Rank | Gene Set | Z-score |
---|---|---|
1 | wound healing, spreading of epidermal cells (GO:0035313) | 8.85034822 |
2 | blood vessel maturation (GO:0001955) | 7.88445959 |
3 | wound healing, spreading of cells (GO:0044319) | 6.10184628 |
4 | hemidesmosome assembly (GO:0031581) | 6.04852883 |
5 | endodermal cell differentiation (GO:0035987) | 5.99718528 |
6 | mesodermal cell differentiation (GO:0048333) | 5.89015992 |
7 | substrate-dependent cell migration (GO:0006929) | 5.51692214 |
8 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 5.03168873 |
9 | negative regulation of anoikis (GO:2000811) | 5.01602115 |
10 | skin morphogenesis (GO:0043589) | 4.81817404 |
11 | cell-substrate junction assembly (GO:0007044) | 4.68158238 |
12 | hyaluronan catabolic process (GO:0030214) | 4.64231432 |
13 | lymphangiogenesis (GO:0001946) | 4.61620303 |
14 | positive regulation of receptor recycling (GO:0001921) | 4.42901835 |
15 | hypotonic response (GO:0006971) | 4.29321327 |
16 | chondrocyte proliferation (GO:0035988) | 4.25589877 |
17 | protein localization to endosome (GO:0036010) | 4.19020537 |
18 | positive regulation of astrocyte differentiation (GO:0048711) | 4.12761831 |
19 | cellular response to vitamin D (GO:0071305) | 4.08887864 |
20 | regulation of anoikis (GO:2000209) | 4.04264264 |
21 | endothelium development (GO:0003158) | 4.02468845 |
22 | positive regulation of osteoblast proliferation (GO:0033690) | 4.01240671 |
23 | positive regulation of actin cytoskeleton reorganization (GO:2000251) | 3.85954243 |
24 | regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947) | 3.81100433 |
25 | positive regulation of blood vessel endothelial cell migration (GO:0043536) | 3.79689894 |
26 | sprouting angiogenesis (GO:0002040) | 3.77180131 |
27 | cell migration involved in sprouting angiogenesis (GO:0002042) | 3.71885211 |
28 | endothelial cell proliferation (GO:0001935) | 3.71797914 |
29 | positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949) | 3.65178344 |
30 | vascular endothelial growth factor receptor signaling pathway (GO:0048010) | 3.64924007 |
31 | negative regulation of focal adhesion assembly (GO:0051895) | 3.61511361 |
32 | negative regulation of cell junction assembly (GO:1901889) | 3.61511361 |
33 | negative regulation of adherens junction organization (GO:1903392) | 3.61511361 |
34 | angiogenesis involved in wound healing (GO:0060055) | 3.61287791 |
35 | COPI coating of Golgi vesicle (GO:0048205) | 3.56122034 |
36 | Golgi transport vesicle coating (GO:0048200) | 3.56122034 |
37 | endothelial cell morphogenesis (GO:0001886) | 3.50510844 |
38 | artery development (GO:0060840) | 3.49615816 |
39 | positive regulation of interleukin-8 secretion (GO:2000484) | 3.47499892 |
40 | negative regulation of blood vessel endothelial cell migration (GO:0043537) | 3.33009530 |
41 | heparan sulfate proteoglycan biosynthetic process (GO:0015012) | 3.32402591 |
42 | vascular endothelial growth factor signaling pathway (GO:0038084) | 3.30441803 |
43 | morphogenesis of an endothelium (GO:0003159) | 3.30385696 |
44 | endothelial tube morphogenesis (GO:0061154) | 3.30385696 |
45 | lung lobe morphogenesis (GO:0060463) | 3.27978913 |
46 | cellular response to vitamin (GO:0071295) | 3.25616592 |
47 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 3.25062912 |
48 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 3.17393636 |
49 | axon extension involved in axon guidance (GO:0048846) | 3.17393636 |
50 | heterotypic cell-cell adhesion (GO:0034113) | 3.13447734 |
51 | * collagen metabolic process (GO:0032963) | 3.10611527 |
52 | regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307) | 3.09344575 |
53 | * collagen catabolic process (GO:0030574) | 3.09344288 |
54 | venous blood vessel morphogenesis (GO:0048845) | 3.09323752 |
55 | * extracellular matrix disassembly (GO:0022617) | 3.08821255 |
56 | regulation of cell migration involved in sprouting angiogenesis (GO:0090049) | 3.08585088 |
57 | positive regulation of endothelial cell migration (GO:0010595) | 3.08025986 |
58 | renal filtration (GO:0097205) | 3.07238535 |
59 | regulation of blood vessel endothelial cell migration (GO:0043535) | 3.06374153 |
60 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 3.03925615 |
