MMD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein is expressed by in vitro differentiated macrophages but not freshly isolated monocytes. Although sequence analysis identifies seven potential transmembrane domains, this protein has little homology to G-protein receptors and it has not been positively identified as a receptor. A suggested alternative function is that of an ion channel protein in maturing macrophages. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1blood coagulation, intrinsic pathway (GO:0007597)6.79143656
2negative regulation of norepinephrine secretion (GO:0010700)6.07016428
3low-density lipoprotein particle remodeling (GO:0034374)5.94808555
4thrombin receptor signaling pathway (GO:0070493)5.76593388
5protein neddylation (GO:0045116)5.72514660
6regulation of lipoprotein metabolic process (GO:0050746)5.21746170
7neutrophil activation involved in immune response (GO:0002283)4.81749309
8negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.80780291
9adenosine receptor signaling pathway (GO:0001973)4.62853024
10regulation of cAMP-dependent protein kinase activity (GO:2000479)4.56130253
11regulation of platelet activation (GO:0010543)4.55932478
12leukocyte migration involved in inflammatory response (GO:0002523)4.51335395
13regulation of platelet aggregation (GO:0090330)4.48918002
14positive regulation of endothelial cell differentiation (GO:0045603)4.40708212
15alpha-linolenic acid metabolic process (GO:0036109)4.36466944
16neutral lipid catabolic process (GO:0046461)4.36144357
17acylglycerol catabolic process (GO:0046464)4.36144357
18low-density lipoprotein particle clearance (GO:0034383)4.33707769
19positive regulation of hemostasis (GO:1900048)4.33258475
20positive regulation of blood coagulation (GO:0030194)4.33258475
21regulation of macrophage derived foam cell differentiation (GO:0010743)4.28222457
22triglyceride catabolic process (GO:0019433)4.27232157
23platelet aggregation (GO:0070527)4.26850463
24negative regulation of catecholamine secretion (GO:0033604)4.26493403
25regulation of norepinephrine secretion (GO:0014061)4.25398828
26negative regulation of platelet activation (GO:0010544)4.24057311
27platelet degranulation (GO:0002576)4.19213482
28angiogenesis involved in wound healing (GO:0060055)4.11990436
29regulation of Golgi to plasma membrane protein transport (GO:0042996)4.07289128
30regulation of integrin-mediated signaling pathway (GO:2001044)4.05205873
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.96446936
32reverse cholesterol transport (GO:0043691)3.93745736
33negative regulation of homotypic cell-cell adhesion (GO:0034111)3.92516398
34positive regulation of coagulation (GO:0050820)3.90363442
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.86639475
36L-phenylalanine catabolic process (GO:0006559)3.86639475
37positive regulation of fatty acid beta-oxidation (GO:0032000)3.82934806
38positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.82672335
39regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.80809713
40negative regulation of appetite (GO:0032099)3.77797181
41negative regulation of response to food (GO:0032096)3.77797181
42phospholipid homeostasis (GO:0055091)3.74738674
43regulation of sequestering of triglyceride (GO:0010889)3.67789031
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.63592874
45L-phenylalanine metabolic process (GO:0006558)3.63592874
46fatty acid elongation (GO:0030497)3.61148478
47fatty acid transmembrane transport (GO:1902001)3.59533448
48positive regulation of mast cell activation (GO:0033005)3.57721300
49positive regulation of fatty acid oxidation (GO:0046321)3.57623781
50negative regulation of protein localization to cell surface (GO:2000009)3.56594003
51plasma lipoprotein particle clearance (GO:0034381)3.53155720
52platelet activation (GO:0030168)3.51462685
53positive regulation of lipid catabolic process (GO:0050996)3.49684254
54complement activation, alternative pathway (GO:0006957)3.49555158
55cellular response to prostaglandin stimulus (GO:0071379)3.48552652
56negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.48206962
57negative regulation of thymocyte apoptotic process (GO:0070244)3.39861525
58regulation of cholesterol esterification (GO:0010872)3.39572763
59negative regulation of amine transport (GO:0051953)3.34220137
60regulation of triglyceride catabolic process (GO:0010896)3.33681111
61sulfur amino acid catabolic process (GO:0000098)3.25959318
62triglyceride homeostasis (GO:0070328)3.24428495
63acylglycerol homeostasis (GO:0055090)3.24428495
64glycerolipid catabolic process (GO:0046503)3.24373671
65response to dietary excess (GO:0002021)3.23870215
66positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.23734423
67regulation of fatty acid beta-oxidation (GO:0031998)3.19625567
68locomotory exploration behavior (GO:0035641)3.18071373
69aromatic amino acid family catabolic process (GO:0009074)3.17618273
70positive regulation of cAMP-mediated signaling (GO:0043950)3.17459391
71bile acid biosynthetic process (GO:0006699)3.17317197
72long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.17076302
73positive regulation of systemic arterial blood pressure (GO:0003084)3.14778145
74alanine transport (GO:0032328)3.14222083
75fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.12594386
76carnitine shuttle (GO:0006853)3.11621114
77regulation of short-term neuronal synaptic plasticity (GO:0048172)3.11529892
78vocalization behavior (GO:0071625)3.11169181
79fatty acid beta-oxidation (GO:0006635)3.11022531
80acetyl-CoA metabolic process (GO:0006084)3.09709049
81negative regulation of heart rate (GO:0010459)3.08451611
82urea metabolic process (GO:0019627)3.06525040
83urea cycle (GO:0000050)3.06525040
84biotin metabolic process (GO:0006768)3.02501301
85cellular ketone body metabolic process (GO:0046950)3.01080221
86proline transport (GO:0015824)3.00915884
87regulation of endothelial cell differentiation (GO:0045601)2.98610428
88negative regulation of lipase activity (GO:0060192)2.96820359
