MMP13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to vitamin D (GO:0071305)6.54031855
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.04197262
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.04197262
4modulation by symbiont of host immune response (GO:0052553)6.04197262
5positive regulation by symbiont of host defense response (GO:0052509)6.04197262
6modulation by symbiont of host defense response (GO:0052031)6.04197262
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.04197262
8cellular response to vitamin (GO:0071295)5.71154820
9regulation of transforming growth factor beta2 production (GO:0032909)5.47039157
10establishment of tissue polarity (GO:0007164)5.25414359
11establishment of planar polarity (GO:0001736)5.25414359
12intestinal epithelial cell development (GO:0060576)5.06644718
13mesodermal cell differentiation (GO:0048333)5.00669451
14positive regulation of chemokine biosynthetic process (GO:0045080)4.92607038
15protein heterotrimerization (GO:0070208)4.90473105
16regulation of gonadotropin secretion (GO:0032276)4.85206539
17positive regulation of osteoblast proliferation (GO:0033690)4.77732620
18collagen fibril organization (GO:0030199)4.74488782
19response to vitamin D (GO:0033280)4.72569282
20tooth mineralization (GO:0034505)4.65231374
21diterpenoid biosynthetic process (GO:0016102)4.59810959
22macrophage activation involved in immune response (GO:0002281)4.29676264
23skin morphogenesis (GO:0043589)4.22729102
24pericardium development (GO:0060039)4.19228451
25negative regulation of biomineral tissue development (GO:0070168)4.14823512
26regulation of interferon-beta biosynthetic process (GO:0045357)4.12221780
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.07976781
28keratinocyte proliferation (GO:0043616)4.07811042
29hypotonic response (GO:0006971)4.05868336
30* collagen catabolic process (GO:0030574)4.04980478
31positive regulation of epidermal cell differentiation (GO:0045606)4.00905459
32response to peptidoglycan (GO:0032494)3.98932966
33* collagen metabolic process (GO:0032963)3.96352710
34dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.95093564
35ganglion development (GO:0061548)3.94905333
36response to gravity (GO:0009629)3.92235588
37negative regulation of keratinocyte proliferation (GO:0010839)3.91767527
38response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.91620832
39response to host immune response (GO:0052572)3.91620832
40* biomineral tissue development (GO:0031214)3.88581335
41negative regulation of bone mineralization (GO:0030502)3.84962911
42keratan sulfate biosynthetic process (GO:0018146)3.82782578
43negative regulation of chondrocyte differentiation (GO:0032331)3.82779130
44basement membrane organization (GO:0071711)3.81433173
45hemidesmosome assembly (GO:0031581)3.79937256
46cell adhesion mediated by integrin (GO:0033627)3.77725643
47endodermal cell differentiation (GO:0035987)3.77374868
48positive regulation of interferon-alpha production (GO:0032727)3.68513548
49* multicellular organismal catabolic process (GO:0044243)3.68129074
50keratan sulfate catabolic process (GO:0042340)3.67382685
51* multicellular organismal macromolecule metabolic process (GO:0044259)3.67130563
52regulation of alkaline phosphatase activity (GO:0010692)3.65034090
53positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.64389555
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.61526330
55response to host (GO:0075136)3.61526330
56response to host defenses (GO:0052200)3.61526330
57wound healing, spreading of cells (GO:0044319)3.60898898
58desmosome organization (GO:0002934)3.60658951
59low-density lipoprotein particle clearance (GO:0034383)3.58594408
60regulation of chemokine biosynthetic process (GO:0045073)3.56859539
61cellular response to interferon-alpha (GO:0035457)3.56339959
62wound healing, spreading of epidermal cells (GO:0035313)3.56208408
63bone resorption (GO:0045453)3.56074288
64regulation of interferon-alpha production (GO:0032647)3.54906857
65renal filtration (GO:0097205)3.54405873
66trivalent inorganic anion homeostasis (GO:0072506)3.53907818
67phosphate ion homeostasis (GO:0055062)3.53907818
68regulation of mononuclear cell migration (GO:0071675)3.52668499
69keratan sulfate metabolic process (GO:0042339)3.52565077
70positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.52036018
71regulation of keratinocyte proliferation (GO:0010837)3.50014652
72surfactant homeostasis (GO:0043129)3.48642861
73muscle cell migration (GO:0014812)3.47849384
74* multicellular organismal metabolic process (GO:0044236)3.44125362
75endocrine hormone secretion (GO:0060986)3.39562933
76axon extension involved in axon guidance (GO:0048846)3.38099854
77neuron projection extension involved in neuron projection guidance (GO:1902284)3.38099854
78detection of molecule of bacterial origin (GO:0032490)3.37932092
79adhesion of symbiont to host cell (GO:0044650)3.37891863
80virion attachment to host cell (GO:0019062)3.37891863
81neutrophil activation involved in immune response (GO:0002283)3.35945078
82regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.35628142
83positive regulation of heat generation (GO:0031652)3.35323296
84dopaminergic neuron differentiation (GO:0071542)3.34016692
85substrate-dependent cell migration (GO:0006929)3.32507816
86Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.27687108
87lipopolysaccharide-mediated signaling pathway (GO:0031663)3.27087718
88response to interferon-alpha (GO:0035455)3.25480622
89regulation of fever generation (GO:0031620)3.25067074
90regulation of membrane protein ectodomain proteolysis (GO:0051043)3.24800245
91regulation of establishment of planar polarity (GO:0090175)3.21095344
