MMP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.80208487
2negative regulation of keratinocyte proliferation (GO:0010839)6.86525297
3keratinocyte proliferation (GO:0043616)6.62038051
4cellular response to vitamin D (GO:0071305)6.44154622
5cell adhesion mediated by integrin (GO:0033627)6.09590341
6hemidesmosome assembly (GO:0031581)6.06821577
7chondrocyte proliferation (GO:0035988)5.73445020
8dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.47159142
9cellular response to vitamin (GO:0071295)5.22628720
10surfactant homeostasis (GO:0043129)5.21612991
11regulation of hair follicle development (GO:0051797)5.11644074
12regulation of keratinocyte proliferation (GO:0010837)4.90797151
13mesenchymal-epithelial cell signaling (GO:0060638)4.89936253
14regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.79735547
15establishment of skin barrier (GO:0061436)4.73288515
16regulation of water loss via skin (GO:0033561)4.64887415
17peptidyl-tyrosine autophosphorylation (GO:0038083)4.59661398
18endodermal cell differentiation (GO:0035987)4.54571049
19regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.53608796
20intermediate filament organization (GO:0045109)4.52688280
21positive regulation of hair cycle (GO:0042635)4.51789910
22positive regulation of hair follicle development (GO:0051798)4.51789910
23mesodermal cell differentiation (GO:0048333)4.35272948
24virion attachment to host cell (GO:0019062)4.30559651
25adhesion of symbiont to host cell (GO:0044650)4.30559651
26chemical homeostasis within a tissue (GO:0048875)4.21040382
27molting cycle (GO:0042303)4.18495511
28hair cycle (GO:0042633)4.18495511
29response to vitamin D (GO:0033280)4.04741277
30regulation of vitamin D biosynthetic process (GO:0060556)3.99120681
31epidermis development (GO:0008544)3.97362597
32negative regulation of DNA repair (GO:0045738)3.96759279
33positive regulation of epidermis development (GO:0045684)3.93443136
34renal filtration (GO:0097205)3.84989701
35regulation of histone phosphorylation (GO:0033127)3.79821483
36gap junction assembly (GO:0016264)3.77656090
37regulation of chemokine secretion (GO:0090196)3.77002945
38cell migration involved in sprouting angiogenesis (GO:0002042)3.74472247
39outer ear morphogenesis (GO:0042473)3.69267019
40negative regulation of catenin import into nucleus (GO:0035414)3.69150520
41epithelial cell differentiation involved in prostate gland development (GO:0060742)3.63859799
42regulation of transforming growth factor beta2 production (GO:0032909)3.61203821
43endothelial cell morphogenesis (GO:0001886)3.60656840
44heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.59278369
45heterochromatin organization (GO:0070828)3.53246104
46negative regulation of fatty acid transport (GO:2000192)3.52903339
47adhesion of symbiont to host (GO:0044406)3.51871114
48cellular response to nutrient (GO:0031670)3.48180381
49renal system development (GO:0072001)3.47007814
50regulation of cellular senescence (GO:2000772)3.46369462
51regulation of hydrogen peroxide metabolic process (GO:0010310)3.46053517
52decidualization (GO:0046697)3.45782010
53hypotonic response (GO:0006971)3.39326941
54receptor catabolic process (GO:0032801)3.39324348
55* extracellular matrix disassembly (GO:0022617)3.38798995
56craniofacial suture morphogenesis (GO:0097094)3.38486809
57mammary gland development (GO:0030879)3.37374816
58cell-substrate junction assembly (GO:0007044)3.37347540
59stress fiber assembly (GO:0043149)3.37059632
60negative regulation of chondrocyte differentiation (GO:0032331)3.35571938
61regulation of hair cycle (GO:0042634)3.34551684
62axon extension involved in axon guidance (GO:0048846)3.33695498
63neuron projection extension involved in neuron projection guidance (GO:1902284)3.33695498
64skin morphogenesis (GO:0043589)3.33496200
65germ cell migration (GO:0008354)3.33403211
66establishment of planar polarity (GO:0001736)3.32812540
67establishment of tissue polarity (GO:0007164)3.32812540
68positive regulation of transcription regulatory region DNA binding (GO:2000679)3.29375930
69* collagen metabolic process (GO:0032963)3.29146707
70blood vessel endothelial cell migration (GO:0043534)3.28897225
71* multicellular organismal macromolecule metabolic process (GO:0044259)3.28044635
72* multicellular organismal catabolic process (GO:0044243)3.27156030
73branch elongation of an epithelium (GO:0060602)3.25023961
74cell junction assembly (GO:0034329)3.24318421
75* collagen catabolic process (GO:0030574)3.24065656
76positive regulation of epithelial to mesenchymal transition (GO:0010718)3.22213177
77cranial suture morphogenesis (GO:0060363)3.21162519
78regulation of vitamin metabolic process (GO:0030656)3.19200044
79positive regulation of epidermal cell differentiation (GO:0045606)3.18979006
80mature B cell differentiation involved in immune response (GO:0002313)3.18308267
81maintenance of gastrointestinal epithelium (GO:0030277)3.15246139
82* multicellular organismal metabolic process (GO:0044236)3.15008100
83axis elongation (GO:0003401)3.14893256
84hepatocyte apoptotic process (GO:0097284)3.13579160
85positive regulation of actin filament depolymerization (GO:0030836)3.11453971
86regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.08725456
87gland morphogenesis (GO:0022612)3.06530082
88cellular copper ion homeostasis (GO:0006878)3.06086684
89collagen fibril organization (GO:0030199)3.02392204
90polarized epithelial cell differentiation (GO:0030859)3.01332214
91cell junction organization (GO:0034330)3.01047008
