MMGT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.53154398
2mitotic sister chromatid cohesion (GO:0007064)5.31725272
3pyrimidine nucleobase catabolic process (GO:0006208)5.29878121
4regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.03595692
5nuclear pore complex assembly (GO:0051292)4.89989661
6metaphase plate congression (GO:0051310)4.72819780
7nuclear pore organization (GO:0006999)4.67614504
8establishment of chromosome localization (GO:0051303)4.63802437
9protein localization to chromosome, centromeric region (GO:0071459)4.42818727
10protein localization to kinetochore (GO:0034501)4.41074443
11ribosome assembly (GO:0042255)4.29888270
12establishment of integrated proviral latency (GO:0075713)4.21048291
13long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.09118868
14protein localization to microtubule (GO:0035372)4.02379349
15fatty acid elongation (GO:0030497)3.93685172
16acyl-CoA biosynthetic process (GO:0071616)3.91358302
17thioester biosynthetic process (GO:0035384)3.91358302
18fatty-acyl-CoA biosynthetic process (GO:0046949)3.90992727
19nucleobase catabolic process (GO:0046113)3.88302979
20CENP-A containing nucleosome assembly (GO:0034080)3.87031607
21central nervous system myelination (GO:0022010)3.86695307
22axon ensheathment in central nervous system (GO:0032291)3.86695307
23ribonucleoprotein complex disassembly (GO:0032988)3.85457667
24cullin deneddylation (GO:0010388)3.84009471
25chromatin remodeling at centromere (GO:0031055)3.67975737
26pore complex assembly (GO:0046931)3.64471346
27establishment of viral latency (GO:0019043)3.61545767
28mitotic chromosome condensation (GO:0007076)3.49030902
29protein deneddylation (GO:0000338)3.49003842
30long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.48480243
31COPI coating of Golgi vesicle (GO:0048205)3.46421132
32Golgi transport vesicle coating (GO:0048200)3.46421132
33protein localization to chromosome (GO:0034502)3.41497033
34establishment of nucleus localization (GO:0040023)3.39835318
35cholesterol biosynthetic process (GO:0006695)3.39116614
36neuron cell-cell adhesion (GO:0007158)3.34172816
37cellular ketone body metabolic process (GO:0046950)3.32443117
38fatty-acyl-CoA metabolic process (GO:0035337)3.31189084
39positive regulation of chromosome segregation (GO:0051984)3.28017011
40mitotic G2/M transition checkpoint (GO:0044818)3.25517730
41sister chromatid segregation (GO:0000819)3.24927090
42organelle disassembly (GO:1903008)3.24847956
43establishment of mitochondrion localization (GO:0051654)3.24623927
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.24488918
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.24488918
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.24488918
47negative regulation of axon extension involved in axon guidance (GO:0048843)3.22438464
48positive regulation of oligodendrocyte differentiation (GO:0048714)3.18928805
49lipid particle organization (GO:0034389)3.18491163
50tricarboxylic acid cycle (GO:0006099)3.16592440
51negative regulation of fibroblast apoptotic process (GO:2000270)3.16505495
52spindle checkpoint (GO:0031577)3.15598388
53attachment of spindle microtubules to kinetochore (GO:0008608)3.14784956
54DNA unwinding involved in DNA replication (GO:0006268)3.14179031
55negative regulation of axon guidance (GO:1902668)3.09385932
56dendrite morphogenesis (GO:0048813)3.08240695
57DNA replication-independent nucleosome assembly (GO:0006336)3.07967462
58DNA replication-independent nucleosome organization (GO:0034724)3.07967462
59mitotic sister chromatid segregation (GO:0000070)3.07682969
60IMP biosynthetic process (GO:0006188)3.07300757
61response to X-ray (GO:0010165)3.05367933
62lysine metabolic process (GO:0006553)3.03474975
63lysine catabolic process (GO:0006554)3.03474975
64regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.02551248
65regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00214564
66regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00214564
67regulation of axon extension involved in axon guidance (GO:0048841)2.96277042
68dendritic spine morphogenesis (GO:0060997)2.96068200
69ketone body metabolic process (GO:1902224)2.95721744
70negative regulation of microtubule polymerization (GO:0031115)2.95610307
71histamine secretion (GO:0001821)2.92970737
72ganglion development (GO:0061548)2.92434871
73cerebral cortex radially oriented cell migration (GO:0021799)2.92296743
74regulation of axon guidance (GO:1902667)2.90909101
75alpha-linolenic acid metabolic process (GO:0036109)2.90667606
76regulation of DNA endoreduplication (GO:0032875)2.90506472
77sensory perception of smell (GO:0007608)2.90422289
78regulation of chromosome segregation (GO:0051983)2.90312194
79sterol biosynthetic process (GO:0016126)2.89034676
80regulation of spindle organization (GO:0090224)2.88367345
81response to pheromone (GO:0019236)2.87475398
82acetyl-CoA metabolic process (GO:0006084)2.86188324
83ER overload response (GO:0006983)2.86110421
84kinetochore organization (GO:0051383)2.86104186
85negative regulation of DNA recombination (GO:0045910)2.85772307
86mitotic spindle checkpoint (GO:0071174)2.85608294
87myelin maintenance (GO:0043217)2.84637473
88apical protein localization (GO:0045176)2.81523862
89neuroblast proliferation (GO:0007405)2.81410786
90regulation of synapse structural plasticity (GO:0051823)2.80209884
91deoxyribonucleotide biosynthetic process (GO:0009263)2.77705479
92regulation of DNA methylation (GO:0044030)2.76821191
93regulation of acyl-CoA biosynthetic process (GO:0050812)2.76484335
94neuron recognition (GO:0008038)2.75425271
95histone exchange (GO:0043486)2.74554646
96spindle assembly checkpoint (GO:0071173)2.73666679
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73571230
98histone H2A ubiquitination (GO:0033522)2.73570558
99DNA strand elongation involved in DNA replication (GO:0006271)2.73415360
100presynaptic membrane assembly (GO:0097105)2.73380486
101cell migration in hindbrain (GO:0021535)2.73054706
102IMP metabolic process (GO:0046040)2.71650222
103biotin metabolic process (GO:0006768)2.71188379
104DNA strand elongation (GO:0022616)2.70819517
105mitotic nuclear envelope disassembly (GO:0007077)2.70273706
106regulation of cofactor metabolic process (GO:0051193)2.70269260
107regulation of coenzyme metabolic process (GO:0051196)2.70269260
108proteasome assembly (GO:0043248)2.69970062
109negative regulation of axon extension (GO:0030517)2.69106896
110regulation of sister chromatid segregation (GO:0033045)2.69042371
