MMP17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)8.04129698
2melanin metabolic process (GO:0006582)7.43564019
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.58195500
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.39383801
5secondary metabolite biosynthetic process (GO:0044550)6.31335260
6synaptic vesicle maturation (GO:0016188)6.29452687
7locomotory exploration behavior (GO:0035641)6.16947807
8vocalization behavior (GO:0071625)5.94200902
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.83535164
10synaptic vesicle exocytosis (GO:0016079)5.60283803
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.52497919
12glutamate secretion (GO:0014047)5.49287033
13regulation of glutamate receptor signaling pathway (GO:1900449)5.47840239
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.47322079
15ionotropic glutamate receptor signaling pathway (GO:0035235)5.12547122
16protein localization to synapse (GO:0035418)5.10580148
17regulation of synaptic vesicle exocytosis (GO:2000300)5.06496258
18regulation of long-term neuronal synaptic plasticity (GO:0048169)5.02746468
19regulation of neuronal synaptic plasticity (GO:0048168)5.00433715
20exploration behavior (GO:0035640)4.77352309
21neuronal action potential propagation (GO:0019227)4.76876091
22regulation of synapse structural plasticity (GO:0051823)4.63645471
23regulation of synaptic vesicle transport (GO:1902803)4.59492379
24synaptic transmission, glutamatergic (GO:0035249)4.58029885
25cell migration in hindbrain (GO:0021535)4.54417355
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.53080789
27neurotransmitter-gated ion channel clustering (GO:0072578)4.51383408
28neurotransmitter secretion (GO:0007269)4.49815245
29glutamate receptor signaling pathway (GO:0007215)4.47158075
30dendritic spine morphogenesis (GO:0060997)4.46962781
31neuron cell-cell adhesion (GO:0007158)4.36995682
32layer formation in cerebral cortex (GO:0021819)4.32365432
33regulation of excitatory postsynaptic membrane potential (GO:0060079)4.29928109
34long-term memory (GO:0007616)4.27968112
35positive regulation of membrane potential (GO:0045838)4.24881647
36neuron-neuron synaptic transmission (GO:0007270)4.24553414
37regulation of dendritic spine morphogenesis (GO:0061001)4.18520684
38regulation of postsynaptic membrane potential (GO:0060078)4.03596182
39regulation of synaptic plasticity (GO:0048167)4.03482132
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.98233034
41positive regulation of synapse maturation (GO:0090129)3.86576555
42gamma-aminobutyric acid transport (GO:0015812)3.81617068
43G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.79220390
44proline transport (GO:0015824)3.72136536
45long-term synaptic potentiation (GO:0060291)3.71908867
46positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.71062826
47semaphorin-plexin signaling pathway (GO:0071526)3.68298306
48neuromuscular process controlling balance (GO:0050885)3.67249781
49positive regulation of neurotransmitter secretion (GO:0001956)3.64813598
50transmission of nerve impulse (GO:0019226)3.58694682
51regulation of synaptic transmission, glutamatergic (GO:0051966)3.58192692
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.57979495
53cell-cell junction maintenance (GO:0045217)3.57385042
54regulation of neurotransmitter secretion (GO:0046928)3.55553306
55cellular potassium ion homeostasis (GO:0030007)3.55084308
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.54932440
57neurotransmitter transport (GO:0006836)3.53560152
58cytoskeletal anchoring at plasma membrane (GO:0007016)3.52151602
59regulation of dendritic spine development (GO:0060998)3.52058978
60negative regulation of synaptic transmission, GABAergic (GO:0032229)3.51916838
61dendritic spine organization (GO:0097061)3.51130724
62positive regulation of dendritic spine morphogenesis (GO:0061003)3.50546660
63activation of protein kinase A activity (GO:0034199)3.48573780
64neuron recognition (GO:0008038)3.48154342
65gamma-aminobutyric acid signaling pathway (GO:0007214)3.46937826
66positive regulation of neurotransmitter transport (GO:0051590)3.46076908
67positive regulation of dendritic spine development (GO:0060999)3.45639899
68melanocyte differentiation (GO:0030318)3.44396755
69synaptic vesicle endocytosis (GO:0048488)3.41968623
70postsynaptic membrane organization (GO:0001941)3.40714635
71behavioral fear response (GO:0001662)3.39958046
72behavioral defense response (GO:0002209)3.39958046
73auditory behavior (GO:0031223)3.39212721
74regulation of vesicle fusion (GO:0031338)3.38668687
75regulation of ARF protein signal transduction (GO:0032012)3.35711388
76membrane depolarization (GO:0051899)3.33233760
77regulation of neurotransmitter levels (GO:0001505)3.32058942
78negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.31323427
79learning (GO:0007612)3.30166492
80chondroitin sulfate catabolic process (GO:0030207)3.29170387
81regulation of neurotransmitter transport (GO:0051588)3.28343202
82pigment cell differentiation (GO:0050931)3.24749901
83response to auditory stimulus (GO:0010996)3.23395867
84protein retention in ER lumen (GO:0006621)3.23382914
85neuronal ion channel clustering (GO:0045161)3.22190299
86axonal fasciculation (GO:0007413)3.22108271
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.21291309
88sodium ion export (GO:0071436)3.20787360
89prepulse inhibition (GO:0060134)3.20778098
