MMP27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mast cell activation (GO:0033005)6.57282226
2production of molecular mediator involved in inflammatory response (GO:0002532)6.23772307
3positive regulation of mast cell activation involved in immune response (GO:0033008)6.17089961
4positive regulation of mast cell degranulation (GO:0043306)6.17089961
5neutrophil activation involved in immune response (GO:0002283)5.96442644
6positive regulation by symbiont of host defense response (GO:0052509)5.53816164
7modulation by symbiont of host defense response (GO:0052031)5.53816164
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.53816164
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.53816164
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.53816164
11modulation by symbiont of host immune response (GO:0052553)5.53816164
12regulation of interferon-beta biosynthetic process (GO:0045357)5.15371752
13positive regulation of myeloid leukocyte mediated immunity (GO:0002888)5.10334396
14regulation of mast cell degranulation (GO:0043304)5.09815863
15neutrophil mediated immunity (GO:0002446)5.09527132
16positive regulation of leukocyte degranulation (GO:0043302)4.93410603
17regulation of mast cell activation involved in immune response (GO:0033006)4.78401591
18regulation of mast cell activation (GO:0033003)4.50548638
19positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.42411089
20regulation of B cell receptor signaling pathway (GO:0050855)4.29479071
21detection of other organism (GO:0098543)4.23582227
22respiratory burst (GO:0045730)4.21317740
23leukocyte aggregation (GO:0070486)4.17066191
24cellular extravasation (GO:0045123)4.10130062
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.07129658
26leukocyte migration involved in inflammatory response (GO:0002523)4.06917997
27macrophage activation involved in immune response (GO:0002281)4.03294678
28regulation of myeloid leukocyte mediated immunity (GO:0002886)4.01682376
29regulation of leukocyte degranulation (GO:0043300)3.97905037
30detection of bacterium (GO:0016045)3.97215794
31myeloid leukocyte mediated immunity (GO:0002444)3.95711903
32low-density lipoprotein particle clearance (GO:0034383)3.89023142
33response to peptidoglycan (GO:0032494)3.81476805
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.80516534
35response to host immune response (GO:0052572)3.80516534
36granulocyte activation (GO:0036230)3.78255394
37regulation of cholesterol storage (GO:0010885)3.69894401
38myeloid cell activation involved in immune response (GO:0002275)3.66636213
39plasma lipoprotein particle clearance (GO:0034381)3.60974108
40response to host (GO:0075136)3.59368407
41response to host defenses (GO:0052200)3.59368407
42response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.59368407
43positive regulation of interferon-alpha production (GO:0032727)3.59256606
44neutrophil activation (GO:0042119)3.59022287
45immunoglobulin mediated immune response (GO:0016064)3.41106686
46regulation of interferon-alpha production (GO:0032647)3.40721135
47killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.34539612
48disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.34539612
49positive regulation of regulated secretory pathway (GO:1903307)3.31252592
50positive regulation of cellular amide metabolic process (GO:0034250)3.25047799
51leukotriene metabolic process (GO:0006691)3.23866408
52regulation of regulated secretory pathway (GO:1903305)3.18678454
53leukocyte degranulation (GO:0043299)3.14043176
54regulation of T-helper 1 cell differentiation (GO:0045625)3.11216686
55leukotriene biosynthetic process (GO:0019370)3.10805638
56plasma lipoprotein particle assembly (GO:0034377)3.06564157
57regulation of hypersensitivity (GO:0002883)3.04783021
58detection of external biotic stimulus (GO:0098581)3.04689015
59defense response to fungus (GO:0050832)3.04140996
60cytokine secretion (GO:0050663)3.03611819
61positive regulation of antigen processing and presentation (GO:0002579)3.03398450
62negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.03335075
63negative regulation of cell killing (GO:0031342)3.03335075
64I-kappaB phosphorylation (GO:0007252)3.02420673
