MMP25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.99746561
2neutrophil activation (GO:0042119)5.81589566
3granulocyte activation (GO:0036230)5.54917495
4regulation of activation of Janus kinase activity (GO:0010533)5.49000377
5regulation of dendritic cell antigen processing and presentation (GO:0002604)5.43540714
6detection of other organism (GO:0098543)5.42459975
7NIK/NF-kappaB signaling (GO:0038061)5.27733953
8detection of bacterium (GO:0016045)5.24801086
9response to peptidoglycan (GO:0032494)5.21823763
10macrophage activation involved in immune response (GO:0002281)5.08691158
11regulation of T-helper 1 cell differentiation (GO:0045625)4.96108604
12regulation of B cell receptor signaling pathway (GO:0050855)4.89902720
13response to interleukin-15 (GO:0070672)4.88661028
14detection of external biotic stimulus (GO:0098581)4.70358274
15negative regulation of lymphocyte mediated immunity (GO:0002707)4.67011841
16leukocyte aggregation (GO:0070486)4.65295366
17cellular response to interleukin-15 (GO:0071350)4.55448820
18detection of molecule of bacterial origin (GO:0032490)4.55360924
19regulation of T-helper 2 cell differentiation (GO:0045628)4.54586660
20positive regulation of antigen processing and presentation (GO:0002579)4.49336023
21positive regulation of T-helper cell differentiation (GO:0045624)4.48492854
22regulation of interferon-beta biosynthetic process (GO:0045357)4.42075831
23positive regulation of interleukin-12 production (GO:0032735)4.37983711
24positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.36762134
25negative regulation of interleukin-12 production (GO:0032695)4.36282155
26T-helper 1 type immune response (GO:0042088)4.35279157
27myeloid dendritic cell differentiation (GO:0043011)4.33360826
28negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.32459148
29positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.28877760
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.28297914
31respiratory burst (GO:0045730)4.27723022
32cellular extravasation (GO:0045123)4.17609982
33dendritic cell chemotaxis (GO:0002407)4.09250188
34detection of biotic stimulus (GO:0009595)4.08225762
35positive regulation of type 2 immune response (GO:0002830)4.07833707
36negative regulation of leukocyte mediated immunity (GO:0002704)4.07198930
37regulation of hypersensitivity (GO:0002883)4.04995482
38positive regulation of alpha-beta T cell proliferation (GO:0046641)3.98855142
39response to muramyl dipeptide (GO:0032495)3.98632714
40growth hormone receptor signaling pathway (GO:0060396)3.95632489
41natural killer cell mediated cytotoxicity (GO:0042267)3.94720184
42natural killer cell mediated immunity (GO:0002228)3.94720184
43myeloid dendritic cell activation (GO:0001773)3.94150798
44regulation of gamma-delta T cell activation (GO:0046643)3.92979940
45regulation of antigen processing and presentation (GO:0002577)3.92911527
46positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.92801452
47antigen processing and presentation of endogenous antigen (GO:0019883)3.89611749
48regulation of RIG-I signaling pathway (GO:0039535)3.88744099
49production of molecular mediator involved in inflammatory response (GO:0002532)3.87762763
50response to host (GO:0075136)3.86444960
51response to host defenses (GO:0052200)3.86444960
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.86444960
53microglial cell activation (GO:0001774)3.85713459
54regulation of memory T cell differentiation (GO:0043380)3.82403168
55regulation of alpha-beta T cell proliferation (GO:0046640)3.81104688
56regulation of mast cell degranulation (GO:0043304)3.80078443
57superoxide anion generation (GO:0042554)3.78163413
58myeloid cell activation involved in immune response (GO:0002275)3.76833467
59positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.74169901
60negative regulation of phagocytosis (GO:0050765)3.73023957
61dendritic cell migration (GO:0036336)3.71274337
62macrophage activation (GO:0042116)3.69303230
63regulation of interleukin-12 production (GO:0032655)3.65511716
64regulation of T-helper cell differentiation (GO:0045622)3.65154981
65leukocyte migration involved in inflammatory response (GO:0002523)3.60978369
66leukocyte mediated cytotoxicity (GO:0001909)3.60436842
67neutrophil mediated immunity (GO:0002446)3.59689275
68negative regulation of T cell mediated immunity (GO:0002710)3.59169022
69positive regulation of natural killer cell differentiation (GO:0032825)3.57125848
70regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.56017300
71regulation of myeloid leukocyte mediated immunity (GO:0002886)3.54528583
72negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.54510810
73positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.53288499
74antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.52666141
75antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.52666141