111regulation of mitotic sister chromatid separation (GO:0010965)2.69042371
112regulation of mitotic sister chromatid segregation (GO:0033047)2.69042371
113mitotic spindle organization (GO:0007052)2.68606542
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.67973117
115negative regulation of sister chromatid segregation (GO:0033046)2.67973117
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.67973117
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.67973117
118negative regulation of mitotic sister chromatid segregation (GO:0033048)2.67973117
119asymmetric protein localization (GO:0008105)2.67963939
120nuclear envelope disassembly (GO:0051081)2.66652289
121membrane disassembly (GO:0030397)2.66652289
122cellular protein complex localization (GO:0034629)2.66330134
123negative regulation of chromosome segregation (GO:0051985)2.65955732
124regulation of transforming growth factor beta2 production (GO:0032909)2.65327723
125positive regulation of cell size (GO:0045793)2.64996940
126COPII vesicle coating (GO:0048208)2.64270437
127substantia nigra development (GO:0021762)2.63830702
128protein heterotetramerization (GO:0051290)2.63183707
129axonal fasciculation (GO:0007413)2.62688913
130mitotic spindle assembly checkpoint (GO:0007094)2.61790974
131creatine metabolic process (GO:0006600)2.61224502
132phagocytosis, engulfment (GO:0006911)2.60968148
133negative regulation of axonogenesis (GO:0050771)2.60843794
134myelination (GO:0042552)2.60601943
135negative regulation of protein localization to plasma membrane (GO:1903077)2.59155539
136histone ubiquitination (GO:0016574)2.58839933
137axon ensheathment (GO:0008366)2.57314470
138ensheathment of neurons (GO:0007272)2.57314470
139negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.56851489
140mitotic G2 DNA damage checkpoint (GO:0007095)2.56615774
141inositol phosphate catabolic process (GO:0071545)2.55609852
142positive regulation of axon extension (GO:0045773)2.54485100
143regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.53665987
144acyl-CoA metabolic process (GO:0006637)2.53509888
145thioester metabolic process (GO:0035383)2.53509888
146clathrin coat assembly (GO:0048268)2.52980766
147nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.52371661
148positive regulation of actin filament depolymerization (GO:0030836)2.50796830
149triglyceride biosynthetic process (GO:0019432)2.50787295
150membrane invagination (GO:0010324)2.49640235
151purine nucleobase biosynthetic process (GO:0009113)2.49616815
152histone H2A acetylation (GO:0043968)2.49408276
153aspartate family amino acid catabolic process (GO:0009068)2.48745902
154ventricular cardiac muscle cell development (GO:0055015)2.48577161
155axon extension (GO:0048675)2.47186842
156phosphorylated carbohydrate dephosphorylation (GO:0046838)2.46825283
157inositol phosphate dephosphorylation (GO:0046855)2.46825283
158negative regulation of NF-kappaB import into nucleus (GO:0042347)2.46568754
159meiotic cell cycle (GO:0051321)2.46449908
160postreplication repair (GO:0006301)2.45897431
161neurotransmitter-gated ion channel clustering (GO:0072578)2.45400103
162establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.44680355
163mitochondrion transport along microtubule (GO:0047497)2.44680355
164protein K6-linked ubiquitination (GO:0085020)2.43864637
165cerebellar granule cell differentiation (GO:0021707)2.43158602
166positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.42563629
167folic acid transport (GO:0015884)2.41280052
168branched-chain amino acid catabolic process (GO:0009083)2.38150825
169regulation of extent of cell growth (GO:0061387)2.37475140
170long-chain fatty acid biosynthetic process (GO:0042759)2.37257051
171negative regulation of protein localization to cell surface (GO:2000009)2.36333755
172presynaptic membrane organization (GO:0097090)2.35929549
173organelle transport along microtubule (GO:0072384)2.35226816
174innervation (GO:0060384)2.35017141
175acylglycerol biosynthetic process (GO:0046463)2.32795624
176neutral lipid biosynthetic process (GO:0046460)2.32795624
177regulation of axon extension (GO:0030516)2.31198622
178membrane assembly (GO:0071709)2.29095526
179adipose tissue development (GO:0060612)2.27129934
180actin filament depolymerization (GO:0030042)2.26596501
181retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.26317103
182negative regulation of sodium ion transport (GO:0010766)2.26145845
183glutamate secretion (GO:0014047)2.25796430
184vesicle coating (GO:0006901)2.25699518
185very long-chain fatty acid metabolic process (GO:0000038)2.24191861
186protein localization to endosome (GO:0036010)2.22626338
187positive regulation of protein depolymerization (GO:1901881)2.22509330
188chondrocyte development (GO:0002063)2.21431907
189short-chain fatty acid metabolic process (GO:0046459)2.18011796
190negative regulation of potassium ion transmembrane transport (GO:1901380)2.16966354
191neuron projection extension (GO:1990138)2.16014081
192regulation of oligodendrocyte differentiation (GO:0048713)2.15560658
193regulation of synaptic vesicle exocytosis (GO:2000300)2.14815368
194myotube differentiation (GO:0014902)2.14680037
195auditory behavior (GO:0031223)2.14175572
196protein insertion into membrane (GO:0051205)2.13699085

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.48049472
2GBX2_23144817_ChIP-Seq_PC3_Human3.98203828
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.73048755
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.20028754
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14954373
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81369436
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.77791759
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.72171390
9PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.64164147
10SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.54440694
11AR_21572438_ChIP-Seq_LNCaP_Human2.50670029
12ELK1_19687146_ChIP-ChIP_HELA_Human2.47507563
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40543952
14OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.31332675
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31321789
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29732108
17TAF15_26573619_Chip-Seq_HEK293_Human2.26800415
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.25697247
19CLOCK_20551151_ChIP-Seq_293T_Human2.12098855
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.11490093
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.09971577
