MMP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)5.20330185
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.78337700
3sarcomere organization (GO:0045214)4.75732129
4negative regulation of potassium ion transmembrane transport (GO:1901380)4.57627944
5cardiac myofibril assembly (GO:0055003)4.50778522
6ventricular cardiac muscle cell action potential (GO:0086005)4.50180801
7cell communication involved in cardiac conduction (GO:0086065)4.00508616
8surfactant homeostasis (GO:0043129)3.81219180
9myofibril assembly (GO:0030239)3.68084070
10plasma membrane repair (GO:0001778)3.63707822
11regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.60858879
12NADH metabolic process (GO:0006734)3.56754975
13regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.56729234
14planar cell polarity pathway involved in neural tube closure (GO:0090179)3.56538032
15cardiac muscle contraction (GO:0060048)3.52869500
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.51853101
17heart trabecula formation (GO:0060347)3.51528595
18regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.51270503
19carnitine shuttle (GO:0006853)3.49180419
20regulation of cardioblast differentiation (GO:0051890)3.45624763
21actomyosin structure organization (GO:0031032)3.41902689
22fatty acid transmembrane transport (GO:1902001)3.33504272
23cardiac muscle cell development (GO:0055013)3.33458187
24cardiac cell development (GO:0055006)3.30392809
25alpha-linolenic acid metabolic process (GO:0036109)3.29745133
26cell communication by electrical coupling (GO:0010644)3.26567607
27tricarboxylic acid cycle (GO:0006099)3.23125034
28regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.22577624
29regulation of bile acid biosynthetic process (GO:0070857)3.21719003
30positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.21045176
31chemical homeostasis within a tissue (GO:0048875)3.19063029
32intestinal absorption (GO:0050892)3.17984410
33ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.15917039
34regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.12479178
35regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.12090611
36actin-myosin filament sliding (GO:0033275)3.04157347
37muscle filament sliding (GO:0030049)3.04157347
38lysine catabolic process (GO:0006554)3.03554444
39lysine metabolic process (GO:0006553)3.03554444
40regulation of actin filament-based movement (GO:1903115)3.03388324
41cell junction maintenance (GO:0034331)3.02429518
42proline biosynthetic process (GO:0006561)3.02349276
43atrial septum morphogenesis (GO:0060413)3.01124654
44cardiac muscle tissue morphogenesis (GO:0055008)2.98975647
45proline metabolic process (GO:0006560)2.98887687
46very-low-density lipoprotein particle assembly (GO:0034379)2.98648894
47negative regulation of catenin import into nucleus (GO:0035414)2.98261695
48regulation of heart rate by cardiac conduction (GO:0086091)2.98217937
49cellular component maintenance (GO:0043954)2.97608977
50protein retention in ER lumen (GO:0006621)2.96156542
51epithelial cell-cell adhesion (GO:0090136)2.96133750
52hemidesmosome assembly (GO:0031581)2.95659043
53cardiac muscle cell action potential involved in contraction (GO:0086002)2.90673715
54cardiac muscle cell action potential (GO:0086001)2.87778786
55protein carboxylation (GO:0018214)2.87580792
56peptidyl-glutamic acid carboxylation (GO:0017187)2.87580792
57regulation of membrane repolarization (GO:0060306)2.87410456
58maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86490088
59epithelial cell differentiation involved in prostate gland development (GO:0060742)2.83881334
60adult heart development (GO:0007512)2.83649600
61embryonic retina morphogenesis in camera-type eye (GO:0060059)2.83606243
62urea cycle (GO:0000050)2.83445445
63plasma lipoprotein particle assembly (GO:0034377)2.81506207
64membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.81026051
65cytoskeletal anchoring at plasma membrane (GO:0007016)2.80078647
66regulation of cholesterol biosynthetic process (GO:0045540)2.79498368
67urea metabolic process (GO:0019627)2.79081228
68negative regulation of striated muscle cell apoptotic process (GO:0010664)2.78575380
692-oxoglutarate metabolic process (GO:0006103)2.77415525
70coronary vasculature morphogenesis (GO:0060977)2.74834771
71cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.74776552
72negative regulation of cell size (GO:0045792)2.73846319
73glucose 6-phosphate metabolic process (GO:0051156)2.73333234
74creatine metabolic process (GO:0006600)2.71893368
75cardiac conduction (GO:0061337)2.71144866
76cardiac muscle hypertrophy (GO:0003300)2.70435260
77apoptotic process involved in morphogenesis (GO:0060561)2.68915643
78regulation of fatty acid oxidation (GO:0046320)2.68716151
79muscle tissue morphogenesis (GO:0060415)2.68692180
80regulation of skeletal muscle contraction (GO:0014819)2.67947865
81lung epithelium development (GO:0060428)2.67407623
82membrane repolarization during action potential (GO:0086011)2.67249255
83cardiac muscle cell proliferation (GO:0060038)2.65479308
84venous blood vessel morphogenesis (GO:0048845)2.64534317
85cell-cell junction maintenance (GO:0045217)2.64500886
86paraxial mesoderm development (GO:0048339)2.64256359
87actin-mediated cell contraction (GO:0070252)2.63835928