92sexual reproduction (GO:0019953)2.99868513
93positive regulation of Rho protein signal transduction (GO:0035025)2.98358170
94heparan sulfate proteoglycan metabolic process (GO:0030201)2.97807878
95lateral sprouting from an epithelium (GO:0060601)2.97220224
96apoptotic cell clearance (GO:0043277)2.96753641
97actin filament depolymerization (GO:0030042)2.95807109
98eyelid development in camera-type eye (GO:0061029)2.93336748
99regulation of epidermis development (GO:0045682)2.92546211
100bundle of His cell to Purkinje myocyte communication (GO:0086069)2.90290040
101protein localization to endosome (GO:0036010)2.90130899
102wound healing, spreading of cells (GO:0044319)2.89635727
103positive regulation of endothelial cell apoptotic process (GO:2000353)2.89618138
104wound healing, spreading of epidermal cells (GO:0035313)2.87362787
105positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.84492476
106skin development (GO:0043588)2.84350805
107regulation of membrane protein ectodomain proteolysis (GO:0051043)2.83064448
108UDP-N-acetylglucosamine metabolic process (GO:0006047)2.82057471
109L-serine transport (GO:0015825)2.81224078
110cytoskeletal anchoring at plasma membrane (GO:0007016)2.80942205
111serine transport (GO:0032329)2.80621643
112intermediate filament cytoskeleton organization (GO:0045104)2.77309985
113ectoderm development (GO:0007398)2.76487069
114angiotensin maturation (GO:0002003)2.75658840
115positive regulation of keratinocyte differentiation (GO:0045618)2.75501502
116neural crest cell development (GO:0014032)2.74856042
117glomerular filtration (GO:0003094)2.74617525
118wound healing (GO:0042060)2.74487027
119substrate-dependent cell migration (GO:0006929)2.73133488
120negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.72023621
121positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.70831984
122regulation of integrin-mediated signaling pathway (GO:2001044)2.70240594
123negative regulation of epidermis development (GO:0045683)2.69913856
124protein heterotrimerization (GO:0070208)2.69175553
125O-glycan processing (GO:0016266)2.67973146
126intermediate filament-based process (GO:0045103)2.66809055
127multicellular organismal water homeostasis (GO:0050891)2.66412087
128plasma membrane repair (GO:0001778)2.66022938
129cell migration involved in heart development (GO:0060973)2.65604140
130positive regulation of protein localization to plasma membrane (GO:1903078)2.65405127
131positive regulation of chemokine secretion (GO:0090197)2.64892266
132negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.64826088
133regulation of proton transport (GO:0010155)2.64684306
134negative regulation of anoikis (GO:2000811)2.64662340
135positive regulation of fatty acid beta-oxidation (GO:0032000)2.64148936
136keratinocyte development (GO:0003334)2.63571764
137negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.63503546
138negative regulation of smooth muscle cell migration (GO:0014912)2.63061265
139negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.62816523
140positive regulation of positive chemotaxis (GO:0050927)2.61138001
141sphingosine metabolic process (GO:0006670)2.60616070
142regulation of cell aging (GO:0090342)2.59668860
143semaphorin-plexin signaling pathway (GO:0071526)2.58903269
144insulin-like growth factor receptor signaling pathway (GO:0048009)2.58818289
145regulation of monocyte chemotaxis (GO:0090025)2.58385176
146sodium ion export (GO:0071436)2.57840186
147epithelial structure maintenance (GO:0010669)2.57334271
148response to laminar fluid shear stress (GO:0034616)2.56361169
149cellular response to interferon-alpha (GO:0035457)2.53266532
150COPI coating of Golgi vesicle (GO:0048205)2.52795866
151Golgi transport vesicle coating (GO:0048200)2.52795866
152positive regulation of astrocyte differentiation (GO:0048711)2.52435166
153regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.51627506
154regulation of transforming growth factor beta production (GO:0071634)2.51063256
155epithelial cell-cell adhesion (GO:0090136)2.51002917
156regulation of positive chemotaxis (GO:0050926)2.50422348
157positive regulation of bone remodeling (GO:0046852)2.50156638
158positive regulation of bone resorption (GO:0045780)2.50156638
159diterpenoid biosynthetic process (GO:0016102)2.49318997
160regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.49064787
161embryo implantation (GO:0007566)2.48436474
162positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.48383164
163negative regulation of response to reactive oxygen species (GO:1901032)2.47275159
164regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.46410132
165regulation of early endosome to late endosome transport (GO:2000641)2.46290218
166regulation of integrin activation (GO:0033623)2.46000330
167keratinocyte differentiation (GO:0030216)2.45622830
168cardiac right ventricle morphogenesis (GO:0003215)2.43393141
169ganglion development (GO:0061548)2.42966796
170regulation of protein heterodimerization activity (GO:0043497)2.42907573
171integrin-mediated signaling pathway (GO:0007229)2.40970672
172sphingoid metabolic process (GO:0046519)2.40121194
173Notch signaling involved in heart development (GO:0061314)2.39821615
174positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.39815624
175ventricular trabecula myocardium morphogenesis (GO:0003222)2.39473444
176type B pancreatic cell proliferation (GO:0044342)2.37196675
177glial cell proliferation (GO:0014009)2.36295542
