MMADHC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial protein that is involved in an early step of vitamin B12 metabolism. Vitamin B12 (cobalamin) is essential for normal development and survival in humans. Mutations in this gene cause methylmalonic aciduria and homocystinuria type cblD (MMADHC), a disorder of cobalamin metabolism that is characterized by decreased levels of the coenzymes adenosylcobalamin and methylcobalamin. Pseudogenes have been identified on chromosomes 11 and X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)4.92216318
2ribosome assembly (GO:0042255)4.54906092
3establishment of integrated proviral latency (GO:0075713)4.36952940
4DNA double-strand break processing (GO:0000729)4.03100174
5purine nucleobase biosynthetic process (GO:0009113)3.90320715
6establishment of protein localization to mitochondrial membrane (GO:0090151)3.89417742
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.88979466
8L-phenylalanine metabolic process (GO:0006558)3.88979466
9IMP biosynthetic process (GO:0006188)3.88173408
10protein neddylation (GO:0045116)3.86530346
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.85134728
12ATP synthesis coupled proton transport (GO:0015986)3.85134728
13CENP-A containing nucleosome assembly (GO:0034080)3.84783782
14chromatin remodeling at centromere (GO:0031055)3.83015008
15L-phenylalanine catabolic process (GO:0006559)3.70894232
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.70894232
17lysine catabolic process (GO:0006554)3.59591443
18lysine metabolic process (GO:0006553)3.59591443
19glyoxylate metabolic process (GO:0046487)3.59272714
20ribonucleoprotein complex disassembly (GO:0032988)3.58227004
21organelle disassembly (GO:1903008)3.56761752
22chaperone-mediated protein transport (GO:0072321)3.51792154
23DNA damage response, detection of DNA damage (GO:0042769)3.51428105
24regulation of ubiquitin-protein transferase activity (GO:0051438)3.45936736
25nucleobase biosynthetic process (GO:0046112)3.45136719
26rRNA modification (GO:0000154)3.44307022
27establishment of viral latency (GO:0019043)3.44195913
28exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.43577394
29DNA replication checkpoint (GO:0000076)3.38424848
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38064814
31regulation of ligase activity (GO:0051340)3.35652463
32tRNA aminoacylation for protein translation (GO:0006418)3.34507576
33tricarboxylic acid cycle (GO:0006099)3.33939347
34regulation of mitotic spindle checkpoint (GO:1903504)3.32471524
35regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32471524
36tRNA aminoacylation (GO:0043039)3.32407217
37amino acid activation (GO:0043038)3.32407217
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.30708231
39respiratory chain complex IV assembly (GO:0008535)3.30069012
40DNA deamination (GO:0045006)3.29538471
41folic acid-containing compound biosynthetic process (GO:0009396)3.26145929
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.23108065
43termination of RNA polymerase III transcription (GO:0006386)3.23108065
44DNA catabolic process, exonucleolytic (GO:0000738)3.22490269
45DNA ligation (GO:0006266)3.21629376
46amino-acid betaine metabolic process (GO:0006577)3.19062238
47histone exchange (GO:0043486)3.18744662
48regulation of helicase activity (GO:0051095)3.17984379
49proteasome assembly (GO:0043248)3.17771705
50non-recombinational repair (GO:0000726)3.17167446
51double-strand break repair via nonhomologous end joining (GO:0006303)3.17167446
52cysteine metabolic process (GO:0006534)3.16798715
53mitotic metaphase plate congression (GO:0007080)3.15177231
54DNA replication-dependent nucleosome organization (GO:0034723)3.14796108
55DNA replication-dependent nucleosome assembly (GO:0006335)3.14796108
56fatty acid beta-oxidation (GO:0006635)3.14528780
57protein K11-linked ubiquitination (GO:0070979)3.14356814
58histone mRNA metabolic process (GO:0008334)3.12915594
59valine metabolic process (GO:0006573)3.11306445
60fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.11171912
61respiratory electron transport chain (GO:0022904)3.10002527
62negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09016171
63negative regulation of mitotic sister chromatid separation (GO:2000816)3.09016171
64negative regulation of sister chromatid segregation (GO:0033046)3.09016171
65negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09016171
66negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09016171
67mitotic spindle checkpoint (GO:0071174)3.08309477
68protein targeting to mitochondrion (GO:0006626)3.07005447
69DNA replication-independent nucleosome organization (GO:0034724)3.06352348
70DNA replication-independent nucleosome assembly (GO:0006336)3.06352348
71carnitine metabolic process (GO:0009437)3.05164270
72pteridine-containing compound biosynthetic process (GO:0042559)3.05162108
73glycine metabolic process (GO:0006544)3.04923608
74aldehyde catabolic process (GO:0046185)3.03491935
75pseudouridine synthesis (GO:0001522)3.03243810
76negative regulation of protein ubiquitination (GO:0031397)3.03077727
77electron transport chain (GO:0022900)3.02809225
78spindle checkpoint (GO:0031577)3.01309051
79aromatic amino acid family catabolic process (GO:0009074)3.01265907
80rRNA methylation (GO:0031167)3.00981859
81negative regulation of chromosome segregation (GO:0051985)2.99554070
82oxidative phosphorylation (GO:0006119)2.99353785
83protein localization to mitochondrion (GO:0070585)2.99157804
84mitochondrial respiratory chain complex assembly (GO:0033108)2.97737368
85L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97470327
