MMP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1atrioventricular valve morphogenesis (GO:0003181)6.97094308
2regulation of cardioblast differentiation (GO:0051890)6.64574226
3regulation of secondary heart field cardioblast proliferation (GO:0003266)5.48564537
4regulation of cardioblast proliferation (GO:0003264)5.48564537
5paraxial mesoderm development (GO:0048339)5.42911607
6protein heterotrimerization (GO:0070208)5.38390560
7intestinal epithelial cell development (GO:0060576)4.82847435
8chondrocyte proliferation (GO:0035988)4.65289186
9bone trabecula formation (GO:0060346)4.52264997
10* collagen fibril organization (GO:0030199)4.42198148
11pericardium development (GO:0060039)4.37766462
12establishment of tissue polarity (GO:0007164)4.33475862
13establishment of planar polarity (GO:0001736)4.33475862
14tooth mineralization (GO:0034505)4.27128700
15estrogen biosynthetic process (GO:0006703)4.26430306
16cell aggregation (GO:0098743)4.22638086
17cartilage condensation (GO:0001502)4.22638086
18negative regulation of cardiac muscle tissue growth (GO:0055022)4.21263022
19negative regulation of heart growth (GO:0061117)4.21263022
20positive regulation of osteoblast proliferation (GO:0033690)4.18339950
21atrial septum morphogenesis (GO:0060413)4.16617526
22negative regulation of biomineral tissue development (GO:0070168)4.01532963
23endochondral ossification (GO:0001958)3.98178003
24replacement ossification (GO:0036075)3.98178003
25polarized epithelial cell differentiation (GO:0030859)3.97896711
26planar cell polarity pathway involved in neural tube closure (GO:0090179)3.97500784
27non-canonical Wnt signaling pathway (GO:0035567)3.88934193
28sequestering of extracellular ligand from receptor (GO:0035581)3.79414361
29heart valve morphogenesis (GO:0003179)3.73588007
30endodermal cell differentiation (GO:0035987)3.73044180
31regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.71991222
32embryonic skeletal joint morphogenesis (GO:0060272)3.69229956
33cardiac ventricle formation (GO:0003211)3.69062690
34craniofacial suture morphogenesis (GO:0097094)3.63211406
35metanephric mesenchyme development (GO:0072075)3.57301220
36anatomical structure regression (GO:0060033)3.56717653
37peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.55393948
38regulation of SMAD protein import into nucleus (GO:0060390)3.55160056
39gonadal mesoderm development (GO:0007506)3.54906786
40positive regulation of SMAD protein import into nucleus (GO:0060391)3.54584904
41glomerular basement membrane development (GO:0032836)3.54306004
42positive regulation of protein kinase C signaling (GO:0090037)3.52914427
43embryonic skeletal system development (GO:0048706)3.50276289
44positive regulation of respiratory burst (GO:0060267)3.49283280
45response to follicle-stimulating hormone (GO:0032354)3.44456186
46cardiac chamber formation (GO:0003207)3.43217700
47regulation of gonadotropin secretion (GO:0032276)3.42250733
48cochlea morphogenesis (GO:0090103)3.38625745
49positive regulation of macrophage activation (GO:0043032)3.38454184
50hippo signaling (GO:0035329)3.33668959
51kidney mesenchyme development (GO:0072074)3.31269204
52negative regulation of cardiac muscle tissue development (GO:0055026)3.28155793
53establishment of apical/basal cell polarity (GO:0035089)3.27245681
54ventricular septum development (GO:0003281)3.24502014
55desmosome organization (GO:0002934)3.24440577
56outer ear morphogenesis (GO:0042473)3.22903709
57G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.22397097
58negative regulation of gluconeogenesis (GO:0045721)3.21975041
59axon extension involved in axon guidance (GO:0048846)3.15762540
60neuron projection extension involved in neuron projection guidance (GO:1902284)3.15762540
61glomerular filtration (GO:0003094)3.15401142
62organ formation (GO:0048645)3.13965974
63cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.13306383
64negative regulation of chondrocyte differentiation (GO:0032331)3.12768899
65* collagen metabolic process (GO:0032963)3.10626875
66inner ear receptor stereocilium organization (GO:0060122)3.09176580
67regulation of odontogenesis (GO:0042481)3.08484775
68cell proliferation involved in metanephros development (GO:0072203)3.07143955
69head development (GO:0060322)3.06917742
70embryonic cranial skeleton morphogenesis (GO:0048701)3.05634204
71skin morphogenesis (GO:0043589)3.05581500
72regulation of posttranscriptional gene silencing (GO:0060147)3.05563724
73regulation of gene silencing by miRNA (GO:0060964)3.05563724
74regulation of gene silencing by RNA (GO:0060966)3.05563724
75proximal/distal pattern formation (GO:0009954)3.05028549
76negative regulation of epithelial to mesenchymal transition (GO:0010719)3.04263256
77* collagen catabolic process (GO:0030574)3.03600326
78renal filtration (GO:0097205)3.03198227
79regulation of heart morphogenesis (GO:2000826)3.02741474
80regulation of extracellular matrix disassembly (GO:0010715)3.02527612
81cartilage development (GO:0051216)3.01355684
82* basement membrane organization (GO:0071711)3.00552984
83bone morphogenesis (GO:0060349)3.00368158
84dermatan sulfate metabolic process (GO:0030205)2.97560781
85regulation of chondrocyte differentiation (GO:0032330)2.97515354
86regulation of apoptotic cell clearance (GO:2000425)2.96670866
87bone mineralization (GO:0030282)2.96522170
88apoptotic cell clearance (GO:0043277)2.95122027
89regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.93533246
90embryonic forelimb morphogenesis (GO:0035115)2.92636096
91cranial suture morphogenesis (GO:0060363)2.91026015
92anterior/posterior axis specification, embryo (GO:0008595)2.89532776
93blood vessel maturation (GO:0001955)2.89145944
94* multicellular organismal macromolecule metabolic process (GO:0044259)2.87860505