88negative regulation of myotube differentiation (GO:0010832)2.62715490
89convergent extension (GO:0060026)2.62464147
90semaphorin-plexin signaling pathway (GO:0071526)2.62171274
91aspartate family amino acid catabolic process (GO:0009068)2.61820148
92endocardial cushion development (GO:0003197)2.60590711
93fatty acid beta-oxidation (GO:0006635)2.59425543
94acetyl-CoA metabolic process (GO:0006084)2.58408763
95regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.57685868
96endocrine process (GO:0050886)2.57685868
97regulation of systemic arterial blood pressure by hormone (GO:0001990)2.57685868
98desmosome organization (GO:0002934)2.55522128
99protein-lipid complex assembly (GO:0065005)2.55514496
100striated muscle contraction (GO:0006941)2.55395922
101regulation of p38MAPK cascade (GO:1900744)2.55291655
102regulation of the force of heart contraction (GO:0002026)2.55072988
103heart valve formation (GO:0003188)2.54436720
104regulation of heart rate (GO:0002027)2.54424810
105regulation of cholesterol esterification (GO:0010872)2.53648260
106striated muscle hypertrophy (GO:0014897)2.52799232
107regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.52369217
108potassium ion export (GO:0071435)2.52262593
109positive regulation of fatty acid beta-oxidation (GO:0032000)2.52245419
110atrioventricular valve morphogenesis (GO:0003181)2.51356215
111branching involved in salivary gland morphogenesis (GO:0060445)2.50909368
112COPI coating of Golgi vesicle (GO:0048205)2.49731326
113Golgi transport vesicle coating (GO:0048200)2.49731326
114regulation of cholesterol homeostasis (GO:2000188)2.49663753
115positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.49258867
116cellular response to prostaglandin stimulus (GO:0071379)2.48708900
117renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.48420674
118cardiac right ventricle morphogenesis (GO:0003215)2.47258783
1194-hydroxyproline metabolic process (GO:0019471)2.47149304
120regulation of fatty acid beta-oxidation (GO:0031998)2.46840874
121regulation of hippo signaling (GO:0035330)2.44809347
122establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.43629399
123regulation of sarcomere organization (GO:0060297)2.43486738
124negative regulation of protein localization to cell surface (GO:2000009)2.43347192
125carnitine transmembrane transport (GO:1902603)2.42837390
126cell migration involved in sprouting angiogenesis (GO:0002042)2.42509744
127triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.41150688
128positive regulation of glycogen biosynthetic process (GO:0045725)2.40505684
129regulation of apoptotic cell clearance (GO:2000425)2.40106869
130nitrogen cycle metabolic process (GO:0071941)2.39871359
131regulation of protein activation cascade (GO:2000257)2.39729502
132regulation of cholesterol metabolic process (GO:0090181)2.39298453
133cardiac chamber formation (GO:0003207)2.39207422
134regulation of striated muscle contraction (GO:0006942)2.38798691
135layer formation in cerebral cortex (GO:0021819)2.38796293
136cellular ketone body metabolic process (GO:0046950)2.37924123
137gap junction assembly (GO:0016264)2.37032451
138diacylglycerol metabolic process (GO:0046339)2.36825458
139plasma lipoprotein particle remodeling (GO:0034369)2.35642027
140protein-lipid complex remodeling (GO:0034368)2.35642027
141macromolecular complex remodeling (GO:0034367)2.35642027
142sodium ion export (GO:0071436)2.35525812
143regulation of complement activation (GO:0030449)2.34866113
144renal filtration (GO:0097205)2.34267170
145actin filament-based movement (GO:0030048)2.33877271
146regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.33796235
147outflow tract septum morphogenesis (GO:0003148)2.33393294
148heart valve morphogenesis (GO:0003179)2.33244336
149embryonic foregut morphogenesis (GO:0048617)2.32980888
150adherens junction assembly (GO:0034333)2.32787939
151receptor guanylyl cyclase signaling pathway (GO:0007168)2.31847885
152basement membrane organization (GO:0071711)2.31053378
153regulation of cardiac muscle cell contraction (GO:0086004)2.30776894
154cardiac muscle hypertrophy in response to stress (GO:0014898)2.30515721
155muscle hypertrophy in response to stress (GO:0003299)2.30515721
156cardiac muscle adaptation (GO:0014887)2.30515721
157glutamine family amino acid biosynthetic process (GO:0009084)2.30442109
158positive regulation of fatty acid oxidation (GO:0046321)2.30340042
159midgut development (GO:0007494)2.30091467
160negative regulation of fibrinolysis (GO:0051918)2.29784590
161negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.29778264
162regulation of systemic arterial blood pressure (GO:0003073)2.28052051
163Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.27288071
164epoxygenase P450 pathway (GO:0019373)2.25816601
165angiotensin maturation (GO:0002003)2.24049320

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.75749318
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.72782411
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.24597641
4ZNF263_19887448_ChIP-Seq_K562_Human3.05615969
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.74703888
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.60854398
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.58282067
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.49561660