89plasma lipoprotein particle organization (GO:0071827)2.96103303
90synaptic vesicle maturation (GO:0016188)2.95645770
91nucleobase catabolic process (GO:0046113)2.94890103
92negative regulation of hemostasis (GO:1900047)2.94664998
93negative regulation of blood coagulation (GO:0030195)2.94664998
94fatty acid oxidation (GO:0019395)2.94372539
95polyamine biosynthetic process (GO:0006596)2.93729668
96regulation of blood coagulation (GO:0030193)2.93718159
97regulation of hemostasis (GO:1900046)2.93718159
98positive regulation of insulin receptor signaling pathway (GO:0046628)2.93140513
99valine metabolic process (GO:0006573)2.92418877
100regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.92237270
101positive regulation of receptor recycling (GO:0001921)2.91320271
102glutamate secretion (GO:0014047)2.91124969
103negative regulation of fibrinolysis (GO:0051918)2.90660827
104fatty acid catabolic process (GO:0009062)2.89561078
105lipoxygenase pathway (GO:0019372)2.89397715
106regulation of glutamate receptor signaling pathway (GO:1900449)2.89143775
107lipid oxidation (GO:0034440)2.89138386
108fibrinolysis (GO:0042730)2.88888813
109regulation of protein activation cascade (GO:2000257)2.88809443
110triglyceride biosynthetic process (GO:0019432)2.88469329
111bile acid metabolic process (GO:0008206)2.87955972
112triglyceride metabolic process (GO:0006641)2.85825775
113activation of protein kinase A activity (GO:0034199)2.85775908
114lysine catabolic process (GO:0006554)2.85541863
115lysine metabolic process (GO:0006553)2.85541863
116positive regulation of fatty acid metabolic process (GO:0045923)2.84888288
117regulation of fatty acid oxidation (GO:0046320)2.84747498
118dicarboxylic acid biosynthetic process (GO:0043650)2.84699313
119homotypic cell-cell adhesion (GO:0034109)2.84578537
120positive regulation of muscle hypertrophy (GO:0014742)2.84172680
121positive regulation of cardiac muscle hypertrophy (GO:0010613)2.84172680
122endothelium development (GO:0003158)2.83908109
123diacylglycerol metabolic process (GO:0046339)2.83447563
124high-density lipoprotein particle remodeling (GO:0034375)2.81192625
125neutral lipid biosynthetic process (GO:0046460)2.80958394
126acylglycerol biosynthetic process (GO:0046463)2.80958394
127fusion of sperm to egg plasma membrane (GO:0007342)2.79387686
128nitrogen cycle metabolic process (GO:0071941)2.79221898
129neutral lipid metabolic process (GO:0006638)2.79154043
130neurotransmitter-gated ion channel clustering (GO:0072578)2.78932673
131fatty acid homeostasis (GO:0055089)2.78895754
132regulation of fibrinolysis (GO:0051917)2.78306909
133protein-lipid complex subunit organization (GO:0071825)2.78278607
134brown fat cell differentiation (GO:0050873)2.77810613
135negative regulation of amino acid transport (GO:0051956)2.77573677
136G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.77212465
137acylglycerol metabolic process (GO:0006639)2.77057559
138kynurenine metabolic process (GO:0070189)2.76065188
139synaptic vesicle docking involved in exocytosis (GO:0016081)2.75918164
140regulation of complement activation (GO:0030449)2.75894014
141positive regulation of wound healing (GO:0090303)2.75657346
142cysteine metabolic process (GO:0006534)2.75492163
143positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.75135186
144regulation of cholesterol efflux (GO:0010874)2.74152992
145positive regulation of Rho protein signal transduction (GO:0035025)2.71879076
146short-chain fatty acid metabolic process (GO:0046459)2.71257245
147monocarboxylic acid catabolic process (GO:0072329)2.71202755
148synaptic vesicle exocytosis (GO:0016079)2.70814948
149negative regulation of protein localization to plasma membrane (GO:1903077)2.70738524
150fatty-acyl-CoA biosynthetic process (GO:0046949)2.70734027
151megakaryocyte development (GO:0035855)2.70545597
1522-oxoglutarate metabolic process (GO:0006103)2.70492738
153regulation of long-term neuronal synaptic plasticity (GO:0048169)2.69923288
154thioester biosynthetic process (GO:0035384)2.69304596
155acyl-CoA biosynthetic process (GO:0071616)2.69304596
156glutamate metabolic process (GO:0006536)2.68931621
157response to prostaglandin E (GO:0034695)2.67795040
158mesodermal cell differentiation (GO:0048333)2.67633389
159regulation of coagulation (GO:0050818)2.67415866
160ionotropic glutamate receptor signaling pathway (GO:0035235)2.66457801
161regulation of cholesterol storage (GO:0010885)2.65656452
162negative regulation of coagulation (GO:0050819)2.65367344
163epoxygenase P450 pathway (GO:0019373)2.65101437
164exploration behavior (GO:0035640)2.64037950
165fatty-acyl-CoA metabolic process (GO:0035337)2.63845481
166regulation of lipid catabolic process (GO:0050994)2.63711724
167protein carboxylation (GO:0018214)2.63532647
168peptidyl-glutamic acid carboxylation (GO:0017187)2.63532647
169white fat cell differentiation (GO:0050872)2.63136586
170beta-amyloid metabolic process (GO:0050435)2.63111173
171plasma lipoprotein particle remodeling (GO:0034369)2.61737359
172protein-lipid complex remodeling (GO:0034368)2.61737359
173macromolecular complex remodeling (GO:0034367)2.61737359
174neutrophil activation (GO:0042119)2.60735910
175amino-acid betaine metabolic process (GO:0006577)2.60385262
176long-chain fatty acid biosynthetic process (GO:0042759)2.60121868
177pyrimidine nucleobase catabolic process (GO:0006208)2.59748701
178negative regulation of heart contraction (GO:0045822)2.55095721

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.82560281
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.56031621
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.73476277
4* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.55697308
5EZH2_22144423_ChIP-Seq_EOC_Human3.55095023
6* RXR_22158963_ChIP-Seq_LIVER_Mouse3.43563650
7* LXR_22158963_ChIP-Seq_LIVER_Mouse2.87552310
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.72613079
9* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.48070993
