MMP12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.73696125
2adhesion of symbiont to host cell (GO:0044650)6.49963469
3virion attachment to host cell (GO:0019062)6.49963469
4neutrophil activation involved in immune response (GO:0002283)6.47793699
5positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)6.35680109
6adhesion of symbiont to host (GO:0044406)5.65502493
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.39718017
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.39718017
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.39718017
10modulation by symbiont of host immune response (GO:0052553)5.39718017
11positive regulation by symbiont of host defense response (GO:0052509)5.39718017
12modulation by symbiont of host defense response (GO:0052031)5.39718017
13respiratory burst (GO:0045730)5.16078954
14regulation of syncytium formation by plasma membrane fusion (GO:0060142)5.09774131
15phagocytosis, recognition (GO:0006910)5.06266463
16eosinophil chemotaxis (GO:0048245)4.90675608
17hydrogen peroxide biosynthetic process (GO:0050665)4.88716136
18superoxide anion generation (GO:0042554)4.81119422
19granulocyte activation (GO:0036230)4.65208598
20glycosphingolipid catabolic process (GO:0046479)4.60662550
21cellular extravasation (GO:0045123)4.59125668
22positive regulation of monocyte chemotaxis (GO:0090026)4.58770974
23regulation of interferon-beta biosynthetic process (GO:0045357)4.52339642
24positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610814.44309384
25macrophage activation involved in immune response (GO:0002281)4.44028964
26production of molecular mediator involved in inflammatory response (GO:0002532)4.42236490
27regulation of mononuclear cell migration (GO:0071675)4.38821734
28eosinophil migration (GO:0072677)4.33611899
29reactive oxygen species biosynthetic process (GO:1903409)4.31419924
30complement activation, classical pathway (GO:0006958)4.28998226
31immunoglobulin mediated immune response (GO:0016064)4.28638114
32positive regulation of mast cell activation (GO:0033005)4.28164135
33positive regulation of interferon-alpha production (GO:0032727)4.27144713
34positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.26931696
35neutrophil activation (GO:0042119)4.21095684
36glycolipid catabolic process (GO:0019377)4.17700394
37negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.15049413
38response to peptidoglycan (GO:0032494)4.03565810
39natural killer cell mediated immunity (GO:0002228)4.02899326
40natural killer cell mediated cytotoxicity (GO:0042267)4.02899326
41positive regulation of mast cell degranulation (GO:0043306)4.01349398
42positive regulation of mast cell activation involved in immune response (GO:0033008)4.01349398
43regulation of interferon-alpha production (GO:0032647)3.99208494
44positive regulation of macrophage cytokine production (GO:0060907)3.98353045
45regulation of dendritic cell antigen processing and presentation (GO:0002604)3.95239108
46myeloid cell activation involved in immune response (GO:0002275)3.94301583
47phagosome maturation (GO:0090382)3.92281310
48cellular response to zinc ion (GO:0071294)3.90034393
49regulation of cholesterol storage (GO:0010885)3.88655908
50positive regulation of chemokine biosynthetic process (GO:0045080)3.85675287
51lipopolysaccharide-mediated signaling pathway (GO:0031663)3.82373875
52interferon-gamma-mediated signaling pathway (GO:0060333)3.80818265
53monocyte chemotaxis (GO:0002548)3.77062456
54positive regulation of cellular amide metabolic process (GO:0034250)3.70860256
55ceramide catabolic process (GO:0046514)3.67879938
56low-density lipoprotein particle clearance (GO:0034383)3.61754780
57pinocytosis (GO:0006907)3.57508127
58regulation of antigen processing and presentation (GO:0002577)3.55839007
59myeloid dendritic cell differentiation (GO:0043011)3.55371253
60regulation of mast cell degranulation (GO:0043304)3.51203757
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.49406726
62response to host immune response (GO:0052572)3.49406726
63regulation of mast cell activation (GO:0033003)3.49324942
64angiotensin maturation (GO:0002003)3.49084689
65antigen processing and presentation of endogenous antigen (GO:0019883)3.48862503
66oligosaccharide catabolic process (GO:0009313)3.46625173
67defense response to protozoan (GO:0042832)3.45492839
68regulation of monocyte chemotaxis (GO:0090025)3.44808539
69positive regulation of bone remodeling (GO:0046852)3.43612975
70positive regulation of bone resorption (GO:0045780)3.43612975
71myeloid dendritic cell activation (GO:0001773)3.42674479
72complement activation (GO:0006956)3.41791997
73positive regulation of type 2 immune response (GO:0002830)3.41417965
74glomerular filtration (GO:0003094)3.35669679
75germinal center formation (GO:0002467)3.32690921
76negative regulation of interleukin-17 production (GO:0032700)3.31676740
77macrophage activation (GO:0042116)3.28603208
78regulation of T-helper 1 cell differentiation (GO:0045625)3.26562359
