regulation of sequestering of triglyceride (GO:0010889)3.04427634
84righting reflex (GO:0060013)3.03076090
85detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.01469226
86regulation of meiosis I (GO:0060631)3.00131339
87multicellular organism reproduction (GO:0032504)2.98147359
88negative regulation of lipase activity (GO:0060192)2.96480256
89DNA methylation involved in gamete generation (GO:0043046)2.95370619
90homocysteine metabolic process (GO:0050667)2.94922256
91mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.94602282
92regulation of acrosome reaction (GO:0060046)2.92730890
93xenobiotic catabolic process (GO:0042178)2.92555336
94signal peptide processing (GO:0006465)2.92551906
95tyrosine metabolic process (GO:0006570)2.91457326
96methionine biosynthetic process (GO:0009086)2.90005366
97methionine metabolic process (GO:0006555)2.89663369
98thioester metabolic process (GO:0035383)2.87571097
99acyl-CoA metabolic process (GO:0006637)2.87571097
100gamma-aminobutyric acid transport (GO:0015812)2.87169033
101respiratory electron transport chain (GO:0022904)2.85659119
102regulation of fibrinolysis (GO:0051917)2.85556537
103NAD metabolic process (GO:0019674)2.85247032
104regulation of acyl-CoA biosynthetic process (GO:0050812)2.83858292
105positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.81216827
106regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.81202008
107photoreceptor cell maintenance (GO:0045494)2.80503308
108regulation of fatty acid oxidation (GO:0046320)2.80216367
109indolalkylamine metabolic process (GO:0006586)2.79207636
110negative regulation of fibrinolysis (GO:0051918)2.79184295
111L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79129724
112acyl-CoA biosynthetic process (GO:0071616)2.78603050
113thioester biosynthetic process (GO:0035384)2.78603050
114electron transport chain (GO:0022900)2.78286558
115omega-hydroxylase P450 pathway (GO:0097267)2.77950561
116positive regulation of fatty acid oxidation (GO:0046321)2.77769471
117energy coupled proton transport, down electrochemical gradient (GO:0015985)2.77297771
118ATP synthesis coupled proton transport (GO:0015986)2.77297771
119epoxygenase P450 pathway (GO:0019373)2.76891394
120carnitine transmembrane transport (GO:1902603)2.75995220
121regulation of protein activation cascade (GO:2000257)2.74875147
122cellular modified amino acid catabolic process (GO:0042219)2.74736327
123protein targeting to vacuole (GO:0006623)2.74551264
124protein targeting to lysosome (GO:0006622)2.74551264
125establishment of protein localization to vacuole (GO:0072666)2.74551264
126oxaloacetate metabolic process (GO:0006107)2.72893789
127cellular glucuronidation (GO:0052695)2.72107529
128regulation of mitochondrial fission (GO:0090140)2.71530372
129carnitine transport (GO:0015879)2.71222994
130amino-acid betaine transport (GO:0015838)2.71222994
131* small molecule catabolic process (GO:0044282)2.70693251
132complement activation, alternative pathway (GO:0006957)2.69069032
133peptidyl-glutamic acid carboxylation (GO:0017187)2.68497336
134protein carboxylation (GO:0018214)2.68497336
135detection of light stimulus involved in visual perception (GO:0050908)2.68267626
136detection of light stimulus involved in sensory perception (GO:0050962)2.68267626
137negative regulation of systemic arterial blood pressure (GO:0003085)2.67713752
138reflex (GO:0060004)2.67118343
139regulation of microtubule-based movement (GO:0060632)2.65869333
140positive regulation of lipid catabolic process (GO:0050996)2.63520731
141drug catabolic process (GO:0042737)2.62205312
142ventricular cardiac muscle cell action potential (GO:0086005)2.61998058
143regulation of bile acid biosynthetic process (GO:0070857)2.61375709
144indole-containing compound metabolic process (GO:0042430)2.60761536
145cofactor catabolic process (GO:0051187)2.60568827
146positive regulation of fatty acid beta-oxidation (GO:0032000)2.60039486
147phospholipid homeostasis (GO:0055091)2.60035530
148NAD biosynthetic process (GO:0009435)2.58062573
149intra-Golgi vesicle-mediated transport (GO:0006891)2.57595071
150fucose catabolic process (GO:0019317)2.57542695
151L-fucose metabolic process (GO:0042354)2.57542695
152L-fucose catabolic process (GO:0042355)2.57542695
153G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56521009
154brain morphogenesis (GO:0048854)2.56341141
155negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55843185
156RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55165324
157protein localization to Golgi apparatus (GO:0034067)2.54637790
158response to nitrosative stress (GO:0051409)2.54306957
159anterograde synaptic vesicle transport (GO:0048490)2.50917489
160interleukin-6-mediated signaling pathway (GO:0070102)2.50897310
161alkaloid metabolic process (GO:0009820)2.50741448
162positive regulation of mitochondrial fission (GO:0090141)2.50179217
163glucuronate metabolic process (GO:0019585)2.47294316
164uronic acid metabolic process (GO:0006063)2.47294316
165neural tube formation (GO:0001841)2.46577718
166nitric oxide biosynthetic process (GO:0006809)2.44536311
167positive regulation of amino acid transport (GO:0051957)2.43486052
168mRNA modification (GO:0016556)2.43329749
169cilium morphogenesis (GO:0060271)2.40936184
170retinal rod cell development (GO:0046548)2.40555791