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.46383449
11GBX2_23144817_ChIP-Seq_PC3_Human2.41855694
12SCL_19346495_ChIP-Seq_HPC-7_Human2.39924656
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37103509
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33762741
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33686799
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.30927244
17GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.29333068
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.25586518
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24858038
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22147073
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17174755
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17174755
23* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02935864
24JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02385295
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00750504
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99510001
27GATA1_19941826_ChIP-Seq_K562_Human1.94326344
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91225895
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91224389
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88485991
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.86160316
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.85985302
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.84167920
34CLOCK_20551151_ChIP-Seq_293T_Human1.83922140
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82017378
36* GATA2_19941826_ChIP-Seq_K562_Human1.80473884
37DROSHA_22980978_ChIP-Seq_HELA_Human1.79859242
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75984142
39TCF4_18268006_ChIP-ChIP_LS174T_Human1.74505443
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.74148711
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72573165
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72143591
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.67761733
44REST_21632747_ChIP-Seq_MESCs_Mouse1.66425259
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.64550900
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.63930245
47* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54452176
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52413574
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.50064498
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.49227807
51* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48409822
52SALL4_18804426_ChIP-ChIP_XEN_Mouse1.47209904
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46629920
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.46387092
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45610743
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.44827754
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44101383
58AR_21572438_ChIP-Seq_LNCaP_Human1.41575872
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.41141688
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.38284589
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38022883
62TAF15_26573619_Chip-Seq_HEK293_Human1.33222813
63HTT_18923047_ChIP-ChIP_STHdh_Human1.30890419
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29732954
65* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29208292
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27871129
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26734640
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25906911
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25785863
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25299812
71RNF2_27304074_Chip-Seq_NSC_Mouse1.24696137
72SPI1_23127762_ChIP-Seq_K562_Human1.24039027
73* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24014190
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.23114086
75GATA1_19941827_ChIP-Seq_MEL86_Mouse1.22758083
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20247656
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19900891
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19492713
79KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19475289
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18010109
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17779667
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17357131
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17248335
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15625010
85LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15510658
86* FOXO3_23340844_ChIP-Seq_DLD1_Human1.14365672
87BCAT_22108803_ChIP-Seq_LS180_Human1.14188450
88* SMAD4_21799915_ChIP-Seq_A2780_Human1.14165476
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13353706
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11588408
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11059821
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.10220672
93* FOXA2_19822575_ChIP-Seq_HepG2_Human1.09479616
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09104212
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08755514
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.08524232
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08447854
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08397742
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07499750
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06699584
101* AR_25329375_ChIP-Seq_VCAP_Human1.06158621
102* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05840820
103* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05554144
104ZNF263_19887448_ChIP-Seq_K562_Human1.05320671
105* PIAS1_25552417_ChIP-Seq_VCAP_Human1.05062135
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04060591
107* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04058522
108* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04058522
109P53_22387025_ChIP-Seq_ESCs_Mouse1.03806898
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.03529183
