ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	interleukin-6-mediated signaling pathway (GO:0070102)	8.85977272
2	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	8.78393104
3	histone-serine phosphorylation (GO:0035404)	7.19022911
4	lung lobe morphogenesis (GO:0060463)	6.81577249
5	prostate gland growth (GO:0060736)	6.60612917
6	lung vasculature development (GO:0060426)	6.07669264
7	response to pheromone (GO:0019236)	6.04416267
8	exocrine pancreas development (GO:0031017)	5.88440181
9	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	5.70258250
10	positive regulation of muscle hypertrophy (GO:0014742)	5.64799452
11	positive regulation of cardiac muscle hypertrophy (GO:0010613)	5.64799452
12	kynurenine metabolic process (GO:0070189)	5.51183717
13	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	5.33246260
14	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	5.33246260
15	epithelial cell maturation (GO:0002070)	5.23838174
16	sulfate transmembrane transport (GO:1902358)	5.17250056
17	tryptophan catabolic process (GO:0006569)	5.16739896
18	indole-containing compound catabolic process (GO:0042436)	5.16739896
19	indolalkylamine catabolic process (GO:0046218)	5.16739896
20	branching involved in prostate gland morphogenesis (GO:0060442)	5.13381739
21	production of molecular mediator involved in inflammatory response (GO:0002532)	5.07125089
22	regulation of cell maturation (GO:1903429)	5.02939752
23	insulin-like growth factor receptor signaling pathway (GO:0048009)	5.02791549
24	histone H3-K4 trimethylation (GO:0080182)	5.01959063
25	positive regulation of glycolytic process (GO:0045821)	4.61963506
26	dopamine transport (GO:0015872)	4.56211624
27	lung secretory cell differentiation (GO:0061140)	4.51501683
28	regulation of acrosome reaction (GO:0060046)	4.50774077
29	regulation of cardiac muscle hypertrophy (GO:0010611)	4.49325923
30	negative regulation of neurotransmitter transport (GO:0051589)	4.41270035
31	regulation of muscle hypertrophy (GO:0014743)	4.31844910
32	sulfate transport (GO:0008272)	4.31744350
33	positive regulation of protein import into nucleus, translocation (GO:0033160)	4.24873826
34	interleukin-1-mediated signaling pathway (GO:0070498)	4.24321839
35	translesion synthesis (GO:0019985)	4.23570835
36	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	4.09992134
37	nucleoside bisphosphate biosynthetic process (GO:0033866)	4.09992134
38	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	4.09992134
39	tryptophan metabolic process (GO:0006568)	4.04195139
40	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	3.97324027
41	neuron fate determination (GO:0048664)	3.95224929
42	positive regulation of smooth muscle cell migration (GO:0014911)	3.90140584
43	cellular response to interleukin-6 (GO:0071354)	3.89474294
44	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	3.89051013
45	centrosome localization (GO:0051642)	3.86465737
46	protein localization to microtubule cytoskeleton (GO:0072698)	3.86087490
47	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.82504898
48	positive regulation of histone H3-K4 methylation (GO:0051571)	3.77652786
49	cell morphogenesis involved in neuron differentiation (GO:0048667)	3.71040924
50	ovulation from ovarian follicle (GO:0001542)	3.70641904
51	negative regulation of androgen receptor signaling pathway (GO:0060766)	3.67376075
52	glycoprotein catabolic process (GO:0006516)	3.67255037
53	protein localization to cytoskeleton (GO:0044380)	3.59557583
54	kidney morphogenesis (GO:0060993)	3.53999799
55	positive regulation of DNA-templated transcription, initiation (GO:2000144)	3.51748064
56	connective tissue development (GO:0061448)	3.48945815
57	positive regulation of glycogen biosynthetic process (GO:0045725)	3.29880092
58	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.29530986
59	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.28034010