90positive regulation of synaptic transmission (GO:0050806)3.20345471
91response to histamine (GO:0034776)3.20210054
92amino acid import (GO:0043090)3.19620536
93regulation of synaptic transmission (GO:0050804)3.18560974
94cerebellar Purkinje cell layer development (GO:0021680)3.17611201
95neuromuscular process controlling posture (GO:0050884)3.16814404
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16189205
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.15818765
98positive regulation of fibroblast migration (GO:0010763)3.15140602
99cerebellar Purkinje cell differentiation (GO:0021702)3.15056564
100cerebellar granule cell differentiation (GO:0021707)3.13610844
101membrane hyperpolarization (GO:0060081)3.13151798
102fear response (GO:0042596)3.12883514
103neuromuscular process (GO:0050905)3.09845010
104establishment of mitochondrion localization (GO:0051654)3.09555596
105innervation (GO:0060384)3.07599955
106intraspecies interaction between organisms (GO:0051703)3.07515963
107social behavior (GO:0035176)3.07515963
108chemosensory behavior (GO:0007635)3.06221016
109regulation of glutamate secretion (GO:0014048)3.05958084
110L-amino acid import (GO:0043092)3.05878928
111presynaptic membrane assembly (GO:0097105)3.05608080
112synaptic transmission (GO:0007268)3.05094450
113regulation of synapse maturation (GO:0090128)3.04302861
114cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.03880479
115dermatan sulfate metabolic process (GO:0030205)3.03485886
116membrane depolarization during action potential (GO:0086010)3.02224439
117regulation of female receptivity (GO:0045924)3.01986331
118long term synaptic depression (GO:0060292)3.01760380
119dendrite morphogenesis (GO:0048813)3.01211321
120maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.98513581
121mating behavior (GO:0007617)2.96016627
122protein localization to endosome (GO:0036010)2.91640035
123mitochondrion transport along microtubule (GO:0047497)2.84459982
124establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.84459982
125dopamine receptor signaling pathway (GO:0007212)2.83563790
126positive regulation of protein dephosphorylation (GO:0035307)2.81556856
127axon regeneration (GO:0031103)2.81362207
128regulation of ARF GTPase activity (GO:0032312)2.77702745
129response to dietary excess (GO:0002021)2.74469018
130dermatan sulfate biosynthetic process (GO:0030208)2.72223227
131basement membrane organization (GO:0071711)2.70546197
132neuron projection regeneration (GO:0031102)2.69959258
133negative regulation of microtubule polymerization (GO:0031115)2.69958565
134cell junction maintenance (GO:0034331)2.68479570
135regulation of mammary gland epithelial cell proliferation (GO:0033599)2.64128049
136mannose metabolic process (GO:0006013)2.62693376
137regulation of early endosome to late endosome transport (GO:2000641)2.61515605
138regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.53827711
139cellular response to catecholamine stimulus (GO:0071870)2.53042338
140cellular response to monoamine stimulus (GO:0071868)2.53042338
141adherens junction assembly (GO:0034333)2.52736894
142barbed-end actin filament capping (GO:0051016)2.52520146
143axon extension (GO:0048675)2.51101607
144cell communication by electrical coupling (GO:0010644)2.50495075
145positive regulation of axon extension (GO:0045773)2.49508234
146protein targeting to plasma membrane (GO:0072661)2.49149013
147neuron projection extension (GO:1990138)2.48698539
148planar cell polarity pathway involved in neural tube closure (GO:0090179)2.46725815
149adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.44682614
150negative regulation of dendrite morphogenesis (GO:0050774)2.44363351
151cellular component maintenance (GO:0043954)2.43421527
152enteric nervous system development (GO:0048484)2.39590327

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.45115430
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.71083530
3GBX2_23144817_ChIP-Seq_PC3_Human3.47458775
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.23739288
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23730729
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13764635
7LXR_22292898_ChIP-Seq_THP-1_Human2.99624493
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.96345045
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.86804427
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.86804427
11REST_21632747_ChIP-Seq_MESCs_Mouse2.79318143
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77915094
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.73447456
14* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.73088200
15DROSHA_22980978_ChIP-Seq_HELA_Human2.71129578
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57443247
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.56696520
18* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56433538
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55261583
20* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51325637
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.41585588
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.34101820
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33570855
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.30116498
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.28555518
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26173106
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.25720282
