ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	adhesion of symbiont to host cell (GO:0044650)	3.94981627
2	virion attachment to host cell (GO:0019062)	3.94981627
3	adhesion of symbiont to host (GO:0044406)	3.34682685
4	positive regulation of triglyceride biosynthetic process (GO:0010867)	3.32439027
5	behavioral response to nicotine (GO:0035095)	2.82614708
6	regulation of autophagic vacuole assembly (GO:2000785)	2.69825681
7	tooth mineralization (GO:0034505)	2.69449200
8	cellular response to ATP (GO:0071318)	2.67713737
9	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.62781242
10	mannose metabolic process (GO:0006013)	2.57283167
11	regulation of triglyceride biosynthetic process (GO:0010866)	2.54936736
12	response to acidic pH (GO:0010447)	2.49414102
13	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.47362515
14	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.46365095
15	positive regulation of triglyceride metabolic process (GO:0090208)	2.45893754
16	regulation of glycogen (starch) synthase activity (GO:2000465)	2.44247338
17	cellular response to pH (GO:0071467)	2.43653814
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.40179091
19	regulation of vacuole organization (GO:0044088)	2.38566020
20	regulation of apoptotic process involved in morphogenesis (GO:1902337)	2.37890201
21	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	2.32767788
22	axoneme assembly (GO:0035082)	2.24466074
23	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.23637140
24	negative regulation of tumor necrosis factor production (GO:0032720)	2.22585861
25	urinary tract smooth muscle contraction (GO:0014848)	2.21584288
26	alanine transport (GO:0032328)	2.21095792
27	epithelial cilium movement (GO:0003351)	2.20237134
28	opioid receptor signaling pathway (GO:0038003)	2.18317149
29	motile cilium assembly (GO:0044458)	2.17365589
30	negative regulation of leukocyte chemotaxis (GO:0002689)	2.17167356
31	negative regulation of amino acid transport (GO:0051956)	2.16048861
32	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.14882674
33	negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)	2.14362813
34	positive regulation of CREB transcription factor activity (GO:0032793)	2.13984962
35	glycerophospholipid catabolic process (GO:0046475)	2.12255136
36	positive regulation of T cell apoptotic process (GO:0070234)	2.11724255
37	cell-cell junction maintenance (GO:0045217)	2.10798891
38	negative regulation of T cell differentiation in thymus (GO:0033085)	2.09894377
39	lytic vacuole organization (GO:0080171)	2.09776768
40	lysosome organization (GO:0007040)	2.09776768
41	potassium ion export (GO:0071435)	2.09192853
42	amine catabolic process (GO:0009310)	2.06306761
43	cellular biogenic amine catabolic process (GO:0042402)	2.06306761
44	negative regulation of mast cell activation (GO:0033004)	2.05150800
45	positive regulation of fatty acid oxidation (GO:0046321)	2.05025295
46	response to pH (GO:0009268)	2.04530755
47	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.03427752
48	negative regulation of cAMP-mediated signaling (GO:0043951)	2.01976203
49	axonemal dynein complex assembly (GO:0070286)	2.01614514
50	indole-containing compound catabolic process (GO:0042436)	2.01157083
51	indolalkylamine catabolic process (GO:0046218)	2.01157083
52	tryptophan catabolic process (GO:0006569)	2.01157083
53	membrane repolarization during action potential (GO:0086011)	2.00858984
54	regulation of hydrogen peroxide metabolic process (GO:0010310)	2.00602006
55	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	1.99819810
56	regulation of synaptic transmission, dopaminergic (GO:0032225)	1.99560068
57	response to dietary excess (GO:0002021)	1.99222204
58	regulation of short-term neuronal synaptic plasticity (GO:0048172)	1.98785761
59	positive regulation of protein dephosphorylation (GO:0035307)	1.96533652
