MMP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060527.58344200
2regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)7.04048496
3artery development (GO:0060840)6.82200562
4lung lobe morphogenesis (GO:0060463)6.82074633
5transepithelial transport (GO:0070633)6.80777904
6prostate gland epithelium morphogenesis (GO:0060740)6.64459510
7COPI coating of Golgi vesicle (GO:0048205)6.57832773
8Golgi transport vesicle coating (GO:0048200)6.57832773
9fucose catabolic process (GO:0019317)6.28023184
10L-fucose metabolic process (GO:0042354)6.28023184
11L-fucose catabolic process (GO:0042355)6.28023184
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.92773145
13epithelial cell differentiation involved in prostate gland development (GO:0060742)5.90578666
14mannose metabolic process (GO:0006013)5.85612248
15mitotic cell cycle arrest (GO:0071850)5.58305063
16ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)5.55981762
17response to testosterone (GO:0033574)5.43924006
18N-glycan processing (GO:0006491)5.39380735
19UDP-N-acetylglucosamine metabolic process (GO:0006047)5.33950424
20positive regulation of steroid hormone secretion (GO:2000833)5.31513446
21regulation of receptor binding (GO:1900120)5.29784544
22intestinal epithelial cell development (GO:0060576)5.26636518
23neutrophil activation involved in immune response (GO:0002283)5.14240282
24galactose catabolic process (GO:0019388)5.12166508
25fucose metabolic process (GO:0006004)4.93105122
26activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.90643720
27regulation of apoptotic process involved in morphogenesis (GO:1902337)4.88935111
28positive regulation of astrocyte differentiation (GO:0048711)4.83658773
29epithelial cell maturation (GO:0002070)4.72158907
30negative regulation of complement activation (GO:0045916)4.71193345
31protein retention in ER lumen (GO:0006621)4.69899026
32positive regulation of nuclease activity (GO:0032075)4.68125203
33calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.61574782
34angiotensin maturation (GO:0002003)4.55097088
35valine metabolic process (GO:0006573)4.44164245
36hormone catabolic process (GO:0042447)4.40912726
37positive regulation of growth hormone secretion (GO:0060124)4.38081363
38hypotonic response (GO:0006971)4.29418397
39endoplasmic reticulum unfolded protein response (GO:0030968)4.24254806
40regulation of nuclease activity (GO:0032069)4.21713677
41lung secretory cell differentiation (GO:0061140)4.13709332
42negative regulation of protein activation cascade (GO:2000258)4.13617735
43cellular response to unfolded protein (GO:0034620)4.10429186
44tight junction assembly (GO:0070830)4.08641224
45L-serine transport (GO:0015825)4.03790692
46hepatocyte apoptotic process (GO:0097284)3.98036642
47apoptotic cell clearance (GO:0043277)3.97723288
48retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.95302036
49decidualization (GO:0046697)3.92783437
50ER-nucleus signaling pathway (GO:0006984)3.90655830
51histamine secretion (GO:0001821)3.89407819
52response to endoplasmic reticulum stress (GO:0034976)3.88960953
53positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.88750895
54intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.82227220
55negative regulation of humoral immune response (GO:0002921)3.81753236
56regulation of transforming growth factor beta1 production (GO:0032908)3.81359826
57cellular response to topologically incorrect protein (GO:0035967)3.80655156
58histamine transport (GO:0051608)3.80080514
59membrane budding (GO:0006900)3.79841322
60regulation of transforming growth factor beta2 production (GO:0032909)3.78313113
61pharyngeal system development (GO:0060037)3.77088731
62nephron tubule formation (GO:0072079)3.76879647
63COPII vesicle coating (GO:0048208)3.75598579
64protein autoprocessing (GO:0016540)3.74545774
65interferon-gamma secretion (GO:0072643)3.72504957
66cell adhesion mediated by integrin (GO:0033627)3.72119123
67regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.66651905
68positive regulation of natural killer cell differentiation (GO:0032825)3.66155426
69positive regulation of odontogenesis (GO:0042482)3.61899487
70hexose catabolic process (GO:0019320)3.61406313
71activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.61400860
72pyrimidine-containing compound transmembrane transport (GO:0072531)3.56675123
73regulation of alkaline phosphatase activity (GO:0010692)3.56496559
74positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.56010882
75hemidesmosome assembly (GO:0031581)3.53965872