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02833584
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.02381904
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02152590
114RXR_22108803_ChIP-Seq_LS180_Human1.02044425
115* IRF8_27001747_Chip-Seq_BMDM_Mouse1.01647180
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01009008
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00085413
118* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99785073
119SALL4_22934838_ChIP-ChIP_CD34+_Human0.99445134
120SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98844346
121* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98825142
122DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98683464
123P300_19829295_ChIP-Seq_ESCs_Human0.97753239
124TP53_16413492_ChIP-PET_HCT116_Human0.97646866
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97411499
126IGF1R_20145208_ChIP-Seq_DFB_Human0.96471677
127GF1_26923725_Chip-Seq_HPCs_Mouse0.96166510
128EZH2_27294783_Chip-Seq_NPCs_Mouse0.95660517
129EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95626371
130* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94818612
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.94518752
132* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94401133
133E2F1_18555785_Chip-Seq_ESCs_Mouse0.94332948
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93438831
135PU1_27457419_Chip-Seq_LIVER_Mouse0.93363272
136SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92883168
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.92406864
138RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91511554
139KDM2B_26808549_Chip-Seq_K562_Human0.91335667
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.90970349
141AR_19668381_ChIP-Seq_PC3_Human0.90800899
142TP53_18474530_ChIP-ChIP_U2OS_Human0.90495802
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90232730
144ZNF274_21170338_ChIP-Seq_K562_Hela0.90191900
145CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90024029
146* SOX2_20726797_ChIP-Seq_SW620_Human0.89609548
147PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88878842
148SMAD3_21741376_ChIP-Seq_EPCs_Human0.88692007
149SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88566074
150CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88428812
151TAL1_26923725_Chip-Seq_HPCs_Mouse0.88387373
152PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88132961
153RING1B_27294783_Chip-Seq_ESCs_Mouse0.87978958
154NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87663254
155* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87299543
156SMAD4_21741376_ChIP-Seq_HESCs_Human0.86382942
157UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85770737
158AHR_22903824_ChIP-Seq_MCF-7_Human0.84675313
159STAT3_23295773_ChIP-Seq_U87_Human0.83968854
160ARNT_22903824_ChIP-Seq_MCF-7_Human0.83612065
161ESR2_21235772_ChIP-Seq_MCF-7_Human0.83457824
162TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79901147
163* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78684488
164SMAD3_21741376_ChIP-Seq_HESCs_Human0.77709238
165CBP_20019798_ChIP-Seq_JUKART_Human0.77555744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.25452812
2MP0008004_abnormal_stomach_pH4.58443610
3MP0004859_abnormal_synaptic_plasticity4.39314541
4MP0002139_abnormal_hepatobiliary_system4.28082972
5MP0005360_urolithiasis3.91483162
6MP0003724_increased_susceptibility_to3.60804036
7MP0005670_abnormal_white_adipose3.47166159
8MP0005365_abnormal_bile_salt3.45261265
9MP0003122_maternal_imprinting3.43071412
10MP0010329_abnormal_lipoprotein_level3.24327239
11MP0005085_abnormal_gallbladder_physiolo3.11304217
12MP0004130_abnormal_muscle_cell3.04643785
13MP0003880_abnormal_central_pattern2.83050886
14MP0000465_gastrointestinal_hemorrhage2.80543818
15MP0008875_abnormal_xenobiotic_pharmacok2.62303749
16MP0002837_dystrophic_cardiac_calcinosis2.56859252
17MP0005084_abnormal_gallbladder_morpholo2.52472565
18MP0003635_abnormal_synaptic_transmissio2.49879241
19MP0004510_myositis2.49453859
20MP0005666_abnormal_adipose_tissue2.45204935
21MP0002876_abnormal_thyroid_physiology2.28209577
22MP0001501_abnormal_sleep_pattern2.23664409
23MP0002063_abnormal_learning/memory/cond2.11008999
24MP0002822_catalepsy2.06751657
25MP0000013_abnormal_adipose_tissue2.05687278
26MP0009745_abnormal_behavioral_response2.00819132
27MP0003566_abnormal_cell_adhesion2.00741969
28MP0004185_abnormal_adipocyte_glucose2.00193755
29MP0000343_altered_response_to2.00088248
30MP0009780_abnormal_chondrocyte_physiolo1.99644216
31MP0002118_abnormal_lipid_homeostasis1.99641899
32MP0003329_amyloid_beta_deposits1.99521107
33MP0004270_analgesia1.99220504
34MP0003191_abnormal_cellular_cholesterol1.96412172
35MP0005535_abnormal_body_temperature1.91947301
36MP0005375_adipose_tissue_phenotype1.87170244
37MP0002909_abnormal_adrenal_gland1.86795502
38MP0003303_peritoneal_inflammation1.85886092
39MP0006054_spinal_hemorrhage1.83619517
40MP0003828_pulmonary_edema1.77288537
41MP0003252_abnormal_bile_duct1.76289442
42MP0002971_abnormal_brown_adipose1.73802941
43MP0005058_abnormal_lysosome_morphology1.69702448
44MP0002064_seizures1.67234350
45MP0001879_abnormal_lymphatic_vessel1.65199392
46MP0000604_amyloidosis1.55028616
47MP0005332_abnormal_amino_acid1.54976455
48MP0002572_abnormal_emotion/affect_behav1.54917404
49MP0003690_abnormal_glial_cell1.51551036
50MP0003011_delayed_dark_adaptation1.51467613
51MP0005409_darkened_coat_color1.50746446
52MP0008775_abnormal_heart_ventricle1.49380850
53MP0002638_abnormal_pupillary_reflex1.49303742
54MP0005334_abnormal_fat_pad1.47497174
55MP0004084_abnormal_cardiac_muscle1.41984269
56MP0001968_abnormal_touch/_nociception1.40262930
57MP0000003_abnormal_adipose_tissue1.39379828
58MP0003705_abnormal_hypodermis_morpholog1.36714766
59MP0005646_abnormal_pituitary_gland1.35955876
60MP0000609_abnormal_liver_physiology1.35519937
61MP0001486_abnormal_startle_reflex1.31486956
62MP0003123_paternal_imprinting1.30000761
63MP0005584_abnormal_enzyme/coenzyme_acti1.29612554