171startle response (GO:0001964)2.38919692
172N-acetylglucosamine metabolic process (GO:0006044)2.38358320
173photoreceptor cell development (GO:0042461)2.37931180
174presynaptic membrane assembly (GO:0097105)2.37471282
175adaptation of signaling pathway (GO:0023058)2.35911900
176protein K11-linked deubiquitination (GO:0035871)2.33937584
177meiotic cell cycle (GO:0051321)2.33446497
178mechanosensory behavior (GO:0007638)2.31564578
179dopamine transport (GO:0015872)2.30138000
180gene silencing by RNA (GO:0031047)2.28826679
181phenylpropanoid metabolic process (GO:0009698)2.27898045
182serotonin metabolic process (GO:0042428)2.26623431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.47189730
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.92744766
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.78552638
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.56039148
5EZH2_22144423_ChIP-Seq_EOC_Human3.49076807
6IGF1R_20145208_ChIP-Seq_DFB_Human3.47650067
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.22113164
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.09875512
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.03917211
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.81704648
11GBX2_23144817_ChIP-Seq_PC3_Human2.72123441
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.46119677
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.38555192
14VDR_22108803_ChIP-Seq_LS180_Human2.23807774
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10194747
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.07844764
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.05963633
18GATA1_22025678_ChIP-Seq_K562_Human2.05368460
19* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.04243348
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02571270
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.01281785
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92159435
23ER_23166858_ChIP-Seq_MCF-7_Human1.85829409
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80005251
25EWS_26573619_Chip-Seq_HEK293_Human1.77187882
26TAF15_26573619_Chip-Seq_HEK293_Human1.76770147
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70435248
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70339893
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68110794
30FUS_26573619_Chip-Seq_HEK293_Human1.67596239
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65658603
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.64644807
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58756869
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58146681
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58146681
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56106991
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55499788
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55118120
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51053033
40TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50931030
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49390886
42DROSHA_22980978_ChIP-Seq_HELA_Human1.48951144
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.48643132
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.48150711
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.46505815
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46321079
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45871221
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44677445
49HTT_18923047_ChIP-ChIP_STHdh_Human1.44373344
50ZNF274_21170338_ChIP-Seq_K562_Hela1.42645918
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41289871
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37381694
53REST_21632747_ChIP-Seq_MESCs_Mouse1.36850281
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.36536398
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36198273
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.36172275
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35464842
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.34994923
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.34406740
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33813939
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33802471
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.32147694
63SOX2_19829295_ChIP-Seq_ESCs_Human1.30623256
64NANOG_19829295_ChIP-Seq_ESCs_Human1.30623256
65IRF8_22096565_ChIP-ChIP_GC-B_Human1.29523569
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29285216
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28670711
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27004367
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.26026876
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.25839286
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25749247
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.25161737
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.23858337
74BCAT_22108803_ChIP-Seq_LS180_Human1.22240878
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.21055459
76CDX2_22108803_ChIP-Seq_LS180_Human1.20895962
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19867525
78* TAL1_26923725_Chip-Seq_HPCs_Mouse1.19069963
79TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.17942227
80* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17489747
81P53_22387025_ChIP-Seq_ESCs_Mouse1.16876886
82* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16742275
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.15415855
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.14902257
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13916629
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13537807
87* SMAD4_21799915_ChIP-Seq_A2780_Human1.13434944
88TP53_22573176_ChIP-Seq_HFKS_Human1.13220827
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.11380997
90TP53_18474530_ChIP-ChIP_U2OS_Human1.11235394
91TCF4_22108803_ChIP-Seq_LS180_Human1.10049159
92* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10037250
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09876255
94OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09430370
95IRF8_21731497_ChIP-ChIP_J774_Mouse1.08305085
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08195972
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07262912
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07172475
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07172475
100FOXA2_19822575_ChIP-Seq_HepG2_Human1.06851401
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06002068
102RNF2_27304074_Chip-Seq_ESCs_Mouse1.05210842
103KDM2B_26808549_Chip-Seq_REH_Human1.05105613
104AR_21572438_ChIP-Seq_LNCaP_Human1.04358079
105CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04101091
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03805324
107SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03536484
108P300_19829295_ChIP-Seq_ESCs_Human1.02733226
109STAT3_18555785_Chip-Seq_ESCs_Mouse1.00915829
110TP53_16413492_ChIP-PET_HCT116_Human1.00874413
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.00770873
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00744958
113MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99029556
114AR_25329375_ChIP-Seq_VCAP_Human0.98910039
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98567285
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97545205
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97287630
118CMYC_18555785_Chip-Seq_ESCs_Mouse0.96178390
119FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95427629
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95271696
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94548330
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94056730
123SOX2_21211035_ChIP-Seq_LN229_Gbm0.93900547
124FOXA1_25329375_ChIP-Seq_VCAP_Human0.93237909
125FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93237909
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.92402558
127P300_18555785_Chip-Seq_ESCs_Mouse0.92249251
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90295542
129NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89027550
130AHR_22903824_ChIP-Seq_MCF-7_Human0.87449346
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86869064
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86869064
133POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84698366
134CTCF_27219007_Chip-Seq_Bcells_Human0.82897906
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81599820
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80391849
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80246380
138HNF4A_19822575_ChIP-Seq_HepG2_Human0.80076534
139AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79865144
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79323737
141ESR2_21235772_ChIP-Seq_MCF-7_Human0.79190721
142STAT3_23295773_ChIP-Seq_U87_Human0.79001439
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.78167790
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77044438
145DNAJC2_21179169_ChIP-ChIP_NT2_Human0.75963184
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.75214123
147TCF4_23295773_ChIP-Seq_U87_Human0.74519680
148PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73291611
149OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.72134376
150CBP_21632823_ChIP-Seq_H3396_Human0.71904747
151* AR_19668381_ChIP-Seq_PC3_Human0.71305326
152IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.71056069
153CBP_20019798_ChIP-Seq_JUKART_Human0.71056069
154PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.70660917
155MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.70257523
156THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.69838001
157HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69811210
158SMAD4_21741376_ChIP-Seq_EPCs_Human0.69621569
159RUNX2_22187159_ChIP-Seq_PCA_Human0.69421195

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.79304949
2MP0005360_urolithiasis4.41367642
3MP0005365_abnormal_bile_salt4.03466094
4MP0005085_abnormal_gallbladder_physiolo3.98142553
5MP0002837_dystrophic_cardiac_calcinosis3.92015763
6MP0008875_abnormal_xenobiotic_pharmacok3.88719066
7MP0003183_abnormal_peptide_metabolism3.20695321
8MP0002138_abnormal_hepatobiliary_system3.18555964
9MP0000569_abnormal_digit_pigmentation2.97297448
10MP0008877_abnormal_DNA_methylation2.58547008
11MP0003646_muscle_fatigue2.58470745
12MP0000751_myopathy2.42683557
13MP0004215_abnormal_myocardial_fiber2.37910012
14MP0010329_abnormal_lipoprotein_level2.23810830