86amino acid salvage (GO:0043102)2.96846341
87L-methionine salvage (GO:0071267)2.96846341
88L-methionine biosynthetic process (GO:0071265)2.96846341
89protein complex biogenesis (GO:0070271)2.96099955
90alpha-linolenic acid metabolic process (GO:0036109)2.95885074
91mitochondrial respiratory chain complex I assembly (GO:0032981)2.94061621
92NADH dehydrogenase complex assembly (GO:0010257)2.94061621
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94061621
94negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93994567
95metaphase plate congression (GO:0051310)2.93069128
96regulation of cellular amino acid metabolic process (GO:0006521)2.92741093
97serine family amino acid biosynthetic process (GO:0009070)2.91562985
98G1/S transition of mitotic cell cycle (GO:0000082)2.91492581
99cell cycle G1/S phase transition (GO:0044843)2.91492581
100branched-chain amino acid catabolic process (GO:0009083)2.91206554
101ribosomal large subunit biogenesis (GO:0042273)2.89184491
102spliceosomal snRNP assembly (GO:0000387)2.88328010
103mitotic spindle assembly checkpoint (GO:0007094)2.88090784
104water-soluble vitamin biosynthetic process (GO:0042364)2.87466769
105mitochondrial RNA metabolic process (GO:0000959)2.87368064
106bile acid biosynthetic process (GO:0006699)2.86830535
107inner mitochondrial membrane organization (GO:0007007)2.85897518
108coenzyme catabolic process (GO:0009109)2.84869015
109fatty acid oxidation (GO:0019395)2.80515252
110Golgi transport vesicle coating (GO:0048200)2.77883415
111COPI coating of Golgi vesicle (GO:0048205)2.77883415
112serine family amino acid metabolic process (GO:0009069)2.77386563
113fatty acid catabolic process (GO:0009062)2.76953904
114regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.75903129
1152-oxoglutarate metabolic process (GO:0006103)2.75813080
116positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75033286
117lipid oxidation (GO:0034440)2.74579650
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.73589540
119DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.70533833
120cofactor catabolic process (GO:0051187)2.69735371
121aspartate family amino acid catabolic process (GO:0009068)2.69416505
122protein deneddylation (GO:0000338)2.69140087
123branched-chain amino acid metabolic process (GO:0009081)2.68261085
124misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.68099412
125quinone biosynthetic process (GO:1901663)2.67813046
126ubiquinone biosynthetic process (GO:0006744)2.67813046
127tricarboxylic acid metabolic process (GO:0072350)2.66858376
128AMP metabolic process (GO:0046033)2.66677289
129sulfur amino acid catabolic process (GO:0000098)2.65848407
130intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.65652040
131signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.65652040
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.65009234
133purine nucleotide salvage (GO:0032261)2.63389852
134regulation of mitochondrial translation (GO:0070129)2.61690817
135signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.60748575
136signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.60748575
137signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.60748575
138aspartate family amino acid metabolic process (GO:0009066)2.60669227
139triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.60134523
140negative regulation of ligase activity (GO:0051352)2.59372383
141negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59372383
142negative regulation of fibrinolysis (GO:0051918)2.59159785
143sulfur amino acid biosynthetic process (GO:0000097)2.59028854
144signal peptide processing (GO:0006465)2.58842730
145antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.58294528
146peptidyl-glutamic acid carboxylation (GO:0017187)2.57735549
147protein carboxylation (GO:0018214)2.57735549
148tetrahydrofolate metabolic process (GO:0046653)2.56582832
149acetyl-CoA metabolic process (GO:0006084)2.56502577
150signal transduction involved in DNA damage checkpoint (GO:0072422)2.53112849
151signal transduction involved in DNA integrity checkpoint (GO:0072401)2.53112849
152cellular ketone body metabolic process (GO:0046950)2.53107819
153ubiquinone metabolic process (GO:0006743)2.52986452
154mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.52723698
155kynurenine metabolic process (GO:0070189)2.52402492
156formation of translation preinitiation complex (GO:0001731)2.52307152
157mitochondrial calcium ion transport (GO:0006851)2.51094558
158signal transduction involved in cell cycle checkpoint (GO:0072395)2.48480842
159monocarboxylic acid catabolic process (GO:0072329)2.47804920
160indole-containing compound catabolic process (GO:0042436)2.47528177
161indolalkylamine catabolic process (GO:0046218)2.47528177
162tryptophan catabolic process (GO:0006569)2.47528177
163regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.47066908
164positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.46814989
165one-carbon metabolic process (GO:0006730)2.45986911
166antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.45902992
167tryptophan metabolic process (GO:0006568)2.44743199
168negative regulation of fatty acid biosynthetic process (GO:0045717)2.43194852
169aromatic amino acid family metabolic process (GO:0009072)2.41589039
170S-adenosylmethionine metabolic process (GO:0046500)2.41356415
171serine family amino acid catabolic process (GO:0009071)2.40537945
172oxaloacetate metabolic process (GO:0006107)2.39558139
173positive regulation of ligase activity (GO:0051351)2.38968712
174IMP metabolic process (GO:0046040)2.38930246
