MMP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)6.52095719
2collagen fibril organization (GO:0030199)6.30576295
3bone trabecula formation (GO:0060346)5.28720686
4skin morphogenesis (GO:0043589)5.03417860
5* endodermal cell differentiation (GO:0035987)4.88245589
6protein localization to endosome (GO:0036010)4.71539970
7neuron projection extension involved in neuron projection guidance (GO:1902284)4.69151017
8axon extension involved in axon guidance (GO:0048846)4.69151017
9* collagen metabolic process (GO:0032963)4.61326713
10* collagen catabolic process (GO:0030574)4.55260536
11cell adhesion mediated by integrin (GO:0033627)4.55185137
12basement membrane organization (GO:0071711)4.41610976
13sequestering of extracellular ligand from receptor (GO:0035581)4.35808424
14* multicellular organismal macromolecule metabolic process (GO:0044259)4.30034952
15positive regulation of endothelial cell apoptotic process (GO:2000353)4.29532446
16regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.26604678
17negative regulation of fatty acid transport (GO:2000192)4.23586875
18* multicellular organismal catabolic process (GO:0044243)4.16739064
19barbed-end actin filament capping (GO:0051016)4.15751105
20* multicellular organismal metabolic process (GO:0044236)4.04938517
21wound healing, spreading of epidermal cells (GO:0035313)4.01965775
22apoptotic cell clearance (GO:0043277)4.00488716
23* extracellular matrix disassembly (GO:0022617)4.00330049
24* chondrocyte proliferation (GO:0035988)3.90465278
25dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.90427353
26mesenchymal-epithelial cell signaling (GO:0060638)3.75703283
27positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.61684417
28planar cell polarity pathway involved in neural tube closure (GO:0090179)3.52567143
29metanephric mesenchyme development (GO:0072075)3.52195869
30cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.51074716
31cellular response to vitamin (GO:0071295)3.50754566
32regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.49542017
33outer ear morphogenesis (GO:0042473)3.47983288
34G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.41262837
35regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.38254065
36negative regulation of chondrocyte differentiation (GO:0032331)3.36759855
37cellular response to interferon-alpha (GO:0035457)3.35094225
38Golgi transport vesicle coating (GO:0048200)3.33785127
39COPI coating of Golgi vesicle (GO:0048205)3.33785127
40kidney mesenchyme development (GO:0072074)3.30393121
41regulation of early endosome to late endosome transport (GO:2000641)3.28456791
42vascular endothelial growth factor signaling pathway (GO:0038084)3.26921680
43regulation of mononuclear cell migration (GO:0071675)3.25564271
44positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.25435300
45positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.24958101
46vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.24659136
47regulation of vitamin D biosynthetic process (GO:0060556)3.23928676
48dermatan sulfate biosynthetic process (GO:0030208)3.22694638
49hyaluronan catabolic process (GO:0030214)3.21872785
50regulation of membrane protein ectodomain proteolysis (GO:0051043)3.20332584
51wound healing, spreading of cells (GO:0044319)3.20311396
52decidualization (GO:0046697)3.17990928
53positive regulation of epithelial to mesenchymal transition (GO:0010718)3.17525912
54glomerular basement membrane development (GO:0032836)3.13114745
55cellular response to vitamin D (GO:0071305)3.11078374
56extracellular fibril organization (GO:0043206)3.09470813
57hippo signaling (GO:0035329)3.07069773
58epithelial cell-cell adhesion (GO:0090136)3.05723951
59negative regulation of smooth muscle cell migration (GO:0014912)3.05430840
60endothelial cell morphogenesis (GO:0001886)3.02620607
61maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.02597987
62extracellular matrix assembly (GO:0085029)3.01667712
63pinocytosis (GO:0006907)2.98678135
64protein retention in ER lumen (GO:0006621)2.98244941
65* extracellular matrix organization (GO:0030198)2.98080922
66hypotonic response (GO:0006971)2.97118307
67virion attachment to host cell (GO:0019062)2.97097079
68adhesion of symbiont to host cell (GO:0044650)2.97097079
69* extracellular structure organization (GO:0043062)2.96864230
70fibril organization (GO:0097435)2.96422509
71peptidyl-proline hydroxylation (GO:0019511)2.94684520
72middle ear morphogenesis (GO:0042474)2.94439841
73retina vasculature morphogenesis in camera-type eye (GO:0061299)2.94242426
74plasma membrane repair (GO:0001778)2.93928937
75dermatan sulfate metabolic process (GO:0030205)2.93275120
76substrate adhesion-dependent cell spreading (GO:0034446)2.92815929
77regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.92338673
78cellular response to amino acid stimulus (GO:0071230)2.92209650
