MMP21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1translesion synthesis (GO:0019985)6.50493734
2cellular response to interleukin-15 (GO:0071350)6.43755819
3negative regulation of DNA repair (GO:0045738)6.35084691
4interferon-gamma secretion (GO:0072643)6.19428130
5fatty acid elongation (GO:0030497)6.09152690
6regulation of protein polyubiquitination (GO:1902914)5.82484237
7lateral sprouting from an epithelium (GO:0060601)5.63199578
8long-chain fatty acid biosynthetic process (GO:0042759)5.60604597
9dendritic spine morphogenesis (GO:0060997)5.50933714
10peptidyl-tyrosine autophosphorylation (GO:0038083)5.40480841
11cytidine deamination (GO:0009972)5.32227268
12cytidine metabolic process (GO:0046087)5.32227268
13cytidine catabolic process (GO:0006216)5.32227268
14piRNA metabolic process (GO:0034587)5.19596579
15cilium or flagellum-dependent cell motility (GO:0001539)4.99985974
16response to interleukin-15 (GO:0070672)4.94372863
17heparan sulfate proteoglycan biosynthetic process (GO:0015012)4.91408270
18negative regulation of protein localization to cell surface (GO:2000009)4.91002911
19granulocyte differentiation (GO:0030851)4.89218762
20gamma-aminobutyric acid signaling pathway (GO:0007214)4.87236643
21negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.85213968
22negative regulation of translation, ncRNA-mediated (GO:0040033)4.85213968
23regulation of translation, ncRNA-mediated (GO:0045974)4.85213968
24pyrimidine ribonucleoside catabolic process (GO:0046133)4.82048127
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.80835437
26DNA strand renaturation (GO:0000733)4.63527978
27regulation of bile acid biosynthetic process (GO:0070857)4.60459296
28transcription from mitochondrial promoter (GO:0006390)4.57315417
29reciprocal DNA recombination (GO:0035825)4.49663293
30reciprocal meiotic recombination (GO:0007131)4.49663293
31retinal cone cell development (GO:0046549)4.46386241
32synapsis (GO:0007129)4.45626897
33lens development in camera-type eye (GO:0002088)4.41395579
34epithelial cilium movement (GO:0003351)4.40344486
35regulation of RNA export from nucleus (GO:0046831)4.38947716
36DNA methylation involved in gamete generation (GO:0043046)4.29433259
37axon ensheathment in central nervous system (GO:0032291)4.28843081
38central nervous system myelination (GO:0022010)4.28843081
39replication fork processing (GO:0031297)4.21392705
40blood vessel maturation (GO:0001955)4.20915351
41neuron recognition (GO:0008038)4.19542961
42tongue development (GO:0043586)4.18148216
43establishment of mitochondrion localization (GO:0051654)4.17823149
44cilium movement (GO:0003341)4.09570997
45retinal rod cell development (GO:0046548)4.05541284
46glutamate receptor signaling pathway (GO:0007215)4.05514359
47peristalsis (GO:0030432)3.98213102
48histone H2A acetylation (GO:0043968)3.96233655
49magnesium ion transport (GO:0015693)3.94115041
50neuron remodeling (GO:0016322)3.92978903
51presynaptic membrane assembly (GO:0097105)3.85496879
52cerebral cortex radially oriented cell migration (GO:0021799)3.80424194
53glycerophospholipid catabolic process (GO:0046475)3.80134425
54gene silencing by RNA (GO:0031047)3.79093234
55dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.74523281
56ionotropic glutamate receptor signaling pathway (GO:0035235)3.71763201
57regulation of NFAT protein import into nucleus (GO:0051532)3.69698787
58urate metabolic process (GO:0046415)3.65907893
59male meiosis (GO:0007140)3.64483446
60postreplication repair (GO:0006301)3.62787155
61establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.60224665
62mitochondrion transport along microtubule (GO:0047497)3.60224665
63positive regulation of cell cycle G2/M phase transition (GO:1902751)3.57532478
64positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.57532478
65photoreceptor cell maintenance (GO:0045494)3.56719420
66neuron cell-cell adhesion (GO:0007158)3.56343873
67regulation of vesicle fusion (GO:0031338)3.53735148
68epithelial cell differentiation involved in kidney development (GO:0035850)3.52588962
69positive regulation of catenin import into nucleus (GO:0035413)3.52387021
70glycosphingolipid biosynthetic process (GO:0006688)3.52309518
71response to methylmercury (GO:0051597)3.51927073
72negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.51898973
73axonal fasciculation (GO:0007413)3.51211040
74vocalization behavior (GO:0071625)3.49758701
75cytoskeletal anchoring at plasma membrane (GO:0007016)3.49081340
76photoreceptor cell development (GO:0042461)3.47208403
77chromosome organization involved in meiosis (GO:0070192)3.40410819
78negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.39706785
79presynaptic membrane organization (GO:0097090)3.38694167
80amyloid precursor protein metabolic process (GO:0042982)3.37092768
81phosphate ion transport (GO:0006817)3.36970395
82neuronal stem cell maintenance (GO:0097150)3.33338406
83dendritic spine organization (GO:0097061)3.30734171
84DNA synthesis involved in DNA repair (GO:0000731)3.29678046
85single strand break repair (GO:0000012)3.26276447
86G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.24378067
87negative regulation of interleukin-2 production (GO:0032703)3.23851454
88eye photoreceptor cell development (GO:0042462)3.21522464
89DNA deamination (GO:0045006)3.19554865
90otic vesicle formation (GO:0030916)3.19413301
91negative regulation of astrocyte differentiation (GO:0048712)3.18472616
92negative regulation of smooth muscle cell differentiation (GO:0051151)3.17908474
93regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.17859580
94lens fiber cell differentiation (GO:0070306)3.16888703
95synaptonemal complex assembly (GO:0007130)3.15039698
96negative regulation of cAMP-mediated signaling (GO:0043951)3.14107697
97positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.13435367
98neuronal ion channel clustering (GO:0045161)3.12696695
99regulation of nucleobase-containing compound transport (GO:0032239)3.12178068
100positive regulation of respiratory burst (GO:0060267)3.11853360
101cell wall macromolecule catabolic process (GO:0016998)3.11092808
102positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.09431184
103long term synaptic depression (GO:0060292)3.08986146
104ER overload response (GO:0006983)3.04607510
105detection of light stimulus involved in visual perception (GO:0050908)3.02952567
106detection of light stimulus involved in sensory perception (GO:0050962)3.02952567
107positive regulation of protein import into nucleus, translocation (GO:0033160)3.02644989