76T-helper cell differentiation (GO:0042093)3.50589780
77CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.50589780
78regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.50439842
79regulation of mast cell activation involved in immune response (GO:0033006)3.50197255
80germinal center formation (GO:0002467)3.49339385
81positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.48468103
82positive regulation of humoral immune response (GO:0002922)3.48361584
83negative regulation of T-helper cell differentiation (GO:0045623)3.48334346
84negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.48334346
85antigen processing and presentation via MHC class Ib (GO:0002475)3.48213491
86immunoglobulin mediated immune response (GO:0016064)3.48101891
87leukocyte degranulation (GO:0043299)3.45423697
88type I interferon signaling pathway (GO:0060337)3.45164608
89cellular response to type I interferon (GO:0071357)3.45164608
90regulation of gamma-delta T cell differentiation (GO:0045586)3.44442832
91negative regulation of cell killing (GO:0031342)3.44293945
92negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.44293945
93regulation of T cell tolerance induction (GO:0002664)3.44081556
94positive regulation of interleukin-17 production (GO:0032740)3.43451730
95myeloid leukocyte mediated immunity (GO:0002444)3.40723302
96dendritic cell differentiation (GO:0097028)3.40122858
97response to type I interferon (GO:0034340)3.38806969
98T cell activation involved in immune response (GO:0002286)3.37766840
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.36913127
100regulation of interleukin-12 biosynthetic process (GO:0045075)3.36218857
101regulation of leukocyte degranulation (GO:0043300)3.36095795
102response to fungus (GO:0009620)3.36015630
103positive regulation of interferon-alpha production (GO:0032727)3.35998111
104negative thymic T cell selection (GO:0045060)3.35610246
105cellular response to growth hormone stimulus (GO:0071378)3.34605350
106positive regulation of T cell cytokine production (GO:0002726)3.33662849
107interferon-gamma-mediated signaling pathway (GO:0060333)3.29671671
108B cell receptor signaling pathway (GO:0050853)3.28839173
109regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.28680225
110regulation of tolerance induction (GO:0002643)3.27712312
111regulation of immunoglobulin secretion (GO:0051023)3.26777699
112response to host immune response (GO:0052572)3.26484129
113response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.26484129
114positive regulation of T cell mediated cytotoxicity (GO:0001916)3.26472986
115positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.26447292
116regulation of mast cell activation (GO:0033003)3.24928605
117natural killer cell activation involved in immune response (GO:0002323)3.24109833
118regulation of T cell mediated cytotoxicity (GO:0001914)3.23938632
119regulation of interferon-alpha production (GO:0032647)3.21662329
120negative regulation of type 2 immune response (GO:0002829)3.20966535
121regulation of T-helper 1 type immune response (GO:0002825)3.20790471
122positive regulation of interleukin-2 production (GO:0032743)3.20575037
123eosinophil migration (GO:0072677)3.20481035
124negative regulation of interleukin-17 production (GO:0032700)3.19981335
125regulation of B cell differentiation (GO:0045577)3.19537680
126hydrogen peroxide biosynthetic process (GO:0050665)3.19162439
127defense response to protozoan (GO:0042832)3.18173867
128positive regulation of T-helper 1 type immune response (GO:0002827)3.17614450
129positive regulation of gamma-delta T cell activation (GO:0046645)3.17282866
130regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.16340942
131positive regulation of mast cell activation (GO:0033005)3.14916185
132negative regulation of alpha-beta T cell activation (GO:0046636)3.14760768
133lipopolysaccharide-mediated signaling pathway (GO:0031663)3.14699687
134neutrophil chemotaxis (GO:0030593)3.13156992
135positive regulation of interleukin-10 production (GO:0032733)3.12482579
136negative regulation of interleukin-6 production (GO:0032715)3.12326296
137regulation of natural killer cell mediated immunity (GO:0002715)3.11581308
138regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.11581308
139JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.10901837
140negative T cell selection (GO:0043383)3.08945197
141modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.08560331
142modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.08560331
143positive regulation by organism of defense response of other organism involved in symbiotic interact3.08560331
144modulation by symbiont of host immune response (GO:0052553)3.08560331
145positive regulation by symbiont of host defense response (GO:0052509)3.08560331
146modulation by symbiont of host defense response (GO:0052031)3.08560331
147B cell mediated immunity (GO:0019724)3.08504552
148positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.08108497
149alpha-beta T cell differentiation involved in immune response (GO:0002293)3.07849106
150alpha-beta T cell activation involved in immune response (GO:0002287)3.07849106
151T cell differentiation involved in immune response (GO:0002292)3.07849106
152negative regulation of innate immune response (GO:0045824)3.06394873
153response to interferon-alpha (GO:0035455)3.04069934
154negative regulation of cytokine production involved in immune response (GO:0002719)3.02825159
155regulation of regulated secretory pathway (GO:1903305)3.02181833
156neutrophil migration (GO:1990266)2.98175806
157negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.93243659
158regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.92174774
159negative regulation of erythrocyte differentiation (GO:0045647)2.91889584
160tolerance induction (GO:0002507)2.91781055

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.13988264
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.33630734
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.00775153
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.74808933
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.62476395
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.28309729
7IRF8_27001747_Chip-Seq_BMDM_Mouse4.11607964
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.91099589
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.55085205
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.54454068
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.52805098
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.52768796
13MYB_21317192_ChIP-Seq_ERMYB_Mouse3.50861336
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.49244702
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.18125763
16STAT4_19710469_ChIP-ChIP_TH1__Mouse3.17733165
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.12267875
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.94843773
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.82876658
20* SPI1_23547873_ChIP-Seq_NB4_Human2.36502615
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.26435415
22MYC_22102868_ChIP-Seq_BL_Human2.24475806
23BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05778690
24* MYB_26560356_Chip-Seq_TH2_Human2.02624660
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.01020443
26VDR_24787735_ChIP-Seq_THP-1_Human1.99880549
27* MAF_26560356_Chip-Seq_TH1_Human1.99179551
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93974426
29RUNX_20019798_ChIP-Seq_JUKART_Human1.92917777
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84191843
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77102868
32MYB_26560356_Chip-Seq_TH1_Human1.74592061
33PU_27001747_Chip-Seq_BMDM_Mouse1.68431987
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62974636
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.61793548
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59126701
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58449338
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57213379
39PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55543331
40SPI1_23127762_ChIP-Seq_K562_Human1.55474290
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55386810
42VDR_24763502_ChIP-Seq_THP-1_Human1.55357788
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51601575
44LXR_22292898_ChIP-Seq_THP-1_Human1.46686012
45VDR_21846776_ChIP-Seq_THP-1_Human1.44265412
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44226001
47GATA3_27048872_Chip-Seq_THYMUS_Human1.40532270
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38752806
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.37411074
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.35658633
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30132068
52* GATA3_26560356_Chip-Seq_TH2_Human1.29160618
53CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28578132
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27598139
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.27411760
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26212032
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26037594
58EGR1_19032775_ChIP-ChIP_M12_Human1.25439305
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25328097
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23889237
61* BCL6_27268052_Chip-Seq_Bcells_Human1.20900595
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20708081
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20401567
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19838011
65* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19003394
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17408622
67BCOR_27268052_Chip-Seq_Bcells_Human1.15111514
68* MAF_26560356_Chip-Seq_TH2_Human1.12928246
69E2F7_22180533_ChIP-Seq_HELA_Human1.12890190