92cellular response to nutrient (GO:0031670)3.20995554
93positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.17670493
94* extracellular matrix disassembly (GO:0022617)3.16889319
95* endochondral ossification (GO:0001958)3.16709397
96* replacement ossification (GO:0036075)3.16709397
97microglial cell activation (GO:0001774)3.16425648
98bundle of His cell to Purkinje myocyte communication (GO:0086069)3.16109699
99apoptotic cell clearance (GO:0043277)3.13600285
100embryonic cranial skeleton morphogenesis (GO:0048701)3.12952191
101chemical homeostasis within a tissue (GO:0048875)3.12903449
102terpenoid biosynthetic process (GO:0016114)3.11080279
103regulation of transforming growth factor beta production (GO:0071634)3.10074763
104chondrocyte proliferation (GO:0035988)3.09047411
105negative regulation of macrophage differentiation (GO:0045650)3.08036166
106regulation of bone remodeling (GO:0046850)3.06207577
107mesenchymal-epithelial cell signaling (GO:0060638)3.05528415
108positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.04497145
109regulation of water loss via skin (GO:0033561)3.02818276
110bone trabecula formation (GO:0060346)3.02664323
111negative regulation of interleukin-12 production (GO:0032695)3.02522991
112regulation of odontogenesis (GO:0042481)3.00213525
113regulation of podosome assembly (GO:0071801)2.99464713
114iron ion import (GO:0097286)2.98384011
115positive regulation of transforming growth factor beta production (GO:0071636)2.96938575
116positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.95668270
117cell migration involved in heart development (GO:0060973)2.94152412
118cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.92510891
119regulation of transmission of nerve impulse (GO:0051969)2.92274138
120regulation of macrophage cytokine production (GO:0010935)2.92227353
121positive regulation of chemokine production (GO:0032722)2.91528564
122cartilage condensation (GO:0001502)2.90356800
123cell aggregation (GO:0098743)2.90356800
124regulation of vitamin D biosynthetic process (GO:0060556)2.90124585
125peptidyl-proline hydroxylation (GO:0019511)2.89357380
126regulation of T-helper 1 cell differentiation (GO:0045625)2.89039023
127macrophage activation (GO:0042116)2.88915792
128regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.87216132
129positive regulation of macrophage cytokine production (GO:0060907)2.87027744
130immunoglobulin mediated immune response (GO:0016064)2.84902189
131chronic inflammatory response (GO:0002544)2.84698618
132adhesion of symbiont to host (GO:0044406)2.84515457
133regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.83737041
134hydrogen peroxide biosynthetic process (GO:0050665)2.83372488
135phagocytosis, recognition (GO:0006910)2.82665028
136establishment of skin barrier (GO:0061436)2.80731072
137cellular response to amino acid stimulus (GO:0071230)2.80614284
138positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.80249173
139glomerular filtration (GO:0003094)2.74949099
140smooth muscle tissue development (GO:0048745)2.73982194
141positive regulation of positive chemotaxis (GO:0050927)2.73966402
142regulation of osteoblast proliferation (GO:0033688)2.73220044
143response to phenylpropanoid (GO:0080184)2.73014094
144decidualization (GO:0046697)2.72855537
145positive regulation of interferon-beta production (GO:0032728)2.71989467
146regulation of extracellular matrix disassembly (GO:0010715)2.71798384
147positive regulation of bone remodeling (GO:0046852)2.70852985
148positive regulation of bone resorption (GO:0045780)2.70852985
149regulation of positive chemotaxis (GO:0050926)2.70794715
150hepatocyte differentiation (GO:0070365)2.70546253
151positive regulation of catenin import into nucleus (GO:0035413)2.69434140
152I-kappaB phosphorylation (GO:0007252)2.68788436
153negative regulation of axon extension involved in axon guidance (GO:0048843)2.68336634
154negative regulation of interleukin-17 production (GO:0032700)2.68330391
155* ossification (GO:0001503)2.67984113
156chondrocyte development (GO:0002063)2.67241823
157regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.66516522
158* extracellular matrix organization (GO:0030198)2.64541390
159negative regulation of gluconeogenesis (GO:0045721)2.64288359
160cellular response to ATP (GO:0071318)2.64021202
161* extracellular structure organization (GO:0043062)2.63851718
162regulation of cholesterol storage (GO:0010885)2.63535437
163positive regulation of p38MAPK cascade (GO:1900745)2.63439382
164regulation of dendritic cell antigen processing and presentation (GO:0002604)2.63427379
165regulation of chemokine-mediated signaling pathway (GO:0070099)2.63196349
166complement activation, classical pathway (GO:0006958)2.62924719
167positive regulation of nitric oxide biosynthetic process (GO:0045429)2.61629997
168positive regulation of epidermis development (GO:0045684)2.61408122
169epithelial cell maturation (GO:0002070)2.59785887
170myoblast migration (GO:0051451)2.56904915
171regulation of cardioblast differentiation (GO:0051890)2.56120057
172cellular response to cholesterol (GO:0071397)2.55907883

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.15891072
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.13174539
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.82932115
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.67885950
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.43254821
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.35896495
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.34010794
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.17459381
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06460648
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.99608580