79positive regulation of extracellular matrix organization (GO:1903055)2.91729818
80endothelial cell chemotaxis (GO:0035767)2.88555667
81venous blood vessel morphogenesis (GO:0048845)2.87609094
82heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.85710406
83substrate-dependent cell migration (GO:0006929)2.83785631
84polarized epithelial cell differentiation (GO:0030859)2.82905868
85type B pancreatic cell proliferation (GO:0044342)2.82475055
86cell proliferation involved in metanephros development (GO:0072203)2.81863323
87renal filtration (GO:0097205)2.80008849
88keratan sulfate catabolic process (GO:0042340)2.78966988
89regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.78486757
90negative regulation of cartilage development (GO:0061037)2.78230409
91cell-substrate junction assembly (GO:0007044)2.75731338
92endocytic recycling (GO:0032456)2.74798010
93positive regulation of receptor recycling (GO:0001921)2.74437530
94adhesion of symbiont to host (GO:0044406)2.73289483
95hemidesmosome assembly (GO:0031581)2.73021127
96mesodermal cell differentiation (GO:0048333)2.72362724
97glomerular filtration (GO:0003094)2.71702400
98cellular response to thyroid hormone stimulus (GO:0097067)2.71424528
99cell migration involved in heart development (GO:0060973)2.70557997
100endocardial cushion development (GO:0003197)2.70554227
101positive regulation of astrocyte differentiation (GO:0048711)2.70228159
102protein localization to cell surface (GO:0034394)2.69074548
103stress fiber assembly (GO:0043149)2.68995695
104anatomical structure regression (GO:0060033)2.68649603
105cell migration involved in sprouting angiogenesis (GO:0002042)2.68550137
106embryonic skeletal joint morphogenesis (GO:0060272)2.68151724
107embryo implantation (GO:0007566)2.67692796
108chondrocyte development (GO:0002063)2.67443116
109branching involved in salivary gland morphogenesis (GO:0060445)2.66784177
110regulation of extracellular matrix disassembly (GO:0010715)2.66766995
111blood vessel maturation (GO:0001955)2.66450226
112positive regulation of osteoblast proliferation (GO:0033690)2.66285037
113response to fluid shear stress (GO:0034405)2.63921777
114chondroitin sulfate biosynthetic process (GO:0030206)2.63728010
115cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.62577259
116negative regulation of catenin import into nucleus (GO:0035414)2.62534742
117cortical actin cytoskeleton organization (GO:0030866)2.62367375
118glycosphingolipid catabolic process (GO:0046479)2.60609853
119regulation of cartilage development (GO:0061035)2.60570469
120wound healing (GO:0042060)2.57341112
121tooth mineralization (GO:0034505)2.57028432
122insulin-like growth factor receptor signaling pathway (GO:0048009)2.56667368
123membrane protein ectodomain proteolysis (GO:0006509)2.55608757
124regulation of vitamin metabolic process (GO:0030656)2.55462286
125negative regulation of nitric oxide biosynthetic process (GO:0045019)2.54754827
126positive regulation of blood vessel endothelial cell migration (GO:0043536)2.54720772
127response to magnesium ion (GO:0032026)2.54395841
128trabecula formation (GO:0060343)2.54203553
129protein hydroxylation (GO:0018126)2.53466886
130positive regulation of mesenchymal cell proliferation (GO:0002053)2.53215971
131regulation of gastrulation (GO:0010470)2.52607777
132regulation of macrophage cytokine production (GO:0010935)2.52261700
133positive regulation of cartilage development (GO:0061036)2.52242358
134positive regulation of macrophage activation (GO:0043032)2.51706121
135regulation of smooth muscle cell migration (GO:0014910)2.51174936
136* embryonic cranial skeleton morphogenesis (GO:0048701)2.51119688
137* glial cell migration (GO:0008347)2.50021684
138semaphorin-plexin signaling pathway (GO:0071526)2.49213894
139positive regulation of axon extension (GO:0045773)2.45837027
140cortical cytoskeleton organization (GO:0030865)2.44703741
141response to vitamin D (GO:0033280)2.42746621
142mannose metabolic process (GO:0006013)2.42270726
143adherens junction assembly (GO:0034333)2.41531166
144regulation of macrophage chemotaxis (GO:0010758)2.36432566
145cytoskeletal anchoring at plasma membrane (GO:0007016)2.35821647
146positive regulation of chemokine biosynthetic process (GO:0045080)2.35598988

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.75188788
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.99251832
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.70068599
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.43312341
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.30841020
6* CLOCK_20551151_ChIP-Seq_293T_Human2.99263285
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.95823442
8* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.92842771
9* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.82895312
