MME

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)5.34097981
2intestinal cholesterol absorption (GO:0030299)5.05691223
3* angiotensin maturation (GO:0002003)4.95373811
4regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.60753415
5iron ion import (GO:0097286)4.55987473
6detection of molecule of bacterial origin (GO:0032490)4.43541604
7hormone catabolic process (GO:0042447)4.18888798
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.95520701
9positive regulation by organism of defense response of other organism involved in symbiotic interact3.95520701
10modulation by symbiont of host immune response (GO:0052553)3.95520701
11positive regulation by symbiont of host defense response (GO:0052509)3.95520701
12modulation by symbiont of host defense response (GO:0052031)3.95520701
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.95520701
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.93879247
15prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.92178847
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.90521663
17negative regulation of fatty acid transport (GO:2000192)3.81368269
18regulation of triglyceride catabolic process (GO:0010896)3.74843681
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.74267572
20lipoprotein transport (GO:0042953)3.73134037
21import into cell (GO:0098657)3.70814612
22branching involved in prostate gland morphogenesis (GO:0060442)3.68710162
23positive regulation of fatty acid beta-oxidation (GO:0032000)3.63801600
24drug catabolic process (GO:0042737)3.58821461
25UDP-N-acetylglucosamine metabolic process (GO:0006047)3.54122568
26anterior/posterior axis specification, embryo (GO:0008595)3.53061156
27lysine catabolic process (GO:0006554)3.52651219
28lysine metabolic process (GO:0006553)3.52651219
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.51605185
30negative regulation of sterol transport (GO:0032372)3.51215777
31negative regulation of cholesterol transport (GO:0032375)3.51215777
32antigen processing and presentation of endogenous antigen (GO:0019883)3.44155783
33positive regulation of macrophage cytokine production (GO:0060907)3.43635684
34regulation of interferon-beta biosynthetic process (GO:0045357)3.33711670
35NADH metabolic process (GO:0006734)3.33632537
36cysteine metabolic process (GO:0006534)3.31979270
37detection of external biotic stimulus (GO:0098581)3.31562596
38hypotonic response (GO:0006971)3.25059178
39homocysteine metabolic process (GO:0050667)3.24917322
40lipoprotein metabolic process (GO:0042157)3.24609487
41macrophage activation involved in immune response (GO:0002281)3.23398936
42positive regulation of lipid catabolic process (GO:0050996)3.22177579
43reverse cholesterol transport (GO:0043691)3.21229657
44regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.20574356
45cholesterol efflux (GO:0033344)3.19146561
46vitamin A metabolic process (GO:0006776)3.17740311
47drug transmembrane transport (GO:0006855)3.15104976
48peptide catabolic process (GO:0043171)3.13725945
49positive regulation of catenin import into nucleus (GO:0035413)3.13628176
50high-density lipoprotein particle remodeling (GO:0034375)3.13179785
51midgut development (GO:0007494)3.11800022
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.08371491
53negative regulation of cell killing (GO:0031342)3.08371491
54positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.05434829
55epoxygenase P450 pathway (GO:0019373)3.05186401
56regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.04795525
57phospholipid efflux (GO:0033700)3.04165897
58flavonoid metabolic process (GO:0009812)3.02963104
59positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.02503529
60virion attachment to host cell (GO:0019062)2.96654619
61adhesion of symbiont to host cell (GO:0044650)2.96654619
62transepithelial transport (GO:0070633)2.95843191
63transcytosis (GO:0045056)2.95800424
64positive regulation of fatty acid oxidation (GO:0046321)2.95284686
65fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.95075880
66alpha-linolenic acid metabolic process (GO:0036109)2.95022893
67vascular endothelial growth factor signaling pathway (GO:0038084)2.93215723
68fibril organization (GO:0097435)2.92247558
69detection of other organism (GO:0098543)2.91921273
70regulation of extracellular matrix disassembly (GO:0010715)2.91439160
71sulfur amino acid catabolic process (GO:0000098)2.90888357
72epithelial cell differentiation involved in prostate gland development (GO:0060742)2.90855240
73plasma lipoprotein particle assembly (GO:0034377)2.89573979
74regulation of fatty acid beta-oxidation (GO:0031998)2.89049454
75cellular extravasation (GO:0045123)2.87890009
76renal filtration (GO:0097205)2.87464491
77glomerular basement membrane development (GO:0032836)2.87461517
78positive regulation of triglyceride lipase activity (GO:0061365)2.87232697
79positive regulation of lipoprotein lipase activity (GO:0051006)2.87232697
80linoleic acid metabolic process (GO:0043651)2.85737937
81protein localization to endosome (GO:0036010)2.85408908
82hippo signaling (GO:0035329)2.84697415
83urea cycle (GO:0000050)2.84130312
84urea metabolic process (GO:0019627)2.84130312
85embryonic process involved in female pregnancy (GO:0060136)2.83948264
86drug transport (GO:0015893)2.82501815
87hemidesmosome assembly (GO:0031581)2.81774818
88artery development (GO:0060840)2.81165935
89sequestering of extracellular ligand from receptor (GO:0035581)2.80794684
90protein-lipid complex assembly (GO:0065005)2.79149501
91diacylglycerol metabolic process (GO:0046339)2.78130835
92response to phenylpropanoid (GO:0080184)2.77279183
93regulation of cholesterol esterification (GO:0010872)2.75250465
94endodermal cell differentiation (GO:0035987)2.72947804
95valine metabolic process (GO:0006573)2.72678357
96sterol homeostasis (GO:0055092)2.72591069
97skin morphogenesis (GO:0043589)2.72320027
98detection of biotic stimulus (GO:0009595)2.71105214
99regulation of cholesterol homeostasis (GO:2000188)2.70840161