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.08854272
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.08599456
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04040152
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.03000740
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.95868204
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94883471
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94252811
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92746253
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90152865
31EZH2_22144423_ChIP-Seq_EOC_Human1.88959642
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86064414
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85546972
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.83141422
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.82943926
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.81010238
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.81010238
38ZNF274_21170338_ChIP-Seq_K562_Hela1.80823866
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76480148
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.75751956
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.71175672
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.70853821
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70426927
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69059040
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67805090
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.67583105
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63991781
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.63924090
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63503752
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62452735
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62335971
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61304107
53ER_23166858_ChIP-Seq_MCF-7_Human1.61084336
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60858190
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60858190
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60858190
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60755038
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.59465223
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57421792
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.57142780
61DCP1A_22483619_ChIP-Seq_HELA_Human1.56773848
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.56155481
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55496183
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55319925
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.54843580
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54761020
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.54299510
68MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53621374
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52494912
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52393144
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51952745
72AHR_22903824_ChIP-Seq_MCF-7_Human1.51495937
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49437020
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46979474
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.46426160
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.46186961
77P300_19829295_ChIP-Seq_ESCs_Human1.46137263
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44827643
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44250519
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43932741
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43932741
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.43263610
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43161027
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.42478326
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42124411
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41741652
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41589829
88TFEB_21752829_ChIP-Seq_HELA_Human1.41535356
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41222982
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41188145
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.39494314
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38349496
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37841193
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.35801924
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34704329
96MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33598575
97FUS_26573619_Chip-Seq_HEK293_Human1.32009416
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.31172751
99STAT3_23295773_ChIP-Seq_U87_Human1.30868891
100JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29549640
101VDR_23849224_ChIP-Seq_CD4+_Human1.28965574
102SMAD4_21799915_ChIP-Seq_A2780_Human1.27989387
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25552335
104CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25472746
105SALL1_21062744_ChIP-ChIP_HESCs_Human1.24836084
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24313040
107CJUN_26792858_Chip-Seq_BT549_Human1.23911707
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23503682
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23102406
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23046473
111E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21727528
112RNF2_27304074_Chip-Seq_ESCs_Mouse1.21372781
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20972320
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18125897
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16998564
116EZH2_27294783_Chip-Seq_ESCs_Mouse1.16633850
117DROSHA_22980978_ChIP-Seq_HELA_Human1.16441210
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15591140
119RARB_27405468_Chip-Seq_BRAIN_Mouse1.14730465
120THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13705258
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12376057
122ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12209212
123BRD4_25478319_ChIP-Seq_HGPS_Human1.10520868
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08650727
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08647862
126* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07903456
127EWS_26573619_Chip-Seq_HEK293_Human1.06976082
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06668720
129SOX9_26525672_Chip-Seq_HEART_Mouse1.05859188