76positive regulation of extracellular matrix organization (GO:1903055)3.51740473
77protein N-linked glycosylation via asparagine (GO:0018279)3.51136213
78cellular extravasation (GO:0045123)3.50056736
79serine transport (GO:0032329)3.49895974
80peptidyl-asparagine modification (GO:0018196)3.48950392
81regulation of growth hormone secretion (GO:0060123)3.47892997
82regulation of steroid hormone secretion (GO:2000831)3.46712701
83vitamin transmembrane transport (GO:0035461)3.46241189
84skin morphogenesis (GO:0043589)3.43447845
85membrane raft organization (GO:0031579)3.43225547
86regulation of protein glycosylation (GO:0060049)3.40154865
87sulfur amino acid catabolic process (GO:0000098)3.38400547
88beta-amyloid metabolic process (GO:0050435)3.38286245
89cytoskeletal anchoring at plasma membrane (GO:0007016)3.34003922
90regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.33987201
91vesicle coating (GO:0006901)3.32372569
92protein heterotetramerization (GO:0051290)3.32040461
93glandular epithelial cell differentiation (GO:0002067)3.31930036
94regulation of memory T cell differentiation (GO:0043380)3.31825940
95regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.31805381
96regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.31276976
97regulation of mononuclear cell migration (GO:0071675)3.30984063
98positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.30936910
99regulation of apoptotic cell clearance (GO:2000425)3.28543716
100regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.28328093
101cytokine biosynthetic process (GO:0042089)3.25683410
102nucleotide-sugar biosynthetic process (GO:0009226)3.24232958
103positive regulation of catenin import into nucleus (GO:0035413)3.23863209
104positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.21938176
105regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.21938176
106regulation of macrophage chemotaxis (GO:0010758)3.18875821
107protein N-linked glycosylation (GO:0006487)3.18418316
108response to unfolded protein (GO:0006986)3.16776002
109regulation of natural killer cell differentiation (GO:0032823)3.16212853
110nucleotide-sugar metabolic process (GO:0009225)3.15893035
111GDP-mannose metabolic process (GO:0019673)3.14400603
112positive regulation of protein localization to plasma membrane (GO:1903078)3.14007223
113glial cell proliferation (GO:0014009)3.13476775
114regulation of transforming growth factor beta production (GO:0071634)3.11812061
115zinc ion transport (GO:0006829)3.11162081
116fucosylation (GO:0036065)3.09010055
117response to topologically incorrect protein (GO:0035966)3.08668211
118cellular modified amino acid catabolic process (GO:0042219)3.07594631
119transcytosis (GO:0045056)3.07406676
120desmosome organization (GO:0002934)3.07059601
121fibroblast migration (GO:0010761)3.05811782
122positive regulation of metanephros development (GO:0072216)3.05208118
123regulation of chemokine-mediated signaling pathway (GO:0070099)3.03720088
124regulation of water loss via skin (GO:0033561)3.03582138
125potassium ion homeostasis (GO:0055075)3.02886270
126positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.01871772
127lung vasculature development (GO:0060426)3.01771818
128peptide catabolic process (GO:0043171)3.01767007
129positive regulation of calcium ion import (GO:0090280)3.00345466
130bundle of His cell to Purkinje myocyte communication (GO:0086069)3.00006815
131ER overload response (GO:0006983)2.99073140
132chemosensory behavior (GO:0007635)2.98626480
133positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.98412603
134protein targeting to Golgi (GO:0000042)2.97336195
135positive regulation of glycoprotein metabolic process (GO:1903020)2.94628313
136pericardium development (GO:0060039)2.94004532
137galactose metabolic process (GO:0006012)2.93882609
138tyrosine phosphorylation of STAT protein (GO:0007260)2.92743864
139positive regulation of tissue remodeling (GO:0034105)2.91753983
140regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.91397208
141reverse cholesterol transport (GO:0043691)2.91047561
142positive regulation of circadian rhythm (GO:0042753)2.88690579
143monosaccharide catabolic process (GO:0046365)2.87566935
144regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.87510237
145actin filament depolymerization (GO:0030042)2.86175466
146positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.85045830
147sequestering of metal ion (GO:0051238)2.84936588
1482-oxoglutarate metabolic process (GO:0006103)2.83393329