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.99371718
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.94246395
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89382817
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.82301692
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.81571782
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.79824317
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.54216816
18* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.27989073
19* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.26781194
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26696907
21AHR_22903824_ChIP-Seq_MCF-7_Human2.18591050
22* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.16316429
23RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.14119358
24WT1_19549856_ChIP-ChIP_CCG9911_Human2.11703985
25RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08710902
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00857974
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.99468087
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.98890417
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98189845
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98172631
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98012110
32FOXM1_26456572_ChIP-Seq_MCF-7_Human1.95549165
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.95281424
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.93168661
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.93168661
36CJUN_26792858_Chip-Seq_BT549_Human1.92440484
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90415850
38* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84480363
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.81499298
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.72836677
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72561374
42VDR_24787735_ChIP-Seq_THP-1_Human1.71522546
43GBX2_23144817_ChIP-Seq_PC3_Human1.71456574
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69523758
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67901671
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62725143
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.62585627
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62097339
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61048197
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.57299082
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56761653
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54975873
53CLOCK_20551151_ChIP-Seq_293T_Human1.53142460
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49538871
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48265017
56* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45885485
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45321336
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44694384
59SOX2_20726797_ChIP-Seq_SW620_Human1.44340197
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42943294
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39305471
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.39134113
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38559623
64ER_23166858_ChIP-Seq_MCF-7_Human1.37782473
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36636380
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.34878655
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.34281307
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34116459
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33012450
70BRD4_25478319_ChIP-Seq_HGPS_Human1.32063725
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31732844
72* SMAD4_21799915_ChIP-Seq_A2780_Human1.29721992
73PU_27001747_Chip-Seq_BMDM_Mouse1.29679572
74* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29109118
75* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28648572
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27802927
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.27500415
78EP300_21415370_ChIP-Seq_HL-1_Mouse1.25475582
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25417793
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.24258306
81CDX2_22108803_ChIP-Seq_LS180_Human1.23805685
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.21344813
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.19980786
84P53_22387025_ChIP-Seq_ESCs_Mouse1.19582296
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19164127
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18222792
87* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18168348
88* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18168348
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.16840151
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.16679877
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.16255890
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.15160865
93SOX2_18555785_Chip-Seq_ESCs_Mouse1.13537017
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12818441
95P300_18555785_Chip-Seq_ESCs_Mouse1.11474515
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10901757
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10547842
98VDR_24763502_ChIP-Seq_THP-1_Human1.10247082
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09372289
100TP53_18474530_ChIP-ChIP_U2OS_Human1.09177695
101SPI1_23127762_ChIP-Seq_K562_Human1.09137555
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08924649
103* AR_25329375_ChIP-Seq_VCAP_Human1.08828148
104OCT4_18555785_Chip-Seq_ESCs_Mouse1.08235922
105* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08094917
106* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07779240