64MP0003638_abnormal_response/metabolism_1.27645631
65MP0001851_eye_inflammation1.26325108
66MP0000249_abnormal_blood_vessel1.24562015
67MP0001440_abnormal_grooming_behavior1.23506633
68MP0002272_abnormal_nervous_system1.21895510
69MP0008438_abnormal_cutaneous_collagen1.21325690
70MP0005448_abnormal_energy_balance1.21226623
71MP0009115_abnormal_fat_cell1.20891661
72MP0003075_altered_response_to1.16818462
73MP0009046_muscle_twitch1.15076593
74MP0005410_abnormal_fertilization1.14734800
75MP0002736_abnormal_nociception_after1.13868510
76MP0000858_altered_metastatic_potential1.13332484
77MP0003121_genomic_imprinting1.12124171
78MP0006276_abnormal_autonomic_nervous1.11108834
79MP0002078_abnormal_glucose_homeostasis1.09771826
80MP0003633_abnormal_nervous_system1.06702039
81MP0005386_behavior/neurological_phenoty1.06611604
82MP0004924_abnormal_behavior1.06611604
83MP0005319_abnormal_enzyme/_coenzyme1.04896013
84MP0008874_decreased_physiological_sensi1.03518276
85MP0004858_abnormal_nervous_system1.03492605
86MP0002734_abnormal_mechanical_nocicepti1.03242025
87MP0002733_abnormal_thermal_nociception1.01657499
88MP0010234_abnormal_vibrissa_follicle0.98428885
89MP0008872_abnormal_physiological_respon0.98238960
90MP0009840_abnormal_foam_cell0.97767350
91MP0001666_abnormal_nutrient_absorption0.97304450
92MP0002254_reproductive_system_inflammat0.97005273
93MP0001915_intracranial_hemorrhage0.96624922
94MP0002970_abnormal_white_adipose0.95540657
95MP0009763_increased_sensitivity_to0.95306165
96MP0005167_abnormal_blood-brain_barrier0.94762469
97MP0000751_myopathy0.94360364
98MP0003656_abnormal_erythrocyte_physiolo0.93443850
99MP0003959_abnormal_lean_body0.93158913
100MP0009642_abnormal_blood_homeostasis0.93041709
101MP0001544_abnormal_cardiovascular_syste0.91933208
102MP0005385_cardiovascular_system_phenoty0.91933208
103MP0008961_abnormal_basal_metabolism0.91279428
104MP0005187_abnormal_penis_morphology0.89855428
105MP0003195_calcinosis0.89725141
106MP0001177_atelectasis0.88957274
107MP0004019_abnormal_vitamin_homeostasis0.88926443
108MP0002069_abnormal_eating/drinking_beha0.88820960
109MP0010368_abnormal_lymphatic_system0.88583593
110MP0002090_abnormal_vision0.88008400
111MP0004272_abnormal_basement_membrane0.86859565
112MP0002132_abnormal_respiratory_system0.85587922
113MP0002128_abnormal_blood_circulation0.85057872
114MP0001764_abnormal_homeostasis0.84013593
115MP0005083_abnormal_biliary_tract0.84005424
116MP0001970_abnormal_pain_threshold0.79853044
117MP0005452_abnormal_adipose_tissue0.79535765
118MP0002067_abnormal_sensory_capabilities0.79208098
119MP0004811_abnormal_neuron_physiology0.79189558
120MP0003879_abnormal_hair_cell0.79172694
121MP0004484_altered_response_of0.78644316
122MP0004883_abnormal_blood_vessel0.77711261
123MP0004215_abnormal_myocardial_fiber0.76856905
124MP0005275_abnormal_skin_tensile0.76338727
125MP0003631_nervous_system_phenotype0.75276050
126MP0005595_abnormal_vascular_smooth0.75136835
127MP0000639_abnormal_adrenal_gland0.75132515
128MP0005423_abnormal_somatic_nervous0.74462533
129MP0002066_abnormal_motor_capabilities/c0.74175141
130MP0001661_extended_life_span0.74081685
131MP0005620_abnormal_muscle_contractility0.73079429
132MP0003632_abnormal_nervous_system0.72526068
133MP0002972_abnormal_cardiac_muscle0.71647508
134MP0003953_abnormal_hormone_level0.70590735
135MP0003300_gastrointestinal_ulcer0.70582444
136MP0006138_congestive_heart_failure0.69960684
137MP0003186_abnormal_redox_activity0.69374977
138MP0003806_abnormal_nucleotide_metabolis0.69274846
139MP0002735_abnormal_chemical_nociception0.68693488
140MP0004036_abnormal_muscle_relaxation0.68606347
141MP0004142_abnormal_muscle_tone0.67596982
142MP0001663_abnormal_digestive_system0.67008310
143MP0008569_lethality_at_weaning0.66988964
144MP0002089_abnormal_postnatal_growth/wei0.65996320
145MP0003172_abnormal_lysosome_physiology0.65843155
146MP0003868_abnormal_feces_composition0.65300742
147MP0005647_abnormal_sex_gland0.64900925
148MP0000230_abnormal_systemic_arterial0.64484232
149MP0000598_abnormal_liver_morphology0.64173445
150MP0002998_abnormal_bone_remodeling0.63662257
151MP0002557_abnormal_social/conspecific_i0.62167775
152MP0001545_abnormal_hematopoietic_system0.61819881
153MP0005397_hematopoietic_system_phenotyp0.61819881
154MP0002184_abnormal_innervation0.60908489
155MP0006036_abnormal_mitochondrial_physio0.60547677

Predicted human phenotypes

RankGene SetZ-score
1Abnormal platelet volume (HP:0011876)9.37002650
2Purpura (HP:0000979)8.86346985
3Petechiae (HP:0000967)7.31110360
4Epistaxis (HP:0000421)6.63293380
5Gingival bleeding (HP:0000225)6.39588516
6Acanthocytosis (HP:0001927)4.96626160
7Abnormal platelet function (HP:0011869)4.68615086
8Impaired platelet aggregation (HP:0003540)4.68615086
9Deep venous thrombosis (HP:0002625)4.46096074
10Focal motor seizures (HP:0011153)4.23440385
11Complement deficiency (HP:0004431)4.18333595
12Poikilocytosis (HP:0004447)4.18148426
13Xanthomatosis (HP:0000991)4.17923860
14Hyperlipoproteinemia (HP:0010980)4.06221553
15Myokymia (HP:0002411)3.81461359
16Epidermoid cyst (HP:0200040)3.66323899
17Oligomenorrhea (HP:0000876)3.60053140
18Spontaneous hematomas (HP:0007420)3.58020322
19Hyperglycinuria (HP:0003108)3.55371952
20Ketosis (HP:0001946)3.45745206
21Abnormality of aromatic amino acid family metabolism (HP:0004338)3.42305096
22Abnormality of glycine metabolism (HP:0010895)3.32475418
23Abnormality of serine family amino acid metabolism (HP:0010894)3.32475418
24Cerebral inclusion bodies (HP:0100314)3.27611089
25Intrahepatic cholestasis (HP:0001406)3.24739320
26Papillary thyroid carcinoma (HP:0002895)3.20021826
27Focal seizures (HP:0007359)3.16775737
28Conjunctival telangiectasia (HP:0000524)3.15580815
29Hypoalphalipoproteinemia (HP:0003233)3.14580958
30Hyperammonemia (HP:0001987)3.12757784
31Hyperventilation (HP:0002883)3.12635871
32Hypobetalipoproteinemia (HP:0003563)3.11168586
33Hyperglycinemia (HP:0002154)3.09106176
34Dyschromatopsia (HP:0007641)3.05807008
35Prolonged partial thromboplastin time (HP:0003645)3.05527082