175nucleoside salvage (GO:0043174)2.37855163

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.57804938
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.58577096
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.55323277
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.52608790
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.41410755
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.37446391
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90983851
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.85183380
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.81137521
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79340327
11E2F7_22180533_ChIP-Seq_HELA_Human2.74500495
12* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.71934636
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.64537315
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.55142149
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.48486317
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47276514
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43760034
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.31586321
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31083374
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30550158
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.25693446
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19663953
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14816473
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.13499043
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12592828
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07702678
27DCP1A_22483619_ChIP-Seq_HELA_Human2.01444945
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99691978
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98752873
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91701818
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91468335
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90861292
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.89041159
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88757962
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.84274506
36* VDR_23849224_ChIP-Seq_CD4+_Human1.84015018
37GABP_19822575_ChIP-Seq_HepG2_Human1.83955691
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78258997
39AR_21909140_ChIP-Seq_LNCAP_Human1.76591637
40XRN2_22483619_ChIP-Seq_HELA_Human1.75514990
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.74917407
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72582717
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72359907
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.71361781
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70890127
46EWS_26573619_Chip-Seq_HEK293_Human1.69545640
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69353601
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69076695
49ZNF274_21170338_ChIP-Seq_K562_Hela1.64799251
50FUS_26573619_Chip-Seq_HEK293_Human1.64671442
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64444438
52FOXP3_21729870_ChIP-Seq_TREG_Human1.52934562
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50072806
54ELK1_19687146_ChIP-ChIP_HELA_Human1.48576415
55MYC_18940864_ChIP-ChIP_HL60_Human1.46524596
56FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.44188818
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42207452
58IGF1R_20145208_ChIP-Seq_DFB_Human1.41448998
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40493473
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40163264
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39745215
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.38482280
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37780625
64CLOCK_20551151_ChIP-Seq_293T_Human1.37075699
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36604075
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35156138
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35022075
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34349537
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32207934
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.31688238
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28263831
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27183016
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26666051
74TTF2_22483619_ChIP-Seq_HELA_Human1.23972461
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22889914
76* VDR_22108803_ChIP-Seq_LS180_Human1.21257419
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20843637
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19046804
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18236451
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15593622
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14159407
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11552423
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11348400
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10894481
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10712737
86SOX2_16153702_ChIP-ChIP_HESCs_Human1.08814210
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08545561
88* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08236575
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05273535
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05056090
91FOXM1_23109430_ChIP-Seq_U2OS_Human1.04688815
92KDM5A_27292631_Chip-Seq_BREAST_Human1.04263896
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03042391
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02322657