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11854939
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.09180275
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08673218
73GATA1_19941826_ChIP-Seq_K562_Human1.06385986
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06169026
75NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05392469
76SCL_19346495_ChIP-Seq_HPC-7_Human1.05378800
77UTX_26944678_Chip-Seq_JUKART_Human1.03023070
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02559369
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97161979
80SA1_27219007_Chip-Seq_ERYTHROID_Human0.96369321
81RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95767528
82RACK7_27058665_Chip-Seq_MCF-7_Human0.95413286
83GATA1_22025678_ChIP-Seq_K562_Human0.95042355
84TCF7_22412390_ChIP-Seq_EML_Mouse0.94418209
85GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93641379
86NCOR1_26117541_ChIP-Seq_K562_Human0.92665234
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91905274
88SMRT_27268052_Chip-Seq_Bcells_Human0.91827382
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91633357
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89136644
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88112545
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.85780987
93GATA2_19941826_ChIP-Seq_K562_Human0.82951665
94* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82870827
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.82085898
96ELK3_25401928_ChIP-Seq_HUVEC_Human0.81418278
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79328115
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.78390583
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.74283488
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.74283488
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.72733838
102KDM2B_26808549_Chip-Seq_SUP-B15_Human0.70655066
103KDM2B_26808549_Chip-Seq_DND41_Human0.70167071
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68742737
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.65845786
106PU.1_20513432_ChIP-Seq_Bcells_Mouse0.61206550
107IKZF1_21737484_ChIP-ChIP_HCT116_Human0.60344820
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.60003809
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.59988651
110KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.59590758
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.58734727
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58643249
113KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.58219826
114KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.58219826
115KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.58219826
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.57814028
117SPI1_20517297_ChIP-Seq_HL60_Human0.56278290
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.54959756
119ELF1_17652178_ChIP-ChIP_JURKAT_Human0.54407919
120GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.54333371
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.52745408
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.51279803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.68672990
2MP0003436_decreased_susceptibility_to4.10744799
3MP0009785_altered_susceptibility_to4.07945178
4MP0002148_abnormal_hypersensitivity_rea3.62750380
5MP0000685_abnormal_immune_system3.51583450
6MP0002138_abnormal_hepatobiliary_system3.48991761
7MP0001348_abnormal_lacrimal_gland3.19843100
8MP0003303_peritoneal_inflammation3.16968481
9MP0005671_abnormal_response_to3.15971344
10MP0002163_abnormal_gland_morphology3.13558916
11MP0004510_myositis3.04543197
12MP0005000_abnormal_immune_tolerance3.01734561
13MP0001790_abnormal_immune_system2.93368512
14MP0005387_immune_system_phenotype2.93368512
15MP0002419_abnormal_innate_immunity2.88524867
16MP0005025_abnormal_response_to2.81794166
17MP0001800_abnormal_humoral_immune2.57514666
18MP0002452_abnormal_antigen_presenting2.54123245
19MP0002723_abnormal_immune_serum2.46136868
20MP0009278_abnormal_bone_marrow2.34579511
21MP0001819_abnormal_immune_cell2.34192747
22MP0001853_heart_inflammation2.30016397
23MP0002420_abnormal_adaptive_immunity2.28849024
24MP0002132_abnormal_respiratory_system2.25917393
25MP0005310_abnormal_salivary_gland2.25133718
26MP0001346_abnormal_lacrimal_gland2.06780429
27MP0003724_increased_susceptibility_to2.03014749
28MP0002277_abnormal_respiratory_mucosa2.02534437
29MP0002254_reproductive_system_inflammat2.01414110
30MP0002006_tumorigenesis2.00879002
31MP0002166_altered_tumor_susceptibility1.96832758
32MP0002405_respiratory_system_inflammati1.92194751
33MP0009764_decreased_sensitivity_to1.82363042
34MP0001533_abnormal_skeleton_physiology1.82343312
35MP0000716_abnormal_immune_system1.77604998
36MP0001545_abnormal_hematopoietic_system1.76055737
37MP0005397_hematopoietic_system_phenotyp1.76055737
38MP0006082_CNS_inflammation1.72487355
39MP0000465_gastrointestinal_hemorrhage1.72235986
