MMP26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interleukin-6-mediated signaling pathway (GO:0070102)8.85977272
2prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060528.78393104
3histone-serine phosphorylation (GO:0035404)7.19022911
4lung lobe morphogenesis (GO:0060463)6.81577249
5prostate gland growth (GO:0060736)6.60612917
6lung vasculature development (GO:0060426)6.07669264
7response to pheromone (GO:0019236)6.04416267
8exocrine pancreas development (GO:0031017)5.88440181
9regulation of calcineurin-NFAT signaling cascade (GO:0070884)5.70258250
10positive regulation of cardiac muscle hypertrophy (GO:0010613)5.64799452
11positive regulation of muscle hypertrophy (GO:0014742)5.64799452
12kynurenine metabolic process (GO:0070189)5.51183717
133-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.33246260
14purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.33246260
15epithelial cell maturation (GO:0002070)5.23838174
16sulfate transmembrane transport (GO:1902358)5.17250056
17indolalkylamine catabolic process (GO:0046218)5.16739896
18tryptophan catabolic process (GO:0006569)5.16739896
19indole-containing compound catabolic process (GO:0042436)5.16739896
20branching involved in prostate gland morphogenesis (GO:0060442)5.13381739
21production of molecular mediator involved in inflammatory response (GO:0002532)5.07125089
22regulation of cell maturation (GO:1903429)5.02939752
23insulin-like growth factor receptor signaling pathway (GO:0048009)5.02791549
24histone H3-K4 trimethylation (GO:0080182)5.01959063
25positive regulation of glycolytic process (GO:0045821)4.61963506
26dopamine transport (GO:0015872)4.56211624
27lung secretory cell differentiation (GO:0061140)4.51501683
28regulation of acrosome reaction (GO:0060046)4.50774077
29regulation of cardiac muscle hypertrophy (GO:0010611)4.49325923
30negative regulation of neurotransmitter transport (GO:0051589)4.41270035
31regulation of muscle hypertrophy (GO:0014743)4.31844910
32sulfate transport (GO:0008272)4.31744350
33positive regulation of protein import into nucleus, translocation (GO:0033160)4.24873826
34interleukin-1-mediated signaling pathway (GO:0070498)4.24321839
35translesion synthesis (GO:0019985)4.23570835
36purine nucleoside bisphosphate biosynthetic process (GO:0034033)4.09992134
37ribonucleoside bisphosphate biosynthetic process (GO:0034030)4.09992134
38nucleoside bisphosphate biosynthetic process (GO:0033866)4.09992134
39tryptophan metabolic process (GO:0006568)4.04195139
40positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.97324027
41neuron fate determination (GO:0048664)3.95224929
42positive regulation of smooth muscle cell migration (GO:0014911)3.90140584
43cellular response to interleukin-6 (GO:0071354)3.89474294
44positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.89051013
45centrosome localization (GO:0051642)3.86465737
46protein localization to microtubule cytoskeleton (GO:0072698)3.86087490
47regulation of establishment or maintenance of cell polarity (GO:0032878)3.82504898
48positive regulation of histone H3-K4 methylation (GO:0051571)3.77652786
49cell morphogenesis involved in neuron differentiation (GO:0048667)3.71040924
50ovulation from ovarian follicle (GO:0001542)3.70641904
51negative regulation of androgen receptor signaling pathway (GO:0060766)3.67376075
52glycoprotein catabolic process (GO:0006516)3.67255037
53protein localization to cytoskeleton (GO:0044380)3.59557583
54kidney morphogenesis (GO:0060993)3.53999799
55positive regulation of DNA-templated transcription, initiation (GO:2000144)3.51748064
56connective tissue development (GO:0061448)3.48945815
57positive regulation of glycogen biosynthetic process (GO:0045725)3.29880092
58positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.29530986
59positive regulation of oligodendrocyte differentiation (GO:0048714)3.28034010
60intestinal epithelial cell development (GO:0060576)3.27704005
61urinary tract smooth muscle contraction (GO:0014848)3.25151293
62spinal cord motor neuron differentiation (GO:0021522)3.21146070
63columnar/cuboidal epithelial cell development (GO:0002066)3.17219632
64innate immune response in mucosa (GO:0002227)3.15397574