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.01953321
96* P300_19829295_ChIP-Seq_ESCs_Human1.01504945
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.01303054
98TFEB_21752829_ChIP-Seq_HELA_Human1.00920922
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99795055
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99287719
101* ELK1_22589737_ChIP-Seq_MCF10A_Human0.99108023
102NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96527131
103EZH2_27294783_Chip-Seq_NPCs_Mouse0.95831656
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94909561
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94885389
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94341353
107TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94275485
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93017794
109SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92644154
110IRF1_19129219_ChIP-ChIP_H3396_Human0.92625045
111ZNF263_19887448_ChIP-Seq_K562_Human0.91701406
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.91318856
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90542310
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89297479
115GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89295541
116GATA1_22025678_ChIP-Seq_K562_Human0.88083879
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87412800
118NFE2_27457419_Chip-Seq_LIVER_Mouse0.87384175
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86618197
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85744037
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85540511
122SALL4_22934838_ChIP-ChIP_CD34+_Human0.85049447
123TAF15_26573619_Chip-Seq_HEK293_Human0.84291830
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83546329
125SOX17_20123909_ChIP-Seq_XEN_Mouse0.83254468
126* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82338248
127TP63_17297297_ChIP-ChIP_HaCaT_Human0.81539743
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81153396
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80742551
130POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79460632
131MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.79458351
132ATF3_27146783_Chip-Seq_COLON_Human0.79386845
133PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79151630
134NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79008590
135GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77651019
136CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.76888931
137CRX_20693478_ChIP-Seq_RETINA_Mouse0.75714490
138ELF5_23300383_ChIP-Seq_T47D_Human0.75023035

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.79646594
2MP0003806_abnormal_nucleotide_metabolis4.64298286
3MP0005360_urolithiasis3.74860594
4MP0005085_abnormal_gallbladder_physiolo3.29522297
5MP0003941_abnormal_skin_development3.23453833
6MP0005365_abnormal_bile_salt3.17446172
7MP0002102_abnormal_ear_morphology2.76949544
8MP0003646_muscle_fatigue2.67167354
9MP0001529_abnormal_vocalization2.63361206
10MP0008875_abnormal_xenobiotic_pharmacok2.63197220
11MP0003693_abnormal_embryo_hatching2.55310417
12MP0003786_premature_aging2.47000054
13MP0006036_abnormal_mitochondrial_physio2.41391866
14MP0003186_abnormal_redox_activity2.38526957
15MP0003195_calcinosis2.26126448
16MP0008877_abnormal_DNA_methylation2.22483581
17MP0005451_abnormal_body_composition2.21462913
18MP0003890_abnormal_embryonic-extraembry2.20255250
19MP0002837_dystrophic_cardiac_calcinosis2.08809034
20MP0004957_abnormal_blastocyst_morpholog1.86056500
21MP0001666_abnormal_nutrient_absorption1.85352177
22MP0005083_abnormal_biliary_tract1.83923350
23MP0006072_abnormal_retinal_apoptosis1.83618115
24MP0001188_hyperpigmentation1.76885277
25MP0003656_abnormal_erythrocyte_physiolo1.74024360
26MP0005332_abnormal_amino_acid1.71965774
27MP0009697_abnormal_copulation1.71082510
28MP0008057_abnormal_DNA_replication1.69181087
29MP0003252_abnormal_bile_duct1.62586163
30MP0010329_abnormal_lipoprotein_level1.58872705
31MP0003705_abnormal_hypodermis_morpholog1.58838802
32MP0005319_abnormal_enzyme/_coenzyme1.57678323
33MP0000749_muscle_degeneration1.55022434
34MP0006035_abnormal_mitochondrial_morpho1.52111451
35MP0003567_abnormal_fetal_cardiomyocyte1.50351345
36MP0009840_abnormal_foam_cell1.44180069
37MP0002234_abnormal_pharynx_morphology1.41438068
38MP0002938_white_spotting1.39380829
39MP0005367_renal/urinary_system_phenotyp1.35857009
40MP0000516_abnormal_urinary_system1.35857009
41MP0000609_abnormal_liver_physiology1.35826622
42MP0000750_abnormal_muscle_regeneration1.35245683
43MP0008995_early_reproductive_senescence1.33394103
44MP0003315_abnormal_perineum_morphology1.32717876
45MP0005670_abnormal_white_adipose1.31354306
46MP0003718_maternal_effect1.30833878
47MP0005330_cardiomyopathy1.29581294
48MP0003221_abnormal_cardiomyocyte_apopto1.27467395
49MP0010352_gastrointestinal_tract_polyps1.24900983
50MP0003077_abnormal_cell_cycle1.23913563
51MP0001293_anophthalmia1.23155668
52MP0001764_abnormal_homeostasis1.23052550
53MP0009643_abnormal_urine_homeostasis1.20214537
54MP0002269_muscular_atrophy1.20035990
55MP0001697_abnormal_embryo_size1.19668660
56MP0005408_hypopigmentation1.16794392
57MP0003937_abnormal_limbs/digits/tail_de1.15743132
58MP0005636_abnormal_mineral_homeostasis1.13533088
59MP0000350_abnormal_cell_proliferation1.13327359
60MP0004084_abnormal_cardiac_muscle1.13229563
61MP0002118_abnormal_lipid_homeostasis1.12063763
62MP0008007_abnormal_cellular_replicative1.11628752
63MP0002751_abnormal_autonomic_nervous1.10267669
64MP0005380_embryogenesis_phenotype1.10231651