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.24779543
29RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22004298
30KDM2B_26808549_Chip-Seq_DND41_Human2.20959987
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.12630937
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11236477
33ELK3_25401928_ChIP-Seq_HUVEC_Human2.10831012
34* VDR_21846776_ChIP-Seq_THP-1_Human2.08465691
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.07068690
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04083073
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92041622
38AR_21572438_ChIP-Seq_LNCaP_Human1.91794027
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81588983
40* RACK7_27058665_Chip-Seq_MCF-7_Human1.77676894
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.71980862
42MYC_22102868_ChIP-Seq_BL_Human1.70658282
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.70307769
44TCF7_22412390_ChIP-Seq_EML_Mouse1.69239554
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.68639865
46* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.67240617
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66810684
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66175683
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65647511
50* CTCF_27219007_Chip-Seq_Bcells_Human1.61185624
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59925781
52TET1_21490601_ChIP-Seq_MESCs_Mouse1.59179625
53* KDM2B_26808549_Chip-Seq_JURKAT_Human1.58013593
54SMC4_20622854_ChIP-Seq_HELA_Human1.57399009
55P68_20966046_ChIP-Seq_HELA_Human1.56852691
56SMAD4_21799915_ChIP-Seq_A2780_Human1.56423374
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55511895
58* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53556979
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49615501
60* SA1_27219007_Chip-Seq_ERYTHROID_Human1.46559444
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45765881
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44894910
63* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43509570
64TAF15_26573619_Chip-Seq_HEK293_Human1.42964960
65CREB1_26743006_Chip-Seq_LNCaP_Human1.41245474
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40011941
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.39031297
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38104760
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.37996837
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37084895
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33962126
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33328350
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32593429
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.32046361
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.32014768
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31015996
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30013877
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29737258
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28711081
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.26778787
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.26436039
82P300_19829295_ChIP-Seq_ESCs_Human1.25861461
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25647713
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25279178
85MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25072255
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24683743
87SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.23379655
88AR_19668381_ChIP-Seq_PC3_Human1.22274577
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20104359
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20034154
91AR_25329375_ChIP-Seq_VCAP_Human1.19316126
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.17946383
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17695419
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16890541
95TP63_17297297_ChIP-ChIP_HaCaT_Human1.15884238
96STAT3_23295773_ChIP-Seq_U87_Human1.15266478
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15151682
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14214437
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.12780692
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12299516
101* KDM2B_26808549_Chip-Seq_K562_Human1.11669257
102TP53_22127205_ChIP-Seq_IMR90_Human1.11649936
103CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11582612
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10155064
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09993413
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09967176
107* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09463363
108* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08335567
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08145100
110* MITF_21258399_ChIP-Seq_MELANOMA_Human1.08090168
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.07676617
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07544000
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07335506
114OCT4_19829295_ChIP-Seq_ESCs_Human1.06831818
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06763025
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04521408
117TCF4_23295773_ChIP-Seq_U87_Human1.03930486
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03698907
119TP53_20018659_ChIP-ChIP_R1E_Mouse1.03598711