60	intestinal epithelial cell development (GO:0060576)	3.27704005
61	urinary tract smooth muscle contraction (GO:0014848)	3.25151293
62	spinal cord motor neuron differentiation (GO:0021522)	3.21146070
63	columnar/cuboidal epithelial cell development (GO:0002066)	3.17219632
64	innate immune response in mucosa (GO:0002227)	3.15397574
65	basic amino acid transport (GO:0015802)	3.14828771
66	positive regulation of glial cell differentiation (GO:0045687)	3.14436992
67	cell fate commitment involved in formation of primary germ layer (GO:0060795)	3.09592323
68	aromatic amino acid family catabolic process (GO:0009074)	3.08264569
69	indolalkylamine metabolic process (GO:0006586)	3.07986928
70	response to interleukin-6 (GO:0070741)	3.07257891
71	replicative senescence (GO:0090399)	3.05148567
72	regulation of pigment cell differentiation (GO:0050932)	3.02261300
73	neurotransmitter catabolic process (GO:0042135)	3.00932384
74	myoblast differentiation (GO:0045445)	3.00780642
75	regulation of muscle adaptation (GO:0043502)	3.00503987
76	Leydig cell differentiation (GO:0033327)	2.99704624
77	acrosome reaction (GO:0007340)	2.99368863
78	phenol-containing compound catabolic process (GO:0019336)	2.99168571
79	cellular biogenic amine catabolic process (GO:0042402)	2.99063420
80	amine catabolic process (GO:0009310)	2.99063420
81	regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)	2.96938072
82	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	2.94326481
83	cellular zinc ion homeostasis (GO:0006882)	2.94037934
84	positive regulation of developmental pigmentation (GO:0048087)	2.93947005
85	oogenesis (GO:0048477)	2.86825143
86	growth hormone receptor signaling pathway (GO:0060396)	2.86757004
87	fibroblast migration (GO:0010761)	2.85767114
88	regulation of smooth muscle cell apoptotic process (GO:0034391)	2.83457679
89	diacylglycerol metabolic process (GO:0046339)	2.83040528
90	cell differentiation in spinal cord (GO:0021515)	2.79835467
91	histone H2B ubiquitination (GO:0033523)	2.78602366
92	C4-dicarboxylate transport (GO:0015740)	2.77427000
93	regulation of glycolytic process (GO:0006110)	2.75141177
94	negative regulation of complement activation (GO:0045916)	2.73785763
95	zinc ion transmembrane transport (GO:0071577)	2.71793389
96	positive regulation of glycogen metabolic process (GO:0070875)	2.69878177
97	male genitalia development (GO:0030539)	2.67761933
98	interkinetic nuclear migration (GO:0022027)	2.67719517
99	type B pancreatic cell development (GO:0003323)	2.66993141
100	parturition (GO:0007567)	16.1059181

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.87468289
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.81178932
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.64786204
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.39872938
5	VDR_22108803_ChIP-Seq_LS180_Human	2.29397860
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	15.7493480
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.78987650
8	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.78049454
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.71533415
10	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.67420353
11	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.62751967
12	* POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.60716089
13	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.59363402
14	AR_21572438_ChIP-Seq_LNCaP_Human	1.58972999
15	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.55079227
16	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.52900156
17	HTT_18923047_ChIP-ChIP_STHdh_Human	1.49206732
18	GBX2_23144817_ChIP-Seq_PC3_Human	1.47669942
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.47298715
20	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.46234607
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.44568665