61 | ganglion development (GO:0061548) | 3.02566150 |
62 | blood vessel endothelial cell migration (GO:0043534) | 3.01619404 |
63 | positive regulation of epithelial cell migration (GO:0010634) | 3.00106329 |
64 | peptide catabolic process (GO:0043171) | 3.00100717 |
65 | basement membrane organization (GO:0071711) | 2.97705199 |
66 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 2.97044592 |
67 | semaphorin-plexin signaling pathway (GO:0071526) | 2.94846804 |
68 | endochondral ossification (GO:0001958) | 2.91315738 |
69 | replacement ossification (GO:0036075) | 2.91315738 |
70 | mammary gland epithelial cell proliferation (GO:0033598) | 2.91168116 |
71 | endothelial cell migration (GO:0043542) | 2.88445366 |
72 | stress fiber assembly (GO:0043149) | 2.87995147 |
73 | negative regulation of chondrocyte differentiation (GO:0032331) | 2.87252995 |
74 | negative regulation of nitric-oxide synthase activity (GO:0051001) | 2.85045698 |
75 | substrate adhesion-dependent cell spreading (GO:0034446) | 2.84965118 |
76 | * multicellular organismal macromolecule metabolic process (GO:0044259) | 2.84216863 |
77 | hepatocyte differentiation (GO:0070365) | 2.83942215 |
78 | regulation of actin cytoskeleton reorganization (GO:2000249) | 2.83703152 |
79 | regulation of collagen metabolic process (GO:0010712) | 2.83564198 |
80 | * multicellular organismal catabolic process (GO:0044243) | 2.83478422 |
81 | hormone catabolic process (GO:0042447) | 2.82782786 |
82 | endothelial cell chemotaxis (GO:0035767) | 2.80471594 |
83 | protein maturation by protein folding (GO:0022417) | 2.79348914 |
84 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.77998491 |
85 | angiogenesis (GO:0001525) | 2.77255426 |
86 | membrane protein ectodomain proteolysis (GO:0006509) | 2.74790840 |
87 | SMAD protein complex assembly (GO:0007183) | 2.72520123 |
88 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 2.70188879 |
89 | regulation of transforming growth factor beta1 production (GO:0032908) | 2.70143451 |
90 | * multicellular organismal metabolic process (GO:0044236) | 2.67115336 |
91 | regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043 | 2.66326595 |
92 | viral entry into host cell (GO:0046718) | 2.66234538 |
93 | regulation of positive chemotaxis (GO:0050926) | 2.65810249 |
94 | response to magnesium ion (GO:0032026) | 2.65065150 |
95 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241) | 2.65002935 |
96 | negative regulation of endothelial cell migration (GO:0010596) | 2.64589258 |
97 | negative regulation of platelet activation (GO:0010544) | 2.64512562 |
98 | positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862) | 2.63999464 |
99 | heparan sulfate proteoglycan metabolic process (GO:0030201) | 2.62413708 |
100 | cell adhesion mediated by integrin (GO:0033627) | 10.5704950 |
Rank | Gene Set | Z-score |
---|---|---|
1 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 3.95862596 |
2 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 3.58990699 |
3 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 3.36283206 |
4 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 3.23812035 |
5 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 3.08662920 |
6 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.99511173 |
7 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 2.98232484 |
8 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.89646073 |
9 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.86941747 |
10 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.68618148 |
11 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 2.68490029 |
12 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.67968436 |
13 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 2.27710782 |
14 | BRD4_25478319_ChIP-Seq_HGPS_Human | 2.27312007 |
15 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 2.16925802 |
16 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 2.16925802 |
17 | CJUN_26792858_Chip-Seq_BT549_Human | 2.08764235 |
18 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 2.01745501 |
19 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 10.1575139 |
20 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.95568716 |