100low-density lipoprotein particle clearance (GO:0034383)2.70449413
101cholesterol homeostasis (GO:0042632)2.70383882
102regulation of macrophage cytokine production (GO:0010935)2.70173197
103cell migration involved in heart development (GO:0060973)2.69337336
104intestinal epithelial cell development (GO:0060576)2.66461306
105response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.65827355
106response to host immune response (GO:0052572)2.65827355
107fatty acid beta-oxidation (GO:0006635)2.64726735
108endocardial cushion development (GO:0003197)2.64013251
109response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64006370
110response to host (GO:0075136)2.64006370
111response to host defenses (GO:0052200)2.64006370
112interleukin-6-mediated signaling pathway (GO:0070102)2.62692096
113apoptotic cell clearance (GO:0043277)2.62633198
114adhesion of symbiont to host (GO:0044406)2.61556674
115protein heterotrimerization (GO:0070208)2.61529085
116regulation of T-helper 2 cell differentiation (GO:0045628)2.60816704
117embryonic retina morphogenesis in camera-type eye (GO:0060059)2.60487543
118cellular modified amino acid catabolic process (GO:0042219)2.59308305
119insulin-like growth factor receptor signaling pathway (GO:0048009)2.58023282
120protein-lipid complex remodeling (GO:0034368)2.57925374
121macromolecular complex remodeling (GO:0034367)2.57925374
122plasma lipoprotein particle remodeling (GO:0034369)2.57925374
123multicellular organismal catabolic process (GO:0044243)2.57859503
124extracellular fibril organization (GO:0043206)2.57666907
125triglyceride biosynthetic process (GO:0019432)2.56964331
126very-low-density lipoprotein particle assembly (GO:0034379)2.55621694
127glomerular filtration (GO:0003094)2.54243161
128amino-acid betaine metabolic process (GO:0006577)2.53884757
129cholesterol transport (GO:0030301)2.53825952
130sterol transport (GO:0015918)2.53825952
131modified amino acid transport (GO:0072337)2.52863114
132COPII vesicle coating (GO:0048208)2.52396705
133positive regulation of histone deacetylation (GO:0031065)2.51096963
134triglyceride catabolic process (GO:0019433)2.50660384
135regulation of bile acid biosynthetic process (GO:0070857)2.49505952
136sulfate transmembrane transport (GO:1902358)2.49048654
137ethanol oxidation (GO:0006069)2.48620543
138multicellular organismal metabolic process (GO:0044236)2.48348588
139nitrogen cycle metabolic process (GO:0071941)2.48340112
140positive regulation of blood vessel endothelial cell migration (GO:0043536)2.48162277
141short-chain fatty acid metabolic process (GO:0046459)2.48124778
142drug metabolic process (GO:0017144)2.46933011
143negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.46589538
144fatty acid oxidation (GO:0019395)2.45903150
145collagen fibril organization (GO:0030199)2.44589465
146basement membrane organization (GO:0071711)2.44382075
147long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.43578417
148multicellular organismal macromolecule metabolic process (GO:0044259)2.43235257
149G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.43084035
150carnitine shuttle (GO:0006853)2.41247795
151glomerular visceral epithelial cell development (GO:0072015)2.40661813
152positive regulation of mesenchymal cell proliferation (GO:0002053)2.40655316
153positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.40375987
154negative regulation of cell fate specification (GO:0009996)2.40299314
155bone morphogenesis (GO:0060349)2.40059348
156antigen processing and presentation via MHC class Ib (GO:0002475)2.39980525
157lipid oxidation (GO:0034440)2.38876177
158prostate gland epithelium morphogenesis (GO:0060740)2.38137616
159positive regulation of fatty acid metabolic process (GO:0045923)2.38129768
160neutral lipid biosynthetic process (GO:0046460)2.38093558
161acylglycerol biosynthetic process (GO:0046463)2.38093558
162extracellular matrix assembly (GO:0085029)2.35387051
163detection of bacterium (GO:0016045)2.35091964
164growth hormone receptor signaling pathway (GO:0060396)2.34794443
165regulation of sequestering of triglyceride (GO:0010889)2.34595165
166regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.34476551
167blood vessel maturation (GO:0001955)2.32984869
168tooth mineralization (GO:0034505)2.32379094
169response to peptidoglycan (GO:0032494)2.31455797
170positive regulation of receptor recycling (GO:0001921)2.31199817
171positive regulation of Cdc42 GTPase activity (GO:0043089)2.31180074
172chondrocyte development (GO:0002063)2.30373668
173negative regulation of protein localization to plasma membrane (GO:1903077)2.29763318
174negative regulation of type 2 immune response (GO:0002829)2.28989588
175collagen metabolic process (GO:0032963)2.28770605
176positive regulation of gamma-delta T cell activation (GO:0046645)2.28501992
177negative regulation of T-helper cell differentiation (GO:0045623)2.28500410
178negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.28500410
179macrophage activation (GO:0042116)2.28318631
180positive regulation of endothelial cell apoptotic process (GO:2000353)2.28014271
181bone trabecula formation (GO:0060346)2.25600622
182dendritic cell migration (GO:0036336)2.24390358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.17474769
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.04527427
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.34643874
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.32332597
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.28753682
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.24942770
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.15529561
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.96462438
9* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.93714433
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.88610617
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.62927174
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.48635846
13CLOCK_20551151_ChIP-Seq_293T_Human2.37896353