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.75076377
11CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.52722611
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.35691448
13CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.28483331
14CJUN_26792858_Chip-Seq_BT549_Human2.21618072
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.12750720
16HIF1A_21447827_ChIP-Seq_MCF-7_Human1.99578511
17* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.99215621
18EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.99071264
19BRD4_25478319_ChIP-Seq_HGPS_Human1.95459716
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94810628
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.87544588
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86459932
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79938838
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.75527930
25SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.72496873
26SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.72496873
27NRF2_20460467_ChIP-Seq_MEFs_Mouse1.69946458
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.69946458
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.68084868
30* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67030995
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.61052101
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60831021
33* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57447531
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54979251
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54240672
36TP53_20018659_ChIP-ChIP_R1E_Mouse1.51504820
37* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50010458
38SMC1_22415368_ChIP-Seq_MEFs_Mouse1.48782004
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47025702
40ZNF263_19887448_ChIP-Seq_K562_Human1.46569962
41JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45424218
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45220341
43* UBF1/2_26484160_Chip-Seq_HMECs_Human1.44370481
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43743211
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42689223
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.40735851
47ATF3_27146783_Chip-Seq_COLON_Human1.40303585
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40009351
49ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.39580461
50* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38828937
51RACK7_27058665_Chip-Seq_MCF-7_Human1.38212731
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38058216
53SOX2_20726797_ChIP-Seq_SW620_Human1.36891654
54* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36605006
55JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33531314
56* IRF8_27001747_Chip-Seq_BMDM_Mouse1.31676992
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31609482
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.28094916
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.27955375
60* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27740908
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27226172
62TP53_22127205_ChIP-Seq_IMR90_Human1.23115657
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21287199
64TP53_18474530_ChIP-ChIP_U2OS_Human1.21099966
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20192228
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19525049
67* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18776252
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18573839
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18522828
70* LXR_22292898_ChIP-Seq_THP-1_Human1.17601043
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16671165
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16057539
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.15635662
74* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15379338
75VDR_24763502_ChIP-Seq_THP-1_Human1.15039581
76VDR_21846776_ChIP-Seq_THP-1_Human1.14897030
77TBX20_22328084_ChIP-Seq_HEART_Mouse1.14515321
78TBX20_22080862_ChIP-Seq_HEART_Mouse1.14515321
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.10285532
80ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09929140
81KDM2B_26808549_Chip-Seq_DND41_Human1.09572664
82FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09024189
83TCF7_22412390_ChIP-Seq_EML_Mouse1.08585668
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06696548
85VDR_24787735_ChIP-Seq_THP-1_Human1.06591741
86* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06505270
87TP53_16413492_ChIP-PET_HCT116_Human1.06455083
88* TP53_23651856_ChIP-Seq_MEFs_Mouse1.05513489
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.05137012
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04932837
91SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04022645
92KDM2B_26808549_Chip-Seq_K562_Human1.03851313
93* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01956969
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01675183
95ISL1_27105846_Chip-Seq_CPCs_Mouse1.01578449
96* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01562285
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01365395
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01278575
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00152578
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99708541
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99699663
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99280689
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95313232
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95234738
105KDM2B_26808549_Chip-Seq_JURKAT_Human0.94965074
106KLF5_25053715_ChIP-Seq_YYC3_Human0.94390197
107EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93640088
108EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92642239
109RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92642239
110SMAD_19615063_ChIP-ChIP_OVARY_Human0.90778554
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90432844
112IRF8_21731497_ChIP-ChIP_J774_Mouse0.90192356
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89779268
114* SA1_22415368_ChIP-Seq_MEFs_Mouse0.89751270
115NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89272216
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89163148
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89105217
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89102802
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89020718
120CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88343756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.05826902
2MP0005275_abnormal_skin_tensile4.99393811
3MP0005503_abnormal_tendon_morphology4.85197681
4MP0003705_abnormal_hypodermis_morpholog4.22618198
5MP0003279_aneurysm3.47266957
6MP0004272_abnormal_basement_membrane3.12860999
7MP0001958_emphysema3.00980531
8MP0009840_abnormal_foam_cell2.79563220
9MP0006054_spinal_hemorrhage2.76385057
10MP0005623_abnormal_meninges_morphology2.71646650
11MP0005257_abnormal_intraocular_pressure2.33154752
12MP0003566_abnormal_cell_adhesion2.28554343
13MP0009384_cardiac_valve_regurgitation2.10274701
14MP0002060_abnormal_skin_morphology2.09650671
15MP0005023_abnormal_wound_healing2.06317309
16* MP0005508_abnormal_skeleton_morphology2.04596928
17MP0010030_abnormal_orbit_morphology1.91854228
18MP0010352_gastrointestinal_tract_polyps1.83973521
19MP0003385_abnormal_body_wall1.80802262
20MP0003091_abnormal_cell_migration1.77111672
21MP0004510_myositis1.75734357
22MP0003303_peritoneal_inflammation1.72896799
23MP0003172_abnormal_lysosome_physiology1.65935256
24MP0003191_abnormal_cellular_cholesterol1.65928252
25MP0002295_abnormal_pulmonary_circulatio1.63654247
26MP0009250_abnormal_appendicular_skeleto1.60181260
27MP0001542_abnormal_bone_strength1.58524793
28MP0009053_abnormal_anal_canal1.57487954
29MP0000767_abnormal_smooth_muscle1.53531752
30MP0006082_CNS_inflammation1.53446755
31MP0003436_decreased_susceptibility_to1.47443557
32MP0001243_abnormal_dermal_layer1.46994074
33MP0000604_amyloidosis1.43802864
34MP0002282_abnormal_trachea_morphology1.41961570
35MP0002108_abnormal_muscle_morphology1.40608194
36* MP0000733_abnormal_muscle_development1.39980163
37MP0003950_abnormal_plasma_membrane1.39107843
38* MP0002896_abnormal_bone_mineralization1.38467580
39MP0010368_abnormal_lymphatic_system1.34839528
40* MP0005390_skeleton_phenotype1.30413551
41MP0000534_abnormal_ureter_morphology1.27805176
42MP0003075_altered_response_to1.27233196
43MP0005076_abnormal_cell_differentiation1.27038288
44MP0003942_abnormal_urinary_system1.26665392
45MP0002877_abnormal_melanocyte_morpholog1.24342173
46MP0001299_abnormal_eye_distance/1.22198937
47MP0003828_pulmonary_edema1.20811345
48MP0003941_abnormal_skin_development1.19426363
49* MP0002115_abnormal_skeleton_extremities1.18217934
50MP0005451_abnormal_body_composition1.17768489
51MP0005409_darkened_coat_color1.17501704
52MP0003329_amyloid_beta_deposits1.16933382
53MP0005165_increased_susceptibility_to1.16211872
54MP0001849_ear_inflammation1.13930339
55MP0003300_gastrointestinal_ulcer1.11148820
56MP0004947_skin_inflammation1.10715596
57MP0003283_abnormal_digestive_organ1.09520356
58MP0003448_altered_tumor_morphology1.08997074
59* MP0000163_abnormal_cartilage_morphology1.08253458
60* MP0002998_abnormal_bone_remodeling1.05075362
61MP0009278_abnormal_bone_marrow1.04703233
62MP0004134_abnormal_chest_morphology1.04506358
63MP0008260_abnormal_autophagy1.03125271
64* MP0000428_abnormal_craniofacial_morphol1.02270076
65MP0002254_reproductive_system_inflammat1.01512019
66MP0001879_abnormal_lymphatic_vessel1.00042384
67* MP0003115_abnormal_respiratory_system0.99532516
68MP0002148_abnormal_hypersensitivity_rea0.98357530
69* MP0002113_abnormal_skeleton_development0.98344053