65pinocytosis (GO:0006907)2.99705808
66detection of biotic stimulus (GO:0009595)2.95138901
67regulation of interleukin-8 biosynthetic process (GO:0045414)2.95113171
68natural killer cell mediated cytotoxicity (GO:0042267)2.94896401
69natural killer cell mediated immunity (GO:0002228)2.94896401
70very-low-density lipoprotein particle assembly (GO:0034379)2.94530877
71protein-lipid complex assembly (GO:0065005)2.94182786
72triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.92457461
73response to fungus (GO:0009620)2.92221519
74Arp2/3 complex-mediated actin nucleation (GO:0034314)2.91133163
75peptidyl-glutamic acid carboxylation (GO:0017187)2.90339353
76protein carboxylation (GO:0018214)2.90339353
77leukocyte mediated cytotoxicity (GO:0001909)2.88435758
78hydrogen peroxide biosynthetic process (GO:0050665)2.88076055
79positive regulation of hemostasis (GO:1900048)2.86576695
80positive regulation of blood coagulation (GO:0030194)2.86576695
81positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.85274509
82positive regulation of p38MAPK cascade (GO:1900745)2.84728961
83actin nucleation (GO:0045010)2.84080556
84microglial cell activation (GO:0001774)2.79509092
85positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.78152087
86positive regulation of coagulation (GO:0050820)2.75766924
87negative regulation of mast cell activation (GO:0033004)2.75214090
88macrophage activation (GO:0042116)2.73237153
89sequestering of metal ion (GO:0051238)2.73067275
90positive regulation of lipid storage (GO:0010884)2.71900066
91killing of cells of other organism (GO:0031640)2.69069932
92disruption of cells of other organism (GO:0044364)2.69069932
93regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.68372931
94lipopolysaccharide-mediated signaling pathway (GO:0031663)2.65411600
95positive regulation of interferon-beta production (GO:0032728)2.64068326
96reactive oxygen species biosynthetic process (GO:1903409)2.63210049
97positive regulation of acute inflammatory response (GO:0002675)2.62854380
98lipoprotein transport (GO:0042953)2.62690363
99positive regulation of gamma-delta T cell activation (GO:0046645)2.62536697
100regulation of phagocytosis (GO:0050764)2.60040234

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.97756837
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.52961252
3* BP1_19119308_ChIP-ChIP_Hs578T_Human4.50612100
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.07434991
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.04164218
6* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.01059022
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.75633353
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.45356105
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.40722223
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.36988941
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.90400362
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.72326733
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.65048445
14BRD4_27068464_Chip-Seq_AML-cells_Mouse2.53906382
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.43320372
16SCL_19346495_ChIP-Seq_HPC-7_Human2.43138540
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31597667
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23658901
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.18529122
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.11897626
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.11509358
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09369360
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.97859799
24SPI1_23547873_ChIP-Seq_NB4_Human1.96842254
25VDR_24763502_ChIP-Seq_THP-1_Human1.95072019
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93668777
27VDR_24787735_ChIP-Seq_THP-1_Human1.92969273
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92958510
29PU_27001747_Chip-Seq_BMDM_Mouse1.90789650
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.89907336
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.87604051
32SPI1_23127762_ChIP-Seq_K562_Human1.87114118
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87073033
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80621261