79regulation of mast cell activation involved in immune response (GO:0033006)3.25311336
80positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.22764605
81detection of molecule of bacterial origin (GO:0032490)3.22494182
82apoptotic cell clearance (GO:0043277)3.22362656
83positive regulation of leukocyte degranulation (GO:0043302)3.20939691
84regulation of chemokine biosynthetic process (GO:0045073)3.20731063
85microglial cell activation (GO:0001774)3.20519011
86positive regulation of antigen processing and presentation (GO:0002579)3.18225451
87positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.17529557
88positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.17523945
89antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16232554
90mannose metabolic process (GO:0006013)3.15311910
91B cell mediated immunity (GO:0019724)3.12083310
92cellular response to interferon-gamma (GO:0071346)3.11537954
93neutrophil chemotaxis (GO:0030593)3.11503666
94regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.11317665
95macrophage chemotaxis (GO:0048246)3.10599904
96regulation of apoptotic cell clearance (GO:2000425)3.10474171
97regulation of vitamin D biosynthetic process (GO:0060556)3.10327405
98response to muramyl dipeptide (GO:0032495)3.09073871
99positive regulation of interferon-beta production (GO:0032728)3.07662820
100positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.06801770
101positive regulation of gamma-delta T cell activation (GO:0046645)3.06282708
102negative regulation of mast cell activation (GO:0033004)3.06282699
103myeloid leukocyte activation (GO:0002274)3.05993362
104barbed-end actin filament capping (GO:0051016)3.05959520
105sphingolipid catabolic process (GO:0030149)3.05795794
106antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05482834
107detection of other organism (GO:0098543)3.05120545
108positive regulation of interleukin-12 production (GO:0032735)3.05087219
109negative regulation of myeloid cell apoptotic process (GO:0033033)3.03984410
110detection of bacterium (GO:0016045)3.03845407
111membrane lipid catabolic process (GO:0046466)3.03709089
112positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.03484264
113neutrophil migration (GO:1990266)3.02889984
114dendritic cell differentiation (GO:0097028)3.02186000
115renal filtration (GO:0097205)3.02124375
116positive regulation of lipid storage (GO:0010884)3.01052182
117regulation of T-helper 2 cell differentiation (GO:0045628)3.00653208
118regulation of vitamin metabolic process (GO:0030656)3.00652595
119response to host defenses (GO:0052200)2.98383443
120response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.98383443
121response to host (GO:0075136)2.98383443
122peptide catabolic process (GO:0043171)2.97391388
123response to interferon-gamma (GO:0034341)2.96491519
124cellular response to thyroid hormone stimulus (GO:0097067)2.95997149
125lymphocyte chemotaxis (GO:0048247)2.95925130
126positive regulation of interleukin-6 production (GO:0032755)2.95541120
127leukocyte mediated cytotoxicity (GO:0001909)2.92386187
128positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.91919748
129regulation of type 2 immune response (GO:0002828)2.91275403
130negative regulation of interleukin-12 production (GO:0032695)2.91167540
131regulation of hypersensitivity (GO:0002883)2.90490312
132regulation of interleukin-8 biosynthetic process (GO:0045414)2.90296293
133superoxide metabolic process (GO:0006801)2.89514609
134response to protozoan (GO:0001562)2.88596201
135positive regulation of lymphocyte migration (GO:2000403)2.88366367
136regulation of leukocyte degranulation (GO:0043300)2.87664836
137regulation of macrophage cytokine production (GO:0010935)2.86803936
138lipoxygenase pathway (GO:0019372)2.86344127
139T-helper 1 type immune response (GO:0042088)2.85865907
140regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85389037
141regulation of myeloid leukocyte mediated immunity (GO:0002886)2.84712833
142positive regulation of heat generation (GO:0031652)2.84041224
143positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.81873580
144regulation of inflammatory response to antigenic stimulus (GO:0002861)2.81694120
145positive regulation of tumor necrosis factor production (GO:0032760)2.81479738
146positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80970559
147positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.79055439
148type I interferon signaling pathway (GO:0060337)2.75683915
149cellular response to type I interferon (GO:0071357)2.75683915
150regulation of cellular extravasation (GO:0002691)2.73914043
151regulation of interleukin-2 biosynthetic process (GO:0045076)2.73247768
152response to type I interferon (GO:0034340)2.72083284
153T cell costimulation (GO:0031295)2.70204672
154Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.69307612
155regulation of transforming growth factor beta1 production (GO:0032908)2.67696620
156dendritic cell chemotaxis (GO:0002407)2.67472927