65MP0001672_abnormal_embryogenesis/_devel1.10231651
66MP0005645_abnormal_hypothalamus_physiol1.10032047
67MP0005075_abnormal_melanosome_morpholog1.09825405
68MP0005220_abnormal_exocrine_pancreas1.09674956
69MP0008932_abnormal_embryonic_tissue1.07853801
70MP0006054_spinal_hemorrhage1.07763013
71MP0005584_abnormal_enzyme/coenzyme_acti1.07423816
72MP0008789_abnormal_olfactory_epithelium1.07386183
73MP0005266_abnormal_metabolism1.04776784
74MP0002084_abnormal_developmental_patter1.04543387
75MP0004036_abnormal_muscle_relaxation1.04163905
76MP0008438_abnormal_cutaneous_collagen1.04030100
77MP0003868_abnormal_feces_composition1.03850097
78MP0000598_abnormal_liver_morphology1.03579248
79MP0003123_paternal_imprinting1.03347621
80MP0000647_abnormal_sebaceous_gland1.01943786
81MP0002090_abnormal_vision1.00379356
82MP0001661_extended_life_span0.99923416
83MP0002233_abnormal_nose_morphology0.99913496
84MP0003119_abnormal_digestive_system0.99528529
85MP0001853_heart_inflammation0.99199087
86MP0002080_prenatal_lethality0.96613000
87MP0002085_abnormal_embryonic_tissue0.94775943
88MP0005253_abnormal_eye_physiology0.94692179
89MP0005275_abnormal_skin_tensile0.94119228
90MP0004215_abnormal_myocardial_fiber0.93953654
91MP0004147_increased_porphyrin_level0.91838926
92MP0010094_abnormal_chromosome_stability0.90638728
93MP0002138_abnormal_hepatobiliary_system0.89675464
94MP0000358_abnormal_cell_content/0.89646649
95MP0001730_embryonic_growth_arrest0.89521326
96MP0005187_abnormal_penis_morphology0.88677113
97MP0010030_abnormal_orbit_morphology0.87605522
98MP0004087_abnormal_muscle_fiber0.86906582
99MP0003984_embryonic_growth_retardation0.86347395
100MP0005084_abnormal_gallbladder_morpholo0.85343808
101MP0002088_abnormal_embryonic_growth/wei0.84942799
102MP0003880_abnormal_central_pattern0.84112044
103MP0009053_abnormal_anal_canal0.83613893
104MP0001542_abnormal_bone_strength0.83560439
105MP0002106_abnormal_muscle_physiology0.83534886
106MP0008775_abnormal_heart_ventricle0.83025464
107MP0002160_abnormal_reproductive_system0.82887127
108MP0000751_myopathy0.82128583
109MP0004019_abnormal_vitamin_homeostasis0.81869529
110MP0001929_abnormal_gametogenesis0.80170518
111MP0003191_abnormal_cellular_cholesterol0.79738350
112MP0004782_abnormal_surfactant_physiolog0.79344702
113MP0002971_abnormal_brown_adipose0.78861148
114MP0001286_abnormal_eye_development0.78088455
115MP0000313_abnormal_cell_death0.77833025
116MP0002060_abnormal_skin_morphology0.77722120
117MP0004130_abnormal_muscle_cell0.77607846
118MP0002736_abnormal_nociception_after0.77301972
119MP0009672_abnormal_birth_weight0.76127612
120MP0010386_abnormal_urinary_bladder0.74669148
121MP0002254_reproductive_system_inflammat0.74373884
122MP0002210_abnormal_sex_determination0.73556714
123MP0008469_abnormal_protein_level0.73515398
124MP0003011_delayed_dark_adaptation0.73028893
125MP0009763_increased_sensitivity_to0.72696236
126MP0003121_genomic_imprinting0.72090560
127MP0008260_abnormal_autophagy0.71840370
128MP0003111_abnormal_nucleus_morphology0.70246825
129MP0002396_abnormal_hematopoietic_system0.70011926
130MP0003755_abnormal_palate_morphology0.69982635
131MP0001145_abnormal_male_reproductive0.69901373
132MP0002822_catalepsy0.69641520
133MP0001984_abnormal_olfaction0.68823443
134MP0001544_abnormal_cardiovascular_syste0.68822967
135MP0005385_cardiovascular_system_phenoty0.68822967
136MP0000653_abnormal_sex_gland0.68789010
137MP0001756_abnormal_urination0.67789049
138MP0002282_abnormal_trachea_morphology0.67758603
139MP0004145_abnormal_muscle_electrophysio0.67275711
140MP0005620_abnormal_muscle_contractility0.67207081
141MP0004197_abnormal_fetal_growth/weight/0.66964185
142MP0003950_abnormal_plasma_membrane0.66794199
143MP0009703_decreased_birth_body0.66754948
144MP0005023_abnormal_wound_healing0.66738538
145MP0001243_abnormal_dermal_layer0.65832507
146MP0005376_homeostasis/metabolism_phenot0.65678699
147MP0008058_abnormal_DNA_repair0.65314568
148MP0005395_other_phenotype0.65237839
149MP0001299_abnormal_eye_distance/0.65036547
150MP0009764_decreased_sensitivity_to0.63883388
151MP0000343_altered_response_to0.63582257
152MP0000759_abnormal_skeletal_muscle0.62821637
153MP0002019_abnormal_tumor_incidence0.62673886
154MP0003787_abnormal_imprinting0.62227540
155MP0005666_abnormal_adipose_tissue0.62139177
156MP0001727_abnormal_embryo_implantation0.61942191
157MP0002086_abnormal_extraembryonic_tissu0.61870429
158MP0000372_irregular_coat_pigmentation0.61234017
159MP0002078_abnormal_glucose_homeostasis0.60939167
160MP0001119_abnormal_female_reproductive0.60786901
161MP0003436_decreased_susceptibility_to0.60570710
162MP0005369_muscle_phenotype0.59938396
163MP0002111_abnormal_tail_morphology0.58887825
164MP0008872_abnormal_physiological_respon0.57227858

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.52568678
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.41355051
3Increased hepatocellular lipid droplets (HP:0006565)4.35360652
4Hypobetalipoproteinemia (HP:0003563)3.95728611
5Hepatic necrosis (HP:0002605)3.85778828
6Abnormality of fatty-acid metabolism (HP:0004359)3.64077261
7Hyperammonemia (HP:0001987)3.42535307
8Generalized aminoaciduria (HP:0002909)3.39388776
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.35412632
10Intrahepatic cholestasis (HP:0001406)3.35124633
11Rhabdomyolysis (HP:0003201)3.34350372
12Increased serum pyruvate (HP:0003542)3.34081878
13Abnormality of glycolysis (HP:0004366)3.34081878
14* Abnormality of dicarboxylic acid metabolism (HP:0010995)3.30210575
15* Dicarboxylic aciduria (HP:0003215)3.30210575
16Ketosis (HP:0001946)3.23603725
17Acute encephalopathy (HP:0006846)3.21851524