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.36669903
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.32773356
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.30885744
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.25250896
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.25137303
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17611659
20SOX2_27498859_Chip-Seq_STOMACH_Mouse2.16702234
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15709161
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.13038698
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07869532
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.05483214
25* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.03294194
26PPAR_26484153_Chip-Seq_NCI-H1993_Human2.01283904
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.00326078
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.97668160
29GATA4_25053715_ChIP-Seq_YYC3_Human1.96346723
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.91003355
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.88503792
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87794792
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85646207
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85372462
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.83479308
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.75172529
37* SOX2_20726797_ChIP-Seq_SW620_Human1.73749843
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72100970
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.71470100
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70679350
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70194941
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69608606
43VDR_24763502_ChIP-Seq_THP-1_Human1.69534230
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.68217827
45SALL4_18804426_ChIP-ChIP_XEN_Mouse1.67861024
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.67586178
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.64566733
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.63823618
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63052953
50* SALL1_21062744_ChIP-ChIP_HESCs_Human1.57767509
51VDR_24787735_ChIP-Seq_THP-1_Human1.56985619
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56489458
53GATA6_25053715_ChIP-Seq_YYC3_Human1.55811799
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54951946
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53648758
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.53112578
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.52934819
58RUNX_20019798_ChIP-Seq_JUKART_Human1.51622803
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.50643007
60AHR_22903824_ChIP-Seq_MCF-7_Human1.49622731
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45899727
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.42915808
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41166870
64* BRD4_25478319_ChIP-Seq_HGPS_Human1.41038447
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39638254
66* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38409714
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38109440
68ZNF263_19887448_ChIP-Seq_K562_Human1.36464971
69CJUN_26792858_Chip-Seq_BT549_Human1.36111123
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.35717316
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34136243
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.33836857
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.33337803
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31504086
75* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31193150
76SPI1_23127762_ChIP-Seq_K562_Human1.29659224
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27952221
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27719320
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26010957
80VDR_21846776_ChIP-Seq_THP-1_Human1.25819766
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24701760
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24701760
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24701760
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24615183
85WT1_19549856_ChIP-ChIP_CCG9911_Human1.23838512
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22718033
87TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22240207
88* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.21696411
89CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21588896
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.21444084
91AR_21909140_ChIP-Seq_LNCAP_Human1.20945185
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.20161846
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19756225
94ISL1_27105846_Chip-Seq_CPCs_Mouse1.19013397
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18950809
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18950809
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18594760
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18357593
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17907649
100* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17900360
101TCF7_22412390_ChIP-Seq_EML_Mouse1.17815045
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16920758
103* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16541838
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14864170
105HNF4A_19822575_ChIP-Seq_HepG2_Human1.14497236
106RACK7_27058665_Chip-Seq_MCF-7_Human1.12927699
107STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12838220
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11652231
109SPI1_23547873_ChIP-Seq_NB4_Human1.11597879
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10615963
111RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10450920
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09459623
113GATA3_24758297_ChIP-Seq_MCF-7_Human1.08468300
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08372773