108neuronal action potential propagation (GO:0019227)3.02360294
109myelination (GO:0042552)3.02013991
110regulation of inositol phosphate biosynthetic process (GO:0010919)3.01879031
111heparan sulfate proteoglycan metabolic process (GO:0030201)3.00437992
112DNA methylation (GO:0006306)3.00351613
113DNA alkylation (GO:0006305)3.00351613
114regulation of dendritic spine development (GO:0060998)2.99811325
115keratinocyte development (GO:0003334)2.99809867
116protein localization to synapse (GO:0035418)2.98478189
117regulation of glutamate secretion (GO:0014048)2.98414878
118behavioral response to nicotine (GO:0035095)2.98386405
119L-amino acid import (GO:0043092)2.97960557
120positive regulation of neurological system process (GO:0031646)2.97453551
121iron ion import (GO:0097286)2.97321143
122regulation of dendritic spine morphogenesis (GO:0061001)2.95962480
123regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.95183381
124transmission of nerve impulse (GO:0019226)2.93714694
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93165385
126import into cell (GO:0098657)2.92345190
127regulation of calcium ion import (GO:0090279)2.92223188
128vesicle transport along microtubule (GO:0047496)2.92128449
129intraciliary transport (GO:0042073)2.90877460
130exocrine pancreas development (GO:0031017)2.90002058
131ensheathment of neurons (GO:0007272)2.88836185
132axon ensheathment (GO:0008366)2.88836185
133regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.87347007
134organelle transport along microtubule (GO:0072384)2.86682345
135pyrimidine nucleoside catabolic process (GO:0046135)2.84712405
136synaptonemal complex organization (GO:0070193)2.82113413
137long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.81865386
138neuron-neuron synaptic transmission (GO:0007270)2.81602577
139proteoglycan biosynthetic process (GO:0030166)2.81334209
140regulation of protein import into nucleus, translocation (GO:0033158)2.81185587
141negative regulation of DNA-dependent DNA replication (GO:2000104)2.79935887
142myelin assembly (GO:0032288)2.79333545
143synaptic vesicle exocytosis (GO:0016079)2.78696372
144protein sumoylation (GO:0016925)2.77870007
145regulation of cAMP-dependent protein kinase activity (GO:2000479)2.76652416
146regulation of rhodopsin mediated signaling pathway (GO:0022400)2.75094888
147DNA methylation or demethylation (GO:0044728)2.74839988
148hepatocyte differentiation (GO:0070365)2.72737871
149positive regulation of uterine smooth muscle contraction (GO:0070474)2.72564508
150polyol transport (GO:0015791)2.72500956
151response to folic acid (GO:0051593)2.72128740
152embryonic digestive tract development (GO:0048566)2.70656466
153rhodopsin mediated signaling pathway (GO:0016056)2.70530102
154negative regulation of amino acid transport (GO:0051956)2.70171608
155linoleic acid metabolic process (GO:0043651)2.67519929
156regulation of short-term neuronal synaptic plasticity (GO:0048172)2.66701587
157regulation of pigment cell differentiation (GO:0050932)2.66656898
158sulfur amino acid catabolic process (GO:0000098)2.66608985
159DNA modification (GO:0006304)2.66139642
160artery development (GO:0060840)2.66034118
161regulation of sarcomere organization (GO:0060297)2.64281701
162negative regulation of neurotransmitter transport (GO:0051589)2.63800709
163chaperone-mediated protein transport (GO:0072321)2.63707851
164regulation of glutamate receptor signaling pathway (GO:1900449)2.63388825
165response to histamine (GO:0034776)2.63306727
166positive regulation of dendritic spine development (GO:0060999)2.62250390
167chemosensory behavior (GO:0007635)2.58045514
168regulation of synaptic plasticity (GO:0048167)2.57722959
169positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.56570150
170eye photoreceptor cell differentiation (GO:0001754)2.55834489
171photoreceptor cell differentiation (GO:0046530)2.55834489
172organ growth (GO:0035265)2.53799733
173positive regulation of meiosis (GO:0045836)2.52529683
174synaptic vesicle maturation (GO:0016188)2.50776685
175long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.50533043
176chloride transmembrane transport (GO:1902476)2.50082422
177regulation of extracellular matrix disassembly (GO:0010715)2.49391765
178mesenchymal cell differentiation involved in renal system development (GO:2001012)2.48911534
179mesenchymal cell differentiation involved in kidney development (GO:0072161)2.48911534
180synaptic transmission, glutamatergic (GO:0035249)2.47442449
181fatty-acyl-CoA biosynthetic process (GO:0046949)2.45802999
182glycosylceramide metabolic process (GO:0006677)2.43200365
183cell differentiation involved in kidney development (GO:0061005)2.42366609
184dendrite morphogenesis (GO:0048813)2.41808346
185regulation of neuronal synaptic plasticity (GO:0048168)2.40865805
186chloride transport (GO:0006821)2.38793869
187regulation of synapse structural plasticity (GO:0051823)2.38745924
188negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.38282642
189glutamate secretion (GO:0014047)2.38245245
190positive regulation of meiotic cell cycle (GO:0051446)2.38098575
191positive regulation of membrane potential (GO:0045838)2.37972996
192opsonization (GO:0008228)2.37540290
193embryonic retina morphogenesis in camera-type eye (GO:0060059)2.35655597
194cerebellar granule cell differentiation (GO:0021707)2.35167006
195negative regulation of exocytosis (GO:0045920)2.34135135
196lymphoid progenitor cell differentiation (GO:0002320)2.33318858
197regulation of cytokine production involved in inflammatory response (GO:1900015)10.9175409
198heparin metabolic process (GO:0030202)10.9071283
199heparin biosynthetic process (GO:0030210)10.9071283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human6.52530856
2EZH2_22144423_ChIP-Seq_EOC_Human6.32627800
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.94112010
4GATA1_22025678_ChIP-Seq_K562_Human4.79331853
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.02681537
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.39852999
7ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.87622079
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85908570
9AR_21572438_ChIP-Seq_LNCaP_Human2.75711575
10IGF1R_20145208_ChIP-Seq_DFB_Human2.66568624
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52148187
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51476101
13TAF15_26573619_Chip-Seq_HEK293_Human2.39739931
14GBX2_23144817_ChIP-Seq_PC3_Human2.38036334
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.29647806