18Renal Fanconi syndrome (HP:0001994)3.18447233
19Myoglobinuria (HP:0002913)3.17081708
20Cerebral edema (HP:0002181)3.15755521
21Hepatocellular necrosis (HP:0001404)3.08377187
22Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.08351367
23Multiple enchondromatosis (HP:0005701)3.02875416
24Deep venous thrombosis (HP:0002625)3.00636814
25Colon cancer (HP:0003003)2.98460334
26Acute necrotizing encephalopathy (HP:0006965)2.97274672
27Abnormal mitochondria in muscle tissue (HP:0008316)2.94375266
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.94204702
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.94204702
30Nausea (HP:0002018)2.92916775
31Abnormality of the labia minora (HP:0012880)2.88405391
32Hyperglycinuria (HP:0003108)2.78575769
33Xanthomatosis (HP:0000991)2.78091846
34Prolonged partial thromboplastin time (HP:0003645)2.77837137
35Lactic acidosis (HP:0003128)2.76714887
36Ketoacidosis (HP:0001993)2.73817291
37Hypolipoproteinemia (HP:0010981)2.73549037
38* Lethargy (HP:0001254)2.70951752
39Increased CSF lactate (HP:0002490)2.70335764
40Proximal tubulopathy (HP:0000114)2.61724992
41Abnormality of serine family amino acid metabolism (HP:0010894)2.60604441
42Abnormality of glycine metabolism (HP:0010895)2.60604441
43Mitochondrial inheritance (HP:0001427)2.60069737
443-Methylglutaconic aciduria (HP:0003535)2.59294030
45Hyperglycinemia (HP:0002154)2.54094284
46Fat malabsorption (HP:0002630)2.53917703
47Increased serum lactate (HP:0002151)2.51945637
48Abnormal lung lobation (HP:0002101)2.51491943
49Exertional dyspnea (HP:0002875)2.51051170
50Metabolic acidosis (HP:0001942)2.50425601
51Microretrognathia (HP:0000308)2.49362178
52* Abnormality of serum amino acid levels (HP:0003112)2.48546676
53Ependymoma (HP:0002888)2.48396401
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48384786
55Abnormality of alanine metabolism (HP:0010916)2.47102640
56Hyperalaninemia (HP:0003348)2.47102640
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47102640
58Malnutrition (HP:0004395)2.46786201
59Conjunctival hamartoma (HP:0100780)2.45964058
60Abnormal protein glycosylation (HP:0012346)2.45815379
61Abnormal glycosylation (HP:0012345)2.45815379
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.45815379
63Abnormal protein N-linked glycosylation (HP:0012347)2.45815379
64* Abnormality of aspartate family amino acid metabolism (HP:0010899)2.43112449
65Abnormal cartilage morphology (HP:0002763)2.42271040
66Hyperbilirubinemia (HP:0002904)2.41645443
67Abnormality of the intrinsic pathway (HP:0010989)2.41600960
68Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.41530770
69Reduced antithrombin III activity (HP:0001976)2.39223019
70Exercise-induced muscle cramps (HP:0003710)2.37287740
71Steatorrhea (HP:0002570)2.35766080
72* Abnormality of methionine metabolism (HP:0010901)2.35222751
73Increased muscle lipid content (HP:0009058)2.33959810
74Opisthotonus (HP:0002179)2.31794919
75Hyperlipoproteinemia (HP:0010980)2.30954499
76Muscle fiber inclusion bodies (HP:0100299)2.30084222
77Microvesicular hepatic steatosis (HP:0001414)2.29522625
78Birth length less than 3rd percentile (HP:0003561)2.28214266
79Abnormality of the anterior horn cell (HP:0006802)2.26049823
80Degeneration of anterior horn cells (HP:0002398)2.26049823
81Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.24154963
82Abnormality of the common coagulation pathway (HP:0010990)2.23974268
83Amniotic constriction ring (HP:0009775)2.23487163
84Abnormality of placental membranes (HP:0011409)2.23487163
85Glycosuria (HP:0003076)2.23060546
86Abnormality of urine glucose concentration (HP:0011016)2.23060546
87Progressive macrocephaly (HP:0004481)2.22751545
88Palpitations (HP:0001962)2.22423354
89Respiratory failure (HP:0002878)2.20897519
90Lipid accumulation in hepatocytes (HP:0006561)2.20709525
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20333382
92Neoplasm of the colon (HP:0100273)2.18964731
93Congenital, generalized hypertrichosis (HP:0004540)2.15419089
94Nemaline bodies (HP:0003798)2.15045190
95Abnormality of chromosome stability (HP:0003220)2.14189877
96Gout (HP:0001997)2.13954080
97Respiratory difficulties (HP:0002880)2.12715297
98Meckel diverticulum (HP:0002245)2.11851617
99Leukodystrophy (HP:0002415)2.10283664
100Late onset (HP:0003584)2.09963189
101Exercise intolerance (HP:0003546)2.08782834
102Oral leukoplakia (HP:0002745)2.08655871
103Vomiting (HP:0002013)2.08236076
104Spastic diplegia (HP:0001264)2.06612768
105Optic disc pallor (HP:0000543)2.04844772
106Chromsome breakage (HP:0040012)2.04513921
107Abnormality of glutamine family amino acid metabolism (HP:0010902)2.03994567
108Ragged-red muscle fibers (HP:0003200)2.03565383
109Poor head control (HP:0002421)2.02703463
110Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01905974
111Abnormality of purine metabolism (HP:0004352)2.01472894
112* Methylmalonic acidemia (HP:0002912)1.99864816
113Cerebral hypomyelination (HP:0006808)1.99809271
114Type I transferrin isoform profile (HP:0003642)1.99470802
115Hypoalphalipoproteinemia (HP:0003233)1.99363880
116Abnormality of the ileum (HP:0001549)1.98965005
117* Abnormality of sulfur amino acid metabolism (HP:0004339)1.98423914
118Abnormality of nucleobase metabolism (HP:0010932)1.97750316
119Aplasia/Hypoplasia of the uvula (HP:0010293)1.94795785
120Exercise-induced myalgia (HP:0003738)1.94053658
121Pancreatic islet-cell hyperplasia (HP:0004510)1.93506387
122Abnormality of the preputium (HP:0100587)1.92757132
123Hypoglycemic seizures (HP:0002173)1.92602228
124Increased intramyocellular lipid droplets (HP:0012240)1.91411477