130REST_21632747_ChIP-Seq_MESCs_Mouse1.05092911
131JUN_21703547_ChIP-Seq_K562_Human1.04969360
132CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04968546
133HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03699452
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03191116
135FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02546201
136SOX17_20123909_ChIP-Seq_XEN_Mouse1.01984912
137SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01788316
138GATA4_21415370_ChIP-Seq_HL-1_Mouse1.01785274
139FOXP3_21729870_ChIP-Seq_TREG_Human1.00738132
140CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00693402
141FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00158819
142SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99628395
143MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99543846
144PRDM14_20953172_ChIP-Seq_ESCs_Human0.98989765
145TP53_18474530_ChIP-ChIP_U2OS_Human0.98678293
146YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98198796
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97955199
148AR_25329375_ChIP-Seq_VCAP_Human0.97725894
149REST_19997604_ChIP-ChIP_NEURONS_Mouse0.97488020
150AR_21909140_ChIP-Seq_LNCAP_Human0.96941886
151MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96158821
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96020698
153AR_19668381_ChIP-Seq_PC3_Human0.95277164
154ETS1_20019798_ChIP-Seq_JURKAT_Human0.94935990
155FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94875735
156RING1B_27294783_Chip-Seq_NPCs_Mouse0.94741060
157SMAD4_21741376_ChIP-Seq_EPCs_Human0.94611245
158HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94460346
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93965651
160SALL4_22934838_ChIP-ChIP_CD34+_Human0.93879918
161JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93784176
162EZH2_27294783_Chip-Seq_NPCs_Mouse0.93450297
163CBP_20019798_ChIP-Seq_JUKART_Human0.93150103
164IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93150103
165EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92789325
166PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92635100
167NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91838533
168TTF2_22483619_ChIP-Seq_HELA_Human0.91763042
169TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91682091
170MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91100532
171REST_18959480_ChIP-ChIP_MESCs_Mouse0.90966671
172ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89382982
173NANOG_18555785_Chip-Seq_ESCs_Mouse0.89111845
174ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88734071
175STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88536029
176ELK1_22589737_ChIP-Seq_MCF10A_Human0.88077978
177BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88015365
178EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84108517

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.73420785
2MP0001984_abnormal_olfaction3.26904033
3MP0010094_abnormal_chromosome_stability3.13238176
4MP0010234_abnormal_vibrissa_follicle3.12871080
5MP0002877_abnormal_melanocyte_morpholog3.10752052
6MP0008058_abnormal_DNA_repair3.01706968
7MP0003077_abnormal_cell_cycle2.88478051
8MP0008057_abnormal_DNA_replication2.85842228
9MP0003718_maternal_effect2.83649172
10MP0004957_abnormal_blastocyst_morpholog2.66363584
11MP0008932_abnormal_embryonic_tissue2.64736035
12MP0009697_abnormal_copulation2.63832362
13MP0003111_abnormal_nucleus_morphology2.55389130
14MP0008438_abnormal_cutaneous_collagen2.42162355
15MP0000778_abnormal_nervous_system2.39017773
16MP0001529_abnormal_vocalization2.32265019
17MP0010307_abnormal_tumor_latency2.30771742
18MP0001299_abnormal_eye_distance/2.27349340
19MP0003693_abnormal_embryo_hatching2.20261484
20MP0008007_abnormal_cellular_replicative2.05442250
21MP0004130_abnormal_muscle_cell2.04541694
22MP0004270_analgesia2.04034868
23MP0009780_abnormal_chondrocyte_physiolo1.96704607
24MP0003329_amyloid_beta_deposits1.91675753
25MP0000920_abnormal_myelination1.83708909
26MP0003221_abnormal_cardiomyocyte_apopto1.82467355
27MP0005248_abnormal_Harderian_gland1.71801186
28MP0004859_abnormal_synaptic_plasticity1.71409853
29MP0001730_embryonic_growth_arrest1.68408223
30MP0002139_abnormal_hepatobiliary_system1.68010832
31MP0000350_abnormal_cell_proliferation1.67808206
32MP0000537_abnormal_urethra_morphology1.60567747
33MP0003890_abnormal_embryonic-extraembry1.53966940
34MP0000751_myopathy1.53361563
35MP0005360_urolithiasis1.51684126
36MP0002734_abnormal_mechanical_nocicepti1.51573136
37MP0000372_irregular_coat_pigmentation1.50893223
38MP0001188_hyperpigmentation1.49957759
39MP0003880_abnormal_central_pattern1.49832296
40MP0001672_abnormal_embryogenesis/_devel1.47674078
41MP0005380_embryogenesis_phenotype1.47674078
42MP0003634_abnormal_glial_cell1.47315394
43MP0003566_abnormal_cell_adhesion1.45079472
44MP0000358_abnormal_cell_content/1.43926159
45MP0002184_abnormal_innervation1.36585855
46MP0003705_abnormal_hypodermis_morpholog1.34834058
47MP0001697_abnormal_embryo_size1.31385660
48MP0000534_abnormal_ureter_morphology1.30011202
49MP0003984_embryonic_growth_retardation1.29711468
50MP0010678_abnormal_skin_adnexa1.29455715
51MP0004215_abnormal_myocardial_fiber1.29001716
52MP0004197_abnormal_fetal_growth/weight/1.28938633
53MP0000013_abnormal_adipose_tissue1.28811209
54MP0004858_abnormal_nervous_system1.28581293
55MP0001177_atelectasis1.27588822
56MP0002084_abnormal_developmental_patter1.27523128
57MP0002088_abnormal_embryonic_growth/wei1.27068048
58MP0004043_abnormal_pH_regulation1.26741874
59MP0002063_abnormal_learning/memory/cond1.25806751
60MP0008260_abnormal_autophagy1.24923944
61MP0000747_muscle_weakness1.24077419
62MP0003635_abnormal_synaptic_transmissio1.23892441
63MP0000462_abnormal_digestive_system1.22838158
64MP0005384_cellular_phenotype1.21889097
65MP0002060_abnormal_skin_morphology1.18941143
66MP0002080_prenatal_lethality1.18656469
67MP0002796_impaired_skin_barrier1.18588194
68MP0003941_abnormal_skin_development1.16675291
69MP0005386_behavior/neurological_phenoty1.16466038
70MP0004924_abnormal_behavior1.16466038
71MP0004134_abnormal_chest_morphology1.16056308
72MP0003806_abnormal_nucleotide_metabolis1.15875040
73MP0003632_abnormal_nervous_system1.15572854
74MP0005621_abnormal_cell_physiology1.14855511
75MP0002837_dystrophic_cardiac_calcinosis1.14853547
76MP0006035_abnormal_mitochondrial_morpho1.14628127
77MP0002009_preneoplasia1.14569502
78MP0000003_abnormal_adipose_tissue1.14454304
79MP0006276_abnormal_autonomic_nervous1.14133457