36Acanthosis nigricans (HP:0000956)2.97798157
37Abnormality of the vasculature of the conjunctiva (HP:0008054)2.94122731
38Hypertriglyceridemia (HP:0002155)2.93516351
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.93062368
40Hypolipoproteinemia (HP:0010981)2.92220664
41Ketoacidosis (HP:0001993)2.91548276
42Neurofibrillary tangles (HP:0002185)2.89969234
43Abnormality of complement system (HP:0005339)2.87328417
44Visual hallucinations (HP:0002367)2.85864439
45Abnormal pupillary function (HP:0007686)2.82025621
46Impaired social interactions (HP:0000735)2.80511362
47Abnormal social behavior (HP:0012433)2.80511362
48Bruising susceptibility (HP:0000978)2.80157629
49Skin nodule (HP:0200036)2.79070041
50Poor eye contact (HP:0000817)2.71728483
51Abnormality of monocarboxylic acid metabolism (HP:0010996)2.70079268
52Pancreatic islet-cell hyperplasia (HP:0004510)2.68164927
53Abnormality of the lower motor neuron (HP:0002366)2.63055642
54Hypercholesterolemia (HP:0003124)2.60723864
55Abnormality of glutamine family amino acid metabolism (HP:0010902)2.55088931
56Hypoglycemic coma (HP:0001325)2.54910467
57Absence seizures (HP:0002121)2.52585128
58Generalized tonic-clonic seizures (HP:0002069)2.52035270
59Hypophosphatemic rickets (HP:0004912)2.50058638
60Abnormal eating behavior (HP:0100738)2.48965769
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.39936943
62Torticollis (HP:0000473)2.38568888
63Status epilepticus (HP:0002133)2.37020441
64Nausea (HP:0002018)2.36785495
65Abnormality of fatty-acid metabolism (HP:0004359)2.35193013
66Action tremor (HP:0002345)2.33077120
67Abnormality of the common coagulation pathway (HP:0010990)2.32625713
68Impaired vibration sensation in the lower limbs (HP:0002166)2.31984735
69Upper limb muscle weakness (HP:0003484)2.31838086
70Epileptic encephalopathy (HP:0200134)2.31608968
71Supranuclear gaze palsy (HP:0000605)2.30763244
72Amyloidosis (HP:0011034)2.30685041
73Focal dystonia (HP:0004373)2.26782589
74Abnormality of the Achilles tendon (HP:0005109)2.24940934
75Myocardial infarction (HP:0001658)2.22634338
76Atonic seizures (HP:0010819)2.21880525
77Sensorimotor neuropathy (HP:0007141)2.21431836
78Paralysis (HP:0003470)2.21058316
79Anxiety (HP:0000739)2.20338334
80Global brain atrophy (HP:0002283)2.20183130
81Transitional cell carcinoma of the bladder (HP:0006740)2.19516233
82Craniofacial dystonia (HP:0012179)2.19472378
83Abnormality of the heme biosynthetic pathway (HP:0010472)2.17014031
84Dialeptic seizures (HP:0011146)2.16733470
85Leiomyosarcoma (HP:0100243)2.16389268
86Uterine leiomyosarcoma (HP:0002891)2.16389268
87Arthropathy (HP:0003040)2.14231816
88Delayed CNS myelination (HP:0002188)2.13041054
89Joint swelling (HP:0001386)2.11818305
90Dysdiadochokinesis (HP:0002075)2.11260332
91Testicular neoplasm (HP:0010788)2.09126016
92Spontaneous abortion (HP:0005268)2.08799999
93Thyroid carcinoma (HP:0002890)2.08179365
94Abnormal gallbladder physiology (HP:0012438)2.07278297
95Cholecystitis (HP:0001082)2.07278297
96Amblyopia (HP:0000646)2.07148283
97Increased density of long bones (HP:0006392)2.05973166
98Drooling (HP:0002307)2.03971926
99Excessive salivation (HP:0003781)2.03971926
100Glomerulonephritis (HP:0000099)2.03435088
101Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.03059378
102Myoglobinuria (HP:0002913)2.02974699
103Abnormality of proline metabolism (HP:0010907)2.01821272
104Hydroxyprolinuria (HP:0003080)2.01821272
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.01487125
106Menorrhagia (HP:0000132)10.5262394
107Prolonged bleeding time (HP:0003010)10.4144201
108Increased mean platelet volume (HP:0011877)10.0953024
109Neonatal onset (HP:0003623)1.99548794
110Intention tremor (HP:0002080)1.98446620
111Depression (HP:0000716)1.98249110
112Joint hemorrhage (HP:0005261)1.96752848
113Dysmetria (HP:0001310)1.96140883
114Bladder neoplasm (HP:0009725)1.95851118
115Bladder carcinoma (HP:0002862)1.95851118
116Pigmentary retinal degeneration (HP:0001146)1.94615495
117Hyperthyroidism (HP:0000836)1.94408783
118Hepatosplenomegaly (HP:0001433)1.93764617
119Back pain (HP:0003418)1.92499504
120Postural instability (HP:0002172)1.91896761
121Achilles tendon contracture (HP:0001771)1.91581597
122Abnormality of lateral ventricle (HP:0030047)1.88925990
123Hemorrhage of the eye (HP:0011885)1.88820945
124Generalized aminoaciduria (HP:0002909)1.88293786
125Insidious onset (HP:0003587)1.87634288
126Termporal pattern (HP:0011008)1.87634288
127Dysmetric saccades (HP:0000641)1.87627727
128Abnormality of serum amino acid levels (HP:0003112)1.84570662
129Polycythemia (HP:0001901)1.82744329
130Impaired vibratory sensation (HP:0002495)1.82710631
131Cerebral hemorrhage (HP:0001342)1.82566681
132Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82020794
133Growth hormone excess (HP:0000845)1.81826539
134Abnormal auditory evoked potentials (HP:0006958)1.81384079
135Turricephaly (HP:0000262)1.80585459
136Febrile seizures (HP:0002373)1.80378760
137Systemic lupus erythematosus (HP:0002725)1.79682866
138Mitral stenosis (HP:0001718)1.79547459
139Epileptiform EEG discharges (HP:0011182)1.79257085
140Hemiplegia (HP:0002301)1.78616837
141Episodic fever (HP:0001954)1.77475933
142Thrombophlebitis (HP:0004418)1.76302472
143Polygenic inheritance (HP:0010982)1.75234645
144Polyphagia (HP:0002591)1.74837194
145Decreased central vision (HP:0007663)1.74370058
146Metabolic acidosis (HP:0001942)1.73788340
147Cholelithiasis (HP:0001081)1.73547178
148Resting tremor (HP:0002322)1.73188877
149Papilledema (HP:0001085)1.72325351
150Abnormality of macrophages (HP:0004311)1.65487898
151Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.62166254
152Broad palm (HP:0001169)1.62153546
153Broad alveolar ridges (HP:0000187)1.62017967
154Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.56483202
155Gonadal dysgenesis (HP:0000133)1.54672316
156Diplopia (HP:0000651)1.52550946
157Abnormality of binocular vision (HP:0011514)1.52550946
158Biliary tract neoplasm (HP:0100574)1.52477712