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07727133
108NMYC_18555785_Chip-Seq_ESCs_Mouse1.05958938
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03462304
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03082630
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.02335762
112ESR1_20079471_ChIP-ChIP_T-47D_Human1.01884593
113SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01558625
114* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01486687
115ZFX_18555785_Chip-Seq_ESCs_Mouse1.01308199
116GATA3_24758297_ChIP-Seq_MCF-7_Human1.01163953
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01128082
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00932421
119CBP_20019798_ChIP-Seq_JUKART_Human1.00580202
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00580202
121SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99883160
122ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99308506
123PU1_27457419_Chip-Seq_LIVER_Mouse0.98439972
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98174219
125CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97948800
126SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96751643
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95556204
128CTCF_18555785_Chip-Seq_ESCs_Mouse0.95379705
129KLF4_18555785_Chip-Seq_ESCs_Mouse0.95152626
130ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94252469
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93202306
132P300_19829295_ChIP-Seq_ESCs_Human0.92404846
133VDR_22108803_ChIP-Seq_LS180_Human0.91660053
134RUNX_20019798_ChIP-Seq_JUKART_Human0.90977949
135TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90715650
136EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90704509
137* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90084604
138UBF1/2_26484160_Chip-Seq_HMECs_Human0.89208160
139SPI1_23547873_ChIP-Seq_NB4_Human0.88485666
140CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88455972
141* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88102618
142RXR_22108803_ChIP-Seq_LS180_Human0.85958430
143KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84665783
144TP63_23658742_ChIP-Seq_EP156T_Human0.82060655
145ATF3_27146783_Chip-Seq_COLON_Human0.80661566
146GATA1_22025678_ChIP-Seq_K562_Human0.80079390
147MAF_26560356_Chip-Seq_TH1_Human0.79234854
148ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77555047
149PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76147145
150PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75546957
151ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75466442
152TP53_16413492_ChIP-PET_HCT116_Human0.75089173
153MYB_26560356_Chip-Seq_TH2_Human0.74825987
154KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.74057009
155SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73634988
156WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.73345909
157ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.72373599
158ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.72209300
159SOX9_24532713_ChIP-Seq_HFSC_Mouse0.71605799
160RUNX1_22412390_ChIP-Seq_EML_Mouse0.70062481
161* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69667478

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.81049831
2MP0001542_abnormal_bone_strength4.99483255
3MP0005275_abnormal_skin_tensile4.23937766
4MP0005503_abnormal_tendon_morphology4.20308044
5MP0004185_abnormal_adipocyte_glucose3.67553411
6MP0002998_abnormal_bone_remodeling3.25545966
7MP0003283_abnormal_digestive_organ2.92484697
8MP0003279_aneurysm2.91610725
9MP0000566_synostosis2.72794445
10MP0003705_abnormal_hypodermis_morpholog2.62725601
11* MP0001533_abnormal_skeleton_physiology2.60136541
12MP0002896_abnormal_bone_mineralization2.48887255
13MP0005257_abnormal_intraocular_pressure2.47678749
14MP0003303_peritoneal_inflammation2.28950306
15MP0003436_decreased_susceptibility_to2.22272887
16MP0006054_spinal_hemorrhage2.12112743
17MP0002933_joint_inflammation2.10175798
18MP0009785_altered_susceptibility_to1.98852910
19MP0001958_emphysema1.95003869
20MP0003724_increased_susceptibility_to1.92332107
21MP0000762_abnormal_tongue_morphology1.91454085
22* MP0005390_skeleton_phenotype1.91162341
23MP0006082_CNS_inflammation1.89715985
24MP0002419_abnormal_innate_immunity1.88342307
25MP0000579_abnormal_nail_morphology1.85261912
26MP0002148_abnormal_hypersensitivity_rea1.84252072
27MP0010030_abnormal_orbit_morphology1.82725822
28MP0009278_abnormal_bone_marrow1.82358934
29MP0005187_abnormal_penis_morphology1.81466787
30MP0003950_abnormal_plasma_membrane1.81248548
31* MP0005023_abnormal_wound_healing1.72294472
32MP0009053_abnormal_anal_canal1.68759621
33MP0004510_myositis1.68558044
34MP0003195_calcinosis1.68307353
35* MP0003795_abnormal_bone_structure1.68035140
36MP0002295_abnormal_pulmonary_circulatio1.66515119
37MP0001835_abnormal_antigen_presentation1.64548997
38MP0000604_amyloidosis1.61831680
39MP0000343_altered_response_to1.60635823
40* MP0002115_abnormal_skeleton_extremities1.58446433
41MP0005000_abnormal_immune_tolerance1.56354264
42MP0005058_abnormal_lysosome_morphology1.53122708
43MP0004272_abnormal_basement_membrane1.52810945
44MP0003448_altered_tumor_morphology1.52655250
45MP0003566_abnormal_cell_adhesion1.49908920
46MP0003300_gastrointestinal_ulcer1.47994708
47MP0005508_abnormal_skeleton_morphology1.46658705
48MP0009384_cardiac_valve_regurgitation1.43749110
49MP0000383_abnormal_hair_follicle1.40727040
50MP0005025_abnormal_response_to1.38913677
51MP0004947_skin_inflammation1.38625147
52MP0001216_abnormal_epidermal_layer1.38368135
53MP0002060_abnormal_skin_morphology1.36931111
54MP0004858_abnormal_nervous_system1.36636597
55MP0005408_hypopigmentation1.36338190
56MP0002098_abnormal_vibrissa_morphology1.35169335