22	P300_19829295_ChIP-Seq_ESCs_Human	1.41118198
23	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.40922699
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.40785254
25	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.39244559
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.33688190
27	EZH2_22144423_ChIP-Seq_EOC_Human	1.33002442
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32926055
29	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.32305397
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.32187784
31	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31770046
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.30287542
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.30254969
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29240821
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.29240821
36	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27050196
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.26308782
38	ZNF274_21170338_ChIP-Seq_K562_Hela	1.24373727
39	TAF15_26573619_Chip-Seq_HEK293_Human	1.22742171
40	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22740289
41	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.22422803
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21226671
43	AHR_22903824_ChIP-Seq_MCF-7_Human	1.21218931
44	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.20769004
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.20748536
46	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.20400074
47	STAT3_23295773_ChIP-Seq_U87_Human	1.19677464
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19237295
49	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.15087755
50	TCF4_23295773_ChIP-Seq_U87_Human	1.14469913
51	EWS_26573619_Chip-Seq_HEK293_Human	1.14209944
52	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11122492
53	CDX2_22108803_ChIP-Seq_LS180_Human	1.09981333
54	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08609079
55	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.07629844
56	AR_25329375_ChIP-Seq_VCAP_Human	1.07288336
57	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06388088
58	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.04148230
59	RXR_22108803_ChIP-Seq_LS180_Human	1.03354066
60	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.03038935
61	FUS_26573619_Chip-Seq_HEK293_Human	0.99741300
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99422676
63	TCF4_22108803_ChIP-Seq_LS180_Human	0.98243743
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95998371
65	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.94063227
66	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.91833589
67	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.91493496
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.90320451
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.90176715
70	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.90116869
71	TP53_22573176_ChIP-Seq_HFKS_Human	0.89681963
72	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.89388024
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.89343216
74	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.88995431
75	RNF2_27304074_Chip-Seq_NSC_Mouse	0.86440735
76	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.85782901
77	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.85782901
78	ER_23166858_ChIP-Seq_MCF-7_Human	0.85712400
79	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.85106027
80	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.83294603
81	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.83181352
82	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.83005253
83	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.82656739
84	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.82626788