178cellular response to nicotine (GO:0071316)2.36234139

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.28406200
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.07338430
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.67257198
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.65247288
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.50875977
6* SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.46500339
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.35258267
8CLOCK_20551151_ChIP-Seq_293T_Human2.97280607
9SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.32809247
10SOX2_20726797_ChIP-Seq_SW620_Human2.29446184
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.27431761
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24987667
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.21819458
14* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.17396549
15* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.17396549
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.16729434
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.15911087
18PPAR_26484153_Chip-Seq_NCI-H1993_Human2.02331891
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.99799454
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.96153400
21CJUN_26792858_Chip-Seq_BT549_Human1.88851099
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.88130107
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.87947669
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.87653019
25ATF3_27146783_Chip-Seq_COLON_Human1.80103660
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.76548473
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74811450
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73887601
29CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.72983457
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68665197
31JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64725865
32ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.56655643
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54958812
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.53509725
35SOX2_27498859_Chip-Seq_STOMACH_Mouse1.53033878
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.52014185
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51790414
38* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.51578905
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51006177
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.49139229
41P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48700857
42JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46614232
43GATA4_25053715_ChIP-Seq_YYC3_Human1.46502118
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.46298254
45BRD4_25478319_ChIP-Seq_HGPS_Human1.45837998
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45471485
47RACK7_27058665_Chip-Seq_MCF-7_Human1.45189103
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40524499
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40524499
50KLF5_25053715_ChIP-Seq_YYC3_Human1.39723475
51GATA6_25053715_ChIP-Seq_YYC3_Human1.39188998
52ZNF263_19887448_ChIP-Seq_K562_Human1.38609015
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37866322
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.37522555
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37322295
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35796871
57* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.31787635
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31549482
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31507216
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28654743
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28129654
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27926744
63SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26173232
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.25191424
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21063955
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18508649
67UBF1/2_26484160_Chip-Seq_HMECs_Human1.17877831
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17075176
69TCF4_18268006_ChIP-ChIP_LS174T_Human1.16525560
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.16501314
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16468634
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15381357
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15346139
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14565703
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14449896
76TFEB_21752829_ChIP-Seq_HELA_Human1.13795281
77SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13761374
78EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12204206
79LXR_22292898_ChIP-Seq_THP-1_Human1.09470793
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09467423
81* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08541554
82RUNX1_27514584_Chip-Seq_MCF-7_Human1.06732584
83TP53_16413492_ChIP-PET_HCT116_Human1.05945689
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04810526
85SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03924859
86EGR1_19032775_ChIP-ChIP_M12_Human1.02951681
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.02668035
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02469481
89IRF8_27001747_Chip-Seq_BMDM_Mouse1.02323742
90* TP63_22573176_ChIP-Seq_HFKS_Human1.00396848
91TP53_18474530_ChIP-ChIP_U2OS_Human0.99059675
92* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98202737
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97909887
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97555174
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97511855
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96955753
97AR_21909140_ChIP-Seq_LNCAP_Human0.96703562
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96571321
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96315209
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96107689
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95620940
102ELK4_26923725_Chip-Seq_MESODERM_Mouse0.91990968
103* TP63_23658742_ChIP-Seq_EP156T_Human0.91657103
104TP53_22127205_ChIP-Seq_IMR90_Human0.91599338
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89193936
106GATA3_24758297_ChIP-Seq_MCF-7_Human0.88294912
107IRF8_21731497_ChIP-ChIP_J774_Mouse0.87935790
108VDR_24787735_ChIP-Seq_THP-1_Human0.86978981
109TBX20_22080862_ChIP-Seq_HEART_Mouse0.86458309
110TBX20_22328084_ChIP-Seq_HEART_Mouse0.86458309
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85210606
112GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78040391
113BP1_19119308_ChIP-ChIP_Hs578T_Human0.77548043
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.77192984
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.76709457
116AHR_22903824_ChIP-Seq_MCF-7_Human0.75279510
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.73309116
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71915089
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.67582102
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.67536271
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.62463144
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.61665118
123NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.60252440
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.59481997
125GATA1_22025678_ChIP-Seq_K562_Human0.57961765
126ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.57751514
127TP53_23651856_ChIP-Seq_MEFs_Mouse0.56825262
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.55567079
129STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.55552701
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.52861554
131NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.51476537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology9.11814525
2MP0008438_abnormal_cutaneous_collagen4.07381540
3MP0010352_gastrointestinal_tract_polyps4.07332230
4MP0003705_abnormal_hypodermis_morpholog3.97885514
5MP0010234_abnormal_vibrissa_follicle3.56207849
6MP0005623_abnormal_meninges_morphology3.49391137
7MP0000762_abnormal_tongue_morphology3.12226915
8MP0009053_abnormal_anal_canal2.91219392
9MP0003300_gastrointestinal_ulcer2.90724980
10MP0005023_abnormal_wound_healing2.89476029
11MP0006054_spinal_hemorrhage2.81598429
12MP0003566_abnormal_cell_adhesion2.69108217
13MP0005275_abnormal_skin_tensile2.57286451
14MP0005409_darkened_coat_color2.55998997
15MP0000733_abnormal_muscle_development2.37808067
16MP0003091_abnormal_cell_migration2.36519496
17MP0002877_abnormal_melanocyte_morpholog2.24199457
18MP0003453_abnormal_keratinocyte_physiol2.08699281
19MP0004381_abnormal_hair_follicle2.06961965
20MP0005503_abnormal_tendon_morphology2.04428208
21MP0002234_abnormal_pharynx_morphology2.02863209
22MP0003045_fibrosis1.99188749
23MP0004272_abnormal_basement_membrane1.98125833
24MP0005058_abnormal_lysosome_morphology1.94662516
25MP0002060_abnormal_skin_morphology1.91991441
26MP0008260_abnormal_autophagy1.91668352
27MP0000678_abnormal_parathyroid_gland1.90688966
28MP0000858_altered_metastatic_potential1.83381267
29MP0000537_abnormal_urethra_morphology1.80426407
30MP0005257_abnormal_intraocular_pressure1.69077478
31MP0002896_abnormal_bone_mineralization1.67504988
32MP0004947_skin_inflammation1.60028292
33MP0001849_ear_inflammation1.59258561
34MP0000566_synostosis1.59054125
35MP0010307_abnormal_tumor_latency1.55849617
36MP0002933_joint_inflammation1.51963165
37MP0001958_emphysema1.51499131
38MP0003448_altered_tumor_morphology1.46440091
39MP0001666_abnormal_nutrient_absorption1.44185449
40MP0003172_abnormal_lysosome_physiology1.41666532
41MP0009384_cardiac_valve_regurgitation1.38510850
42MP0000750_abnormal_muscle_regeneration1.37938517
43MP0010678_abnormal_skin_adnexa1.36573790
44MP0009931_abnormal_skin_appearance1.34357873
45MP0003283_abnormal_digestive_organ1.33485214
46MP0003279_aneurysm1.27915017
47MP0003195_calcinosis1.25072140
48MP0009840_abnormal_foam_cell1.24362373
49MP0001243_abnormal_dermal_layer1.23529946
50MP0005164_abnormal_response_to1.22849083
51MP0005408_hypopigmentation1.20670498
52MP0001191_abnormal_skin_condition1.19853194
53MP0003191_abnormal_cellular_cholesterol1.17615513
54MP0003436_decreased_susceptibility_to1.17260466
55MP0009278_abnormal_bone_marrow1.16094158
56MP0003329_amyloid_beta_deposits1.14997746
57MP0005166_decreased_susceptibility_to1.12721409
58MP0001299_abnormal_eye_distance/1.11511404
59MP0010155_abnormal_intestine_physiology1.11254505
60MP0000490_abnormal_crypts_of1.11082101
61MP0000477_abnormal_intestine_morphology1.07901087
62MP0005501_abnormal_skin_physiology1.07442187
63MP0001533_abnormal_skeleton_physiology1.07392764
64MP0002168_other_aberrant_phenotype1.07236378
65MP0002089_abnormal_postnatal_growth/wei1.07023679
66MP0002998_abnormal_bone_remodeling1.06795794
67MP0000343_altered_response_to1.04310214
68MP0002796_impaired_skin_barrier1.04308903
69MP0005076_abnormal_cell_differentiation1.00772654