57MP0003075_altered_response_to1.34967141
58MP0000569_abnormal_digit_pigmentation1.34012725
59MP0003136_yellow_coat_color1.33855340
60MP0003091_abnormal_cell_migration1.32352342
61MP0005409_darkened_coat_color1.31776656
62MP0005387_immune_system_phenotype1.30462295
63MP0001790_abnormal_immune_system1.30462295
64MP0005666_abnormal_adipose_tissue1.30126931
65MP0010352_gastrointestinal_tract_polyps1.29937375
66* MP0002113_abnormal_skeleton_development1.25080091
67MP0002452_abnormal_antigen_presenting1.21720732
68MP0004264_abnormal_extraembryonic_tissu1.19546389
69MP0010771_integument_phenotype1.18662755
70MP0001243_abnormal_dermal_layer1.18570350
71MP0001299_abnormal_eye_distance/1.17019655
72MP0000685_abnormal_immune_system1.16050607
73MP0010678_abnormal_skin_adnexa1.15562919
74MP0009764_decreased_sensitivity_to1.14719512
75* MP0005164_abnormal_response_to1.14042962
76MP0000627_abnormal_mammary_gland1.13096048
77MP0000432_abnormal_head_morphology1.12056171
78MP0000613_abnormal_salivary_gland1.11858940
79MP0005248_abnormal_Harderian_gland1.11228681
80* MP0000163_abnormal_cartilage_morphology1.10747876
81MP0003172_abnormal_lysosome_physiology1.10297121
82MP0002796_impaired_skin_barrier1.09370851
83MP0001879_abnormal_lymphatic_vessel1.09007032
84MP0002108_abnormal_muscle_morphology1.08750475
85MP0005166_decreased_susceptibility_to1.06765210
86MP0008004_abnormal_stomach_pH1.02396443
87MP0009250_abnormal_appendicular_skeleto1.01080681
88MP0000377_abnormal_hair_follicle1.00376795
89MP0000427_abnormal_hair_cycle0.99116808
90MP0004134_abnormal_chest_morphology0.97439814
91MP0005076_abnormal_cell_differentiation0.96957261
92MP0002282_abnormal_trachea_morphology0.93325161
93MP0003937_abnormal_limbs/digits/tail_de0.92637541
94MP0002723_abnormal_immune_serum0.92121732
95MP0005397_hematopoietic_system_phenotyp0.91401524
96MP0001545_abnormal_hematopoietic_system0.91401524
97MP0003935_abnormal_craniofacial_develop0.90913641
98MP0003045_fibrosis0.90051477
99MP0005464_abnormal_platelet_physiology0.89761308
100MP0000467_abnormal_esophagus_morphology0.89539378
101MP0003755_abnormal_palate_morphology0.89463742
102MP0005375_adipose_tissue_phenotype0.89069443
103MP0009780_abnormal_chondrocyte_physiolo0.88379858
104MP0010307_abnormal_tumor_latency0.88274207
105MP0001819_abnormal_immune_cell0.84049637
106MP0008469_abnormal_protein_level0.83895911
107MP0001845_abnormal_inflammatory_respons0.83193771
108MP0005623_abnormal_meninges_morphology0.82906883
109MP0010368_abnormal_lymphatic_system0.82875560
110MP0002420_abnormal_adaptive_immunity0.81932793
111MP0001853_heart_inflammation0.81774122
112MP0000858_altered_metastatic_potential0.81608214
113MP0002405_respiratory_system_inflammati0.81603365
114MP0001191_abnormal_skin_condition0.81270574
115MP0009115_abnormal_fat_cell0.81133197
116MP0001800_abnormal_humoral_immune0.80811841
117MP0002233_abnormal_nose_morphology0.79244494
118MP0003646_muscle_fatigue0.77979170
119MP0002168_other_aberrant_phenotype0.77866925
120MP0002332_abnormal_exercise_endurance0.77785749
121MP0004885_abnormal_endolymph0.76719255
122MP0000767_abnormal_smooth_muscle0.76241915
123MP0000372_irregular_coat_pigmentation0.72863168
124MP0002254_reproductive_system_inflammat0.71856952
125MP0005197_abnormal_uvea_morphology0.71427812
126MP0002116_abnormal_craniofacial_bone0.70965848
127MP0005171_absent_coat_pigmentation0.70752255
128MP0005671_abnormal_response_to0.70446102
129MP0003453_abnormal_keratinocyte_physiol0.69571605
130MP0000537_abnormal_urethra_morphology0.69097926
131MP0001346_abnormal_lacrimal_gland0.68965414
132MP0010386_abnormal_urinary_bladder0.68933784
133MP0003191_abnormal_cellular_cholesterol0.68250932
134MP0001915_intracranial_hemorrhage0.67608917
135MP0004883_abnormal_blood_vessel0.67419356
136MP0010155_abnormal_intestine_physiology0.67062384
137MP0003936_abnormal_reproductive_system0.66896516
138MP0000733_abnormal_muscle_development0.66295660
139* MP0002109_abnormal_limb_morphology0.66126017
140MP0002877_abnormal_melanocyte_morpholog0.65174188
141MP0004808_abnormal_hematopoietic_stem0.63023557
142MP0002089_abnormal_postnatal_growth/wei0.62951186
143MP0000647_abnormal_sebaceous_gland0.60212380
144MP0002006_tumorigenesis0.59172031
145MP0003315_abnormal_perineum_morphology0.59051294
146MP0005165_increased_susceptibility_to0.57948665
147MP0009840_abnormal_foam_cell0.57710662
148MP0004019_abnormal_vitamin_homeostasis0.57511473
149MP0005193_abnormal_anterior_eye0.57177826

Predicted human phenotypes

RankGene SetZ-score
1Metaphyseal dysplasia (HP:0100255)7.18982692
2Protrusio acetabuli (HP:0003179)7.06792125
3Premature rupture of membranes (HP:0001788)6.55510639
4Peritonitis (HP:0002586)5.15933932
5Vertebral compression fractures (HP:0002953)4.32165779
6Atrophic scars (HP:0001075)4.22813817
7Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.08491131
8Alopecia of scalp (HP:0002293)4.05053729
9Ridged nail (HP:0001807)4.05008767
10Biconcave vertebral bodies (HP:0004586)3.93850168
11Cervical subluxation (HP:0003308)3.92017290
12Soft skin (HP:0000977)3.82897787
13Wormian bones (HP:0002645)3.75060032
14Aortic dissection (HP:0002647)3.66282395
15Eczematoid dermatitis (HP:0000976)3.66061342
16Abnormality of dentin (HP:0010299)3.63600776
17Neonatal short-limb short stature (HP:0008921)3.62275179
18* Metaphyseal cupping (HP:0003021)3.58382294
19Genu recurvatum (HP:0002816)3.56166109
20Delayed closure of the anterior fontanelle (HP:0001476)3.48387996
21Epiphyseal dysplasia (HP:0002656)3.28699576
22Blue sclerae (HP:0000592)3.26030918
23* Irregular vertebral endplates (HP:0003301)3.23960957
24Hypophosphatemic rickets (HP:0004912)3.19477420
25Ankle contracture (HP:0006466)3.17139479