15MP0005332_abnormal_amino_acid2.17337906
16MP0004859_abnormal_synaptic_plasticity2.13675097
17MP0003806_abnormal_nucleotide_metabolis2.11696664
18MP0003718_maternal_effect2.08461117
19MP0004130_abnormal_muscle_cell2.00493954
20MP0003252_abnormal_bile_duct1.99475650
21MP0003195_calcinosis1.97071305
22MP0005083_abnormal_biliary_tract1.94385323
23MP0003880_abnormal_central_pattern1.87160263
24MP0001666_abnormal_nutrient_absorption1.82786535
25MP0006036_abnormal_mitochondrial_physio1.77344426
26MP0008789_abnormal_olfactory_epithelium1.73038624
27MP0004036_abnormal_muscle_relaxation1.70848009
28MP0003635_abnormal_synaptic_transmissio1.64740193
29MP0002822_catalepsy1.63955061
30MP0002118_abnormal_lipid_homeostasis1.61068079
31MP0009840_abnormal_foam_cell1.60073022
32MP0003137_abnormal_impulse_conducting1.56641350
33MP0005330_cardiomyopathy1.56535153
34MP0004084_abnormal_cardiac_muscle1.52650749
35MP0004043_abnormal_pH_regulation1.50212677
36MP0004270_analgesia1.48386451
37MP0009745_abnormal_behavioral_response1.45070023
38MP0000749_muscle_degeneration1.44273213
39MP0010386_abnormal_urinary_bladder1.43138912
40MP0005423_abnormal_somatic_nervous1.42771759
41MP0000427_abnormal_hair_cycle1.42130577
42MP0006054_spinal_hemorrhage1.41300979
43MP0004019_abnormal_vitamin_homeostasis1.40954199
44MP0005084_abnormal_gallbladder_morpholo1.40620219
45MP0005584_abnormal_enzyme/coenzyme_acti1.39961226
46MP0005670_abnormal_white_adipose1.38447557
47MP0004145_abnormal_muscle_electrophysio1.38299025
48MP0005535_abnormal_body_temperature1.37035450
49MP0009780_abnormal_chondrocyte_physiolo1.35052799
50MP0002102_abnormal_ear_morphology1.34273496
51MP0002064_seizures1.33714173
52MP0002063_abnormal_learning/memory/cond1.30124596
53MP0003868_abnormal_feces_composition1.29540916
54MP0004085_abnormal_heartbeat1.28902728
55MP0003329_amyloid_beta_deposits1.27202725
56MP0001764_abnormal_homeostasis1.25438931
57MP0005645_abnormal_hypothalamus_physiol1.23320100
58MP0001986_abnormal_taste_sensitivity1.23230501
59MP0006035_abnormal_mitochondrial_morpho1.22925878
60MP0006276_abnormal_autonomic_nervous1.22922243
61MP0003191_abnormal_cellular_cholesterol1.22725243
62MP0001501_abnormal_sleep_pattern1.22534501
63MP0002272_abnormal_nervous_system1.21938889
64MP0001440_abnormal_grooming_behavior1.21379690
65MP0002572_abnormal_emotion/affect_behav1.20546895
66MP0001529_abnormal_vocalization1.20186317
67MP0003633_abnormal_nervous_system1.19481304
68MP0005266_abnormal_metabolism1.19008634
69MP0005499_abnormal_olfactory_system1.18644524
70MP0005394_taste/olfaction_phenotype1.18644524
71MP0001486_abnormal_startle_reflex1.18206389
72MP0001485_abnormal_pinna_reflex1.17576328
73MP0002876_abnormal_thyroid_physiology1.17250723
74MP0005187_abnormal_penis_morphology1.16465980
75MP0000013_abnormal_adipose_tissue1.15651340
76MP0005620_abnormal_muscle_contractility1.15322241
77MP0009764_decreased_sensitivity_to1.14901063
78MP0009046_muscle_twitch1.12891355
79MP0003011_delayed_dark_adaptation1.12243284
80MP0001968_abnormal_touch/_nociception1.11935393
81MP0005319_abnormal_enzyme/_coenzyme1.10623230
82MP0004147_increased_porphyrin_level1.10203265
83MP0002972_abnormal_cardiac_muscle1.08502087
84MP0006082_CNS_inflammation1.08244017
85MP0000747_muscle_weakness1.07611113
86MP0005666_abnormal_adipose_tissue1.06781311
87MP0004742_abnormal_vestibular_system1.06315280
88MP0005395_other_phenotype1.02768256
89MP0005647_abnormal_sex_gland1.01934775
90MP0004484_altered_response_of1.01848685
91MP0002928_abnormal_bile_duct1.01666328
92MP0008775_abnormal_heart_ventricle1.00737419
93MP0000609_abnormal_liver_physiology1.00716367
94MP0005410_abnormal_fertilization1.00289232
95MP0004087_abnormal_muscle_fiber0.99538720
96MP0004924_abnormal_behavior0.98112626
97MP0005386_behavior/neurological_phenoty0.98112626
98MP0002078_abnormal_glucose_homeostasis0.98082922
99MP0008057_abnormal_DNA_replication0.97747468
100MP0001984_abnormal_olfaction0.97507031
101MP0006072_abnormal_retinal_apoptosis0.96268181
102MP0000230_abnormal_systemic_arterial0.95746948
103MP0005253_abnormal_eye_physiology0.95436110
104MP0003879_abnormal_hair_cell0.93993394
105MP0002735_abnormal_chemical_nociception0.92935903
106MP0002736_abnormal_nociception_after0.92512495
107MP0002971_abnormal_brown_adipose0.92022942
108MP0003656_abnormal_erythrocyte_physiolo0.91362467
109MP0005551_abnormal_eye_electrophysiolog0.90531683
110MP0005385_cardiovascular_system_phenoty0.90487325
111MP0001544_abnormal_cardiovascular_syste0.90487325
112MP0000015_abnormal_ear_pigmentation0.90400363
113MP0002909_abnormal_adrenal_gland0.90348973
114MP0005451_abnormal_body_composition0.90032658
115MP0000516_abnormal_urinary_system0.89812370
116MP0005367_renal/urinary_system_phenotyp0.89812370
117MP0002269_muscular_atrophy0.89480691
118MP0003724_increased_susceptibility_to0.89418714
119MP0002067_abnormal_sensory_capabilities0.89328310
120MP0002734_abnormal_mechanical_nocicepti0.88969510
121MP0002332_abnormal_exercise_endurance0.86634876
122MP0002693_abnormal_pancreas_physiology0.86306947
123MP0006138_congestive_heart_failure0.85887929
124MP0010678_abnormal_skin_adnexa0.85735827
125MP0005310_abnormal_salivary_gland0.85590856
126MP0002106_abnormal_muscle_physiology0.82674778
127MP0005636_abnormal_mineral_homeostasis0.81165378