85	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.81477020
86	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.81344268
87	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.80958641
88	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.80282667
89	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.79147012
90	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.79038713
91	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.78042914
92	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.77617019
93	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.77585489
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.77075368
95	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.76925318
96	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.76788095
97	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.75343581
98	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.74867901
99	GATA1_22025678_ChIP-Seq_K562_Human	0.74751901
100	KDM2B_26808549_Chip-Seq_REH_Human	0.74406486

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010386_abnormal_urinary_bladder	8.38535616
2	MP0002254_reproductive_system_inflammat	6.79848543
3	MP0002160_abnormal_reproductive_system	5.59796629
4	MP0008004_abnormal_stomach_pH	5.25769731
5	MP0003941_abnormal_skin_development	4.55353935
6	MP0005389_reproductive_system_phenotype	3.83979509
7	MP0008057_abnormal_DNA_replication	3.10829000
8	MP0001881_abnormal_mammary_gland	2.81580217
9	MP0000383_abnormal_hair_follicle	2.70809423
10	MP0006054_spinal_hemorrhage	2.55974571
11	MP0010678_abnormal_skin_adnexa	2.32272899
12	MP0003136_yellow_coat_color	2.30619502
13	MP0006072_abnormal_retinal_apoptosis	2.17597025
14	MP0000627_abnormal_mammary_gland	2.09374206
15	MP0003724_increased_susceptibility_to	2.01717940
16	MP0003195_calcinosis	1.91620381
17	MP0003300_gastrointestinal_ulcer	1.78216968
18	MP0004272_abnormal_basement_membrane	1.77919712
19	MP0009780_abnormal_chondrocyte_physiolo	1.75875301
20	MP0001919_abnormal_reproductive_system	1.66610750
21	MP0003638_abnormal_response/metabolism_	1.60208221
22	MP0000465_gastrointestinal_hemorrhage	1.51894479
23	MP0003787_abnormal_imprinting	1.49388405
24	MP0001873_stomach_inflammation	1.37433344
25	MP0001542_abnormal_bone_strength	1.33576997
26	MP0001119_abnormal_female_reproductive	1.32920197
27	MP0003938_abnormal_ear_development	1.31732055
28	MP0008877_abnormal_DNA_methylation	1.27550993
29	MP0005253_abnormal_eye_physiology	1.27543824
30	MP0008438_abnormal_cutaneous_collagen	1.25742587
31	MP0003693_abnormal_embryo_hatching	1.24613638
32	MP0003385_abnormal_body_wall	1.19405622
33	MP0003950_abnormal_plasma_membrane	1.15053566
34	MP0003699_abnormal_female_reproductive	1.02695252
35	MP0000767_abnormal_smooth_muscle	1.01887970
36	MP0006292_abnormal_olfactory_placode	1.00962357
37	MP0003646_muscle_fatigue	0.98607751
38	MP0003632_abnormal_nervous_system	0.98241331
39	MP0005248_abnormal_Harderian_gland	0.97711669
40	MP0000427_abnormal_hair_cycle	0.97643234
41	MP0005360_urolithiasis	0.96515559
42	MP0002108_abnormal_muscle_morphology	0.95024178
43	MP0010234_abnormal_vibrissa_follicle	0.94834318
44	MP0000653_abnormal_sex_gland	0.93783335
45	MP0003718_maternal_effect	0.92011137
46	MP0002210_abnormal_sex_determination	0.88887140
47	MP0003183_abnormal_peptide_metabolism	0.84238009
48	MP0000428_abnormal_craniofacial_morphol	0.83509098
49	MP0003763_abnormal_thymus_physiology	0.80655672
50	MP0001958_emphysema	0.79645359
51	MP0005171_absent_coat_pigmentation	0.78438794
52	MP0003890_abnormal_embryonic-extraembry	0.78083566
53	MP0002736_abnormal_nociception_after	0.74408134
54	MP0001929_abnormal_gametogenesis	0.72702302
55	MP0002932_abnormal_joint_morphology	0.72353778
56	MP0002109_abnormal_limb_morphology	0.72195584
57	MP0001293_anophthalmia	0.71028648
58	MP0001145_abnormal_male_reproductive	0.70051774
59	MP0000733_abnormal_muscle_development	0.69388125