26Enlarged epiphyses (HP:0010580)3.11889650
27Hypoplastic labia majora (HP:0000059)3.00748500
28Hypoplastic ischia (HP:0003175)2.98871359
29* Osteoarthritis (HP:0002758)2.98209800
30Broad metatarsal (HP:0001783)2.98073364
31Follicular hyperkeratosis (HP:0007502)2.95632052
32Shallow orbits (HP:0000586)2.92120491
33Recurrent abscess formation (HP:0002722)2.91461720
34Onycholysis (HP:0001806)2.86975836
35Osteolytic defects of the phalanges of the hand (HP:0009771)2.84550970
36Osteolytic defects of the hand bones (HP:0009699)2.84550970
37Overgrowth (HP:0001548)2.83813392
38* Genu varum (HP:0002970)2.81711118
39Bladder diverticulum (HP:0000015)2.81231964
40Abnormality of the labia majora (HP:0012881)2.78634365
41Increased cerebral lipofuscin (HP:0011813)2.78274024
42Abnormality of the ischium (HP:0003174)2.76222620
43Delayed cranial suture closure (HP:0000270)2.75607001
44Fragile skin (HP:0001030)2.74509063
45Broad ribs (HP:0000885)2.72841313
46Recurrent bacterial skin infections (HP:0005406)2.71638014
47Vascular tortuosity (HP:0004948)2.71629130
48Mild short stature (HP:0003502)2.71029598
49Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.70880647
50Absent frontal sinuses (HP:0002688)2.70780319
51Thick nail (HP:0001805)2.70398718
52Popliteal pterygium (HP:0009756)2.70111532
53Abnormality of incisor morphology (HP:0011063)2.67451304
54Autoimmune thrombocytopenia (HP:0001973)2.62025365
55* Platyspondyly (HP:0000926)2.60927899
56Cranial hyperostosis (HP:0004437)2.58507078
57Dilatation of the ascending aorta (HP:0005111)2.55311901
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.55151447
59Breast hypoplasia (HP:0003187)2.52286075
60Spinal cord compression (HP:0002176)2.51141983
61* Femoral bowing (HP:0002980)2.50818802
62Recurrent gram-negative bacterial infections (HP:0005420)2.47259690
63Persistence of primary teeth (HP:0006335)2.47180834
64Nonimmune hydrops fetalis (HP:0001790)2.44992734
65Abnormality of calcium-phosphate metabolism (HP:0100530)2.44279363
66Hyperextensible skin (HP:0000974)2.43418447
67Abnormality of the acetabulum (HP:0003170)2.42544193
68Abnormality of macrophages (HP:0004311)2.42212576
69Mitral valve prolapse (HP:0001634)2.40570430
70Premature loss of primary teeth (HP:0006323)2.40152371
71Abnormal delivery (HP:0001787)2.36889273
72Abnormality of the peritoneum (HP:0002585)2.34285662
73Right ventricular cardiomyopathy (HP:0011663)2.34281951
74Spondylolisthesis (HP:0003302)2.32331999
75Milia (HP:0001056)2.31125336
76Decreased skull ossification (HP:0004331)2.30871522
77Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.26438739
78Abnormality of skull ossification (HP:0002703)2.25037333
79Abnormality of the distal phalanges of the toes (HP:0010182)2.24856571
80Ankyloglossia (HP:0010296)2.24366511
81* Cupped ribs (HP:0000887)2.23584109
82Neurofibrillary tangles (HP:0002185)2.23390835
83Short middle phalanx of the 5th finger (HP:0004220)2.23031511
84Cerebral aneurysm (HP:0004944)2.22935886
85Papilledema (HP:0001085)2.19460238
86Bell-shaped thorax (HP:0001591)2.15639858
87Beaking of vertebral bodies (HP:0004568)2.15552611
88Stomatitis (HP:0010280)2.14554752
89Arthropathy (HP:0003040)2.14418544
90Tetraparesis (HP:0002273)2.13688836
91Myositis (HP:0100614)2.13450029
92* Tibial bowing (HP:0002982)2.12677003
93Keratoconus (HP:0000563)2.12581605
94Increased corneal curvature (HP:0100692)2.12581605
95Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.11946237
96* Coxa vara (HP:0002812)2.11728959
97Tubulointerstitial fibrosis (HP:0005576)2.11702456
98Slender build (HP:0001533)2.11424904
99Abnormality of oral frenula (HP:0000190)2.11098581
100Abnormality of the phalanges of the 2nd finger (HP:0009541)2.10006476
101Elevated erythrocyte sedimentation rate (HP:0003565)2.09621181
102Abnormality of the frontal sinuses (HP:0002687)2.08925352
103Breech presentation (HP:0001623)2.08276977
104Abnormality of proline metabolism (HP:0010907)2.07815255
105Hydroxyprolinuria (HP:0003080)2.07815255
106Increased density of long bones (HP:0006392)2.07774133
107Pathologic fracture (HP:0002756)2.07751254
108Orchitis (HP:0100796)2.07537086
109Infantile muscular hypotonia (HP:0008947)2.05605627
110Systemic lupus erythematosus (HP:0002725)2.04605356
111Short middle phalanx of finger (HP:0005819)2.03305160
112Mediastinal lymphadenopathy (HP:0100721)2.02623507
113Aortic aneurysm (HP:0004942)2.02456185
114Ovoid vertebral bodies (HP:0003300)2.01623774
115Ectopia lentis (HP:0001083)2.01395780
116Myocardial infarction (HP:0001658)2.01217664
117Hypotrichosis (HP:0001006)1.99740281
118Pterygium (HP:0001059)1.99234046
119Increased number of teeth (HP:0011069)1.97440754
120Vertebral clefting (HP:0008428)1.95496449
121Joint laxity (HP:0001388)1.95378645
122Interstitial pulmonary disease (HP:0006530)1.95176781
123Facial diplegia (HP:0001349)1.94628485
124Delayed epiphyseal ossification (HP:0002663)1.92843358
125Type 1 muscle fiber predominance (HP:0003803)1.91130108
126Sparse eyelashes (HP:0000653)1.89857010
127Protuberant abdomen (HP:0001538)1.89531506
128Craniofacial hyperostosis (HP:0004493)1.89465315
129Narrow palate (HP:0000189)1.88369967
130Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.87978488
131Gingivitis (HP:0000230)1.87228894
132Hypoplasia of the odontoid process (HP:0003311)1.86595255
133Syringomyelia (HP:0003396)1.86402109
134Spinal cord lesions (HP:0100561)1.86402109
135Arterial tortuosity (HP:0005116)1.86263247
136* Ulnar bowing (HP:0003031)1.85173377
137Osteomalacia (HP:0002749)1.84095754
138* Abnormality of the vertebral endplates (HP:0005106)1.83938179
139Blepharitis (HP:0000498)1.83718742
140Abnormality of primary teeth (HP:0006481)1.81793547
141Elbow flexion contracture (HP:0002987)1.81664910