21 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.92115422 |
22 | * RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.88986913 |
23 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.87952392 |
24 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.86860582 |
25 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.86583472 |
26 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.85804035 |
27 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.84598977 |
28 | * ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.82184127 |
29 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.74273524 |
30 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.72747053 |
31 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.72694663 |
32 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.70363958 |
33 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.69916153 |
34 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.68883952 |
35 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.65062918 |
36 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.61547082 |
37 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.61026298 |
38 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.55451233 |
39 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.53945609 |
40 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.53417110 |
41 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.38902272 |
42 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.37658477 |
43 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.36056268 |
44 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.35752861 |
45 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.34092023 |
46 | ATF3_27146783_Chip-Seq_COLON_Human | 1.33067837 |
47 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.33061144 |
48 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.32099151 |
49 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.30745700 |
50 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.28986231 |
51 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.23969712 |
52 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.22703152 |
53 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.22637275 |
54 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.21729764 |
55 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 1.21436373 |
56 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 1.20349569 |
57 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.17007670 |
58 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.13500711 |
59 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.12421735 |
60 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.10577219 |
61 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.10577219 |
62 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.08672317 |
63 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.08271979 |
64 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.07689293 |
65 | EGR1_19032775_ChIP-ChIP_M12_Human | 1.06712265 |
66 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.06442349 |
67 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.05059773 |
68 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.04532454 |
69 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.03712412 |
70 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.02075798 |
71 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.01164061 |
72 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.99792757 |
73 | KDM2B_26808549_Chip-Seq_K562_Human | 0.98774860 |
74 | GATA1_19941826_ChIP-Seq_K562_Human | 0.97339252 |
75 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.96506251 |
76 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.95641306 |
77 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.95641306 |
78 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.92761288 |
79 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.92435702 |
80 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.92372518 |
81 | TP63_23658742_ChIP-Seq_EP156T_Human | 0.89832713 |
82 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 0.89594780 |
83 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.89261797 |