157lymphocyte costimulation (GO:0031294)2.65750020
158NIK/NF-kappaB signaling (GO:0038061)2.65172250
159protein localization to endosome (GO:0036010)2.64988987
160positive regulation of neutrophil chemotaxis (GO:0090023)2.64829430
161positive regulation of neutrophil migration (GO:1902624)2.64829430
162immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.64058818
163Fc-gamma receptor signaling pathway (GO:0038094)2.64058818
164Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.64058818
165regulation of T cell tolerance induction (GO:0002664)2.59286458
166positive regulation of respiratory burst (GO:0060267)2.57912074
167osteoclast differentiation (GO:0030316)2.57470555
168positive regulation of tissue remodeling (GO:0034105)2.56210477
169detection of external biotic stimulus (GO:0098581)2.55566807
170regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.54865196
171amino sugar catabolic process (GO:0046348)2.54095831
172positive regulation of T-helper cell differentiation (GO:0045624)2.51846613
173regulation of gamma-delta T cell activation (GO:0046643)2.51765559

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.89746593
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.36805008
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.81881452
4* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.91355971
5* IRF8_27001747_Chip-Seq_BMDM_Mouse4.63551703
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.30196345
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.85939918
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.60121000
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.18925362
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13683701
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.01873787
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.91043060
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.88783695
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.65083420
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.63133137
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.51818075
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20462850
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.19139439
19PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.11733951
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01565270
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99779698
22SPI1_23547873_ChIP-Seq_NB4_Human1.99163830
23PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.94779456
24VDR_24787735_ChIP-Seq_THP-1_Human1.94298913
25* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.75258760
26PU_27001747_Chip-Seq_BMDM_Mouse1.74041530
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70159491
28* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69258216
29NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.58462171
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.58462171
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56594318
32* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.52904364
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.48666913
34SPI1_23127762_ChIP-Seq_K562_Human1.42936099
35* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42681674
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41706333
37RUNX_20019798_ChIP-Seq_JUKART_Human1.38427910
38VDR_24763502_ChIP-Seq_THP-1_Human1.35720689
39EGR1_19032775_ChIP-ChIP_M12_Human1.35582241
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35522725
41* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34688646
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32400513
43CLOCK_20551151_ChIP-Seq_293T_Human1.30681830
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30560009
45* MYB_26560356_Chip-Seq_TH2_Human1.29759151
46LXR_22292898_ChIP-Seq_THP-1_Human1.28230698
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27383015
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25114621
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22502328
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21379457
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20961108
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20908003
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19773743
54GATA1_19941826_ChIP-Seq_K562_Human1.19046252
55VDR_21846776_ChIP-Seq_THP-1_Human1.18471614
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.15319579
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.15253205
58GATA3_26560356_Chip-Seq_TH2_Human1.12846110
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12270726
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10977224
61* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09603777
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09243515
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.07433216
64GATA3_27048872_Chip-Seq_THYMUS_Human1.05050505
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04871844
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04739439