125Gonadotropin excess (HP:0000837)1.90833048
126Hypothermia (HP:0002045)1.90671696
127Neoplasm of the adrenal gland (HP:0100631)1.90317028
128Abnormality of pyrimidine metabolism (HP:0004353)1.90305159
129CNS demyelination (HP:0007305)1.89548960
130Stenosis of the external auditory canal (HP:0000402)1.89483671
131Abnormality of renal resorption (HP:0011038)1.89024870
132Postnatal microcephaly (HP:0005484)1.88977858
133Medulloblastoma (HP:0002885)1.86192217
134Embryonal renal neoplasm (HP:0011794)1.84583738
135Nephroblastoma (Wilms tumor) (HP:0002667)1.83678033
136Rhabdomyosarcoma (HP:0002859)1.83674530
137Aplastic anemia (HP:0001915)1.81846105
138Medial flaring of the eyebrow (HP:0010747)1.81837998
139Small intestinal stenosis (HP:0012848)1.81722715
140Duodenal stenosis (HP:0100867)1.81722715
141Abnormality of transition element cation homeostasis (HP:0011030)1.81591172
142Delayed CNS myelination (HP:0002188)1.76947006
143Abnormal gallbladder morphology (HP:0012437)1.76871261
144Cholecystitis (HP:0001082)1.75034468
145Abnormal gallbladder physiology (HP:0012438)1.75034468
146Sparse eyelashes (HP:0000653)1.74880437
147Increased serum ferritin (HP:0003281)1.74345308
148Hyperinsulinemic hypoglycemia (HP:0000825)1.74148371
149Cholelithiasis (HP:0001081)1.73831968
150Median cleft lip (HP:0000161)1.73616247
151Bifid tongue (HP:0010297)1.72850285
152Secondary amenorrhea (HP:0000869)1.70868117
153Neoplasm of the small intestine (HP:0100833)1.69099299
154Shoulder girdle muscle weakness (HP:0003547)1.68856839
155Cortical dysplasia (HP:0002539)1.68347138

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.13187235
2NME23.54528616
3BUB13.08100591
4TRIM282.87004586
5TSSK62.68087486
6EIF2AK12.62918112
7PKN22.56993768
8VRK22.56993391
9STK162.52962777
10PDK42.36099443
11PDK32.36099443
12ERN12.23082679
13PBK2.13877668
14FLT32.12541665
15ACVR1B2.10715009
16MAP3K122.10279948
17NUAK11.98823478
18BCR1.97944238
19MAP4K21.93015985
20TESK11.92432880
21BRSK21.85765772
22OBSCN1.84006750
23WEE11.80868521
24NEK91.74660557
25EIF2AK31.72530540
26STK38L1.66373857
27TTN1.63647577
28NEK11.59680709
29ERBB31.54385689
30PLK41.53606947
31TESK21.50589912
32MAP3K31.47535757
33RPS6KA41.46001684
34MAP3K41.44712489
35ABL21.43619495
36MUSK1.43168659
37TGFBR11.41443426
38PIM21.39275645
39ERBB41.37614285
40CDC71.36260042
41TAF11.34286445
42MAPKAPK31.33296472
43BRAF1.31093318
44PIK3CG1.29389396
45KDR1.27408758
46LATS11.24604433
47MAP3K111.21936303
48TRIB31.21125307
49TNIK1.19604239
50LIMK11.18154004
51NEK21.17048498
52NME11.16596943
53MAP2K71.14398958
54MKNK11.14346113
55EIF2AK21.12000614
56CLK11.10103044
57MAP2K31.05466909
58AURKA1.02117609
59PDK21.00293290
60CSNK1G30.99549771
61CSNK1G10.98874987
62TTK0.98539863
63PASK0.94369340
64CSNK1G20.89382699
65MKNK20.87974519
66LATS20.87836065
67ARAF0.87806544
68MYLK0.85884283
69DYRK30.85147052
70PLK20.82981159
71RPS6KB20.81065324
72AURKB0.80640891
73CSNK1A1L0.80499903
74BRSK10.79588138
75BMPR1B0.79323589
76FRK0.79092282
77MAP3K80.76678123
78SRPK10.76431224
79SCYL20.75671360
80PLK10.74868563
81LRRK20.72410623
82TYK20.72225924
83GRK10.68410271
84DYRK1B0.68227177
85VRK10.66545135
86MAP3K50.65920838
87CHEK20.65499846
88NLK0.63912340
89STK30.63593172
90MOS0.63566348
91CDK80.62982435
92PAK40.60524120
93DYRK20.59487775
94ATM0.57789857
95STK100.56240976
96PIK3CA0.55557578
97OXSR10.54608575
98CCNB10.53911358
99STK240.53373252
100TBK10.52441930
101KSR20.52218353
102RAF10.51818892
103STK40.51246827
104MAPK130.50142483
105ILK0.49751544
106BMPR20.49602778
107CSNK2A20.48673933
108DAPK10.47659130
109ZAK0.47094946
110MAP2K10.46745205
111MST40.45788221
112MINK10.45742377
113SIK30.44969679
114IRAK30.44754102
115MET0.43107721
116CDK70.42921025
117CDK40.42515160
118CSNK2A10.42198451
119MAPK110.41815039
120MAPKAPK50.41715402
121RPS6KA50.41599499
122TRPM70.41398445
123WNK30.40513233
124PAK10.40417735
125ALK0.39959512
126TLK10.39591545
127FER0.39341961
128CHEK10.36974040
129FGFR10.36456052
130CSNK1E0.36420032
131TEC0.36288898
132STK390.36282481
133ATR0.36145466
134PRKCE0.35647679
135MST1R0.34250179
136WNK40.33802253
137ZAP700.33217489
138TGFBR20.30631375
139TAOK20.29155359
140PLK30.28477206
141PAK30.27867592
142CDK60.25478713
143CASK0.24011850
144INSRR0.23503813
145DAPK30.20871256

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030502.85088229
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.77543856
3Propanoate metabolism_Homo sapiens_hsa006402.47024110
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.38467730
5Fatty acid degradation_Homo sapiens_hsa000712.28821203
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26282006
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26077448
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.17865849
9Selenocompound metabolism_Homo sapiens_hsa004502.01495857
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.89540253
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88547058
12Carbon metabolism_Homo sapiens_hsa012001.88293616
13Protein export_Homo sapiens_hsa030601.86865134
14Folate biosynthesis_Homo sapiens_hsa007901.86758183
15Peroxisome_Homo sapiens_hsa041461.86613381
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80143707
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74676270
18Pyruvate metabolism_Homo sapiens_hsa006201.70723224
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.70280053
20DNA replication_Homo sapiens_hsa030301.69071869
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.66921669
22Tryptophan metabolism_Homo sapiens_hsa003801.60428163
23Fanconi anemia pathway_Homo sapiens_hsa034601.58066404