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.80204909
36GATA1_22025678_ChIP-Seq_K562_Human1.79945086
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79289005
38* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.73072590
39PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67986576
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66717584
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65915139
42* RUNX1_22412390_ChIP-Seq_EML_Mouse1.64683820
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.63970384
44VDR_21846776_ChIP-Seq_THP-1_Human1.62311470
45* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.53699703
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.51701041
47* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49387602
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46212677
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41955975
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39326177
51* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38902637
52MAF_26560356_Chip-Seq_TH1_Human1.33586886
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32609695
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31487116
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31463914
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30759171
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30696353
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29487518
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29120418
60GATA1_19941826_ChIP-Seq_K562_Human1.27071088
61RUNX_20019798_ChIP-Seq_JUKART_Human1.23627419
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22607274
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21176317
64MYB_26560356_Chip-Seq_TH2_Human1.20622191
65EGR1_19032775_ChIP-ChIP_M12_Human1.18248911
66* GATA1_19941827_ChIP-Seq_MEL_Mouse1.18242649
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15800104
68GATA2_19941826_ChIP-Seq_K562_Human1.15422685
69GATA3_26560356_Chip-Seq_TH2_Human1.13983667
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13138347
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12706869
72MYB_26560356_Chip-Seq_TH1_Human1.09651512
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08322060
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07484594
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07481705
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06276935
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05881924
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.05820265
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04334415
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.01535714
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00514237
82ELK3_25401928_ChIP-Seq_HUVEC_Human0.97485997
83SPI1_20517297_ChIP-Seq_HL60_Human0.96164271
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95830390
85TCF7_22412390_ChIP-Seq_EML_Mouse0.93898519
86UTX_26944678_Chip-Seq_JUKART_Human0.92757044
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90866864
88PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90171021
89LXR_22292898_ChIP-Seq_THP-1_Human0.85474746
90GATA3_27048872_Chip-Seq_THYMUS_Human0.85215108
91SOX2_20726797_ChIP-Seq_SW620_Human0.84576654
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84396994
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84298161
94NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83794368
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83794368
96SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82830793
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82463523
98ESR1_21235772_ChIP-Seq_MCF-7_Human0.79810466
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77475575
100TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.74636020

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.82250042
2MP0003436_decreased_susceptibility_to3.66170524
3MP0000569_abnormal_digit_pigmentation3.17236961
4MP0002138_abnormal_hepatobiliary_system3.10742563
5MP0002419_abnormal_innate_immunity3.01133338
6MP0001835_abnormal_antigen_presentation2.99964985
7MP0003724_increased_susceptibility_to2.95378580