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.02096910
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02003609
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01343981
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01315211
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97157072
72LXR_22158963_ChIP-Seq_LIVER_Mouse0.96482901
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96212300
74GATA1_22025678_ChIP-Seq_K562_Human0.96103526
75SOX2_20726797_ChIP-Seq_SW620_Human0.95455880
76SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94376763
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93540979
78CJUN_26792858_Chip-Seq_BT549_Human0.93464252
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92689557
80MYB_26560356_Chip-Seq_TH1_Human0.92662177
81MAF_26560356_Chip-Seq_TH1_Human0.92627899
82PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92324965
83GATA2_19941826_ChIP-Seq_K562_Human0.90819207
84RXR_22158963_ChIP-Seq_LIVER_Mouse0.90447242
85GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90062734
86CDX2_20551321_ChIP-Seq_CACO-2_Human0.89806878
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88981721
88TRIM28_21343339_ChIP-Seq_HEK293_Human0.88924341
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88295848
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87916993
91TFEB_21752829_ChIP-Seq_HELA_Human0.87266525
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86179947
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85252590
94SCL_19346495_ChIP-Seq_HPC-7_Human0.84869901
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84334495
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83944423
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83944423
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82417698
99JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81307450
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80401489
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79224275
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78445092
103SMAD_19615063_ChIP-ChIP_OVARY_Human0.77066737
104UTX_26944678_Chip-Seq_JUKART_Human0.76676112
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76634013
106RACK7_27058665_Chip-Seq_MCF-7_Human0.76416652
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75532009
108* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74934259
109E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.73329875
110KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.73024921
111SMRT_27268052_Chip-Seq_Bcells_Human0.72993852
112FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.72974008
113SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70175118
114P63_26484246_Chip-Seq_KERATINOCYTES_Human0.68840925
115TP53_18474530_ChIP-ChIP_U2OS_Human0.67709360
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.67569358
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65545494
118EGR1_23403033_ChIP-Seq_LIVER_Mouse0.65390665
119* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.64755900
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.63682527
121RARG_19884340_ChIP-ChIP_MEFs_Mouse0.61080498
122TP63_17297297_ChIP-ChIP_HaCaT_Human0.59873835
123* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.59316118
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.56754701
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.56151755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.77883529
2MP0003303_peritoneal_inflammation4.35623681
3MP0003436_decreased_susceptibility_to4.30036065
4MP0006082_CNS_inflammation4.20766125
5MP0002148_abnormal_hypersensitivity_rea3.92830209
6MP0009785_altered_susceptibility_to3.62039947
7* MP0002419_abnormal_innate_immunity3.45603151
8MP0005000_abnormal_immune_tolerance3.33370709
9* MP0005025_abnormal_response_to3.03393109
10MP0003724_increased_susceptibility_to2.90405138
11MP0005058_abnormal_lysosome_morphology2.84225241
12MP0005671_abnormal_response_to2.68748397
13* MP0002452_abnormal_antigen_presenting2.64259908
14MP0008004_abnormal_stomach_pH2.56960241
15MP0002723_abnormal_immune_serum2.41117706
16MP0001853_heart_inflammation2.27841162
17MP0004510_myositis2.23757283
18MP0005387_immune_system_phenotype2.21740532
19MP0001790_abnormal_immune_system2.21740532
20MP0003690_abnormal_glial_cell2.16281518
21* MP0001819_abnormal_immune_cell2.14817271
22MP0001800_abnormal_humoral_immune2.14269843
23MP0000685_abnormal_immune_system2.11281430
24* MP0002420_abnormal_adaptive_immunity2.09834588
25MP0005464_abnormal_platelet_physiology2.08888563
26MP0001533_abnormal_skeleton_physiology2.07289672
27MP0002405_respiratory_system_inflammati2.05471546
28MP0003448_altered_tumor_morphology2.02251980
29MP0000343_altered_response_to2.00727533
30MP0000569_abnormal_digit_pigmentation1.98790479
31MP0010234_abnormal_vibrissa_follicle1.95455782
32MP0003172_abnormal_lysosome_physiology1.89436443
33MP0009764_decreased_sensitivity_to1.89367358