60	low-density lipoprotein particle clearance (GO:0034383)	1.94198943
61	cellular response to exogenous dsRNA (GO:0071360)	1.93567852
62	regulation of sequestering of triglyceride (GO:0010889)	1.93375849
63	negative regulation of interleukin-1 production (GO:0032692)	1.91826037
64	pyrimidine-containing compound transmembrane transport (GO:0072531)	1.91605727
65	phagosome maturation (GO:0090382)	1.91152574
66	synaptic vesicle exocytosis (GO:0016079)	1.90961185
67	type B pancreatic cell proliferation (GO:0044342)	1.89957023
68	synaptic vesicle maturation (GO:0016188)	1.88307647
69	serotonin metabolic process (GO:0042428)	1.87554186
70	negative regulation of nitric oxide biosynthetic process (GO:0045019)	1.87540987
71	positive regulation of histone deacetylation (GO:0031065)	1.86432505
72	arginine catabolic process (GO:0006527)	1.86225481
73	positive regulation of protein kinase C signaling (GO:0090037)	1.85904863
74	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	1.85825225
75	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	1.85158689
76	kynurenine metabolic process (GO:0070189)	1.84269136
77	positive regulation of action potential (GO:0045760)	1.83798669
78	phenol-containing compound catabolic process (GO:0019336)	1.83021019
79	synaptic vesicle docking involved in exocytosis (GO:0016081)	1.82942789
80	hydrogen peroxide biosynthetic process (GO:0050665)	1.80963205
81	cellular response to zinc ion (GO:0071294)	1.80900608
82	glutamate secretion (GO:0014047)	1.80744486
83	negative regulation of interleukin-6 production (GO:0032715)	1.79871902
84	protein heterotrimerization (GO:0070208)	1.79016577
85	regulation of triglyceride metabolic process (GO:0090207)	1.78248449
86	positive regulation of defense response to virus by host (GO:0002230)	1.77722779
87	primary amino compound metabolic process (GO:1901160)	1.77591761
88	cilium movement (GO:0003341)	1.77466320
89	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	1.76261833
90	cellular response to nutrient (GO:0031670)	1.76027868
91	adaptation of signaling pathway (GO:0023058)	1.75856252
92	positive regulation of heat generation (GO:0031652)	1.75150449
93	regulation of sensory perception (GO:0051931)	1.75133931
94	regulation of sensory perception of pain (GO:0051930)	1.75133931
95	phosphatidylinositol acyl-chain remodeling (GO:0036149)	1.75085273
96	regulation of chemokine biosynthetic process (GO:0045073)	1.74954575
97	modulation by symbiont of host defense response (GO:0052031)	1.73594770
98	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	1.73594770
99	positive regulation by organism of defense response of other organism involved in symbiotic interact	1.73594770
100	modulation by symbiont of host immune response (GO:0052553)	1.73594770

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.86953496
2	LXR_22292898_ChIP-Seq_THP-1_Human	2.42098627
3	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.29630564
4	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.11679724
5	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.08551270
6	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.93334712
7	DROSHA_22980978_ChIP-Seq_HELA_Human	1.91376945
8	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.90943629
9	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.87131582
10	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.86580256
11	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.85482571
12	P68_20966046_ChIP-Seq_HELA_Human	1.80313563
13	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.79868572
14	CTCF_27219007_Chip-Seq_Bcells_Human	1.77825665
15	EZH2_22144423_ChIP-Seq_EOC_Human	1.70982366
16	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.69237966
17	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.68540891
18	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.63140647
19	VDR_21846776_ChIP-Seq_THP-1_Human	1.62317410