142Aplasia of the musculature (HP:0100854)1.81479633
143Oligodontia (HP:0000677)1.81369790
144Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.79755437
145Selective tooth agenesis (HP:0001592)1.79489688
146Conical tooth (HP:0000698)1.79364061
147Fibular hypoplasia (HP:0003038)1.78846439
148Bone pain (HP:0002653)1.73120679
149Hypoplastic nipples (HP:0002557)1.72154017
150Abnormality of the middle phalanges of the hand (HP:0009833)1.71309388
151Hypoplastic scapulae (HP:0000882)1.68745181
152Aplasia/Hypoplasia of the scapulae (HP:0006713)1.68745181
153Nail dystrophy (HP:0008404)1.68320324
154Plantar hyperkeratosis (HP:0007556)1.68190571
155Labial hypoplasia (HP:0000066)1.66785107
156Tubular atrophy (HP:0000092)1.62712404
157Cardiovascular calcification (HP:0011915)1.61631737
158Prominent nose (HP:0000448)1.61615961
159Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.60830416
160Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.59315432

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR27.18038326
2EPHA24.30250016
3TRIM282.97967332
4PBK2.97750061
5ERN12.94723491
6PNCK2.85582654
7TBK12.85255083
8EPHA32.81175850
9SIK12.72289815
10BLK2.58093822
11RIPK42.57118327
12CDK82.51793770
13TYK22.48058154
14PDGFRA2.36204800
15MAP3K122.32042804
16JAK12.13850140
17AKT32.05919521
18EIF2AK11.98534751
19KIT1.94001428
20LMTK21.93264237
21MAP3K141.92637872
22PIM21.89618604
23PKN21.86834172
24PTK21.81236581
25JAK31.78938966
26BMX1.73042341
27TRIB31.71517171
28IKBKB1.59600425
29DMPK1.55414376
30EPHB11.47746761
31TGFBR11.45611905
32TTN1.45568662
33IKBKE1.44034232
34STK38L1.42041351
35RIPK11.40090343
36EIF2AK31.35796377
37MST1R1.35719804
38MAP3K91.35191421
39NME21.31432577
40NEK91.29817724
41TRPM71.27525121
42IRAK41.26196943
43FGFR31.24596223
44CSF1R1.22582539
45PDGFRB1.18724821
46FGFR41.15379372
47FGR1.14754478
48ERBB41.13540666
49ABL21.08674130
50PTK61.03572732
51FLT31.00944057
52RPS6KA41.00331242
53MET1.00208208
54CSK0.99586782
55BMPR20.98675362
56CHUK0.98674182
57MELK0.98600433
58MAP4K10.98102797
59STK30.95141165
60LRRK20.94707677
61TXK0.94350058
62ZAP700.93268673
63MYLK0.93241712
64NUAK10.91840955
65TGFBR20.90376697
66CDK60.88323101
67MATK0.87758497
68IRAK30.87059913
69JAK20.86705768
70HCK0.85967366
71BCR0.84043956
72PLK20.83272633
73LIMK10.82581577
74LATS10.78496928
75WNK40.78292153
76MAP3K30.78126912
77MAP3K130.75312198
78LYN0.74944499
79KSR20.74135974
80FGFR10.73163617
81SCYL20.72497862
82STK380.71373169
83TESK10.68850757
84EGFR0.68736733
85BRSK10.64452118
86LCK0.64182948
87NTRK10.63993853
88EIF2AK20.63540332
89EPHA40.62726912
90FRK0.62142769
91PAK40.61524509
92SIK30.61291944
93ABL10.59734681
94CASK0.58723679
95PRKG20.57323469
96STK390.55089078
97MARK30.54541965
98STK240.54395471
99CDC42BPA0.53997578
100TAOK30.53536128
101MAP3K50.52276861
102FER0.51258442
103BRSK20.50971829
104SYK0.50413166
105INSR0.49620474
106MAP3K100.49542785
107SGK30.49100027
108ADRBK10.48901211
109KSR10.48719828
110GSK3A0.48232541
111PRKCH0.47994913
112EPHB20.47804188
113MST40.46826834
114RET0.46357794
115ICK0.45983828
116INSRR0.45736691
117STK100.44034473
118FYN0.43917706
119IGF1R0.43170934
120PRKCE0.43014165
121DAPK30.42325084
122ALK0.41230924
123PRKCD0.41134152
124PRKD20.40744684
125ADRBK20.40285530
126SRC0.38742773
127MOS0.38246140
128PTK2B0.37548097
129FGFR20.37370652
130ERBB30.36796735
131SIK20.36770829
132WEE10.35084334
133MAP3K70.34669923
134DYRK1B0.33142893
135SGK20.32779466
136MAP3K20.32609277
137PIK3CA0.32305196
138LATS20.31977414
139FES0.31884373
140PAK20.31483274
141IRAK10.31378199
142CDK90.31122158
143MAP2K70.31040885
144WNK10.30657548
145MAPKAPK50.29265566
146MAPKAPK30.27564420
147ROCK10.25161741
148MTOR0.23299318
149NLK0.23241351
150MUSK0.23218536
151SGK2230.20971995
152SGK4940.20971995

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051443.35785218
2ECM-receptor interaction_Homo sapiens_hsa045123.15026510
3Leishmaniasis_Homo sapiens_hsa051403.00944561
4Rheumatoid arthritis_Homo sapiens_hsa053232.60721474
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.51501877
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.34450627
7TNF signaling pathway_Homo sapiens_hsa046682.31237353
8Staphylococcus aureus infection_Homo sapiens_hsa051502.22309908
9Legionellosis_Homo sapiens_hsa051342.20208402
10Osteoclast differentiation_Homo sapiens_hsa043802.16466530
11Phagosome_Homo sapiens_hsa041452.14933370
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.04818284
13Tuberculosis_Homo sapiens_hsa051522.01533665
14Pertussis_Homo sapiens_hsa051331.99931021
15Graft-versus-host disease_Homo sapiens_hsa053321.99748230
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.97990244
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.95374692
18Lysosome_Homo sapiens_hsa041421.90968312
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.87788028
20Amoebiasis_Homo sapiens_hsa051461.81681471
21Focal adhesion_Homo sapiens_hsa045101.72090309
22Protein digestion and absorption_Homo sapiens_hsa049741.69386090
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60926959
24Salmonella infection_Homo sapiens_hsa051321.53520383
25Toxoplasmosis_Homo sapiens_hsa051451.51451043
26Circadian rhythm_Homo sapiens_hsa047101.50150009
27Measles_Homo sapiens_hsa051621.47706663
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40816679
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39286809
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38383394
31Influenza A_Homo sapiens_hsa051641.36610454
32Allograft rejection_Homo sapiens_hsa053301.32078387
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26071815
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25548433
35Asthma_Homo sapiens_hsa053101.25150037
36Proteoglycans in cancer_Homo sapiens_hsa052051.24913317