8MP0009840_abnormal_foam_cell2.94147114
9MP0003303_peritoneal_inflammation2.76799302
10MP0009278_abnormal_bone_marrow2.73867742
11MP0002148_abnormal_hypersensitivity_rea2.60683728
12MP0009785_altered_susceptibility_to2.58865208
13MP0003172_abnormal_lysosome_physiology2.49629079
14MP0005000_abnormal_immune_tolerance2.41612121
15MP0005025_abnormal_response_to2.34053717
16MP0006082_CNS_inflammation2.33140557
17MP0002139_abnormal_hepatobiliary_system2.30148074
18MP0001790_abnormal_immune_system2.20071936
19MP0005387_immune_system_phenotype2.20071936
20MP0005464_abnormal_platelet_physiology2.11534533
21MP0000685_abnormal_immune_system2.11179344
22MP0001533_abnormal_skeleton_physiology2.05875501
23MP0003300_gastrointestinal_ulcer2.04459166
24MP0000604_amyloidosis2.03672179
25MP0005360_urolithiasis2.01216875
26MP0002452_abnormal_antigen_presenting2.00346420
27MP0001800_abnormal_humoral_immune1.99596168
28MP0002723_abnormal_immune_serum1.89912651
29MP0000343_altered_response_to1.86086738
30MP0001819_abnormal_immune_cell1.74978442
31MP0008438_abnormal_cutaneous_collagen1.73721020
32MP0005174_abnormal_tail_pigmentation1.73354410
33MP0002420_abnormal_adaptive_immunity1.73341527
34MP0003690_abnormal_glial_cell1.69369730
35MP0003191_abnormal_cellular_cholesterol1.68076469
36MP0001845_abnormal_inflammatory_respons1.66991362
37MP0005397_hematopoietic_system_phenotyp1.64920633
38MP0001545_abnormal_hematopoietic_system1.64920633
39MP0003566_abnormal_cell_adhesion1.63273167
40MP0004947_skin_inflammation1.60222392
41MP0000465_gastrointestinal_hemorrhage1.60036312
42MP0002277_abnormal_respiratory_mucosa1.59847610
43MP0003075_altered_response_to1.56870561
44MP0001958_emphysema1.54611476
45MP0005365_abnormal_bile_salt1.52724387
46MP0008469_abnormal_protein_level1.51440128
47MP0001853_heart_inflammation1.46583285
48MP0009764_decreased_sensitivity_to1.45817328
49MP0005083_abnormal_biliary_tract1.44755884
50MP0002405_respiratory_system_inflammati1.43991420
51MP0003448_altered_tumor_morphology1.43407464
52MP0010329_abnormal_lipoprotein_level1.40886628
53MP0003806_abnormal_nucleotide_metabolis1.39777139
54MP0005164_abnormal_response_to1.25096069
55MP0005085_abnormal_gallbladder_physiolo1.24811937
56MP0009763_increased_sensitivity_to1.20597445
57MP0005257_abnormal_intraocular_pressure1.20357831
58MP0008875_abnormal_xenobiotic_pharmacok1.19791569
59MP0003252_abnormal_bile_duct1.19443209
60MP0002933_joint_inflammation1.17511202
61MP0000858_altered_metastatic_potential1.15908267
62MP0004510_myositis1.14384357
63MP0000716_abnormal_immune_system1.13055588
64MP0000689_abnormal_spleen_morphology1.13010869
65MP0003656_abnormal_erythrocyte_physiolo1.10918424
66MP0005166_decreased_susceptibility_to1.10217085
67MP0005167_abnormal_blood-brain_barrier1.06885031
68MP0004883_abnormal_blood_vessel1.06095360
69MP0000609_abnormal_liver_physiology1.05081348
70MP0003279_aneurysm1.01964314
71MP0003183_abnormal_peptide_metabolism1.00016610
72MP0005408_hypopigmentation0.99835822
73MP0005023_abnormal_wound_healing0.98133135
74MP0002166_altered_tumor_susceptibility0.97063368
75MP0002398_abnormal_bone_marrow0.96763888
76MP0005390_skeleton_phenotype0.96590773
77MP0005451_abnormal_body_composition0.96472512
78MP0003705_abnormal_hypodermis_morpholog0.92284040
79MP0000767_abnormal_smooth_muscle0.92105014
80MP0002429_abnormal_blood_cell0.91478603
81MP0002998_abnormal_bone_remodeling0.91160030
82MP0005671_abnormal_response_to0.89948077
83MP0001764_abnormal_homeostasis0.89564901
84MP0002722_abnormal_immune_system0.88240390
85MP0008260_abnormal_autophagy0.87684368
86MP0002254_reproductive_system_inflammat0.87642184
87MP0001243_abnormal_dermal_layer0.87010855
88MP0010155_abnormal_intestine_physiology0.85788506
89MP0001851_eye_inflammation0.85207548
90MP0005310_abnormal_salivary_gland0.84988547
91MP0000249_abnormal_blood_vessel0.81163729
92MP0004019_abnormal_vitamin_homeostasis0.80367152
93MP0002118_abnormal_lipid_homeostasis0.79422787
94MP0005332_abnormal_amino_acid0.77660574
95MP0005319_abnormal_enzyme/_coenzyme0.77619426
96MP0000015_abnormal_ear_pigmentation0.74742527
97MP0003195_calcinosis0.74328723
98MP0000371_diluted_coat_color0.69734956
99MP0005584_abnormal_enzyme/coenzyme_acti0.68892783