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.42026517
10* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.40887778
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.30382238
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.26636082
13CLOCK_20551151_ChIP-Seq_293T_Human2.26372839
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.20264927
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.99710109
16* TBX20_22080862_ChIP-Seq_HEART_Mouse1.90129153
17* TBX20_22328084_ChIP-Seq_HEART_Mouse1.90129153
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89330936
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84125731
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.83147563
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.66374378
22* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58140917
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54540917
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52331223
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52283010
26* KDM2B_26808549_Chip-Seq_K562_Human1.49709810
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49218243
28* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48478939
29* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48049431
30* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46130048
31* RACK7_27058665_Chip-Seq_MCF-7_Human1.44069449
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42867525
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42808828
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42798795
35LXR_22292898_ChIP-Seq_THP-1_Human1.42019218
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42007715
37* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41054411
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40988745
39* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40843803
40* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40843803
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39325251
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.38893804
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36300077
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35903666
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33899027
46* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32642592
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31218273
48AHR_22903824_ChIP-Seq_MCF-7_Human1.31020992
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31015303
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29793690
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28901384
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.28225238
53CDX2_20551321_ChIP-Seq_CACO-2_Human1.27707159
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27513471
55TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27484567
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.27257165
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27192851
58DROSHA_22980978_ChIP-Seq_HELA_Human1.27161664
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.26625194
60ISL1_27105846_Chip-Seq_CPCs_Mouse1.26532354
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26159243
62* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25314159
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24010870
64* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23660728
65* FOXO3_23340844_ChIP-Seq_DLD1_Human1.22386733
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21858538
67* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21113302
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.20631237
69SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20401861
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19790671
71POU5F1_16518401_ChIP-PET_MESCs_Mouse1.18400651
72GATA6_25053715_ChIP-Seq_YYC3_Human1.17356560
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17278639
74* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16517226
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16295919
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16261427
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15446242
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14952877
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.12748285
80SMC4_20622854_ChIP-Seq_HELA_Human1.12439924
81KDM2B_26808549_Chip-Seq_DND41_Human1.12247743
82* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11534020
83SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10930027
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09588497
85* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09397163
86TCF7_22412390_ChIP-Seq_EML_Mouse1.08055081
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05855380
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05375959
89* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05305361
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.04879259
91* EZH2_27294783_Chip-Seq_ESCs_Mouse1.04417412
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04125399
93* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03967175
94GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.03682088
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03192458
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02286848