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08372773
116TBX20_22328084_ChIP-Seq_HEART_Mouse1.07971325
117TBX20_22080862_ChIP-Seq_HEART_Mouse1.07971325
118PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07776177
119TP53_18474530_ChIP-ChIP_U2OS_Human1.07767860
120SMAD3_21741376_ChIP-Seq_HESCs_Human1.07604085
121EGR1_19374776_ChIP-ChIP_THP-1_Human1.05260543
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05225925
123TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05128251
124* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04396253
125GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04227341
126THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02666096
127GATA1_22025678_ChIP-Seq_K562_Human1.01069380
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01016566
129KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99710232
130* CHD1_26751641_Chip-Seq_LNCaP_Human0.99452086
131GATA1_19941827_ChIP-Seq_MEL_Mouse0.98746296
132* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98674824
133RXR_22108803_ChIP-Seq_LS180_Human0.98535605
134MYB_26560356_Chip-Seq_TH1_Human0.97420978
135* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97204987
136KDM2B_26808549_Chip-Seq_DND41_Human0.96555940
137* TP63_23658742_ChIP-Seq_EP156T_Human0.96467646
138KLF5_25053715_ChIP-Seq_YYC3_Human0.96381736
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96268001
140WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96244172
141ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96217166
142GATA1_19941826_ChIP-Seq_K562_Human0.95514056
143TP53_16413492_ChIP-PET_HCT116_Human0.95485352
144KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95032027
145EGR1_19032775_ChIP-ChIP_M12_Human0.94247646
146P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93890496
147TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.93796449
148WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93678024
149* GATA2_19941826_ChIP-Seq_K562_Human0.93521030
150CDX2_22108803_ChIP-Seq_LS180_Human0.93087093
151PU_27001747_Chip-Seq_BMDM_Mouse0.93073675
152JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92275002
153CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91708099
154* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90727968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.98838408
2MP0002139_abnormal_hepatobiliary_system4.19996436
3MP0010234_abnormal_vibrissa_follicle3.96545685
4MP0004858_abnormal_nervous_system3.44514463
5MP0001666_abnormal_nutrient_absorption3.30777844
6MP0005451_abnormal_body_composition3.11115105
7MP0003252_abnormal_bile_duct3.10703507
8MP0008438_abnormal_cutaneous_collagen3.05215097
9MP0003724_increased_susceptibility_to2.95154950
10MP0003705_abnormal_hypodermis_morpholog2.88234463
11MP0000537_abnormal_urethra_morphology2.83652271
12MP0005275_abnormal_skin_tensile2.64622160
13MP0005085_abnormal_gallbladder_physiolo2.60807357
14MP0008875_abnormal_xenobiotic_pharmacok2.41125203
15MP0005365_abnormal_bile_salt2.34086339
16MP0003279_aneurysm2.31120324
17MP0004264_abnormal_extraembryonic_tissu2.30995301
18MP0005503_abnormal_tendon_morphology2.23932817
19MP0010329_abnormal_lipoprotein_level2.22688035
20MP0004272_abnormal_basement_membrane2.14872203
21MP0009384_cardiac_valve_regurgitation2.14155746
22MP0004019_abnormal_vitamin_homeostasis1.99488833
23MP0003436_decreased_susceptibility_to1.81962552
24MP0000566_synostosis1.79570035
25MP0000462_abnormal_digestive_system1.77054382
26MP0009053_abnormal_anal_canal1.73924501
27MP0003300_gastrointestinal_ulcer1.72718704
28MP0003091_abnormal_cell_migration1.71603337
29MP0002254_reproductive_system_inflammat1.70666199
30MP0005332_abnormal_amino_acid1.69691670
31MP0009780_abnormal_chondrocyte_physiolo1.68526796
32MP0001835_abnormal_antigen_presentation1.67361929
33MP0000534_abnormal_ureter_morphology1.61325828
34MP0005164_abnormal_response_to1.57084331
35MP0001542_abnormal_bone_strength1.50000624
36MP0002971_abnormal_brown_adipose1.49724483
37MP0008260_abnormal_autophagy1.48215113
38MP0004130_abnormal_muscle_cell1.47875227
39MP0004883_abnormal_blood_vessel1.44863518
40MP0003828_pulmonary_edema1.41601922
41MP0010352_gastrointestinal_tract_polyps1.40039428
42MP0000538_abnormal_urinary_bladder1.39856178
43MP0001533_abnormal_skeleton_physiology1.38306934
44MP0001958_emphysema1.36084246
45MP0009643_abnormal_urine_homeostasis1.35591796
46MP0004043_abnormal_pH_regulation1.34523485
47MP0005248_abnormal_Harderian_gland1.33663244
48* MP0004947_skin_inflammation1.31711467
49MP0000685_abnormal_immune_system1.31514975
50MP0005409_darkened_coat_color1.30624252
51MP0009785_altered_susceptibility_to1.29241134
52MP0006054_spinal_hemorrhage1.27314514
53MP0010155_abnormal_intestine_physiology1.27308713
54MP0003941_abnormal_skin_development1.25700700
55MP0009840_abnormal_foam_cell1.25384616
56MP0002006_tumorigenesis1.24613451
57MP0004185_abnormal_adipocyte_glucose1.24136853
58MP0002896_abnormal_bone_mineralization1.23078760
59MP0010030_abnormal_orbit_morphology1.20736290
60MP0002419_abnormal_innate_immunity1.20534660
61MP0003385_abnormal_body_wall1.19233044
62MP0002132_abnormal_respiratory_system1.17839773
63MP0000762_abnormal_tongue_morphology1.16943164
64MP0010678_abnormal_skin_adnexa1.15563489
65MP0002998_abnormal_bone_remodeling1.15464327
66MP0003448_altered_tumor_morphology1.14890522
67MP0005666_abnormal_adipose_tissue1.14270561
68MP0000516_abnormal_urinary_system1.13701575
69MP0005367_renal/urinary_system_phenotyp1.13701575
70MP0001849_ear_inflammation1.13366212
71MP0002796_impaired_skin_barrier1.12167840
72MP0003283_abnormal_digestive_organ1.09156703
73MP0003937_abnormal_limbs/digits/tail_de1.08339207
74MP0001756_abnormal_urination1.06677578
75MP0000767_abnormal_smooth_muscle1.06004222
76MP0001346_abnormal_lacrimal_gland1.04775092
77MP0005623_abnormal_meninges_morphology1.04480658
78MP0010386_abnormal_urinary_bladder1.04377728
79MP0000858_altered_metastatic_potential1.04173266
80MP0001243_abnormal_dermal_layer1.03949164
81MP0002060_abnormal_skin_morphology1.03480676