95genitalia morphogenesis (GO:0035112)2.87774334
96protein trimerization (GO:0070206)2.87741308
97positive regulation of epithelial to mesenchymal transition (GO:0010718)2.87191730
98regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.85553703
99heterochromatin organization (GO:0070828)2.85373330
100regulation of hippo signaling (GO:0035330)2.84551773
101mesenchyme development (GO:0060485)2.84268306
102endocardial cushion development (GO:0003197)2.83769869
103negative regulation of DNA repair (GO:0045738)2.83525442
104negative regulation of protein activation cascade (GO:2000258)2.82790179
105mesenchymal cell proliferation (GO:0010463)2.81019833
106regulation of response to tumor cell (GO:0002834)2.80401261
107positive regulation of response to tumor cell (GO:0002836)2.80401261
108positive regulation of immune response to tumor cell (GO:0002839)2.80401261
109regulation of immune response to tumor cell (GO:0002837)2.80401261
110notochord development (GO:0030903)2.80245518
111vascular endothelial growth factor signaling pathway (GO:0038084)2.80241307
112* extracellular matrix organization (GO:0030198)2.80227508
113* extracellular structure organization (GO:0043062)2.79662599
114adhesion of symbiont to host (GO:0044406)2.79391044
115convergent extension (GO:0060026)2.78796452
116organ induction (GO:0001759)2.75362649
117* multicellular organismal catabolic process (GO:0044243)2.74954020
118wound healing, spreading of epidermal cells (GO:0035313)2.74305042
119positive regulation of endothelial cell apoptotic process (GO:2000353)2.74049443
120extracellular fibril organization (GO:0043206)2.72671706
121cell migration involved in heart development (GO:0060973)2.72624677
122establishment of monopolar cell polarity (GO:0061162)2.71994043
123establishment or maintenance of monopolar cell polarity (GO:0061339)2.71994043
124ossification (GO:0001503)2.70651368
125positive regulation of stem cell differentiation (GO:2000738)2.69568290
126* multicellular organismal metabolic process (GO:0044236)2.68026792
127adhesion of symbiont to host cell (GO:0044650)2.67795944
128virion attachment to host cell (GO:0019062)2.67795944
129gastrulation with mouth forming second (GO:0001702)2.67674754
130negative regulation of cartilage development (GO:0061037)2.66922059
131embryonic camera-type eye development (GO:0031076)2.66664720
132middle ear morphogenesis (GO:0042474)2.65246632
133regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.63523898
134epithelial cell-cell adhesion (GO:0090136)2.62920184
135glial cell migration (GO:0008347)2.62314748
136Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.60200348
137negative regulation of fatty acid transport (GO:2000192)2.58497164
138branching involved in mammary gland duct morphogenesis (GO:0060444)2.57220430
139* extracellular matrix disassembly (GO:0022617)2.54604087
140morphogenesis of an endothelium (GO:0003159)2.53241693
141endothelial tube morphogenesis (GO:0061154)2.53241693
142negative regulation of complement activation (GO:0045916)2.52877685
143negative regulation of catenin import into nucleus (GO:0035414)2.51778127
144prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.51378572
145regulation of tight junction assembly (GO:2000810)2.50989960
146mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.50668062
147regulation of establishment of planar polarity (GO:0090175)2.50642372
148regulation of mitotic spindle organization (GO:0060236)2.49851396
149positive regulation of cartilage development (GO:0061036)2.49682125
150cell proliferation involved in kidney development (GO:0072111)2.49666491
151positive regulation of mesenchymal cell proliferation (GO:0002053)2.48793872
152uterus development (GO:0060065)2.43954696
153regulation of gastrulation (GO:0010470)2.42962560
154endothelial cell proliferation (GO:0001935)2.41861582
155regulation of cartilage development (GO:0061035)2.41735596
156keratan sulfate catabolic process (GO:0042340)2.40813505
157regulation of transforming growth factor beta2 production (GO:0032909)2.38856612
158chondrocyte development (GO:0002063)2.37334395
159regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.36090739
160negative regulation of embryonic development (GO:0045992)2.35270449
161substrate adhesion-dependent cell spreading (GO:0034446)2.34460630
162cellular response to interferon-alpha (GO:0035457)2.34325294
163dermatan sulfate biosynthetic process (GO:0030208)2.33809236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.14986916
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.49048666
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.42666400
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.32407031
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.27702149
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.26862872
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.11959338
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.89951914
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.89951914
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.89951914
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.84638544
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73199180
13CLOCK_20551151_ChIP-Seq_293T_Human2.57931740
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.55462927
15* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.53833548
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.42488564
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.36120681
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.35549199
19RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.32882308
20ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.22026946
21ZFP281_18757296_ChIP-ChIP_E14_Mouse2.18481661
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.14677875