60	MP0003698_abnormal_male_reproductive	0.68754406
61	MP0003936_abnormal_reproductive_system	0.68193504
62	MP0004130_abnormal_muscle_cell	0.67807723
63	MP0000569_abnormal_digit_pigmentation	0.67706125
64	MP0002163_abnormal_gland_morphology	0.65932339
65	MP0000534_abnormal_ureter_morphology	0.65641789
66	MP0001968_abnormal_touch/_nociception	0.64361559
67	MP0003935_abnormal_craniofacial_develop	0.63644641
68	MP0001666_abnormal_nutrient_absorption	0.63229411
69	MP0005395_other_phenotype	0.61837291
70	MP0003252_abnormal_bile_duct	0.59835526
71	MP0005164_abnormal_response_to	0.59281773
72	MP0001175_abnormal_lung_morphology	0.56171869
73	MP0001324_abnormal_eye_pigmentation	0.55683098
74	MP0005646_abnormal_pituitary_gland	0.55538081
75	MP0005410_abnormal_fertilization	0.54770344
76	MP0009703_decreased_birth_body	0.53918627
77	MP0002115_abnormal_skeleton_extremities	0.53095674
78	MP0009250_abnormal_appendicular_skeleto	0.52923069
79	MP0005391_vision/eye_phenotype	0.52914142
80	MP0004264_abnormal_extraembryonic_tissu	0.52005873
81	MP0000538_abnormal_urinary_bladder	0.52003041
82	MP0005275_abnormal_skin_tensile	0.51434502
83	MP0005551_abnormal_eye_electrophysiolog	0.50361906
84	MP0001533_abnormal_skeleton_physiology	0.48679515
85	MP0009115_abnormal_fat_cell	0.47856087
86	MP0003631_nervous_system_phenotype	0.46852093
87	MP0001851_eye_inflammation	0.46277470
88	MP0001835_abnormal_antigen_presentation	0.45992100
89	MP0004883_abnormal_blood_vessel	0.45299902
90	MP0006276_abnormal_autonomic_nervous	0.45210423
91	MP0002168_other_aberrant_phenotype	0.44619083
92	MP0003633_abnormal_nervous_system	0.43598901
93	MP0000163_abnormal_cartilage_morphology	0.43349729
94	MP0000685_abnormal_immune_system	0.43319010
95	MP0002161_abnormal_fertility/fecundity	0.42320886
96	MP0000566_synostosis	0.41512778
97	MP0000470_abnormal_stomach_morphology	0.40728118
98	MP0005503_abnormal_tendon_morphology	0.40660316
99	MP0002933_joint_inflammation	0.40122710
100	MP0005195_abnormal_posterior_eye	0.39423894

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Neonatal short-limb short stature (HP:0008921)	6.58940948
2	Large earlobe (HP:0009748)	6.02315824
3	Flat acetabular roof (HP:0003180)	5.43774171
4	Vertebral clefting (HP:0008428)	5.38848688
5	Flat capital femoral epiphysis (HP:0003370)	5.26688532
6	Breech presentation (HP:0001623)	4.84772469
7	Hip contracture (HP:0003273)	4.27849004
8	Irregular epiphyses (HP:0010582)	4.23430972
9	Spinal cord compression (HP:0002176)	4.01567711
10	Symphalangism affecting the phalanges of the hand (HP:0009773)	3.89455270
11	Congenital stationary night blindness (HP:0007642)	3.72587579
12	Glucose intolerance (HP:0000833)	3.66163078
13	Agammaglobulinemia (HP:0004432)	3.60645853
14	Flattened epiphyses (HP:0003071)	3.57685337
15	Abnormal vertebral ossification (HP:0100569)	3.57492473
16	Vertebral hypoplasia (HP:0008417)	3.54847662
17	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	3.54847662
18	Short middle phalanx of finger (HP:0005819)	3.53892539
19	Abnormal cartilage morphology (HP:0002763)	3.53181885
20	Abnormality of the distal phalanx of the thumb (HP:0009617)	3.48252879
21	Birth length less than 3rd percentile (HP:0003561)	3.42527984
22	Dry hair (HP:0011359)	3.40208471
23	Urethral obstruction (HP:0000796)	3.30918021
24	Cystic hygroma (HP:0000476)	3.20151178
25	Tracheal stenosis (HP:0002777)	3.14174487
26	Scanning speech (HP:0002168)	3.12014494
27	Hydroureter (HP:0000072)	3.09146519
28	Truncal obesity (HP:0001956)	3.06555947
29	Limited hip movement (HP:0008800)	3.03595653
30	Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)	3.01736187
31	Visceral angiomatosis (HP:0100761)	2.97324851
32	Hip dysplasia (HP:0001385)	2.97044267
33	Abnormality of the prostate (HP:0008775)	2.96800925
34	Limited elbow extension (HP:0001377)	2.95763398
35	Mitral stenosis (HP:0001718)	2.87071821