70MP0000858_altered_metastatic_potential0.98139225
71* MP0002932_abnormal_joint_morphology0.97215965
72MP0005164_abnormal_response_to0.97094049
73MP0000049_abnormal_middle_ear0.97066045
74* MP0001533_abnormal_skeleton_physiology0.93069473
75MP0000537_abnormal_urethra_morphology0.90846161
76MP0001348_abnormal_lacrimal_gland0.90027472
77MP0000750_abnormal_muscle_regeneration0.89283917
78MP0002249_abnormal_larynx_morphology0.87923068
79MP0000013_abnormal_adipose_tissue0.87286425
80MP0002128_abnormal_blood_circulation0.87193875
81MP0001915_intracranial_hemorrhage0.85891604
82MP0003453_abnormal_keratinocyte_physiol0.85550773
83MP0009785_altered_susceptibility_to0.85490105
84* MP0001614_abnormal_blood_vessel0.84385842
85* MP0003755_abnormal_palate_morphology0.84280164
86* MP0002419_abnormal_innate_immunity0.83784606
87MP0001216_abnormal_epidermal_layer0.83617835
88* MP0002168_other_aberrant_phenotype0.82934296
89MP0009764_decreased_sensitivity_to0.82888528
90* MP0003795_abnormal_bone_structure0.82055518
91MP0004883_abnormal_blood_vessel0.81472626
92MP0005197_abnormal_uvea_morphology0.81177146
93* MP0000432_abnormal_head_morphology0.81029819
94MP0000516_abnormal_urinary_system0.81004362
95MP0005367_renal/urinary_system_phenotyp0.81004362
96MP0003634_abnormal_glial_cell0.79956663
97MP0000249_abnormal_blood_vessel0.77737694
98MP0004858_abnormal_nervous_system0.77267403
99* MP0002109_abnormal_limb_morphology0.76163669
100MP0008004_abnormal_stomach_pH0.75986602
101MP0000343_altered_response_to0.75854483
102MP0002111_abnormal_tail_morphology0.75380478
103MP0005248_abnormal_Harderian_gland0.74653960
104* MP0003935_abnormal_craniofacial_develop0.73647388
105* MP0002933_joint_inflammation0.71409024
106MP0002233_abnormal_nose_morphology0.71221730
107* MP0002925_abnormal_cardiovascular_devel0.70605307
108* MP0002116_abnormal_craniofacial_bone0.70589857
109MP0005166_decreased_susceptibility_to0.70052170
110MP0005167_abnormal_blood-brain_barrier0.69996879
111MP0004233_abnormal_muscle_weight0.69476500
112MP0005464_abnormal_platelet_physiology0.69215369
113* MP0001175_abnormal_lung_morphology0.68120875
114MP0000751_myopathy0.67821851
115MP0000762_abnormal_tongue_morphology0.67145011
116MP0001853_heart_inflammation0.66934975
117MP0005193_abnormal_anterior_eye0.66636901
118MP0003937_abnormal_limbs/digits/tail_de0.64229954
119MP0000579_abnormal_nail_morphology0.64197902
120MP0002796_impaired_skin_barrier0.62863869
121MP0000920_abnormal_myelination0.62610831
122MP0002092_abnormal_eye_morphology0.62318306
123MP0005171_absent_coat_pigmentation0.61455867
124MP0005058_abnormal_lysosome_morphology0.60676592
125MP0010771_integument_phenotype0.60536188
126MP0000003_abnormal_adipose_tissue0.59248168
127MP0000467_abnormal_esophagus_morphology0.58728726
128MP0010234_abnormal_vibrissa_follicle0.58499370
129MP0005595_abnormal_vascular_smooth0.58435320
130MP0010307_abnormal_tumor_latency0.57605317
131MP0004197_abnormal_fetal_growth/weight/0.55983666
132* MP0002697_abnormal_eye_size0.54180731
133MP0005388_respiratory_system_phenotype0.53700536
134MP0002133_abnormal_respiratory_system0.53700536

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.24013239
2Premature rupture of membranes (HP:0001788)7.77610075
3Ankle contracture (HP:0006466)5.32446665
4Aortic dissection (HP:0002647)5.00457546
5Atrophic scars (HP:0001075)4.88402692
6Shallow orbits (HP:0000586)4.84023486
7Peritonitis (HP:0002586)4.74554370
8Broad metatarsal (HP:0001783)4.39715643
9Soft skin (HP:0000977)4.31675601
10Cerebral aneurysm (HP:0004944)4.20626210
11Fragile skin (HP:0001030)4.08633836
12Cervical subluxation (HP:0003308)4.05268332
13Abnormality of glycolipid metabolism (HP:0010969)3.94497734
14Abnormality of liposaccharide metabolism (HP:0010968)3.94497734
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.94497734
16Bladder diverticulum (HP:0000015)3.88851979
17Abnormality of dentin (HP:0010299)3.88527313
18Aortic aneurysm (HP:0004942)3.77078143
19Dilatation of the ascending aorta (HP:0005111)3.70389261
20Follicular hyperkeratosis (HP:0007502)3.69969292
21Vertebral compression fractures (HP:0002953)3.57152754
22Mitral valve prolapse (HP:0001634)3.52714029
23Type 1 muscle fiber predominance (HP:0003803)3.49404995
24Neonatal short-limb short stature (HP:0008921)3.44403110
25Blue sclerae (HP:0000592)3.43485214
26Genu recurvatum (HP:0002816)3.37802779
27Wormian bones (HP:0002645)3.23652048
28Biconcave vertebral bodies (HP:0004586)3.22084219
29Spinal rigidity (HP:0003306)3.11311370
30Wrist flexion contracture (HP:0001239)3.03363544
31Dysostosis multiplex (HP:0000943)2.98784384
32Vascular tortuosity (HP:0004948)2.85548474
33Neurofibrillary tangles (HP:0002185)2.84536581
34Slender build (HP:0001533)2.83834443
35Increased connective tissue (HP:0009025)2.82120971
36Hyperextensible skin (HP:0000974)2.75312769