20	BCL6_27268052_Chip-Seq_Bcells_Human	1.61837738
21	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.56549214
22	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.56100241
23	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.56072965
24	BCOR_27268052_Chip-Seq_Bcells_Human	1.54173364
25	CTCF_20526341_ChIP-Seq_ESCs_Human	1.53932839
26	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.52479677
27	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.52006146
28	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.51699593
29	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.51646848
30	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.51054815
31	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.50065216
32	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.47612174
33	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.46872818
34	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.46859074
35	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.44867804
36	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.44649929
37	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.44448560
38	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.43871825
39	E2F1_20622854_ChIP-Seq_HELA_Human	1.42460258
40	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.42332514
41	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.42332514
42	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.41455084
43	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.41374957
44	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.41236735
45	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.40624507
46	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.39488971
47	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.39392066
48	KDM2B_26808549_Chip-Seq_K562_Human	1.37402927
49	RACK7_27058665_Chip-Seq_MCF-7_Human	1.36820703
50	STAT1_20625510_ChIP-Seq_HELA_Human	1.36033183
51	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.35905630
52	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.34031368
53	PHF8_20622854_ChIP-Seq_HELA_Human	1.32926187
54	SA1_27219007_Chip-Seq_Bcells_Human	1.31831138
55	REST_21632747_ChIP-Seq_MESCs_Mouse	1.31202198
56	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.30993158
57	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.29339917
58	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.28189813
59	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.28108749
60	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.27017878
61	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.26244137
62	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.25977320
63	SMC4_20622854_ChIP-Seq_HELA_Human	1.25816558
64	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.25493915
65	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.25478112
66	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.23493248
67	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.22889087
68	ERA_21632823_ChIP-Seq_H3396_Human	1.22555938
69	TP63_22573176_ChIP-Seq_HFKS_Human	1.21435047
70	KDM2B_26808549_Chip-Seq_DND41_Human	1.17688917
71	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.16868685
72	OCT4_19829295_ChIP-Seq_ESCs_Human	1.15817430
73	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.15369646
74	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.14697727
75	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.13660366
76	TP53_22127205_ChIP-Seq_IMR90_Human	1.12814212
77	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.10038730
78	VDR_24763502_ChIP-Seq_THP-1_Human	1.09850712
79	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.09227195
80	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.08261693
81	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.08112164
82	KLF4_19829295_ChIP-Seq_ESCs_Human	1.07747700