34MP0001845_abnormal_inflammatory_respons1.86537866
35MP0003075_altered_response_to1.84699294
36MP0010386_abnormal_urinary_bladder1.84607481
37MP0002998_abnormal_bone_remodeling1.77136724
38MP0002139_abnormal_hepatobiliary_system1.75671537
39MP0003191_abnormal_cellular_cholesterol1.68648984
40MP0004947_skin_inflammation1.61992813
41MP0005310_abnormal_salivary_gland1.58829894
42MP0008469_abnormal_protein_level1.56343807
43MP0000604_amyloidosis1.56189790
44MP0010155_abnormal_intestine_physiology1.51526830
45* MP0005166_decreased_susceptibility_to1.45547265
46MP0005257_abnormal_intraocular_pressure1.45363628
47MP0009333_abnormal_splenocyte_physiolog1.44886959
48MP0000716_abnormal_immune_system1.41322983
49MP0001851_eye_inflammation1.40980988
50MP0003186_abnormal_redox_activity1.39307114
51MP0000858_altered_metastatic_potential1.37287154
52MP0005164_abnormal_response_to1.30816966
53MP0005647_abnormal_sex_gland1.25637194
54MP0003806_abnormal_nucleotide_metabolis1.25060075
55MP0002006_tumorigenesis1.23610277
56MP0003828_pulmonary_edema1.22568066
57MP0002877_abnormal_melanocyte_morpholog1.22329713
58MP0005174_abnormal_tail_pigmentation1.21770993
59MP0004782_abnormal_surfactant_physiolog1.20017620
60MP0002398_abnormal_bone_marrow1.17000044
61MP0005397_hematopoietic_system_phenotyp1.14621733
62MP0001545_abnormal_hematopoietic_system1.14621733
63MP0003329_amyloid_beta_deposits1.13073886
64MP0004130_abnormal_muscle_cell1.09327107
65MP0002429_abnormal_blood_cell1.09117594
66MP0001849_ear_inflammation1.05834750
67MP0005167_abnormal_blood-brain_barrier1.04794931
68MP0000465_gastrointestinal_hemorrhage1.04581278
69MP0003656_abnormal_erythrocyte_physiolo1.02789624
70MP0005023_abnormal_wound_healing1.02363134
71MP0000689_abnormal_spleen_morphology0.99471525
72MP0009763_increased_sensitivity_to0.99456307
73MP0005165_increased_susceptibility_to0.99259635
74MP0002090_abnormal_vision0.98630507
75MP0005390_skeleton_phenotype0.96749767
76MP0009840_abnormal_foam_cell0.96424062
77MP0003866_abnormal_defecation0.94863237
78MP0001542_abnormal_bone_strength0.94844811
79MP0008260_abnormal_autophagy0.93970809
80MP0004264_abnormal_extraembryonic_tissu0.93358079
81MP0010307_abnormal_tumor_latency0.93100671
82MP0000371_diluted_coat_color0.92604657
83MP0002254_reproductive_system_inflammat0.91774691
84MP0003195_calcinosis0.90765391
85MP0005451_abnormal_body_composition0.90210039
86MP0002722_abnormal_immune_system0.89079111
87MP0005365_abnormal_bile_salt0.86505711
88MP0002971_abnormal_brown_adipose0.82785016
89MP0009115_abnormal_fat_cell0.81690861
90MP0009278_abnormal_bone_marrow0.79544129
91MP0002896_abnormal_bone_mineralization0.79521387
92MP0003566_abnormal_cell_adhesion0.79186509
93MP0000372_irregular_coat_pigmentation0.78300017
94MP0002933_joint_inflammation0.76885446
95MP0003795_abnormal_bone_structure0.76372680
96MP0009765_abnormal_xenobiotic_induced0.76265690
97MP0001873_stomach_inflammation0.75131672
98MP0004883_abnormal_blood_vessel0.75098624
99MP0000015_abnormal_ear_pigmentation0.74091407
100MP0001663_abnormal_digestive_system0.73093949
101MP0003183_abnormal_peptide_metabolism0.70353549
102MP0005275_abnormal_skin_tensile0.70011878
103MP0005319_abnormal_enzyme/_coenzyme0.69696904
104MP0002136_abnormal_kidney_physiology0.69310658
105* MP0000920_abnormal_myelination0.67049272
106MP0003705_abnormal_hypodermis_morpholog0.66723859
107MP0003453_abnormal_keratinocyte_physiol0.66568837
108MP0000249_abnormal_blood_vessel0.65498580
109MP0005171_absent_coat_pigmentation0.63834820
110MP0005076_abnormal_cell_differentiation0.59620337
111MP0010352_gastrointestinal_tract_polyps0.58448017
112MP0003136_yellow_coat_color0.58304426
113MP0003300_gastrointestinal_ulcer0.57497655
114MP0001727_abnormal_embryo_implantation0.53489672
115MP0003091_abnormal_cell_migration0.52120986
116MP0002277_abnormal_respiratory_mucosa0.51427042
117MP0002332_abnormal_exercise_endurance0.50900067
118MP0002138_abnormal_hepatobiliary_system0.50360471
119MP0001958_emphysema0.49252412
120MP0008438_abnormal_cutaneous_collagen0.48991104
121MP0002295_abnormal_pulmonary_circulatio0.46093929
122MP0005197_abnormal_uvea_morphology0.45186175

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)8.02812754
2Eczematoid dermatitis (HP:0000976)8.02616805
3Recurrent abscess formation (HP:0002722)7.98661628
4Recurrent bacterial skin infections (HP:0005406)7.16528141
5Abnormality of macrophages (HP:0004311)5.94806355
6Vacuolated lymphocytes (HP:0001922)5.74387375
7Mediastinal lymphadenopathy (HP:0100721)5.43756105
8Increased cerebral lipofuscin (HP:0011813)5.22863116
9Gingivitis (HP:0000230)4.65028421
10Recurrent skin infections (HP:0001581)4.60955312
11Chronic obstructive pulmonary disease (HP:0006510)4.55943260
12Obstructive lung disease (HP:0006536)4.55943260
13Axonal loss (HP:0003447)4.42164487
14Increased neuronal autofluorescent lipopigment (HP:0002074)4.33432009
15Abnormality of liposaccharide metabolism (HP:0010968)4.18759289
16Abnormality of glycosphingolipid metabolism (HP:0004343)4.18759289