70MP0000534_abnormal_ureter_morphology0.99612751
71MP0001216_abnormal_epidermal_layer0.99492241
72MP0004883_abnormal_blood_vessel0.98364365
73MP0003303_peritoneal_inflammation0.98049815
74MP0000569_abnormal_digit_pigmentation0.97344034
75MP0003075_altered_response_to0.96846373
76MP0004782_abnormal_surfactant_physiolog0.96323981
77MP0000367_abnormal_coat/_hair0.94585954
78MP0010368_abnormal_lymphatic_system0.94023020
79MP0005508_abnormal_skeleton_morphology0.93666339
80MP0005165_increased_susceptibility_to0.92986107
81MP0010771_integument_phenotype0.91596243
82MP0004264_abnormal_extraembryonic_tissu0.91168618
83MP0000467_abnormal_esophagus_morphology0.91023672
84MP0003385_abnormal_body_wall0.90078309
85MP0003866_abnormal_defecation0.88892579
86MP0000428_abnormal_craniofacial_morphol0.88481744
87MP0003315_abnormal_perineum_morphology0.88426157
88MP0009785_altered_susceptibility_to0.88029430
89MP0008789_abnormal_olfactory_epithelium0.87294432
90MP0000627_abnormal_mammary_gland0.86877350
91MP0000462_abnormal_digestive_system0.86344877
92MP0005360_urolithiasis0.83496322
93MP0000427_abnormal_hair_cycle0.83284856
94MP0003795_abnormal_bone_structure0.83269706
95MP0000538_abnormal_urinary_bladder0.82832293
96MP0009250_abnormal_appendicular_skeleto0.81341115
97MP0004019_abnormal_vitamin_homeostasis0.80364926
98MP0005390_skeleton_phenotype0.79398252
99MP0009379_abnormal_foot_pigmentation0.79280631
100MP0005197_abnormal_uvea_morphology0.78705428
101MP0000383_abnormal_hair_follicle0.77830185
102MP0000604_amyloidosis0.77768993
103MP0002282_abnormal_trachea_morphology0.77610324
104MP0005248_abnormal_Harderian_gland0.77366737
105MP0002115_abnormal_skeleton_extremities0.76730153
106MP0002113_abnormal_skeleton_development0.76643910
107MP0002254_reproductive_system_inflammat0.76044878
108MP0001851_eye_inflammation0.75800757
109MP0001881_abnormal_mammary_gland0.75708258
110MP0005367_renal/urinary_system_phenotyp0.73865792
111MP0000516_abnormal_urinary_system0.73865792
112MP0006082_CNS_inflammation0.73704746
113MP0002098_abnormal_vibrissa_morphology0.72648115
114MP0005464_abnormal_platelet_physiology0.72359772
115MP0000377_abnormal_hair_follicle0.71995342
116MP0000647_abnormal_sebaceous_gland0.71768973
117MP0008004_abnormal_stomach_pH0.71206866
118MP0002148_abnormal_hypersensitivity_rea0.70763254
119MP0002166_altered_tumor_susceptibility0.70583627
120MP0003115_abnormal_respiratory_system0.66784148
121MP0004084_abnormal_cardiac_muscle0.66382013
122MP0005451_abnormal_body_composition0.65950687
123MP0002006_tumorigenesis0.65829406
124MP0003941_abnormal_skin_development0.65092933
125MP0004858_abnormal_nervous_system0.65012713
126MP0003828_pulmonary_edema0.63545476
127MP0003183_abnormal_peptide_metabolism0.60322186
128MP0003755_abnormal_palate_morphology0.59398150
129MP0005499_abnormal_olfactory_system0.59289971
130MP0005394_taste/olfaction_phenotype0.59289971
131MP0000767_abnormal_smooth_muscle0.58828658
132MP0003950_abnormal_plasma_membrane0.58437047
133MP0006138_congestive_heart_failure0.55661692
134MP0004885_abnormal_endolymph0.55305287
135MP0005000_abnormal_immune_tolerance0.54881573
136MP0004510_myositis0.53470633
137MP0003724_increased_susceptibility_to0.52652327
138MP0003634_abnormal_glial_cell0.50140028
139MP0005193_abnormal_anterior_eye0.50087137
140MP0002133_abnormal_respiratory_system0.50047133
141MP0005388_respiratory_system_phenotype0.50047133
142MP0005621_abnormal_cell_physiology0.50042470
143MP0001790_abnormal_immune_system0.49811989

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)7.09528981
2Thick nail (HP:0001805)6.31852238
3Protrusio acetabuli (HP:0003179)5.04743958
4Atrophic scars (HP:0001075)5.02305447
5Ridged nail (HP:0001807)4.79081508
6Hypoplasia of dental enamel (HP:0006297)4.69229737
7Abnormal blistering of the skin (HP:0008066)4.67376973
8Palmoplantar hyperkeratosis (HP:0000972)4.66045478
9Shallow orbits (HP:0000586)4.60381134
10Pili torti (HP:0003777)4.54056669
11Palmar hyperkeratosis (HP:0010765)4.40620115
12Cervical subluxation (HP:0003308)4.33043147
13Premature rupture of membranes (HP:0001788)4.17671999
14Aplasia cutis congenita (HP:0001057)3.97563756
15Subacute progressive viral hepatitis (HP:0006572)3.86605569
16Coronal craniosynostosis (HP:0004440)3.80395174
17Ankle contracture (HP:0006466)3.74925818
18Abnormal hair laboratory examination (HP:0003328)3.59443059
19Ileus (HP:0002595)3.57738036
20Milia (HP:0001056)3.55251478
21Right ventricular cardiomyopathy (HP:0011663)3.41531431
22Vertebral compression fractures (HP:0002953)3.37552083
23Selective tooth agenesis (HP:0001592)3.27948644
24Fragile skin (HP:0001030)3.24616829
25Broad metatarsal (HP:0001783)3.22589684
26Woolly hair (HP:0002224)3.18705175
27Neurofibrillary tangles (HP:0002185)3.14707506
28Abnormality of the 2nd finger (HP:0004100)3.12177286
29Buphthalmos (HP:0000557)3.09855016
30Sparse scalp hair (HP:0002209)3.09290852
31Natal tooth (HP:0000695)3.02929962
32Turricephaly (HP:0000262)2.95351376
33Sparse eyelashes (HP:0000653)2.94041602
34Anonychia (HP:0001798)2.92468535
35Rectal prolapse (HP:0002035)2.92040963
36Hypotrichosis (HP:0001006)2.91985834
37Onycholysis (HP:0001806)2.89791077
38Fragile nails (HP:0001808)2.82288390
39Hypodontia (HP:0000668)2.82139252
40Abnormality of the phalanges of the hallux (HP:0010057)2.80466436
41Esophageal atresia (HP:0002032)2.77407560
42Oral leukoplakia (HP:0002745)2.76694976
43Increased cerebral lipofuscin (HP:0011813)2.73163370
44Carious teeth (HP:0000670)2.69805868