100MP0000598_abnormal_liver_morphology0.68869897

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.61470663
2Recurrent bacterial skin infections (HP:0005406)6.37114452
3Vacuolated lymphocytes (HP:0001922)5.40137488
4Recurrent gram-negative bacterial infections (HP:0005420)5.34667563
5Spontaneous hematomas (HP:0007420)5.29213133
6Eczematoid dermatitis (HP:0000976)5.27039202
7Increased cerebral lipofuscin (HP:0011813)5.08900110
8Abnormality of macrophages (HP:0004311)4.41275129
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.37970567
10Systemic lupus erythematosus (HP:0002725)4.31497921
11Hematochezia (HP:0002573)4.22618592
12Joint hemorrhage (HP:0005261)3.88590169
13Glomerulonephritis (HP:0000099)3.86692417
14Autoimmune thrombocytopenia (HP:0001973)3.77085471
15Gingival bleeding (HP:0000225)3.74772892
16Gingivitis (HP:0000230)3.60741052
17Deep venous thrombosis (HP:0002625)3.59104866
18Stomatitis (HP:0010280)3.58632023
19Recurrent skin infections (HP:0001581)3.55038654
20Obstructive lung disease (HP:0006536)3.50455104
21Chronic obstructive pulmonary disease (HP:0006510)3.50455104
22Urticaria (HP:0001025)3.40519816
23Conjunctival telangiectasia (HP:0000524)3.35926447
24Mediastinal lymphadenopathy (HP:0100721)3.34899753
25Myositis (HP:0100614)3.34743110
26Prostate neoplasm (HP:0100787)3.27480005
27Dysostosis multiplex (HP:0000943)3.26640229
28Complement deficiency (HP:0004431)3.24312415
29Abnormality of the vasculature of the conjunctiva (HP:0008054)3.20101224
30Axonal loss (HP:0003447)3.09339732
31Myocardial infarction (HP:0001658)2.98492466
32Urinary glycosaminoglycan excretion (HP:0003541)2.92337110
33Mucopolysacchariduria (HP:0008155)2.92337110
34Elevated erythrocyte sedimentation rate (HP:0003565)2.90736024
35Amyloidosis (HP:0011034)2.88430794
36Xanthomatosis (HP:0000991)2.83826407
37Abnormality of complement system (HP:0005339)2.83162591
38Abnormality of polysaccharide metabolism (HP:0011012)2.82720797
39Abnormality of glycosaminoglycan metabolism (HP:0004371)2.82720797
40Abnormality of mucopolysaccharide metabolism (HP:0011020)2.82720797
41Loss of speech (HP:0002371)2.81177964
42Epistaxis (HP:0000421)2.80656534
43Periodontitis (HP:0000704)2.78615271
44Menorrhagia (HP:0000132)2.64996605
45Global brain atrophy (HP:0002283)2.64415898
46Pustule (HP:0200039)2.64044535
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.63940266
48Orchitis (HP:0100796)2.61380334
49Abnormality of glycolipid metabolism (HP:0010969)2.61294720
50Abnormality of liposaccharide metabolism (HP:0010968)2.61294720
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.61294720
52Nephritis (HP:0000123)2.51781194
53Hepatosplenomegaly (HP:0001433)2.51462380
54Esophageal varix (HP:0002040)2.50867527
55Cellulitis (HP:0100658)2.50852721
56Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.50112294
57Disinhibition (HP:0000734)2.47995011
58Pulmonary embolism (HP:0002204)2.47598346
59Recurrent fungal infections (HP:0002841)2.43120191
60Hypercholesterolemia (HP:0003124)2.40963786
61Prolonged bleeding time (HP:0003010)2.39891768
62Abnormal platelet volume (HP:0011876)2.34088540
63Thick nail (HP:0001805)2.28726167
64Abnormality of the common coagulation pathway (HP:0010990)2.26196778
65Vasculitis (HP:0002633)2.24262759
66Upper motor neuron abnormality (HP:0002127)2.21804266
67Generalized aminoaciduria (HP:0002909)2.19218934
68Pathologic fracture (HP:0002756)2.18935938
69Impaired platelet aggregation (HP:0003540)2.18797815
70Abnormal platelet function (HP:0011869)2.18797815
71Thoracic kyphosis (HP:0002942)2.17532282
72Abnormality of monocarboxylic acid metabolism (HP:0010996)2.16886715
73Prolonged partial thromboplastin time (HP:0003645)2.12433624
74Microcytic anemia (HP:0001935)2.10068251
75Polycythemia (HP:0001901)2.08931338
76Poor head control (HP:0002421)2.03208104
77Spondylolisthesis (HP:0003302)2.02408116
78Peripheral demyelination (HP:0011096)2.01799191
79Meningitis (HP:0001287)2.00262347
80Increased mean platelet volume (HP:0011877)1.99908540
81Cerebral hemorrhage (HP:0001342)1.99572291
82Retrobulbar optic neuritis (HP:0100654)1.98914921
83Optic neuritis (HP:0100653)1.98914921
84Petechiae (HP:0000967)1.98203611