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.07628333
24* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.06589713
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.05933413
26* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.05166719
27ESR2_21235772_ChIP-Seq_MCF-7_Human2.04347144
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.02066591
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.01744545
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.99627355
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.99616109
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.98110943
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.95515044
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.92609450
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86258548
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.81256387
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.79502989
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.78906328
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74537406
40* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.70085783
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.67827330
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66047546
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.65330410
44* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.65019440
45SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.64385779
46AR_21909140_ChIP-Seq_LNCAP_Human1.64211219
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.62685931
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62522603
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60971435
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59195726
51CJUN_26792858_Chip-Seq_BT549_Human1.52769963
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52207918
53P63_26484246_Chip-Seq_KERATINOCYTES_Human1.50163696
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.48539208
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.47913817
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47869976
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47000304
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46488006
59KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.46080116
60* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.45716820
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45099033
62ZNF263_19887448_ChIP-Seq_K562_Human1.44844767
63BRD4_25478319_ChIP-Seq_HGPS_Human1.44568538
64DROSHA_22980978_ChIP-Seq_HELA_Human1.43930551
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42329538
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42329538
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40807996
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.40634647
69MYC_22102868_ChIP-Seq_BL_Human1.40438307
70EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40380676
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38477263
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.36980542
73ESR1_21235772_ChIP-Seq_MCF-7_Human1.35267548
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35026164
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33941347
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33389802
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.33104890
78TP53_22127205_ChIP-Seq_IMR90_Human1.33051049
79* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.32997357
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30463080
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30294452
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29546506
83DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29522131
84* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28505973
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27749790
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26734906
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.26668687
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26153517
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25874580
90RACK7_27058665_Chip-Seq_MCF-7_Human1.24000378
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23784228
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23593060
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23349544
94* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.23151798
95SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22874733
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.22866184
97* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22536643
98ATF3_27146783_Chip-Seq_COLON_Human1.22470643
99KDM2B_26808549_Chip-Seq_DND41_Human1.21940221
100EZH2_27294783_Chip-Seq_ESCs_Mouse1.21926126
101* RXR_22158963_ChIP-Seq_LIVER_Mouse1.21215362
102NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20153372
103CTCF_27219007_Chip-Seq_Bcells_Human1.19933203
104* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18386673
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18180961
106SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17421218
107* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16235065
108NANOG_21062744_ChIP-ChIP_HESCs_Human1.15697778
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15421157
110SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14523486
111SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14306343
112* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13614686
113FOXA2_19822575_ChIP-Seq_HepG2_Human1.13056928
114SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12889961
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.12881249
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.12861914
117MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12508145