45Micronodular cirrhosis (HP:0001413)2.68594463
46Dry hair (HP:0011359)2.65700081
47Abnormality of the distal phalanges of the toes (HP:0010182)2.59798773
48Cerebral aneurysm (HP:0004944)2.55992579
49Wormian bones (HP:0002645)2.52287901
50Increased density of long bones (HP:0006392)2.50607173
51Peritonitis (HP:0002586)2.49854029
52Cerebral inclusion bodies (HP:0100314)2.45333454
53Amniotic constriction ring (HP:0009775)2.44194533
54Abnormality of placental membranes (HP:0011409)2.44194533
55Hyperhidrosis (HP:0000975)2.43055927
56Aortic dissection (HP:0002647)2.42967647
57Abnormality of the phalanges of the 2nd finger (HP:0009541)2.41189403
58Abnormality of secondary sexual hair (HP:0009888)2.39663958
59Abnormality of the axillary hair (HP:0100134)2.39663958
60Ectropion (HP:0000656)2.37294907
61Osteolytic defects of the hand bones (HP:0009699)2.33867216
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.33867216
63Dysostosis multiplex (HP:0000943)2.33363420
64Partial duplication of the phalanx of hand (HP:0009999)2.32590589
65Radial bowing (HP:0002986)2.31414877
66Aortic aneurysm (HP:0004942)2.31114376
67Ulnar bowing (HP:0003031)2.30912749
68Blepharitis (HP:0000498)2.30206411
69Amelogenesis imperfecta (HP:0000705)2.29903808
70Congenital glaucoma (HP:0001087)2.29571279
71Genu recurvatum (HP:0002816)2.23070690
72Corneal erosion (HP:0200020)2.20171543
73Deviation of the hallux (HP:0010051)2.19319249
74Oligodontia (HP:0000677)2.19224828
75Dilatation of the ascending aorta (HP:0005111)2.18895247
76Upper limb amyotrophy (HP:0009129)2.18074042
77Distal upper limb amyotrophy (HP:0007149)2.18074042
78Advanced eruption of teeth (HP:0006288)2.17962858
79Absent eyelashes (HP:0000561)2.17677489
80Increased neuronal autofluorescent lipopigment (HP:0002074)2.17517360
81Wrist flexion contracture (HP:0001239)2.15061467
82Mucopolysacchariduria (HP:0008155)2.14727489
83Urinary glycosaminoglycan excretion (HP:0003541)2.14727489
84Abnormality of oral frenula (HP:0000190)2.14574456
85Cupped ribs (HP:0000887)2.14307907
86Increased connective tissue (HP:0009025)2.14274654
87Ureteral stenosis (HP:0000071)2.12130379
88Follicular hyperkeratosis (HP:0007502)2.11954535
89Death in infancy (HP:0001522)2.11134791
90Ankyloglossia (HP:0010296)2.10333802
91Arterial tortuosity (HP:0005116)2.09885253
92Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08654018
93Abnormality of polysaccharide metabolism (HP:0011012)2.08654018
94Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08654018
95Blue sclerae (HP:0000592)2.07090841
96Ureteral obstruction (HP:0006000)2.06722214
97Abnormality of the fingernails (HP:0001231)2.06064452
98Vascular tortuosity (HP:0004948)2.05591236
99Coxa vara (HP:0002812)2.05184826
100Fatigable weakness (HP:0003473)2.03027043
101Abnormality of the neuromuscular junction (HP:0003398)2.03027043
102Hallux valgus (HP:0001822)2.02995734
103Abnormality of the acetabulum (HP:0003170)2.00378593
104Spinal rigidity (HP:0003306)2.00204292
105Achilles tendon contracture (HP:0001771)1.98502019
106Abnormality of proline metabolism (HP:0010907)1.98393177
107Hydroxyprolinuria (HP:0003080)1.98393177
108Thin bony cortex (HP:0002753)1.97160279
109Abnormality of liposaccharide metabolism (HP:0010968)1.97089384
110Abnormality of glycosphingolipid metabolism (HP:0004343)1.97089384
111Abnormality of glycolipid metabolism (HP:0010969)1.97089384
112Slender build (HP:0001533)1.96932754
113Mildly elevated creatine phosphokinase (HP:0008180)1.95511107
114Delayed cranial suture closure (HP:0000270)1.94290420
115Flat acetabular roof (HP:0003180)1.94062742
116Hypoplastic labia majora (HP:0000059)1.93716328
117Soft skin (HP:0000977)1.92582004
118Premature loss of primary teeth (HP:0006323)1.89168518
119Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.88832314
120Type 1 muscle fiber predominance (HP:0003803)1.88692176
121Plantar hyperkeratosis (HP:0007556)1.86940844
122Skin ulcer (HP:0200042)1.85876426
123Hoarse voice (HP:0001609)1.85186701
124Bowed forearm bones (HP:0003956)1.85153062
125Bowing of the arm (HP:0006488)1.85153062
126Hand muscle atrophy (HP:0009130)1.84934838
127Elbow flexion contracture (HP:0002987)1.84281963
128Cardiovascular calcification (HP:0011915)1.83598805
129Pterygium (HP:0001059)1.83348874
130Palmoplantar keratoderma (HP:0000982)1.83294741
131Popliteal pterygium (HP:0009756)1.83080202
132Short nail (HP:0001799)1.82818854
133Aneurysm (HP:0002617)1.82106714
134Spinal cord lesions (HP:0100561)1.80848011
135Syringomyelia (HP:0003396)1.80848011
136Laryngomalacia (HP:0001601)1.80588704
137Lymphangioma (HP:0100764)1.80470883
138Interstitial pulmonary disease (HP:0006530)1.79957301
139Myocardial infarction (HP:0001658)1.77700145
140Erythema (HP:0010783)1.77379220
141Abnormality of the Achilles tendon (HP:0005109)1.77315912
142Abnormality of the distal phalanx of the thumb (HP:0009617)1.76844582
143Corneal dystrophy (HP:0001131)1.76550095
144Nail dystrophy (HP:0008404)1.76265443
145Vertebral arch anomaly (HP:0008438)1.75413233
146Dehydration (HP:0001944)1.75135936
147Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74170002
148Spinal cord compression (HP:0002176)1.73768130
149Bladder diverticulum (HP:0000015)1.73059636
150Increased mean platelet volume (HP:0011877)1.72355720
151Alopecia of scalp (HP:0002293)1.72108379
152Abnormality of the labia majora (HP:0012881)1.71800891
153Cheilitis (HP:0100825)1.70659612
154Back pain (HP:0003418)1.68176458
155Xerostomia (HP:0000217)1.66610929