40MP0002398_abnormal_bone_marrow1.71945202
41MP0003866_abnormal_defecation1.70944804
42MP0001845_abnormal_inflammatory_respons1.70200240
43MP0003448_altered_tumor_morphology1.70135564
44MP0000858_altered_metastatic_potential1.61477084
45MP0000569_abnormal_digit_pigmentation1.60332454
46MP0005451_abnormal_body_composition1.56563946
47MP0004381_abnormal_hair_follicle1.54130757
48MP0010155_abnormal_intestine_physiology1.52855638
49MP0005379_endocrine/exocrine_gland_phen1.47070082
50MP0004947_skin_inflammation1.46858736
51MP0005464_abnormal_platelet_physiology1.39856098
52MP0002429_abnormal_blood_cell1.38077460
53MP0005167_abnormal_blood-brain_barrier1.37784197
54MP0008469_abnormal_protein_level1.32578556
55MP0005076_abnormal_cell_differentiation1.23785834
56MP0000343_altered_response_to1.23613121
57MP0008260_abnormal_autophagy1.21155628
58MP0003183_abnormal_peptide_metabolism1.21086731
59MP0002722_abnormal_immune_system1.20003693
60MP0004808_abnormal_hematopoietic_stem1.19471362
61MP0000689_abnormal_spleen_morphology1.17847270
62MP0009333_abnormal_splenocyte_physiolog1.14894499
63MP0003075_altered_response_to1.10914241
64MP0002009_preneoplasia1.09165838
65MP0002735_abnormal_chemical_nociception1.06444729
66MP0003763_abnormal_thymus_physiology1.05016057
67MP0005174_abnormal_tail_pigmentation1.04643352
68MP0003878_abnormal_ear_physiology1.03702375
69MP0005377_hearing/vestibular/ear_phenot1.03702375
70MP0001873_stomach_inflammation1.02907359
71MP0002396_abnormal_hematopoietic_system1.00739672
72MP0002933_joint_inflammation1.00569243
73MP0008057_abnormal_DNA_replication1.00261921
74MP0003453_abnormal_keratinocyte_physiol0.97296574
75MP0003690_abnormal_glial_cell0.97293819
76MP0010352_gastrointestinal_tract_polyps0.91911980
77MP0004883_abnormal_blood_vessel0.90699666
78MP0003806_abnormal_nucleotide_metabolis0.88207866
79MP0004858_abnormal_nervous_system0.87148143
80MP0003045_fibrosis0.85129955
81MP0003300_gastrointestinal_ulcer0.85018291
82MP0003091_abnormal_cell_migration0.84879893
83MP0008004_abnormal_stomach_pH0.83064158
84MP0001663_abnormal_digestive_system0.82902082
85MP0000703_abnormal_thymus_morphology0.79488589
86MP0000015_abnormal_ear_pigmentation0.78561586
87MP0005390_skeleton_phenotype0.78391706
88MP0005075_abnormal_melanosome_morpholog0.76669355
89MP0002998_abnormal_bone_remodeling0.76273811
90MP0001986_abnormal_taste_sensitivity0.76148702
91MP0002877_abnormal_melanocyte_morpholog0.74067863
92MP0010307_abnormal_tumor_latency0.73296923
93MP0005058_abnormal_lysosome_morphology0.72002054
94MP0003828_pulmonary_edema0.69424173
95MP0003566_abnormal_cell_adhesion0.69213933
96MP0005164_abnormal_response_to0.68550284
97MP0009763_increased_sensitivity_to0.66505066
98MP0003172_abnormal_lysosome_physiology0.66387468
99MP0001881_abnormal_mammary_gland0.66342726
100MP0002837_dystrophic_cardiac_calcinosis0.66279693
101MP0005248_abnormal_Harderian_gland0.65611939
102MP0003795_abnormal_bone_structure0.64302778
103MP0000249_abnormal_blood_vessel0.63393799
104MP0008874_decreased_physiological_sensi0.62167805
105MP0005319_abnormal_enzyme/_coenzyme0.61499409
106MP0003186_abnormal_redox_activity0.61067917
107MP0001851_eye_inflammation0.60582639
108MP0003221_abnormal_cardiomyocyte_apopto0.59862899
109MP0005166_decreased_susceptibility_to0.59539987
110MP0009765_abnormal_xenobiotic_induced0.59425290
111MP0005083_abnormal_biliary_tract0.59086459
112MP0002019_abnormal_tumor_incidence0.57585331
113MP0002736_abnormal_nociception_after0.56573070
114MP0004130_abnormal_muscle_cell0.56049076
115MP0002133_abnormal_respiratory_system0.54464543
116MP0005388_respiratory_system_phenotype0.54464543
117MP0000627_abnormal_mammary_gland0.53756867
118MP0000604_amyloidosis0.52705383
119MP0001968_abnormal_touch/_nociception0.51967659
120MP0002653_abnormal_ependyma_morphology0.51446906
121MP0000490_abnormal_crypts_of0.50916072
122MP0000371_diluted_coat_color0.50420593
123MP0003191_abnormal_cellular_cholesterol0.50315482
124MP0002928_abnormal_bile_duct0.49643184
125MP0000516_abnormal_urinary_system0.47728024
126MP0001958_emphysema0.46967711
127MP0002693_abnormal_pancreas_physiology0.46939742
128MP0002332_abnormal_exercise_endurance0.44566621

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.79767729
2Recurrent abscess formation (HP:0002722)7.36205570
3Recurrent bacterial skin infections (HP:0005406)6.82444133
4Recurrent gram-negative bacterial infections (HP:0005420)6.27291128
5Optic neuritis (HP:0100653)5.46459142
6Retrobulbar optic neuritis (HP:0100654)5.46459142
7Abnormality of macrophages (HP:0004311)5.45048383
8Orchitis (HP:0100796)5.24470787
9Mediastinal lymphadenopathy (HP:0100721)5.24055084
10Myositis (HP:0100614)5.12920599
11Increased IgM level (HP:0003496)5.05372840
12Hypochromic microcytic anemia (HP:0004840)5.03640180
13Recurrent fungal infections (HP:0002841)4.91481390
14Chronic obstructive pulmonary disease (HP:0006510)4.62786027