82MP0006082_CNS_inflammation1.03211796
83MP0009250_abnormal_appendicular_skeleto1.03030589
84MP0002118_abnormal_lipid_homeostasis1.02330197
85MP0003942_abnormal_urinary_system1.01596910
86MP0005647_abnormal_sex_gland1.01290844
87MP0005390_skeleton_phenotype0.99171957
88MP0002009_preneoplasia0.98294625
89MP0005257_abnormal_intraocular_pressure0.97066015
90MP0005166_decreased_susceptibility_to0.96436185
91MP0005025_abnormal_response_to0.95601987
92MP0003566_abnormal_cell_adhesion0.95480033
93MP0003868_abnormal_feces_composition0.94534653
94MP0004233_abnormal_muscle_weight0.94322329
95MP0003303_peritoneal_inflammation0.94028482
96MP0009115_abnormal_fat_cell0.92085663
97MP0003045_fibrosis0.91926325
98MP0006138_congestive_heart_failure0.91805131
99MP0002136_abnormal_kidney_physiology0.90778633
100MP0000609_abnormal_liver_physiology0.90498691
101MP0002115_abnormal_skeleton_extremities0.90279202
102MP0003950_abnormal_plasma_membrane0.89912403
103MP0005023_abnormal_wound_healing0.89587934
104MP0000163_abnormal_cartilage_morphology0.89416267
105MP0000613_abnormal_salivary_gland0.89104454
106MP0001765_abnormal_ion_homeostasis0.88901770
107MP0003806_abnormal_nucleotide_metabolis0.88560306
108MP0005377_hearing/vestibular/ear_phenot0.88010871
109MP0003878_abnormal_ear_physiology0.88010871
110MP0002396_abnormal_hematopoietic_system0.87145546
111MP0009697_abnormal_copulation0.86856376
112MP0005000_abnormal_immune_tolerance0.86249186
113MP0001790_abnormal_immune_system0.85666623
114MP0005387_immune_system_phenotype0.85666623
115MP0003183_abnormal_peptide_metabolism0.85196761
116MP0003075_altered_response_to0.85068524
117MP0002249_abnormal_larynx_morphology0.83763479
118MP0002166_altered_tumor_susceptibility0.82825899
119MP0002098_abnormal_vibrissa_morphology0.82326060
120MP0005058_abnormal_lysosome_morphology0.82257819
121MP0001800_abnormal_humoral_immune0.81921783
122MP0000249_abnormal_blood_vessel0.79643118
123MP0002111_abnormal_tail_morphology0.79544488
124MP0002168_other_aberrant_phenotype0.79118135
125MP0005319_abnormal_enzyme/_coenzyme0.78358138
126MP0002295_abnormal_pulmonary_circulatio0.77358147
127MP0005595_abnormal_vascular_smooth0.76860091
128MP0003172_abnormal_lysosome_physiology0.76311488
129MP0005076_abnormal_cell_differentiation0.75167815
130MP0003115_abnormal_respiratory_system0.75038906
131MP0003191_abnormal_cellular_cholesterol0.74383784
132MP0003195_calcinosis0.74110603
133MP0003795_abnormal_bone_structure0.73886508
134MP0005375_adipose_tissue_phenotype0.73583000
135MP0001845_abnormal_inflammatory_respons0.73496276
136MP0005508_abnormal_skeleton_morphology0.73411654
137MP0003755_abnormal_palate_morphology0.72024875
138MP0003935_abnormal_craniofacial_develop0.71712667
139MP0002133_abnormal_respiratory_system0.70744709
140MP0005388_respiratory_system_phenotype0.70744709
141MP0008004_abnormal_stomach_pH0.70325629
142MP0002452_abnormal_antigen_presenting0.69959062
143MP0000477_abnormal_intestine_morphology0.69438864
144MP0002723_abnormal_immune_serum0.69265912
145MP0002282_abnormal_trachea_morphology0.69121314
146MP0005464_abnormal_platelet_physiology0.68977497
147MP0002108_abnormal_muscle_morphology0.68890773
148MP0002876_abnormal_thyroid_physiology0.68783582
149MP0004885_abnormal_endolymph0.68257172
150MP0000569_abnormal_digit_pigmentation0.67619046
151MP0005670_abnormal_white_adipose0.67565483
152MP0003959_abnormal_lean_body0.67556992
153MP0003315_abnormal_perineum_morphology0.67079390
154MP0002932_abnormal_joint_morphology0.66256135
155MP0002138_abnormal_hepatobiliary_system0.64079809
156MP0001299_abnormal_eye_distance/0.63956713
157MP0004782_abnormal_surfactant_physiolog0.63493423
158MP0000432_abnormal_head_morphology0.63289270
159MP0001177_atelectasis0.63265078
160MP0005501_abnormal_skin_physiology0.62179824

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)4.74026229
2Peritonitis (HP:0002586)4.70722079
3Abnormality of proline metabolism (HP:0010907)4.19642328
4Hydroxyprolinuria (HP:0003080)4.19642328
5Hyperglycinuria (HP:0003108)3.81196180
6Vascular tortuosity (HP:0004948)3.61449785
7Facial shape deformation (HP:0011334)3.53449493
8Potter facies (HP:0002009)3.53449493
9Soft skin (HP:0000977)3.35659519
10Hypobetalipoproteinemia (HP:0003563)3.28218886
11Dilatation of the ascending aorta (HP:0005111)3.26659417
12Type 1 muscle fiber predominance (HP:0003803)3.25770695
13Protrusio acetabuli (HP:0003179)3.25199763
14Ankle contracture (HP:0006466)3.22433614
15Increased variability in muscle fiber diameter (HP:0003557)3.18091716
16Blue sclerae (HP:0000592)3.17429505
17Eczematoid dermatitis (HP:0000976)3.02028508
18Overgrowth (HP:0001548)2.95460052
19Abnormality of glycine metabolism (HP:0010895)2.95384040
20Abnormality of serine family amino acid metabolism (HP:0010894)2.95384040
21Thin bony cortex (HP:0002753)2.93640960
22Slender build (HP:0001533)2.92859484
23Vertebral compression fractures (HP:0002953)2.91932866
24Sparse lateral eyebrow (HP:0005338)2.90990867
25Bladder diverticulum (HP:0000015)2.89657198
26Widely patent fontanelles and sutures (HP:0004492)2.86727748
27Arterial tortuosity (HP:0005116)2.85439700
28Atrophic scars (HP:0001075)2.81532066
29Mesangial abnormality (HP:0001966)2.81372071
30Genu recurvatum (HP:0002816)2.80025919
31Rectal prolapse (HP:0002035)2.79596882
32Lymphangioma (HP:0100764)2.75734551
33Wormian bones (HP:0002645)2.75620888
34Abnormality of skeletal muscle fiber size (HP:0012084)2.73116734
35Aortic aneurysm (HP:0004942)2.72966555
36Fat malabsorption (HP:0002630)2.70147324
37Cupped ribs (HP:0000887)2.64948353
38Osteolytic defects of the hand bones (HP:0009699)2.62513196
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.62513196
40Malnutrition (HP:0004395)2.60899061
41Shallow orbits (HP:0000586)2.59507302
42Wide cranial sutures (HP:0010537)2.58971782
43Aortic dissection (HP:0002647)2.58834031
44Ileus (HP:0002595)2.58644986
45Premature rupture of membranes (HP:0001788)2.57045048
46Gastrointestinal infarctions (HP:0005244)2.56637611