24Fatty acid metabolism_Homo sapiens_hsa012121.56867802
25Biosynthesis of amino acids_Homo sapiens_hsa012301.56584920
26Ribosome_Homo sapiens_hsa030101.54928074
27One carbon pool by folate_Homo sapiens_hsa006701.47311336
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46157418
29Oxidative phosphorylation_Homo sapiens_hsa001901.44393092
30Parkinsons disease_Homo sapiens_hsa050121.42037133
31Butanoate metabolism_Homo sapiens_hsa006501.39529076
32beta-Alanine metabolism_Homo sapiens_hsa004101.37654899
33Pyrimidine metabolism_Homo sapiens_hsa002401.36730453
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.35209149
35Sulfur relay system_Homo sapiens_hsa041221.34215321
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33775577
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33005911
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.32920462
39Fatty acid elongation_Homo sapiens_hsa000621.31032176
40Base excision repair_Homo sapiens_hsa034101.30330953
41Pentose phosphate pathway_Homo sapiens_hsa000301.26903498
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23755514
43Glutathione metabolism_Homo sapiens_hsa004801.21886417
44Arginine biosynthesis_Homo sapiens_hsa002201.17284774
45Sulfur metabolism_Homo sapiens_hsa009201.16517165
46RNA polymerase_Homo sapiens_hsa030201.15756879
47Chemical carcinogenesis_Homo sapiens_hsa052041.15533569
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14108649
49PPAR signaling pathway_Homo sapiens_hsa033201.13571644
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13483173
51Caffeine metabolism_Homo sapiens_hsa002321.11402298
52Complement and coagulation cascades_Homo sapiens_hsa046101.10600333
53Phenylalanine metabolism_Homo sapiens_hsa003601.08152400
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.07966520
55Mismatch repair_Homo sapiens_hsa034301.06526655
56Histidine metabolism_Homo sapiens_hsa003401.06174738
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05695783
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03880989
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02127340
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01962018
61Nucleotide excision repair_Homo sapiens_hsa034201.00776224
62Arginine and proline metabolism_Homo sapiens_hsa003301.00159524
63Fat digestion and absorption_Homo sapiens_hsa049750.95075916
64Huntingtons disease_Homo sapiens_hsa050160.94664846
65Tyrosine metabolism_Homo sapiens_hsa003500.94388175
66RNA transport_Homo sapiens_hsa030130.90675508
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90391975
68Retinol metabolism_Homo sapiens_hsa008300.86342757
69Nitrogen metabolism_Homo sapiens_hsa009100.86295052
70Homologous recombination_Homo sapiens_hsa034400.83742438
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83275896
72Starch and sucrose metabolism_Homo sapiens_hsa005000.82993152
73Fructose and mannose metabolism_Homo sapiens_hsa000510.82429710
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82309315
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81147290
76Spliceosome_Homo sapiens_hsa030400.81038656
77Cell cycle_Homo sapiens_hsa041100.80791224
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79501721
79Steroid biosynthesis_Homo sapiens_hsa001000.79410101
80Oocyte meiosis_Homo sapiens_hsa041140.78816977
81mRNA surveillance pathway_Homo sapiens_hsa030150.78223739
82Metabolic pathways_Homo sapiens_hsa011000.77677589
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.75732323
84Linoleic acid metabolism_Homo sapiens_hsa005910.72330717
85Cardiac muscle contraction_Homo sapiens_hsa042600.72328218
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71318524
87RNA degradation_Homo sapiens_hsa030180.70727127
88Alzheimers disease_Homo sapiens_hsa050100.69356778
89Legionellosis_Homo sapiens_hsa051340.66543385
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66300452
91p53 signaling pathway_Homo sapiens_hsa041150.64694258
92Basal transcription factors_Homo sapiens_hsa030220.63761558
93Vitamin B6 metabolism_Homo sapiens_hsa007500.62839448
94Purine metabolism_Homo sapiens_hsa002300.59861082
95Galactose metabolism_Homo sapiens_hsa000520.58876381
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52210338
97Phototransduction_Homo sapiens_hsa047440.46101481
98Collecting duct acid secretion_Homo sapiens_hsa049660.43410772
99Systemic lupus erythematosus_Homo sapiens_hsa053220.42902736
100Arachidonic acid metabolism_Homo sapiens_hsa005900.38259530
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35943671
102Glycerolipid metabolism_Homo sapiens_hsa005610.35539485
103N-Glycan biosynthesis_Homo sapiens_hsa005100.35414075
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.34044561
105Staphylococcus aureus infection_Homo sapiens_hsa051500.33358353
106Non-homologous end-joining_Homo sapiens_hsa034500.32015254
107Regulation of autophagy_Homo sapiens_hsa041400.31877834
108Epstein-Barr virus infection_Homo sapiens_hsa051690.29539894
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28248796
110ABC transporters_Homo sapiens_hsa020100.28154863
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26353355
112Vibrio cholerae infection_Homo sapiens_hsa051100.26106198
113TGF-beta signaling pathway_Homo sapiens_hsa043500.25921132
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23161319
115Thyroid cancer_Homo sapiens_hsa052160.21920203
116Alcoholism_Homo sapiens_hsa050340.20551532
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14167109
118Vitamin digestion and absorption_Homo sapiens_hsa049770.13713405

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