85Osteomyelitis (HP:0002754)1.96626252
86Osteolytic defects of the phalanges of the hand (HP:0009771)1.96363450
87Osteolytic defects of the hand bones (HP:0009699)1.96363450
88Abnormality of the prostate (HP:0008775)1.96000272
89Bruising susceptibility (HP:0000978)1.94900249
90Vertebral compression fractures (HP:0002953)1.93847804
91Purpura (HP:0000979)1.93669709
92Leukocytosis (HP:0001974)1.92194832
93Abnormality of the nasal mucosa (HP:0000433)1.90210811
94Hypophosphatemia (HP:0002148)1.87817272
95Intrahepatic cholestasis (HP:0001406)1.87402102
96Inflammation of the large intestine (HP:0002037)1.86848678
97Abnormality of iron homeostasis (HP:0011031)1.85986908
98Hypophosphatemic rickets (HP:0004912)1.85156420
99Hyperlipoproteinemia (HP:0010980)1.84799705
100Mucosal telangiectasiae (HP:0100579)1.82120138

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.09697689
2RIPK43.96922296
3ERN13.54797247
4IRAK43.23939426
5KIT2.96876646
6CSK2.75056482
7FGR2.68653536
8MAP3K142.68436718
9TYK22.64387404
10IRAK32.52085811
11TEC2.50648513
12TBK12.32699224
13BTK1.90155430
14EPHB11.87697901
15RIPK11.86520544
16TAOK31.85066863
17ZAP701.76055893
18FES1.72958165
19ITK1.71033364
20MAP4K11.57151198
21TGFBR21.57099036
22HCK1.55767599
23JAK11.54832692
24CAMK1D1.54272652
25TRPM71.51975274
26IKBKE1.39392484
27TXK1.35861646
28STK101.32663403
29PTK21.26995356
30MAP2K31.26256655
31TRIB31.21563158
32SYK1.18740043
33PTK61.16971255
34TTN1.16617071
35LYN1.16482135
36DAPK21.14344520
37PIK3CG1.12063877
38MATK1.11114126
39JAK21.10348489
40IKBKB1.10183956
41SIK21.07604801
42YES11.04395076
43CDK91.04042575
44JAK30.99888989
45LCK0.99515846
46CSF1R0.99435014
47MAP3K130.97048756
48FYN0.91669703
49NEK90.91041578
50CAMK1G0.88052439
51RPS6KA40.82939487
52CDK60.78845854
53MAPK110.78328064
54BCKDK0.77433898
55EGFR0.74888685
56EIF2AK20.72300808
57PKN20.72080524
58NME20.72047467
59MAP3K70.71327186
60MST40.70302197
61MAPKAPK20.67803531
62BMX0.67505814
63LRRK20.66220803
64ABL10.66082174
65MST1R0.66043174
66IGF1R0.65123421
67KDR0.61850027
68FGFR40.61406994
69BMPR20.60868055
70ERBB30.60471984
71CLK10.59875692
72MAPK120.59067955
73PRKCD0.57805100
74SIK10.57002373
75MAP3K10.54161741
76PIM20.52359426
77GRK60.51357355
78MAP2K60.50863620
79DMPK0.50415893
80PAK40.49597817
81PRKCQ0.47656265
82PIM10.47017350
83CHUK0.46714467
84MOS0.46558306
85SCYL20.46422854
86TNK20.45108148
87STK240.45087055
88MAP3K110.43530640
89MAP3K60.42665077
90MAP3K100.41838225
91ABL20.41100422
92PRKG20.40723191
93MARK30.40395718
94CDK120.39667877
95CSNK1A1L0.38628805
96SRC0.34190707
97PDPK10.33778149
98CSNK1G10.32491656
99RPS6KA20.32249288
100CSNK1G30.31805605

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.16658245
2Leishmaniasis_Homo sapiens_hsa051402.61682390
3Complement and coagulation cascades_Homo sapiens_hsa046102.60602661
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.58417922
5Lysosome_Homo sapiens_hsa041422.51572357
6Asthma_Homo sapiens_hsa053102.48233333
7Caffeine metabolism_Homo sapiens_hsa002322.39712195
8Osteoclast differentiation_Homo sapiens_hsa043802.02700153
9Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96712467
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.94227869
11Other glycan degradation_Homo sapiens_hsa005111.94008855
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89896242
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.87663825
14Pertussis_Homo sapiens_hsa051331.80783535
15Phagosome_Homo sapiens_hsa041451.72684636
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70348431
17Tuberculosis_Homo sapiens_hsa051521.67155565
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.64795711
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56554072
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48765596
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45990327
22Malaria_Homo sapiens_hsa051441.45900740
23Renin-angiotensin system_Homo sapiens_hsa046141.42580831
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37521253
25Arginine biosynthesis_Homo sapiens_hsa002201.34671179
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30945922
27Measles_Homo sapiens_hsa051621.28240000
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24314125