118ISL1_27105846_Chip-Seq_CPCs_Mouse1.11744465
119UBF1/2_26484160_Chip-Seq_HMECs_Human1.11587283
120MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11553478
121SOX2_20726797_ChIP-Seq_SW620_Human1.11409410
122KDM2B_26808549_Chip-Seq_K562_Human1.11244453
123SMC3_22415368_ChIP-Seq_MEFs_Mouse1.11165952
124EZH2_27304074_Chip-Seq_ESCs_Mouse1.10803599
125CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10105841
126* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10060884
127PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09901348
128GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09852786
129* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08632782
130PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07885650
131VDR_21846776_ChIP-Seq_THP-1_Human1.07320394
132SA1_22415368_ChIP-Seq_MEFs_Mouse1.07304249
133RUNX1_27514584_Chip-Seq_MCF-7_Human1.07216722
134* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.07152686
135RNF2_27304074_Chip-Seq_ESCs_Mouse1.06803898
136* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06152007
137NANOG_16153702_ChIP-ChIP_HESCs_Human1.06057326
138KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05027676
139LXR_22292898_ChIP-Seq_THP-1_Human1.03911613
140HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03691370
141NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02713111
142* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.02455596
143POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02235312
144JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02147420
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01921300
146* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00755860
147RING1B_27294783_Chip-Seq_ESCs_Mouse1.00639609
148EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00328211
149GATA2_21666600_ChIP-Seq_HMVEC_Human1.00179357
150TP53_23651856_ChIP-Seq_MEFs_Mouse1.00147793
151IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99535398
152SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99522872
153FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98262664
154MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97927828
155* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97748737
156TBX20_22080862_ChIP-Seq_HEART_Mouse0.97111880
157TBX20_22328084_ChIP-Seq_HEART_Mouse0.97111880
158* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96793393
159ESR1_20079471_ChIP-ChIP_T-47D_Human0.96393521
160KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95635305
161SA1_27219007_Chip-Seq_ERYTHROID_Human0.95028094
162SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93412105
163ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93085382
164CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91709948
165TP63_22573176_ChIP-Seq_HFKS_Human0.91421081
166TP53_18474530_ChIP-ChIP_U2OS_Human0.90249394
167AHR_22903824_ChIP-Seq_MCF-7_Human0.90036500
168ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89142881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.67576126
2MP0005503_abnormal_tendon_morphology3.96070740
3MP0003705_abnormal_hypodermis_morpholog3.78524624
4MP0005275_abnormal_skin_tensile3.46757578
5MP0003279_aneurysm2.89750568
6MP0004272_abnormal_basement_membrane2.81634148
7MP0001958_emphysema2.67218787
8MP0005623_abnormal_meninges_morphology2.46317288
9MP0006054_spinal_hemorrhage2.45599268
10MP0010030_abnormal_orbit_morphology2.45248429
11MP0004134_abnormal_chest_morphology2.36837625
12MP0003385_abnormal_body_wall2.12495474
13MP0000462_abnormal_digestive_system2.11175706
14MP0010352_gastrointestinal_tract_polyps2.01731026
15MP0005508_abnormal_skeleton_morphology2.00255328
16MP0003566_abnormal_cell_adhesion1.93239705
17MP0003941_abnormal_skin_development1.89675485
18MP0001348_abnormal_lacrimal_gland1.88645630
19MP0000013_abnormal_adipose_tissue1.86423630
20MP0005023_abnormal_wound_healing1.85167856
21MP0009053_abnormal_anal_canal1.76382713
22MP0000733_abnormal_muscle_development1.70910249
23MP0003123_paternal_imprinting1.67365924
24MP0000537_abnormal_urethra_morphology1.61012147
25MP0003942_abnormal_urinary_system1.57993826
26MP0000534_abnormal_ureter_morphology1.54890741
27MP0003115_abnormal_respiratory_system1.50923732
28MP0002282_abnormal_trachea_morphology1.50342038
29MP0009250_abnormal_appendicular_skeleto1.49700434
30MP0000428_abnormal_craniofacial_morphol1.49351264
31MP0009384_cardiac_valve_regurgitation1.48328215
32MP0000049_abnormal_middle_ear1.46932371
33MP0003567_abnormal_fetal_cardiomyocyte1.45129015
34MP0000767_abnormal_smooth_muscle1.42067064
35MP0002060_abnormal_skin_morphology1.41620485
36MP0002932_abnormal_joint_morphology1.40382358
37MP0002249_abnormal_larynx_morphology1.37029046
38MP0005076_abnormal_cell_differentiation1.30126113
39MP0005248_abnormal_Harderian_gland1.28627246
40MP0002108_abnormal_muscle_morphology1.27427314
41MP0004197_abnormal_fetal_growth/weight/1.27304345
42MP0003283_abnormal_digestive_organ1.27012550
43MP0003091_abnormal_cell_migration1.26883919
44MP0003935_abnormal_craniofacial_develop1.23222852
45MP0001849_ear_inflammation1.19397253
46MP0000003_abnormal_adipose_tissue1.17693735
47MP0002933_joint_inflammation1.16674692
48MP0002295_abnormal_pulmonary_circulatio1.15877513
49MP0002254_reproductive_system_inflammat1.13934394
50MP0003122_maternal_imprinting1.13312009
51MP0003755_abnormal_palate_morphology1.11741351
52MP0010368_abnormal_lymphatic_system1.09110510
53MP0003937_abnormal_limbs/digits/tail_de1.08842292
54MP0002111_abnormal_tail_morphology1.08556815
55MP0003119_abnormal_digestive_system1.08300008
56MP0003121_genomic_imprinting1.07230637
57MP0010307_abnormal_tumor_latency1.07048684
58MP0002085_abnormal_embryonic_tissue1.06500487
59MP0001542_abnormal_bone_strength1.05175530
60MP0002896_abnormal_bone_mineralization1.04144374