83	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.06290216
84	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.04827400
85	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.04599904
86	TAF2_19829295_ChIP-Seq_ESCs_Human	1.04202166
87	CREB1_26743006_Chip-Seq_LNCaP_Human	1.03026246
88	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.02654528
89	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.02435418
90	P300_27268052_Chip-Seq_Bcells_Human	1.00529525
91	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.97622702
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97476479
93	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.96497412
94	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.95773741
95	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.95555540
96	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.95226296
97	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.94507917
98	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.92078590
99	OCT4_20526341_ChIP-Seq_ESCs_Human	0.90876246
100	RAC3_21632823_ChIP-Seq_H3396_Human	0.89694762

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009840_abnormal_foam_cell	2.54468124
2	MP0003879_abnormal_hair_cell	2.30141639
3	MP0005058_abnormal_lysosome_morphology	2.27782009
4	MP0001968_abnormal_touch/_nociception	2.09924482
5	MP0001501_abnormal_sleep_pattern	1.89325432
6	MP0002733_abnormal_thermal_nociception	1.89265157
7	MP0001970_abnormal_pain_threshold	1.87528006
8	MP0004130_abnormal_muscle_cell	1.84903427
9	MP0004510_myositis	1.82414990
10	MP0009745_abnormal_behavioral_response	1.65820320
11	MP0003172_abnormal_lysosome_physiology	1.65713169
12	MP0002653_abnormal_ependyma_morphology	1.64155791
13	MP0002876_abnormal_thyroid_physiology	1.63895720
14	MP0002064_seizures	1.60602755
15	MP0002148_abnormal_hypersensitivity_rea	1.59956458
16	MP0001542_abnormal_bone_strength	1.58864402
17	MP0001905_abnormal_dopamine_level	1.57567974
18	MP0004859_abnormal_synaptic_plasticity	1.56263026
19	MP0001986_abnormal_taste_sensitivity	1.53184398
20	MP0008875_abnormal_xenobiotic_pharmacok	1.52873609
21	MP0003436_decreased_susceptibility_to	1.51968205
22	MP0002736_abnormal_nociception_after	1.49272207
23	MP0002277_abnormal_respiratory_mucosa	1.48478348
24	MP0003724_increased_susceptibility_to	1.47364267
25	MP0002735_abnormal_chemical_nociception	1.47241493
26	MP0003279_aneurysm	1.45660793
27	MP0010386_abnormal_urinary_bladder	1.40464393
28	MP0003635_abnormal_synaptic_transmissio	1.40321867
29	MP0003806_abnormal_nucleotide_metabolis	1.38642410
30	MP0003303_peritoneal_inflammation	1.36430390
31	MP0003075_altered_response_to	1.35154642
32	MP0009379_abnormal_foot_pigmentation	1.33008618
33	MP0002272_abnormal_nervous_system	1.32400590
34	MP0002572_abnormal_emotion/affect_behav	1.32141966
35	MP0001533_abnormal_skeleton_physiology	1.31688497
36	MP0009764_decreased_sensitivity_to	1.31632001
37	MP0003329_amyloid_beta_deposits	1.31599304
38	MP0000343_altered_response_to	1.29663252
39	MP0002063_abnormal_learning/memory/cond	1.29166633
40	MP0006082_CNS_inflammation	1.27867448
41	MP0004043_abnormal_pH_regulation	1.27833215
42	MP0005503_abnormal_tendon_morphology	1.25779170
43	MP0005595_abnormal_vascular_smooth	1.25304047
44	MP0004885_abnormal_endolymph	1.24392546
45	MP0005423_abnormal_somatic_nervous	1.22083800
46	MP0005377_hearing/vestibular/ear_phenot	1.21248192
47	MP0003878_abnormal_ear_physiology	1.21248192
48	MP0004858_abnormal_nervous_system	1.17384000
49	MP0001663_abnormal_digestive_system	1.17260581
50	MP0009046_muscle_twitch	1.15613967
51	MP0002734_abnormal_mechanical_nocicepti	1.13646983
52	MP0005535_abnormal_body_temperature	1.13073712
53	MP0001440_abnormal_grooming_behavior	1.10303233
54	MP0000230_abnormal_systemic_arterial	1.08691467
55	MP0009785_altered_susceptibility_to	1.06686233
56	MP0002139_abnormal_hepatobiliary_system	1.06072193