47Broad metatarsal (HP:0001783)2.55649362
48Gingivitis (HP:0000230)2.52138359
49Orchitis (HP:0100796)2.50590851
50Xanthomatosis (HP:0000991)2.49602928
51Focal segmental glomerulosclerosis (HP:0000097)2.49198848
52Abnormality of the 2nd finger (HP:0004100)2.49189457
53Wide anterior fontanel (HP:0000260)2.44522129
54Right ventricular cardiomyopathy (HP:0011663)2.43894729
55T lymphocytopenia (HP:0005403)2.43761684
56Acanthocytosis (HP:0001927)2.41034950
57Hyperextensible skin (HP:0000974)2.38530772
58Spinal rigidity (HP:0003306)2.36945155
59Biconcave vertebral bodies (HP:0004586)2.36354149
60Intrahepatic cholestasis (HP:0001406)2.36329515
61Turricephaly (HP:0000262)2.36109179
62Myositis (HP:0100614)2.31336404
63Short 4th metacarpal (HP:0010044)2.30787767
64Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.30787767
65Joint laxity (HP:0001388)2.30663697
66Cellulitis (HP:0100658)2.29168855
67Increased connective tissue (HP:0009025)2.28857468
68Abnormality of monocarboxylic acid metabolism (HP:0010996)2.28469829
69Abnormality of chloride homeostasis (HP:0011422)2.27938910
70Hypolipoproteinemia (HP:0010981)2.27831696
71Abnormality of T cell number (HP:0011839)2.26057341
72Ulnar bowing (HP:0003031)2.23821683
73Abnormality of purine metabolism (HP:0004352)2.21729965
74Spondylolisthesis (HP:0003302)2.21145238
75Cardiovascular calcification (HP:0011915)2.19293555
76Spontaneous hematomas (HP:0007420)2.18920412
77Abnormality of sulfur amino acid metabolism (HP:0004339)2.17070261
78Conjugated hyperbilirubinemia (HP:0002908)2.16838736
79Glomerulosclerosis (HP:0000096)2.16210098
80Abnormality of the peritoneum (HP:0002585)2.15329925
81Hyperactive renin-angiotensin system (HP:0000841)2.14795684
82Proximal tubulopathy (HP:0000114)2.13569523
83Chronic diarrhea (HP:0002028)2.12398974
84Aplasia involving bones of the upper limbs (HP:0009823)2.12351706
85Aplasia of the phalanges of the hand (HP:0009802)2.12351706
86Aplasia involving bones of the extremities (HP:0009825)2.12351706
87Mildly elevated creatine phosphokinase (HP:0008180)2.09448036
88Cerebral aneurysm (HP:0004944)2.09396939
89Abnormality of the phalanges of the 2nd finger (HP:0009541)2.08878000
90Mitral valve prolapse (HP:0001634)2.08776988
91Emphysema (HP:0002097)2.08408791
92Pigmentary retinal degeneration (HP:0001146)2.07571655
93Recurrent fungal infections (HP:0002841)2.06859280
94Delayed closure of the anterior fontanelle (HP:0001476)2.04753515
95Cervical subluxation (HP:0003308)2.04634310
96Autoimmune thrombocytopenia (HP:0001973)2.04195797
97Coronal craniosynostosis (HP:0004440)2.03826797
98Deep venous thrombosis (HP:0002625)2.01181147
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99724193
100Recurrent abscess formation (HP:0002722)1.98107680
101Abdominal distention (HP:0003270)1.97414003
102Gout (HP:0001997)1.96769799
103Hypoplasia of the thymus (HP:0000778)1.95397886
104Hypoplasia of the uterus (HP:0000013)1.95090757
105Hyperammonemia (HP:0001987)1.94634135
106Fragile skin (HP:0001030)1.94170308
107Abnormality of the middle phalanges of the toes (HP:0010183)1.93858541
108Short hallux (HP:0010109)1.91703311
109Aneurysm (HP:0002617)1.90513551
110Obstructive sleep apnea (HP:0002870)1.89504504
111Vascular calcification (HP:0004934)1.89319947
112Hypoplastic labia majora (HP:0000059)1.88747823
113Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.88434424
114Ketoacidosis (HP:0001993)1.86694494
115Bowel diverticulosis (HP:0005222)1.86467003
116Neonatal short-limb short stature (HP:0008921)1.85870942
117Knee flexion contracture (HP:0006380)1.85588014
118Persistence of primary teeth (HP:0006335)1.84454043
119Hypoplastic ischia (HP:0003175)1.83432297
120Abnormality of skull ossification (HP:0002703)1.83029189
121Retrobulbar optic neuritis (HP:0100654)1.82939484
122Optic neuritis (HP:0100653)1.82939484
123Disproportionate tall stature (HP:0001519)1.82128610
124Abnormality of the 4th metacarpal (HP:0010012)1.80519538
125Recurrent bacterial skin infections (HP:0005406)1.80396658
126Abnormality of macrophages (HP:0004311)1.79423859
127Gingival bleeding (HP:0000225)1.78971167
128Follicular hyperkeratosis (HP:0007502)1.78704104
129Mitral stenosis (HP:0001718)1.77675677
130Ketosis (HP:0001946)1.77151281
131Polycythemia (HP:0001901)1.76510031
132Hepatoblastoma (HP:0002884)1.76282478
133Alopecia of scalp (HP:0002293)1.75898581
134Shawl scrotum (HP:0000049)1.75861878
135Ectopia lentis (HP:0001083)1.75169979
136Aplasia/Hypoplasia of the hallux (HP:0008362)1.74515131
137Tibial bowing (HP:0002982)1.74490668
138Biliary tract neoplasm (HP:0100574)1.74202164
139Ovoid vertebral bodies (HP:0003300)1.73834735
140Mitral regurgitation (HP:0001653)1.73308270
141Striae distensae (HP:0001065)1.73215150
142Epidermoid cyst (HP:0200040)1.72559110
143Bell-shaped thorax (HP:0001591)1.72494335
144Dehydration (HP:0001944)1.72298057
145Redundant skin (HP:0001582)1.71835836
146Eosinophilia (HP:0001880)1.71832769
147Abnormality of the ischium (HP:0003174)1.71270988
148Abnormality of dentin (HP:0010299)1.71173194
149Neonatal hypoglycemia (HP:0001998)1.71156141
150Spastic diplegia (HP:0001264)1.70989003
151Long toe (HP:0010511)1.70683129
152Subcapsular cataract (HP:0000523)1.69513155
153Hypoproteinemia (HP:0003075)1.69444667
154Aortic regurgitation (HP:0001659)1.69425347
155Nephrolithiasis (HP:0000787)1.69106854
156Subacute progressive viral hepatitis (HP:0006572)1.68728008
157Abnormal cartilage morphology (HP:0002763)1.67578736
158Hyperuricemia (HP:0002149)1.67202531
159Increased purine levels (HP:0004368)1.67202531
160Cutaneous finger syndactyly (HP:0010554)1.67137280
161Abnormality of nucleobase metabolism (HP:0010932)1.67105863
162Nonimmune hydrops fetalis (HP:0001790)1.66965196
163Hypoplastic nipples (HP:0002557)1.66890812
164Thoracolumbar scoliosis (HP:0002944)1.66155163
165Hyperglycinemia (HP:0002154)1.65474653
166Elbow flexion contracture (HP:0002987)1.64424553
167Abnormal glucose tolerance (HP:0001952)1.63526292
168Myocardial infarction (HP:0001658)1.62685950