61MP0000432_abnormal_head_morphology1.03775325
62MP0002115_abnormal_skeleton_extremities1.03745250
63MP0002084_abnormal_developmental_patter1.03225264
64MP0002925_abnormal_cardiovascular_devel1.02794403
65MP0000750_abnormal_muscle_regeneration1.02032017
66MP0000163_abnormal_cartilage_morphology1.01626552
67MP0005257_abnormal_intraocular_pressure0.99582561
68MP0002116_abnormal_craniofacial_bone0.99550734
69MP0000516_abnormal_urinary_system0.99113413
70MP0005367_renal/urinary_system_phenotyp0.99113413
71MP0002114_abnormal_axial_skeleton0.98957211
72MP0002653_abnormal_ependyma_morphology0.98696555
73MP0005171_absent_coat_pigmentation0.97169690
74MP0003045_fibrosis0.95697858
75MP0004957_abnormal_blastocyst_morpholog0.94697219
76MP0002113_abnormal_skeleton_development0.92874647
77MP0000751_myopathy0.92796513
78MP0001243_abnormal_dermal_layer0.92261325
79MP0001175_abnormal_lung_morphology0.91190268
80MP0002086_abnormal_extraembryonic_tissu0.90835040
81MP0002109_abnormal_limb_morphology0.89772466
82MP0003315_abnormal_perineum_morphology0.88759796
83MP0001293_anophthalmia0.88216975
84MP0003795_abnormal_bone_structure0.87724981
85MP0008007_abnormal_cellular_replicative0.86982401
86MP0001614_abnormal_blood_vessel0.86781550
87MP0000749_muscle_degeneration0.86430455
88MP0005380_embryogenesis_phenotype0.86049025
89MP0001672_abnormal_embryogenesis/_devel0.86049025
90MP0009278_abnormal_bone_marrow0.85063878
91MP0001879_abnormal_lymphatic_vessel0.84919485
92MP0000350_abnormal_cell_proliferation0.84550124
93MP0002088_abnormal_embryonic_growth/wei0.84373146
94MP0003984_embryonic_growth_retardation0.83742307
95MP0002168_other_aberrant_phenotype0.83578950
96MP0005390_skeleton_phenotype0.83508379
97MP0002233_abnormal_nose_morphology0.82698881
98MP0002876_abnormal_thyroid_physiology0.82415238
99MP0000681_abnormal_thyroid_gland0.82029384
100MP0002092_abnormal_eye_morphology0.80914457
101MP0000762_abnormal_tongue_morphology0.80724231
102MP0002697_abnormal_eye_size0.79855824
103MP0004084_abnormal_cardiac_muscle0.78995777
104MP0001915_intracranial_hemorrhage0.78914673
105MP0002128_abnormal_blood_circulation0.78734828
106MP0002089_abnormal_postnatal_growth/wei0.78317392
107MP0003077_abnormal_cell_cycle0.78042481
108MP0001697_abnormal_embryo_size0.77300673
109MP0004233_abnormal_muscle_weight0.76843653
110MP0000566_synostosis0.76744415
111MP0009780_abnormal_chondrocyte_physiolo0.75601990
112MP0004133_heterotaxia0.74688529
113MP0003111_abnormal_nucleus_morphology0.73782713
114MP0002160_abnormal_reproductive_system0.73726066
115MP0005058_abnormal_lysosome_morphology0.69692824
116MP0008260_abnormal_autophagy0.68309236
117MP0001299_abnormal_eye_distance/0.68088463
118MP0002998_abnormal_bone_remodeling0.67695863
119MP0005369_muscle_phenotype0.66460260
120MP0009840_abnormal_foam_cell0.62302297
121MP0002751_abnormal_autonomic_nervous0.56939325
122MP0000678_abnormal_parathyroid_gland0.56717351
123MP0001270_distended_abdomen0.52999408
124MP0010234_abnormal_vibrissa_follicle0.52701748
125MP0000639_abnormal_adrenal_gland0.49962877
126MP0005193_abnormal_anterior_eye0.49254620
127MP0010329_abnormal_lipoprotein_level0.44290125
128MP0001666_abnormal_nutrient_absorption0.43012066
129MP0000026_abnormal_inner_ear0.42329188
130MP0006138_congestive_heart_failure0.42017094
131MP0010771_integument_phenotype0.41918881
132MP0000470_abnormal_stomach_morphology0.41286493
133MP0000383_abnormal_hair_follicle0.40342559
134MP0000538_abnormal_urinary_bladder0.40179201
135MP0005381_digestive/alimentary_phenotyp0.40145797
136MP0001340_abnormal_eyelid_morphology0.39638226
137MP0004858_abnormal_nervous_system0.37187631
138MP0000467_abnormal_esophagus_morphology0.36541368
139MP0004019_abnormal_vitamin_homeostasis0.36349642

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.34150104
2Protrusio acetabuli (HP:0003179)6.28012661
3Vitreoretinal degeneration (HP:0000655)5.49282391
4Metaphyseal cupping (HP:0003021)5.20841835
5Ankle contracture (HP:0006466)4.88010542
6Aplasia of the musculature (HP:0100854)4.84471511
7Metaphyseal dysplasia (HP:0100255)4.79697953
8Mild short stature (HP:0003502)4.68376796
9Cupped ribs (HP:0000887)4.27744305
10Aortic dissection (HP:0002647)4.25725864
11Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.25307209
12Shallow orbits (HP:0000586)4.19982519
13Cerebral aneurysm (HP:0004944)4.12635340
14Broad metatarsal (HP:0001783)3.77831488
15Abnormality of the ischium (HP:0003174)3.69271884
16Abnormality of the frontal sinuses (HP:0002687)3.67730984
17Irregular vertebral endplates (HP:0003301)3.62237994
18Soft skin (HP:0000977)3.54535476
19Aortic aneurysm (HP:0004942)3.49322570
20Bladder diverticulum (HP:0000015)3.46938198
21Nonimmune hydrops fetalis (HP:0001790)3.44759354
22Partial duplication of the phalanx of hand (HP:0009999)3.42834252
23Tibial bowing (HP:0002982)3.30856999
24Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.30780415
25Cervical subluxation (HP:0003308)3.27641307
26Atrophic scars (HP:0001075)3.24899825
27Genu varum (HP:0002970)3.19894518
28Coxa vara (HP:0002812)3.17335924
29Wrist flexion contracture (HP:0001239)3.10432637
30Femoral bowing (HP:0002980)3.09961140
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.09935824
32Short 4th metacarpal (HP:0010044)3.09935824
33Ulnar bowing (HP:0003031)3.04735790
34Type 1 muscle fiber predominance (HP:0003803)3.00227310
35Blue sclerae (HP:0000592)2.99717908
36Partial duplication of thumb phalanx (HP:0009944)2.96385384
37Small epiphyses (HP:0010585)2.94533095
38Anomalous pulmonary venous return (HP:0010772)2.94530542
39Fragile skin (HP:0001030)2.89870789
40Irregular epiphyses (HP:0010582)2.88609555
41Abnormality of dentin (HP:0010299)2.85195088
42Abnormality of the vertebral endplates (HP:0005106)2.84657021