97SOX2_20726797_ChIP-Seq_SW620_Human1.02111344
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.01885108
99* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01558583
100* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00365338
101CREB1_26743006_Chip-Seq_LNCaP_Human1.00286743
102GATA4_25053715_ChIP-Seq_YYC3_Human1.00119014
103AR_21572438_ChIP-Seq_LNCaP_Human0.99642637
104RING1B_27294783_Chip-Seq_ESCs_Mouse0.99444891
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99287995
106TP53_22127205_ChIP-Seq_IMR90_Human0.99031810
107TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98558000
108* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98354562
109SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98254319
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97501937
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97403248
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96870817
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96847705
114TP53_20018659_ChIP-ChIP_R1E_Mouse0.96787558
115CTCF_27219007_Chip-Seq_Bcells_Human0.96350683
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95955925
117* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95712493
118GATA2_21666600_ChIP-Seq_HMVEC_Human0.94954003
119RNF2_27304074_Chip-Seq_ESCs_Mouse0.94820136
120P68_20966046_ChIP-Seq_HELA_Human0.94640727
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94118851
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93480679
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93352695
124ATF3_27146783_Chip-Seq_COLON_Human0.93343112
125STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.92520656
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92404334
127* EZH2_27304074_Chip-Seq_ESCs_Mouse0.92065295
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91987487
129* TET1_21490601_ChIP-Seq_MESCs_Mouse0.91926951
130SA1_27219007_Chip-Seq_ERYTHROID_Human0.91907402
131* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91514630

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.28998245
2MP0002837_dystrophic_cardiac_calcinosis4.10415521
3MP0000751_myopathy3.43403972
4MP0004215_abnormal_myocardial_fiber2.82641631
5MP0004036_abnormal_muscle_relaxation2.80574202
6MP0004272_abnormal_basement_membrane2.77823559
7MP0004264_abnormal_extraembryonic_tissu2.59201737
8MP0005330_cardiomyopathy2.58403389
9MP0002139_abnormal_hepatobiliary_system2.49246342
10MP0003705_abnormal_hypodermis_morpholog2.36712163
11MP0004858_abnormal_nervous_system2.35437005
12MP0005085_abnormal_gallbladder_physiolo2.32644222
13MP0005409_darkened_coat_color2.32516122
14MP0005083_abnormal_biliary_tract2.28862956
15MP0010234_abnormal_vibrissa_follicle2.16639924
16MP0004087_abnormal_muscle_fiber2.15545670
17MP0010368_abnormal_lymphatic_system2.10158514
18MP0002972_abnormal_cardiac_muscle2.08285079
19MP0006138_congestive_heart_failure2.05749860
20MP0010630_abnormal_cardiac_muscle1.98475714
21MP0005360_urolithiasis1.98211051
22MP0003137_abnormal_impulse_conducting1.96516310
23MP0004130_abnormal_muscle_cell1.96397598
24MP0008775_abnormal_heart_ventricle1.95142977
25MP0000749_muscle_degeneration1.92699557
26MP0003646_muscle_fatigue1.86397804
27MP0005385_cardiovascular_system_phenoty1.84328005
28MP0001544_abnormal_cardiovascular_syste1.84328005
29MP0003122_maternal_imprinting1.83627663
30MP0005365_abnormal_bile_salt1.76744804
31MP0003123_paternal_imprinting1.74533245
32MP0000750_abnormal_muscle_regeneration1.73787671
33MP0005623_abnormal_meninges_morphology1.67962769
34MP0005620_abnormal_muscle_contractility1.64346008
35MP0004782_abnormal_surfactant_physiolog1.62207459
36MP0000537_abnormal_urethra_morphology1.55893922
37MP0001958_emphysema1.55832262
38MP0004085_abnormal_heartbeat1.53972613
39MP0005257_abnormal_intraocular_pressure1.53941438
40MP0009780_abnormal_chondrocyte_physiolo1.52038487
41MP0002269_muscular_atrophy1.49705683
42MP0002234_abnormal_pharynx_morphology1.48979467
43MP0003252_abnormal_bile_duct1.48325812
44MP0000566_synostosis1.47029916
45MP0003941_abnormal_skin_development1.42548895
46MP0000678_abnormal_parathyroid_gland1.39505602
47MP0004484_altered_response_of1.39244474
48MP0000747_muscle_weakness1.38200851
49MP0005167_abnormal_blood-brain_barrier1.35466118
50MP0002106_abnormal_muscle_physiology1.33457306
51MP0001666_abnormal_nutrient_absorption1.32373005
52MP0009384_cardiac_valve_regurgitation1.29926364
53MP0009840_abnormal_foam_cell1.29807748
54MP0003566_abnormal_cell_adhesion1.28735706
55MP0003950_abnormal_plasma_membrane1.26913916
56MP0003119_abnormal_digestive_system1.26453461
57MP0008875_abnormal_xenobiotic_pharmacok1.24838815
58MP0003828_pulmonary_edema1.22751355
59MP0004233_abnormal_muscle_weight1.22201540
60MP0002876_abnormal_thyroid_physiology1.19192032
61MP0000003_abnormal_adipose_tissue1.19123094
62MP0003115_abnormal_respiratory_system1.18630547
63MP0010329_abnormal_lipoprotein_level1.15864824
64MP0005187_abnormal_penis_morphology1.15419827
65MP0000759_abnormal_skeletal_muscle1.14769518
66MP0005076_abnormal_cell_differentiation1.12729434
67MP0009672_abnormal_birth_weight1.12725038
68MP0002697_abnormal_eye_size1.11836437
69MP0005666_abnormal_adipose_tissue1.11284332
70MP0000534_abnormal_ureter_morphology1.10651078
71MP0005451_abnormal_body_composition1.10334454