84 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.87280279 |
85 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.84475049 |
86 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.84267139 |
87 | TP53_16413492_ChIP-PET_HCT116_Human | 0.84053513 |
88 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 0.83093558 |
89 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.82059406 |
90 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.81822897 |
91 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.81707686 |
92 | SA1_22415368_ChIP-Seq_MEFs_Mouse | 0.81273903 |
93 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.77915590 |
94 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.77862297 |
95 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 0.76281306 |
96 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 0.74803675 |
97 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.74567975 |
98 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.74376957 |
99 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 0.73986223 |
100 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.73533617 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0010368_abnormal_lymphatic_system | 5.54693119 |
2 | MP0004272_abnormal_basement_membrane | 4.91858974 |
3 | MP0008438_abnormal_cutaneous_collagen | 4.08827627 |
4 | MP0002877_abnormal_melanocyte_morpholog | 3.97309590 |
5 | MP0003566_abnormal_cell_adhesion | 3.95586918 |
6 | MP0001879_abnormal_lymphatic_vessel | 3.37826045 |
7 | MP0005623_abnormal_meninges_morphology | 3.13694557 |
8 | MP0003705_abnormal_hypodermis_morpholog | 2.94354114 |
9 | MP0010352_gastrointestinal_tract_polyps | 2.57619674 |
10 | MP0003279_aneurysm | 2.51918346 |
11 | MP0004510_myositis | 2.34662607 |
12 | MP0003091_abnormal_cell_migration | 2.28913065 |
13 | MP0003828_pulmonary_edema | 2.16332823 |
14 | MP0003950_abnormal_plasma_membrane | 2.15690168 |
15 | MP0005595_abnormal_vascular_smooth | 2.00387462 |
16 | MP0005023_abnormal_wound_healing | 1.94236607 |
17 | MP0010030_abnormal_orbit_morphology | 1.93198914 |
18 | MP0000767_abnormal_smooth_muscle | 1.89340972 |
19 | MP0001849_ear_inflammation | 1.84799950 |
20 | MP0005257_abnormal_intraocular_pressure | 1.76834254 |
21 | MP0002295_abnormal_pulmonary_circulatio | 1.74801991 |
22 | MP0005167_abnormal_blood-brain_barrier | 1.68151538 |
23 | MP0004084_abnormal_cardiac_muscle | 1.66732634 |
24 | MP0003303_peritoneal_inflammation | 1.62253573 |
25 | MP0009840_abnormal_foam_cell | 1.61002864 |
26 | MP0009780_abnormal_chondrocyte_physiolo | 1.57416504 |
27 | MP0002138_abnormal_hepatobiliary_system | 1.53892784 |
28 | MP0003300_gastrointestinal_ulcer | 1.52075058 |
29 | MP0002896_abnormal_bone_mineralization | 1.50260483 |
30 | MP0005275_abnormal_skin_tensile | 1.49232966 |
31 | MP0002933_joint_inflammation | 1.48952680 |
32 | MP0009697_abnormal_copulation | 1.43643696 |
33 | MP0002332_abnormal_exercise_endurance | 1.43077248 |
34 | MP0009053_abnormal_anal_canal | 1.42770500 |
35 | MP0002060_abnormal_skin_morphology | 1.39829025 |
36 | MP0006054_spinal_hemorrhage | 1.38067685 |
37 | MP0000678_abnormal_parathyroid_gland | 1.35680633 |
38 | MP0004782_abnormal_surfactant_physiolog | 1.34628189 |
39 | MP0001614_abnormal_blood_vessel | 1.32056572 |
40 | MP0005164_abnormal_response_to | 1.31973325 |
41 | MP0000467_abnormal_esophagus_morphology | 1.29449293 |
42 | MP0005409_darkened_coat_color | 1.28058158 |
43 | MP0000465_gastrointestinal_hemorrhage | 1.27452094 |
44 | MP0005165_increased_susceptibility_to | 1.26486400 |
45 | MP0002796_impaired_skin_barrier | 1.25771391 |
46 | MP0004858_abnormal_nervous_system | 1.24841956 |
47 | MP0002925_abnormal_cardiovascular_devel | 1.24071884 |
48 | MP0000751_myopathy | 1.23375790 |
49 | MP0003191_abnormal_cellular_cholesterol | 1.22726748 |
50 | MP0003448_altered_tumor_morphology | 1.21129506 |
51 | MP0001915_intracranial_hemorrhage | 1.20278121 |
52 | MP0000343_altered_response_to | 1.19400188 |
53 | MP0000858_altered_metastatic_potential | 1.18563430 |
54 | MP0001299_abnormal_eye_distance/ | 1.11783239 |
55 | MP0003453_abnormal_keratinocyte_physiol | 1.10657673 |
56 | MP0003941_abnormal_skin_development | 1.10362984 |