156Tibial bowing (HP:0002982)1.63865808
157Lip pit (HP:0100267)1.60996002
158Parakeratosis (HP:0001036)1.60639404
159Pyloric stenosis (HP:0002021)1.59526360
160Abnormality of the salivary glands (HP:0010286)1.59182722
161Hypohidrosis (HP:0000966)1.47884225
162Abnormality of carpal bone ossification (HP:0006257)1.43791381
163Squamous cell carcinoma (HP:0002860)1.43688704
164Periodontitis (HP:0000704)1.43388295
165Septate vagina (HP:0001153)1.41429933
166Breast hypoplasia (HP:0003187)1.41359130
167Epidermoid cyst (HP:0200040)1.41092044
168Ventricular tachycardia (HP:0004756)1.39654078
169Conical tooth (HP:0000698)1.39053833
170Autoamputation (HP:0001218)1.36825102
171Vascular calcification (HP:0004934)1.35740084
172Malnutrition (HP:0004395)1.34772842
173Absent hand (HP:0004050)1.34686931
174Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.33171333
175Camptodactyly of finger (HP:0100490)1.33077333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF6.06965522
2MST1R3.93426565
3SCYL23.58309172
4TTN3.25572627
5LMTK23.11691375
6LRRK22.98264274
7DDR22.97179583
8TRIB32.91003017
9EPHA22.79431238
10FRK2.75380826
11RIPK12.63093374
12TESK12.55536879
13PKN22.44165581
14EPHB12.31216113
15BMX2.30293446
16IRAK32.24087675
17PAK42.16992068
18MET2.16075558
19FER2.12735982
20PDGFRA1.97818899
21PTK61.93565141
22MST41.85731699
23TESK21.75937984
24PRKG21.75548250
25BRAF1.74828594
26PTK21.71363232
27TIE11.60708022
28ERN11.60231548
29LIMK11.59692746
30EPHB21.57013575
31PAK21.51623219
32RAF11.48738418
33CSF1R1.33010960
34LATS11.29838555
35RPS6KA21.25816465
36EEF2K1.24988555
37MAP3K21.23162688
38STK241.21317927
39LATS21.20104867
40EPHA31.19171801
41TRPM71.18639937
42NME21.17404410
43FLT31.15635554
44PAK31.11341218
45CDK61.10974361
46PIM21.09912304
47STK101.06705904
48MOS0.96378715
49MAP2K20.93883739
50MAP3K140.92734148
51RPS6KA40.92006616
52TBK10.90524132
53ALK0.88807249
54MAP2K10.88227860
55CDC42BPA0.87784213
56IKBKB0.84897264
57PRPF4B0.84128941
58ERBB40.80290614
59FGFR10.78929878
60FGFR40.78464310
61TAOK10.76286391
62CSK0.76263235
63CAMKK10.73669733
64MAP3K80.72006033
65BLK0.71321652
66DYRK1B0.70544066
67PDGFRB0.70214171
68STK30.69268945
69GRK70.67845042
70PIK3CG0.66792252
71TGFBR10.65921350
72CAMKK20.64024534
73JAK30.61651128
74MAP3K90.59581690
75PTK2B0.59530401
76MAP3K60.58836982
77RPS6KL10.58341918
78RPS6KC10.58341918
79PAK10.57903766
80RET0.57652579
81TAOK20.56695730
82FGR0.55958739
83ILK0.55836870
84CHUK0.55322587
85STK380.55201163
86ROCK20.55072406
87CDK120.54342117
88SIK10.53959843
89ROCK10.53503253
90PRKCI0.53386775
91KSR20.52582266
92SRC0.51383946
93GRK60.51155489
94MAP3K100.50996955
95TGFBR20.50530171
96NEK90.49776955
97INSR0.49638688
98CAMK1G0.48023116
99GSK3A0.47722418
100MAPKAPK50.46898172
101PIK3CA0.46832944
102MAP3K30.46809919
103NTRK10.46645421
104KDR0.45267920
105RPS6KA60.43623050
106TYK20.42724761
107RPS6KA10.42656738
108ERBB20.42120651
109EGFR0.41994985
110ABL20.41645484
111SMG10.38700270
112CAMK1D0.38442279
113MAPKAPK20.37802405
114BMPR20.37682372
115ZAP700.37503714
116DMPK0.36958410
117MAP3K120.36497674
118FGFR30.36319777
119IGF1R0.35807187
120CLK10.35476121
121PAK60.35318366
122FYN0.34546827
123CAMK2D0.32602082
124PRKD20.32298418
125MATK0.32110939
126MAP3K10.31878089
127NEK60.31000918
128PRKCE0.29989290
129MTOR0.29909361
130CAMK2G0.29026973
131TYRO30.28636023
132PIM10.28240645
133DAPK30.27842107
134HCK0.27778296
135PRKD10.27346892
136MAP3K130.26890288
137MAPKAPK30.26886341
138JAK20.25721476
139CSNK1A1L0.24851854
140ICK0.24806333
141NEK10.24146881
142JAK10.24087986
143KSR10.24067277
144PLK20.23300395

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.98226872
2Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.76200004
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.65021614
4Renin-angiotensin system_Homo sapiens_hsa046142.60020079
5Bladder cancer_Homo sapiens_hsa052192.29207085
6Lysosome_Homo sapiens_hsa041422.26355209
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.26168712
8Proteoglycans in cancer_Homo sapiens_hsa052052.21348326
9Focal adhesion_Homo sapiens_hsa045102.11968078
10Mineral absorption_Homo sapiens_hsa049781.94920972
11Small cell lung cancer_Homo sapiens_hsa052221.94286589
12Adherens junction_Homo sapiens_hsa045201.71604342
13Fat digestion and absorption_Homo sapiens_hsa049751.70471803
14Steroid biosynthesis_Homo sapiens_hsa001001.70054726
15Amoebiasis_Homo sapiens_hsa051461.68118653
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.67859986
17Shigellosis_Homo sapiens_hsa051311.67297898
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.67174892
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.63207944
20Phagosome_Homo sapiens_hsa041451.55328195
21Prion diseases_Homo sapiens_hsa050201.53409044
22Other glycan degradation_Homo sapiens_hsa005111.45183428
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44372115
24Protein digestion and absorption_Homo sapiens_hsa049741.44221355
25Toxoplasmosis_Homo sapiens_hsa051451.38230935
26MicroRNAs in cancer_Homo sapiens_hsa052061.36532582
27Leishmaniasis_Homo sapiens_hsa051401.36214323
28ErbB signaling pathway_Homo sapiens_hsa040121.29861675
29TNF signaling pathway_Homo sapiens_hsa046681.28853616
30Vibrio cholerae infection_Homo sapiens_hsa051101.27756511
31Pertussis_Homo sapiens_hsa051331.25197489
32Salmonella infection_Homo sapiens_hsa051321.24804647
33Chronic myeloid leukemia_Homo sapiens_hsa052201.22122266
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21830734
35Malaria_Homo sapiens_hsa051441.21491021