72MP0003567_abnormal_fetal_cardiomyocyte1.09673936
73MP0005369_muscle_phenotype1.07383093
74MP0001849_ear_inflammation1.07216825
75MP0003279_aneurysm1.06086662
76MP0002822_catalepsy1.03529566
77MP0004019_abnormal_vitamin_homeostasis1.02584682
78MP0005248_abnormal_Harderian_gland1.01919161
79MP0001730_embryonic_growth_arrest0.99596586
80MP0003315_abnormal_perineum_morphology0.99048555
81MP0004145_abnormal_muscle_electrophysio0.98596153
82MP0002796_impaired_skin_barrier0.96652695
83MP0002118_abnormal_lipid_homeostasis0.96042370
84MP0003300_gastrointestinal_ulcer0.95838623
85MP0003806_abnormal_nucleotide_metabolis0.95366254
86MP0002127_abnormal_cardiovascular_syste0.94817147
87MP0003385_abnormal_body_wall0.94192441
88MP0002098_abnormal_vibrissa_morphology0.94162167
89MP0005058_abnormal_lysosome_morphology0.93901757
90MP0010030_abnormal_orbit_morphology0.91251919
91MP0003329_amyloid_beta_deposits0.91115922
92MP0002909_abnormal_adrenal_gland0.89918825
93MP0010678_abnormal_skin_adnexa0.89488229
94MP0000266_abnormal_heart_morphology0.89142034
95MP0004270_analgesia0.88985137
96MP0003984_embryonic_growth_retardation0.88405633
97MP0001879_abnormal_lymphatic_vessel0.86719082
98MP0001661_extended_life_span0.86460371
99MP0004185_abnormal_adipocyte_glucose0.86170249
100MP0008004_abnormal_stomach_pH0.85586931
101MP0002128_abnormal_blood_circulation0.85565968
102MP0003937_abnormal_limbs/digits/tail_de0.84405772
103MP0002088_abnormal_embryonic_growth/wei0.83699331
104MP0000462_abnormal_digestive_system0.82897342
105MP0002653_abnormal_ependyma_morphology0.82782026
106MP0000767_abnormal_smooth_muscle0.82141111
107MP0000467_abnormal_esophagus_morphology0.81831570
108MP0005375_adipose_tissue_phenotype0.81807731
109MP0003868_abnormal_feces_composition0.81053886
110MP0003183_abnormal_peptide_metabolism0.80958903
111MP0002896_abnormal_bone_mineralization0.80421569
112MP0005275_abnormal_skin_tensile0.80404103
113MP0000579_abnormal_nail_morphology0.80355288
114MP0000733_abnormal_muscle_development0.80241243
115MP0002086_abnormal_extraembryonic_tissu0.79573633
116MP0000477_abnormal_intestine_morphology0.79101069
117MP0003221_abnormal_cardiomyocyte_apopto0.79046912
118MP0003283_abnormal_digestive_organ0.78883314
119MP0000681_abnormal_thyroid_gland0.76350308
120MP0002138_abnormal_hepatobiliary_system0.76254975
121MP0005670_abnormal_white_adipose0.76247332
122MP0002249_abnormal_larynx_morphology0.76221491
123MP0005165_increased_susceptibility_to0.74452996
124MP0003453_abnormal_keratinocyte_physiol0.74262687
125MP0001672_abnormal_embryogenesis/_devel0.74152203
126MP0005380_embryogenesis_phenotype0.74152203
127MP0003935_abnormal_craniofacial_develop0.72756415
128MP0008438_abnormal_cutaneous_collagen0.72336450
129MP0010352_gastrointestinal_tract_polyps0.71517690
130MP0001614_abnormal_blood_vessel0.71128735
131MP0002295_abnormal_pulmonary_circulatio0.70642328
132MP0009379_abnormal_foot_pigmentation0.70373115
133MP0005501_abnormal_skin_physiology0.69985660
134MP0000538_abnormal_urinary_bladder0.69813115
135MP0009053_abnormal_anal_canal0.68909236
136MP0000762_abnormal_tongue_morphology0.68770692
137MP0003634_abnormal_glial_cell0.68730893
138MP0002111_abnormal_tail_morphology0.68060105
139MP0005319_abnormal_enzyme/_coenzyme0.67787871
140MP0003045_fibrosis0.67417908
141MP0002108_abnormal_muscle_morphology0.67116698
142MP0002925_abnormal_cardiovascular_devel0.66606066
143MP0003942_abnormal_urinary_system0.64652176
144MP0002089_abnormal_postnatal_growth/wei0.64296659

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.81446759
2Right ventricular cardiomyopathy (HP:0011663)5.48830685
3Ventricular tachycardia (HP:0004756)4.93699497
4Syncope (HP:0001279)3.92271953
5Hyporeflexia of lower limbs (HP:0002600)3.78749278
6Atrial fibrillation (HP:0005110)3.71870622
7Ventricular fibrillation (HP:0001663)3.57732563
8Primary atrial arrhythmia (HP:0001692)3.52427380
9Muscle fiber splitting (HP:0003555)3.46462108
10Palpitations (HP:0001962)3.46163515
11Abnormality of the left ventricular outflow tract (HP:0011103)3.41494401
12Subaortic stenosis (HP:0001682)3.41494401
13Lipoatrophy (HP:0100578)3.39644728
14Supraventricular arrhythmia (HP:0005115)3.39592892
15Supraventricular tachycardia (HP:0004755)3.35402617
16Bundle branch block (HP:0011710)3.35158889
17Ventricular arrhythmia (HP:0004308)3.33988183
18Exercise-induced muscle cramps (HP:0003710)3.30547138
19Prolonged QT interval (HP:0001657)3.21102941
20Calf muscle hypertrophy (HP:0008981)3.20197388
21Exercise-induced myalgia (HP:0003738)3.19671028
22Abnormality of the calf musculature (HP:0001430)3.18273973
23Broad metatarsal (HP:0001783)3.05753187
24Hemorrhage of the eye (HP:0011885)3.02910773
25Deep venous thrombosis (HP:0002625)2.97903794
26Myoglobinuria (HP:0002913)2.95575418
27Asymmetric septal hypertrophy (HP:0001670)2.93710855
28Dilated cardiomyopathy (HP:0001644)2.84318227
29Difficulty running (HP:0009046)2.83552607
30Insidious onset (HP:0003587)2.81341766
31Termporal pattern (HP:0011008)2.81341766
32Abnormality of glutamine family amino acid metabolism (HP:0010902)2.81162496
33Atrioventricular block (HP:0001678)2.80819393
34Flat acetabular roof (HP:0003180)2.78812249
35Ulnar claw (HP:0001178)2.75338367
36Muscle hypertrophy of the lower extremities (HP:0008968)2.74905666