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03381948
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02814629
122YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02530071
123TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02462927
124SMAD3_21741376_ChIP-Seq_HESCs_Human1.02404025
125VDR_24763502_ChIP-Seq_THP-1_Human1.01149653
126TP53_23651856_ChIP-Seq_MEFs_Mouse1.01143121
127PIAS1_25552417_ChIP-Seq_VCAP_Human0.99424756
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99063830
129* ZNF274_21170338_ChIP-Seq_K562_Hela0.98409622
130BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98098159
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.98032393
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97425378
133TP53_16413492_ChIP-PET_HCT116_Human0.97289599
134RNF2_27304074_Chip-Seq_NSC_Mouse0.96398514
135CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96284232
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96192960
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95842637
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95553402
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.95018822
140JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94501420
141AHR_22903824_ChIP-Seq_MCF-7_Human0.94174047
142SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93883462
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.92310507
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91569956
145RUNX2_22187159_ChIP-Seq_PCA_Human0.91352679
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.89780185
147TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89373917
148AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88748549
149RXR_22108803_ChIP-Seq_LS180_Human0.88368436
150CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87373093
151CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87003511
152* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86644025
153JUN_21703547_ChIP-Seq_K562_Human0.86042455
154POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86012317
155TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86012317
156FUS_26573619_Chip-Seq_HEK293_Human0.85845235
157* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83505529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.60770512
2MP0005171_absent_coat_pigmentation7.17557597
3MP0003880_abnormal_central_pattern4.94915523
4MP0003635_abnormal_synaptic_transmissio4.49377923
5MP0004270_analgesia3.80138790
6MP0009745_abnormal_behavioral_response3.71455581
7MP0002822_catalepsy3.65752988
8MP0002063_abnormal_learning/memory/cond3.65286980
9MP0000372_irregular_coat_pigmentation3.46051893
10MP0003136_yellow_coat_color3.35094752
11MP0002064_seizures3.32790539
12MP0005257_abnormal_intraocular_pressure3.24188600
13MP0004381_abnormal_hair_follicle3.13533809
14MP0009046_muscle_twitch3.06160439
15MP0001968_abnormal_touch/_nociception3.00728713
16MP0002572_abnormal_emotion/affect_behav2.96522117
17MP0005075_abnormal_melanosome_morpholog2.82103243
18MP0003172_abnormal_lysosome_physiology2.79190221
19MP0001486_abnormal_startle_reflex2.69693594
20MP0002272_abnormal_nervous_system2.62073307
21MP0002734_abnormal_mechanical_nocicepti2.55285411
22MP0003705_abnormal_hypodermis_morpholog2.54669898
23MP0005423_abnormal_somatic_nervous2.52805292
24MP0005058_abnormal_lysosome_morphology2.49683570
25MP0000015_abnormal_ear_pigmentation2.45155268
26MP0008438_abnormal_cutaneous_collagen2.43039397
27MP0001501_abnormal_sleep_pattern2.37022165
28MP0002736_abnormal_nociception_after2.31023752
29MP0008260_abnormal_autophagy2.27978527
30MP0005408_hypopigmentation2.25400516
31MP0002735_abnormal_chemical_nociception2.09292950
32MP0001440_abnormal_grooming_behavior2.08260271
33MP0002877_abnormal_melanocyte_morpholog2.00512651
34MP0002733_abnormal_thermal_nociception1.91969603
35MP0008569_lethality_at_weaning1.90624876
36MP0009780_abnormal_chondrocyte_physiolo1.89989219
37MP0001970_abnormal_pain_threshold1.88624708
38MP0002067_abnormal_sensory_capabilities1.84420377
39MP0004811_abnormal_neuron_physiology1.82573995
40MP0002557_abnormal_social/conspecific_i1.77518137
41MP0004858_abnormal_nervous_system1.76901667
42MP0000371_diluted_coat_color1.74139185
43MP0000778_abnormal_nervous_system1.70525750
44MP0002184_abnormal_innervation1.70319836
45MP0003879_abnormal_hair_cell1.67500061
46MP0005386_behavior/neurological_phenoty1.65800044
47MP0004924_abnormal_behavior1.65800044
48MP0005646_abnormal_pituitary_gland1.64024292
49MP0002909_abnormal_adrenal_gland1.63626642
50MP0003329_amyloid_beta_deposits1.60615352
51MP0003787_abnormal_imprinting1.57645831
52MP0002089_abnormal_postnatal_growth/wei1.57605848
53MP0001849_ear_inflammation1.50517808
54MP0002075_abnormal_coat/hair_pigmentati1.50053963
55MP0000955_abnormal_spinal_cord1.49668215
56MP0003123_paternal_imprinting1.43235894
57MP0002066_abnormal_motor_capabilities/c1.41112652
58MP0002882_abnormal_neuron_morphology1.37855500
59MP0001984_abnormal_olfaction1.36950408
60MP0004885_abnormal_endolymph1.35461381
61MP0003633_abnormal_nervous_system1.33847592
62MP0001529_abnormal_vocalization1.27951348
63MP0003878_abnormal_ear_physiology1.25537626
64MP0005377_hearing/vestibular/ear_phenot1.25537626
65MP0002095_abnormal_skin_pigmentation1.25258581
66MP0001348_abnormal_lacrimal_gland1.24578795
67MP0001186_pigmentation_phenotype1.23551140
68MP0006276_abnormal_autonomic_nervous1.22237916