37Abnormal delivery (HP:0001787)2.70145574
38Osteolytic defects of the hand bones (HP:0009699)2.65170915
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.65170915
40Ulnar bowing (HP:0003031)2.63505310
41Natal tooth (HP:0000695)2.59648992
42Arterial tortuosity (HP:0005116)2.56481055
43Bowel diverticulosis (HP:0005222)2.56154146
44Abnormality of the acetabulum (HP:0003170)2.54603705
45Elbow flexion contracture (HP:0002987)2.51715858
46Urinary glycosaminoglycan excretion (HP:0003541)2.49386849
47Mucopolysacchariduria (HP:0008155)2.49386849
48Abnormality of mucopolysaccharide metabolism (HP:0011020)2.48398436
49Abnormality of polysaccharide metabolism (HP:0011012)2.48398436
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.48398436
51Spondylolisthesis (HP:0003302)2.47218940
52Deviation of the hallux (HP:0010051)2.47015677
53Nuclear cataract (HP:0100018)2.44203764
54Aneurysm (HP:0002617)2.42416986
55Achilles tendon contracture (HP:0001771)2.42320730
56Joint laxity (HP:0001388)2.39986947
57Mildly elevated creatine phosphokinase (HP:0008180)2.37985028
58Wide anterior fontanel (HP:0000260)2.37893566
59Camptodactyly of toe (HP:0001836)2.37280618
60Ectopia lentis (HP:0001083)2.35602460
61Hallux valgus (HP:0001822)2.35528602
62Joint stiffness (HP:0001387)2.32771787
63Abnormality of the peritoneum (HP:0002585)2.30157932
64Cerebral inclusion bodies (HP:0100314)2.29582091
65Increased variability in muscle fiber diameter (HP:0003557)2.27743769
66Nonimmune hydrops fetalis (HP:0001790)2.25018399
67Thin bony cortex (HP:0002753)2.22322531
68Vacuolated lymphocytes (HP:0001922)2.19764833
69Infantile muscular hypotonia (HP:0008947)2.19060400
70Radial bowing (HP:0002986)2.17234673
71Short 4th metacarpal (HP:0010044)2.14806970
72Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14806970
73Increased cerebral lipofuscin (HP:0011813)2.14122298
74Femoral bowing (HP:0002980)2.13847960
75Tibial bowing (HP:0002982)2.13639179
76Myocardial infarction (HP:0001658)2.13155978
77Overgrowth (HP:0001548)2.12747722
78Coronal craniosynostosis (HP:0004440)2.11782074
79Bowed forearm bones (HP:0003956)2.11331096
80Bowing of the arm (HP:0006488)2.11331096
81Abnormality of the Achilles tendon (HP:0005109)2.10371554
82Loss of speech (HP:0002371)2.09106992
83Asymmetry of the thorax (HP:0001555)2.07866723
84Osteoarthritis (HP:0002758)2.07304187
85Mesomelia (HP:0003027)2.06295237
86Axonal loss (HP:0003447)2.05850533
87Buphthalmos (HP:0000557)2.05620688
88Mitral regurgitation (HP:0001653)2.05446540
89Hyperacusis (HP:0010780)2.05339472
90Spinal cord lesions (HP:0100561)2.04680671
91Syringomyelia (HP:0003396)2.04680671
92Striae distensae (HP:0001065)2.04309824
93Alopecia of scalp (HP:0002293)2.03294915
94Broad ribs (HP:0000885)2.01775696
95Breech presentation (HP:0001623)2.00637142
96Abnormality of skeletal muscle fiber size (HP:0012084)1.98648761
97Distal lower limb amyotrophy (HP:0008944)1.94814668
98Hand muscle atrophy (HP:0009130)1.94275639
99Mitral stenosis (HP:0001718)1.94067679
100Bell-shaped thorax (HP:0001591)1.93773634
101Hypoventilation (HP:0002791)1.92956482
102Short nail (HP:0001799)1.92227488
103Long toe (HP:0010511)1.91734156
104Knee flexion contracture (HP:0006380)1.91420851
105Ovoid vertebral bodies (HP:0003300)1.90553241
106Systemic lupus erythematosus (HP:0002725)1.89854614
107Venous abnormality (HP:0002624)1.89398246
108Flexion contracture of toe (HP:0005830)1.88528000
109Joint contractures involving the joints of the feet (HP:0100492)1.88528000
110Morphological abnormality of the middle ear (HP:0008609)1.88021237
111Disproportionate tall stature (HP:0001519)1.85363012
112Distal lower limb muscle weakness (HP:0009053)1.85323315
113Broad long bones (HP:0005622)1.84015628
114Abnormality of the 4th metacarpal (HP:0010012)1.80656421
115Asymmetric septal hypertrophy (HP:0001670)1.80207396
116Inguinal hernia (HP:0000023)1.78925125
117Osteopenia (HP:0000938)1.78553596
118Coxa vara (HP:0002812)1.78172411
119Delayed closure of the anterior fontanelle (HP:0001476)1.76244947
120Venous insufficiency (HP:0005293)1.75728159
121Aortic valve stenosis (HP:0001650)1.75081378
122Increased density of long bones (HP:0006392)1.74168059
123Round ear (HP:0100830)1.73687865
124Platyspondyly (HP:0000926)1.73302605
125Delayed cranial suture closure (HP:0000270)1.73175623
126Turricephaly (HP:0000262)1.72873894
127Milia (HP:0001056)1.72847988
128Protruding ear (HP:0000411)1.71359633
129Upper limb amyotrophy (HP:0009129)1.70458654
130Distal upper limb amyotrophy (HP:0007149)1.70458654
131Aortic regurgitation (HP:0001659)1.69829811
132Absent frontal sinuses (HP:0002688)1.69556181
133Abnormality of the distal phalanges of the toes (HP:0010182)1.69328652
134Generalized amyotrophy (HP:0003700)1.69093049
135Thin skin (HP:0000963)1.67031530
136J-shaped sella turcica (HP:0002680)1.66000648
137Cardiovascular calcification (HP:0011915)1.65216709