15Obstructive lung disease (HP:0006536)4.62786027
16Gastrointestinal infarctions (HP:0005244)4.53252138
17Gingivitis (HP:0000230)4.44663953
18Autoimmune thrombocytopenia (HP:0001973)4.33847587
19Recurrent skin infections (HP:0001581)4.21268215
20Elevated erythrocyte sedimentation rate (HP:0003565)4.11772872
21Vasculitis (HP:0002633)4.05527106
22Stomatitis (HP:0010280)3.95440186
23Chronic otitis media (HP:0000389)3.83620923
24Episodic fever (HP:0001954)3.46412989
25Recurrent viral infections (HP:0004429)3.46030614
26Keratoconjunctivitis sicca (HP:0001097)3.45399498
27Cellulitis (HP:0100658)3.43463399
28Prolonged bleeding time (HP:0003010)3.39207364
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.37350447
30Meningitis (HP:0001287)3.36720239
31Urticaria (HP:0001025)3.35328608
32Leukocytosis (HP:0001974)3.25558435
33Keratoconjunctivitis (HP:0001096)3.18603782
34Recurrent cutaneous fungal infections (HP:0011370)3.14627464
35Chronic mucocutaneous candidiasis (HP:0002728)3.14627464
36Arterial thrombosis (HP:0004420)3.12340957
37Eosinophilia (HP:0001880)3.05294368
38Pulmonary infiltrates (HP:0002113)3.04678734
39Hypergammaglobulinemia (HP:0010702)3.00370197
40Hemoptysis (HP:0002105)2.92630510
41Abnormality of T cell number (HP:0011839)2.87496038
42Microcytic anemia (HP:0001935)2.86688458
43Recurrent pneumonia (HP:0006532)2.80631820
44Periodontitis (HP:0000704)2.74345185
45Gastrointestinal inflammation (HP:0004386)2.70905078
46Granulocytopenia (HP:0001913)2.65925839
47Hypochromic anemia (HP:0001931)2.64629332
48Increased IgE level (HP:0003212)2.63502015
49Tetraparesis (HP:0002273)2.62459689
50Epistaxis (HP:0000421)2.60725573
51Nasal polyposis (HP:0100582)2.59426366
52Basal ganglia calcification (HP:0002135)2.58191634
53Thyroiditis (HP:0100646)2.57835245
54Panhypogammaglobulinemia (HP:0003139)2.56724675
55Peritonitis (HP:0002586)2.56350369
56Abnormality of eosinophils (HP:0001879)2.53965685
57Osteomyelitis (HP:0002754)2.51012775
58Encephalitis (HP:0002383)2.48766516
59Gingival bleeding (HP:0000225)2.48412332
60Spontaneous hematomas (HP:0007420)2.46525893
61Abnormality of the peritoneum (HP:0002585)2.43897569
62Porencephaly (HP:0002132)2.42851745
63Abnormality of cells of the lymphoid lineage (HP:0012140)2.38498229
64Recurrent lower respiratory tract infections (HP:0002783)2.37077573
65Chest pain (HP:0100749)2.32603825
66Premature loss of primary teeth (HP:0006323)2.31491720
67Interstitial pulmonary disease (HP:0006530)2.31207844
68Hematochezia (HP:0002573)2.30455805
69Abnormality of the heme biosynthetic pathway (HP:0010472)2.24295538
70Sepsis (HP:0100806)2.24253983
71Metaphyseal cupping (HP:0003021)2.24154983
72Abnormality of the nasal mucosa (HP:0000433)2.22908217
73Toxemia of pregnancy (HP:0100603)2.22394988
74Anorexia (HP:0002039)2.21514392
75Pustule (HP:0200039)2.18354630
76Autoimmune hemolytic anemia (HP:0001890)2.18285753
77Glomerulopathy (HP:0100820)2.15895436
78Chronic sinusitis (HP:0011109)2.13473340
79Skin ulcer (HP:0200042)2.13098916
80Gangrene (HP:0100758)2.12977446
81Joint swelling (HP:0001386)2.12856388
82Systemic lupus erythematosus (HP:0002725)2.12639131
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12584528
84Acne (HP:0001061)2.11952988
85Lymphopenia (HP:0001888)2.11882771
86Amaurosis fugax (HP:0100576)2.09504817
87Fatigue (HP:0012378)2.08973887
88Abnormality of T cells (HP:0002843)2.08641903
89Keratitis (HP:0000491)2.07984781
90Abnormal platelet volume (HP:0011876)2.07712527
91Difficulty running (HP:0009046)2.06961969
92Agammaglobulinemia (HP:0004432)2.06876176
93T lymphocytopenia (HP:0005403)2.06031317
94IgM deficiency (HP:0002850)2.03017439
95Recurrent bronchitis (HP:0002837)2.02881347
96Pulmonary embolism (HP:0002204)2.02048526
97Myocardial infarction (HP:0001658)2.01997940
98Purpura (HP:0000979)2.01968472
99Acute hepatic failure (HP:0006554)2.00750415
100Slow saccadic eye movements (HP:0000514)1.99387115
101Colitis (HP:0002583)1.98923251
102Abnormality of T cell physiology (HP:0011840)1.98318996
103Segmental peripheral demyelination/remyelination (HP:0003481)1.96299679
104Vertigo (HP:0002321)1.94520301
105Polycythemia (HP:0001901)1.91250772
106Hypermelanotic macule (HP:0001034)1.90953502
107Vacuolated lymphocytes (HP:0001922)1.88654534
108Abnormality of the fingertips (HP:0001211)1.88041618
109Abnormality of the pleura (HP:0002103)1.87035269
110Hepatosplenomegaly (HP:0001433)1.86365266
111Petechiae (HP:0000967)1.86271483
112Abnormality of iron homeostasis (HP:0011031)1.86202151
113Loss of speech (HP:0002371)1.85654290
114Abnormality of the endocardium (HP:0004306)1.85397099
115Increased serum ferritin (HP:0003281)1.84665074
116Subacute progressive viral hepatitis (HP:0006572)1.84469684
117Arthralgia (HP:0002829)1.84362646
118Viral hepatitis (HP:0006562)1.81650970
119Thrombocytosis (HP:0001894)1.81491103
120Cleft eyelid (HP:0000625)1.80191400