69MP0001188_hyperpigmentation1.20492975
70MP0001502_abnormal_circadian_rhythm1.18600985
71MP0003075_altered_response_to1.18598525
72MP0001905_abnormal_dopamine_level1.16662874
73MP0005645_abnormal_hypothalamus_physiol1.15957126
74MP0001958_emphysema1.14654073
75MP0003631_nervous_system_phenotype1.13892727
76MP0004142_abnormal_muscle_tone1.10677199
77MP0005174_abnormal_tail_pigmentation1.10567464
78MP0002152_abnormal_brain_morphology1.09541482
79MP0005503_abnormal_tendon_morphology1.07217387
80MP0008872_abnormal_physiological_respon1.04798189
81MP0001177_atelectasis1.03179572
82MP0008874_decreased_physiological_sensi1.03055377
83MP0003183_abnormal_peptide_metabolism1.00036816
84MP0000751_myopathy0.99582813
85MP0003279_aneurysm0.96809374
86MP0002069_abnormal_eating/drinking_beha0.95391415
87MP0009384_cardiac_valve_regurgitation0.94967963
88MP0005167_abnormal_blood-brain_barrier0.93888143
89MP0003122_maternal_imprinting0.90313503
90MP0003283_abnormal_digestive_organ0.89473045
91MP0000569_abnormal_digit_pigmentation0.88598557
92MP0004272_abnormal_basement_membrane0.87618997
93MP0010386_abnormal_urinary_bladder0.86742919
94MP0004510_myositis0.81431362
95MP0004085_abnormal_heartbeat0.81227342
96MP0008961_abnormal_basal_metabolism0.80041570
97MP0002229_neurodegeneration0.79557695
98MP0005535_abnormal_body_temperature0.79445947
99MP0010234_abnormal_vibrissa_follicle0.78613548
100MP0005499_abnormal_olfactory_system0.78486319
101MP0005394_taste/olfaction_phenotype0.78486319
102MP0005248_abnormal_Harderian_gland0.76711109
103MP0001963_abnormal_hearing_physiology0.76188857
104MP0003632_abnormal_nervous_system0.75971659
105MP0005409_darkened_coat_color0.75175333
106MP0004145_abnormal_muscle_electrophysio0.74316786
107MP0001324_abnormal_eye_pigmentation0.73777964
108MP0004484_altered_response_of0.72251239
109MP0001299_abnormal_eye_distance/0.71924418
110MP0005551_abnormal_eye_electrophysiolog0.71456502
111MP0003690_abnormal_glial_cell0.70838998
112MP0000013_abnormal_adipose_tissue0.70715850
113MP0002090_abnormal_vision0.70293872
114MP0004742_abnormal_vestibular_system0.70113789
115MP0000920_abnormal_myelination0.68737013
116MP0002751_abnormal_autonomic_nervous0.68382939
117MP0005623_abnormal_meninges_morphology0.67559151
118MP0003634_abnormal_glial_cell0.66820591
119MP0002249_abnormal_larynx_morphology0.65863601
120MP0001664_abnormal_digestion0.65848927
121MP0002752_abnormal_somatic_nervous0.64555387
122MP0000631_abnormal_neuroendocrine_gland0.64384820
123MP0000604_amyloidosis0.62565698
124MP0003091_abnormal_cell_migration0.61998487
125MP0009278_abnormal_bone_marrow0.61591587
126MP0001485_abnormal_pinna_reflex0.58253188
127MP0005197_abnormal_uvea_morphology0.56665231
128MP0003566_abnormal_cell_adhesion0.55669395
129MP0003137_abnormal_impulse_conducting0.55492441
130MP0003861_abnormal_nervous_system0.55324475
131MP0004215_abnormal_myocardial_fiber0.55044569
132MP0002938_white_spotting0.54377000
133MP0005508_abnormal_skeleton_morphology0.53467734
134MP0010769_abnormal_survival0.52938721
135MP0001943_abnormal_respiration0.52911084
136MP0010770_preweaning_lethality0.49841121
137MP0002082_postnatal_lethality0.49841121
138MP0010768_mortality/aging0.49705968
139MP0004233_abnormal_muscle_weight0.49192611
140MP0003956_abnormal_body_size0.48727370
141MP0005166_decreased_susceptibility_to0.48028289
142MP0002876_abnormal_thyroid_physiology0.46665151

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.69161920
2Myokymia (HP:0002411)7.87848683
3Focal seizures (HP:0007359)6.27413095
4Visual hallucinations (HP:0002367)5.35942177
5Peripheral hypomyelination (HP:0007182)5.33502550
6Epileptic encephalopathy (HP:0200134)5.16198292
7Febrile seizures (HP:0002373)4.90393093
8Atonic seizures (HP:0010819)4.77827462
9Ocular albinism (HP:0001107)4.71742034
10White forelock (HP:0002211)4.57465835
11Absence seizures (HP:0002121)4.28455013
12Progressive cerebellar ataxia (HP:0002073)4.26915214
13Iris hypopigmentation (HP:0007730)4.23888282
14Heterochromia iridis (HP:0001100)4.09463457
15Generalized tonic-clonic seizures (HP:0002069)4.08934563
16Dialeptic seizures (HP:0011146)3.99432206
17Action tremor (HP:0002345)3.94176828
18Patchy hypopigmentation of hair (HP:0011365)3.80555783
19Broad-based gait (HP:0002136)3.75344272
20Impaired vibration sensation in the lower limbs (HP:0002166)3.71844503
21Poor eye contact (HP:0000817)3.70662932
22Gaze-evoked nystagmus (HP:0000640)3.68900031
23Protrusio acetabuli (HP:0003179)3.64485725
24Distal upper limb amyotrophy (HP:0007149)3.46750234
25Upper limb amyotrophy (HP:0009129)3.46750234
26Dysdiadochokinesis (HP:0002075)3.39863279
27Hand muscle atrophy (HP:0009130)3.38648580
28Depression (HP:0000716)3.38597967
29Amblyopia (HP:0000646)3.33592479
30Ankle clonus (HP:0011448)3.31795453
31Impaired social interactions (HP:0000735)3.29567803
32Abnormal social behavior (HP:0012433)3.29567803
33Hyperventilation (HP:0002883)3.26427160
34Dysmetria (HP:0001310)3.24828274
35Supranuclear gaze palsy (HP:0000605)3.13064940
36Urinary bladder sphincter dysfunction (HP:0002839)3.11972032
37Hypopigmentation of the fundus (HP:0007894)3.09447855
38Anxiety (HP:0000739)3.08675528
39Postural instability (HP:0002172)3.05920774
40Papilledema (HP:0001085)3.02773348
41Truncal ataxia (HP:0002078)2.98128187
42Abnormality of the lower motor neuron (HP:0002366)2.95975309
43Impaired smooth pursuit (HP:0007772)2.93313341
44Mutism (HP:0002300)2.92475390