57	MP0003011_delayed_dark_adaptation	1.04103136
58	MP0001765_abnormal_ion_homeostasis	1.02736981
59	MP0005551_abnormal_eye_electrophysiolog	1.01719009
60	MP0005167_abnormal_blood-brain_barrier	1.00836394
61	MP0003787_abnormal_imprinting	1.00321485
62	MP0001502_abnormal_circadian_rhythm	1.00016297
63	MP0005670_abnormal_white_adipose	0.99852791
64	MP0004019_abnormal_vitamin_homeostasis	0.99389407
65	MP0001958_emphysema	0.99079611
66	MP0000604_amyloidosis	0.98708919
67	MP0002295_abnormal_pulmonary_circulatio	0.97546587
68	MP0002557_abnormal_social/conspecific_i	0.96856080
69	MP0005390_skeleton_phenotype	0.96000216
70	MP0005174_abnormal_tail_pigmentation	0.93985098
71	MP0001756_abnormal_urination	0.92628169
72	MP0000681_abnormal_thyroid_gland	0.90646068
73	MP0008438_abnormal_cutaneous_collagen	0.90198659
74	MP0005381_digestive/alimentary_phenotyp	0.89616800
75	MP0009780_abnormal_chondrocyte_physiolo	0.87274157
76	MP0002163_abnormal_gland_morphology	0.86634510
77	MP0005623_abnormal_meninges_morphology	0.86221548
78	MP0001790_abnormal_immune_system	0.85965422
79	MP0005387_immune_system_phenotype	0.85965422
80	MP0003123_paternal_imprinting	0.85267378
81	MP0000750_abnormal_muscle_regeneration	0.85055928
82	MP0005025_abnormal_response_to	0.84451337
83	MP0005448_abnormal_energy_balance	0.83436329
84	MP0001919_abnormal_reproductive_system	0.83282694
85	MP0003186_abnormal_redox_activity	0.83111341
86	MP0005379_endocrine/exocrine_gland_phen	0.82204069
87	MP0002419_abnormal_innate_immunity	0.81604808
88	MP0000538_abnormal_urinary_bladder	0.81528459
89	MP0008872_abnormal_physiological_respon	0.78741701
90	MP0003045_fibrosis	0.78174637
91	MP0000015_abnormal_ear_pigmentation	0.76692751
92	MP0002067_abnormal_sensory_capabilities	0.76469217
93	MP0008874_decreased_physiological_sensi	0.76427326
94	MP0004133_heterotaxia	0.76349368
95	MP0001486_abnormal_startle_reflex	0.75948348
96	MP0001664_abnormal_digestion	0.75742445
97	MP0005166_decreased_susceptibility_to	0.75517402
98	MP0000678_abnormal_parathyroid_gland	0.75485253
99	MP0000013_abnormal_adipose_tissue	0.75449203
100	MP0003633_abnormal_nervous_system	0.75013971

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of liposaccharide metabolism (HP:0010968)	4.27774539
2	Abnormality of glycosphingolipid metabolism (HP:0004343)	4.27774539
3	Abnormality of glycolipid metabolism (HP:0010969)	4.27774539
4	Dysostosis multiplex (HP:0000943)	3.25634081
5	Abnormality of polysaccharide metabolism (HP:0011012)	3.16846368
6	Abnormality of glycosaminoglycan metabolism (HP:0004371)	3.16846368
7	Abnormality of mucopolysaccharide metabolism (HP:0011020)	3.16846368
8	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.15562831
9	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.13528499
10	Congenital stationary night blindness (HP:0007642)	3.00531052
11	Increased cerebral lipofuscin (HP:0011813)	2.99632444
12	Type II lissencephaly (HP:0007260)	2.98218872
13	Absent/shortened dynein arms (HP:0200106)	2.89686580
14	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.89686580
15	Abnormal respiratory motile cilium morphology (HP:0005938)	2.85713801
16	Abnormal respiratory epithelium morphology (HP:0012253)	2.85713801
17	Vacuolated lymphocytes (HP:0001922)	2.82906915
18	Elevated erythrocyte sedimentation rate (HP:0003565)	2.81486170
19	Mesangial abnormality (HP:0001966)	2.79832428
20	Mucopolysacchariduria (HP:0008155)	2.78849981
21	Urinary glycosaminoglycan excretion (HP:0003541)	2.78849981
22	Mutism (HP:0002300)	2.70754610
23	Retinal atrophy (HP:0001105)	2.52419157
24	Polyphagia (HP:0002591)	2.49010763
25	Abnormality of the nasal mucosa (HP:0000433)	2.46972873
26	Hyperthyroidism (HP:0000836)	2.42978868
27	Visual hallucinations (HP:0002367)	2.41634223
28	Abnormality of midbrain morphology (HP:0002418)	2.39498901
29	Molar tooth sign on MRI (HP:0002419)	2.39498901