121Abnormal hemoglobin (HP:0011902)1.79887538
122Neutropenia (HP:0001875)1.79826777
123Vertebral compression fractures (HP:0002953)1.78853813
124Skin rash (HP:0000988)1.78790714
125Anhidrosis (HP:0000970)1.77813025
126Cerebral ischemia (HP:0002637)1.76828466
127Prostate neoplasm (HP:0100787)1.76131530
128Abnormality of proline metabolism (HP:0010907)1.75425815
129Hydroxyprolinuria (HP:0003080)1.75425815
130Inflammation of the large intestine (HP:0002037)1.74596863
131Abnormality of the pericardium (HP:0001697)1.73685955
132Amyloidosis (HP:0011034)1.73500631
133Osteolytic defects of the hand bones (HP:0009699)1.73178577
134Osteolytic defects of the phalanges of the hand (HP:0009771)1.73178577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.62449828
2IRAK44.55038468
3RIPK43.40046013
4TYK23.39358326
5BLK3.25909595
6IKBKB3.21737397
7TBK13.07787536
8TNK22.84551870
9JAK32.82489301
10EPHB12.77737452
11MAP3K132.70423083
12IKBKE2.58164840
13IRAK32.42033263
14CHUK2.30092476
15TAOK12.20124212
16MAP3K31.98868458
17JAK11.96498383
18PRPF4B1.79136309
19SIK31.68727521
20PBK1.66119466
21EPHA31.65110790
22BTK1.57922763
23MAP4K11.55782685
24FGR1.55514559
25CSK1.55077746
26TXK1.49679207
27PIM21.43500452
28BCR1.34144094
29TEC1.33517255
30PIM11.32171960
31STK41.27392758
32HCK1.26562103
33EIF2AK21.24400463
34SYK1.22888794
35PRKD21.21950362
36TRPM71.19126857
37FGFR31.16109734
38MARK21.15360328
39NEK91.13454634
40MST41.12598778
41MARK31.12214371
42SMG11.09920197
43TRIB31.07697318
44FES1.07082913
45IRAK11.06225149
46JAK21.02260961
47MAP3K121.01253345
48FGFR41.00309328
49KIT0.99125068
50GRK60.99034801
51CDK190.99027639
52MAP3K90.98792082
53BMPR20.98762898
54LCK0.94147162
55ZAP700.90373745
56MAP3K60.89443015
57FRK0.87223257
58TAOK20.87035977
59PDK10.85049857
60YES10.84127394
61CSF1R0.84111722
62PTK60.83391458
63STK100.83039680
64LYN0.79011935
65ALK0.78552717
66MAP3K70.78503916
67MAP2K40.78336195
68RPS6KA40.77429113
69CLK10.77302082
70PDPK10.77166741
71NLK0.76638966
72MAP2K30.76111907
73PRKCD0.73664085
74PKN10.72430610
75FYN0.72284961
76STK380.71675631
77MAPKAPK20.71394675
78BMX0.65559237
79SIK20.65228079
80DYRK1B0.65207295
81ITK0.64895879
82SIK10.64476512
83PRKG20.64178320
84KSR20.63744284
85ERBB30.63010452
86MAP3K20.62676274
87TESK10.62219079
88CDK120.61433322
89TESK20.59370832
90ARAF0.58697512
91NUAK10.57813525
92MAP2K60.57529582
93MAPK120.57213088
94MAP3K50.54990385
95CDC42BPA0.54344651
96MAP3K110.52995412
97RPS6KA10.52853016
98PRKAA20.52747149
99KDR0.52413854
100TGFBR20.51951624
101RAF10.51766906
102DAPK20.51121308
103HIPK20.50419247
104LRRK20.49858096
105IRAK20.49776524
106RET0.49694033
107MATK0.48205326
108SGK30.45900431
109KSR10.45821468
110RPS6KL10.44783679
111RPS6KC10.44783679
112MAPK70.44287569
113ABL10.42792380
114PRKCQ0.42733463
115PAK40.42315362
116ABL20.36364294
117STK240.35003463
118PTK2B0.34565570
119PIK3CG0.34250476
120EGFR0.34201265
121PRKCH0.34171152
122MAP3K10.34029730
123ERN10.33976253
124RPS6KA50.31692198
125AKT10.30947875
126BMPR1B0.29669662
127RPS6KA60.29283360
128PRKCZ0.28876462
129CAMKK10.27329266
130PTK20.26231412
131MAP2K20.25456417
132MAP3K80.24148743
133RPS6KA20.21845599
134MOS0.21327097
135TAOK30.21265859
136STK110.20744039

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.05562181
2Graft-versus-host disease_Homo sapiens_hsa053323.53273753
3Leishmaniasis_Homo sapiens_hsa051403.28553327
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.76558770
5Asthma_Homo sapiens_hsa053102.71087267
6Autoimmune thyroid disease_Homo sapiens_hsa053202.60466033
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.60053897
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.45113635
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.40543075
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.26765156
11Type I diabetes mellitus_Homo sapiens_hsa049402.24417293
12Measles_Homo sapiens_hsa051622.19797887
13Osteoclast differentiation_Homo sapiens_hsa043802.10817604
14TNF signaling pathway_Homo sapiens_hsa046682.10637713
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.10304278
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91627751
17Legionellosis_Homo sapiens_hsa051341.88465779
18Chemokine signaling pathway_Homo sapiens_hsa040621.86765115
19Pertussis_Homo sapiens_hsa051331.78765116
20Influenza A_Homo sapiens_hsa051641.77948329
21Staphylococcus aureus infection_Homo sapiens_hsa051501.73948325
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.70061348
23Toxoplasmosis_Homo sapiens_hsa051451.68421101
24Herpes simplex infection_Homo sapiens_hsa051681.67821665
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.66336976
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.59906207
27Viral myocarditis_Homo sapiens_hsa054161.57744148
28Tuberculosis_Homo sapiens_hsa051521.55735583
29African trypanosomiasis_Homo sapiens_hsa051431.55338547
30Shigellosis_Homo sapiens_hsa051311.54492414