45Premature rupture of membranes (HP:0001788)2.90107997
46Annular pancreas (HP:0001734)2.87477692
47Abnormal eating behavior (HP:0100738)2.85927242
48Torticollis (HP:0000473)2.85669836
49Hyperacusis (HP:0010780)2.81968570
50Focal dystonia (HP:0004373)2.77673150
51J-shaped sella turcica (HP:0002680)2.76954580
52Stereotypic behavior (HP:0000733)2.76464743
53Cerebral aneurysm (HP:0004944)2.74602781
54Genetic anticipation (HP:0003743)2.73427654
55Aplasia/Hypoplasia of the macula (HP:0008059)2.72207509
56Urinary urgency (HP:0000012)2.68079004
57Excessive salivation (HP:0003781)2.63973969
58Drooling (HP:0002307)2.63973969
59Impaired vibratory sensation (HP:0002495)2.55414234
60Bradykinesia (HP:0002067)2.55067539
61Scanning speech (HP:0002168)2.54518244
62Aplasia/Hypoplasia affecting the retina (HP:0008061)2.53537082
63Akinesia (HP:0002304)2.53371834
64Hemiparesis (HP:0001269)2.52551319
65Hypoplasia of the iris (HP:0007676)2.52474033
66Hypoplasia of the fovea (HP:0007750)2.52167880
67Aplasia/Hypoplasia of the fovea (HP:0008060)2.52167880
68Abnormality of ocular smooth pursuit (HP:0000617)2.52097446
69Cerebral hypomyelination (HP:0006808)2.51876761
70Hemiplegia (HP:0002301)2.48636931
71Intention tremor (HP:0002080)2.46453853
72Absent speech (HP:0001344)2.45522020
73Epileptiform EEG discharges (HP:0011182)2.45413959
74Dysmetric saccades (HP:0000641)2.45136435
75Progressive inability to walk (HP:0002505)2.44112745
76Shallow orbits (HP:0000586)2.43844875
77Vertebral compression fractures (HP:0002953)2.41301610
78Ventricular fibrillation (HP:0001663)2.40027357
79Obstructive sleep apnea (HP:0002870)2.39235669
80Megalencephaly (HP:0001355)2.38841218
81Spastic gait (HP:0002064)2.35356918
82Fetal akinesia sequence (HP:0001989)2.34479572
83Craniofacial dystonia (HP:0012179)2.34261568
84Stridor (HP:0010307)2.33652580
85Status epilepticus (HP:0002133)2.33479084
86Pointed chin (HP:0000307)2.33255389
87Apathy (HP:0000741)2.31188498
88Ulnar claw (HP:0001178)2.30182539
89Diplopia (HP:0000651)2.27029787
90Abnormality of binocular vision (HP:0011514)2.27029787
91Biconcave vertebral bodies (HP:0004586)2.26675510
92EEG with generalized epileptiform discharges (HP:0011198)2.26205408
93Diminished motivation (HP:0000745)2.25949643
94Hypoventilation (HP:0002791)2.22527397
95Incomplete penetrance (HP:0003829)2.22165865
96Ankyloglossia (HP:0010296)2.20562734
97Generalized myoclonic seizures (HP:0002123)2.19592275
98Cerebral inclusion bodies (HP:0100314)2.17430248
99Lower limb amyotrophy (HP:0007210)2.17066833
100Genu recurvatum (HP:0002816)2.16302836
101Hypsarrhythmia (HP:0002521)2.14855611
102Resting tremor (HP:0002322)2.13718421
103Bundle branch block (HP:0011710)2.12878865
104Premature graying of hair (HP:0002216)2.11799227
105Mild short stature (HP:0003502)2.11434745
106Inability to walk (HP:0002540)2.11277543
107Ulnar bowing (HP:0003031)2.11061136
108Neurofibrillary tangles (HP:0002185)2.07529218
109Hammertoe (HP:0001765)2.04155614
110Insidious onset (HP:0003587)2.02517491
111Termporal pattern (HP:0011008)2.02517491
112Lower limb muscle weakness (HP:0007340)2.01196989
113Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.00044934
114Absent epiphyses (HP:0010577)2.00044934
115Achilles tendon contracture (HP:0001771)1.99590452
116Generalized hypopigmentation (HP:0007513)1.98905967
117Alacrima (HP:0000522)1.97957918
118Distal sensory impairment (HP:0002936)1.97838275
119Lower limb asymmetry (HP:0100559)1.96956284
120Atrophic scars (HP:0001075)1.96735255
121Bladder diverticulum (HP:0000015)1.95550435
122Gait ataxia (HP:0002066)1.94667943
123Abnormality of dentin (HP:0010299)1.94411044
124Mitral regurgitation (HP:0001653)1.93077843
125Dysostosis multiplex (HP:0000943)1.92739275
126Wormian bones (HP:0002645)1.91462491
127Abnormality of the fovea (HP:0000493)1.89602154
128Foot dorsiflexor weakness (HP:0009027)1.88651579
129Turricephaly (HP:0000262)1.88637217
130Abnormal EKG (HP:0003115)1.88219248
131Protruding tongue (HP:0010808)1.87353768
132Distal lower limb amyotrophy (HP:0008944)1.86677734
133Decreased motor nerve conduction velocity (HP:0003431)1.85336963
134Delusions (HP:0000746)1.84567582
135Insomnia (HP:0100785)1.83956309
136Abnormality of salivation (HP:0100755)1.83013755
137Blue irides (HP:0000635)1.81954953
138Abnormality of the corticospinal tract (HP:0002492)1.81689898
139Bell-shaped thorax (HP:0001591)1.80173681
140Ankle contracture (HP:0006466)1.79546695
141Nuclear cataract (HP:0100018)1.79357485
142Segmental peripheral demyelination/remyelination (HP:0003481)1.79211632
143Spinal canal stenosis (HP:0003416)1.79200745
144Inappropriate behavior (HP:0000719)1.78280680
145Limb dystonia (HP:0002451)1.78192042
146Spastic paraparesis (HP:0002313)1.77227192
147Broad face (HP:0000283)1.76807053
148Polyphagia (HP:0002591)1.76454508
149Abnormality of the periventricular white matter (HP:0002518)1.76436426
150Morphological abnormality of the inner ear (HP:0011390)1.76354855
151Cervical subluxation (HP:0003308)1.75974178
152Fragile skin (HP:0001030)1.74852538
153Spinal rigidity (HP:0003306)1.73060023
154Sleep apnea (HP:0010535)1.72930868
155Deeply set eye (HP:0000490)1.72727767
156Upper limb muscle weakness (HP:0003484)1.72168631
157Increased variability in muscle fiber diameter (HP:0003557)1.71965617
158Abnormality of saccadic eye movements (HP:0000570)1.71316073
159Onion bulb formation (HP:0003383)1.71285552