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20917311
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13878968
38Sulfur metabolism_Homo sapiens_hsa009201.13547504
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07493269
40Notch signaling pathway_Homo sapiens_hsa043301.06795528
41Rheumatoid arthritis_Homo sapiens_hsa053231.06296434
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05182973
43Caffeine metabolism_Homo sapiens_hsa002321.03122053
44TGF-beta signaling pathway_Homo sapiens_hsa043501.02639881
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02420641
46Pancreatic cancer_Homo sapiens_hsa052121.02067221
47Tight junction_Homo sapiens_hsa045301.01667273
48Dorso-ventral axis formation_Homo sapiens_hsa043200.99364623
49Acute myeloid leukemia_Homo sapiens_hsa052210.99127928
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97514032
51Dilated cardiomyopathy_Homo sapiens_hsa054140.96179825
52Hippo signaling pathway_Homo sapiens_hsa043900.95903885
53Apoptosis_Homo sapiens_hsa042100.95153961
54Nitrogen metabolism_Homo sapiens_hsa009100.95008091
55African trypanosomiasis_Homo sapiens_hsa051430.94629783
56Melanoma_Homo sapiens_hsa052180.92985040
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92411610
58Platelet activation_Homo sapiens_hsa046110.92281153
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90739633
60p53 signaling pathway_Homo sapiens_hsa041150.89608965
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85828281
62Endometrial cancer_Homo sapiens_hsa052130.85669686
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85083722
64Glioma_Homo sapiens_hsa052140.84838994
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83591084
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81992066
67Galactose metabolism_Homo sapiens_hsa000520.81846540
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80715700
69Renin secretion_Homo sapiens_hsa049240.80119057
70PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79757501
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.79383387
72Osteoclast differentiation_Homo sapiens_hsa043800.79274825
73Bile secretion_Homo sapiens_hsa049760.78743532
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77390660
75Folate biosynthesis_Homo sapiens_hsa007900.77186524
76Thyroid cancer_Homo sapiens_hsa052160.77037043
77Tuberculosis_Homo sapiens_hsa051520.76836057
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76026272
79VEGF signaling pathway_Homo sapiens_hsa043700.74484230
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72979089
81Endocytosis_Homo sapiens_hsa041440.72208383
82Influenza A_Homo sapiens_hsa051640.71942795
83Rap1 signaling pathway_Homo sapiens_hsa040150.70998189
84Axon guidance_Homo sapiens_hsa043600.70849888
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.70373148
86Colorectal cancer_Homo sapiens_hsa052100.67191088
87HIF-1 signaling pathway_Homo sapiens_hsa040660.67050789
88Pathways in cancer_Homo sapiens_hsa052000.66388025
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64513709
90Antigen processing and presentation_Homo sapiens_hsa046120.62992829
91Thyroid hormone synthesis_Homo sapiens_hsa049180.62115011
92Legionellosis_Homo sapiens_hsa051340.60896905
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58911501
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.58513838
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58499298
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.58297507
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58209045
98Viral myocarditis_Homo sapiens_hsa054160.56659389
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56481623
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55657080
101mTOR signaling pathway_Homo sapiens_hsa041500.55634616
102Viral carcinogenesis_Homo sapiens_hsa052030.53899695
103Non-small cell lung cancer_Homo sapiens_hsa052230.53869098
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53284876
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52768157
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.51631873
107Hematopoietic cell lineage_Homo sapiens_hsa046400.51512227
108Sphingolipid metabolism_Homo sapiens_hsa006000.51316545
109GnRH signaling pathway_Homo sapiens_hsa049120.50843724
110Renal cell carcinoma_Homo sapiens_hsa052110.48957425
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48541656
112Hepatitis C_Homo sapiens_hsa051600.46482862
113Vitamin digestion and absorption_Homo sapiens_hsa049770.46005096
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45300337
115Pancreatic secretion_Homo sapiens_hsa049720.45286913
116Hepatitis B_Homo sapiens_hsa051610.43554971
117Gap junction_Homo sapiens_hsa045400.43434733
118Insulin signaling pathway_Homo sapiens_hsa049100.42597285
119Starch and sucrose metabolism_Homo sapiens_hsa005000.42291504
120Measles_Homo sapiens_hsa051620.42072734
121Type II diabetes mellitus_Homo sapiens_hsa049300.41922750
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41846366
123Estrogen signaling pathway_Homo sapiens_hsa049150.40819350
124Prostate cancer_Homo sapiens_hsa052150.40542181
125N-Glycan biosynthesis_Homo sapiens_hsa005100.39507123
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38499566
127Prolactin signaling pathway_Homo sapiens_hsa049170.37707571
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36889709
129Complement and coagulation cascades_Homo sapiens_hsa046100.36251668

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