65basic amino acid transport (GO:0015802)3.14828771
66positive regulation of glial cell differentiation (GO:0045687)3.14436992
67cell fate commitment involved in formation of primary germ layer (GO:0060795)3.09592323
68aromatic amino acid family catabolic process (GO:0009074)3.08264569
69indolalkylamine metabolic process (GO:0006586)3.07986928
70response to interleukin-6 (GO:0070741)3.07257891
71replicative senescence (GO:0090399)3.05148567
72regulation of pigment cell differentiation (GO:0050932)3.02261300
73neurotransmitter catabolic process (GO:0042135)3.00932384
74myoblast differentiation (GO:0045445)3.00780642
75regulation of muscle adaptation (GO:0043502)3.00503987
76Leydig cell differentiation (GO:0033327)2.99704624
77acrosome reaction (GO:0007340)2.99368863
78phenol-containing compound catabolic process (GO:0019336)2.99168571
79amine catabolic process (GO:0009310)2.99063420
80cellular biogenic amine catabolic process (GO:0042402)2.99063420
81regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.96938072
82regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.94326481
83cellular zinc ion homeostasis (GO:0006882)2.94037934
84positive regulation of developmental pigmentation (GO:0048087)2.93947005
85oogenesis (GO:0048477)2.86825143
86growth hormone receptor signaling pathway (GO:0060396)2.86757004
87fibroblast migration (GO:0010761)2.85767114
88regulation of smooth muscle cell apoptotic process (GO:0034391)2.83457679
89diacylglycerol metabolic process (GO:0046339)2.83040528
90cell differentiation in spinal cord (GO:0021515)2.79835467
91histone H2B ubiquitination (GO:0033523)2.78602366
92C4-dicarboxylate transport (GO:0015740)2.77427000
93regulation of glycolytic process (GO:0006110)2.75141177
94negative regulation of complement activation (GO:0045916)2.73785763
95zinc ion transmembrane transport (GO:0071577)2.71793389
96positive regulation of glycogen metabolic process (GO:0070875)2.69878177
97male genitalia development (GO:0030539)2.67761933
98interkinetic nuclear migration (GO:0022027)2.67719517
99type B pancreatic cell development (GO:0003323)2.66993141
100parturition (GO:0007567)16.1059181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human2.87468289
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.81178932
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64786204
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.39872938
5VDR_22108803_ChIP-Seq_LS180_Human2.29397860
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.7493480
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78987650
8BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78049454
9ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71533415
10ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67420353
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62751967
12* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60716089
13FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59363402
14AR_21572438_ChIP-Seq_LNCaP_Human1.58972999
15ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55079227
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52900156
17HTT_18923047_ChIP-ChIP_STHdh_Human1.49206732
18GBX2_23144817_ChIP-Seq_PC3_Human1.47669942
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.47298715
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46234607
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44568665
22P300_19829295_ChIP-Seq_ESCs_Human1.41118198
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40922699
24BCAT_22108803_ChIP-Seq_LS180_Human1.40785254
25ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.39244559
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33688190
27EZH2_22144423_ChIP-Seq_EOC_Human1.33002442
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32926055
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32305397
30SMAD4_21799915_ChIP-Seq_A2780_Human1.32187784
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31770046
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30287542
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30254969
34CBP_20019798_ChIP-Seq_JUKART_Human1.29240821
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29240821