80MP0003942_abnormal_urinary_system1.12582117
81MP0004811_abnormal_neuron_physiology1.12560363
82MP0009053_abnormal_anal_canal1.12350907
83MP0002085_abnormal_embryonic_tissue1.12205539
84MP0004742_abnormal_vestibular_system1.11938387
85MP0003950_abnormal_plasma_membrane1.11505486
86MP0001958_emphysema1.09751062
87MP0004233_abnormal_muscle_weight1.09529575
88MP0002896_abnormal_bone_mineralization1.09443440
89MP0009250_abnormal_appendicular_skeleto1.09208968
90MP0003755_abnormal_palate_morphology1.08660668
91MP0001486_abnormal_startle_reflex1.08248872
92MP0003186_abnormal_redox_activity1.07680382
93MP0002882_abnormal_neuron_morphology1.07167235
94MP0003690_abnormal_glial_cell1.06352894
95MP0000955_abnormal_spinal_cord1.06060138
96MP0001666_abnormal_nutrient_absorption1.05602018
97MP0005395_other_phenotype1.05464858
98MP0002086_abnormal_extraembryonic_tissu1.04230698
99MP0002972_abnormal_cardiac_muscle1.02974393
100MP0004087_abnormal_muscle_fiber1.01646515
101MP0005620_abnormal_muscle_contractility1.01645925
102MP0008789_abnormal_olfactory_epithelium1.01539060
103MP0002067_abnormal_sensory_capabilities1.01267844
104MP0004272_abnormal_basement_membrane1.01133581
105MP0003935_abnormal_craniofacial_develop1.00353018
106MP0001727_abnormal_embryo_implantation0.99547542
107MP0004084_abnormal_cardiac_muscle0.99206882
108MP0000647_abnormal_sebaceous_gland0.98793776
109MP0002152_abnormal_brain_morphology0.98022564
110MP0004885_abnormal_endolymph0.97665481
111MP0002064_seizures0.97404484
112MP0004145_abnormal_muscle_electrophysio0.95978998
113MP0000313_abnormal_cell_death0.95832055
114MP0002736_abnormal_nociception_after0.95825481
115MP0005187_abnormal_penis_morphology0.95622289
116MP0002272_abnormal_nervous_system0.94944253
117MP0004185_abnormal_adipocyte_glucose0.94067497
118MP0000383_abnormal_hair_follicle0.93666152
119MP0009703_decreased_birth_body0.93602715
120MP0005058_abnormal_lysosome_morphology0.92764403
121MP0001915_intracranial_hemorrhage0.92483900
122MP0000569_abnormal_digit_pigmentation0.92320545
123MP0002066_abnormal_motor_capabilities/c0.91938253
124MP0005394_taste/olfaction_phenotype0.90969522
125MP0005499_abnormal_olfactory_system0.90969522
126MP0002735_abnormal_chemical_nociception0.90744161
127MP0004484_altered_response_of0.90010613
128MP0010030_abnormal_orbit_morphology0.90006272
129MP0005275_abnormal_skin_tensile0.89978551
130MP0005220_abnormal_exocrine_pancreas0.89171370
131MP0003385_abnormal_body_wall0.89011171
132MP0003137_abnormal_impulse_conducting0.88388318
133MP0005501_abnormal_skin_physiology0.87043858
134MP0002282_abnormal_trachea_morphology0.86643874
135MP0009672_abnormal_birth_weight0.86306314
136MP0003786_premature_aging0.86139575
137MP0001853_heart_inflammation0.85847507
138MP0002733_abnormal_thermal_nociception0.85175200
139MP0005623_abnormal_meninges_morphology0.84994070
140MP0005503_abnormal_tendon_morphology0.84962780
141MP0005365_abnormal_bile_salt0.84313503
142MP0001216_abnormal_epidermal_layer0.84188650
143MP0003861_abnormal_nervous_system0.84126965
144MP0001485_abnormal_pinna_reflex0.82071814
145MP0000604_amyloidosis0.81630166
146MP0000566_synostosis0.81530047
147MP0003937_abnormal_limbs/digits/tail_de0.81369669
148MP0004036_abnormal_muscle_relaxation0.81332370
149MP0001191_abnormal_skin_condition0.80928284
150MP0000749_muscle_degeneration0.80767379
151MP0003122_maternal_imprinting0.80590255
152MP0001661_extended_life_span0.80153032
153MP0004782_abnormal_surfactant_physiolog0.79956911
154MP0003453_abnormal_keratinocyte_physiol0.79902627
155MP0002090_abnormal_vision0.79546783
156MP0002557_abnormal_social/conspecific_i0.79397640
157MP0000427_abnormal_hair_cycle0.78552435
158MP0000759_abnormal_skeletal_muscle0.78404356
159MP0002928_abnormal_bile_duct0.78079469
160MP0005171_absent_coat_pigmentation0.78066342
161MP0002229_neurodegeneration0.77960629
162MP0004085_abnormal_heartbeat0.77827851
163MP0006054_spinal_hemorrhage0.77703166
164MP0002127_abnormal_cardiovascular_syste0.77696549
165MP0003567_abnormal_fetal_cardiomyocyte0.77582536
166MP0004808_abnormal_hematopoietic_stem0.77410093
167MP0002233_abnormal_nose_morphology0.76539946
168MP0003959_abnormal_lean_body0.75367792
169MP0000343_altered_response_to0.74004718
170MP0003656_abnormal_erythrocyte_physiolo0.72074898
171MP0001293_anophthalmia0.71582951
172MP0005076_abnormal_cell_differentiation0.71156459
173MP0003091_abnormal_cell_migration0.70027718
174MP0003300_gastrointestinal_ulcer0.69183449
175MP0005647_abnormal_sex_gland0.68371291
176MP0003448_altered_tumor_morphology0.68358306
177MP0010368_abnormal_lymphatic_system0.65782597
178MP0003123_paternal_imprinting0.64129322
179MP0003943_abnormal_hepatobiliary_system0.63434364
180MP0002163_abnormal_gland_morphology0.62262419
181MP0002177_abnormal_outer_ear0.62221795
182MP0008775_abnormal_heart_ventricle0.61206522

Predicted human phenotypes

RankGene SetZ-score
1Increased serum pyruvate (HP:0003542)4.55625631
2Abnormality of glycolysis (HP:0004366)4.55625631
3Insidious onset (HP:0003587)3.97301695
4Termporal pattern (HP:0011008)3.97301695
5Abnormality of the left ventricular outflow tract (HP:0011103)3.47625832
6Subaortic stenosis (HP:0001682)3.47625832
7Pheochromocytoma (HP:0002666)3.33268017
8Medulloblastoma (HP:0002885)3.12638674
9Disinhibition (HP:0000734)3.04833490
10Orthostatic hypotension (HP:0001278)3.04801611
11Rhabdomyosarcoma (HP:0002859)2.90870232
12Volvulus (HP:0002580)2.87974934
13Thyroid carcinoma (HP:0002890)2.80056093
14Premature rupture of membranes (HP:0001788)2.76257032
15Cortical dysplasia (HP:0002539)2.73779512
16Neuroendocrine neoplasm (HP:0100634)2.73025174
17Buphthalmos (HP:0000557)2.72070249
18Hypokinesia (HP:0002375)2.69569251
19Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.67958675
20Conjunctival hamartoma (HP:0100780)2.64530192
21Microglossia (HP:0000171)2.61945916
22Symptomatic seizures (HP:0011145)2.54316803
23Exercise-induced muscle cramps (HP:0003710)2.53557684
24Arterial tortuosity (HP:0005116)2.49944412
25Limb dystonia (HP:0002451)2.44647803
26Ankle clonus (HP:0011448)2.42165526
27Abnormal auditory evoked potentials (HP:0006958)2.41864267
28Glioma (HP:0009733)2.40616446
29Tetraparesis (HP:0002273)2.40314528
30Ketoacidosis (HP:0001993)2.40307238
31Abnormality of the corticospinal tract (HP:0002492)2.39250140
32Neoplasm of the adrenal gland (HP:0100631)2.38655388
33Facial hemangioma (HP:0000329)2.37518323
34Abnormality of glycine metabolism (HP:0010895)2.37461290