149cell volume homeostasis (GO:0006884)2.82649787
150positive regulation of glycoprotein biosynthetic process (GO:0010560)2.82090894
151molting cycle (GO:0042303)2.81872535
152hair cycle (GO:0042633)2.81872535
153lung cell differentiation (GO:0060479)2.81481889
154phosphatidylserine metabolic process (GO:0006658)2.80703074
155negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.79900065
156mammary gland alveolus development (GO:0060749)2.79036306
157regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.78755140
158endocrine hormone secretion (GO:0060986)2.78728311
159regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.77174716
160short-chain fatty acid metabolic process (GO:0046459)2.75902919
161positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.75689931
162positive regulation of transforming growth factor beta production (GO:0071636)2.75483982
163positive regulation of neurological system process (GO:0031646)2.75026181
164positive regulation of macrophage differentiation (GO:0045651)2.72180424
165negative regulation of coagulation (GO:0050819)2.70431704
166cytokine metabolic process (GO:0042107)2.70024733
167acute inflammatory response (GO:0002526)2.68628942
168myelin assembly (GO:0032288)2.68457136
169substrate-dependent cell migration (GO:0006929)2.66555978
170regulation of metanephros development (GO:0072215)2.65297749
171regulation of intracellular pH (GO:0051453)2.63100234
172negative regulation of interleukin-1 beta production (GO:0032691)2.62546923
173lymphocyte chemotaxis (GO:0048247)2.62506304
174lens fiber cell differentiation (GO:0070306)2.62329570
175positive regulation of neutrophil migration (GO:1902624)2.60067078
176positive regulation of neutrophil chemotaxis (GO:0090023)2.60067078
177coronary vasculature morphogenesis (GO:0060977)2.56128476
178positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.55975634
179regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.54778079
180negative regulation of metanephros development (GO:0072217)2.53499735
181regulation of cellular pH (GO:0030641)2.52173131
182regulation of interleukin-8 secretion (GO:2000482)2.51975945
183Rap protein signal transduction (GO:0032486)2.51830692
184negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.51764779
185chronic inflammatory response (GO:0002544)2.51446766
186positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.50867405
187negative regulation of transcription by competitive promoter binding (GO:0010944)2.50736465
188leukocyte degranulation (GO:0043299)2.50391728
189monocyte chemotaxis (GO:0002548)2.48051043
190branching involved in prostate gland morphogenesis (GO:0060442)10.8076025

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.86535733
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.90848513
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.34120751
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.30630976
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.20641696
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.13937290
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.10560294
8ZNF263_19887448_ChIP-Seq_K562_Human3.03584215
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.89543341
10CLOCK_20551151_ChIP-Seq_293T_Human2.86639030
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.79756507
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.70499796
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.68530553
14SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.59935731
15FOXO3_23340844_ChIP-Seq_DLD1_Human2.55043359
16* SOX2_20726797_ChIP-Seq_SW620_Human2.53283170
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36613461
18CDX2_20551321_ChIP-Seq_CACO-2_Human2.36048300
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.33949510
20ZNF217_24962896_ChIP-Seq_MCF-7_Human2.30820234
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.30350998
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.30350998
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.22743438
24GATA4_25053715_ChIP-Seq_YYC3_Human2.17764142
25GATA1_22025678_ChIP-Seq_K562_Human2.17629999
26GATA6_25053715_ChIP-Seq_YYC3_Human2.14616916
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.13614628
28* AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.08974077
29EGR1_23403033_ChIP-Seq_LIVER_Mouse2.06438687
30STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04357440
31* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.98441207
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.96063148