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27050196
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26308782
38ZNF274_21170338_ChIP-Seq_K562_Hela1.24373727
39TAF15_26573619_Chip-Seq_HEK293_Human1.22742171
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22740289
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22422803
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.21226671
43AHR_22903824_ChIP-Seq_MCF-7_Human1.21218931
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.20769004
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20748536
46FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20400074
47STAT3_23295773_ChIP-Seq_U87_Human1.19677464
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.19237295
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15087755
50TCF4_23295773_ChIP-Seq_U87_Human1.14469913
51EWS_26573619_Chip-Seq_HEK293_Human1.14209944
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11122492
53CDX2_22108803_ChIP-Seq_LS180_Human1.09981333
54RUNX2_22187159_ChIP-Seq_PCA_Human1.08609079
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.07629844
56AR_25329375_ChIP-Seq_VCAP_Human1.07288336
57FLI1_21867929_ChIP-Seq_TH2_Mouse1.06388088
58TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04148230
59RXR_22108803_ChIP-Seq_LS180_Human1.03354066
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03038935
61FUS_26573619_Chip-Seq_HEK293_Human0.99741300
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99422676
63TCF4_22108803_ChIP-Seq_LS180_Human0.98243743
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95998371
65SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94063227
66NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91833589
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91493496
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90320451
69PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90176715
70ESR1_20079471_ChIP-ChIP_T-47D_Human0.90116869
71TP53_22573176_ChIP-Seq_HFKS_Human0.89681963
72CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89388024
73SMAD4_21741376_ChIP-Seq_EPCs_Human0.89343216
74SMAD3_21741376_ChIP-Seq_HESCs_Human0.88995431
75RNF2_27304074_Chip-Seq_NSC_Mouse0.86440735
76NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85782901
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85782901
78ER_23166858_ChIP-Seq_MCF-7_Human0.85712400
79EED_16625203_ChIP-ChIP_MESCs_Mouse0.85106027
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83294603
81CBX2_27304074_Chip-Seq_ESCs_Mouse0.83181352
82CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83005253
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.82656739
84P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82626788
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81477020
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81344268
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.80958641
88RNF2_27304074_Chip-Seq_ESCs_Mouse0.80282667
89NANOG_18555785_Chip-Seq_ESCs_Mouse0.79147012
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.79038713
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.78042914
92EZH2_27304074_Chip-Seq_ESCs_Mouse0.77617019
93FOXO3_23340844_ChIP-Seq_DLD1_Human0.77585489
94SOX2_21211035_ChIP-Seq_LN229_Gbm0.77075368
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.76925318
96SOX2_18555785_Chip-Seq_ESCs_Mouse0.76788095
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.75343581
98AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74867901
99GATA1_22025678_ChIP-Seq_K562_Human0.74751901
100KDM2B_26808549_Chip-Seq_REH_Human0.74406486

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder8.38535616
2MP0002254_reproductive_system_inflammat6.79848543
3MP0002160_abnormal_reproductive_system5.59796629
4MP0008004_abnormal_stomach_pH5.25769731
5MP0003941_abnormal_skin_development4.55353935
6MP0005389_reproductive_system_phenotype3.83979509
7MP0008057_abnormal_DNA_replication3.10829000
8MP0001881_abnormal_mammary_gland2.81580217
9MP0000383_abnormal_hair_follicle2.70809423
10MP0006054_spinal_hemorrhage2.55974571
11MP0010678_abnormal_skin_adnexa2.32272899
12MP0003136_yellow_coat_color2.30619502
13MP0006072_abnormal_retinal_apoptosis2.17597025