35Abnormality of serine family amino acid metabolism (HP:0010894)2.37461290
36Vascular tortuosity (HP:0004948)2.36083207
37Abnormal hair whorl (HP:0010721)2.34374489
38Prominent metopic ridge (HP:0005487)2.33176755
39Aqueductal stenosis (HP:0002410)2.31655153
40Apathy (HP:0000741)2.31605564
41Microvesicular hepatic steatosis (HP:0001414)2.29161440
42Spastic diplegia (HP:0001264)2.26652953
43Meningioma (HP:0002858)2.25311342
44Bladder neoplasm (HP:0009725)2.22875320
45Bladder carcinoma (HP:0002862)2.22875320
46Neoplasm of the peripheral nervous system (HP:0100007)2.22761636
47Hamartoma of the eye (HP:0010568)2.22682526
48Agnosia (HP:0010524)2.20704907
49Deep philtrum (HP:0002002)2.20168532
50Diminished motivation (HP:0000745)2.19801714
51Abnormality of methionine metabolism (HP:0010901)2.16238667
52Megalencephaly (HP:0001355)2.15414819
53Hypoglycemic seizures (HP:0002173)2.13375097
54Short middle phalanx of the 5th finger (HP:0004220)2.13113080
55Hypothermia (HP:0002045)2.11212841
56Abnormality of the metopic suture (HP:0005556)2.11112734
57Posterior subcapsular cataract (HP:0007787)2.09912846
58Exercise-induced myalgia (HP:0003738)2.09362759
59Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09011138
60Degeneration of the lateral corticospinal tracts (HP:0002314)2.09011138
61Overlapping toe (HP:0001845)2.08383492
62Cutaneous melanoma (HP:0012056)2.06013073
63Neurofibrillary tangles (HP:0002185)2.04087125
64Hyperglycinemia (HP:0002154)2.03579901
65Urinary urgency (HP:0000012)2.03080752
66Myoglobinuria (HP:0002913)2.01842870
67Abnormality of chromosome stability (HP:0003220)2.00287625
68Lymphangioma (HP:0100764)1.99699896
69Freckling (HP:0001480)1.99698705
70Loss of speech (HP:0002371)1.99625662
71Gout (HP:0001997)1.98931921
72Asymmetry of the thorax (HP:0001555)1.98522835
73Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96932408
74Cerebral inclusion bodies (HP:0100314)1.95283284
75Torticollis (HP:0000473)1.94577240
76Action tremor (HP:0002345)1.93542469
77Inappropriate behavior (HP:0000719)1.91089779
78Secondary amenorrhea (HP:0000869)1.90594316
79Anhidrosis (HP:0000970)1.88080355
80Transitional cell carcinoma of the bladder (HP:0006740)1.87560256
81Pachygyria (HP:0001302)1.86892555
82Hyperventilation (HP:0002883)1.86109523
83Anteriorly placed anus (HP:0001545)1.85909424
84Short tibia (HP:0005736)1.84176253
85Septate vagina (HP:0001153)1.83018878
86Back pain (HP:0003418)1.82912029
87Mutism (HP:0002300)1.82330103
88Excessive salivation (HP:0003781)1.81773647
89Drooling (HP:0002307)1.81773647
90Curly hair (HP:0002212)1.81077162
91Large earlobe (HP:0009748)1.80987349
92Ketosis (HP:0001946)1.80751501
93Abnormality of the fetal cardiovascular system (HP:0010948)1.78666168
94Abnormal umbilical cord blood vessels (HP:0011403)1.78666168
95Single umbilical artery (HP:0001195)1.78666168
96Cone-rod dystrophy (HP:0000548)1.78505286
97Abnormality of dentin (HP:0010299)1.78183044
98Generalized myoclonic seizures (HP:0002123)1.78002466
99Abnormality of the musculature of the pelvis (HP:0001469)1.77746119
100Abnormality of the hip-girdle musculature (HP:0001445)1.77746119
101Macroorchidism (HP:0000053)1.77388955
102Upper limb muscle weakness (HP:0003484)1.75782579
103Hypoplasia of the brainstem (HP:0002365)1.75584038
104Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75584038
105Palpitations (HP:0001962)1.75549988
106Postnatal microcephaly (HP:0005484)1.75053235
107Hyperinsulinemic hypoglycemia (HP:0000825)1.74869255
108Abnormality of fatty-acid metabolism (HP:0004359)1.74501240
109Neoplasm of striated muscle (HP:0009728)1.74381063
110Acute myeloid leukemia (HP:0004808)1.73576283
111Bundle branch block (HP:0011710)1.73091780
112Subacute progressive viral hepatitis (HP:0006572)1.72980426
113Neoplasm of the thyroid gland (HP:0100031)1.72197246
114Intention tremor (HP:0002080)1.72076223
115Shoulder girdle muscle weakness (HP:0003547)1.72044393
116Hypoglycemic coma (HP:0001325)1.71092192
117Spastic gait (HP:0002064)1.70796404
118Embryonal renal neoplasm (HP:0011794)1.70260381
119Supranuclear gaze palsy (HP:0000605)1.67123308
120Craniofacial dystonia (HP:0012179)1.66308549
121Hyporeflexia of lower limbs (HP:0002600)1.65073004
122Relative macrocephaly (HP:0004482)1.64461558
123Hyperglycinuria (HP:0003108)1.64110989
124Cavernous hemangioma (HP:0001048)1.63324170
125Nephroblastoma (Wilms tumor) (HP:0002667)1.62794282
126Increased nuchal translucency (HP:0010880)1.62767267
127Congenital glaucoma (HP:0001087)1.62744318
128Abnormal biliary tract morphology (HP:0012440)1.62612118
129Bifid tongue (HP:0010297)1.62578055
130Urethral obstruction (HP:0000796)1.62172532
131Ankle contracture (HP:0006466)1.61363256
132Progressive hearing impairment (HP:0001730)1.60976018
133Hammertoe (HP:0001765)1.60549832
134Abnormality of the septum pellucidum (HP:0007375)1.60482387
135Neoplasm of the oral cavity (HP:0100649)1.60319350
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.60126383
137Abnormality of alanine metabolism (HP:0010916)1.60126383
138Hyperalaninemia (HP:0003348)1.60126383
139Difficulty running (HP:0009046)1.59783683
140Polymicrogyria (HP:0002126)1.59677898
141Limb hypertonia (HP:0002509)1.58764053
142Abnormality of the astrocytes (HP:0100707)1.58133396
143Astrocytoma (HP:0009592)1.58133396
144Muscle fiber splitting (HP:0003555)1.57900384
145Akinesia (HP:0002304)1.57842110
146Lower limb muscle weakness (HP:0007340)1.57756657
147Synostosis involving the elbow (HP:0003938)1.57590511
148Humeroradial synostosis (HP:0003041)1.57590511
149Cortical visual impairment (HP:0100704)1.57555866
150Rimmed vacuoles (HP:0003805)1.57163916
151Median cleft lip (HP:0000161)1.57061057
152Central scotoma (HP:0000603)1.57055046
153Athetosis (HP:0002305)1.56740934
154Soft skin (HP:0000977)1.55801669
155Anosmia (HP:0000458)1.55705171
156Abnormal lung lobation (HP:0002101)1.54914369
157Coronal craniosynostosis (HP:0004440)1.54585360
158Clonus (HP:0002169)1.54582730
159Poor eye contact (HP:0000817)1.54304149
160Large hands (HP:0001176)1.54298123
161Papillary thyroid carcinoma (HP:0002895)1.53924053
162Hypoplastic pelvis (HP:0008839)1.53308172
163Abnormality of the umbilical cord (HP:0010881)1.53307367
164Shallow orbits (HP:0000586)1.53133600
165Spastic tetraplegia (HP:0002510)1.52896398
166Hyperthyroidism (HP:0000836)1.51379686
167Visceral angiomatosis (HP:0100761)1.51076063
168Myokymia (HP:0002411)1.50615801
169Focal dystonia (HP:0004373)1.49386604
170Hyperammonemia (HP:0001987)1.49151671
171Abnormality of pain sensation (HP:0010832)1.49115482