17Abnormality of glycolipid metabolism (HP:0010969)4.18759289
18Disinhibition (HP:0000734)4.17968719
19Stomatitis (HP:0010280)4.08781637
20Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.03251533
21Recurrent fungal infections (HP:0002841)4.01631784
22Protuberant abdomen (HP:0001538)3.62735831
23Autoimmune thrombocytopenia (HP:0001973)3.59114571
24Recurrent cutaneous fungal infections (HP:0011370)3.57955841
25Chronic mucocutaneous candidiasis (HP:0002728)3.57955841
26Myositis (HP:0100614)3.40684371
27Basal ganglia calcification (HP:0002135)3.35262232
28Systemic lupus erythematosus (HP:0002725)3.34526696
29Elevated erythrocyte sedimentation rate (HP:0003565)3.19874339
30Optic neuritis (HP:0100653)3.16281818
31Retrobulbar optic neuritis (HP:0100654)3.16281818
32Orchitis (HP:0100796)3.15086938
33Myocardial infarction (HP:0001658)3.09465672
34Cellulitis (HP:0100658)3.08244114
35Prostate neoplasm (HP:0100787)3.05147747
36Agnosia (HP:0010524)3.05121224
37Dysostosis multiplex (HP:0000943)2.97308981
38Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.93755164
39Vasculitis (HP:0002633)2.91171814
40Urticaria (HP:0001025)2.88863753
41Hepatosplenomegaly (HP:0001433)2.83850123
42Periodontitis (HP:0000704)2.83305493
43Loss of speech (HP:0002371)2.83054586
44Interstitial pulmonary disease (HP:0006530)2.79494513
45Mutism (HP:0002300)2.77559953
46Recurrent pneumonia (HP:0006532)2.75339777
47Complement deficiency (HP:0004431)2.74197253
48Recurrent viral infections (HP:0004429)2.71639395
49Joint hemorrhage (HP:0005261)2.70847883
50Malnutrition (HP:0004395)2.70205813
51Increased IgM level (HP:0003496)2.70052955
52Nausea (HP:0002018)2.66019972
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.63884498
54Osteolytic defects of the hand bones (HP:0009699)2.63884498
55Abnormality of complement system (HP:0005339)2.61633732
56Steatorrhea (HP:0002570)2.59672436
57Hemoptysis (HP:0002105)2.57230063
58Spontaneous hematomas (HP:0007420)2.56474314
59Osteomyelitis (HP:0002754)2.56357896
60Thick nail (HP:0001805)2.55222156
61Upper motor neuron abnormality (HP:0002127)2.54574660
62Cheilitis (HP:0100825)2.53392729
63Poor head control (HP:0002421)2.51743339
64Thin bony cortex (HP:0002753)2.50098077
65Spondylolisthesis (HP:0003302)2.48329295
66Polygenic inheritance (HP:0010982)2.47264267
67Colitis (HP:0002583)2.46401020
68Amyloidosis (HP:0011034)2.46056254
69Pulmonary infiltrates (HP:0002113)2.44349078
70Meningitis (HP:0001287)2.43966514
71Abnormality of the vasculature of the conjunctiva (HP:0008054)2.32865298
72Urinary glycosaminoglycan excretion (HP:0003541)2.32625141
73Mucopolysacchariduria (HP:0008155)2.32625141
74Hematochezia (HP:0002573)2.29627712
75Pustule (HP:0200039)2.27016067
76Sepsis (HP:0100806)2.26428971
77Thoracic kyphosis (HP:0002942)2.25564522
78Fat malabsorption (HP:0002630)2.25140116
79Multiple lipomas (HP:0001012)2.23266018
80Recurrent lower respiratory tract infections (HP:0002783)2.23126459
81Inappropriate behavior (HP:0000719)2.22971805
82Leukocytosis (HP:0001974)2.20729689
83Gingival bleeding (HP:0000225)2.19689419
84Abdominal distention (HP:0003270)2.17606269
85Peripheral demyelination (HP:0011096)2.17421117
86Glomerulonephritis (HP:0000099)2.15806267
87Abnormality of polysaccharide metabolism (HP:0011012)2.15542678
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15542678
89Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15542678
90Metaphyseal irregularity (HP:0003025)2.11570724
91Arterial thrombosis (HP:0004420)2.11173951
92Gangrene (HP:0100758)2.10470093
93Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.09762437
94Bone pain (HP:0002653)2.09579876
95Inflammation of the large intestine (HP:0002037)2.09009062
96Pathologic fracture (HP:0002756)2.07332086
97Xerostomia (HP:0000217)2.03620739
98Nuclear cataract (HP:0100018)2.02343786
99Segmental peripheral demyelination/remyelination (HP:0003481)2.01806552
100Hypercholesterolemia (HP:0003124)2.01266243
101Tetraparesis (HP:0002273)2.01229107
102Asymmetric septal hypertrophy (HP:0001670)2.00599092
103Diminished motivation (HP:0000745)2.00578448
104Petechiae (HP:0000967)1.98727085
105Femoral bowing (HP:0002980)1.98152595
106Hypergammaglobulinemia (HP:0010702)1.94588207
107Gastrointestinal inflammation (HP:0004386)1.94515521
108Abnormality of T cell number (HP:0011839)1.93848375
109Albinism (HP:0001022)1.93654385
110Gastrointestinal infarctions (HP:0005244)1.92759141
111Neurofibrillary tangles (HP:0002185)1.91991630
112Esophageal varix (HP:0002040)1.91685520
113Apathy (HP:0000741)1.91668173
114Restrictive lung disease (HP:0002091)1.90682836
115Amaurosis fugax (HP:0100576)1.89470407
116Conjunctival telangiectasia (HP:0000524)1.88548663
117Premature loss of primary teeth (HP:0006323)1.86396512
118Abnormality of the peritoneum (HP:0002585)1.86104636
119Prolonged bleeding time (HP:0003010)1.85448672
120Purpura (HP:0000979)1.84858658
121Mucosal telangiectasiae (HP:0100579)1.84455111