14MP0000627_abnormal_mammary_gland2.09374206
15MP0003724_increased_susceptibility_to2.01717940
16MP0003195_calcinosis1.91620381
17MP0003300_gastrointestinal_ulcer1.78216968
18MP0004272_abnormal_basement_membrane1.77919712
19MP0009780_abnormal_chondrocyte_physiolo1.75875301
20MP0001919_abnormal_reproductive_system1.66610750
21MP0003638_abnormal_response/metabolism_1.60208221
22MP0000465_gastrointestinal_hemorrhage1.51894479
23MP0003787_abnormal_imprinting1.49388405
24MP0001873_stomach_inflammation1.37433344
25MP0001542_abnormal_bone_strength1.33576997
26MP0001119_abnormal_female_reproductive1.32920197
27MP0003938_abnormal_ear_development1.31732055
28MP0008877_abnormal_DNA_methylation1.27550993
29MP0005253_abnormal_eye_physiology1.27543824
30MP0008438_abnormal_cutaneous_collagen1.25742587
31MP0003693_abnormal_embryo_hatching1.24613638
32MP0003385_abnormal_body_wall1.19405622
33MP0003950_abnormal_plasma_membrane1.15053566
34MP0003699_abnormal_female_reproductive1.02695252
35MP0000767_abnormal_smooth_muscle1.01887970
36MP0006292_abnormal_olfactory_placode1.00962357
37MP0003646_muscle_fatigue0.98607751
38MP0003632_abnormal_nervous_system0.98241331
39MP0005248_abnormal_Harderian_gland0.97711669
40MP0000427_abnormal_hair_cycle0.97643234
41MP0005360_urolithiasis0.96515559
42MP0002108_abnormal_muscle_morphology0.95024178
43MP0010234_abnormal_vibrissa_follicle0.94834318
44MP0000653_abnormal_sex_gland0.93783335
45MP0003718_maternal_effect0.92011137
46MP0002210_abnormal_sex_determination0.88887140
47MP0003183_abnormal_peptide_metabolism0.84238009
48MP0000428_abnormal_craniofacial_morphol0.83509098
49MP0003763_abnormal_thymus_physiology0.80655672
50MP0001958_emphysema0.79645359
51MP0005171_absent_coat_pigmentation0.78438794
52MP0003890_abnormal_embryonic-extraembry0.78083566
53MP0002736_abnormal_nociception_after0.74408134
54MP0001929_abnormal_gametogenesis0.72702302
55MP0002932_abnormal_joint_morphology0.72353778
56MP0002109_abnormal_limb_morphology0.72195584
57MP0001293_anophthalmia0.71028648
58MP0001145_abnormal_male_reproductive0.70051774
59MP0000733_abnormal_muscle_development0.69388125
60MP0003698_abnormal_male_reproductive0.68754406
61MP0003936_abnormal_reproductive_system0.68193504
62MP0004130_abnormal_muscle_cell0.67807723
63MP0000569_abnormal_digit_pigmentation0.67706125
64MP0002163_abnormal_gland_morphology0.65932339
65MP0000534_abnormal_ureter_morphology0.65641789
66MP0001968_abnormal_touch/_nociception0.64361559
67MP0003935_abnormal_craniofacial_develop0.63644641
68MP0001666_abnormal_nutrient_absorption0.63229411
69MP0005395_other_phenotype0.61837291
70MP0003252_abnormal_bile_duct0.59835526
71MP0005164_abnormal_response_to0.59281773
72MP0001175_abnormal_lung_morphology0.56171869
73MP0001324_abnormal_eye_pigmentation0.55683098
74MP0005646_abnormal_pituitary_gland0.55538081
75MP0005410_abnormal_fertilization0.54770344
76MP0009703_decreased_birth_body0.53918627
77MP0002115_abnormal_skeleton_extremities0.53095674
78MP0009250_abnormal_appendicular_skeleto0.52923069
79MP0005391_vision/eye_phenotype0.52914142
80MP0004264_abnormal_extraembryonic_tissu0.52005873
81MP0000538_abnormal_urinary_bladder0.52003041
82MP0005275_abnormal_skin_tensile0.51434502
83MP0005551_abnormal_eye_electrophysiolog0.50361906
84MP0001533_abnormal_skeleton_physiology0.48679515
85MP0009115_abnormal_fat_cell0.47856087
86MP0003631_nervous_system_phenotype0.46852093
87MP0001851_eye_inflammation0.46277470
88MP0001835_abnormal_antigen_presentation0.45992100
89MP0004883_abnormal_blood_vessel0.45299902
90MP0006276_abnormal_autonomic_nervous0.45210423
91MP0002168_other_aberrant_phenotype0.44619083
92MP0003633_abnormal_nervous_system0.43598901
93MP0000163_abnormal_cartilage_morphology0.43349729
94MP0000685_abnormal_immune_system0.43319010
95MP0002161_abnormal_fertility/fecundity0.42320886
96MP0000566_synostosis0.41512778
97MP0000470_abnormal_stomach_morphology0.40728118
98MP0005503_abnormal_tendon_morphology0.40660316
99MP0002933_joint_inflammation0.40122710
100MP0005195_abnormal_posterior_eye0.39423894

Predicted human phenotypes

RankGene SetZ-score
1Neonatal short-limb short stature (HP:0008921)6.58940948
2Large earlobe (HP:0009748)6.02315824