159Tetraparesis (HP:0002273)1.50933904
160Malignant gastrointestinal tract tumors (HP:0006749)1.49860289
161Gastrointestinal carcinoma (HP:0002672)1.49860289
162Rickets (HP:0002748)1.48002030
163Delayed puberty (HP:0000823)1.47822197
164Dysostosis multiplex (HP:0000943)1.46534146
165Abnormality of iron homeostasis (HP:0011031)1.39888036
166Irregular epiphyses (HP:0010582)1.39480424
167Arterial thrombosis (HP:0004420)1.36757688
168Renal cell carcinoma (HP:0005584)1.34353444
169Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.34344802
170Abnormality of alanine metabolism (HP:0010916)1.34344802
171Hyperalaninemia (HP:0003348)1.34344802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.92477135
2EIF2AK13.79523516
3NTRK33.51315294
4BMX3.41992886
5MST43.04133430
6MAP3K92.69999559
7DAPK22.68601050
8TRIB32.64519562
9MYLK2.45190939
10KSR22.41415594
11RIPK42.36224742
12MAP2K42.35433911
13CAMK1D2.32078542
14MAP3K42.24626303
15CAMK1G2.23756385
16MINK12.16298053
17BCKDK2.13755831
18TEC1.96613552
19SIK11.90231243
20STK31.87481569
21PRKD31.86416429
22MARK11.82766404
23PAK61.79611805
24CSF1R1.79128192
25TRIM281.71014031
26STK241.68816251
27TNIK1.68443732
28SYK1.64764080
29BTK1.63059659
30KSR11.61990497
31PTK2B1.60097256
32CAMKK11.54270687
33NTRK11.48579762
34MAP3K131.46810998
35MAP2K71.42815753
36DAPK11.38672925
37SIK21.35678981
38YES11.35130857
39RIPK11.29918082
40MAP3K21.29134422
41LATS21.29108275
42BCR1.27455938
43SIK31.24357097
44CDK51.23902372
45ILK1.19568727
46PDK31.18785163
47PDK41.18785163
48EPHA31.16668862
49MAP3K51.16288294
50PLK21.13905743
51RET1.11628975
52CASK1.11191669
53GRK51.11036429
54NTRK21.10439869
55MAP3K121.06892933
56STK381.06852409
57PKN21.05859334
58ARAF1.05743666
59SGK21.04707418
60FGFR21.03921276
61LMTK21.00997494
62MAP2K11.00989414
63MST1R0.98643261
64RAF10.97029724
65PDPK10.95581067
66ZAP700.95334543
67ACVR1B0.94473485
68DYRK20.93897881
69TYRO30.93432720
70INSRR0.92960707
71FRK0.91382780
72ERBB20.90395409
73PRKCG0.90212538
74FES0.88836000
75PDK10.88520285
76HCK0.88411280
77PINK10.84370581
78DYRK1B0.83724603
79MAP3K70.83401297
80CAMK10.82794567
81MAP3K60.80440038
82PRKCH0.80052645
83PAK30.79576281
84FER0.79023399
85BMPR20.78408910
86CAMK2A0.77710942
87PDGFRA0.76721597
88ADRBK20.76365704
89MATK0.75499818
90PIK3CG0.75029038
91PRKAA20.73498051
92PDGFRB0.73296555
93PRKCZ0.72703254
94PAK10.69970187
95ERN10.69598268
96STK110.68171954
97LYN0.67485457
98PHKG20.67166652
99PHKG10.67166652
100NEK90.66980746
101PRKG10.66471823
102BLK0.66288636
103MAPK130.65867219
104PKN10.63890917
105IRAK10.62221706
106CAMK2B0.61305892
107MAPK120.60264098
108CSK0.59063210
109CAMKK20.58402516
110PRKACG0.56485779
111FGFR40.56422968
112SGK10.55835755
113FGR0.55333982
114MAP3K10.55316381
115ABL20.55097801
116PNCK0.55064338
117TAOK10.51689543
118ADRBK10.51461918
119FGFR30.51166226
120MAP2K30.50644966
121PRPF4B0.50009045
122CDK140.48771219
123SGK30.48669890
124MAP4K20.48324732
125DYRK1A0.47352886
126JAK20.46687204
127DDR20.45705933
128GRK60.45329362
129SGK4940.44843626
130SGK2230.44843626
131EPHB20.44426044
132FGFR10.44208920
133RPS6KA30.43937026
134CDK150.43451065
135CDK180.42301702
136ERBB30.42237905
137FYN0.41859616
138PRKD10.41513631
139SRC0.41478849
140TGFBR20.41157526
141CSNK1G20.40860859
142MARK20.40693296
143PRKAA10.40492958
144PDK20.40034701
145TAOK30.39290668
146MOS0.38378065
147DAPK30.37010083
148CAMK2G0.36335200
149JAK10.34798969

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046114.35185017
2Nitrogen metabolism_Homo sapiens_hsa009103.50399900
3Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.88831565
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.83313521
5PPAR signaling pathway_Homo sapiens_hsa033202.46771078
6Arginine biosynthesis_Homo sapiens_hsa002202.28229931
7Propanoate metabolism_Homo sapiens_hsa006402.24352146
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.23390775
9ECM-receptor interaction_Homo sapiens_hsa045122.21021728
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06898251
11Fatty acid degradation_Homo sapiens_hsa000712.04568112
12Fatty acid metabolism_Homo sapiens_hsa012121.96641984
13Fatty acid biosynthesis_Homo sapiens_hsa000611.92091210
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.87146501
15Steroid biosynthesis_Homo sapiens_hsa001001.85405029
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.82641254
17Butanoate metabolism_Homo sapiens_hsa006501.77145473
18Nicotine addiction_Homo sapiens_hsa050331.73915502
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.71422627
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.71384242
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68417671
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.61865860
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61377279
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60773012
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.60622544
26Tryptophan metabolism_Homo sapiens_hsa003801.50019008
27Complement and coagulation cascades_Homo sapiens_hsa046101.49158419
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47656559
29Glycerolipid metabolism_Homo sapiens_hsa005611.44702870
30Long-term potentiation_Homo sapiens_hsa047201.43603152
31Chemokine signaling pathway_Homo sapiens_hsa040621.43419366
32Pyruvate metabolism_Homo sapiens_hsa006201.36523517
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34230325
34Bile secretion_Homo sapiens_hsa049761.32633095
35GABAergic synapse_Homo sapiens_hsa047271.32181728
36Circadian entrainment_Homo sapiens_hsa047131.30268887
37Peroxisome_Homo sapiens_hsa041461.29344737
38Hematopoietic cell lineage_Homo sapiens_hsa046401.29189265
39Renin secretion_Homo sapiens_hsa049241.28166702
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.25766209
41beta-Alanine metabolism_Homo sapiens_hsa004101.25751935
42Glutamatergic synapse_Homo sapiens_hsa047241.23542660
43Salivary secretion_Homo sapiens_hsa049701.22451015
44Caffeine metabolism_Homo sapiens_hsa002321.20363743
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19654371