37Heart block (HP:0012722)2.70085742
38Lymphangioma (HP:0100764)2.69262533
39Protrusio acetabuli (HP:0003179)2.68817256
40EMG: myopathic abnormalities (HP:0003458)2.65980748
41Increased connective tissue (HP:0009025)2.56810072
42Partial duplication of thumb phalanx (HP:0009944)2.55918212
43Abnormal atrioventricular conduction (HP:0005150)2.52704367
44Abnormality of carpal bone ossification (HP:0006257)2.45213898
45Complement deficiency (HP:0004431)2.38280136
46Visceral angiomatosis (HP:0100761)2.35272113
47Aplasia of the phalanges of the hand (HP:0009802)2.35112519
48Aplasia involving bones of the extremities (HP:0009825)2.35112519
49Aplasia involving bones of the upper limbs (HP:0009823)2.35112519
50Mildly elevated creatine phosphokinase (HP:0008180)2.32692671
51Neonatal short-limb short stature (HP:0008921)2.31977336
52Myotonia (HP:0002486)2.31345268
53Ulnar bowing (HP:0003031)2.29916762
54Gout (HP:0001997)2.26081347
55Difficulty climbing stairs (HP:0003551)2.25648392
56Cerebral aneurysm (HP:0004944)2.23054187
57Ketoacidosis (HP:0001993)2.22184612
58Esophageal varix (HP:0002040)2.20631909
59Vitreoretinal degeneration (HP:0000655)2.17139821
60Abnormal EKG (HP:0003115)2.16000855
61Abnormal ventriculo-arterial connection (HP:0011563)2.15775903
62Transposition of the great arteries (HP:0001669)2.15775903
63Abnormal connection of the cardiac segments (HP:0011545)2.15775903
64Sudden cardiac death (HP:0001645)2.14972554
65Hypoglycemic coma (HP:0001325)2.13566771
66Abnormality of the aortic arch (HP:0012303)2.13385570
67Polycythemia (HP:0001901)2.12985686
68Hypercholesterolemia (HP:0003124)2.12103645
69Abnormality of complement system (HP:0005339)2.12044710
70Interstitial pulmonary disease (HP:0006530)2.11495273
71Hemangiomatosis (HP:0007461)2.11220884
72Asymmetry of the thorax (HP:0001555)2.08075976
73Partial duplication of the phalanx of hand (HP:0009999)2.07902650
74Choanal stenosis (HP:0000452)2.07355103
75Abnormal tarsal ossification (HP:0008369)2.07268963
76Abnormality of the foot musculature (HP:0001436)2.07229868
77Aneurysm (HP:0002617)2.06386425
78Abnormal ossification of hand bones (HP:0005921)2.05966522
79Delayed epiphyseal ossification (HP:0002663)2.05278874
80Premature rupture of membranes (HP:0001788)2.03733223
81Ketosis (HP:0001946)2.03124538
82Cortical dysplasia (HP:0002539)2.02396406
83Limb-girdle muscle atrophy (HP:0003797)2.00975235
84Hypobetalipoproteinemia (HP:0003563)2.00772224
85Intrahepatic cholestasis (HP:0001406)1.99830243
86Small epiphyses (HP:0010585)1.98955226
87Increased variability in muscle fiber diameter (HP:0003557)1.97579358
88Abnormality of proline metabolism (HP:0010907)1.96978045
89Hydroxyprolinuria (HP:0003080)1.96978045
90Rhabdomyolysis (HP:0003201)1.95234854
91Foot dorsiflexor weakness (HP:0009027)1.93936854
92Abnormality of the distal phalanx of the thumb (HP:0009617)1.93682138
93Thin bony cortex (HP:0002753)1.92591592
94Hamartoma of the eye (HP:0010568)1.92387032
95Hyperammonemia (HP:0001987)1.91717127
96Upper limb amyotrophy (HP:0009129)1.90858300
97Distal upper limb amyotrophy (HP:0007149)1.90858300
98Periauricular skin pits (HP:0100277)1.89817378
99Preauricular pit (HP:0004467)1.89817378
100Pterygium (HP:0001059)1.89600233
101Shallow orbits (HP:0000586)1.88930560
102Xanthomatosis (HP:0000991)1.88860208
103Congenital malformation of the right heart (HP:0011723)1.87817544
104Double outlet right ventricle (HP:0001719)1.87817544
105Back pain (HP:0003418)1.87493642
106Long toe (HP:0010511)1.87296242
107Hepatoblastoma (HP:0002884)1.84580720
108Abdominal distention (HP:0003270)1.83973711
109Palmoplantar keratoderma (HP:0000982)1.83773766
110Atrophic scars (HP:0001075)1.82550022
111Hammertoe (HP:0001765)1.82238017
112Neonatal death (HP:0003811)1.81751681
113Prolonged partial thromboplastin time (HP:0003645)1.81449627
114Pili torti (HP:0003777)1.79837971
115Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79442107
116Abnormal hand bone ossification (HP:0010660)1.79259607
117Pheochromocytoma (HP:0002666)1.78706804
118Mesangial abnormality (HP:0001966)1.78332112
119Rectal prolapse (HP:0002035)1.78270742
120Cavernous hemangioma (HP:0001048)1.78121432
121Germ cell neoplasia (HP:0100728)1.77876541
122Wide cranial sutures (HP:0010537)1.77761736
123Late onset (HP:0003584)1.77729231
124Action tremor (HP:0002345)1.77065401
125Truncus arteriosus (HP:0001660)1.76900487
126Hypoplastic left heart (HP:0004383)1.76878154
127Segmental peripheral demyelination/remyelination (HP:0003481)1.76740128
128Turricephaly (HP:0000262)1.75395859
129Skin nodule (HP:0200036)1.74833522
130Focal segmental glomerulosclerosis (HP:0000097)1.73861365
131Conjunctival hamartoma (HP:0100780)1.73690180
132Abnormality of monocarboxylic acid metabolism (HP:0010996)1.73499578
133Vertebral arch anomaly (HP:0008438)1.72882831
134Abnormality of the Achilles tendon (HP:0005109)1.72091514
135Cupped ribs (HP:0000887)1.71331297
136Bronchomalacia (HP:0002780)1.71125649
137Abnormality of fatty-acid metabolism (HP:0004359)1.70860479
138Arterial tortuosity (HP:0005116)1.70707034
139Abnormality of the vocal cords (HP:0008777)1.70256466
140Impaired proprioception (HP:0010831)1.69595042
141Vaginal fistula (HP:0004320)1.68951007
142Type 1 muscle fiber predominance (HP:0003803)1.67414700
143Patent foramen ovale (HP:0001655)1.67152570