30	Abnormal ciliary motility (HP:0012262)	2.37564570
31	Myokymia (HP:0002411)	2.36687020
32	Abnormal eating behavior (HP:0100738)	2.31400104
33	Decreased circulating renin level (HP:0003351)	2.30920586
34	Prolonged neonatal jaundice (HP:0006579)	2.29016193
35	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.27274210
36	Diplopia (HP:0000651)	2.21089126
37	Abnormality of binocular vision (HP:0011514)	2.21089126
38	Nasal polyposis (HP:0100582)	2.20253565
39	Congenital sensorineural hearing impairment (HP:0008527)	2.18764879
40	Polydipsia (HP:0001959)	2.13660079
41	Abnormal drinking behavior (HP:0030082)	2.13660079
42	Pancreatic fibrosis (HP:0100732)	2.10191074
43	Prolonged QT interval (HP:0001657)	2.09046416
44	Joint stiffness (HP:0001387)	1.98747632
45	Follicular hyperkeratosis (HP:0007502)	1.98373775
46	Supranuclear gaze palsy (HP:0000605)	1.98193172
47	Abnormal EKG (HP:0003115)	1.96508009
48	Abnormal respiratory motile cilium physiology (HP:0012261)	1.90157317
49	Clumsiness (HP:0002312)	1.90141549
50	Axonal loss (HP:0003447)	1.89573796
51	Peritonitis (HP:0002586)	1.87918724
52	Neurofibrillary tangles (HP:0002185)	1.86103612
53	Absent speech (HP:0001344)	1.85420873
54	Genu recurvatum (HP:0002816)	1.84205570
55	Abnormal rod and cone electroretinograms (HP:0008323)	1.83587263
56	Agitation (HP:0000713)	1.83078092
57	Ventricular fibrillation (HP:0001663)	1.82967024
58	Abnormality of magnesium homeostasis (HP:0004921)	1.81757240
59	Pancreatic cysts (HP:0001737)	1.80730892
60	Hyperparathyroidism (HP:0000843)	1.80535459
61	Cystic liver disease (HP:0006706)	1.78758037
62	Craniofacial dystonia (HP:0012179)	1.78490876
63	Petechiae (HP:0000967)	1.78274493
64	Myositis (HP:0100614)	1.77949104
65	Akinesia (HP:0002304)	1.75531123
66	Ileus (HP:0002595)	1.75525471
67	Bulbous nose (HP:0000414)	1.75514228
68	Focal dystonia (HP:0004373)	1.74556546
69	Retinal dysplasia (HP:0007973)	1.72612866
70	Hypoventilation (HP:0002791)	1.71978075
71	Purpura (HP:0000979)	1.69296129
72	Abnormality of macrophages (HP:0004311)	1.68750531
73	Nephronophthisis (HP:0000090)	1.68694834
74	Stomatitis (HP:0010280)	1.67499160
75	Thin bony cortex (HP:0002753)	1.66736521
76	Hydroxyprolinuria (HP:0003080)	1.66201964
77	Abnormality of proline metabolism (HP:0010907)	1.66201964
78	Severe muscular hypotonia (HP:0006829)	1.66168313
79	Decreased central vision (HP:0007663)	1.65624482
80	Orchitis (HP:0100796)	1.64458865
81	Buphthalmos (HP:0000557)	1.63746417
82	Delusions (HP:0000746)	1.63291816
83	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.62960330
84	Breast hypoplasia (HP:0003187)	1.62251686
85	Broad metatarsal (HP:0001783)	1.61770847
86	Protruding tongue (HP:0010808)	1.61181488
87	Cerebellar dysplasia (HP:0007033)	1.60242721
88	Torticollis (HP:0000473)	1.59169730
89	Nuclear cataract (HP:0100018)	1.59145569
90	Systemic lupus erythematosus (HP:0002725)	1.59103320
91	Protrusio acetabuli (HP:0003179)	1.59037665
92	Abnormal hemoglobin (HP:0011902)	1.58670592
93	Acne (HP:0001061)	1.58636661
94	Intellectual disability, progressive (HP:0006887)	1.58066855
95	Bone cyst (HP:0012062)	1.58042853
96	Dementia (HP:0000726)	1.57779523
97	Increased corneal curvature (HP:0100692)	1.57403454
98	Keratoconus (HP:0000563)	1.57403454
99	Congenital glaucoma (HP:0001087)	1.56823622
100	Concave nail (HP:0001598)	1.56540713

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	2.58089985
2	ADRBK2	2.57252696
3	MAP3K11	2.32400039
4	PINK1	2.07107660
5	DAPK2	1.97082520
6	SIK2	1.95312166
7	LIMK1	1.78729754
8	TRIB3	1.73725151
9	MAPK15	1.65538344
10	SIK1	1.61707962
11	ABL2	1.59913367
12	MAP3K13	1.55462514
13	PRKD3	1.53409964
14	IRAK3	1.53198101
15	TLK1	1.53079971
16	EPHB2	1.52032975
17	PRKD2	1.50991372
18	TESK1	1.50161998
19	GRK1	1.49659086
20	GRK7	1.37981475
21	FRK	1.34563340
22	GRK5	1.34335673
23	ADRBK1	1.33410652
24	MAPKAPK3	1.26493689
25	MYLK	1.24772341