43Enlarged epiphyses (HP:0010580)2.83754361
44Osteoarthritis (HP:0002758)2.79795395
45Abnormality of the 4th metacarpal (HP:0010012)2.79466192
46Dilatation of the ascending aorta (HP:0005111)2.79285436
47Abnormality of femoral epiphyses (HP:0006499)2.76068155
48Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.76068155
49Mitral valve prolapse (HP:0001634)2.74607903
50Hypoplastic left heart (HP:0004383)2.62052716
51Abnormality of the pulmonary veins (HP:0011718)2.58346528
52Protuberant abdomen (HP:0001538)2.57975987
53Thin ribs (HP:0000883)2.54789820
54Neonatal short-limb short stature (HP:0008921)2.53724812
55Spondylolisthesis (HP:0003302)2.53255620
56Wormian bones (HP:0002645)2.52824749
57Selective tooth agenesis (HP:0001592)2.48753237
58Arthropathy (HP:0003040)2.47745150
59Abnormal vertebral ossification (HP:0100569)2.47050622
60Wide anterior fontanel (HP:0000260)2.46711232
61Peritonitis (HP:0002586)2.43945293
62Vascular tortuosity (HP:0004948)2.43148372
63Genu recurvatum (HP:0002816)2.42510369
64Hypoplastic heart (HP:0001961)2.40121696
65Follicular hyperkeratosis (HP:0007502)2.39483407
66Spinal rigidity (HP:0003306)2.38146292
67Abnormal delivery (HP:0001787)2.36574616
68Aplasia/Hypoplasia involving the musculature (HP:0001460)2.36004192
69Bowel diverticulosis (HP:0005222)2.35466706
70Aneurysm (HP:0002617)2.35102586
71Flattened epiphyses (HP:0003071)2.34045489
72Vertebral compression fractures (HP:0002953)2.33484533
73Disproportionate short-trunk short stature (HP:0003521)2.33356357
74Infantile muscular hypotonia (HP:0008947)2.32608522
75Short middle phalanx of finger (HP:0005819)2.32047603
76Mesomelia (HP:0003027)2.31912273
77Renal duplication (HP:0000075)2.29774674
78Arterial tortuosity (HP:0005116)2.27762067
79Radial bowing (HP:0002986)2.25700635
80Joint laxity (HP:0001388)2.25356520
81Slender build (HP:0001533)2.22231431
82Flared iliac wings (HP:0002869)2.19777391
83Hyperextensible skin (HP:0000974)2.19318255
84Bowed forearm bones (HP:0003956)2.16343615
85Bowing of the arm (HP:0006488)2.16343615
86Ectopia lentis (HP:0001083)2.15380530
87Increased connective tissue (HP:0009025)2.14828189
88Delayed closure of the anterior fontanelle (HP:0001476)2.14058429
89Platyspondyly (HP:0000926)2.13477682
90Patent foramen ovale (HP:0001655)2.13016878
91Deviation of the hallux (HP:0010051)2.12034782
92Coronal craniosynostosis (HP:0004440)2.11943913
93Abnormality of the phalanges of the 2nd finger (HP:0009541)2.10947705
94Rectal prolapse (HP:0002035)2.10885332
95Mitral stenosis (HP:0001718)2.06948404
96Elbow flexion contracture (HP:0002987)2.06167390
97Short middle phalanx of the 5th finger (HP:0004220)2.05622011
98Osteolytic defects of the phalanges of the hand (HP:0009771)2.04930641
99Osteolytic defects of the hand bones (HP:0009699)2.04930641
100Abnormality of the acetabulum (HP:0003170)2.04909857
101Mildly elevated creatine phosphokinase (HP:0008180)2.04689279
102Abnormality of the 2nd finger (HP:0004100)2.04647916
103Biconcave vertebral bodies (HP:0004586)2.00421262
104Increased corneal curvature (HP:0100692)2.00264354
105Keratoconus (HP:0000563)2.00264354
106Abnormality of the epiphysis of the femoral head (HP:0010574)2.00053129
107Sprengel anomaly (HP:0000912)1.98624576
108Rib fusion (HP:0000902)1.98310250
109Morphological abnormality of the middle ear (HP:0008609)1.98222008
110Ulnar claw (HP:0001178)1.97689980
111Abnormality of the epiphyses of the hand (HP:0005924)1.97606637
112Hallux valgus (HP:0001822)1.97253513
113Camptodactyly of toe (HP:0001836)1.97223078
114Abnormality of the peritoneum (HP:0002585)1.97213152
115Abnormality of the femoral head (HP:0003368)1.96644537
116Abnormality of the calcaneus (HP:0008364)1.96032739
117Breech presentation (HP:0001623)1.95878972
118Broad long bones (HP:0005622)1.94759240
119Abnormality of the thoracic spine (HP:0100711)1.93100761
120Short hallux (HP:0010109)1.92147006
121Tarsal synostosis (HP:0008368)1.91593349
122Inguinal hernia (HP:0000023)1.90999640
123Increased variability in muscle fiber diameter (HP:0003557)1.89695724
124Thoracolumbar scoliosis (HP:0002944)1.89174327
125Vertebral hypoplasia (HP:0008417)1.88721999
126Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.88721999
127Long clavicles (HP:0000890)1.87745912
128Short 5th finger (HP:0009237)1.87387520
129Abnormality of the distal phalanx of the thumb (HP:0009617)1.86800841
130Delayed cranial suture closure (HP:0000270)1.85923722
131Round ear (HP:0100830)1.85892231
132Hip contracture (HP:0003273)1.85176538
133Alopecia of scalp (HP:0002293)1.85105587
134Asymmetry of the thorax (HP:0001555)1.84068235
135Back pain (HP:0003418)1.82570545
136Broad thumb (HP:0011304)1.80907335
137Broad toe (HP:0001837)1.80275615
138Absent frontal sinuses (HP:0002688)1.77433641
139Aplasia/Hypoplasia of the hallux (HP:0008362)1.77361022
140Lymphangioma (HP:0100764)1.76321421
141Persistence of primary teeth (HP:0006335)1.75879765
142Knee flexion contracture (HP:0006380)1.75309242
143Broad phalanx (HP:0006009)1.69129361
144Synostosis involving bones of the lower limbs (HP:0009138)1.68420193
145Synostosis involving bones of the feet (HP:0009140)1.68420193
146Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.68233554
147Buphthalmos (HP:0000557)1.67416476
148Disproportionate tall stature (HP:0001519)1.66633912
149Protruding ear (HP:0000411)1.66382524
150Mitral regurgitation (HP:0001653)1.65269289
151Neoplasm of the heart (HP:0100544)1.64700865
152Abnormality of skeletal muscle fiber size (HP:0012084)1.64284392
153Broad phalanges of the hand (HP:0009768)1.63608544
154Hypoplastic ischia (HP:0003175)1.63142430
155Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62190026
156Arachnodactyly (HP:0001166)1.61011510
157Broad finger (HP:0001500)1.60963425
158Trismus (HP:0000211)1.60546543