3Flat acetabular roof (HP:0003180)5.43774171
4Vertebral clefting (HP:0008428)5.38848688
5Flat capital femoral epiphysis (HP:0003370)5.26688532
6Breech presentation (HP:0001623)4.84772469
7Hip contracture (HP:0003273)4.27849004
8Irregular epiphyses (HP:0010582)4.23430972
9Spinal cord compression (HP:0002176)4.01567711
10Symphalangism affecting the phalanges of the hand (HP:0009773)3.89455270
11Congenital stationary night blindness (HP:0007642)3.72587579
12Glucose intolerance (HP:0000833)3.66163078
13Agammaglobulinemia (HP:0004432)3.60645853
14Flattened epiphyses (HP:0003071)3.57685337
15Abnormal vertebral ossification (HP:0100569)3.57492473
16Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.54847662
17Vertebral hypoplasia (HP:0008417)3.54847662
18Short middle phalanx of finger (HP:0005819)3.53892539
19Abnormal cartilage morphology (HP:0002763)3.53181885
20Abnormality of the distal phalanx of the thumb (HP:0009617)3.48252879
21Birth length less than 3rd percentile (HP:0003561)3.42527984
22Dry hair (HP:0011359)3.40208471
23Urethral obstruction (HP:0000796)3.30918021
24Cystic hygroma (HP:0000476)3.20151178
25Tracheal stenosis (HP:0002777)3.14174487
26Scanning speech (HP:0002168)3.12014494
27Hydroureter (HP:0000072)3.09146519
28Truncal obesity (HP:0001956)3.06555947
29Limited hip movement (HP:0008800)3.03595653
30Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)3.01736187
31Visceral angiomatosis (HP:0100761)2.97324851
32Hip dysplasia (HP:0001385)2.97044267
33Abnormality of the prostate (HP:0008775)2.96800925
34Limited elbow extension (HP:0001377)2.95763398
35Mitral stenosis (HP:0001718)2.87071821
36Abnormal glucose tolerance (HP:0001952)2.83987100
37Volvulus (HP:0002580)2.80641140
38Prostate neoplasm (HP:0100787)2.79291467
39Proximal placement of thumb (HP:0009623)2.74380332
40Amelogenesis imperfecta (HP:0000705)2.74155024
41Gastrointestinal stroma tumor (HP:0100723)2.68435363
42Hemangiomatosis (HP:0007461)2.67624805
43Rhabdomyosarcoma (HP:0002859)2.62725891
44Papillary thyroid carcinoma (HP:0002895)2.61049722
45Abnormality of the middle phalanges of the hand (HP:0009833)2.61042446
46Hypoplasia of the iris (HP:0007676)2.60228837
47Recurrent bronchitis (HP:0002837)2.59086032
48Hoarse voice (HP:0001609)2.55130939
49Esophageal neoplasm (HP:0100751)2.54096176
50Neoplasm of head and neck (HP:0012288)2.54096176
51Deviation of the thumb (HP:0009603)2.47230364
52Vascular calcification (HP:0004934)2.43943971
53Proximal tubulopathy (HP:0000114)2.34536261
54Cardiovascular calcification (HP:0011915)2.33921918
55Tubulointerstitial nephritis (HP:0001970)2.32115752
56Bifid tongue (HP:0010297)2.29108841
57Anterior segment dysgenesis (HP:0007700)2.26273366
58Hypoplastic ilia (HP:0000946)2.25614705
59Stillbirth (HP:0003826)2.22527510
60Flat face (HP:0012368)2.21899676
61Lip pit (HP:0100267)2.21441867
62Hyperkalemia (HP:0002153)2.13413424
63Vertebral arch anomaly (HP:0008438)2.12813861
64Bronchitis (HP:0012387)2.12351173
65Neoplasm of the small intestine (HP:0100833)2.11809828
66Supernumerary spleens (HP:0009799)2.10947019
67Chronic sinusitis (HP:0011109)2.07980411
68Persistence of primary teeth (HP:0006335)2.07178002
69Neoplasm of the rectum (HP:0100743)2.07025599
70Hypoplastic ischia (HP:0003175)2.05043905
71Patellar aplasia (HP:0006443)2.01092165
72Premature skin wrinkling (HP:0100678)1.99080142
73Abnormality of the acetabulum (HP:0003170)1.97002714
74Decreased circulating renin level (HP:0003351)1.96323962
75Radial bowing (HP:0002986)1.93363613
76Abnormality of male internal genitalia (HP:0000022)1.92803572
77Abnormality of the epiphyses of the hand (HP:0005924)1.91537460
78Neoplasm of striated muscle (HP:0009728)1.89542038
79Hyperactive renin-angiotensin system (HP:0000841)1.88867089
80Abnormality of transition element cation homeostasis (HP:0011030)1.87492203
81Aplasia/Hypoplasia of the patella (HP:0006498)1.85404420
82Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.83607852
83Impulsivity (HP:0100710)1.81424245
84Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.81135671
85Sandal gap (HP:0001852)1.80209647
86Thickened nuchal skin fold (HP:0000474)1.79476092
87Abnormality of the epiphysis of the femoral head (HP:0010574)1.79279364