169Severe short stature (HP:0003510)1.61088545
170Abnormality of the acetabulum (HP:0003170)1.60122894
171Chondrocalcinosis (HP:0000934)1.58695422
172Abnormal delivery (HP:0001787)1.57801283
173Syringomyelia (HP:0003396)1.57457226
174Spinal cord lesions (HP:0100561)1.57457226

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.48466264
2LATS14.40591372
3STK393.70603642
4AKT33.61285540
5DDR23.33687021
6MST43.18216063
7SIK13.11879896
8OXSR13.00324085
9PRKD32.99218595
10EPHA22.86197056
11LMTK22.85584918
12MAP2K32.59792320
13PRKD22.20374275
14RIPK42.09780064
15RIPK12.01380421
16PDGFRA2.00189066
17EPHA31.95492967
18FER1.95339333
19ERN11.95131850
20TYK21.88451782
21MST1R1.79458252
22FGFR21.75705412
23EPHB21.72319347
24PTK61.71716921
25WNK41.67972426
26CDK121.66009072
27IRAK41.64967576
28CAMK1D1.59767696
29ACVR1B1.55369382
30MET1.55302642
31STK38L1.52817954
32STK31.51886472
33TRIB31.47170112
34KSR21.46152086
35BLK1.43044519
36TNK21.40667187
37SMG11.37306454
38MAP3K61.35889782
39NUAK11.34579665
40BCKDK1.32151423
41PRPF4B1.28718521
42MAP3K21.27077914
43PDK21.20929686
44ZAP701.17486501
45CSK1.16188491
46JAK31.15854076
47SCYL21.12892483
48CDC42BPA1.12434714
49LATS21.11856671
50WNK31.11479398
51MAP3K131.11265593
52PDK41.11223453
53PDK31.11223453
54KIT1.08653177
55TTN1.07447559
56MAP3K11.05840702
57PAK41.01660100
58LRRK21.01181408
59PTK20.98085626
60TAOK10.97077633
61YES10.95842488
62CAMK1G0.94615713
63TGFBR20.94281204
64TEC0.93689125
65NLK0.91068164
66SGK20.87988050
67STK100.87660119
68ICK0.86891245
69WNK10.84785020
70FGFR10.84615281
71ERBB20.83790051
72HCK0.82340752
73CDK60.81377165
74BTK0.81273388
75TAOK30.80875808
76PRKG20.80781050
77MOS0.80608993
78PIK3CA0.80248266
79BMX0.79329143
80MAP3K100.75739378
81MYLK0.73474818
82INSRR0.73302570
83MTOR0.73173916
84FGFR40.71404451
85PDGFRB0.70329963
86MAP3K70.68853125
87PKN20.68591742
88IRAK10.67814927
89DYRK1B0.66592886
90RPS6KA20.65786676
91MAPK70.65692686
92MARK20.65411476
93TBK10.64611658
94NEK90.63688595
95PRKAA20.62925512
96FGFR30.62165918
97PRKCH0.61997676
98PAK20.61994500
99MAP2K40.61056400
100PDK10.61029558
101HIPK20.59547319
102MAP4K10.58258482
103GRK10.57680254
104RPS6KL10.57312036
105RPS6KC10.57312036
106MAP3K140.56415439
107EPHB10.55832128
108SGK30.54070692
109MAP3K110.53858499
110PRKCI0.53457599
111MAP3K50.52433865
112GSK3A0.52387874
113EEF2K0.52030321
114PTK2B0.51760054
115IRAK20.51713669
116ROCK10.50689722
117LYN0.50594789
118STK380.49714374
119JAK10.49134467
120IKBKE0.48127959
121SYK0.45571807
122GRK50.45445783
123TYRO30.45138529
124DMPK0.45083420
125RPS6KA60.44595224
126TAOK20.44564106
127PRKAA10.38493637
128MAP3K80.37270730
129MAP2K10.36999864
130PAK30.36657439
131AKT20.34338770
132ERBB40.33344833
133CDK70.32544363
134INSR0.32223809
135PIK3CG0.31737994
136RET0.30883095
137MAP2K20.30304762
138NTRK10.30216819
139TRPM70.28301109
140NEK10.27492701
141PDPK10.26732138
142TTK0.26191099
143MELK0.25422891
144MAP3K30.23984223
145SRC0.23736043
146GRK60.22650767
147IGF1R0.19595438
148TESK10.19155651
149PRKCZ0.18826915
150MAPK110.18408124
151EGFR0.18326774
152JAK20.17389325
153PRKD10.16944535

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049753.01022216
2* Renin-angiotensin system_Homo sapiens_hsa046142.61284334
3Vitamin digestion and absorption_Homo sapiens_hsa049772.51333415
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.41567530
5Fatty acid degradation_Homo sapiens_hsa000712.38931822
6Nitrogen metabolism_Homo sapiens_hsa009102.31725623
7Mineral absorption_Homo sapiens_hsa049782.27206376
8Sulfur metabolism_Homo sapiens_hsa009202.22262932
9* Protein digestion and absorption_Homo sapiens_hsa049742.14746405
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14614060
11PPAR signaling pathway_Homo sapiens_hsa033202.12160786
12Tryptophan metabolism_Homo sapiens_hsa003802.06091839
13Starch and sucrose metabolism_Homo sapiens_hsa005002.04158263
14Propanoate metabolism_Homo sapiens_hsa006402.03994598
15Caffeine metabolism_Homo sapiens_hsa002321.98915754
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97239963
17Arginine biosynthesis_Homo sapiens_hsa002201.90343070
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89599613
19Bile secretion_Homo sapiens_hsa049761.85184696
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.80634879
21Fatty acid metabolism_Homo sapiens_hsa012121.76538045
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69438781
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.64583859
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.63666083
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63230382
26ECM-receptor interaction_Homo sapiens_hsa045121.52450675
27Osteoclast differentiation_Homo sapiens_hsa043801.48559021
28Histidine metabolism_Homo sapiens_hsa003401.44291171
29beta-Alanine metabolism_Homo sapiens_hsa004101.40829593
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37158564
31Pyruvate metabolism_Homo sapiens_hsa006201.36897269
32Butanoate metabolism_Homo sapiens_hsa006501.36704801
33Fatty acid biosynthesis_Homo sapiens_hsa000611.34207308
34Lysine degradation_Homo sapiens_hsa003101.33772558
35Leishmaniasis_Homo sapiens_hsa051401.32619035
36B cell receptor signaling pathway_Homo sapiens_hsa046621.31343725
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30697156
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27456887
39Malaria_Homo sapiens_hsa051441.25067380
40Peroxisome_Homo sapiens_hsa041461.24750109
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20279798
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20236522
43Galactose metabolism_Homo sapiens_hsa000521.18855337
44Selenocompound metabolism_Homo sapiens_hsa004501.16489507
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16390654
46Folate biosynthesis_Homo sapiens_hsa007901.15732023
47Adherens junction_Homo sapiens_hsa045201.15606676
48Acute myeloid leukemia_Homo sapiens_hsa052211.15385714
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14529669
50Staphylococcus aureus infection_Homo sapiens_hsa051501.13090588