138Thick nail (HP:0001805)1.64924637
139Increased neuronal autofluorescent lipopigment (HP:0002074)1.62949455
140Broad face (HP:0000283)1.62092673
141Difficulty climbing stairs (HP:0003551)1.62010407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.90957152
2TRIB34.53232048
3PDGFRA3.62980667
4TTN3.46567915
5ERN13.32221905
6PKN23.12584966
7IRAK33.09138975
8LATS12.95836351
9SIK12.55994493
10NME22.52705422
11RIPK12.45793510
12EPHB22.37512705
13LATS22.36348252
14BMX2.11446647
15PTK61.98846286
16MAP3K101.86130726
17TGFBR21.80697739
18PAK21.80369369
19PTK21.73274946
20PAK41.68656881
21EPHA31.65899170
22PRPF4B1.65001530
23FER1.55032573
24LRRK21.48042414
25TAOK21.43563782
26MET1.39888550
27STK31.39223141
28EPHB11.38229241
29TRPM71.34515578
30PDGFRB1.33806977
31EPHA21.33583025
32RPS6KA41.27377531
33TESK11.24527618
34ARAF1.24137638
35GRK71.20561962
36FGFR11.19934901
37MAP3K141.18959943
38PIM21.18300847
39EEF2K1.17784909
40FGFR41.16978030
41DMPK1.16788988
42NEK91.16181190
43RPS6KA21.10324374
44TIE11.10302862
45MAP3K131.10067023
46PTK2B1.09347328
47PAK31.09117255
48ZAP701.03831941
49SMG11.02166958
50ILK1.01899852
51MYLK1.01498250
52MTOR0.97849893
53MAP3K60.96477871
54MST1R0.96157616
55TBK10.91227310
56STK380.86896263
57ROCK10.86331390
58MATK0.84937877
59CDK60.79425141
60KDR0.78942483
61JAK10.75819067
62DAPK30.75207719
63KIT0.74950751
64LIMK10.74783355
65MOS0.73364723
66ABL20.72925036
67FLT30.72492167
68MAP2K10.70029264
69TGFBR10.69988008
70JAK30.69146235
71NTRK10.68990702
72DYRK1B0.67585785
73MAPK70.67485536
74MAP3K110.66515116
75FGFR20.65349941
76CHUK0.62441562
77CAMK1D0.61747230
78PIK3CG0.61314526
79FGFR30.60967928
80MAP3K10.60892224
81RET0.60083334
82KSR20.60067175
83RPS6KL10.59295520
84RPS6KC10.59295520
85ROCK20.58097136
86STK38L0.57553815
87INSR0.56994103
88ICK0.56745162
89ERBB30.56005692
90MAP3K30.55844118
91TESK20.55689001
92FRK0.55541175
93SCYL20.54347441
94PIK3CA0.53555922
95CLK10.53541288
96FGR0.52918251
97CDK120.52257812
98PAK10.50130962
99TYK20.49388547
100PDPK10.47687271
101ERBB20.44448946
102PRKD10.43759304
103PRKG20.43062560
104* SRC0.42968915
105MAPKAPK30.42309223
106BLK0.39899887
107MAP2K30.39076172
108STK100.38736704
109RPS6KA60.38590944
110ABL10.38560358
111PAK60.37302977
112CDC42BPA0.37174899
113LMTK20.36256777
114MAP3K80.36240109
115PRKCH0.35903424
116TYRO30.35252270
117IKBKB0.35149633
118CSF1R0.35125080
119MARK20.34721304
120PRKD20.34284409
121BRAF0.34240956
122MAPKAPK20.34201262
123ERBB40.33395942
124CSK0.32771833
125GSK3A0.32671516
126EGFR0.32396880
127CAMK1G0.31732167
128NUAK10.31265084
129TAOK10.28032321
130CAMKK10.27892651
131PLK20.27609460
132MAPK10.27374006

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.25730183
2Focal adhesion_Homo sapiens_hsa045102.95204301
3Amoebiasis_Homo sapiens_hsa051462.47747585
4Malaria_Homo sapiens_hsa051442.44153795
5AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.41527132
6Proteoglycans in cancer_Homo sapiens_hsa052052.39097441
7Protein digestion and absorption_Homo sapiens_hsa049742.36628420
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.23884360
9Bladder cancer_Homo sapiens_hsa052192.20207310
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.08273119
11Small cell lung cancer_Homo sapiens_hsa052222.06545883
12Adherens junction_Homo sapiens_hsa045201.99873358
13Chronic myeloid leukemia_Homo sapiens_hsa052201.78298730
14TGF-beta signaling pathway_Homo sapiens_hsa043501.78291178
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77538118
16Basal cell carcinoma_Homo sapiens_hsa052171.74882345
17MicroRNAs in cancer_Homo sapiens_hsa052061.66841025
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.65534812
19Hippo signaling pathway_Homo sapiens_hsa043901.65378299
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51365230
21PI3K-Akt signaling pathway_Homo sapiens_hsa041511.49268930
22Dilated cardiomyopathy_Homo sapiens_hsa054141.41615542
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.38637233
24Toxoplasmosis_Homo sapiens_hsa051451.38242253
25Melanoma_Homo sapiens_hsa052181.36781958
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.36563342
27Leishmaniasis_Homo sapiens_hsa051401.35430194
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31113998
29Hedgehog signaling pathway_Homo sapiens_hsa043401.30093547
30Viral myocarditis_Homo sapiens_hsa054161.23772946
31Pancreatic cancer_Homo sapiens_hsa052121.23760059
32* TNF signaling pathway_Homo sapiens_hsa046681.22296611
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.18887173
34p53 signaling pathway_Homo sapiens_hsa041151.17425195
35Shigellosis_Homo sapiens_hsa051311.16741176
36Phagosome_Homo sapiens_hsa041451.12759958
37Lysosome_Homo sapiens_hsa041421.10249026
38Vibrio cholerae infection_Homo sapiens_hsa051101.09345921
39Prostate cancer_Homo sapiens_hsa052151.08066169
40Pathways in cancer_Homo sapiens_hsa052001.06611290