172Impaired pain sensation (HP:0007328)1.49115482
173Segmental peripheral demyelination/remyelination (HP:0003481)1.48908996
174Atonic seizures (HP:0010819)1.48435526
175Stridor (HP:0010307)1.48379385
176Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.48151641
177Limb-girdle muscle weakness (HP:0003325)1.47979178
178Nemaline bodies (HP:0003798)1.46556430
179Distal arthrogryposis (HP:0005684)1.46115454
180Foot dorsiflexor weakness (HP:0009027)1.46005719
181Hypokalemic alkalosis (HP:0001949)1.45308022
182Muscle fiber inclusion bodies (HP:0100299)1.45201264
183Autoamputation (HP:0001218)1.44738214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.15591742
2FGFR23.78392694
3MARK13.59393532
4TRIM283.48878723
5LIMK13.02337351
6EIF2AK13.00014929
7TTK2.89253225
8ERBB32.84844517
9STK392.72712925
10TNIK2.62198261
11FRK2.60922832
12BCR2.46703939
13PHKG12.46489028
14PHKG22.46489028
15NEK12.44318511
16MST42.39789585
17OXSR12.29221520
18CASK2.24979817
19TRIB32.24587843
20BUB12.15313571
21PAK31.89085632
22SRPK11.74347831
23MINK11.71882334
24MAP3K41.65956880
25STK38L1.65926829
26UHMK11.63933672
27DYRK21.57010900
28PBK1.53701571
29YES11.52877400
30WNK41.51347536
31PDGFRA1.48941916
32MAP3K141.47894013
33IRAK31.47705840
34WNK31.47277717
35WEE11.41748252
36MKNK11.38663729
37CSNK1G31.37137864
38TTN1.36735698
39CSNK1A1L1.36117074
40CSNK1G21.31915363
41MAP3K131.29908354
42KSR11.27584389
43BRSK21.27344183
44MAP4K21.26544667
45NTRK21.26162935
46BCKDK1.25495605
47PDK41.24685197
48PDK31.24685197
49EIF2AK21.24540064
50BRAF1.23254296
51ACVR1B1.20975473
52STK101.20929714
53FGFR11.19538505
54ILK1.17647135
55SGK4941.17518916
56SGK2231.17518916
57LATS11.16874123
58MAPK131.15886594
59MAP2K41.15098962
60CDK141.14809933
61CDK61.13483544
62TYRO31.09633191
63ERBB41.08357092
64CDC71.08316529
65CDK181.07750653
66STK241.02795635
67PLK11.02122344
68MKNK21.00153328
69PNCK0.98967051
70CDK150.97746224
71CSNK1G10.97037660
72PKN10.96929535
73CLK10.96342645
74PDK20.92950622
75PLK20.92763816
76PAK40.92753834
77PLK30.91993801
78NEK60.91137952
79PRPF4B0.90322277
80ARAF0.87620742
81STK160.86666406
82SIK10.86333264
83ROCK20.86175242
84BMPR1B0.84441254
85DDR20.84200131
86PLK40.84069460
87NUAK10.83864070
88PAK60.83589799
89MOS0.83287566
90WNK10.82419580
91SCYL20.80890040
92MST1R0.79816873
93BMPR20.79541674
94SIK30.79441062
95PDGFRB0.78243202
96NEK90.77690225
97CDK90.76134955
98NLK0.75885311
99MET0.75631015
100CAMK2B0.75211998
101LATS20.75160602
102RPS6KA40.73973575
103MELK0.73944281
104CDK11A0.73418884
105BRSK10.72525811
106EPHB10.71989207
107CDK50.71518343
108CCNB10.70054755
109RET0.69001146
110LMTK20.64231702
111TESK10.64023992
112PRKD30.63684054
113DMPK0.63426065
114NME10.62228866
115NTRK30.61368863
116MARK30.61076721
117PIK3CA0.60941559
118ROCK10.59497831
119CAMK2D0.58030904
120PKN20.57412778
121MAP3K50.57110179
122DYRK1B0.56820157
123PRKAA10.56533646
124FER0.56495996
125TESK20.56447393
126MAP3K120.56435046
127MAP2K70.55267543
128DYRK30.55228279
129MAP3K90.55208597
130PTK60.53204962
131ATM0.52056488
132MAP3K80.51642195
133NEK20.51104587
134OBSCN0.51087086
135ALK0.50502623
136BRD40.50121105
137IRAK10.48690099
138AURKB0.48554588
139CHEK20.48142094
140CHEK10.45278183
141MAPKAPK50.45150553
142TGFBR10.43917950
143FLT30.43526216
144TSSK60.42306232
145CAMK1G0.41038612
146RPS6KA20.40079463
147CAMK1D0.40019671
148NTRK10.39928665
149RAF10.38786439
150DAPK20.38076706
151ICK0.37655525
152PRKACB0.37106127
153INSRR0.36926065
154SGK20.36875498
155PTK20.36418080
156CDK120.36269940
157IRAK20.35821764
158KSR20.35040911
159PRKCZ0.34460162
160CAMK2A0.33180443
161STK30.32788997
162PRKCG0.32567379
163CDK30.31149014
164EGFR0.29608953
165CDK10.27293078

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.38534354
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.53522002
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.06600480
4Butanoate metabolism_Homo sapiens_hsa006502.87398604
5Steroid biosynthesis_Homo sapiens_hsa001002.77490264
6Propanoate metabolism_Homo sapiens_hsa006402.69920673
7Cell cycle_Homo sapiens_hsa041102.64336835
8Non-homologous end-joining_Homo sapiens_hsa034502.56014204
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55206725
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.51902870
11Fatty acid metabolism_Homo sapiens_hsa012122.45120897
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44596808
13Mismatch repair_Homo sapiens_hsa034302.43386133
14Proteasome_Homo sapiens_hsa030502.38559688
15Basal transcription factors_Homo sapiens_hsa030222.35774503
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33152583
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.30039924
18Fatty acid elongation_Homo sapiens_hsa000622.22568337
19RNA transport_Homo sapiens_hsa030132.11810190
20DNA replication_Homo sapiens_hsa030301.96406072
21Fatty acid degradation_Homo sapiens_hsa000711.91825320
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87483688
23mRNA surveillance pathway_Homo sapiens_hsa030151.72441858
24Pyruvate metabolism_Homo sapiens_hsa006201.72415323
25Olfactory transduction_Homo sapiens_hsa047401.70435445
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70145899
27Nucleotide excision repair_Homo sapiens_hsa034201.59927164
28Sulfur metabolism_Homo sapiens_hsa009201.59608493
29RNA degradation_Homo sapiens_hsa030181.58065785
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.57594316
31Shigellosis_Homo sapiens_hsa051311.51917638
32Circadian rhythm_Homo sapiens_hsa047101.48372345
33Fatty acid biosynthesis_Homo sapiens_hsa000611.44228957
34Legionellosis_Homo sapiens_hsa051341.41657226
35Nitrogen metabolism_Homo sapiens_hsa009101.40583162
36Axon guidance_Homo sapiens_hsa043601.36066677
37Carbon metabolism_Homo sapiens_hsa012001.34511284
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29102651
39Vitamin B6 metabolism_Homo sapiens_hsa007501.26557049
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25680049
41Base excision repair_Homo sapiens_hsa034101.19408119
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18081130
43p53 signaling pathway_Homo sapiens_hsa041151.14026074
44Adherens junction_Homo sapiens_hsa045201.14013844
45Folate biosynthesis_Homo sapiens_hsa007901.12684115
46Spliceosome_Homo sapiens_hsa030401.12256087
47Colorectal cancer_Homo sapiens_hsa052101.10288395
48PPAR signaling pathway_Homo sapiens_hsa033201.05432880
49Thyroid cancer_Homo sapiens_hsa052161.04766827
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96765375
51Peroxisome_Homo sapiens_hsa041460.96435070