37Protein export_Homo sapiens_hsa030601.23897570
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23474420
39African trypanosomiasis_Homo sapiens_hsa051431.23299352
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.20298649
41Basal cell carcinoma_Homo sapiens_hsa052171.17885412
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15615968
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12119932
44Hippo signaling pathway_Homo sapiens_hsa043901.10880425
45Hepatitis B_Homo sapiens_hsa051611.10357161
46N-Glycan biosynthesis_Homo sapiens_hsa005101.10302367
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06981514
48Shigellosis_Homo sapiens_hsa051311.06909680
49Type I diabetes mellitus_Homo sapiens_hsa049401.06860764
50Chemokine signaling pathway_Homo sapiens_hsa040621.05844373
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05713831
52Hematopoietic cell lineage_Homo sapiens_hsa046401.05376107
53Apoptosis_Homo sapiens_hsa042101.01211371
54Pathways in cancer_Homo sapiens_hsa052000.98936218
55Hedgehog signaling pathway_Homo sapiens_hsa043400.98133099
56PI3K-Akt signaling pathway_Homo sapiens_hsa041510.97648182
57Axon guidance_Homo sapiens_hsa043600.96669192
58Chronic myeloid leukemia_Homo sapiens_hsa052200.96144406
59B cell receptor signaling pathway_Homo sapiens_hsa046620.95968073
60Hepatitis C_Homo sapiens_hsa051600.92766259
61HIF-1 signaling pathway_Homo sapiens_hsa040660.92191656
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89824140
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.89620190
64MicroRNAs in cancer_Homo sapiens_hsa052060.87378290
65Dorso-ventral axis formation_Homo sapiens_hsa043200.86238463
66Autoimmune thyroid disease_Homo sapiens_hsa053200.85642320
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.83902350
68Herpes simplex infection_Homo sapiens_hsa051680.83609602
69Phototransduction_Homo sapiens_hsa047440.83587585
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82889168
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.81961559
72Linoleic acid metabolism_Homo sapiens_hsa005910.81758062
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81294384
74Mineral absorption_Homo sapiens_hsa049780.80873174
75Platelet activation_Homo sapiens_hsa046110.80277122
76Small cell lung cancer_Homo sapiens_hsa052220.79987389
77Other glycan degradation_Homo sapiens_hsa005110.79888190
78Antigen processing and presentation_Homo sapiens_hsa046120.77519926
79Folate biosynthesis_Homo sapiens_hsa007900.76309158
80Pancreatic cancer_Homo sapiens_hsa052120.75112419
81Bladder cancer_Homo sapiens_hsa052190.74698302
82Melanoma_Homo sapiens_hsa052180.74220871
83Ether lipid metabolism_Homo sapiens_hsa005650.73733890
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.72385344
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72333906
86Type II diabetes mellitus_Homo sapiens_hsa049300.72226984
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69869382
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68821306
89Wnt signaling pathway_Homo sapiens_hsa043100.67977601
90Prion diseases_Homo sapiens_hsa050200.67061084
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66613275
92Viral myocarditis_Homo sapiens_hsa054160.63982534
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63391485
94Complement and coagulation cascades_Homo sapiens_hsa046100.63345105
95TGF-beta signaling pathway_Homo sapiens_hsa043500.63234147
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62906878
97mTOR signaling pathway_Homo sapiens_hsa041500.61305149
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61304865
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.60788965
100Caffeine metabolism_Homo sapiens_hsa002320.60424031
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.59608583
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59510606
103Insulin resistance_Homo sapiens_hsa049310.59125621
104Adherens junction_Homo sapiens_hsa045200.58996543
105Glioma_Homo sapiens_hsa052140.58884432
106Prolactin signaling pathway_Homo sapiens_hsa049170.58794422
107Prostate cancer_Homo sapiens_hsa052150.57110560
108Vibrio cholerae infection_Homo sapiens_hsa051100.56962157
109Arachidonic acid metabolism_Homo sapiens_hsa005900.54337499
110Starch and sucrose metabolism_Homo sapiens_hsa005000.53723912
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51061402
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.50702686
113VEGF signaling pathway_Homo sapiens_hsa043700.49947168
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48949923
115Renal cell carcinoma_Homo sapiens_hsa052110.48105091
116Acute myeloid leukemia_Homo sapiens_hsa052210.47892514
117Notch signaling pathway_Homo sapiens_hsa043300.47093382
118Collecting duct acid secretion_Homo sapiens_hsa049660.46131377
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44933915
120Thyroid cancer_Homo sapiens_hsa052160.44526552
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43355926
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.41949614
123Renin-angiotensin system_Homo sapiens_hsa046140.41721985
124Dilated cardiomyopathy_Homo sapiens_hsa054140.41436574
125Salivary secretion_Homo sapiens_hsa049700.40408013
126Thyroid hormone synthesis_Homo sapiens_hsa049180.40067054
127Chemical carcinogenesis_Homo sapiens_hsa052040.39548190
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39156884
129Sphingolipid metabolism_Homo sapiens_hsa006000.36869855
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36761647
131Rap1 signaling pathway_Homo sapiens_hsa040150.33594567
132HTLV-I infection_Homo sapiens_hsa051660.33131499
133Endocytosis_Homo sapiens_hsa041440.32660325

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »