MMP24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagenase). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.87640908
2synaptic vesicle maturation (GO:0016188)5.79398134
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.72671783
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.56920681
5vocalization behavior (GO:0071625)5.56062663
6fat-soluble vitamin catabolic process (GO:0042363)5.45102304
7vitamin catabolic process (GO:0009111)5.45102304
8layer formation in cerebral cortex (GO:0021819)5.34223123
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.30699407
10cellular response to vitamin D (GO:0071305)5.29899920
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.22431901
12cerebellar granule cell differentiation (GO:0021707)5.09751424
13neuron cell-cell adhesion (GO:0007158)5.00996723
14synaptic vesicle exocytosis (GO:0016079)4.96649101
15response to pheromone (GO:0019236)4.81625533
16regulation of synaptic vesicle exocytosis (GO:2000300)4.81186614
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.74999627
18exploration behavior (GO:0035640)4.73778463
19gamma-aminobutyric acid transport (GO:0015812)4.73175865
20protein localization to synapse (GO:0035418)4.71568999
21glutamate secretion (GO:0014047)4.65996116
22positive regulation of synapse maturation (GO:0090129)4.58865600
23regulation of glutamate receptor signaling pathway (GO:1900449)4.52048280
24pyrimidine nucleobase catabolic process (GO:0006208)4.44981386
25glutamate receptor signaling pathway (GO:0007215)4.44307738
26neurotransmitter secretion (GO:0007269)4.42017419
27neuronal action potential propagation (GO:0019227)4.38979796
28dendritic spine morphogenesis (GO:0060997)4.37888917
29dendrite morphogenesis (GO:0048813)4.32177277
30synaptic transmission, glutamatergic (GO:0035249)4.31705398
31regulation of synaptic vesicle transport (GO:1902803)4.17552781
32regulation of synapse structural plasticity (GO:0051823)4.05448994
33postsynaptic membrane organization (GO:0001941)4.03964103
34neuron recognition (GO:0008038)4.02081120
35regulation of long-term neuronal synaptic plasticity (GO:0048169)4.01508429
36neurotransmitter-gated ion channel clustering (GO:0072578)4.00223128
37cellular potassium ion homeostasis (GO:0030007)3.97139155
38cerebellar Purkinje cell differentiation (GO:0021702)3.89704969
39neuron-neuron synaptic transmission (GO:0007270)3.89359615
40long-term memory (GO:0007616)3.88745502
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.88440661
42cell migration in hindbrain (GO:0021535)3.88124312
43G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.86917844
44regulation of neuronal synaptic plasticity (GO:0048168)3.86665904
45axonal fasciculation (GO:0007413)3.83261955
46sodium ion export (GO:0071436)3.76234630
47positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.72075953
48cellular response to vitamin (GO:0071295)3.72065374
49transmission of nerve impulse (GO:0019226)3.71647920
50central nervous system projection neuron axonogenesis (GO:0021952)3.71251864
51proline transport (GO:0015824)3.69001038
52positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.63038100
53cell differentiation in hindbrain (GO:0021533)3.62819027
54positive regulation of membrane potential (GO:0045838)3.62668205
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.59016081
56negative regulation of microtubule polymerization (GO:0031115)3.58843873
57nucleobase catabolic process (GO:0046113)3.58597380
58auditory behavior (GO:0031223)3.58570177
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56492351
60neuromuscular process controlling balance (GO:0050885)3.55820114
61neurotransmitter transport (GO:0006836)3.54848389
62regulation of synapse maturation (GO:0090128)3.54635917
63presynaptic membrane organization (GO:0097090)3.54422934
64synapse assembly (GO:0007416)3.50259725
65membrane assembly (GO:0071709)3.48343990
66presynaptic membrane assembly (GO:0097105)3.41918185
67establishment of mitochondrion localization (GO:0051654)3.40194402
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39263200
69regulation of postsynaptic membrane potential (GO:0060078)3.38824162
70activation of protein kinase A activity (GO:0034199)3.36492364
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.34164178
72regulation of dendritic spine morphogenesis (GO:0061001)3.33939117
73cytoskeletal anchoring at plasma membrane (GO:0007016)3.33832584
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32812210
75regulation of neurotransmitter secretion (GO:0046928)3.31082066
76regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.29773499
77establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.29719145
78mitochondrion transport along microtubule (GO:0047497)3.29719145
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.29104832
80synaptic vesicle endocytosis (GO:0048488)3.28942376
81regulation of neurotransmitter levels (GO:0001505)3.28419710
82adult walking behavior (GO:0007628)3.24954360
83cerebellar Purkinje cell layer development (GO:0021680)3.24313448
84positive regulation of dendritic spine morphogenesis (GO:0061003)3.22020582
85neuronal ion channel clustering (GO:0045161)3.19064694
86positive regulation of synapse assembly (GO:0051965)3.18242396
87positive regulation of neurotransmitter transport (GO:0051590)3.18030362
88positive regulation of dendritic spine development (GO:0060999)3.17900304
89cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17558404
90amino acid import (GO:0043090)3.17247325
91cell communication by electrical coupling (GO:0010644)3.16022907
92negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15681053
93organelle transport along microtubule (GO:0072384)3.14159799
94regulation of vesicle fusion (GO:0031338)3.13767782
95positive regulation of neurotransmitter secretion (GO:0001956)3.12733123
96synapse organization (GO:0050808)3.11822639
97response to auditory stimulus (GO:0010996)3.10650575
98mechanosensory behavior (GO:0007638)3.08290701
99clathrin coat assembly (GO:0048268)3.08098346
100regulation of synaptic plasticity (GO:0048167)3.05674488
101regulation of synaptic transmission, glutamatergic (GO:0051966)3.05382897
102membrane depolarization (GO:0051899)3.04142427
103glycine transport (GO:0015816)3.02350425
104membrane depolarization during action potential (GO:0086010)3.01711241
105G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.00708644
106prepulse inhibition (GO:0060134)3.00371590
107regulation of neurotransmitter transport (GO:0051588)2.98890250
108axon cargo transport (GO:0008088)2.98456032
109mating behavior (GO:0007617)2.97549838
110vitamin D metabolic process (GO:0042359)2.97366976
111establishment of nucleus localization (GO:0040023)2.96693216
112intraspecies interaction between organisms (GO:0051703)2.95356001
113social behavior (GO:0035176)2.95356001
114membrane hyperpolarization (GO:0060081)2.95178268
115L-amino acid import (GO:0043092)2.88189843
116innervation (GO:0060384)2.82379526
117potassium ion homeostasis (GO:0055075)2.81260003
118axon extension (GO:0048675)2.77527979
119regulation of NFAT protein import into nucleus (GO:0051532)2.76624619
120neuromuscular process (GO:0050905)2.72167006
121inner ear receptor cell development (GO:0060119)2.70117080
122visual learning (GO:0008542)2.66502382

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.85518894
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19050221
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14223335
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13425943
5GBX2_23144817_ChIP-Seq_PC3_Human3.09620563
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.85254888
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83039045
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83039045
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67991552
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.64520725
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58138779
12DROSHA_22980978_ChIP-Seq_HELA_Human2.57605059
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57592460
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56366579
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53328239
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52527071
17* EZH2_27294783_Chip-Seq_ESCs_Mouse2.50096271
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34105254
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33737584
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.32512895
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.32425817
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.30338465
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.29658758
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20118816
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16120639
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11391252
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10206976
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07819440
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.06993922
30SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88176725
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85893328
32AR_21572438_ChIP-Seq_LNCaP_Human1.81967355
33ZNF274_21170338_ChIP-Seq_K562_Hela1.73544642
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68465709
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67119679
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.63724724
37SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56427942
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50625400
39EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49657814
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48932376
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48376881
42SMAD4_21799915_ChIP-Seq_A2780_Human1.45802615
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45045644
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.44150126
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.40464877
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34295245
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.33557809
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31895406
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.30946672
50TAF15_26573619_Chip-Seq_HEK293_Human1.30563713
51* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30357008
52KDM2B_26808549_Chip-Seq_K562_Human1.29128543
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28653850
54* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27253561
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27196766
56CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26693718
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25912329
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25444618
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.24417208
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23424187
61AR_19668381_ChIP-Seq_PC3_Human1.22613029
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21878309
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21180695
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19891757
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19693178
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19307131
67CTCF_27219007_Chip-Seq_Bcells_Human1.19288679
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18309191
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17087417
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.15946989
71* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15537942
72RNF2_27304074_Chip-Seq_NSC_Mouse1.14894902
73* STAT3_23295773_ChIP-Seq_U87_Human1.14271745
74AR_25329375_ChIP-Seq_VCAP_Human1.14261800
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13385118
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.12933143
77P300_19829295_ChIP-Seq_ESCs_Human1.12592333
78IGF1R_20145208_ChIP-Seq_DFB_Human1.11471810
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09746752
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08231503
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07799220
82LXR_22292898_ChIP-Seq_THP-1_Human1.06106205
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05700412
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04642886
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04492839
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04038733
87* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02409696
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.01263535
89TCF4_23295773_ChIP-Seq_U87_Human1.01184244
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00963177
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.00064154
92PIAS1_25552417_ChIP-Seq_VCAP_Human0.99910208
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.99844455
94ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99422818
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99419104
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.99195264
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97893184
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97893184
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97869330
100TP53_23651856_ChIP-Seq_MEFs_Mouse0.97065930
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95752375
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.95728793
103SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94889408
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94746898
105POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94280161
106NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94186994
107AHR_22903824_ChIP-Seq_MCF-7_Human0.93463435
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93377233
109RUNX2_22187159_ChIP-Seq_PCA_Human0.92690734
110TET1_21490601_ChIP-Seq_MESCs_Mouse0.92184528
111TP53_16413492_ChIP-PET_HCT116_Human0.91197090
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91022623
113RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90867329
114UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90826700
115RUNX1_26923725_Chip-Seq_HPCs_Mouse0.90713158
116* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90626482
117POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90482555
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89080975
119SMC4_20622854_ChIP-Seq_HELA_Human0.88590345
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88545634
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86633623
122ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85915006
123KDM2B_26808549_Chip-Seq_DND41_Human0.85448779
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85435446
125CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85101676
126PRDM14_20953172_ChIP-Seq_ESCs_Human0.84369597
127EP300_21415370_ChIP-Seq_HL-1_Mouse0.84246801
128TP53_20018659_ChIP-ChIP_R1E_Mouse0.83852896
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83576849
130POU5F1_16518401_ChIP-PET_MESCs_Mouse0.83350394
131KDM2B_26808549_Chip-Seq_JURKAT_Human0.82616262
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82578701
133TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.82485313
134POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.82333350
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.81808430
136SMAD4_21741376_ChIP-Seq_EPCs_Human0.80861298
137NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.79929803
138CREB1_26743006_Chip-Seq_LNCaP_Human0.79775805
139TBX3_20139965_ChIP-Seq_MESCs_Mouse0.78258796
140NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78124433
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77577432

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.99262989
2MP0003635_abnormal_synaptic_transmissio4.11007260
3MP0004270_analgesia4.03169631
4MP0003880_abnormal_central_pattern3.87414247
5MP0005423_abnormal_somatic_nervous3.70819056
6MP0009046_muscle_twitch3.54497286
7MP0002063_abnormal_learning/memory/cond3.20163626
8MP0009745_abnormal_behavioral_response3.17299459
9MP0002064_seizures2.96748675
10* MP0002734_abnormal_mechanical_nocicepti2.81575113
11* MP0002572_abnormal_emotion/affect_behav2.65009716
12MP0002272_abnormal_nervous_system2.58339088
13MP0002735_abnormal_chemical_nociception2.52300135
14MP0000778_abnormal_nervous_system2.51069905
15MP0001486_abnormal_startle_reflex2.47071688
16* MP0001968_abnormal_touch/_nociception2.44394451
17MP0002184_abnormal_innervation2.43249772
18MP0008569_lethality_at_weaning2.39800193
19MP0001440_abnormal_grooming_behavior2.38218357
20MP0003329_amyloid_beta_deposits2.17709121
21* MP0002067_abnormal_sensory_capabilities2.16305742
22* MP0002733_abnormal_thermal_nociception2.13095616
23* MP0001970_abnormal_pain_threshold1.98424453
24MP0002557_abnormal_social/conspecific_i1.93797968
25MP0004924_abnormal_behavior1.92634280
26MP0005386_behavior/neurological_phenoty1.92634280
27MP0004885_abnormal_endolymph1.92466559
28MP0004811_abnormal_neuron_physiology1.91521695
29MP0001501_abnormal_sleep_pattern1.87017337
30MP0009780_abnormal_chondrocyte_physiolo1.84491324
31MP0006276_abnormal_autonomic_nervous1.84272076
32MP0004858_abnormal_nervous_system1.84076550
33* MP0000955_abnormal_spinal_cord1.82011047
34MP0000537_abnormal_urethra_morphology1.71474279
35* MP0002882_abnormal_neuron_morphology1.59963517
36MP0005623_abnormal_meninges_morphology1.59546627
37MP0002909_abnormal_adrenal_gland1.59068969
38* MP0002066_abnormal_motor_capabilities/c1.56987429
39MP0004142_abnormal_muscle_tone1.54064844
40MP0004145_abnormal_muscle_electrophysio1.53593744
41MP0001984_abnormal_olfaction1.46682606
42* MP0002736_abnormal_nociception_after1.43635504
43MP0004742_abnormal_vestibular_system1.41552380
44MP0003879_abnormal_hair_cell1.38642328
45MP0002152_abnormal_brain_morphology1.38467733
46MP0003633_abnormal_nervous_system1.33155103
47MP0005645_abnormal_hypothalamus_physiol1.31125258
48MP0001188_hyperpigmentation1.29764368
49MP0001502_abnormal_circadian_rhythm1.25439430
50MP0003631_nervous_system_phenotype1.24339770
51MP0002822_catalepsy1.20322155
52MP0003632_abnormal_nervous_system1.18663098
53MP0000920_abnormal_myelination1.18205780
54MP0002229_neurodegeneration1.11530544
55MP0001905_abnormal_dopamine_level1.10047508
56MP0004133_heterotaxia1.06038744
57MP0003634_abnormal_glial_cell1.05696535
58MP0001348_abnormal_lacrimal_gland1.04908805
59MP0003942_abnormal_urinary_system1.04695410
60MP0000569_abnormal_digit_pigmentation1.02963556
61MP0003787_abnormal_imprinting1.02855500
62MP0000631_abnormal_neuroendocrine_gland1.01070731
63MP0001529_abnormal_vocalization1.00827961
64MP0000462_abnormal_digestive_system0.98522525
65MP0005187_abnormal_penis_morphology0.97776266
66MP0000534_abnormal_ureter_morphology0.97668946
67MP0002638_abnormal_pupillary_reflex0.95296031
68MP0002752_abnormal_somatic_nervous0.94739227
69MP0000604_amyloidosis0.94562632
70MP0005394_taste/olfaction_phenotype0.93935042
71MP0005499_abnormal_olfactory_system0.93935042
72MP0004019_abnormal_vitamin_homeostasis0.92934354
73MP0005551_abnormal_eye_electrophysiolog0.91977755
74MP0005646_abnormal_pituitary_gland0.91882889
75MP0001849_ear_inflammation0.91783768
76MP0002069_abnormal_eating/drinking_beha0.91612743
77MP0003690_abnormal_glial_cell0.90444801
78MP0001299_abnormal_eye_distance/0.89507409
79* MP0003861_abnormal_nervous_system0.88938568
80MP0003137_abnormal_impulse_conducting0.85497048
81MP0001963_abnormal_hearing_physiology0.84985801
82MP0000751_myopathy0.84630253
83MP0008872_abnormal_physiological_respon0.82916179
84MP0002081_perinatal_lethality0.81673453
85MP0002249_abnormal_larynx_morphology0.81275235
86MP0003122_maternal_imprinting0.80635579
87MP0003283_abnormal_digestive_organ0.80213948
88MP0001177_atelectasis0.79568454
89MP0000579_abnormal_nail_morphology0.79457372
90MP0003705_abnormal_hypodermis_morpholog0.78717671
91MP0003119_abnormal_digestive_system0.78640298
92MP0003123_paternal_imprinting0.78323945
93MP0006072_abnormal_retinal_apoptosis0.78191996
94MP0004085_abnormal_heartbeat0.77496379
95MP0003938_abnormal_ear_development0.73148733
96MP0000566_synostosis0.72936830
97MP0003121_genomic_imprinting0.69062242
98MP0003937_abnormal_limbs/digits/tail_de0.68273865
99MP0009672_abnormal_birth_weight0.67844084
100MP0001485_abnormal_pinna_reflex0.67550518
101MP0003115_abnormal_respiratory_system0.65851705
102MP0010769_abnormal_survival0.65812911
103MP0005409_darkened_coat_color0.65720193
104MP0004215_abnormal_myocardial_fiber0.65407173
105MP0000428_abnormal_craniofacial_morphol0.65109511
106MP0010770_preweaning_lethality0.63267068
107MP0002082_postnatal_lethality0.63267068
108MP0003091_abnormal_cell_migration0.62738865
109MP0000013_abnormal_adipose_tissue0.62006570
110MP0010768_mortality/aging0.61901288
111MP0004272_abnormal_basement_membrane0.61290062
112MP0008874_decreased_physiological_sensi0.60831184
113MP0005076_abnormal_cell_differentiation0.60573939
114MP0004233_abnormal_muscle_weight0.60508435
115MP0002139_abnormal_hepatobiliary_system0.60342454
116MP0001943_abnormal_respiration0.60320058
117MP0005535_abnormal_body_temperature0.60213250
118MP0002089_abnormal_postnatal_growth/wei0.56760538
119MP0010386_abnormal_urinary_bladder0.56156332
120MP0008961_abnormal_basal_metabolism0.55856426
121MP0009379_abnormal_foot_pigmentation0.55789283
122MP0002090_abnormal_vision0.55743015
123MP0003956_abnormal_body_size0.55086136
124MP0004043_abnormal_pH_regulation0.54239966
125MP0000026_abnormal_inner_ear0.54210542

Predicted human phenotypes

RankGene SetZ-score
1Elfin facies (HP:0004428)6.61934590
2Myokymia (HP:0002411)5.78373093
3Focal motor seizures (HP:0011153)5.34527409
4Visual hallucinations (HP:0002367)5.33422356
5Progressive cerebellar ataxia (HP:0002073)5.00819921
6Action tremor (HP:0002345)4.89412390
7Focal seizures (HP:0007359)4.87776606
8Epileptic encephalopathy (HP:0200134)4.24060088
9Mutism (HP:0002300)4.18444214
10Supranuclear gaze palsy (HP:0000605)4.12400517
11Broad-based gait (HP:0002136)3.97234623
12Turricephaly (HP:0000262)3.89449576
13Abnormality of the corticospinal tract (HP:0002492)3.81962461
14Atonic seizures (HP:0010819)3.79009066
15Gaze-evoked nystagmus (HP:0000640)3.65086034
16Amyotrophic lateral sclerosis (HP:0007354)3.59307210
17Ankle clonus (HP:0011448)3.53191025
18Febrile seizures (HP:0002373)3.52943284
19Absence seizures (HP:0002121)3.44792255
20Neurofibrillary tangles (HP:0002185)3.44204423
21Poor eye contact (HP:0000817)3.44131665
22Genetic anticipation (HP:0003743)3.35246489
23Bronchomalacia (HP:0002780)3.28971965
24Diplopia (HP:0000651)3.28391282
25Abnormality of binocular vision (HP:0011514)3.28391282
26Dysdiadochokinesis (HP:0002075)3.26623531
27Scanning speech (HP:0002168)3.18936025
28Hemiparesis (HP:0001269)3.17407635
29Dysmetria (HP:0001310)3.15876941
30Intention tremor (HP:0002080)3.14924036
31Cerebral inclusion bodies (HP:0100314)3.14855731
32Hypercalciuria (HP:0002150)3.10152219
33Generalized tonic-clonic seizures (HP:0002069)3.10041737
34Limb dystonia (HP:0002451)3.08996299
35Dialeptic seizures (HP:0011146)3.06605027
36Abnormal social behavior (HP:0012433)3.03938493
37Impaired social interactions (HP:0000735)3.03938493
38Truncal ataxia (HP:0002078)3.03835152
39Shallow orbits (HP:0000586)3.02569305
40Impaired smooth pursuit (HP:0007772)3.00623125
41Excessive salivation (HP:0003781)2.99892293
42Drooling (HP:0002307)2.99892293
43Depression (HP:0000716)2.96142857
44Spastic gait (HP:0002064)2.93730731
45Papilledema (HP:0001085)2.89723747
46Abnormal eating behavior (HP:0100738)2.88624673
47Agitation (HP:0000713)2.83517150
48Termporal pattern (HP:0011008)2.83243212
49Insidious onset (HP:0003587)2.83243212
50Urinary bladder sphincter dysfunction (HP:0002839)2.82152793
51Megalencephaly (HP:0001355)2.77692870
52Abnormality of ocular smooth pursuit (HP:0000617)2.73687480
53Impaired vibration sensation in the lower limbs (HP:0002166)2.73635997
54Anxiety (HP:0000739)2.71902280
55Obstructive sleep apnea (HP:0002870)2.69589231
56Progressive inability to walk (HP:0002505)2.68545506
57Akinesia (HP:0002304)2.68056719
58Morphological abnormality of the pyramidal tract (HP:0002062)2.67360434
59Hypercalcemia (HP:0003072)2.63876051
60Urinary urgency (HP:0000012)2.62579827
61Broad metatarsal (HP:0001783)2.61506807
62Abnormality of the lower motor neuron (HP:0002366)2.58920465
63Annular pancreas (HP:0001734)2.58759105
64Hemiplegia (HP:0002301)2.57483037
65Aplasia involving bones of the extremities (HP:0009825)2.53583782
66Aplasia involving bones of the upper limbs (HP:0009823)2.53583782
67Aplasia of the phalanges of the hand (HP:0009802)2.53583782
68Hyperventilation (HP:0002883)2.52835304
69Lower limb amyotrophy (HP:0007210)2.49716808
70Polyphagia (HP:0002591)2.48272382
71Dysmetric saccades (HP:0000641)2.46428688
72Inappropriate behavior (HP:0000719)2.45601574
73Stereotypic behavior (HP:0000733)2.44756869
74EEG with generalized epileptiform discharges (HP:0011198)2.39832210
75Epileptiform EEG discharges (HP:0011182)2.37307483
76Postural instability (HP:0002172)2.37059061
77Amblyopia (HP:0000646)2.36855607
78Hypsarrhythmia (HP:0002521)2.34008857
79Fetal akinesia sequence (HP:0001989)2.33834245
80Pheochromocytoma (HP:0002666)2.32219761
81Neuronal loss in central nervous system (HP:0002529)2.29673326
82Aqueductal stenosis (HP:0002410)2.28059913
83Hyperacusis (HP:0010780)2.27642613
84Apathy (HP:0000741)2.27106984
85Lower limb muscle weakness (HP:0007340)2.23918963
86Failure to thrive in infancy (HP:0001531)2.23861593
87Coronal craniosynostosis (HP:0004440)2.23649037
88Aortic valve stenosis (HP:0001650)2.19557429
89Torticollis (HP:0000473)2.18237375
90Absent speech (HP:0001344)2.17275163
91Choanal stenosis (HP:0000452)2.15558973
92Pulmonic stenosis (HP:0001642)2.13630144
93Bradykinesia (HP:0002067)2.13330795
94Synostosis involving the elbow (HP:0003938)2.12359099
95Humeroradial synostosis (HP:0003041)2.12359099
96Insomnia (HP:0100785)2.11017440
97Clonus (HP:0002169)2.09897538
98Degeneration of the lateral corticospinal tracts (HP:0002314)2.09404473
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09404473
100Postural tremor (HP:0002174)2.08642717
101Spastic tetraparesis (HP:0001285)2.07225909
102Focal dystonia (HP:0004373)2.04875975
103Diminished motivation (HP:0000745)2.01723821
104Hypoplasia of the brainstem (HP:0002365)2.00723885
105Aplasia/Hypoplasia of the brainstem (HP:0007362)2.00723885
106Lissencephaly (HP:0001339)1.99950942
107Gait ataxia (HP:0002066)1.98646153
108Inability to walk (HP:0002540)1.97715090
109Lower limb asymmetry (HP:0100559)1.96030975
110Status epilepticus (HP:0002133)1.94291203
111Ventricular fibrillation (HP:0001663)1.92896165
112Neuroendocrine neoplasm (HP:0100634)1.92713543
113Abnormality of saccadic eye movements (HP:0000570)1.92439906
114Polyuria (HP:0000103)1.91356054
115Sleep apnea (HP:0010535)1.91256956
116Tetraplegia (HP:0002445)1.90434129
117Abnormality of salivation (HP:0100755)1.89256142
118Generalized myoclonic seizures (HP:0002123)1.87008149
119Pointed chin (HP:0000307)1.85346382
120Pachygyria (HP:0001302)1.84977460
121Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84633478
122Psychosis (HP:0000709)1.84616308
123Craniofacial dystonia (HP:0012179)1.81461635
124Overriding aorta (HP:0002623)1.81060514
125Vitreoretinal degeneration (HP:0000655)1.79733282
126Ulnar bowing (HP:0003031)1.75857413
127Nephrocalcinosis (HP:0000121)1.75710988
128Hypoventilation (HP:0002791)1.73075877
129Trigonocephaly (HP:0000243)1.72371712
130Arnold-Chiari malformation (HP:0002308)1.68223703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.26238232
2MAP3K93.61889947
3NTRK33.54501992
4MAP3K42.88266801
5MINK12.84283782
6NTRK22.47843489
7PAK62.35965837
8MAP2K72.26547398
9DAPK22.00587089
10PHKG12.00185640
11PHKG22.00185640
12CAMKK11.95166232
13MAPK131.92636805
14EPHA41.88150302
15CAMKK21.83963159
16PNCK1.70598694
17NTRK11.69462454
18TNIK1.67319806
19MAP2K41.61659460
20CASK1.60202902
21DYRK21.51530360
22CDK51.51462457
23SIK21.49324042
24CDK191.46423917
25KSR21.41753320
26UHMK11.39201801
27KSR11.39149033
28PRPF4B1.34569034
29LATS21.33897386
30PDGFRA1.31729248
31PTK21.27365453
32PRKD31.22753488
33EEF2K1.21245235
34PRKCG1.19412226
35CSNK1G21.17882760
36RIPK11.16564944
37CDK121.14811351
38BMX1.13525628
39TYRO31.10248921
40STK111.09333314
41GRK51.08863201
42STK381.06887340
43ERBB41.04891246
44PLK21.03998376
45CDK151.03949084
46CDK181.01991951
47MARK21.01697177
48CDK141.00959014
49PKN11.00708432
50MAP3K121.00526264
51SCYL20.98926870
52ERBB30.98276882
53DYRK1A0.96773268
54ALK0.92994657
55CDK11A0.92462291
56RET0.92138680
57WNK10.91860897
58SGK2230.91343400
59SGK4940.91343400
60OXSR10.90295510
61CAMK2A0.85762378
62DAPK10.83588181
63PAK30.81370871
64MAP3K20.80600135
65CAMK2B0.78890633
66TAOK10.77748805
67CAMK10.75625461
68BRSK10.75201541
69PRKCH0.73897197
70RIPK40.73653794
71LIMK10.73165776
72FES0.70858707
73CSNK1G30.69528735
74CAMK1G0.69410211
75PRKCZ0.62924818
76MET0.62119873
77PRKD20.59322891
78DAPK30.58884378
79FYN0.57970576
80MAP3K100.57838319
81SGK20.57298462
82CSNK1A1L0.57101784
83PRKG20.55997162
84SGK10.54730431
85MTOR0.54170914
86PAK20.54077218
87STK390.53798559
88TTN0.53118106
89RPS6KA20.52781148
90MAPK120.50584235
91ROCK20.49819112
92FGFR20.49491212
93PRKCE0.49115960
94SGK30.48120396
95CAMK2G0.48045102
96CAMK2D0.46246872
97IRAK20.45338057
98RPS6KA30.44994790
99LMTK20.44340713
100MAP3K60.44243820
101PRKG10.43253602
102MAPKAPK50.42563598
103CSNK1D0.41049327
104EPHB20.40698806
105CDC42BPA0.39633111
106PDK10.39224636
107TESK10.38678326
108CAMK40.38489708
109BCR0.38341951
110PDPK10.38217835
111MAPK90.38193734
112WNK30.38147283
113RPS6KB10.38056011
114MAPK100.37304092
115PRKAA10.37143225
116CSNK1G10.33772280
117CAMK1D0.32330430
118FGFR40.32280335
119ICK0.32056694
120MAPK80.31206978
121ROCK10.30567942
122ARAF0.30279377
123HIPK20.30110516

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.79266418
2Synaptic vesicle cycle_Homo sapiens_hsa047212.99520506
3Glutamatergic synapse_Homo sapiens_hsa047242.77311807
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70984757
5GABAergic synapse_Homo sapiens_hsa047272.69691181
6Circadian entrainment_Homo sapiens_hsa047132.66462579
7Long-term potentiation_Homo sapiens_hsa047202.64386392
8Morphine addiction_Homo sapiens_hsa050322.40936154
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27197815
10Olfactory transduction_Homo sapiens_hsa047402.23154849
11Dopaminergic synapse_Homo sapiens_hsa047282.20898437
12Amphetamine addiction_Homo sapiens_hsa050312.15401778
13Long-term depression_Homo sapiens_hsa047302.13521594
14Salivary secretion_Homo sapiens_hsa049702.07017285
15Cholinergic synapse_Homo sapiens_hsa047251.96316364
16Taste transduction_Homo sapiens_hsa047421.89266012
17Gastric acid secretion_Homo sapiens_hsa049711.80054146
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79710243
19Insulin secretion_Homo sapiens_hsa049111.79421988
20Steroid biosynthesis_Homo sapiens_hsa001001.71514367
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68312757
22Serotonergic synapse_Homo sapiens_hsa047261.66966062
23Axon guidance_Homo sapiens_hsa043601.58338730
24Oxytocin signaling pathway_Homo sapiens_hsa049211.56405921
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55483950
26Cocaine addiction_Homo sapiens_hsa050301.54426189
27Renin secretion_Homo sapiens_hsa049241.54002431
28Vitamin B6 metabolism_Homo sapiens_hsa007501.51874432
29Gap junction_Homo sapiens_hsa045401.47317900
30GnRH signaling pathway_Homo sapiens_hsa049121.41073562
31Estrogen signaling pathway_Homo sapiens_hsa049151.37018688
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35761693
33Type II diabetes mellitus_Homo sapiens_hsa049301.35646576
34Calcium signaling pathway_Homo sapiens_hsa040201.33776789
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33170448
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25547997
37cAMP signaling pathway_Homo sapiens_hsa040241.20895509
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15921053
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15298139
40ErbB signaling pathway_Homo sapiens_hsa040121.13742623
41Glioma_Homo sapiens_hsa052141.11674183
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10675871
43Melanogenesis_Homo sapiens_hsa049161.04420413
44Hippo signaling pathway_Homo sapiens_hsa043901.00132981
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99332169
46Cardiac muscle contraction_Homo sapiens_hsa042600.98259199
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94017554
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.93873353
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.93232460
50Pancreatic secretion_Homo sapiens_hsa049720.93014872
51Tight junction_Homo sapiens_hsa045300.92422959
52Oocyte meiosis_Homo sapiens_hsa041140.91395456
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90449948
54Collecting duct acid secretion_Homo sapiens_hsa049660.90152497
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89845931
56Adherens junction_Homo sapiens_hsa045200.89461389
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87598392
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85230795
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84885192
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82879653
61Thyroid hormone synthesis_Homo sapiens_hsa049180.82672216
62Endometrial cancer_Homo sapiens_hsa052130.82243448
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81279748
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.81212024
65Renal cell carcinoma_Homo sapiens_hsa052110.79127289
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79020243
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.78536084
68Dorso-ventral axis formation_Homo sapiens_hsa043200.78068865
69Choline metabolism in cancer_Homo sapiens_hsa052310.76780743
70Phototransduction_Homo sapiens_hsa047440.72994873
71MAPK signaling pathway_Homo sapiens_hsa040100.72776463
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.71260149
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66431499
74VEGF signaling pathway_Homo sapiens_hsa043700.66187939
75Vibrio cholerae infection_Homo sapiens_hsa051100.64460381
76Alcoholism_Homo sapiens_hsa050340.62916332
77Dilated cardiomyopathy_Homo sapiens_hsa054140.62903841
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62099483
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61553468
80MicroRNAs in cancer_Homo sapiens_hsa052060.61222022
81Colorectal cancer_Homo sapiens_hsa052100.59331679
82Ras signaling pathway_Homo sapiens_hsa040140.58982369
83AMPK signaling pathway_Homo sapiens_hsa041520.58459051
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57657340
85mTOR signaling pathway_Homo sapiens_hsa041500.57150030
86Focal adhesion_Homo sapiens_hsa045100.56029719
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55650563
88Basal cell carcinoma_Homo sapiens_hsa052170.54782198
89Endocytosis_Homo sapiens_hsa041440.54077385
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53610243
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53182373
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51685088
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51159639
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50999676
95Rap1 signaling pathway_Homo sapiens_hsa040150.48953684
96Bile secretion_Homo sapiens_hsa049760.48842505
97Wnt signaling pathway_Homo sapiens_hsa043100.48718434
98Proteoglycans in cancer_Homo sapiens_hsa052050.47263158
99Non-small cell lung cancer_Homo sapiens_hsa052230.45915884
100Inositol phosphate metabolism_Homo sapiens_hsa005620.44769038
101Alzheimers disease_Homo sapiens_hsa050100.43612731
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43357465
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42534397
104Melanoma_Homo sapiens_hsa052180.41137740
105Glucagon signaling pathway_Homo sapiens_hsa049220.40507917
106Insulin signaling pathway_Homo sapiens_hsa049100.40386749
107ECM-receptor interaction_Homo sapiens_hsa045120.40023980
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39801269
109Butanoate metabolism_Homo sapiens_hsa006500.39377123
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38600664
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38068244
112Lysine degradation_Homo sapiens_hsa003100.35941843
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35931178
114Chemokine signaling pathway_Homo sapiens_hsa040620.35919362
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35549955
116Hedgehog signaling pathway_Homo sapiens_hsa043400.35529251
117Ovarian steroidogenesis_Homo sapiens_hsa049130.35484246
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35290908
119Prion diseases_Homo sapiens_hsa050200.34342489
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33165559
121Circadian rhythm_Homo sapiens_hsa047100.30934282

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