88Abnormality of the proximal phalanges of the hand (HP:0009834)1.77319118
89Abnormality of the ischium (HP:0003174)1.77000206
90Overfolded helix (HP:0000396)1.76400285
91Enlarged epiphyses (HP:0010580)1.73719709
92Abnormality of the middle phalanges of the toes (HP:0010183)1.72005584
93Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.69462185
94Duplication of thumb phalanx (HP:0009942)1.69060374
95Chin dimple (HP:0010751)1.68082234
96Cutaneous finger syndactyly (HP:0010554)1.67575185
97Cerebral aneurysm (HP:0004944)1.66947671
98Broad metatarsal (HP:0001783)1.66816790
99Woolly hair (HP:0002224)1.65027346
100Constricted visual fields (HP:0001133)1.64623492

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K99.01712924
2TESK26.36990103
3GRK13.58514435
4MARK13.44573803
5TAF13.14133895
6PDK23.07843753
7PIK3CA2.75253952
8NLK2.66632477
9CSNK1G12.53503697
10MAP3K132.42396049
11PDGFRA2.27771476
12ACVR1B2.15249145
13PIK3CG2.13105286
14CASK1.98852798
15CSNK1G31.95528756
16CSNK1G21.62913458
17NEK61.51605678
18PNCK1.45156901
19PDGFRB1.37280650
20FRK1.27619916
21ARAF1.22269364
22SGK21.20333355
23DDR21.17780622
24BMPR1B1.17575708
25AKT31.13150900
26JAK11.12402055
27CDC42BPA1.09892176
28MAPKAPK31.06388992
29TRPM71.01748301
30CAMK1G1.01437191
31MELK0.99635312
32PBK0.96521147
33NME10.90822345
34EIF2AK30.90038675
35ZAK0.89832411
36MARK30.89824347
37SGK4940.84577793
38SGK2230.84577793
39FGFR20.83439481
40CHEK20.78576369
41KSR20.76394171
42NEK90.66828402
43SGK30.64030970
44MAP3K70.62039483
45BRSK20.59484130
46NTRK30.59227841
47NTRK20.56095600
48RET0.54523255
49MOS0.51399421
50TAOK30.48537004
51MAP2K10.48295908
52CAMK40.46605802
53BRAF0.41302322
54MST1R0.40166115
55MAPKAPK50.35955666
56TYRO30.35898940
57TGFBR10.35405029
58CSNK1D0.32908267
59DYRK1A0.32640229
60CAMK1D0.32175788
61INSRR0.31648715
62MAP3K20.30942217
63MAPK70.29970172
64ADRBK20.29284571
65RPS6KB10.28559057
66RPS6KA60.27615330
67AURKB0.24732898
68CDK90.23305149
69MET0.23238428
70MAPK40.21382571
71FGFR30.21131542
72CDK70.20568345
73AURKA0.20485120
74MAP3K40.20342107
75PDPK10.20338477
76KSR10.19821626
77MATK0.19407333
78MST40.18236691
79CSNK1A10.17015558
80MAPK120.16229628
81CAMKK20.15942606
82SGK10.15036585
83PRKCQ0.12746964
84CAMK2A0.12446246
85PDK10.12250012
86FER0.11561479
87CSNK1E0.10915186
88ADRBK10.10775618
89JAK20.10252222
90PAK10.09940241
91PRKACA0.09807065
92PRKACG0.08590453
93CSNK2A20.08491090
94LATS10.08178753
95GSK3A0.08172978
96PRKCA0.07803393
97EPHA30.07487439
98RAF10.07328286
99WNK30.07323187
100UHMK10.07241467

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007709.85406300
2Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007606.36460566
3Starch and sucrose metabolism_Homo sapiens_hsa005002.92873637
4Fatty acid biosynthesis_Homo sapiens_hsa000612.49730985
5Histidine metabolism_Homo sapiens_hsa003402.12234986
6Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.05158657
7Selenocompound metabolism_Homo sapiens_hsa004502.02386274
8Sulfur metabolism_Homo sapiens_hsa009201.93604882
9Tryptophan metabolism_Homo sapiens_hsa003801.81718998
10Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.76346412
11Phototransduction_Homo sapiens_hsa047441.50681839
12Ovarian steroidogenesis_Homo sapiens_hsa049131.49230675
13Melanoma_Homo sapiens_hsa052181.46201669
14One carbon pool by folate_Homo sapiens_hsa006701.30344393
15African trypanosomiasis_Homo sapiens_hsa051431.21683621
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.20200251
17Circadian rhythm_Homo sapiens_hsa047101.15467484
18Propanoate metabolism_Homo sapiens_hsa006401.12878890
19Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.11642083
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10676428
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08267628
22Mineral absorption_Homo sapiens_hsa049781.01967020
23Prostate cancer_Homo sapiens_hsa052151.01479130
24Cocaine addiction_Homo sapiens_hsa050300.95105664
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93950643
26Glioma_Homo sapiens_hsa052140.90983881
27Basal transcription factors_Homo sapiens_hsa030220.90855430
28Long-term depression_Homo sapiens_hsa047300.87296450
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85965448