160Rapidly progressive (HP:0003678)1.68903163
161Clonus (HP:0002169)1.68594533
162Bowel diverticulosis (HP:0005222)1.67349454
163Neuronal loss in central nervous system (HP:0002529)1.66946594
164Rigidity (HP:0002063)1.65408271
165Increased cerebral lipofuscin (HP:0011813)1.65349637
166Abnormality of the foot musculature (HP:0001436)1.64973098
167Thickened helices (HP:0000391)1.64565769
168Intellectual disability, profound (HP:0002187)1.64513266
169Specific learning disability (HP:0001328)1.64050268
170Increased connective tissue (HP:0009025)1.63662753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.47803833
2NTRK34.77199885
3MAP3K93.97450288
4TRIB33.50625325
5DAPK23.06771511
6MAP3K42.66336063
7MINK12.58377204
8MARK12.43296742
9PRKD32.41626322
10MAP2K72.29112217
11KSR22.28726829
12PAK62.25828368
13RIPK42.22619795
14TAOK22.13266405
15ICK2.13030552
16SIK11.99048238
17DAPK11.99029562
18CAMKK11.91889012
19NTRK21.88527798
20PRPF4B1.85134435
21MAP3K111.83804352
22KSR11.78830363
23MAP3K121.73673954
24MAP2K41.70917484
25TNIK1.67787869
26NTRK11.63486189
27CDK51.58882226
28ARAF1.57577325
29TESK11.53627338
30CASK1.50814369
31MAP3K131.50177721
32PLK21.48606446
33CDK191.46244256
34PKN21.39114298
35STK381.35430871
36FES1.32558207
37PRKD21.28165254
38SIK21.26776587
39GRK51.26592213
40PRKCG1.23938602
41SIK31.21265126
42TYRO31.20071892
43PNCK1.20066791
44RPS6KA21.17993781
45EEF2K1.17861681
46PDGFRA1.17270539
47TAOK11.15812292
48MAPK131.15021130
49MAP3K21.07386729
50CAMK11.07384276
51RAF11.06276470
52SMG11.04066125
53PTK2B1.02602427
54ERN10.97503766
55CAMK2A0.96992832
56UHMK10.96422772
57BMPR20.94496445
58CDK180.92936655
59CDK150.91168050
60MAP2K60.90198768
61STK110.89391626
62MAPK120.87831942
63EPHB10.87521993
64PRKCH0.85844753
65CDK140.85446278
66CAMKK20.84957985
67LATS20.83716663
68SGK4940.82652738
69SGK2230.82652738
70CAMK2B0.82034238
71PTK20.81886400
72CDK11A0.79950390
73PINK10.79291222
74ALK0.78093263
75SGK20.76757659
76PDK10.75841807
77SGK10.73015180
78MARK20.70077001
79PAK40.68557706
80SGK30.66738791
81RET0.66541962
82BMX0.66393479
83TESK20.66324039
84OXSR10.66237772
85PDPK10.65786843
86LIMK10.65326280
87MAP4K10.65037548
88DYRK1A0.63059708
89PAK30.61230494
90MAP3K10.61180681
91DAPK30.60108911
92TNK20.59506964
93MAP3K100.59221788
94TTN0.58764360
95PHKG10.55048461
96PHKG20.55048461
97NME10.54815055
98NEK60.53848026
99MTOR0.53604375
100PRKD10.53301895
101MAP2K30.53030248
102CAMK40.51949091
103MAPK70.50076757
104PTK60.49338182
105PRKG20.49194558
106MAP3K70.48851407
107CCNB10.48564667
108DMPK0.48334331
109RPS6KA30.47826837
110IRAK20.47743227
111CDK120.47707687
112NME20.46524957
113PAK20.46425476
114PRKCZ0.46421084
115ROCK20.46252188
116BRAF0.45741539
117FGR0.44691254
118CSNK1G20.44373680
119LMTK20.43569593
120FYN0.43425604
121GRK60.42765591
122PRKCE0.42571287
123CDC42BPA0.42085070
124DYRK1B0.41250534
125MAP2K10.41001002
126MAPK100.40105739
127RPS6KC10.38535319
128RPS6KL10.38535319
129BLK0.37844019
130CAMK2G0.37458551
131MAP3K60.37419698
132MAP2K20.37399506
133DDR20.35956836
134CAMK1G0.35655851
135BRSK10.35200848
136AKT30.34961808
137CAMK2D0.34954943
138RIPK10.34412496
139FER0.33858927
140NEK10.33678803
141MOS0.32358053
142SCYL20.30018356

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.67059641
2Synaptic vesicle cycle_Homo sapiens_hsa047213.21623199
3Olfactory transduction_Homo sapiens_hsa047403.02534352
4Long-term potentiation_Homo sapiens_hsa047202.83989161
5Circadian entrainment_Homo sapiens_hsa047132.79039594
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66325609
7Glutamatergic synapse_Homo sapiens_hsa047242.64301981
8GABAergic synapse_Homo sapiens_hsa047272.64097747
9Amphetamine addiction_Homo sapiens_hsa050312.60584353
10Morphine addiction_Homo sapiens_hsa050322.57264112
11Salivary secretion_Homo sapiens_hsa049702.27818339
12Dopaminergic synapse_Homo sapiens_hsa047282.17326627
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13424287
14Insulin secretion_Homo sapiens_hsa049112.01335822
15Cholinergic synapse_Homo sapiens_hsa047251.96972826
16Gastric acid secretion_Homo sapiens_hsa049711.95683319
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.95569319
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86199757
19Oxytocin signaling pathway_Homo sapiens_hsa049211.79543630
20Calcium signaling pathway_Homo sapiens_hsa040201.72393756
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71076601
22Renin secretion_Homo sapiens_hsa049241.69469667
23Taste transduction_Homo sapiens_hsa047421.66873238
24Long-term depression_Homo sapiens_hsa047301.65880982
25Cocaine addiction_Homo sapiens_hsa050301.63073103
26Serotonergic synapse_Homo sapiens_hsa047261.58637740
27GnRH signaling pathway_Homo sapiens_hsa049121.53155483
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.43309659
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41614407
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39597726
31Gap junction_Homo sapiens_hsa045401.36312599
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35121085
33cAMP signaling pathway_Homo sapiens_hsa040241.33441209
34Glioma_Homo sapiens_hsa052141.30143261
35Collecting duct acid secretion_Homo sapiens_hsa049661.28447363
36Other glycan degradation_Homo sapiens_hsa005111.24567989
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23735250
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19338799
39Estrogen signaling pathway_Homo sapiens_hsa049151.16371075