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.23402913
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23077349
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20655774
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20655774
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19515521
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14863092
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.14370931
23WT1_19549856_ChIP-ChIP_CCG9911_Human2.13693420
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.09385780
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08315096
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06716476
27MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05274021
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.03820495
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00280229
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.98934918
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97933228
32* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.85886670
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84008271
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.83356735
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83143531
36E2F7_22180533_ChIP-Seq_HELA_Human1.82294102
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81782638
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81630985
39EWS_26573619_Chip-Seq_HEK293_Human1.78436646
40VDR_22108803_ChIP-Seq_LS180_Human1.78297705
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74465291
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.71979144
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70362065
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66554715
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.64029771
46P300_19829295_ChIP-Seq_ESCs_Human1.63320085
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63202794
48DROSHA_22980978_ChIP-Seq_HELA_Human1.63124781
49TP53_16413492_ChIP-PET_HCT116_Human1.62009324
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60175609
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59154354
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57123770
53REST_21632747_ChIP-Seq_MESCs_Mouse1.56890810
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55892777
55ZNF274_21170338_ChIP-Seq_K562_Hela1.53760009
56SMAD4_21799915_ChIP-Seq_A2780_Human1.50439601
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50196927
58KDM2B_26808549_Chip-Seq_REH_Human1.48248989
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48158553
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47504829
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45777640
62FUS_26573619_Chip-Seq_HEK293_Human1.44900845
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.44830192
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44647377
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.41326875
66* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41325512
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39408284
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39408284
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39343656
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37748691
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31260358
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.29785134
73RARB_27405468_Chip-Seq_BRAIN_Mouse1.25913966
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24444011
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22075967
76ELK4_26923725_Chip-Seq_MESODERM_Mouse1.22049138
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21912657
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21001760
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20328825
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19843836
81RNF2_27304074_Chip-Seq_NSC_Mouse1.19479056
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.19235956
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17268694
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16998313
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13801205
86WDR5_24793694_ChIP-Seq_LNCAP_Human1.13791583
87JUN_21703547_ChIP-Seq_K562_Human1.13302951
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12503405
89RXR_22108803_ChIP-Seq_LS180_Human1.12388087
90* RING1B_27294783_Chip-Seq_ESCs_Mouse1.12062776
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11140746
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.10919916
93TCF4_23295773_ChIP-Seq_U87_Human1.09196825
94STAT3_23295773_ChIP-Seq_U87_Human1.07908551
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07745397
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.07653921
97RING1B_27294783_Chip-Seq_NPCs_Mouse1.07595066
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07245168
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07212064
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07050275
101ER_23166858_ChIP-Seq_MCF-7_Human1.06978208
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05050331
103MYC_18940864_ChIP-ChIP_HL60_Human1.04968897
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04967451
105NCOR_22424771_ChIP-Seq_293T_Human1.04518065
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04441800
107IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04006835
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03627459
109SMAD3_21741376_ChIP-Seq_ESCs_Human1.03521923
110RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02944706
111TP53_18474530_ChIP-ChIP_U2OS_Human1.02827335
112SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02641719
113PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01874336
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01669700
115BCAT_22108803_ChIP-Seq_LS180_Human1.01331124
116TAF2_19829295_ChIP-Seq_ESCs_Human1.00767427
117MYC_19829295_ChIP-Seq_ESCs_Human1.00470001
118RUNX2_22187159_ChIP-Seq_PCA_Human1.00347421
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.00285305
120TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00174047
121RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99937234
122SOX2_19829295_ChIP-Seq_ESCs_Human0.99283537
123NANOG_19829295_ChIP-Seq_ESCs_Human0.99283537
124SMAD4_21741376_ChIP-Seq_EPCs_Human0.99092578
125E2F1_17053090_ChIP-ChIP_MCF-7_Human0.98902395
126NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98369366
127GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97024420
128AHR_22903824_ChIP-Seq_MCF-7_Human0.96057408