46Amphetamine addiction_Homo sapiens_hsa050311.19326218
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16999589
48Synaptic vesicle cycle_Homo sapiens_hsa047211.15105320
49Morphine addiction_Homo sapiens_hsa050321.13942789
50Olfactory transduction_Homo sapiens_hsa047401.12119684
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08924240
52Alcoholism_Homo sapiens_hsa050341.08625917
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08287627
54Rap1 signaling pathway_Homo sapiens_hsa040151.06573036
55Phenylalanine metabolism_Homo sapiens_hsa003601.05690343
56Endocytosis_Homo sapiens_hsa041441.02423905
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02065211
58Dopaminergic synapse_Homo sapiens_hsa047281.00267688
59Carbon metabolism_Homo sapiens_hsa012001.00064258
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99343468
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97905505
62Fat digestion and absorption_Homo sapiens_hsa049750.96879563
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.93244290
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90637528
65Collecting duct acid secretion_Homo sapiens_hsa049660.90420263
66Staphylococcus aureus infection_Homo sapiens_hsa051500.89951914
67Glucagon signaling pathway_Homo sapiens_hsa049220.88984916
68Gastric acid secretion_Homo sapiens_hsa049710.87282446
69Focal adhesion_Homo sapiens_hsa045100.86702894
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86233709
71Tyrosine metabolism_Homo sapiens_hsa003500.85880964
72Renin-angiotensin system_Homo sapiens_hsa046140.84288877
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82761369
74Oxytocin signaling pathway_Homo sapiens_hsa049210.82152923
75Cholinergic synapse_Homo sapiens_hsa047250.81082990
76Choline metabolism in cancer_Homo sapiens_hsa052310.80982065
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80579214
78Adherens junction_Homo sapiens_hsa045200.80153623
79Ras signaling pathway_Homo sapiens_hsa040140.79165965
80AMPK signaling pathway_Homo sapiens_hsa041520.78430296
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77352940
82Chemical carcinogenesis_Homo sapiens_hsa052040.75827195
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74601811
84Calcium signaling pathway_Homo sapiens_hsa040200.74383301
85Type II diabetes mellitus_Homo sapiens_hsa049300.74137254
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73614463
87Arachidonic acid metabolism_Homo sapiens_hsa005900.73608586
88Insulin secretion_Homo sapiens_hsa049110.73306238
89Non-small cell lung cancer_Homo sapiens_hsa052230.72659261
90Phagosome_Homo sapiens_hsa041450.72374391
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69911983
92cAMP signaling pathway_Homo sapiens_hsa040240.69488144
93Pancreatic cancer_Homo sapiens_hsa052120.68398768
94Endometrial cancer_Homo sapiens_hsa052130.68285927
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67860335
96B cell receptor signaling pathway_Homo sapiens_hsa046620.67709040
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67689086
98Long-term depression_Homo sapiens_hsa047300.66640394
99Starch and sucrose metabolism_Homo sapiens_hsa005000.65672143
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.65031897
101Systemic lupus erythematosus_Homo sapiens_hsa053220.64244728
102Pancreatic secretion_Homo sapiens_hsa049720.64217605
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.63739875
104Biosynthesis of amino acids_Homo sapiens_hsa012300.63130048
105Insulin signaling pathway_Homo sapiens_hsa049100.61767196
106GnRH signaling pathway_Homo sapiens_hsa049120.60963552
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60119285
108Cocaine addiction_Homo sapiens_hsa050300.59856841
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.59039870
110Renal cell carcinoma_Homo sapiens_hsa052110.58638243
111Ovarian steroidogenesis_Homo sapiens_hsa049130.58310954
112Insulin resistance_Homo sapiens_hsa049310.58127996
113Fatty acid elongation_Homo sapiens_hsa000620.57929329
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57266820
115Glioma_Homo sapiens_hsa052140.57024599
116ABC transporters_Homo sapiens_hsa020100.56591204
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56134417
118Prion diseases_Homo sapiens_hsa050200.55320068
119Taste transduction_Homo sapiens_hsa047420.53961733
120Retinol metabolism_Homo sapiens_hsa008300.53595246
121Shigellosis_Homo sapiens_hsa051310.53210109
122Gap junction_Homo sapiens_hsa045400.51817513
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50698771
124Histidine metabolism_Homo sapiens_hsa003400.49748275
125Estrogen signaling pathway_Homo sapiens_hsa049150.48154937
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47316119
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47077358
128Serotonergic synapse_Homo sapiens_hsa047260.46060854
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44226032
130Thyroid hormone synthesis_Homo sapiens_hsa049180.44165148
131T cell receptor signaling pathway_Homo sapiens_hsa046600.42223602
132Melanogenesis_Homo sapiens_hsa049160.41622705
133HIF-1 signaling pathway_Homo sapiens_hsa040660.41426189
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40754447
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40712859
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.40701038
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.40353354
138Malaria_Homo sapiens_hsa051440.39964494
139Dilated cardiomyopathy_Homo sapiens_hsa054140.39566811
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.39149833
141Osteoclast differentiation_Homo sapiens_hsa043800.38741929
142Axon guidance_Homo sapiens_hsa043600.38610585
143Amoebiasis_Homo sapiens_hsa051460.38193214
144VEGF signaling pathway_Homo sapiens_hsa043700.36512956
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36318154
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.34595248
147Sulfur metabolism_Homo sapiens_hsa009200.33651772

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