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14502498
41Melanogenesis_Homo sapiens_hsa049161.11711098
42ErbB signaling pathway_Homo sapiens_hsa040121.11436574
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11344175
44B cell receptor signaling pathway_Homo sapiens_hsa046621.10388235
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10051250
46Type II diabetes mellitus_Homo sapiens_hsa049301.09874311
47Axon guidance_Homo sapiens_hsa043601.07651671
48Notch signaling pathway_Homo sapiens_hsa043301.07413983
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.05700181
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03007387
51Vascular smooth muscle contraction_Homo sapiens_hsa042701.00366780
52Lysosome_Homo sapiens_hsa041420.99010251
53Acute myeloid leukemia_Homo sapiens_hsa052210.92438355
54Oocyte meiosis_Homo sapiens_hsa041140.92371750
55Nitrogen metabolism_Homo sapiens_hsa009100.92193231
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91979070
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91482381
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.90842362
59Chronic myeloid leukemia_Homo sapiens_hsa052200.90826440
60Focal adhesion_Homo sapiens_hsa045100.87292536
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86923698
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84152960
63Cardiac muscle contraction_Homo sapiens_hsa042600.83301060
64Dorso-ventral axis formation_Homo sapiens_hsa043200.81237866
65Pancreatic secretion_Homo sapiens_hsa049720.81021669
66Choline metabolism in cancer_Homo sapiens_hsa052310.78154388
67VEGF signaling pathway_Homo sapiens_hsa043700.76272156
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76027974
69Dilated cardiomyopathy_Homo sapiens_hsa054140.75925109
70Phototransduction_Homo sapiens_hsa047440.75808856
71Thyroid hormone synthesis_Homo sapiens_hsa049180.75078792
72Vibrio cholerae infection_Homo sapiens_hsa051100.74789662
73MAPK signaling pathway_Homo sapiens_hsa040100.73215918
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69854099
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.67191277
76Colorectal cancer_Homo sapiens_hsa052100.67157505
77Osteoclast differentiation_Homo sapiens_hsa043800.66893968
78AMPK signaling pathway_Homo sapiens_hsa041520.66870295
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66787851
80Rap1 signaling pathway_Homo sapiens_hsa040150.66612853
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64517987
82Ras signaling pathway_Homo sapiens_hsa040140.63932541
83Type I diabetes mellitus_Homo sapiens_hsa049400.63900837
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63281358
85Salmonella infection_Homo sapiens_hsa051320.61403987
86Phagosome_Homo sapiens_hsa041450.61221650
87Thyroid cancer_Homo sapiens_hsa052160.60166006
88ECM-receptor interaction_Homo sapiens_hsa045120.60031599
89Amoebiasis_Homo sapiens_hsa051460.59285021
90Shigellosis_Homo sapiens_hsa051310.57701686
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56120831
92Vitamin B6 metabolism_Homo sapiens_hsa007500.55980523
93Non-small cell lung cancer_Homo sapiens_hsa052230.55692328
94Glucagon signaling pathway_Homo sapiens_hsa049220.55591717
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.54949037
96Proteoglycans in cancer_Homo sapiens_hsa052050.54539754
97Prolactin signaling pathway_Homo sapiens_hsa049170.54149479
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51680036
99Alcoholism_Homo sapiens_hsa050340.51401666
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.51208788
101African trypanosomiasis_Homo sapiens_hsa051430.50796508
102mTOR signaling pathway_Homo sapiens_hsa041500.50432015
103Inositol phosphate metabolism_Homo sapiens_hsa005620.50229166
104Adherens junction_Homo sapiens_hsa045200.50179569
105Hippo signaling pathway_Homo sapiens_hsa043900.48657231
106Endocytosis_Homo sapiens_hsa041440.48224066
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47984997
108HIF-1 signaling pathway_Homo sapiens_hsa040660.46602325
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46267592
110Wnt signaling pathway_Homo sapiens_hsa043100.46158902
111Tuberculosis_Homo sapiens_hsa051520.45833597
112Endometrial cancer_Homo sapiens_hsa052130.43509904
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41191078
114Prion diseases_Homo sapiens_hsa050200.40911102
115Chemokine signaling pathway_Homo sapiens_hsa040620.40639376
116Circadian rhythm_Homo sapiens_hsa047100.40161080
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39509041
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37937026
119Bile secretion_Homo sapiens_hsa049760.37863838
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36881635
121Renal cell carcinoma_Homo sapiens_hsa052110.36185375
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33971344
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33931431
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32744310
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32736044
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32492655
127Insulin signaling pathway_Homo sapiens_hsa049100.32346601
128Ovarian steroidogenesis_Homo sapiens_hsa049130.30821512
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29955305
130Platelet activation_Homo sapiens_hsa046110.27675590
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27202993

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