128MP0009643_abnormal_urine_homeostasis0.80471637
129MP0001765_abnormal_ion_homeostasis0.80453643
130MP0001905_abnormal_dopamine_level0.79825814
131MP0001944_abnormal_pancreas_morphology0.79038986
132MP0002229_neurodegeneration0.78468348
133MP0005448_abnormal_energy_balance0.78315744
134MP0000685_abnormal_immune_system0.78054950
135MP0009697_abnormal_copulation0.77830590
136MP0005375_adipose_tissue_phenotype0.77489745
137MP0010234_abnormal_vibrissa_follicle0.77209804
138MP0005389_reproductive_system_phenotype0.76372977
139MP0003631_nervous_system_phenotype0.75853347
140MP0005334_abnormal_fat_pad0.75761973
141MP0008874_decreased_physiological_sensi0.75459678
142MP0005646_abnormal_pituitary_gland0.75382901
143MP0001919_abnormal_reproductive_system0.75108900
144MP0004142_abnormal_muscle_tone0.75048307
145MP0008872_abnormal_physiological_respon0.74734345
146MP0009785_altered_susceptibility_to0.72493721
147MP0003045_fibrosis0.69554090
148MP0004885_abnormal_endolymph0.68951354
149MP0000383_abnormal_hair_follicle0.66903986
150MP0003959_abnormal_lean_body0.65930054

Predicted human phenotypes

RankGene SetZ-score
1Renal cortical cysts (HP:0000803)4.80134528
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.42266769
3* Ketosis (HP:0001946)4.33634208
4Ketoacidosis (HP:0001993)4.20679463
5* Hyperglycinemia (HP:0002154)3.94922038
6Hyperglycinuria (HP:0003108)3.90554017
7* Abnormality of serine family amino acid metabolism (HP:0010894)3.84393853
8* Abnormality of glycine metabolism (HP:0010895)3.84393853
9Hyperlipoproteinemia (HP:0010980)3.83946378
10Hypoglycemic coma (HP:0001325)3.79800733
11Abnormality of the renal cortex (HP:0011035)3.79448034
12* Hyperammonemia (HP:0001987)3.75308185
13Intrahepatic cholestasis (HP:0001406)3.69139966
14Xanthomatosis (HP:0000991)3.60774363
15Hepatic necrosis (HP:0002605)3.48022507
16Intestinal atresia (HP:0011100)3.45842126
17Abnormality of fatty-acid metabolism (HP:0004359)3.43992785
18Deep venous thrombosis (HP:0002625)3.36459975
19Prolonged partial thromboplastin time (HP:0003645)3.36449599
20Medial flaring of the eyebrow (HP:0010747)3.34098417
21Sudden death (HP:0001699)3.33321673
22Cerebral edema (HP:0002181)3.29226472
23* Dicarboxylic aciduria (HP:0003215)3.21636212
24* Abnormality of dicarboxylic acid metabolism (HP:0010995)3.21636212
25Reduced antithrombin III activity (HP:0001976)3.17081999
26Gaze-evoked nystagmus (HP:0000640)3.16769960
27Acute encephalopathy (HP:0006846)3.08151711
28Exercise-induced myalgia (HP:0003738)3.06460006
29Hypobetalipoproteinemia (HP:0003563)3.06193141
30Hepatocellular necrosis (HP:0001404)3.04441361
31Proximal tubulopathy (HP:0000114)3.01127531
32* Metabolic acidosis (HP:0001942)2.94385330
33Fair hair (HP:0002286)2.91439935
34Congenital sensorineural hearing impairment (HP:0008527)2.91175429
35Generalized aminoaciduria (HP:0002909)2.86642160
36Abnormal mitochondria in muscle tissue (HP:0008316)2.86084557
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.85089113
38* Abnormality of serum amino acid levels (HP:0003112)2.83912417
39Myoglobinuria (HP:0002913)2.82705982
40* Lethargy (HP:0001254)2.82362991
41Acute necrotizing encephalopathy (HP:0006965)2.81756141
42Gait imbalance (HP:0002141)2.79776140
43Syncope (HP:0001279)2.78596784
44Congenital primary aphakia (HP:0007707)2.75527706
45Hypoalphalipoproteinemia (HP:0003233)2.74324346
46Palpitations (HP:0001962)2.72283964
47Hypolipoproteinemia (HP:0010981)2.71047942
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.67879533
49Muscle hypertrophy of the lower extremities (HP:0008968)2.66243395
50Nephrogenic diabetes insipidus (HP:0009806)2.64604363
51Hyperventilation (HP:0002883)2.59521731
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.59282365
53Gout (HP:0001997)2.58899218
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.56069677
55Calf muscle hypertrophy (HP:0008981)2.55112392
56Conjugated hyperbilirubinemia (HP:0002908)2.52134789
57Increased muscle lipid content (HP:0009058)2.50352433
58Ventricular fibrillation (HP:0001663)2.49847928
59Lactic acidosis (HP:0003128)2.49724695
60Steatorrhea (HP:0002570)2.49374343
61Mitochondrial inheritance (HP:0001427)2.47622806
62Right ventricular cardiomyopathy (HP:0011663)2.39120134
63Bundle branch block (HP:0011710)2.38335784
64Progressive inability to walk (HP:0002505)2.38219917
65* Vomiting (HP:0002013)2.37118747
66Increased CSF lactate (HP:0002490)2.36398582
67Pancreatic cysts (HP:0001737)2.36362113
68Atrial fibrillation (HP:0005110)2.35937412
69Progressive macrocephaly (HP:0004481)2.35611581
70Abnormality of methionine metabolism (HP:0010901)2.35549628
71Amyotrophic lateral sclerosis (HP:0007354)2.34592954
72Nephronophthisis (HP:0000090)2.34064603
73Complement deficiency (HP:0004431)2.31774858
74Azoospermia (HP:0000027)2.29841611
75Increased serum pyruvate (HP:0003542)2.29312544
76Abnormality of glycolysis (HP:0004366)2.29312544
77Delayed CNS myelination (HP:0002188)2.28656592
78Hyperinsulinemic hypoglycemia (HP:0000825)2.27965722
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.27512279
80Hypothermia (HP:0002045)2.26979141
81Abnormality of B cell number (HP:0010975)2.24414137
82Epidermoid cyst (HP:0200040)2.24022690
83Attenuation of retinal blood vessels (HP:0007843)2.22897095
84Abnormality of sulfur amino acid metabolism (HP:0004339)2.21988441