52GABAergic synapse_Homo sapiens_hsa047270.95656922
53Tryptophan metabolism_Homo sapiens_hsa003800.95549189
54Dopaminergic synapse_Homo sapiens_hsa047280.94118197
55Pancreatic cancer_Homo sapiens_hsa052120.91539863
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90146653
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89745154
58MicroRNAs in cancer_Homo sapiens_hsa052060.89531590
59Pentose phosphate pathway_Homo sapiens_hsa000300.89116610
60Regulation of autophagy_Homo sapiens_hsa041400.86604574
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86169784
62AMPK signaling pathway_Homo sapiens_hsa041520.83642251
63Salmonella infection_Homo sapiens_hsa051320.83271350
64Biosynthesis of amino acids_Homo sapiens_hsa012300.82007655
65Vibrio cholerae infection_Homo sapiens_hsa051100.81313094
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80790774
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78309480
68Arginine and proline metabolism_Homo sapiens_hsa003300.77865813
69Tight junction_Homo sapiens_hsa045300.77591868
70Synaptic vesicle cycle_Homo sapiens_hsa047210.76969686
71Renal cell carcinoma_Homo sapiens_hsa052110.74455296
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.73592640
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72005733
74Galactose metabolism_Homo sapiens_hsa000520.71893358
75Hippo signaling pathway_Homo sapiens_hsa043900.71722359
76beta-Alanine metabolism_Homo sapiens_hsa004100.71710950
77Hepatitis B_Homo sapiens_hsa051610.71660225
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71001867
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70339737
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68169936
81Alcoholism_Homo sapiens_hsa050340.68076285
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68069387
83Gap junction_Homo sapiens_hsa045400.68066119
84Dilated cardiomyopathy_Homo sapiens_hsa054140.68038263
85FoxO signaling pathway_Homo sapiens_hsa040680.67824899
86Proteoglycans in cancer_Homo sapiens_hsa052050.67092443
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66057209
88Fanconi anemia pathway_Homo sapiens_hsa034600.65100527
89Long-term depression_Homo sapiens_hsa047300.64720266
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64689020
91Prostate cancer_Homo sapiens_hsa052150.64126447
92Endometrial cancer_Homo sapiens_hsa052130.61090256
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60793036
94Glioma_Homo sapiens_hsa052140.59398487
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59075253
96Sphingolipid metabolism_Homo sapiens_hsa006000.58673877
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58649044
98Insulin signaling pathway_Homo sapiens_hsa049100.58009061
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56738950
100Collecting duct acid secretion_Homo sapiens_hsa049660.55129196
101Lysosome_Homo sapiens_hsa041420.54821312
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53314913
103Pyrimidine metabolism_Homo sapiens_hsa002400.52383257
104RNA polymerase_Homo sapiens_hsa030200.52228317
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.51533225
106Phagosome_Homo sapiens_hsa041450.51509313
107Ether lipid metabolism_Homo sapiens_hsa005650.51236534
108Focal adhesion_Homo sapiens_hsa045100.51100899
109ErbB signaling pathway_Homo sapiens_hsa040120.50714083
110Arginine biosynthesis_Homo sapiens_hsa002200.49935493
111Inositol phosphate metabolism_Homo sapiens_hsa005620.49582432
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49351200
113N-Glycan biosynthesis_Homo sapiens_hsa005100.49073745
114Morphine addiction_Homo sapiens_hsa050320.48610508
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47826291
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47698228
117Chronic myeloid leukemia_Homo sapiens_hsa052200.46718987
118Protein export_Homo sapiens_hsa030600.46702698
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46633725
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46473723
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46286892
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.45989896
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.45893076
124Bile secretion_Homo sapiens_hsa049760.45318786
125Circadian entrainment_Homo sapiens_hsa047130.44782710
126Cholinergic synapse_Homo sapiens_hsa047250.44627815
127Glutamatergic synapse_Homo sapiens_hsa047240.44584660
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43823910
129Cocaine addiction_Homo sapiens_hsa050300.43553050
130Homologous recombination_Homo sapiens_hsa034400.42452570
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41945890
132Oocyte meiosis_Homo sapiens_hsa041140.41425818
133Insulin resistance_Homo sapiens_hsa049310.40626248
134Endocytosis_Homo sapiens_hsa041440.40311104
135Purine metabolism_Homo sapiens_hsa002300.39980346
136Wnt signaling pathway_Homo sapiens_hsa043100.39383450
137Vitamin digestion and absorption_Homo sapiens_hsa049770.38889949
138Cardiac muscle contraction_Homo sapiens_hsa042600.38707391
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38098901
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37488873
141Glucagon signaling pathway_Homo sapiens_hsa049220.37419569
142Serotonergic synapse_Homo sapiens_hsa047260.37381365
143Fat digestion and absorption_Homo sapiens_hsa049750.37376847
144Histidine metabolism_Homo sapiens_hsa003400.36264617
145TGF-beta signaling pathway_Homo sapiens_hsa043500.36204339
146Small cell lung cancer_Homo sapiens_hsa052220.36070626
147Insulin secretion_Homo sapiens_hsa049110.35730164
148Viral carcinogenesis_Homo sapiens_hsa052030.35600473
149HIF-1 signaling pathway_Homo sapiens_hsa040660.35207267
150Lysine degradation_Homo sapiens_hsa003100.35007841
151Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34844066
152Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34764069
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34497442
154Viral myocarditis_Homo sapiens_hsa054160.34400125
155Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34373768
156Amoebiasis_Homo sapiens_hsa051460.34267790
157Nicotine addiction_Homo sapiens_hsa050330.33903657
158Melanoma_Homo sapiens_hsa052180.32801826
159Maturity onset diabetes of the young_Homo sapiens_hsa049500.32735537
160mTOR signaling pathway_Homo sapiens_hsa041500.32376822
161PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31417599
162Starch and sucrose metabolism_Homo sapiens_hsa005000.30816030

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