144Hyperacusis (HP:0010780)1.66764469
145Scapular winging (HP:0003691)1.66620800
146Skin pits (HP:0100276)1.64439255
147Megalencephaly (HP:0001355)1.63574031
148Centrally nucleated skeletal muscle fibers (HP:0003687)1.63344063
149Abnormality of the vitreous humor (HP:0004327)1.63136218
150Distal lower limb amyotrophy (HP:0008944)1.62557984
151Respiratory distress (HP:0002098)1.62474189
152Osteomalacia (HP:0002749)1.62124155
153Coronal craniosynostosis (HP:0004440)1.61856386
154Broad palm (HP:0001169)1.60638864
155Abnormality of skeletal muscle fiber size (HP:0012084)1.60608752
156Advanced eruption of teeth (HP:0006288)1.60252920
157Vertebral clefting (HP:0008428)1.59961720
158Hypoplastic ischia (HP:0003175)1.59454577
159Ragged-red muscle fibers (HP:0003200)1.57807218
160Large for gestational age (HP:0001520)1.56461216
161Hyperglycinuria (HP:0003108)1.56140628
162Enlarged penis (HP:0000040)1.54751537
163Rapidly progressive (HP:0003678)1.54687828
164Ankle contracture (HP:0006466)1.54623601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.97539282
2LMTK23.68910784
3PKN23.36839596
4TTN2.75731873
5PHKG12.53511739
6PHKG22.53511739
7SMG12.42461357
8RIPK12.42192723
9SIK12.41319134
10TIE12.33115468
11EPHB22.06354997
12DMPK1.99784356
13MYLK1.93838265
14PDGFRA1.91118313
15EPHB11.80609831
16PTK61.79550780
17CDK121.77029874
18BCKDK1.74501928
19FER1.69179245
20STK241.63990919
21ICK1.62137104
22FGFR41.55200832
23LATS11.53333988
24NTRK11.51605474
25PAK31.49160887
26ERN11.45480774
27ILK1.45246418
28ERBB21.43780312
29NEK11.39191617
30PDK31.34501538
31PDK41.34501538
32FGFR21.31839168
33EPHA21.31519737
34PIK3CA1.30095915
35MAP3K101.18702376
36MAP3K71.16609914
37RET1.15987612
38PRKD11.13504420
39TYRO31.13291305
40ROCK11.12036221
41PRKD31.10716418
42KSR21.10650033
43DDR21.06870747
44LATS21.05235641
45LRRK21.04648338
46PAK41.01826058
47EPHA31.00988068
48PTK21.00350646
49EEF2K0.98536062
50OBSCN0.96551357
51PDGFRB0.94608843
52WNK40.94523672
53TAOK20.93970123
54TNIK0.91003734
55ROCK20.88761767
56DYRK1B0.88667302
57FGFR30.87853018
58STK390.86518176
59LIMK10.84643306
60ERBB40.82844048
61PAK60.82479627
62CDC42BPA0.82066065
63MATK0.81919811
64TGFBR20.79711654
65MET0.78440043
66MTOR0.75921558
67FGFR10.75493070
68RPS6KB20.71814819
69KSR10.71563690
70AKT30.67916802
71MAP2K20.65651936
72MAP3K20.65176845
73BMX0.64865613
74MAP2K10.64651059
75MARK10.62410109
76TESK10.61341444
77CAMK1D0.60529408
78MAPKAPK30.58659442
79PRKAA10.58264324
80PRPF4B0.58162588
81CAMK1G0.57975709
82PRKG20.57687130
83KDR0.57681504
84PAK20.56604888
85PDK20.55413926
86GSK3A0.54560316
87CASK0.54029739
88MST1R0.53839874
89DAPK20.53774667
90WNK10.52287739
91ARAF0.52240168
92DAPK30.52096073
93CAMK2D0.51887194
94RPS6KA20.50599533
95MAP3K90.49165872
96PRKAA20.48950651
97PRKCZ0.47577894
98RPS6KC10.47102670
99RPS6KL10.47102670
100PTK2B0.46853495
101MAP3K10.46286810
102NEK20.45416861
103STK380.42757744
104UHMK10.42749898
105AKT20.41523155
106STK38L0.39235682
107CDK60.37985857
108INSRR0.37305248
109PDPK10.36774771
110SRC0.36731229
111MAP3K80.36623138
112MARK20.36506104
113IRAK30.36119734
114TGFBR10.36068599
115NTRK20.35826163
116PRKCE0.35247758
117CDK70.35041759
118BRAF0.34088724
119TAOK10.31325384
120SIK20.29639086
121MAP2K60.29358276
122CSNK1E0.27679418
123RPS6KA60.26241786
124RPS6KA10.26034629

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.02751405
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.01238883
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.97900942
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.76569287
5Fatty acid degradation_Homo sapiens_hsa000712.64860192
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.42809687
7Fatty acid metabolism_Homo sapiens_hsa012122.25313428
8Dilated cardiomyopathy_Homo sapiens_hsa054142.17078395
9Nitrogen metabolism_Homo sapiens_hsa009102.13320142
10Propanoate metabolism_Homo sapiens_hsa006402.08756166
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.08255802
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.99911890
13Arginine biosynthesis_Homo sapiens_hsa002201.92038110
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.91263123
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90876188
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.79193638
17Fructose and mannose metabolism_Homo sapiens_hsa000511.77596487
18Butanoate metabolism_Homo sapiens_hsa006501.74902855
19Vitamin digestion and absorption_Homo sapiens_hsa049771.74484615
20Galactose metabolism_Homo sapiens_hsa000521.67629002
21Tryptophan metabolism_Homo sapiens_hsa003801.65673701
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.65597541
23PPAR signaling pathway_Homo sapiens_hsa033201.61668921
24Cardiac muscle contraction_Homo sapiens_hsa042601.52314995
25Carbon metabolism_Homo sapiens_hsa012001.49984636
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49530277
27Bile secretion_Homo sapiens_hsa049761.46804475
28Thyroid hormone synthesis_Homo sapiens_hsa049181.46768270
29Pyruvate metabolism_Homo sapiens_hsa006201.31951562
30Renin-angiotensin system_Homo sapiens_hsa046141.30822986
31ECM-receptor interaction_Homo sapiens_hsa045121.25692210
32Viral myocarditis_Homo sapiens_hsa054161.21265599
33Fatty acid biosynthesis_Homo sapiens_hsa000611.19875666
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19585385