36	Abnormal glucose tolerance (HP:0001952)	2.83987100
37	Volvulus (HP:0002580)	2.80641140
38	Prostate neoplasm (HP:0100787)	2.79291467
39	Proximal placement of thumb (HP:0009623)	2.74380332
40	Amelogenesis imperfecta (HP:0000705)	2.74155024
41	Gastrointestinal stroma tumor (HP:0100723)	2.68435363
42	Hemangiomatosis (HP:0007461)	2.67624805
43	Rhabdomyosarcoma (HP:0002859)	2.62725891
44	Papillary thyroid carcinoma (HP:0002895)	2.61049722
45	Abnormality of the middle phalanges of the hand (HP:0009833)	2.61042446
46	Hypoplasia of the iris (HP:0007676)	2.60228837
47	Recurrent bronchitis (HP:0002837)	2.59086032
48	Hoarse voice (HP:0001609)	2.55130939
49	Neoplasm of head and neck (HP:0012288)	2.54096176
50	Esophageal neoplasm (HP:0100751)	2.54096176
51	Deviation of the thumb (HP:0009603)	2.47230364
52	Vascular calcification (HP:0004934)	2.43943971
53	Proximal tubulopathy (HP:0000114)	2.34536261
54	Cardiovascular calcification (HP:0011915)	2.33921918
55	Tubulointerstitial nephritis (HP:0001970)	2.32115752
56	Bifid tongue (HP:0010297)	2.29108841
57	Anterior segment dysgenesis (HP:0007700)	2.26273366
58	Hypoplastic ilia (HP:0000946)	2.25614705
59	Stillbirth (HP:0003826)	2.22527510
60	Flat face (HP:0012368)	2.21899676
61	Lip pit (HP:0100267)	2.21441867
62	Hyperkalemia (HP:0002153)	2.13413424
63	Vertebral arch anomaly (HP:0008438)	2.12813861
64	Bronchitis (HP:0012387)	2.12351173
65	Neoplasm of the small intestine (HP:0100833)	2.11809828
66	Supernumerary spleens (HP:0009799)	2.10947019
67	Chronic sinusitis (HP:0011109)	2.07980411
68	Persistence of primary teeth (HP:0006335)	2.07178002
69	Neoplasm of the rectum (HP:0100743)	2.07025599
70	Hypoplastic ischia (HP:0003175)	2.05043905
71	Patellar aplasia (HP:0006443)	2.01092165
72	Premature skin wrinkling (HP:0100678)	1.99080142
73	Abnormality of the acetabulum (HP:0003170)	1.97002714
74	Decreased circulating renin level (HP:0003351)	1.96323962
75	Radial bowing (HP:0002986)	1.93363613
76	Abnormality of male internal genitalia (HP:0000022)	1.92803572
77	Abnormality of the epiphyses of the hand (HP:0005924)	1.91537460
78	Neoplasm of striated muscle (HP:0009728)	1.89542038
79	Hyperactive renin-angiotensin system (HP:0000841)	1.88867089
80	Abnormality of transition element cation homeostasis (HP:0011030)	1.87492203
81	Aplasia/Hypoplasia of the patella (HP:0006498)	1.85404420
82	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.83607852
83	Impulsivity (HP:0100710)	1.81424245
84	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.81135671
85	Sandal gap (HP:0001852)	1.80209647
86	Thickened nuchal skin fold (HP:0000474)	1.79476092
87	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.79279364
88	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.77319118
89	Abnormality of the ischium (HP:0003174)	1.77000206
90	Overfolded helix (HP:0000396)	1.76400285
91	Enlarged epiphyses (HP:0010580)	1.73719709
92	Abnormality of the middle phalanges of the toes (HP:0010183)	1.72005584
93	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.69462185
94	Duplication of thumb phalanx (HP:0009942)	1.69060374
95	Chin dimple (HP:0010751)	1.68082234
96	Cutaneous finger syndactyly (HP:0010554)	1.67575185
97	Cerebral aneurysm (HP:0004944)	1.66947671
98	Broad metatarsal (HP:0001783)	1.66816790
99	Woolly hair (HP:0002224)	1.65027346
100	Constricted visual fields (HP:0001133)	1.64623492

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	9.01712924
2	TESK2	6.36990103
3	GRK1	3.58514435
4	MARK1	3.44573803
5	TAF1	3.14133895
6	PDK2	3.07843753
7	PIK3CA	2.75253952
8	NLK	2.66632477
9	CSNK1G1	2.53503697
10	MAP3K13	2.42396049
11	PDGFRA	2.27771476
12	ACVR1B	2.15249145
13	PIK3CG	2.13105286
14	CASK	1.98852798
15	CSNK1G3	1.95528756
16	CSNK1G2	1.62913458
17	NEK6	1.51605678
18	PNCK	1.45156901
19	PDGFRB	1.37280650
20	FRK	1.27619916
21	ARAF	1.22269364
22	SGK2	1.20333355
23	DDR2	1.17780622