85Primary atrial arrhythmia (HP:0001692)2.21582342
86Increased intramyocellular lipid droplets (HP:0012240)2.20409181
87Molar tooth sign on MRI (HP:0002419)2.19992137
88Abnormality of midbrain morphology (HP:0002418)2.19992137
89Prolonged QT interval (HP:0001657)2.19941177
90Abnormality of alanine metabolism (HP:0010916)2.18240224
91Hyperalaninemia (HP:0003348)2.18240224
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18240224
93Abnormality of glutamine family amino acid metabolism (HP:0010902)2.17948071
94Abnormal social behavior (HP:0012433)2.17296944
95Impaired social interactions (HP:0000735)2.17296944
96Athetosis (HP:0002305)2.14574942
97* Methylmalonic aciduria (HP:0012120)2.14436976
98Heart block (HP:0012722)2.14282720
99Focal motor seizures (HP:0011153)2.14143903
100Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12604233
101Abnormality of polysaccharide metabolism (HP:0011012)2.12604233
102Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12604233
103Sensorimotor neuropathy (HP:0007141)2.12530993
104Hypoglycemic seizures (HP:0002173)2.12419392
105Abnormal protein glycosylation (HP:0012346)2.12379770
106Abnormal glycosylation (HP:0012345)2.12379770
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12379770
108Abnormal protein N-linked glycosylation (HP:0012347)2.12379770
109Broad-based gait (HP:0002136)2.11591482
110Abnormality of the renal medulla (HP:0100957)2.11340412
111Ventricular tachycardia (HP:0004756)2.10427136
112B lymphocytopenia (HP:0010976)2.10289568
113Ventricular arrhythmia (HP:0004308)2.09286497
114Fat malabsorption (HP:0002630)2.09248310
115Cholelithiasis (HP:0001081)2.08560128
116Atrioventricular block (HP:0001678)2.07904443
117Supraventricular tachycardia (HP:0004755)2.07761942
118Urinary glycosaminoglycan excretion (HP:0003541)2.07021095
119Mucopolysacchariduria (HP:0008155)2.07021095
120Generalized hypopigmentation of hair (HP:0011358)2.06570464
121Abnormal gallbladder morphology (HP:0012437)2.06224723
122Poor eye contact (HP:0000817)2.05759849
123Progressive cerebellar ataxia (HP:0002073)2.05733055
124Nausea (HP:0002018)2.05101245
125Abnormality of purine metabolism (HP:0004352)2.03980716
126Pancreatic fibrosis (HP:0100732)2.03962028
127Hyperglycemia (HP:0003074)2.03159449
128Rhabdomyolysis (HP:0003201)2.02701057
129Hyperbilirubinemia (HP:0002904)2.02612627
130Febrile seizures (HP:0002373)2.02257112
131Genital tract atresia (HP:0001827)2.02074470
132Inability to walk (HP:0002540)2.01520328
133Type II lissencephaly (HP:0007260)2.01179757
134Ragged-red muscle fibers (HP:0003200)2.00930869
135Supraventricular arrhythmia (HP:0005115)2.00236173
136Chronic hepatic failure (HP:0100626)1.99117176
137Stomatitis (HP:0010280)1.99045195
138* Abnormality of vitamin B metabolism (HP:0004340)1.98667646
139Myokymia (HP:0002411)1.98453938
140CNS demyelination (HP:0007305)1.98452644
141Abnormal EKG (HP:0003115)1.97821139
142Abnormality of urine glucose concentration (HP:0011016)1.97777212
143Glycosuria (HP:0003076)1.97777212
144Cholecystitis (HP:0001082)1.97268904
145Abnormal gallbladder physiology (HP:0012438)1.97268904
146Tachypnea (HP:0002789)1.96617561
147Spontaneous abortion (HP:0005268)1.96606859
148Lipid accumulation in hepatocytes (HP:0006561)1.94906775
149Thyroiditis (HP:0100646)1.94463582
150Tubulointerstitial nephritis (HP:0001970)1.91208493
151Poor coordination (HP:0002370)1.90401675
152Intellectual disability, progressive (HP:0006887)1.89760591
153Large for gestational age (HP:0001520)1.88888657
154Absent speech (HP:0001344)1.88833567
155Renal Fanconi syndrome (HP:0001994)1.88617637
156Abnormal spermatogenesis (HP:0008669)1.84080378
157Short tibia (HP:0005736)1.84067571
158Abnormality of lateral ventricle (HP:0030047)1.83776212
159Adactyly (HP:0009776)1.83192614
160Vaginal atresia (HP:0000148)1.81833170
161Drooling (HP:0002307)1.78290070
162Tubulointerstitial abnormality (HP:0001969)1.77519927
163Hemiparesis (HP:0001269)1.77032764
164True hermaphroditism (HP:0010459)1.76606812
165Protruding tongue (HP:0010808)1.75324591
166Pachygyria (HP:0001302)1.75079452
167Disproportionate short-trunk short stature (HP:0003521)1.74872312
168Agitation (HP:0000713)1.73527483
169Tented upper lip vermilion (HP:0010804)1.71715041
170* Abnormality of vitamin metabolism (HP:0100508)1.71221393
171Aplasia/Hypoplasia of the lens (HP:0008063)1.70846935
172Type I transferrin isoform profile (HP:0003642)1.70430625
173Dialeptic seizures (HP:0011146)1.69970780
174Abolished electroretinogram (ERG) (HP:0000550)1.69260823
175Decreased circulating renin level (HP:0003351)1.68916083
176Hypoplasia of the fovea (HP:0007750)1.66645511
177Aplasia/Hypoplasia of the fovea (HP:0008060)1.66645511
178Albinism (HP:0001022)1.66546441

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.23566615
2TXK2.88014687
3EPHA42.71610810
4MAP4K22.68957813
5PHKG12.61104877
6PHKG22.61104877
7MAP2K72.60219309
8INSRR2.58982966
9MAP3K42.49666731
10MAP2K42.49544907
11PINK12.35749367
12MAP4K12.17417539
13ADRBK22.11626765
14ZAK2.03583812
15NTRK32.02972926
16TAOK32.02667926
17IRAK11.97053315
18LMTK21.95747859
19ACVR1B1.94212519
20TLK11.89497095
21PIK3CG1.86032000
22PDK41.83668519
23PDK31.83668519
24DAPK21.77367875
25MARK11.76656764
26CASK1.74776153
27BMPR1B1.72083980
28PIK3CA1.66034059
29OXSR11.62890068
30OBSCN1.60414288
31CAMK1D1.58817617
32ARAF1.58300003
33EPHA31.57515579
34CAMKK21.46663973
35MYLK1.44249705
36CDK191.42508717
37TIE11.35111336
38NEK91.35026100
39WNK41.33898481
40ERBB31.32156116
41STK391.30982282
42EIF2AK31.27723608
43GRK11.25776196
44NME11.25148362
45CSNK1G11.24274802
46CSNK1G21.19487575
47MST41.19235714
48SGK2231.18191350
49SGK4941.18191350
50IRAK21.16859517
51TNIK1.16093913
52PRKAA21.14975580
53BCR1.14502037
54TTN1.14303317
55PAK31.13421974
56CAMK1G1.12173319
57PKN11.11108604
58CSNK1A1L1.10128871
59CSNK1G31.10048762
60STK38L1.08273120
61CAMK2D1.07612005
62CAMK2A1.04742149
63DYRK21.04555892
64MAP3K121.04218884
65SGK21.03127206
66CAMK11.01507412
67PRKD31.00546826
68STK381.00398073
69CAMK2B0.98052487
70PDK20.96844459
71MAPK130.96787000
72MUSK0.96682503
73MAP3K70.96249243
74VRK10.95583097
75WNK30.95191816
76MAPK120.94081413
77MINK10.93216455
78PIM20.88757421
79RPS6KA50.87801522
80GRK70.87605396
81PRKCG0.87591922
82GRK50.86995961
83MOS0.86527086
84NTRK20.85656846
85CDK50.84838026
86MST1R0.84669921
87PRKCH0.83599006
88CAMK40.83188528
89CAMK2G0.82830002
90MAPK110.82424079
91MAP3K90.81633036
92MAP2K60.80541800
93MAPK150.80452597
94FER0.78508112
95PRKCE0.76440697
96TRIM280.74726353
97BMPR20.73866859
98PDPK10.73155406
99FGFR40.72762606
100PRKD10.71662113
101TAOK10.70387704
102STK240.69964913
103CAMKK10.68790770
104PRKAA10.67792699
105FRK0.66560718
106MKNK20.66322667
107PDK10.64152299
108NUAK10.62936336
109PRKACA0.62711134
110PIM10.62348024
111IKBKB0.61539665
112PRKD20.61293947
113SGK30.61060269
114AKT30.60492789
115DAPK30.57837941
116PRKCQ0.56023326
117CDK30.55387199
118CHUK0.55290863
119PRKACG0.55133710
120CDC42BPA0.54885963
121NTRK10.54412239
122PRKCI0.53189169
123PTK2B0.52113128
124MAP3K130.52108767
125RIPK40.51638462
126YES10.51531375
127PRKACB0.51100679
128NEK10.49443919
129MARK20.48777292
130SGK10.48625390
131TNK20.47571856
132RET0.47343957
133PRKCZ0.46794372
134MARK30.46700756
135CSNK1D0.46231040
136ERBB40.46155674
137ABL10.46055929
138PRKG10.45437264
139MAP3K140.45098163
140IKBKE0.44844199
141FLT30.44043606
142MAP2K10.43663517
143STK110.43651202
144NLK0.42850017
145ZAP700.42234334
146STK160.41897860
147DAPK10.40867078
148SYK0.40457315
149RAF10.37273024
150MAP3K50.36690789
151ADRBK10.36126671
152LYN0.34294260
153CSNK1A10.33692831
154PLK20.30445283

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.04036689
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.80829071
3Propanoate metabolism_Homo sapiens_hsa006402.79262452
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.77405845
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.76670113
6Fatty acid degradation_Homo sapiens_hsa000712.65724613
7Butanoate metabolism_Homo sapiens_hsa006502.57832151
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.49212837
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.39838884
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.32846023
11Nitrogen metabolism_Homo sapiens_hsa009102.27730625
12Linoleic acid metabolism_Homo sapiens_hsa005912.26985202
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.26950153
14Fatty acid metabolism_Homo sapiens_hsa012122.15259673
15Tryptophan metabolism_Homo sapiens_hsa003802.14022408
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13207224
17Arginine biosynthesis_Homo sapiens_hsa002202.09458723
18Fatty acid elongation_Homo sapiens_hsa000621.95669643
19Basal transcription factors_Homo sapiens_hsa030221.79831606
20Peroxisome_Homo sapiens_hsa041461.76071009
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.74643877
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73373700
23beta-Alanine metabolism_Homo sapiens_hsa004101.72030355
24Pyruvate metabolism_Homo sapiens_hsa006201.70004724
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66288067
26PPAR signaling pathway_Homo sapiens_hsa033201.59691549
27Sulfur metabolism_Homo sapiens_hsa009201.56235849
28Circadian rhythm_Homo sapiens_hsa047101.54909893
29Oxidative phosphorylation_Homo sapiens_hsa001901.51291357
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49493473
31Regulation of autophagy_Homo sapiens_hsa041401.47381668
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47153420
33Carbon metabolism_Homo sapiens_hsa012001.45562888
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40521026
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38373468
36Histidine metabolism_Homo sapiens_hsa003401.38199969
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34591267
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.31317925
39Chemical carcinogenesis_Homo sapiens_hsa052041.29250308
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26108757
41Cardiac muscle contraction_Homo sapiens_hsa042601.24688973
42Ether lipid metabolism_Homo sapiens_hsa005651.24651441
43Dorso-ventral axis formation_Homo sapiens_hsa043201.23533080
44Parkinsons disease_Homo sapiens_hsa050121.23039484
45Phenylalanine metabolism_Homo sapiens_hsa003601.21964635
46Arachidonic acid metabolism_Homo sapiens_hsa005901.19406517
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.18892902
48Nicotine addiction_Homo sapiens_hsa050331.18387867
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17656153
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17425144
51Type I diabetes mellitus_Homo sapiens_hsa049401.13660359
52Complement and coagulation cascades_Homo sapiens_hsa046101.11974656
53Bile secretion_Homo sapiens_hsa049761.10279854
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07546340
55Alzheimers disease_Homo sapiens_hsa050101.04609606
56Vitamin B6 metabolism_Homo sapiens_hsa007501.03898816
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03370027
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02713391
59Tyrosine metabolism_Homo sapiens_hsa003501.02519042
60Drug metabolism - other enzymes_Homo sapiens_hsa009831.01188956
61Biosynthesis of amino acids_Homo sapiens_hsa012300.95674879
62GABAergic synapse_Homo sapiens_hsa047270.93403575
63Phototransduction_Homo sapiens_hsa047440.91919991
64Starch and sucrose metabolism_Homo sapiens_hsa005000.90882779
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.88490482
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.86471780
67Retinol metabolism_Homo sapiens_hsa008300.86244525
68Serotonergic synapse_Homo sapiens_hsa047260.85767565
69Protein export_Homo sapiens_hsa030600.85579622
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84249592
71Rheumatoid arthritis_Homo sapiens_hsa053230.82986494
72Arginine and proline metabolism_Homo sapiens_hsa003300.81709582
73Asthma_Homo sapiens_hsa053100.81130620
74Fat digestion and absorption_Homo sapiens_hsa049750.80749031
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80082732
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.79520070
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78606998
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78482031
79Mineral absorption_Homo sapiens_hsa049780.74293458
80Folate biosynthesis_Homo sapiens_hsa007900.73615086
81Morphine addiction_Homo sapiens_hsa050320.71943072
82Selenocompound metabolism_Homo sapiens_hsa004500.70793349
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68840529
84ABC transporters_Homo sapiens_hsa020100.68715162
85One carbon pool by folate_Homo sapiens_hsa006700.68421508
86Glycerolipid metabolism_Homo sapiens_hsa005610.67885945
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67850896
88Circadian entrainment_Homo sapiens_hsa047130.67656557
89Allograft rejection_Homo sapiens_hsa053300.66797467
90Huntingtons disease_Homo sapiens_hsa050160.65503206
91Fatty acid biosynthesis_Homo sapiens_hsa000610.64639898
92Taste transduction_Homo sapiens_hsa047420.63076596
93Synaptic vesicle cycle_Homo sapiens_hsa047210.61030281
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60193113
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59966450
96RNA degradation_Homo sapiens_hsa030180.58296125
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57952565
98Metabolic pathways_Homo sapiens_hsa011000.57648918
99Glutamatergic synapse_Homo sapiens_hsa047240.57188100
100Lysosome_Homo sapiens_hsa041420.56656328
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.56572333
102Vitamin digestion and absorption_Homo sapiens_hsa049770.56128120
103Autoimmune thyroid disease_Homo sapiens_hsa053200.55746844
104Insulin secretion_Homo sapiens_hsa049110.55344068
105Systemic lupus erythematosus_Homo sapiens_hsa053220.53902147
106Ovarian steroidogenesis_Homo sapiens_hsa049130.52923068
107Sphingolipid metabolism_Homo sapiens_hsa006000.52397409
108Lysine degradation_Homo sapiens_hsa003100.51102645
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50680121
110Olfactory transduction_Homo sapiens_hsa047400.47771465
111Calcium signaling pathway_Homo sapiens_hsa040200.47713316
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47551325
113Dilated cardiomyopathy_Homo sapiens_hsa054140.46524984
114Steroid biosynthesis_Homo sapiens_hsa001000.45925410
115Sulfur relay system_Homo sapiens_hsa041220.45572092
116Graft-versus-host disease_Homo sapiens_hsa053320.43891211
117Glucagon signaling pathway_Homo sapiens_hsa049220.43608785
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43078449
119Renin secretion_Homo sapiens_hsa049240.42950875
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42179126
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42034767
122Collecting duct acid secretion_Homo sapiens_hsa049660.42026321
123Amphetamine addiction_Homo sapiens_hsa050310.41654027
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39785469
125Salivary secretion_Homo sapiens_hsa049700.39607760
126Fructose and mannose metabolism_Homo sapiens_hsa000510.38148956
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34512514
128Pentose phosphate pathway_Homo sapiens_hsa000300.34496526
129Glutathione metabolism_Homo sapiens_hsa004800.32531219
130Dopaminergic synapse_Homo sapiens_hsa047280.32171482
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31242772
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.31000363
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30546672
134Type II diabetes mellitus_Homo sapiens_hsa049300.30299276
135NF-kappa B signaling pathway_Homo sapiens_hsa040640.29989189
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.29883708
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29540767
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29161748
139Staphylococcus aureus infection_Homo sapiens_hsa051500.28942659

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