31Apoptosis_Homo sapiens_hsa042101.49899019
32Rheumatoid arthritis_Homo sapiens_hsa053231.47548505
33Malaria_Homo sapiens_hsa051441.38005708
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37319272
35B cell receptor signaling pathway_Homo sapiens_hsa046621.31302531
36Hematopoietic cell lineage_Homo sapiens_hsa046401.30920038
37Salmonella infection_Homo sapiens_hsa051321.29721275
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28723138
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26819438
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.22267655
41Primary immunodeficiency_Homo sapiens_hsa053401.20496103
42Hepatitis B_Homo sapiens_hsa051611.14142788
43Prolactin signaling pathway_Homo sapiens_hsa049171.08793664
44Acute myeloid leukemia_Homo sapiens_hsa052211.06999438
45Antigen processing and presentation_Homo sapiens_hsa046121.00988616
46Epstein-Barr virus infection_Homo sapiens_hsa051691.00658266
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96565419
48Hepatitis C_Homo sapiens_hsa051600.96020879
49T cell receptor signaling pathway_Homo sapiens_hsa046600.94722481
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86723564
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86230690
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85049695
53Phagosome_Homo sapiens_hsa041450.84225835
54Renal cell carcinoma_Homo sapiens_hsa052110.83370511
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82750633
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.78694166
57Other glycan degradation_Homo sapiens_hsa005110.78484623
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76363988
59p53 signaling pathway_Homo sapiens_hsa041150.74683072
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73785276
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73495663
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73420626
63Choline metabolism in cancer_Homo sapiens_hsa052310.66913206
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65692211
65Regulation of autophagy_Homo sapiens_hsa041400.65545772
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.65396055
67Amoebiasis_Homo sapiens_hsa051460.62767914
68Chronic myeloid leukemia_Homo sapiens_hsa052200.61654463
69Viral carcinogenesis_Homo sapiens_hsa052030.59827187
70GnRH signaling pathway_Homo sapiens_hsa049120.58974461
71Pancreatic cancer_Homo sapiens_hsa052120.57246796
72Small cell lung cancer_Homo sapiens_hsa052220.56022757
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.55842499
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55829881
75Proteasome_Homo sapiens_hsa030500.55111777
76Platelet activation_Homo sapiens_hsa046110.50132791
77mTOR signaling pathway_Homo sapiens_hsa041500.47964614
78VEGF signaling pathway_Homo sapiens_hsa043700.47605736
79Type II diabetes mellitus_Homo sapiens_hsa049300.45697653
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43400809
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.42746440
82MicroRNAs in cancer_Homo sapiens_hsa052060.42459113
83HTLV-I infection_Homo sapiens_hsa051660.41875286
84ErbB signaling pathway_Homo sapiens_hsa040120.41330554
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40297023
86Insulin signaling pathway_Homo sapiens_hsa049100.39275434
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38959178
88MAPK signaling pathway_Homo sapiens_hsa040100.38595646
89FoxO signaling pathway_Homo sapiens_hsa040680.37539659
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.36732869
91Estrogen signaling pathway_Homo sapiens_hsa049150.36443864
92HIF-1 signaling pathway_Homo sapiens_hsa040660.34638965
93Dorso-ventral axis formation_Homo sapiens_hsa043200.33874590
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32710590
95Lysosome_Homo sapiens_hsa041420.31922397
96Pathways in cancer_Homo sapiens_hsa052000.30567618
97Adherens junction_Homo sapiens_hsa045200.28913823
98Insulin resistance_Homo sapiens_hsa049310.28249247
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27172184
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25867124
101Non-small cell lung cancer_Homo sapiens_hsa052230.25272881
102Phenylalanine metabolism_Homo sapiens_hsa003600.22974602
103Endometrial cancer_Homo sapiens_hsa052130.21454220
104Proteoglycans in cancer_Homo sapiens_hsa052050.21173048
105Prostate cancer_Homo sapiens_hsa052150.19259451
106Notch signaling pathway_Homo sapiens_hsa043300.19200184
107Endocytosis_Homo sapiens_hsa041440.18596046
108Inositol phosphate metabolism_Homo sapiens_hsa005620.16230177
109Rap1 signaling pathway_Homo sapiens_hsa040150.14741960
110Colorectal cancer_Homo sapiens_hsa052100.14457170
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.13768786
112Bladder cancer_Homo sapiens_hsa052190.13626813
113Melanoma_Homo sapiens_hsa052180.13476271
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13404268

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