26	WNK4	1.24175715
27	CAMKK1	1.24109294
28	MARK1	1.22420865
29	TAOK1	1.19507285
30	CDC42BPA	1.18542257
31	PTK2B	1.16216830
32	MARK2	1.13854706
33	IRAK4	1.12253074
34	STK38	1.11423250
35	MARK3	1.10448963
36	NME2	1.10038225
37	CDK19	1.09110312
38	IKBKB	1.07643422
39	TNK2	1.07171612
40	MAP3K3	1.06537355
41	DDR2	1.04887332
42	IRAK2	1.04370535
43	MAP2K6	1.01709879
44	ACVR1B	1.01277810
45	CAMKK2	1.00770564
46	MAP2K3	0.99550045
47	GRK6	0.98852402
48	TBK1	0.97896772
49	PDPK1	0.96658231
50	TGFBR2	0.96259116
51	MAP4K1	0.94821572
52	ARAF	0.94628787
53	PRKG2	0.92703069
54	MAPK13	0.91816031
55	RIPK4	0.91009886
56	CAMK1	0.90910663
57	TAOK2	0.90097080
58	HIPK2	0.90018777
59	TAOK3	0.87962885
60	MAPK12	0.87735759
61	RPS6KA2	0.87298236
62	PAK6	0.87048089
63	PIM2	0.79215353
64	MAP2K2	0.78067276
65	DAPK3	0.76525882
66	MAP3K1	0.76139848
67	RIPK1	0.75705499
68	PRKCH	0.75549045
69	ZAP70	0.73670296
70	STK11	0.72748871
71	MOS	0.72221771
72	LMTK2	0.71476938
73	PHKG1	0.70019518
74	PHKG2	0.70019518
75	RPS6KA6	0.67649106
76	PDK1	0.65773727
77	NTRK3	0.63902221
78	TYRO3	0.63855033
79	ILK	0.63720746
80	CHUK	0.62820745
81	PRKCG	0.61493307
82	BRAF	0.57391817
83	MAP3K9	0.56807933
84	PKN1	0.54737779
85	PRKCQ	0.54149527
86	PRKCZ	0.54020621
87	PAK3	0.53017184
88	MATK	0.49659560
89	EPHB1	0.49275360
90	DYRK2	0.48232942
91	RPS6KC1	0.47576258
92	RPS6KL1	0.47576258
93	KIT	0.46435648
94	NTRK2	0.46252645
95	SGK494	0.46173439
96	SGK223	0.46173439
97	PRKCD	0.41506055
98	CDK5	0.41150636
99	MAP2K1	0.41135975
100	PTK2	0.40547053

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.84105593
2	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.28778029
3	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.19502070
4	Sulfur relay system_Homo sapiens_hsa04122	1.96600792
5	Lysosome_Homo sapiens_hsa04142	1.76996573
6	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.72066018
7	Other glycan degradation_Homo sapiens_hsa00511	1.68783478
8	Collecting duct acid secretion_Homo sapiens_hsa04966	1.66014857
9	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.54513486
10	Cocaine addiction_Homo sapiens_hsa05030	1.34088496
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.33988302
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.32667011
13	Morphine addiction_Homo sapiens_hsa05032	1.31291670
14	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.25092763
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.24154485
16	Nicotine addiction_Homo sapiens_hsa05033	1.22807300
17	Insulin secretion_Homo sapiens_hsa04911	1.14091975
18	Phototransduction_Homo sapiens_hsa04744	1.12615209
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.12299575
20	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.09879353
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.09878704
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.07574311
23	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.07056090
24	Circadian entrainment_Homo sapiens_hsa04713	1.06843183
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.05847355
26	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.05011509
27	Osteoclast differentiation_Homo sapiens_hsa04380	1.04326063
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03836439
29	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.01673426
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.01135018
31	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.00808195
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.99034716
33	Glutamatergic synapse_Homo sapiens_hsa04724	0.98929603
34	Mineral absorption_Homo sapiens_hsa04978	0.97733688
35	Histidine metabolism_Homo sapiens_hsa00340	0.96334155
36	Tryptophan metabolism_Homo sapiens_hsa00380	0.94034946
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.93574108
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91678991
39	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.87364879