122Neuronal loss in central nervous system (HP:0002529)1.78189148
123Abnormality of the lumbar spine (HP:0100712)1.77992112
124Gastrointestinal stroma tumor (HP:0100723)1.77444720
125Pulmonary hypertension (HP:0002092)1.77336814
126Bone cyst (HP:0012062)1.76672463
127Arthralgia (HP:0002829)1.76650884
128T lymphocytopenia (HP:0005403)1.76164176
129Abnormality of the pericardium (HP:0001697)1.76018744
130Abnormality of the prostate (HP:0008775)1.75701581
131Personality changes (HP:0000751)1.74281037
132Progressive visual loss (HP:0000529)1.71868497
133Anorexia (HP:0002039)1.69332878
134Nephritis (HP:0000123)1.66566109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK6.78836186
2RIPK45.70923042
3BLK3.94171750
4MAP3K143.69358602
5NME23.28336372
6TBK13.08408257
7IRAK42.67796141
8CDC42BPA2.32448457
9IRAK32.30597376
10PRPF4B2.25416111
11PIM22.25349475
12MST1R2.15740210
13ABL22.10179331
14NEK92.08172574
15IKBKB2.04208359
16TYK21.87320372
17TXK1.82524807
18MAP4K11.82360398
19KIT1.80265456
20JAK31.64590462
21ERBB31.58466116
22GRK71.52520222
23BMX1.50630896
24TRPM71.47126283
25MST41.45445656
26DDR21.43086921
27IKBKE1.41889384
28JAK11.39867072
29BMPR21.32115166
30FGFR41.31817527
31SYK1.31394215
32STK41.27514829
33MAP3K131.20151322
34LYN1.19848853
35HCK1.15628625
36EPHA31.14209854
37MARK31.14204224
38CSK1.13317415
39TAOK31.12245065
40ERN11.10249644
41JAK21.08429787
42FGR1.06305923
43ZAP701.05824932
44MAP3K31.03850984
45ERBB41.02483669
46PIK3CG1.01685406
47CAMKK21.01593232
48RIPK11.01336752
49YES11.00787075
50ADRBK20.99318341
51PIM10.98665998
52CAMK1D0.98396357
53CHUK0.97163880
54LCK0.94815132
55BTK0.91749542
56TEC0.91113322
57PRKG20.88974688
58MATK0.88482395
59STK240.87444824
60CSF1R0.86373035
61PDK20.82993969
62RPS6KA20.82913295
63ABL10.82770240
64LIMK10.76568156
65PRKCD0.75344440
66PDGFRA0.74769798
67TESK20.72739155
68RPS6KA40.70693121
69TRIB30.68794239
70EGFR0.67430956
71SCYL20.67393470
72TAOK10.66468372
73MAP3K60.62416071
74CAMK1G0.62312592
75CDK60.61988133
76MAP3K50.61599839
77FER0.60095094
78SIK30.55753538
79MAP3K110.54392397
80IRAK20.54093021
81MUSK0.53592912
82MAP3K100.53592476
83MAPK70.52545164
84DAPK30.52378220
85MAPKAPK20.51876127
86FES0.51760498
87PAK40.50799381
88PRKCQ0.49802312
89CLK10.49134752
90EIF2AK20.48906391
91BMPR1B0.47616851
92RPS6KC10.46549683
93RPS6KL10.46549683
94MAP3K80.45693805
95PRKCH0.45372274
96PDGFRB0.45054569
97CAMKK10.44734039
98RET0.44641156
99IRAK10.44016583
100FGFR30.43278449
101MET0.40758320
102PKN20.40460195
103PDPK10.38872413
104GSK3A0.38087977
105DAPK20.37079972
106MAP3K20.36463751
107PDK10.36305094
108FYN0.35180956
109ITK0.34712580
110TTN0.33323436
111MOS0.32022076
112STK100.29646068
113ARAF0.29328689
114IGF1R0.28834877
115TESK10.28624768
116TGFBR20.28128637
117SIK20.26563665
118EPHB10.24611064
119ACVR1B0.24131480
120MAP3K120.23785813
121KSR20.22489961
122MAP3K10.21753641
123LRRK20.20413555
124SRC0.20389089
125DYRK1B0.19717130
126INSR0.18561759
127MAP2K30.17942395
128TAOK20.17577791
129PLK20.17348542
130PRKCE0.17336821
131STK30.13758268

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.33783510
2Graft-versus-host disease_Homo sapiens_hsa053323.27945970
3Rheumatoid arthritis_Homo sapiens_hsa053233.17553100
4Phagosome_Homo sapiens_hsa041452.88060442
5Tuberculosis_Homo sapiens_hsa051522.78118250
6Lysosome_Homo sapiens_hsa041422.71616678
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.65182614
8Legionellosis_Homo sapiens_hsa051342.61727875
9Collecting duct acid secretion_Homo sapiens_hsa049662.57576485
10Staphylococcus aureus infection_Homo sapiens_hsa051502.55248574
11Malaria_Homo sapiens_hsa051442.47718352
12Allograft rejection_Homo sapiens_hsa053302.38688155
13Osteoclast differentiation_Homo sapiens_hsa043802.34209011
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.30595555
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.29979172
16NOD-like receptor signaling pathway_Homo sapiens_hsa046212.26606388
17Pertussis_Homo sapiens_hsa051332.23769219
18Asthma_Homo sapiens_hsa053102.12565690
19Salmonella infection_Homo sapiens_hsa051321.97491583
20Type I diabetes mellitus_Homo sapiens_hsa049401.97228449
21Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.83739530
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76971518
23TNF signaling pathway_Homo sapiens_hsa046681.65946024
24Hematopoietic cell lineage_Homo sapiens_hsa046401.56153854
25Measles_Homo sapiens_hsa051621.55523193
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54478649
27Other glycan degradation_Homo sapiens_hsa005111.54318871
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43660845
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.41878514
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.38821226
31Chemokine signaling pathway_Homo sapiens_hsa040621.36602733
32Influenza A_Homo sapiens_hsa051641.36488551
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32368417
34African trypanosomiasis_Homo sapiens_hsa051431.27766150
35B cell receptor signaling pathway_Homo sapiens_hsa046621.27400511