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95873592
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95587594
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95445745
132P53_22387025_ChIP-Seq_ESCs_Mouse0.94386206
133CIITA_25753668_ChIP-Seq_RAJI_Human0.93460016
134FLI1_27457419_Chip-Seq_LIVER_Mouse0.93256652
135SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93222941
136REST_18959480_ChIP-ChIP_MESCs_Mouse0.92578287
137FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92209313
138FOXA1_25329375_ChIP-Seq_VCAP_Human0.92209313
139CBP_20019798_ChIP-Seq_JUKART_Human0.91945723
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91945723
141GATA3_21878914_ChIP-Seq_MCF-7_Human0.91760416
142TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90122304
143SOX2_21211035_ChIP-Seq_LN229_Gbm0.89004600
144PRDM14_20953172_ChIP-Seq_ESCs_Human0.88575550
145P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87980413
146HOXB7_26014856_ChIP-Seq_BT474_Human0.87468036
147TCF4_22108803_ChIP-Seq_LS180_Human0.87391196
148ERA_21632823_ChIP-Seq_H3396_Human0.87258600
149SOX2_18555785_Chip-Seq_ESCs_Mouse0.87196597
150AR_25329375_ChIP-Seq_VCAP_Human0.87114541
151EZH2_27294783_Chip-Seq_NPCs_Mouse0.86886140
152FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86586859
153BCL6_27268052_Chip-Seq_Bcells_Human0.86547036
154OCT4_20526341_ChIP-Seq_ESCs_Human0.86010897
155FLI1_21867929_ChIP-Seq_TH2_Mouse0.85674860
156TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84731417
157PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84046683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.82401892
2MP0005377_hearing/vestibular/ear_phenot4.52900664
3MP0003878_abnormal_ear_physiology4.52900664
4MP0004270_analgesia3.72832650
5MP0003880_abnormal_central_pattern3.70084593
6MP0005257_abnormal_intraocular_pressure3.50805226
7MP0000566_synostosis3.46221283
8MP0004859_abnormal_synaptic_plasticity3.33968348
9MP0005409_darkened_coat_color3.32901410
10MP0003329_amyloid_beta_deposits3.14960701
11MP0008057_abnormal_DNA_replication3.06356852
12MP0009697_abnormal_copulation2.91855502
13MP0003950_abnormal_plasma_membrane2.88400602
14MP0001188_hyperpigmentation2.78219032
15MP0003635_abnormal_synaptic_transmissio2.77275013
16MP0000920_abnormal_myelination2.70271107
17MP0003123_paternal_imprinting2.66808753
18MP0009745_abnormal_behavioral_response2.65935105
19MP0009379_abnormal_foot_pigmentation2.57403181
20MP0001486_abnormal_startle_reflex2.55542251
21MP0002064_seizures2.34053323
22MP0004133_heterotaxia2.33558252
23MP0004742_abnormal_vestibular_system2.26099108
24MP0002063_abnormal_learning/memory/cond2.21613635
25MP0003303_peritoneal_inflammation2.16808456
26MP0003121_genomic_imprinting2.08391048
27MP0001440_abnormal_grooming_behavior2.06793005
28MP0005451_abnormal_body_composition2.05954760
29MP0000604_amyloidosis2.03531322
30MP0000427_abnormal_hair_cycle2.03525084
31MP0000778_abnormal_nervous_system2.03049620
32MP0002272_abnormal_nervous_system1.98179821
33MP0002168_other_aberrant_phenotype1.98045066
34MP0002332_abnormal_exercise_endurance1.97956703
35MP0002160_abnormal_reproductive_system1.94853055
36MP0002572_abnormal_emotion/affect_behav1.91564695
37MP0009046_muscle_twitch1.90829527
38MP0003632_abnormal_nervous_system1.88345501
39MP0002697_abnormal_eye_size1.86711155
40MP0003122_maternal_imprinting1.85960130
41MP0002733_abnormal_thermal_nociception1.80037415
42MP0005423_abnormal_somatic_nervous1.72150043
43MP0000462_abnormal_digestive_system1.71832211
44MP0010030_abnormal_orbit_morphology1.71313314
45MP0008789_abnormal_olfactory_epithelium1.71199615
46MP0001661_extended_life_span1.69668791
47MP0008775_abnormal_heart_ventricle1.69477049
48MP0006036_abnormal_mitochondrial_physio1.66870362
49MP0004510_myositis1.64651551
50MP0008004_abnormal_stomach_pH1.64490966
51MP0002734_abnormal_mechanical_nocicepti1.60745743
52MP0002067_abnormal_sensory_capabilities1.60168566
53MP0010368_abnormal_lymphatic_system1.58851162
54MP0003724_increased_susceptibility_to1.57640981
55MP0003787_abnormal_imprinting1.54606564
56MP0001968_abnormal_touch/_nociception1.54089982
57MP0001501_abnormal_sleep_pattern1.53083749
58MP0002653_abnormal_ependyma_morphology1.51671327
59MP0000383_abnormal_hair_follicle1.49271063
60MP0001970_abnormal_pain_threshold1.48244853
61MP0002938_white_spotting1.44015900
62MP0008875_abnormal_xenobiotic_pharmacok1.41522925
63MP0005551_abnormal_eye_electrophysiolog1.38952890
64MP0006035_abnormal_mitochondrial_morpho1.37941810
65MP0000428_abnormal_craniofacial_morphol1.35599445
66MP0002210_abnormal_sex_determination1.35246267
67MP0010678_abnormal_skin_adnexa1.34443381
68MP0005395_other_phenotype1.33261729
69MP0004272_abnormal_basement_membrane1.32134134
70MP0005389_reproductive_system_phenotype1.31967894
71MP0003938_abnormal_ear_development1.31474131
72MP0009053_abnormal_anal_canal1.30007630
73MP0001905_abnormal_dopamine_level1.27952314
74MP0001929_abnormal_gametogenesis1.27877105
75MP0004043_abnormal_pH_regulation1.27815067
76MP0005084_abnormal_gallbladder_morpholo1.27335714
77MP0001299_abnormal_eye_distance/1.26840425
78MP0005671_abnormal_response_to1.24910654
79MP0003690_abnormal_glial_cell1.24187016
80MP0006072_abnormal_retinal_apoptosis1.20768831
81MP0003631_nervous_system_phenotype1.18974279
82MP0003195_calcinosis1.18389100
83MP0002882_abnormal_neuron_morphology1.17022942
84MP0002735_abnormal_chemical_nociception1.16570691
85MP0002066_abnormal_motor_capabilities/c1.16546454
86MP0003634_abnormal_glial_cell1.16361573
87MP0004145_abnormal_muscle_electrophysio1.14624995
88MP0003828_pulmonary_edema1.14067771
89MP0001502_abnormal_circadian_rhythm1.12874811
90MP0008058_abnormal_DNA_repair1.12112292
91MP0008874_decreased_physiological_sensi1.11266191
92MP0000751_myopathy1.10916117
93MP0001764_abnormal_homeostasis1.09376585
94MP0009780_abnormal_chondrocyte_physiolo1.09368938
95MP0000653_abnormal_sex_gland1.09204336
96MP0002184_abnormal_innervation1.09053918
97MP0003718_maternal_effect1.07836464
98MP0001145_abnormal_male_reproductive1.07159685
99MP0005394_taste/olfaction_phenotype1.07060779
100MP0005499_abnormal_olfactory_system1.07060779
101MP0009765_abnormal_xenobiotic_induced1.05654475
102MP0002837_dystrophic_cardiac_calcinosis1.05635149
103MP0002102_abnormal_ear_morphology1.05028131
104MP0002822_catalepsy1.03487054
105MP0000358_abnormal_cell_content/1.03460313
106MP0002095_abnormal_skin_pigmentation1.02360354
107MP0003136_yellow_coat_color1.01936728
108MP0003698_abnormal_male_reproductive1.01866836
109MP0002282_abnormal_trachea_morphology1.01433264
110MP0001485_abnormal_pinna_reflex1.00628602
111MP0004019_abnormal_vitamin_homeostasis0.99620324
112MP0001348_abnormal_lacrimal_gland0.97767949
113MP0004811_abnormal_neuron_physiology0.97695290
114MP0001119_abnormal_female_reproductive0.94505565
115MP0000465_gastrointestinal_hemorrhage0.93865737
116MP0002229_neurodegeneration0.93804176
117MP0003646_muscle_fatigue0.92332293
118MP0003137_abnormal_impulse_conducting0.91244364
119MP0001545_abnormal_hematopoietic_system0.91204441
120MP0005397_hematopoietic_system_phenotyp0.91204441
121MP0001963_abnormal_hearing_physiology0.90994659
122MP0003937_abnormal_limbs/digits/tail_de0.90595586
123MP0002405_respiratory_system_inflammati0.88613670
124MP0005310_abnormal_salivary_gland0.88601372
125MP0002152_abnormal_brain_morphology0.88013045
126MP0000955_abnormal_spinal_cord0.87629920
127MP0000569_abnormal_digit_pigmentation0.87091998
128MP0003045_fibrosis0.84892464
129MP0004885_abnormal_endolymph0.84316395
130MP0005365_abnormal_bile_salt0.84298389
131MP0005647_abnormal_sex_gland0.84024667
132MP0004142_abnormal_muscle_tone0.83985615
133MP0006292_abnormal_olfactory_placode0.83779884
134MP0003786_premature_aging0.83736951
135MP0002557_abnormal_social/conspecific_i0.82396449
136MP0005386_behavior/neurological_phenoty0.81426107
137MP0004924_abnormal_behavior0.81426107
138MP0002752_abnormal_somatic_nervous0.80621303
139MP0005195_abnormal_posterior_eye0.80579224
140MP0003633_abnormal_nervous_system0.79814641
141MP0000015_abnormal_ear_pigmentation0.79705758
142MP0003879_abnormal_hair_cell0.77659368
143MP0005220_abnormal_exocrine_pancreas0.77130559
144MP0008569_lethality_at_weaning0.76661221
145MP0003385_abnormal_body_wall0.75781446
146MP0001873_stomach_inflammation0.75773092
147MP0000579_abnormal_nail_morphology0.75691233
148MP0005248_abnormal_Harderian_gland0.72355009
149MP0005266_abnormal_metabolism0.71601588
150MP0000230_abnormal_systemic_arterial0.71515131
151MP0004147_increased_porphyrin_level0.71085497
152MP0001756_abnormal_urination0.70748124
153MP0004215_abnormal_myocardial_fiber0.70441571
154MP0005174_abnormal_tail_pigmentation0.69979183
155MP0009764_decreased_sensitivity_to0.69892851
156MP0005623_abnormal_meninges_morphology0.69740405
157MP0002138_abnormal_hepatobiliary_system0.67248438
158MP0001986_abnormal_taste_sensitivity0.67155585
159MP0000749_muscle_degeneration0.66853440
160MP0003172_abnormal_lysosome_physiology0.66833224
161MP0001944_abnormal_pancreas_morphology0.66687138
162MP0005391_vision/eye_phenotype0.65965760
163MP0002736_abnormal_nociception_after0.65770725
164MP0003936_abnormal_reproductive_system0.65300427
165MP0000026_abnormal_inner_ear0.64578470
166MP0001346_abnormal_lacrimal_gland0.63441456
167MP0002295_abnormal_pulmonary_circulatio0.62774660
168MP0005193_abnormal_anterior_eye0.62091142
169MP0001919_abnormal_reproductive_system0.61705832
170MP0002909_abnormal_adrenal_gland0.60859336
171MP0002069_abnormal_eating/drinking_beha0.60644540
172MP0000631_abnormal_neuroendocrine_gland0.60232538
173MP0002876_abnormal_thyroid_physiology0.60030974
174MP0005379_endocrine/exocrine_gland_phen0.59936184
175MP0002098_abnormal_vibrissa_morphology0.59766535
176MP0002796_impaired_skin_barrier0.59239767
177MP0001177_atelectasis0.58965040
178MP0005253_abnormal_eye_physiology0.56981812

Predicted human phenotypes

RankGene SetZ-score
1Zonular cataract (HP:0010920)8.09417707
2Parakeratosis (HP:0001036)7.24070037
3Hypoplastic nipples (HP:0002557)6.81470405
4Focal motor seizures (HP:0011153)4.86608685
5Generalized aminoaciduria (HP:0002909)4.73896457
6Rib fusion (HP:0000902)4.55490892
7Neurofibrillary tangles (HP:0002185)4.30922091
8Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.17699765
9Bifid scrotum (HP:0000048)4.04545714
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.96849323
11Cerebral inclusion bodies (HP:0100314)3.87313584
12Anomalous pulmonary venous return (HP:0010772)3.87002192
13Testicular atrophy (HP:0000029)3.82823992
14Degeneration of the lateral corticospinal tracts (HP:0002314)3.78816712
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.78816712
16Focal seizures (HP:0007359)3.75138321
17Partial agenesis of the corpus callosum (HP:0001338)3.67476410
18Sensory axonal neuropathy (HP:0003390)3.65235647
19Oligodactyly (HP:0012165)3.60497778
20Abnormality of the corticospinal tract (HP:0002492)3.58496245
21Hypophosphatemic rickets (HP:0004912)3.57621799
22Pancreatic fibrosis (HP:0100732)3.56565924
23Bony spicule pigmentary retinopathy (HP:0007737)3.54889926
24Insidious onset (HP:0003587)3.42038099
25Termporal pattern (HP:0011008)3.42038099
26Aplasia/Hypoplasia of the nipples (HP:0006709)3.40930615
27Axonal loss (HP:0003447)3.40068977
28Abnormal rod and cone electroretinograms (HP:0008323)3.36841828
29Abolished electroretinogram (ERG) (HP:0000550)3.35426899
30Oligodactyly (hands) (HP:0001180)3.32446789
31Hyperventilation (HP:0002883)3.32318781
32True hermaphroditism (HP:0010459)3.31229413
33Congenital stationary night blindness (HP:0007642)3.29802618
34Abnormality of macular pigmentation (HP:0008002)3.29769353
35Hypoglycemic coma (HP:0001325)3.29269469
36Aplasia/Hypoplasia of the tongue (HP:0010295)3.28402452
37Abnormality of the pulmonary veins (HP:0011718)3.27244554
38Renal hypoplasia (HP:0000089)3.26849742
39Congenital ichthyosiform erythroderma (HP:0007431)3.22249774
40Attenuation of retinal blood vessels (HP:0007843)3.21183156
41Wide intermamillary distance (HP:0006610)3.18281511
42Scanning speech (HP:0002168)3.16111943
43Drooling (HP:0002307)3.08518160
44Excessive salivation (HP:0003781)3.08518160
45Epileptic encephalopathy (HP:0200134)3.07411029
46Chronic hepatic failure (HP:0100626)2.99540925
47Nephronophthisis (HP:0000090)2.98535014
48Severe visual impairment (HP:0001141)2.91412453
49Fair hair (HP:0002286)2.90056047
50Postaxial foot polydactyly (HP:0001830)2.86251842
51Molar tooth sign on MRI (HP:0002419)2.84740835
52Abnormality of midbrain morphology (HP:0002418)2.84740835
53Atonic seizures (HP:0010819)2.81816008
54Febrile seizures (HP:0002373)2.79953332
55Pancreatic cysts (HP:0001737)2.79753536
56Osteomalacia (HP:0002749)2.76626886
57Myokymia (HP:0002411)2.75570141
58Chorioretinal atrophy (HP:0000533)2.74868708
59Papilledema (HP:0001085)2.70639901
60Supranuclear gaze palsy (HP:0000605)2.70080615
61Abnormality of the phalanges of the hallux (HP:0010057)2.67338511
62Retinal dysplasia (HP:0007973)2.62406137
63Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.61064317
64Abnormality of DNA repair (HP:0003254)2.61029069
65Aplasia cutis congenita (HP:0001057)2.57795382
66Poikiloderma (HP:0001029)2.57712252
67Morphological abnormality of the pyramidal tract (HP:0002062)2.57150391
68Generalized tonic-clonic seizures (HP:0002069)2.56381989
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.56009043
70Renal cortical cysts (HP:0000803)2.55051521
71Absent speech (HP:0001344)2.54073354
72Optic nerve hypoplasia (HP:0000609)2.51663405
73Absence seizures (HP:0002121)2.51082108
74Recurrent cutaneous fungal infections (HP:0011370)2.49772312
75Chronic mucocutaneous candidiasis (HP:0002728)2.49772312
76Choroideremia (HP:0001139)2.49283377
77Pili torti (HP:0003777)2.48206205
78Ectopic kidney (HP:0000086)2.47686000
79Psychosis (HP:0000709)2.47613206
80Growth hormone deficiency (HP:0000824)2.45153389
81Enlarged penis (HP:0000040)2.39432647
82Dyschromatopsia (HP:0007641)2.38526030
83Broad-based gait (HP:0002136)2.37410802
84Facial hemangioma (HP:0000329)2.36530061
85Widely spaced teeth (HP:0000687)2.34948498
86Dynein arm defect of respiratory motile cilia (HP:0012255)2.34930602
87Absent/shortened dynein arms (HP:0200106)2.34930602
88Congenital sensorineural hearing impairment (HP:0008527)2.33559893
89Akinesia (HP:0002304)2.32662539
90Spastic gait (HP:0002064)2.32451391
91Duplicated collecting system (HP:0000081)2.32024102
92Proximal tubulopathy (HP:0000114)2.29005025
93Abnormality of the renal medulla (HP:0100957)2.28987687
94Severe Myopia (HP:0011003)2.28022978
95Abnormality of salivation (HP:0100755)2.27607837
96Dialeptic seizures (HP:0011146)2.24711971
97Calf muscle hypertrophy (HP:0008981)2.24578262
98Popliteal pterygium (HP:0009756)2.23939222
99Hyperinsulinemic hypoglycemia (HP:0000825)2.22392857
100Status epilepticus (HP:0002133)2.21410583
101Congenital, generalized hypertrichosis (HP:0004540)2.21294174
102Abnormal biliary tract physiology (HP:0012439)2.21107995
103Bile duct proliferation (HP:0001408)2.21107995
104Amyotrophic lateral sclerosis (HP:0007354)2.21041074
105Muscle hypertrophy of the lower extremities (HP:0008968)2.21028979
106Gait imbalance (HP:0002141)2.20936669
107Abnormal number of incisors (HP:0011064)2.19319472
108Generalized hypopigmentation of hair (HP:0011358)2.18806756
109Multicystic kidney dysplasia (HP:0000003)2.18577464
110Dry hair (HP:0011359)2.18330088
111Congenital primary aphakia (HP:0007707)2.16857096
112Papillary thyroid carcinoma (HP:0002895)2.15679107
113Protruding tongue (HP:0010808)2.15443853
114Delayed CNS myelination (HP:0002188)2.15343015
115Medial flaring of the eyebrow (HP:0010747)2.14096439
116Abnormal ciliary motility (HP:0012262)2.11183002
117Onion bulb formation (HP:0003383)2.11144639
118Intellectual disability, moderate (HP:0002342)2.09668941
119Elfin facies (HP:0004428)2.08458377
120Holoprosencephaly (HP:0001360)2.07153978
121Reticulocytopenia (HP:0001896)2.07070969
122Bone marrow hypocellularity (HP:0005528)2.06843013
123Abnormal respiratory motile cilium physiology (HP:0012261)2.06611426
124Abnormality of dental color (HP:0011073)2.06093434
125Anencephaly (HP:0002323)2.06079317
126Dysmetria (HP:0001310)2.06016478
127Type II lissencephaly (HP:0007260)2.04366258
128Abnormal hair whorl (HP:0010721)2.03145619
129Capillary hemangiomas (HP:0005306)2.02942530
130Steppage gait (HP:0003376)2.02852254
131Hypophosphatemia (HP:0002148)2.01820473
132Buphthalmos (HP:0000557)2.00659478
133Neuronal loss in central nervous system (HP:0002529)2.00023960
134Progressive inability to walk (HP:0002505)1.99349970
135Decreased central vision (HP:0007663)1.97439369
136Postaxial hand polydactyly (HP:0001162)1.95322163
137Prolonged neonatal jaundice (HP:0006579)1.95019893
138Preaxial hand polydactyly (HP:0001177)1.94545308
139Mixed hearing impairment (HP:0000410)1.94296273
140Pancytopenia (HP:0001876)1.94032289
141Hypoglycemic seizures (HP:0002173)1.92788426
142Median cleft lip (HP:0000161)1.92278941
143Micropenis (HP:0000054)1.91534632
144Clumsiness (HP:0002312)1.90286879
145Amblyopia (HP:0000646)1.89760850
146Nephrogenic diabetes insipidus (HP:0009806)1.89164914
147Pendular nystagmus (HP:0012043)1.88905736
148Abnormality of the renal cortex (HP:0011035)1.88780304
149Concave nail (HP:0001598)1.88523365
150Generalized myoclonic seizures (HP:0002123)1.87297010
151Sparse lateral eyebrow (HP:0005338)1.86264682
152Duplication of thumb phalanx (HP:0009942)1.86236167
153Death in childhood (HP:0003819)1.85265318
154Chorioretinal coloboma (HP:0000567)1.81977374
155Depressed nasal tip (HP:0000437)1.81932511
156Tented upper lip vermilion (HP:0010804)1.80923363
157Abnormality of the renal collecting system (HP:0004742)1.80892273
158Conjunctival telangiectasia (HP:0000524)1.80871623
159Aplasia of the musculature (HP:0100854)1.80206233
160Relative macrocephaly (HP:0004482)1.79485642
161Hemiparesis (HP:0001269)1.79397699
162Congenital cataract (HP:0000519)1.78706658
163Abnormal hair laboratory examination (HP:0003328)1.78679217
164J-shaped sella turcica (HP:0002680)1.78407215
165Abnormality of the incisor (HP:0000676)1.77897746
166Joint hemorrhage (HP:0005261)1.77350757
167Teleangiectasia of the skin (HP:0100585)1.76847209
168Erythroderma (HP:0001019)1.74589404
169Pruritus (HP:0000989)1.74488944
170Congenital malformation of the right heart (HP:0011723)1.72938657
171Double outlet right ventricle (HP:0001719)1.72938657
172Ectropion (HP:0000656)1.72819885
173Lip pit (HP:0100267)1.71321140
174Diaphragmatic weakness (HP:0009113)1.70402417
175Abnormality of homocysteine metabolism (HP:0010919)1.70290992
176Homocystinuria (HP:0002156)1.70290992
177Congenital hepatic fibrosis (HP:0002612)1.69486858
178Nasolacrimal duct obstruction (HP:0000579)1.69424683
179Rickets (HP:0002748)1.68339034
180Symptomatic seizures (HP:0011145)1.68111619
181Aplasia/Hypoplasia of the tibia (HP:0005772)1.67657382
182Aplasia/Hypoplasia involving the musculature (HP:0001460)1.67401468
183Central scotoma (HP:0000603)1.67222226
184Infantile muscular hypotonia (HP:0008947)1.65382330
185Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.64540090
186Abnormal respiratory motile cilium morphology (HP:0005938)1.64474895
187Abnormal respiratory epithelium morphology (HP:0012253)1.64474895
188Corneal erosion (HP:0200020)1.64421367
189Rectal fistula (HP:0100590)1.63992670
190Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.62948070
191Abnormality of the vasculature of the conjunctiva (HP:0008054)1.62778875
192Anxiety (HP:0000739)1.62229353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1JAK34.29729036
2MAP3K104.15455558
3RIPK43.87064186
4PNCK3.61598595
5BLK3.41891061
6ADRBK23.02977322
7MAPK152.85152856
8PBK2.73801736
9TNIK2.62253006
10INSRR2.60840691
11MAP3K112.44639946
12DAPK22.43238091
13OXSR12.36003770
14MAP4K22.34870941
15DMPK2.29411365
16TXK2.26888652
17CAMK1D2.24725604
18NTRK22.22093610
19NUAK12.21001419
20PIK3CG2.13099924
21EPHA41.98439399
22CASK1.95560438
23CLK11.94495675
24WNK41.93102261
25MKNK11.90971288
26PKN11.87265705
27MKNK21.86253787
28FES1.82727325
29BMPR21.79981875
30MAPK71.74039749
31NTRK31.73462145
32PINK11.71041642
33CDK191.69619644
34CCNB11.67820817
35STK391.67491324
36NTRK11.66251164
37ICK1.64598242
38LATS11.59955844
39TAOK31.59561418
40UHMK11.58918146
41PAK31.56690210
42MARK11.45204847
43SIK21.44949511
44CAMK1G1.44128279
45STK241.43988546
46ROCK21.35534951
47PRPF4B1.33371876
48STK31.31780778
49DYRK1A1.21274000
50SRPK11.21229613
51MAPKAPK51.20729834
52EPHB11.20475542
53STK38L1.20253508
54MAP2K41.18351093
55FGFR21.18033873
56CHEK21.15646142
57MAP3K51.08262416
58LIMK11.07750521
59CDC42BPA1.07061611
60PLK21.04376273
61PAK61.04225477
62GRK71.01894690
63PRKD21.01148232
64RAF10.99952960
65BTK0.99613148
66BCKDK0.97852765
67MARK20.93589425
68CDK50.90959385
69PASK0.90383390
70WNK10.86911360
71TAOK10.86214630
72PRKCQ0.83028543
73MAP3K130.78996720
74AURKA0.78355503
75YES10.76938685
76MST1R0.74842520
77TGFBR10.74440191
78GRK10.73489486
79CAMK2A0.69450995
80CDK150.69358866
81ZAK0.67485430
82BMPR1B0.66217572
83CDK180.65893683
84STK110.63642159
85CAMK10.62990386
86FRK0.62657861
87FYN0.61372478
88DYRK30.61179180
89BCR0.61008874
90CAMK2B0.58896941
91BRD40.57657850
92CDK11A0.57321950
93MAP3K120.57270157
94DAPK10.56802159
95MAP4K10.56761696
96MAP3K90.56652529
97TLK10.56189526
98PRKCG0.56130086
99RPS6KC10.55761348
100RPS6KL10.55761348
101CSNK1A1L0.54574477
102MOS0.54501731
103MAPK120.54371490
104CDK140.53745340
105ABL20.53534902
106WNK30.53499852
107RPS6KB10.52761852
108GRK60.50581381
109MAP3K140.48886191
110IKBKB0.48865599
111TAOK20.48826495
112MAPK130.48772405
113MAPKAPK30.48139365
114MAPK40.47796104
115CHEK10.46684914
116CDK80.46047079
117ACVR1B0.45964796
118PRKG10.45660439
119LYN0.45579738
120PRKCH0.45368385
121CSNK1G10.42480926
122DAPK30.42191377
123GRK50.40569217
124DDR20.40236925
125SGK10.40089895
126CSNK1D0.39860663
127CSK0.38127845
128LCK0.37906337
129IKBKE0.36386146
130EPHB20.35799403
131RPS6KA60.34868749
132PTK60.34739451
133CSNK1G30.34062611
134KSR20.33963524
135ATM0.33886592
136MAP3K70.33585602
137MAP3K20.32986192
138SYK0.31643852
139MELK0.30723122
140ITK0.29904533
141PAK10.29862424
142FGR0.29355021
143PRKACA0.28895667
144PRKCE0.28248927
145CSNK1E0.27371549
146ATR0.26136145
147CAMK2D0.26126989
148ADRBK10.26070417
149NEK60.25553990
150CDC70.25046999
151PRKCB0.24486764
152TYRO30.24193951
153PRKACG0.24174686
154MAPK100.22939175
155PRKCD0.22665772
156CSNK1A10.22323508
157TGFBR20.22245081
158PRKCA0.22155472
159IGF1R0.22097366
160DYRK20.21476736
161MTOR0.21124957
162KDR0.21101906
163VRK10.18672936
164GSK3B0.18627502

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005345.52730119
2Nicotine addiction_Homo sapiens_hsa050334.26722843
3Homologous recombination_Homo sapiens_hsa034404.07082798
4Steroid biosynthesis_Homo sapiens_hsa001003.13809367
5Fanconi anemia pathway_Homo sapiens_hsa034603.12701255
6Graft-versus-host disease_Homo sapiens_hsa053322.97477465
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82027537
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.65507123
9Glutamatergic synapse_Homo sapiens_hsa047242.53312538
10Fatty acid elongation_Homo sapiens_hsa000622.52674892
11GABAergic synapse_Homo sapiens_hsa047272.41794792
12Axon guidance_Homo sapiens_hsa043602.38873811
13Serotonergic synapse_Homo sapiens_hsa047262.38708853
14Morphine addiction_Homo sapiens_hsa050322.37097987
15Long-term depression_Homo sapiens_hsa047302.18526088
16Hedgehog signaling pathway_Homo sapiens_hsa043402.07699148
17Salivary secretion_Homo sapiens_hsa049702.00930938
18Taste transduction_Homo sapiens_hsa047421.93869520
19Histidine metabolism_Homo sapiens_hsa003401.92306201
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82188934
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79817279
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.79605129
23Regulation of autophagy_Homo sapiens_hsa041401.64131538
24Circadian entrainment_Homo sapiens_hsa047131.61564463
25Oxytocin signaling pathway_Homo sapiens_hsa049211.61149560
26Amphetamine addiction_Homo sapiens_hsa050311.57249816
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56937597
28Basal cell carcinoma_Homo sapiens_hsa052171.54032912
29Antigen processing and presentation_Homo sapiens_hsa046121.53693936
30Long-term potentiation_Homo sapiens_hsa047201.52804851
31African trypanosomiasis_Homo sapiens_hsa051431.50794806
32Renin secretion_Homo sapiens_hsa049241.47800544
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46999774
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37940038
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31559780
36Renin-angiotensin system_Homo sapiens_hsa046141.29870874
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.28893876
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27887995
39Gap junction_Homo sapiens_hsa045401.27360316
40Legionellosis_Homo sapiens_hsa051341.27028647
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26919089
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26484693
43Caffeine metabolism_Homo sapiens_hsa002321.26032986
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.25394775
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.24789724
46Primary immunodeficiency_Homo sapiens_hsa053401.17923338
47Cholinergic synapse_Homo sapiens_hsa047251.15416969
48Retinol metabolism_Homo sapiens_hsa008301.14889962
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.14471184
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13284205
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.13243993
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11910785
53Dopaminergic synapse_Homo sapiens_hsa047281.09368789
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06985249
55GnRH signaling pathway_Homo sapiens_hsa049121.06849147
56Phototransduction_Homo sapiens_hsa047441.06185270
57Nitrogen metabolism_Homo sapiens_hsa009101.04706309
58Base excision repair_Homo sapiens_hsa034101.04147437
59Calcium signaling pathway_Homo sapiens_hsa040201.03983141
60Dorso-ventral axis formation_Homo sapiens_hsa043201.03809802
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03387879
62Protein export_Homo sapiens_hsa030601.02959300
63Linoleic acid metabolism_Homo sapiens_hsa005911.02352024
64Synaptic vesicle cycle_Homo sapiens_hsa047211.02340322
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01929241
66Alzheimers disease_Homo sapiens_hsa050101.00158702
67Arginine biosynthesis_Homo sapiens_hsa002200.99430786
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99421129
69Ether lipid metabolism_Homo sapiens_hsa005650.98902936
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.97392701
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96571754
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96406787
73Gastric acid secretion_Homo sapiens_hsa049710.95632644
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93916838
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93188810
76Chemical carcinogenesis_Homo sapiens_hsa052040.92584104
77cAMP signaling pathway_Homo sapiens_hsa040240.92132260
78Leishmaniasis_Homo sapiens_hsa051400.92045935
79Insulin secretion_Homo sapiens_hsa049110.91659022
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.91186144
81MAPK signaling pathway_Homo sapiens_hsa040100.91042525
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90648131
83RNA polymerase_Homo sapiens_hsa030200.87664279
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87358201
85ErbB signaling pathway_Homo sapiens_hsa040120.85346883
86Asthma_Homo sapiens_hsa053100.84904352
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83696130
88Cocaine addiction_Homo sapiens_hsa050300.82762416
89Dilated cardiomyopathy_Homo sapiens_hsa054140.80747081
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.80564642
91Basal transcription factors_Homo sapiens_hsa030220.80316509
92TGF-beta signaling pathway_Homo sapiens_hsa043500.80082260
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79233034
94Ovarian steroidogenesis_Homo sapiens_hsa049130.79051485
95Melanogenesis_Homo sapiens_hsa049160.78977739
96Arginine and proline metabolism_Homo sapiens_hsa003300.72964819
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72125716
98Malaria_Homo sapiens_hsa051440.70528369
99Ras signaling pathway_Homo sapiens_hsa040140.70318337
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69099853
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68575396
102Choline metabolism in cancer_Homo sapiens_hsa052310.68389401
103Butanoate metabolism_Homo sapiens_hsa006500.68042514
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.67998156
105Non-homologous end-joining_Homo sapiens_hsa034500.67779804
106Influenza A_Homo sapiens_hsa051640.66776658
107Collecting duct acid secretion_Homo sapiens_hsa049660.64443159
108Rheumatoid arthritis_Homo sapiens_hsa053230.64335245
109Alcoholism_Homo sapiens_hsa050340.63259748
110Allograft rejection_Homo sapiens_hsa053300.62983051
111Rap1 signaling pathway_Homo sapiens_hsa040150.62340681
112Circadian rhythm_Homo sapiens_hsa047100.60848277
113Sphingolipid metabolism_Homo sapiens_hsa006000.60420326
114Hepatitis B_Homo sapiens_hsa051610.59923754
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59572516
116Olfactory transduction_Homo sapiens_hsa047400.58835951
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58590737
118Cardiac muscle contraction_Homo sapiens_hsa042600.58505384
119ABC transporters_Homo sapiens_hsa020100.57846275
120Estrogen signaling pathway_Homo sapiens_hsa049150.57794674
121HTLV-I infection_Homo sapiens_hsa051660.56275353
122Lysine degradation_Homo sapiens_hsa003100.56105361
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55140541
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54403541
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53450065
126Pancreatic secretion_Homo sapiens_hsa049720.53386116
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52996113
128mRNA surveillance pathway_Homo sapiens_hsa030150.52887872
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52254546
130VEGF signaling pathway_Homo sapiens_hsa043700.52043062
131Tight junction_Homo sapiens_hsa045300.51700852
132Sulfur relay system_Homo sapiens_hsa041220.51191482
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50683060
134Tuberculosis_Homo sapiens_hsa051520.50563664
135Complement and coagulation cascades_Homo sapiens_hsa046100.50274133
136Type II diabetes mellitus_Homo sapiens_hsa049300.49571988
137Glioma_Homo sapiens_hsa052140.48949051
138Osteoclast differentiation_Homo sapiens_hsa043800.48731290
139Pyrimidine metabolism_Homo sapiens_hsa002400.48415664
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47716770
141Platelet activation_Homo sapiens_hsa046110.47270056
142Wnt signaling pathway_Homo sapiens_hsa043100.47121799
143Hematopoietic cell lineage_Homo sapiens_hsa046400.46290345
144Hippo signaling pathway_Homo sapiens_hsa043900.44766900
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44703943
146B cell receptor signaling pathway_Homo sapiens_hsa046620.43852062
147Measles_Homo sapiens_hsa051620.42231775
148Adipocytokine signaling pathway_Homo sapiens_hsa049200.42198349
149N-Glycan biosynthesis_Homo sapiens_hsa005100.41156738
150Herpes simplex infection_Homo sapiens_hsa051680.39244667
151T cell receptor signaling pathway_Homo sapiens_hsa046600.39152228
152Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39024571
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38986432
154Phagosome_Homo sapiens_hsa041450.38869112
155Renal cell carcinoma_Homo sapiens_hsa052110.37885697
156Chemokine signaling pathway_Homo sapiens_hsa040620.37245231
157Fatty acid biosynthesis_Homo sapiens_hsa000610.37064101
158Oxidative phosphorylation_Homo sapiens_hsa001900.37021183
159Fatty acid degradation_Homo sapiens_hsa000710.36797371
160Systemic lupus erythematosus_Homo sapiens_hsa053220.36393416
161Inositol phosphate metabolism_Homo sapiens_hsa005620.35668679
162Autoimmune thyroid disease_Homo sapiens_hsa053200.32744414
163NF-kappa B signaling pathway_Homo sapiens_hsa040640.31894350
164Notch signaling pathway_Homo sapiens_hsa043300.31592247
165NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30534612
166Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29923593
167PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27595930
168Toxoplasmosis_Homo sapiens_hsa051450.23311217
169Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21177559
170Glycerophospholipid metabolism_Homo sapiens_hsa005640.20995392
171Hepatitis C_Homo sapiens_hsa051600.20991610
172Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19902309

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