40	TNF signaling pathway_Homo sapiens_hsa04668	0.87040534
41	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.86899247
42	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.85435889
43	GABAergic synapse_Homo sapiens_hsa04727	0.85107821
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84979341
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.83938284
46	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.82714898
47	VEGF signaling pathway_Homo sapiens_hsa04370	0.81939976
48	Cholinergic synapse_Homo sapiens_hsa04725	0.79785310
49	Amphetamine addiction_Homo sapiens_hsa05031	0.79514116
50	Salivary secretion_Homo sapiens_hsa04970	0.76112781
51	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.75279031
52	Serotonergic synapse_Homo sapiens_hsa04726	0.75124402
53	Sulfur metabolism_Homo sapiens_hsa00920	0.75082127
54	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75042941
55	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.74173997
56	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.73624560
57	Sphingolipid metabolism_Homo sapiens_hsa00600	0.73315768
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.72615240
59	Malaria_Homo sapiens_hsa05144	0.72530582
60	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.72420589
61	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.72302710
62	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.70671578
63	Vibrio cholerae infection_Homo sapiens_hsa05110	0.70578644
64	PPAR signaling pathway_Homo sapiens_hsa03320	0.69485095
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.69327248
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68861196
67	Phenylalanine metabolism_Homo sapiens_hsa00360	0.67838780
68	MAPK signaling pathway_Homo sapiens_hsa04010	0.66593244
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66416358
70	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.65949124
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65629121
72	Phagosome_Homo sapiens_hsa04145	0.64440701
73	cAMP signaling pathway_Homo sapiens_hsa04024	0.64281671
74	Tuberculosis_Homo sapiens_hsa05152	0.63655581
75	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.62346604
76	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.61574725
77	Alzheimers disease_Homo sapiens_hsa05010	0.61162241
78	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.59745191
79	Gastric acid secretion_Homo sapiens_hsa04971	0.58020485
80	Endocytosis_Homo sapiens_hsa04144	0.57949275
81	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.57496435
82	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.56939777
83	Chemokine signaling pathway_Homo sapiens_hsa04062	0.56731381
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55799201
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.55311691
86	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.55130838
87	GnRH signaling pathway_Homo sapiens_hsa04912	0.55088321
88	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.54859742
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.54738257
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.54297166
91	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.53962745
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53004211
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.52766230
94	African trypanosomiasis_Homo sapiens_hsa05143	0.52238334
95	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.52157545
96	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.51384867
97	Pertussis_Homo sapiens_hsa05133	0.51185817
98	Asthma_Homo sapiens_hsa05310	0.50845765
99	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.50106981
100	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.49388935

MMP24-AS1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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