36Toxoplasmosis_Homo sapiens_hsa051451.23043602
37Vibrio cholerae infection_Homo sapiens_hsa051101.22953258
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22388175
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22380303
40Apoptosis_Homo sapiens_hsa042101.19723176
41Shigellosis_Homo sapiens_hsa051311.19013829
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18965884
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17542848
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10193785
45Complement and coagulation cascades_Homo sapiens_hsa046101.09970180
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.06079731
47Viral myocarditis_Homo sapiens_hsa054161.02466684
48Autoimmune thyroid disease_Homo sapiens_hsa053201.01578872
49Antigen processing and presentation_Homo sapiens_hsa046121.01178062
50Steroid biosynthesis_Homo sapiens_hsa001001.00716314
51Galactose metabolism_Homo sapiens_hsa000520.93507699
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92027580
53Amoebiasis_Homo sapiens_hsa051460.91027828
54Herpes simplex infection_Homo sapiens_hsa051680.87697630
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86931749
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.83818319
57Sulfur metabolism_Homo sapiens_hsa009200.83775089
58Synaptic vesicle cycle_Homo sapiens_hsa047210.82397624
59Hepatitis B_Homo sapiens_hsa051610.78491962
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77118550
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74438551
62Fructose and mannose metabolism_Homo sapiens_hsa000510.73189617
63Primary immunodeficiency_Homo sapiens_hsa053400.70550286
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67123469
65Hepatitis C_Homo sapiens_hsa051600.64231781
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58564385
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58156779
68Sphingolipid metabolism_Homo sapiens_hsa006000.57552121
69Platelet activation_Homo sapiens_hsa046110.57365343
70T cell receptor signaling pathway_Homo sapiens_hsa046600.56748577
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55648656
72Prion diseases_Homo sapiens_hsa050200.54328777
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53740096
74Mineral absorption_Homo sapiens_hsa049780.53129660
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.52758869
76Renin-angiotensin system_Homo sapiens_hsa046140.52318470
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.50725508
78Systemic lupus erythematosus_Homo sapiens_hsa053220.49222400
79Acute myeloid leukemia_Homo sapiens_hsa052210.48311853
80Prolactin signaling pathway_Homo sapiens_hsa049170.44397300
81Arachidonic acid metabolism_Homo sapiens_hsa005900.40211486
82HIF-1 signaling pathway_Homo sapiens_hsa040660.39111762
83Type II diabetes mellitus_Homo sapiens_hsa049300.37693865
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.36930854
85Linoleic acid metabolism_Homo sapiens_hsa005910.36338094
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36113248
87Chronic myeloid leukemia_Homo sapiens_hsa052200.36066762
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35427687
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34089859
90Pentose phosphate pathway_Homo sapiens_hsa000300.32459727
91Endocytosis_Homo sapiens_hsa041440.32240427
92Proteoglycans in cancer_Homo sapiens_hsa052050.31377684
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31363748
94Caffeine metabolism_Homo sapiens_hsa002320.30498783
95Renin secretion_Homo sapiens_hsa049240.30397872
96Bladder cancer_Homo sapiens_hsa052190.30372381
97HTLV-I infection_Homo sapiens_hsa051660.30283623
98Epstein-Barr virus infection_Homo sapiens_hsa051690.27992661
99Pancreatic cancer_Homo sapiens_hsa052120.27359634
100Dorso-ventral axis formation_Homo sapiens_hsa043200.27213936
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25350888
102Protein digestion and absorption_Homo sapiens_hsa049740.23850963
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23500969
104Insulin resistance_Homo sapiens_hsa049310.23104401
105PPAR signaling pathway_Homo sapiens_hsa033200.22544276
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21619047
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21278586
108GnRH signaling pathway_Homo sapiens_hsa049120.20100928
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19950438
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.19207754
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.19098509
112Arginine biosynthesis_Homo sapiens_hsa002200.18785399
113Viral carcinogenesis_Homo sapiens_hsa052030.18712877
114Oxidative phosphorylation_Homo sapiens_hsa001900.18043551
115FoxO signaling pathway_Homo sapiens_hsa040680.12932933
116Regulation of autophagy_Homo sapiens_hsa041400.12099836
117VEGF signaling pathway_Homo sapiens_hsa043700.09822468
118Renal cell carcinoma_Homo sapiens_hsa052110.09366299
119Proteasome_Homo sapiens_hsa030500.07066822

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