24	BMPR1B	1.17575708
25	AKT3	1.13150900
26	JAK1	1.12402055
27	CDC42BPA	1.09892176
28	MAPKAPK3	1.06388992
29	TRPM7	1.01748301
30	CAMK1G	1.01437191
31	MELK	0.99635312
32	PBK	0.96521147
33	NME1	0.90822345
34	EIF2AK3	0.90038675
35	ZAK	0.89832411
36	MARK3	0.89824347
37	SGK494	0.84577793
38	SGK223	0.84577793
39	FGFR2	0.83439481
40	CHEK2	0.78576369
41	KSR2	0.76394171
42	NEK9	0.66828402
43	SGK3	0.64030970
44	MAP3K7	0.62039483
45	BRSK2	0.59484130
46	NTRK3	0.59227841
47	NTRK2	0.56095600
48	RET	0.54523255
49	MOS	0.51399421
50	TAOK3	0.48537004
51	MAP2K1	0.48295908
52	CAMK4	0.46605802
53	BRAF	0.41302322
54	MST1R	0.40166115
55	MAPKAPK5	0.35955666
56	TYRO3	0.35898940
57	TGFBR1	0.35405029
58	CSNK1D	0.32908267
59	DYRK1A	0.32640229
60	CAMK1D	0.32175788
61	INSRR	0.31648715
62	MAP3K2	0.30942217
63	MAPK7	0.29970172
64	ADRBK2	0.29284571
65	RPS6KB1	0.28559057
66	RPS6KA6	0.27615330
67	AURKB	0.24732898
68	CDK9	0.23305149
69	MET	0.23238428
70	MAPK4	0.21382571
71	FGFR3	0.21131542
72	CDK7	0.20568345
73	AURKA	0.20485120
74	MAP3K4	0.20342107
75	PDPK1	0.20338477
76	KSR1	0.19821626
77	MATK	0.19407333
78	MST4	0.18236691
79	CSNK1A1	0.17015558
80	MAPK12	0.16229628
81	CAMKK2	0.15942606
82	SGK1	0.15036585
83	PRKCQ	0.12746964
84	CAMK2A	0.12446246
85	PDK1	0.12250012
86	FER	0.11561479
87	CSNK1E	0.10915186
88	ADRBK1	0.10775618
89	JAK2	0.10252222
90	PAK1	0.09940241
91	PRKACA	0.09807065
92	PRKACG	0.08590453
93	CSNK2A2	0.08491090
94	LATS1	0.08178753
95	GSK3A	0.08172978
96	PRKCA	0.07803393
97	EPHA3	0.07487439
98	RAF1	0.07328286
99	WNK3	0.07323187
100	UHMK1	0.07241467

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	9.85406300
2	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	6.36460566
3	Starch and sucrose metabolism_Homo sapiens_hsa00500	2.92873637
4	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.49730985
5	Histidine metabolism_Homo sapiens_hsa00340	2.12234986
6	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	2.05158657
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.02386274
8	Sulfur metabolism_Homo sapiens_hsa00920	1.93604882
9	Tryptophan metabolism_Homo sapiens_hsa00380	1.81718998
10	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.76346412
11	Phototransduction_Homo sapiens_hsa04744	1.50681839
12	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.49230675
13	Melanoma_Homo sapiens_hsa05218	1.46201669
14	One carbon pool by folate_Homo sapiens_hsa00670	1.30344393
15	African trypanosomiasis_Homo sapiens_hsa05143	1.21683621
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.20200251
17	Circadian rhythm_Homo sapiens_hsa04710	1.15467484
18	Propanoate metabolism_Homo sapiens_hsa00640	1.12878890
19	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.11642083
20	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.10676428
21	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.08267628
22	Mineral absorption_Homo sapiens_hsa04978	1.01967020
23	Prostate cancer_Homo sapiens_hsa05215	1.01479130
24	Cocaine addiction_Homo sapiens_hsa05030	0.95105664
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93950643
26	Glioma_Homo sapiens_hsa05214	0.90983881
27	Basal transcription factors_Homo sapiens_hsa03022	0.90855430
28	Long-term depression_Homo sapiens_hsa04730	0.87296450
29	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.85965448
30	Oocyte meiosis_Homo sapiens_hsa04114	0.81210318
31	Phenylalanine metabolism_Homo sapiens_hsa00360	0.79278322
32	Fanconi anemia pathway_Homo sapiens_hsa03460	0.76537608
33	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.76122023
34	Serotonergic synapse_Homo sapiens_hsa04726	0.76078793
35	Purine metabolism_Homo sapiens_hsa00230	0.75628787
36	ABC transporters_Homo sapiens_hsa02010	0.75401318
37	FoxO signaling pathway_Homo sapiens_hsa04068	0.74854982
38	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.73481268
39	Complement and coagulation cascades_Homo sapiens_hsa04610	0.73142956
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.73078791
41	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.71243744
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70785459
43	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.69799951
44	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67366691
45	Tyrosine metabolism_Homo sapiens_hsa00350	0.65435765
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63283729
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.61631119
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.61374812
49	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.60462997
50	Taste transduction_Homo sapiens_hsa04742	0.58634574
51	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56023559
52	ECM-receptor interaction_Homo sapiens_hsa04512	0.52711433
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.52568885
54	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.52563575
55	Amoebiasis_Homo sapiens_hsa05146	0.52481754
56	mTOR signaling pathway_Homo sapiens_hsa04150	0.47676313
57	p53 signaling pathway_Homo sapiens_hsa04115	0.47101541
58	Retinol metabolism_Homo sapiens_hsa00830	0.46350096
59	Focal adhesion_Homo sapiens_hsa04510	0.44252977
60	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.41838012
61	Linoleic acid metabolism_Homo sapiens_hsa00591	0.41631092
62	Protein digestion and absorption_Homo sapiens_hsa04974	0.40831511
63	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.40254654
64	Proteoglycans in cancer_Homo sapiens_hsa05205	0.39077408
65	Thyroid cancer_Homo sapiens_hsa05216	0.38335199
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37920587
67	Renin-angiotensin system_Homo sapiens_hsa04614	0.36353637
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36018015
69	Fatty acid degradation_Homo sapiens_hsa00071	0.32224062
70	Amphetamine addiction_Homo sapiens_hsa05031	0.31249556
71	Olfactory transduction_Homo sapiens_hsa04740	0.31066748
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.30591537
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29250078
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.27908272
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.27674464
76	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.25799333
77	Caffeine metabolism_Homo sapiens_hsa00232	0.25370845
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.24999499
79	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.24731473
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.24529072
81	Gap junction_Homo sapiens_hsa04540	0.24517555
82	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.24412711
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.23501199
84	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.23335619
85	Butanoate metabolism_Homo sapiens_hsa00650	0.21531577
86	Glutamatergic synapse_Homo sapiens_hsa04724	0.21495059
87	Asthma_Homo sapiens_hsa05310	0.21297960
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.21285306
89	Pathways in cancer_Homo sapiens_hsa05200	0.20723313
90	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.20444023
91	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.20314411
92	Adherens junction_Homo sapiens_hsa04520	0.19878789
93	Prolactin signaling pathway_Homo sapiens_hsa04917	0.18032994
94	Small cell lung cancer_Homo sapiens_hsa05222	0.17976449
95	Nicotine addiction_Homo sapiens_hsa05033	0.17687574
96	Platelet activation_Homo sapiens_hsa04611	0.17637734
97	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.17501071
98	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.17397216
99	Homologous recombination_Homo sapiens_hsa03440	0.16612265
100	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.16347855

MMP26

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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