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.94152957
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93937051
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.87194713
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.83331075
37* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.79868143
38RUNX1_27514584_Chip-Seq_MCF-7_Human1.76551607
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68808991
40AR_21909140_ChIP-Seq_LNCAP_Human1.67990543
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.67890649
42AHR_22903824_ChIP-Seq_MCF-7_Human1.67061582
43LXR_22158963_ChIP-Seq_LIVER_Mouse1.66561136
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66063193
45GATA3_24758297_ChIP-Seq_MCF-7_Human1.63063974
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.62548825
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.62343027
48* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.62314105
49JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60107713
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60028601
51ATF3_27146783_Chip-Seq_COLON_Human1.58914967
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.56190743
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56176536
54PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.53706359
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48161896
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48161896
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48161896
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47679976
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47391766
60CHD1_26751641_Chip-Seq_LNCaP_Human1.45760221
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44032336
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42355263
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.41701516
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.41639420
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39107599
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.38638693
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37985370
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35596280
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.34827666
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34198318
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34198318
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32871062
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32740962
74FOXA1_25552417_ChIP-Seq_VCAP_Human1.32137651
75RACK7_27058665_Chip-Seq_MCF-7_Human1.32128151
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.31589027
77ELF5_23300383_ChIP-Seq_T47D_Human1.30398387
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29569579
79CJUN_26792858_Chip-Seq_BT549_Human1.29061942
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28849703
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.27672383
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.26866911
83CREB1_26743006_Chip-Seq_LNCaP_Human1.23539299
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23526637
85VDR_24787735_ChIP-Seq_THP-1_Human1.22825167
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21825041
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21093815
88EGR1_19374776_ChIP-ChIP_THP-1_Human1.17716576
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17432232
90ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17195724
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.15020326
92PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11239696
93KLF5_25053715_ChIP-Seq_YYC3_Human1.08397825
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.08229241
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07896690
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07697504
97CDX2_22108803_ChIP-Seq_LS180_Human1.07639347
98TP53_22127205_ChIP-Seq_IMR90_Human1.07436428
99SMAD3_21741376_ChIP-Seq_HESCs_Human1.07098991
100TP53_16413492_ChIP-PET_HCT116_Human1.04060893
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03654343
102STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02494901
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02247602
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01334586
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00252311
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99627947
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98176994
108GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.97106053
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95789018