57 | MP0008004_abnormal_stomach_pH | 1.07964417 |
58 | MP0005508_abnormal_skeleton_morphology | 1.06453863 |
59 | MP0001542_abnormal_bone_strength | 1.03452614 |
60 | MP0001958_emphysema | 1.02492075 |
61 | MP0005197_abnormal_uvea_morphology | 1.02079822 |
62 | MP0000733_abnormal_muscle_development | 1.00755873 |
63 | MP0000249_abnormal_blood_vessel | 1.00466914 |
64 | MP0002998_abnormal_bone_remodeling | 1.00360280 |
65 | MP0006138_congestive_heart_failure | 0.99517102 |
66 | MP0008260_abnormal_autophagy | 0.97788321 |
67 | MP0000762_abnormal_tongue_morphology | 0.97732587 |
68 | MP0002128_abnormal_blood_circulation | 0.91820085 |
69 | MP0003045_fibrosis | 0.91634112 |
70 | MP0005166_decreased_susceptibility_to | 0.91229839 |
71 | MP0005451_abnormal_body_composition | 0.89852667 |
72 | MP0005501_abnormal_skin_physiology | 0.87377229 |
73 | MP0001727_abnormal_embryo_implantation | 0.86448844 |
74 | MP0005390_skeleton_phenotype | 0.84454115 |
75 | MP0001533_abnormal_skeleton_physiology | 0.83249468 |
76 | MP0000579_abnormal_nail_morphology | 0.80876543 |
77 | MP0000613_abnormal_salivary_gland | 0.80294835 |
78 | MP0004947_skin_inflammation | 0.78546405 |
79 | MP0004233_abnormal_muscle_weight | 0.76702746 |
80 | MP0002932_abnormal_joint_morphology | 0.74200613 |
81 | MP0003385_abnormal_body_wall | 0.73454396 |
82 | MP0002177_abnormal_outer_ear | 0.73369486 |
83 | MP0005621_abnormal_cell_physiology | 0.72262454 |
84 | MP0001243_abnormal_dermal_layer | 0.71927866 |
85 | MP0001216_abnormal_epidermal_layer | 0.71144491 |
86 | MP0002972_abnormal_cardiac_muscle | 0.70621394 |
87 | MP0000428_abnormal_craniofacial_morphol | 0.69582272 |
88 | MP0004036_abnormal_muscle_relaxation | 0.68920859 |
89 | MP0003436_decreased_susceptibility_to | 0.68580667 |
90 | MP0009250_abnormal_appendicular_skeleto | 0.67574778 |
91 | MP0002168_other_aberrant_phenotype | 0.66936103 |
92 | MP0000750_abnormal_muscle_regeneration | 0.66284643 |
93 | MP0002127_abnormal_cardiovascular_syste | 0.65101981 |
94 | MP0000627_abnormal_mammary_gland | 0.63794113 |
95 | MP0000013_abnormal_adipose_tissue | 0.61567229 |
96 | MP0005464_abnormal_platelet_physiology | 0.61289415 |
97 | MP0000163_abnormal_cartilage_morphology | 0.60936913 |
98 | MP0008775_abnormal_heart_ventricle | 0.60553502 |
99 | MP0004484_altered_response_of | 0.60538019 |
100 | MP0000749_muscle_degeneration | 0.60186072 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Protrusio acetabuli (HP:0003179) | 6.13766059 |
2 | Premature rupture of membranes (HP:0001788) | 5.30731720 |
3 | Arterial tortuosity (HP:0005116) | 4.79053436 |
4 | Vascular tortuosity (HP:0004948) | 4.58286246 |
5 | Atrophic scars (HP:0001075) | 4.43491219 |
6 | Cervical subluxation (HP:0003308) | 4.29773074 |
7 | Spinal rigidity (HP:0003306) | 4.22382838 |
8 | Follicular hyperkeratosis (HP:0007502) | 4.16242751 |
9 | Ankle contracture (HP:0006466) | 4.03265823 |
10 | Hematochezia (HP:0002573) | 3.80363713 |
11 | Aortic dissection (HP:0002647) | 3.60197370 |
12 | Fragile skin (HP:0001030) | 3.52399878 |
13 | Overgrowth (HP:0001548) | 3.45540934 |
14 | Spontaneous hematomas (HP:0007420) | 3.44210244 |
15 | Vertebral compression fractures (HP:0002953) | 3.43839043 |
16 | Fragile nails (HP:0001808) | 3.42283870 |
17 | Wrist flexion contracture (HP:0001239) | 3.30187767 |
18 | Polycythemia (HP:0001901) | 3.22989845 |
19 | Achilles tendon contracture (HP:0001771) | 3.21121377 |
20 | Slender build (HP:0001533) | 3.16680122 |
21 | Aortic aneurysm (HP:0004942) | 3.14009343 |
22 | Cerebral aneurysm (HP:0004944) | 3.07149275 |
23 | Esophageal varix (HP:0002040) | 3.00240703 |
24 | Genu recurvatum (HP:0002816) | 2.97570919 |
25 | Cerebral hemorrhage (HP:0001342) | 2.94540536 |
26 | Conjunctival telangiectasia (HP:0000524) | 2.92919567 |
27 | Milia (HP:0001056) | 2.87608811 |
28 | Type 1 muscle fiber predominance (HP:0003803) | 2.86280014 |
29 | Wormian bones (HP:0002645) | 2.82833335 |
30 | Abnormality of the Achilles tendon (HP:0005109) | 2.82059689 |
31 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.71399593 |
32 | Short nail (HP:0001799) | 2.70789961 |
33 | Increased variability in muscle fiber diameter (HP:0003557) | 2.65656898 |
34 | Blue sclerae (HP:0000592) | 2.61845810 |