30Oocyte meiosis_Homo sapiens_hsa041140.81210318
31Phenylalanine metabolism_Homo sapiens_hsa003600.79278322
32Fanconi anemia pathway_Homo sapiens_hsa034600.76537608
33Dorso-ventral axis formation_Homo sapiens_hsa043200.76122023
34Serotonergic synapse_Homo sapiens_hsa047260.76078793
35Purine metabolism_Homo sapiens_hsa002300.75628787
36ABC transporters_Homo sapiens_hsa020100.75401318
37FoxO signaling pathway_Homo sapiens_hsa040680.74854982
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73481268
39Complement and coagulation cascades_Homo sapiens_hsa046100.73142956
40Intestinal immune network for IgA production_Homo sapiens_hsa046720.73078791
41TGF-beta signaling pathway_Homo sapiens_hsa043500.71243744
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70785459
43Dilated cardiomyopathy_Homo sapiens_hsa054140.69799951
44Glycerolipid metabolism_Homo sapiens_hsa005610.67366691
45Tyrosine metabolism_Homo sapiens_hsa003500.65435765
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63283729
47Nitrogen metabolism_Homo sapiens_hsa009100.61631119
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.61374812
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60462997
50Taste transduction_Homo sapiens_hsa047420.58634574
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56023559
52ECM-receptor interaction_Homo sapiens_hsa045120.52711433
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52568885
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.52563575
55Amoebiasis_Homo sapiens_hsa051460.52481754
56mTOR signaling pathway_Homo sapiens_hsa041500.47676313
57p53 signaling pathway_Homo sapiens_hsa041150.47101541
58Retinol metabolism_Homo sapiens_hsa008300.46350096
59Focal adhesion_Homo sapiens_hsa045100.44252977
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41838012
61Linoleic acid metabolism_Homo sapiens_hsa005910.41631092
62Protein digestion and absorption_Homo sapiens_hsa049740.40831511
63Hematopoietic cell lineage_Homo sapiens_hsa046400.40254654
64Proteoglycans in cancer_Homo sapiens_hsa052050.39077408
65Thyroid cancer_Homo sapiens_hsa052160.38335199
66beta-Alanine metabolism_Homo sapiens_hsa004100.37920587
67Renin-angiotensin system_Homo sapiens_hsa046140.36353637
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.36018015
69Fatty acid degradation_Homo sapiens_hsa000710.32224062
70Amphetamine addiction_Homo sapiens_hsa050310.31249556
71Olfactory transduction_Homo sapiens_hsa047400.31066748
72Hedgehog signaling pathway_Homo sapiens_hsa043400.30591537
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29250078
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.27908272
75Arginine and proline metabolism_Homo sapiens_hsa003300.27674464
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.25799333
77Caffeine metabolism_Homo sapiens_hsa002320.25370845
78Chemical carcinogenesis_Homo sapiens_hsa052040.24999499
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24731473
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24529072
81Gap junction_Homo sapiens_hsa045400.24517555
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24412711
83Calcium signaling pathway_Homo sapiens_hsa040200.23501199
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23335619
85Butanoate metabolism_Homo sapiens_hsa006500.21531577
86Glutamatergic synapse_Homo sapiens_hsa047240.21495059
87Asthma_Homo sapiens_hsa053100.21297960
88Sphingolipid metabolism_Homo sapiens_hsa006000.21285306
89Pathways in cancer_Homo sapiens_hsa052000.20723313
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20444023
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20314411
92Adherens junction_Homo sapiens_hsa045200.19878789
93Prolactin signaling pathway_Homo sapiens_hsa049170.18032994
94Small cell lung cancer_Homo sapiens_hsa052220.17976449
95Nicotine addiction_Homo sapiens_hsa050330.17687574
96Platelet activation_Homo sapiens_hsa046110.17637734
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17501071
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17397216
99Homologous recombination_Homo sapiens_hsa034400.16612265
100Inositol phosphate metabolism_Homo sapiens_hsa005620.16347855

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