29Nitrogen metabolism_Homo sapiens_hsa009101.24212990
30Rheumatoid arthritis_Homo sapiens_hsa053231.23397671
31B cell receptor signaling pathway_Homo sapiens_hsa046621.20549062
32Shigellosis_Homo sapiens_hsa051311.17714240
33Histidine metabolism_Homo sapiens_hsa003401.16500054
34Toxoplasmosis_Homo sapiens_hsa051451.12282940
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09858704
36TNF signaling pathway_Homo sapiens_hsa046681.09115464
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08730914
38Influenza A_Homo sapiens_hsa051641.07535904
39Tryptophan metabolism_Homo sapiens_hsa003801.06367315
40Legionellosis_Homo sapiens_hsa051341.05312691
41Hematopoietic cell lineage_Homo sapiens_hsa046401.02503395
42Retinol metabolism_Homo sapiens_hsa008301.02313600
43PPAR signaling pathway_Homo sapiens_hsa033201.01969459
44Salmonella infection_Homo sapiens_hsa051321.01238081
45Allograft rejection_Homo sapiens_hsa053301.01131276
46Starch and sucrose metabolism_Homo sapiens_hsa005001.00210522
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98963621
48Chemokine signaling pathway_Homo sapiens_hsa040620.98774433
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97107676
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95432747
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.93988053
52Apoptosis_Homo sapiens_hsa042100.93691863
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93469077
54Chemical carcinogenesis_Homo sapiens_hsa052040.86964421
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.85390462
56Graft-versus-host disease_Homo sapiens_hsa053320.83438865
57Hepatitis C_Homo sapiens_hsa051600.82631527
58ABC transporters_Homo sapiens_hsa020100.79536668
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78926730
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.78597914
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77510454
62Amoebiasis_Homo sapiens_hsa051460.77357540
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77290184
64Fatty acid degradation_Homo sapiens_hsa000710.76423635
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.73842458
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72496899
67Peroxisome_Homo sapiens_hsa041460.67648230
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66773148
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.65261426
70Hepatitis B_Homo sapiens_hsa051610.64725324
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62670873
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62413203
73Steroid biosynthesis_Homo sapiens_hsa001000.57820973
74Viral myocarditis_Homo sapiens_hsa054160.57799857
75Platelet activation_Homo sapiens_hsa046110.55793679
76Herpes simplex infection_Homo sapiens_hsa051680.53598219
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.53433481
78Antigen processing and presentation_Homo sapiens_hsa046120.52767813
79Fatty acid metabolism_Homo sapiens_hsa012120.50930075
80beta-Alanine metabolism_Homo sapiens_hsa004100.50928475
81African trypanosomiasis_Homo sapiens_hsa051430.50543118
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.50397779
83Fat digestion and absorption_Homo sapiens_hsa049750.50251530
84Glycerolipid metabolism_Homo sapiens_hsa005610.48370606
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48349791
86Fatty acid elongation_Homo sapiens_hsa000620.48267703
87Phenylalanine metabolism_Homo sapiens_hsa003600.48180897
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46972787
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44202835
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40363892
91Insulin resistance_Homo sapiens_hsa049310.40216927
92Autoimmune thyroid disease_Homo sapiens_hsa053200.39928929
93Pancreatic cancer_Homo sapiens_hsa052120.36769462
94Endocytosis_Homo sapiens_hsa041440.34859023
95Chronic myeloid leukemia_Homo sapiens_hsa052200.34853697
96Lysine degradation_Homo sapiens_hsa003100.34431479
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33510596
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.33223509
99Prion diseases_Homo sapiens_hsa050200.32381855
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31799891

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