51Non-small cell lung cancer_Homo sapiens_hsa052231.11475062
52Hepatitis C_Homo sapiens_hsa051601.10242254
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09878758
54Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09634777
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.09271555
56Glycerolipid metabolism_Homo sapiens_hsa005611.09115882
57Chronic myeloid leukemia_Homo sapiens_hsa052201.05767628
58Toxoplasmosis_Homo sapiens_hsa051451.04933546
59ABC transporters_Homo sapiens_hsa020101.04117127
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03190910
61Arginine and proline metabolism_Homo sapiens_hsa003300.99758791
62Chemical carcinogenesis_Homo sapiens_hsa052040.98189178
63Carbon metabolism_Homo sapiens_hsa012000.97735101
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96602643
65FoxO signaling pathway_Homo sapiens_hsa040680.95833266
66Glutathione metabolism_Homo sapiens_hsa004800.95827702
67TNF signaling pathway_Homo sapiens_hsa046680.95653045
68Tuberculosis_Homo sapiens_hsa051520.95100794
69Other glycan degradation_Homo sapiens_hsa005110.91625743
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91523672
71Platelet activation_Homo sapiens_hsa046110.89026189
72Tight junction_Homo sapiens_hsa045300.89015173
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87300866
74Pancreatic cancer_Homo sapiens_hsa052120.86596737
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86437716
76Focal adhesion_Homo sapiens_hsa045100.86057930
77Hippo signaling pathway_Homo sapiens_hsa043900.85755589
78Retinol metabolism_Homo sapiens_hsa008300.85483193
79Fructose and mannose metabolism_Homo sapiens_hsa000510.83275760
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82091055
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81235700
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80970274
83Influenza A_Homo sapiens_hsa051640.80790309
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79934357
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79408051
86Prolactin signaling pathway_Homo sapiens_hsa049170.79176480
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78757818
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.78204614
89Renal cell carcinoma_Homo sapiens_hsa052110.78140313
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77293517
91Basal cell carcinoma_Homo sapiens_hsa052170.76682522
92Thyroid hormone synthesis_Homo sapiens_hsa049180.76372192
93Measles_Homo sapiens_hsa051620.76030106
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.74596474
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.73240135
96Insulin signaling pathway_Homo sapiens_hsa049100.72632531
97Chemokine signaling pathway_Homo sapiens_hsa040620.72332537
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.71774546
99Complement and coagulation cascades_Homo sapiens_hsa046100.71623917
100Hepatitis B_Homo sapiens_hsa051610.71613905
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69681355
102Phagosome_Homo sapiens_hsa041450.68865643
103Amoebiasis_Homo sapiens_hsa051460.68617689
104Small cell lung cancer_Homo sapiens_hsa052220.68527478
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68522577
106Choline metabolism in cancer_Homo sapiens_hsa052310.67510452
107mTOR signaling pathway_Homo sapiens_hsa041500.67491166
108Bladder cancer_Homo sapiens_hsa052190.67162706
109Insulin resistance_Homo sapiens_hsa049310.65722342
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62462510
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62393686
112Biosynthesis of amino acids_Homo sapiens_hsa012300.61983391
113Arachidonic acid metabolism_Homo sapiens_hsa005900.61804829
114Glioma_Homo sapiens_hsa052140.59727381
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.59317198
116VEGF signaling pathway_Homo sapiens_hsa043700.58997342
117Legionellosis_Homo sapiens_hsa051340.58918088
118Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58674294
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.57078002
120Proteoglycans in cancer_Homo sapiens_hsa052050.56873339
121TGF-beta signaling pathway_Homo sapiens_hsa043500.56524604
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56352039
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.55784603
124GnRH signaling pathway_Homo sapiens_hsa049120.55596345
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.54401902
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52789472
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52676926
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.52620048
129Apoptosis_Homo sapiens_hsa042100.52140371
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50083960
131Phenylalanine metabolism_Homo sapiens_hsa003600.49875320
132Estrogen signaling pathway_Homo sapiens_hsa049150.49182216
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48462168
134Pertussis_Homo sapiens_hsa051330.47536750
135AMPK signaling pathway_Homo sapiens_hsa041520.47169937
136Prostate cancer_Homo sapiens_hsa052150.44998989
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.43576842
138Fatty acid elongation_Homo sapiens_hsa000620.42105144
139Hedgehog signaling pathway_Homo sapiens_hsa043400.39324515
140Thyroid cancer_Homo sapiens_hsa052160.38489444
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.37340222
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37107025
143Sphingolipid metabolism_Homo sapiens_hsa006000.37062729
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36850391
145Endometrial cancer_Homo sapiens_hsa052130.33969802
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.33866578
147Tyrosine metabolism_Homo sapiens_hsa003500.32174083
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.27683516
149PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26224896
150MicroRNAs in cancer_Homo sapiens_hsa052060.23127590
151Melanoma_Homo sapiens_hsa052180.22671524
152Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22599009

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