159Calcaneovalgus deformity (HP:0001848)1.60319501
160Distal upper limb amyotrophy (HP:0007149)1.57969052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.91162848
2MAP3K103.60022922
3PDGFRA3.52942129
4TRIB33.35196562
5DDR23.21998475
6MAP3K63.19194850
7TYK23.16902135
8TTN3.13540975
9LATS12.78413846
10EPHA22.60178863
11PKN22.57064911
12LATS22.54168531
13ERN12.52662038
14MST1R2.31783135
15EPHB22.29501928
16EEF2K2.25093702
17TIE12.21991450
18MAPK152.17208220
19MUSK2.12018197
20TGFBR22.08874627
21PAK42.04647132
22TNK21.81876569
23NME11.71828092
24JAK11.61422939
25PAK21.61298194
26CDK71.59092882
27ICK1.56142804
28MYLK1.55914449
29RIPK11.45506430
30TYRO31.42968072
31STK31.41426553
32KIT1.38008899
33TNIK1.37610110
34NEK21.33501523
35LRRK21.29859163
36RPS6KA41.28811809
37BMX1.25944322
38MET1.25251062
39MTOR1.23414049
40PTK61.21486410
41TGFBR11.21143452
42FGFR11.19385770
43FGFR21.16684867
44NLK1.15761530
45BRD41.14997166
46RPS6KB21.12397293
47PTK21.11786501
48TTK1.09956333
49STK38L1.07820356
50DMPK1.06911612
51FER1.05089911
52SIK10.99451719
53PDGFRB0.97681562
54ILK0.97057873
55CDK60.94863481
56TESK10.93145245
57BUB10.92909043
58CDC70.90013029
59CDK40.88843532
60EPHA30.87703972
61FLT30.87649194
62ERBB20.87642025
63PAK10.87484110
64NME20.87362906
65LIMK10.86256881
66MAPKAPK30.85079689
67WEE10.83683004
68RET0.79786225
69NUAK10.77089000
70LMTK20.77014656
71STK100.74485583
72MAP2K70.74386137
73PASK0.74283852
74NEK10.70010042
75MAP3K80.69466349
76CHEK20.67599078
77ROCK10.67169316
78STK40.65962709
79MAP2K60.65636109
80CDC42BPA0.65450451
81DAPK30.65410268
82MAPK110.65409175
83PRKD20.65116664
84FGFR40.65050745
85GSK3A0.63591102
86MARK20.62817214
87PLK10.62363410
88NTRK10.62210495
89RPS6KA20.61763742
90PAK30.61496801
91ABL20.61435139
92MOS0.60483323
93CHEK10.55871176
94BCR0.54995100
95MKNK10.52490882
96AKT30.52061664
97TRPM70.50954272
98MAP3K70.50888880
99PTK2B0.50863502
100AURKB0.50729647
101ATR0.48691464
102PRKG20.48010688
103PRKCI0.47906485
104ROCK20.47405731
105ALK0.46771782
106MAPK70.44783457
107FGFR30.44447383
108MAPK10.44337606
109INSRR0.43684593
110DYRK1B0.43542136
111BMPR1B0.42927427
112PLK30.42719959
113PIK3CG0.42650865
114SIK20.40713893
115STK380.40454582
116ATM0.39632360
117SCYL20.38343983
118DYRK30.37927972
119CDK20.37742869
120PRKD30.37636137
121RPS6KC10.37060079
122RPS6KL10.37060079
123AKT20.37029332
124CHUK0.36798843
125INSR0.36558026
126MAP2K10.35279932
127PRKD10.34512311
128ERBB30.34209024
129CSNK1D0.33880184
130MAP3K40.33820016
131SRC0.32896676
132RPS6KA60.32649684
133PIM10.32333979
134GRK10.32151185
135PIM20.31958602
136MAPK80.30199286
137CDK80.29773852
138PRKCE0.29251246
139HIPK20.29005604
140WNK40.28916477
141EPHB10.28872319
142AKT10.28557721
143MAPKAPK20.28113089
144CDK10.27432871
145KDR0.25980629
146NEK90.24599166

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.25806712
2Complement and coagulation cascades_Homo sapiens_hsa046103.20133458
3Other glycan degradation_Homo sapiens_hsa005113.05555153
4Basal cell carcinoma_Homo sapiens_hsa052172.79421889
5TGF-beta signaling pathway_Homo sapiens_hsa043502.52316972
6Focal adhesion_Homo sapiens_hsa045102.51444391
7Hippo signaling pathway_Homo sapiens_hsa043902.45977105
8Hedgehog signaling pathway_Homo sapiens_hsa043402.29432927
9Proteoglycans in cancer_Homo sapiens_hsa052052.29066772
10Cell cycle_Homo sapiens_hsa041102.06833940
11Adherens junction_Homo sapiens_hsa045202.02373519
12Small cell lung cancer_Homo sapiens_hsa052221.96778451
13MicroRNAs in cancer_Homo sapiens_hsa052061.94868042
14Notch signaling pathway_Homo sapiens_hsa043301.94787785
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.89749806
16p53 signaling pathway_Homo sapiens_hsa041151.87840597
17Bladder cancer_Homo sapiens_hsa052191.86341672
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.74099751
19Chronic myeloid leukemia_Homo sapiens_hsa052201.67942358
20Pertussis_Homo sapiens_hsa051331.67801502
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.67004406
22Protein digestion and absorption_Homo sapiens_hsa049741.65892644
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.62798717
24Amoebiasis_Homo sapiens_hsa051461.56185180
25Mismatch repair_Homo sapiens_hsa034301.54018431
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51739962
27Spliceosome_Homo sapiens_hsa030401.50616901
28PI3K-Akt signaling pathway_Homo sapiens_hsa041511.49815405
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.46836456
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.46761261
31RNA transport_Homo sapiens_hsa030131.44075795
32DNA replication_Homo sapiens_hsa030301.42223721
33Viral myocarditis_Homo sapiens_hsa054161.40406047
34HTLV-I infection_Homo sapiens_hsa051661.40140934
35Pathways in cancer_Homo sapiens_hsa052001.38319247
36Dilated cardiomyopathy_Homo sapiens_hsa054141.37506493
37Phototransduction_Homo sapiens_hsa047441.35762041
38Wnt signaling pathway_Homo sapiens_hsa043101.33982608
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32066066
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.30511023
41Colorectal cancer_Homo sapiens_hsa052101.28576240
42Melanoma_Homo sapiens_hsa052181.26446045
43Tight junction_Homo sapiens_hsa045301.23902133
44ABC transporters_Homo sapiens_hsa020101.17790575
45African trypanosomiasis_Homo sapiens_hsa051431.16943545
46Circadian rhythm_Homo sapiens_hsa047101.16673576
47Hepatitis C_Homo sapiens_hsa051601.16627760
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16094842
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15382380
50mRNA surveillance pathway_Homo sapiens_hsa030151.15347441
51Fat digestion and absorption_Homo sapiens_hsa049751.14040028
52Regulation of actin cytoskeleton_Homo sapiens_hsa048101.13428589
53Prostate cancer_Homo sapiens_hsa052151.10546802
54Base excision repair_Homo sapiens_hsa034101.05881230