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06387123
42Salmonella infection_Homo sapiens_hsa051321.06180059
43Glioma_Homo sapiens_hsa052141.05761224
44Complement and coagulation cascades_Homo sapiens_hsa046101.05255540
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01907183
46Osteoclast differentiation_Homo sapiens_hsa043800.99447540
47Staphylococcus aureus infection_Homo sapiens_hsa051500.98318384
48Pertussis_Homo sapiens_hsa051330.97358350
49Notch signaling pathway_Homo sapiens_hsa043300.96257315
50Platelet activation_Homo sapiens_hsa046110.95468028
51Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94989561
52Galactose metabolism_Homo sapiens_hsa000520.94198691
53Apoptosis_Homo sapiens_hsa042100.93284863
54HTLV-I infection_Homo sapiens_hsa051660.92733565
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90960790
56Sphingolipid metabolism_Homo sapiens_hsa006000.89325034
57Tuberculosis_Homo sapiens_hsa051520.88778391
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87297100
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85470919
60Rap1 signaling pathway_Homo sapiens_hsa040150.85253875
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85196388
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.85023334
63Hepatitis B_Homo sapiens_hsa051610.85022577
64Tight junction_Homo sapiens_hsa045300.84545117
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82185053
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81975109
67Legionellosis_Homo sapiens_hsa051340.80189931
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78276959
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.77332156
70Colorectal cancer_Homo sapiens_hsa052100.75848670
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73114763
72Mineral absorption_Homo sapiens_hsa049780.72852268
73Axon guidance_Homo sapiens_hsa043600.72635947
74Wnt signaling pathway_Homo sapiens_hsa043100.72202359
75HIF-1 signaling pathway_Homo sapiens_hsa040660.71882362
76Renal cell carcinoma_Homo sapiens_hsa052110.69642605
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68496210
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68180774
79Prion diseases_Homo sapiens_hsa050200.67349571
80Insulin resistance_Homo sapiens_hsa049310.67208084
81Endometrial cancer_Homo sapiens_hsa052130.67197847
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.66157609
83Hematopoietic cell lineage_Homo sapiens_hsa046400.65242087
84Caffeine metabolism_Homo sapiens_hsa002320.65015956
85African trypanosomiasis_Homo sapiens_hsa051430.62648710
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.62074105
87Viral carcinogenesis_Homo sapiens_hsa052030.61523776
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.61339653
89Rheumatoid arthritis_Homo sapiens_hsa053230.60544856
90Melanogenesis_Homo sapiens_hsa049160.60009247
91Thyroid cancer_Homo sapiens_hsa052160.59665543
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.56892289
93Chemokine signaling pathway_Homo sapiens_hsa040620.56610464
94Renin-angiotensin system_Homo sapiens_hsa046140.55998317
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55324174
96VEGF signaling pathway_Homo sapiens_hsa043700.54538637
97FoxO signaling pathway_Homo sapiens_hsa040680.54333528
98mTOR signaling pathway_Homo sapiens_hsa041500.54213416
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53863903
100* GnRH signaling pathway_Homo sapiens_hsa049120.52582384
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51728244
102Acute myeloid leukemia_Homo sapiens_hsa052210.50651166
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50609212
104Estrogen signaling pathway_Homo sapiens_hsa049150.50392805
105N-Glycan biosynthesis_Homo sapiens_hsa005100.49002225
106Endocytosis_Homo sapiens_hsa041440.48330840
107ErbB signaling pathway_Homo sapiens_hsa040120.47560304
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46586537
109Sulfur metabolism_Homo sapiens_hsa009200.46084365
110Influenza A_Homo sapiens_hsa051640.45394199
111Prolactin signaling pathway_Homo sapiens_hsa049170.45328287
112Gap junction_Homo sapiens_hsa045400.44086111
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42782118
114PPAR signaling pathway_Homo sapiens_hsa033200.42196146
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41894248
116Hepatitis C_Homo sapiens_hsa051600.41508127
117Measles_Homo sapiens_hsa051620.41354701
118Non-small cell lung cancer_Homo sapiens_hsa052230.41318376
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39226660
120Other glycan degradation_Homo sapiens_hsa005110.38958187
121Lysine degradation_Homo sapiens_hsa003100.38653172
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.37555707
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37534081
124Ras signaling pathway_Homo sapiens_hsa040140.37418515

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