35Fatty acid elongation_Homo sapiens_hsa000621.17887642
36Tight junction_Homo sapiens_hsa045301.16370358
37Focal adhesion_Homo sapiens_hsa045101.13056786
38Adherens junction_Homo sapiens_hsa045201.12630825
39Fat digestion and absorption_Homo sapiens_hsa049751.11787092
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08906223
41Retinol metabolism_Homo sapiens_hsa008301.08059202
42Sulfur relay system_Homo sapiens_hsa041221.00298381
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99079723
44Lysine degradation_Homo sapiens_hsa003100.95208530
45Insulin resistance_Homo sapiens_hsa049310.94830456
46beta-Alanine metabolism_Homo sapiens_hsa004100.93333820
47Dorso-ventral axis formation_Homo sapiens_hsa043200.91256244
48Biosynthesis of amino acids_Homo sapiens_hsa012300.90581116
49Pentose phosphate pathway_Homo sapiens_hsa000300.89576460
50Other glycan degradation_Homo sapiens_hsa005110.88321207
51Sulfur metabolism_Homo sapiens_hsa009200.88309027
52Starch and sucrose metabolism_Homo sapiens_hsa005000.86417805
53Bladder cancer_Homo sapiens_hsa052190.84706295
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.82828643
55Insulin signaling pathway_Homo sapiens_hsa049100.82499623
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81991737
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.80966237
58Phenylalanine metabolism_Homo sapiens_hsa003600.80963279
59Amoebiasis_Homo sapiens_hsa051460.80733856
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.79135422
61Arginine and proline metabolism_Homo sapiens_hsa003300.78900804
62AMPK signaling pathway_Homo sapiens_hsa041520.78148547
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77072112
64Steroid biosynthesis_Homo sapiens_hsa001000.76653979
65Endometrial cancer_Homo sapiens_hsa052130.75318130
66Histidine metabolism_Homo sapiens_hsa003400.74782874
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.74491706
68Hippo signaling pathway_Homo sapiens_hsa043900.74324540
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73927041
70Complement and coagulation cascades_Homo sapiens_hsa046100.73505865
71Notch signaling pathway_Homo sapiens_hsa043300.72849785
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.72075298
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72008735
74Caffeine metabolism_Homo sapiens_hsa002320.71808630
75Peroxisome_Homo sapiens_hsa041460.70092641
76Axon guidance_Homo sapiens_hsa043600.67997337
77Basal cell carcinoma_Homo sapiens_hsa052170.67105822
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66331691
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65984254
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65538071
81Proteoglycans in cancer_Homo sapiens_hsa052050.65510494
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64397281
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63784210
84Prion diseases_Homo sapiens_hsa050200.63543436
85Glucagon signaling pathway_Homo sapiens_hsa049220.62899461
86Small cell lung cancer_Homo sapiens_hsa052220.62232029
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61084423
88Gastric acid secretion_Homo sapiens_hsa049710.61048387
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60481685
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57809012
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57564567
92Protein digestion and absorption_Homo sapiens_hsa049740.57133520
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56744104
94Renal cell carcinoma_Homo sapiens_hsa052110.54218330
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53083056
96Gap junction_Homo sapiens_hsa045400.51903376
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50628125
98Tyrosine metabolism_Homo sapiens_hsa003500.49975214
99Chemical carcinogenesis_Homo sapiens_hsa052040.49426807
100Glycerolipid metabolism_Homo sapiens_hsa005610.47817422
101ABC transporters_Homo sapiens_hsa020100.46117373
102Estrogen signaling pathway_Homo sapiens_hsa049150.45252407
103Vitamin B6 metabolism_Homo sapiens_hsa007500.44849728
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.44086069
105Melanogenesis_Homo sapiens_hsa049160.43492752
106VEGF signaling pathway_Homo sapiens_hsa043700.43488930
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42737203
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42486623
109Glioma_Homo sapiens_hsa052140.41881811
110N-Glycan biosynthesis_Homo sapiens_hsa005100.41015512
111Hedgehog signaling pathway_Homo sapiens_hsa043400.40551249
112Cocaine addiction_Homo sapiens_hsa050300.39436058
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39319374
114Renin secretion_Homo sapiens_hsa049240.38971547
115Thyroid cancer_Homo sapiens_hsa052160.38624503
116Ovarian steroidogenesis_Homo sapiens_hsa049130.38600786
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.38516830
118Chronic myeloid leukemia_Homo sapiens_hsa052200.38294310
119Pancreatic secretion_Homo sapiens_hsa049720.38099158
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37212292
121Type II diabetes mellitus_Homo sapiens_hsa049300.36154087
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35587303
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35483343
124Mineral absorption_Homo sapiens_hsa049780.35238690

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