55Pancreatic cancer_Homo sapiens_hsa052121.04749738
56Central carbon metabolism in cancer_Homo sapiens_hsa052301.04125680
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00830028
58Glioma_Homo sapiens_hsa052140.99974371
59Galactose metabolism_Homo sapiens_hsa000520.99896306
60mTOR signaling pathway_Homo sapiens_hsa041500.99371876
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97668227
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96376668
63Viral carcinogenesis_Homo sapiens_hsa052030.96188183
64One carbon pool by folate_Homo sapiens_hsa006700.95981135
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95703717
66Axon guidance_Homo sapiens_hsa043600.94258696
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.93953592
68Arginine and proline metabolism_Homo sapiens_hsa003300.90850796
69Lysine degradation_Homo sapiens_hsa003100.89734507
70Rap1 signaling pathway_Homo sapiens_hsa040150.89621087
71Mineral absorption_Homo sapiens_hsa049780.87051225
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86659410
73Sphingolipid metabolism_Homo sapiens_hsa006000.85612134
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85202441
75Ribosome_Homo sapiens_hsa030100.83048588
76Vitamin digestion and absorption_Homo sapiens_hsa049770.82054776
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81490508
78Endometrial cancer_Homo sapiens_hsa052130.81293307
79Choline metabolism in cancer_Homo sapiens_hsa052310.81250252
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79676037
81Staphylococcus aureus infection_Homo sapiens_hsa051500.79579543
82Thyroid cancer_Homo sapiens_hsa052160.79452560
83Sulfur relay system_Homo sapiens_hsa041220.78976407
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77067803
85Nucleotide excision repair_Homo sapiens_hsa034200.76852693
86Melanogenesis_Homo sapiens_hsa049160.75501621
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73423863
88Malaria_Homo sapiens_hsa051440.72649153
89Insulin resistance_Homo sapiens_hsa049310.68929848
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68739593
91Renal cell carcinoma_Homo sapiens_hsa052110.68738420
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68469235
93FoxO signaling pathway_Homo sapiens_hsa040680.67440910
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66857291
95Apoptosis_Homo sapiens_hsa042100.66202341
96Non-homologous end-joining_Homo sapiens_hsa034500.66015652
97HIF-1 signaling pathway_Homo sapiens_hsa040660.64940905
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.64466740
99Starch and sucrose metabolism_Homo sapiens_hsa005000.64077251
100Non-small cell lung cancer_Homo sapiens_hsa052230.63761726
101Influenza A_Homo sapiens_hsa051640.62668290
102Oocyte meiosis_Homo sapiens_hsa041140.61862902
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61785489
104Homologous recombination_Homo sapiens_hsa034400.61688129
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61651138
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60362984
107Toxoplasmosis_Homo sapiens_hsa051450.60084903
108Chemical carcinogenesis_Homo sapiens_hsa052040.57943376
109Hepatitis B_Homo sapiens_hsa051610.56467897
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55945937
111PPAR signaling pathway_Homo sapiens_hsa033200.54739242
112Ovarian steroidogenesis_Homo sapiens_hsa049130.54075139
113Shigellosis_Homo sapiens_hsa051310.53329232
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53105838
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.52702701
116GnRH signaling pathway_Homo sapiens_hsa049120.52663024
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.50694635
118Histidine metabolism_Homo sapiens_hsa003400.49474311
119VEGF signaling pathway_Homo sapiens_hsa043700.49288839
120Ras signaling pathway_Homo sapiens_hsa040140.48178132
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48094535
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47995740
123Renin-angiotensin system_Homo sapiens_hsa046140.47480373
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.47376039
125Platelet activation_Homo sapiens_hsa046110.47225846
126Insulin signaling pathway_Homo sapiens_hsa049100.46970090
127AMPK signaling pathway_Homo sapiens_hsa041520.46377891
128Arachidonic acid metabolism_Homo sapiens_hsa005900.45050693
129Antigen processing and presentation_Homo sapiens_hsa046120.45040954
130Acute myeloid leukemia_Homo sapiens_hsa052210.43997186
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.43908776
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43206157
133Glucagon signaling pathway_Homo sapiens_hsa049220.43026253
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42164408
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.41977498
136Thyroid hormone synthesis_Homo sapiens_hsa049180.41705109
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41164996
138Salmonella infection_Homo sapiens_hsa051320.41062918
139Herpes simplex infection_Homo sapiens_hsa051680.40938588
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.38940836
141N-Glycan biosynthesis_Homo sapiens_hsa005100.38371289
142Measles_Homo sapiens_hsa051620.38003868
143Fanconi anemia pathway_Homo sapiens_hsa034600.37727125
144Gap junction_Homo sapiens_hsa045400.37607182
145Caffeine metabolism_Homo sapiens_hsa002320.36866593
146Folate biosynthesis_Homo sapiens_hsa007900.36702593
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36217057
148Lysosome_Homo sapiens_hsa041420.36006869
149Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35941044
150Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35805869
151Adipocytokine signaling pathway_Homo sapiens_hsa049200.35246640
152Glutathione metabolism_Homo sapiens_hsa004800.35152422

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