35 | Mitral valve prolapse (HP:0001634) | 2.54236114 |
36 | Abnormality of the nasal mucosa (HP:0000433) | 2.52252468 |
37 | Abnormality of glycolipid metabolism (HP:0010969) | 2.46846325 |
38 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.46846325 |
39 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.46846325 |
40 | Menorrhagia (HP:0000132) | 2.46803994 |
41 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.44995249 |
42 | Increased connective tissue (HP:0009025) | 2.44096786 |
43 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.43540657 |
44 | Bladder diverticulum (HP:0000015) | 2.42421819 |
45 | Spondylolisthesis (HP:0003302) | 2.40307749 |
46 | Tetraparesis (HP:0002273) | 2.37652679 |
47 | Broad metatarsal (HP:0001783) | 2.36631156 |
48 | Aplasia cutis congenita (HP:0001057) | 2.36615574 |
49 | Coxa vara (HP:0002812) | 2.35057838 |
50 | Difficulty climbing stairs (HP:0003551) | 2.34977809 |
51 | Neurofibrillary tangles (HP:0002185) | 2.32297169 |
52 | Shallow orbits (HP:0000586) | 2.28492789 |
53 | Osteolytic defects of the hand bones (HP:0009699) | 2.28391244 |
54 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.28391244 |
55 | Distal upper limb amyotrophy (HP:0007149) | 2.27253197 |
56 | Upper limb amyotrophy (HP:0009129) | 2.27253197 |
57 | Trismus (HP:0000211) | 2.25358801 |
58 | Abnormality of the acetabulum (HP:0003170) | 2.24693331 |
59 | Disproportionate tall stature (HP:0001519) | 2.20758327 |
60 | Abnormality of dentin (HP:0010299) | 2.20304905 |
61 | Cardiovascular calcification (HP:0011915) | 2.19139073 |
62 | Pterygium (HP:0001059) | 2.18826501 |
63 | Hypoventilation (HP:0002791) | 2.18758014 |
64 | Joint laxity (HP:0001388) | 2.16500710 |
65 | Aneurysm (HP:0002617) | 2.15013146 |
66 | Neonatal death (HP:0003811) | 2.13199702 |
67 | Elbow flexion contracture (HP:0002987) | 2.11852756 |
68 | Soft skin (HP:0000977) | 2.09798214 |
69 | Skull defect (HP:0001362) | 2.07589634 |
70 | Generalized amyotrophy (HP:0003700) | 2.01904165 |
71 | Impaired platelet aggregation (HP:0003540) | 2.01107073 |
72 | Abnormal platelet function (HP:0011869) | 2.01107073 |
73 | Nonimmune hydrops fetalis (HP:0001790) | 2.00953027 |
74 | Obstructive sleep apnea (HP:0002870) | 1.98028526 |
75 | Portal hypertension (HP:0001409) | 1.97331631 |
76 | Dilatation of the ascending aorta (HP:0005111) | 1.96935854 |
77 | Distal lower limb amyotrophy (HP:0008944) | 1.94869059 |
78 | Cerebral inclusion bodies (HP:0100314) | 1.94569632 |
79 | Onycholysis (HP:0001806) | 1.92701995 |
80 | Natal tooth (HP:0000695) | 1.91925525 |
81 | Deep venous thrombosis (HP:0002625) | 1.91446869 |
82 | Thick nail (HP:0001805) | 1.90039395 |
83 | Broad face (HP:0000283) | 1.89964684 |
84 | Vascular calcification (HP:0004934) | 1.88575919 |
85 | Cavernous hemangioma (HP:0001048) | 1.88012134 |
86 | Porencephaly (HP:0002132) | 1.84404830 |
87 | Hand muscle atrophy (HP:0009130) | 1.84325158 |
88 | Protruding ear (HP:0000411) | 1.82908241 |
89 | Aortic valve stenosis (HP:0001650) | 1.82200699 |
90 | Syringomyelia (HP:0003396) | 1.80631182 |
91 | Spinal cord lesions (HP:0100561) | 1.80631182 |
92 | Osteopenia (HP:0000938) | 1.80217575 |
93 | Congenital glaucoma (HP:0001087) | 1.78761721 |
94 | Abnormality of the hepatic vasculature (HP:0006707) | 1.78688275 |
95 | Joint stiffness (HP:0001387) | 1.76808970 |
96 | Premature skin wrinkling (HP:0100678) | 1.76591402 |
97 | Myocardial infarction (HP:0001658) | 1.75981017 |
98 | Dysautonomia (HP:0002459) | 1.75348782 |
99 | Bronchomalacia (HP:0002780) | 1.74850154 |
100 | * Ankyloglossia (HP:0010296) | 1.70595282 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TGFBR2 | 4.25055633 |
2 | IRAK3 | 3.49475657 |
3 | NTRK1 | 2.99651214 |
4 | PDGFRA | 2.39440552 |
5 | EPHB2 | 2.36733306 |
6 | PTK2 | 2.27004750 |
7 | EPHA2 | 2.16257295 |
8 | MET | 2.15065592 |
9 | TIE1 | 10.9414210 |
10 | MST1R | 1.89030644 |
11 | PTK2B | 1.87785081 |
12 | FLT3 | 1.76827126 |
13 | PAK4 | 1.68481292 |
14 | PRKG2 | 1.67766991 |
15 | MOS | 1.65762226 |
16 | KDR | 1.51187850 |
17 | TGFBR1 | 1.42366209 |
18 | LIMK1 | 1.37675009 |
19 | ARAF | 1.34949688 |
20 | RIPK1 | 1.33224749 |
21 | ERN1 | 1.30514048 |
22 | LATS2 | 1.30285687 |
23 | EPHB1 | 1.28613361 |
24 | TTN | 1.17832661 |
25 | DDR2 | 1.17128732 |
26 | TESK1 | 1.09279477 |
27 | ZAP70 | 1.06522312 |
28 | ERBB4 | 1.06225578 |
29 | TEC | 1.02398553 |
30 | STK38 | 1.01028186 |
31 | MYLK | 0.96285041 |
32 | PDGFRB | 0.93266981 |
33 | MAP3K13 | 0.86460512 |
34 | PIM2 | 0.86319260 |
35 | FER | 0.84663020 |
36 | TRPM7 | 0.84261404 |
37 | ROCK2 | 0.83324616 |
38 | SIK1 | 0.81768290 |
39 | PRKD2 | 0.81752184 |
40 | GRK5 | 0.79895447 |
41 | FES | 0.77387484 |
42 | RPS6KA2 | 0.72341722 |
43 | MAP2K3 | 0.70689568 |
44 | SCYL2 | 0.69765521 |
45 | PAK2 | 0.68507617 |
46 | LMTK2 | 0.64836561 |
47 | ICK | 0.64493687 |
48 | JAK3 | 0.64371593 |
49 | MAP3K3 | 0.64066771 |
50 | PKN2 | 0.63354428 |
51 | PRKD3 | 0.62795024 |
52 | LATS1 | 0.62713498 |
53 | ROCK1 | 0.61855092 |
54 | CSK | 0.61552424 |
55 | TRIB3 | 0.61028063 |
56 | KSR2 | 0.60475556 |
57 | STK10 | 0.59079032 |
58 | NEK9 | 0.58188352 |
59 | PTK6 | 0.56444123 |
60 | NME2 | 0.55049626 |
61 | ABL2 | 0.52501228 |
62 | TESK2 | 0.52261655 |
63 | PRPF4B | 0.47753994 |
64 | AKT3 | 0.45743262 |
65 | BMX | 0.44977068 |
66 | CDC42BPA | 0.43556840 |
67 | PAK6 | 0.41634109 |
68 | MAP3K9 | 0.39450618 |
69 | MAP3K14 | 0.39118212 |
70 | MTOR | 0.38992317 |
71 | MAP3K8 | 0.38759960 |
72 | MAP3K12 | 0.37271184 |
73 | CDK8 | 0.36456146 |
74 | PDPK1 | 0.35795964 |
75 | FGFR4 | 0.33998840 |
76 | GSK3A | 0.32519768 |
77 | SRC | 0.31818717 |
78 | BRAF | 0.31743783 |
79 | MAP3K1 | 0.31281210 |
80 | SMG1 | 0.30865032 |
81 | GRK1 | 0.30478843 |
82 | TAOK2 | 0.30338099 |
83 | DAPK3 | 0.29337580 |
84 | ILK | 0.29093563 |
85 | ADRBK1 | 0.26660288 |
86 | DYRK1B | 0.26221895 |
87 | CDK12 | 0.26090642 |
88 | JAK1 | 0.25216747 |
89 | TBK1 | 0.25136008 |
90 | EGFR | 0.24145730 |
91 | KSR1 | 0.23845495 |
92 | PLK2 | 0.23151467 |
93 | IGF1R | 0.22750960 |
94 | MAP3K11 | 0.22299844 |
95 | LRRK2 | 0.21918231 |
96 | PAK1 | 0.21034247 |
97 | CHUK | 0.20695238 |
98 | RPS6KC1 | 0.20065558 |
99 | RPS6KL1 | 0.20065558 |
100 | GRK6 | 0.19443398 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ECM-receptor interaction_Homo sapiens_hsa04512 | 3.98897633 |
2 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 3.82971502 |
3 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 2.78957336 |
4 | Focal adhesion_Homo sapiens_hsa04510 | 2.75606184 |
5 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 2.30504438 |
6 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 2.18757560 |
7 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 2.15935295 |
8 | * Bladder cancer_Homo sapiens_hsa05219 | 2.15277534 |
9 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 2.13398663 |
10 | Small cell lung cancer_Homo sapiens_hsa05222 | 2.03803390 |
11 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.99797615 |
12 | Shigellosis_Homo sapiens_hsa05131 | 1.87877732 |
13 | Amoebiasis_Homo sapiens_hsa05146 | 1.87550820 |
14 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.80580773 |
15 | Malaria_Homo sapiens_hsa05144 | 1.71364518 |
16 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.67307103 |
17 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 1.61494641 |
18 | Pertussis_Homo sapiens_hsa05133 | 1.59402615 |
19 | Other glycan degradation_Homo sapiens_hsa00511 | 1.58619189 |
20 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.56110944 |
21 | Prion diseases_Homo sapiens_hsa05020 | 1.55522876 |
22 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.54661100 |
23 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.47161525 |
24 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.45593973 |
25 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.44107977 |
26 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.41042716 |
27 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.38642756 |
28 | Thyroid cancer_Homo sapiens_hsa05216 | 1.35460871 |
29 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.25275307 |
30 | Adherens junction_Homo sapiens_hsa04520 | 1.22294268 |
31 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.18135317 |
32 | Salmonella infection_Homo sapiens_hsa05132 | 1.16791805 |
33 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.13914011 |
34 | Axon guidance_Homo sapiens_hsa04360 | 1.13513091 |
35 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.09932024 |
36 | * Pathways in cancer_Homo sapiens_hsa05200 | 1.08037975 |
37 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 1.06619580 |
38 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.04948102 |
39 | Lysosome_Homo sapiens_hsa04142 | 1.04444681 |
40 | Phagosome_Homo sapiens_hsa04145 | 1.03740416 |
41 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.01644265 |
42 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.99854235 |
43 | * Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.98954536 |
44 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.95765509 |
45 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.95397082 |
46 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.95168261 |
47 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.93955696 |
48 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.93252709 |
49 | Platelet activation_Homo sapiens_hsa04611 | 0.91705447 |
50 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.91488032 |
51 | Glioma_Homo sapiens_hsa05214 | 0.89370451 |
52 | Melanoma_Homo sapiens_hsa05218 | 0.89280421 |
53 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.87986815 |
54 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.87974516 |
55 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.87146841 |
56 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.81820650 |
57 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.81673154 |
58 | Endocytosis_Homo sapiens_hsa04144 | 0.80680114 |
59 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.78981552 |
60 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.77888404 |
61 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.77470937 |
62 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.76673605 |
63 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.76436542 |
64 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.75847422 |
65 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.75228993 |
66 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.73988485 |
67 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.73316921 |
68 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.72560301 |
69 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.71428481 |
70 | Apoptosis_Homo sapiens_hsa04210 | 0.69807737 |
71 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.69046093 |
72 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.67789049 |
73 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.65708731 |
74 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.63925478 |
75 | Gap junction_Homo sapiens_hsa04540 | 0.61820846 |
76 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.61663588 |
77 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.61228330 |
78 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.59300894 |
79 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.58768276 |
80 | Tight junction_Homo sapiens_hsa04530 | 0.58380227 |
81 | Endometrial cancer_Homo sapiens_hsa05213 | 0.57996824 |
82 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.57697036 |
83 | Hepatitis B_Homo sapiens_hsa05161 | 0.56480346 |
84 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.55339284 |
85 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.54487458 |
86 | Galactose metabolism_Homo sapiens_hsa00052 | 0.52156606 |
87 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.51335269 |
88 | Prostate cancer_Homo sapiens_hsa05215 | 0.49654873 |
89 | Hepatitis C_Homo sapiens_hsa05160 | 0.46208549 |
90 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.44835428 |
91 | Melanogenesis_Homo sapiens_hsa04916 | 0.43323713 |
92 | Leishmaniasis_Homo sapiens_hsa05140 | 0.42924551 |
93 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.42396808 |
94 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.41646628 |
95 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.41121008 |
96 | Influenza A_Homo sapiens_hsa05164 | 0.40821091 |
97 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.40457062 |
98 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.39914653 |
99 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.39061797 |
100 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.38808196 |