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95679263
111NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95095125
112* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94499268
113P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93893363
114BRD4_25478319_ChIP-Seq_HGPS_Human0.90504379
115P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89820810
116FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88977639
117TP53_18474530_ChIP-ChIP_U2OS_Human0.88798183
118STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88407550
119SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86009541
120IRF8_21731497_ChIP-ChIP_J774_Mouse0.85796377
121TP63_23658742_ChIP-Seq_EP156T_Human0.85731384
122FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85680500
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84907983
124ELK1_22589737_ChIP-Seq_MCF10A_Human0.84846850
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83541052
126HNF4A_19822575_ChIP-Seq_HepG2_Human0.82482355
127MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82415626
128ZNF274_21170338_ChIP-Seq_K562_Hela0.82089328
129FOXA1_21572438_ChIP-Seq_LNCaP_Human0.79561727
130SMAD3_21741376_ChIP-Seq_EPCs_Human0.78832934
131* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76063374
132PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.72845748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.37825879
2MP0005310_abnormal_salivary_gland4.91039497
3MP0002138_abnormal_hepatobiliary_system4.85488118
4MP0002166_altered_tumor_susceptibility4.56138946
5MP0000537_abnormal_urethra_morphology4.48956967
6MP0009840_abnormal_foam_cell4.32794213
7MP0003950_abnormal_plasma_membrane3.59834006
8MP0002006_tumorigenesis3.48458197
9MP0005647_abnormal_sex_gland3.20783594
10MP0010386_abnormal_urinary_bladder3.13218550
11MP0004264_abnormal_extraembryonic_tissu2.90985779
12MP0003191_abnormal_cellular_cholesterol2.87842440
13MP0004043_abnormal_pH_regulation2.80944443
14MP0002163_abnormal_gland_morphology2.76100568
15MP0000613_abnormal_salivary_gland2.60925663
16MP0002139_abnormal_hepatobiliary_system2.58659875
17MP0001873_stomach_inflammation2.41233134
18MP0010352_gastrointestinal_tract_polyps2.37686200
19* MP0005023_abnormal_wound_healing2.18049484
20MP0005084_abnormal_gallbladder_morpholo2.17877133
21MP0006054_spinal_hemorrhage2.14563786
22MP0001765_abnormal_ion_homeostasis2.11767118
23MP0003724_increased_susceptibility_to2.04903905
24MP0009785_altered_susceptibility_to2.04098402
25MP0010678_abnormal_skin_adnexa2.02184948
26MP0002148_abnormal_hypersensitivity_rea1.97515752
27MP0000538_abnormal_urinary_bladder1.96643163
28MP0001756_abnormal_urination1.95966483
29MP0003183_abnormal_peptide_metabolism1.95411465
30MP0009780_abnormal_chondrocyte_physiolo1.91812341
31MP0001984_abnormal_olfaction1.84066068
32MP0001666_abnormal_nutrient_absorption1.76021259
33MP0002277_abnormal_respiratory_mucosa1.71250238
34MP0003656_abnormal_erythrocyte_physiolo1.68202856
35MP0003195_calcinosis1.68025037
36MP0002295_abnormal_pulmonary_circulatio1.67367491
37MP0005220_abnormal_exocrine_pancreas1.60825262
38MP0005379_endocrine/exocrine_gland_phen1.57484002
39MP0000685_abnormal_immune_system1.57450610
40MP0002928_abnormal_bile_duct1.57246441
41MP0000462_abnormal_digestive_system1.56005089
42MP0002009_preneoplasia1.53675717
43MP0004233_abnormal_muscle_weight1.52391184
44MP0008004_abnormal_stomach_pH1.51909928
45MP0009643_abnormal_urine_homeostasis1.50112914
46MP0003705_abnormal_hypodermis_morpholog1.49703491
47MP0005636_abnormal_mineral_homeostasis1.48755965
48MP0002132_abnormal_respiratory_system1.44757005
49MP0003011_delayed_dark_adaptation1.34518683
50MP0009384_cardiac_valve_regurgitation1.33000225
51MP0005058_abnormal_lysosome_morphology1.32679083
52MP0003566_abnormal_cell_adhesion1.32359244
53MP0000858_altered_metastatic_potential1.31271344
54MP0000604_amyloidosis1.28970216
55* MP0010155_abnormal_intestine_physiology1.24921684
56MP0003436_decreased_susceptibility_to1.23829864
57MP0002136_abnormal_kidney_physiology1.20993182
58* MP0002419_abnormal_innate_immunity1.20558094
59MP0000627_abnormal_mammary_gland1.20327631
60MP0002796_impaired_skin_barrier1.18207502
61MP0003045_fibrosis1.17304559
62MP0005332_abnormal_amino_acid1.16740081
63* MP0001845_abnormal_inflammatory_respons1.14175646
64MP0000490_abnormal_crypts_of1.13295411
65MP0003329_amyloid_beta_deposits1.10953881
66MP0004272_abnormal_basement_membrane1.10334228
67MP0005381_digestive/alimentary_phenotyp1.10145791
68MP0008872_abnormal_physiological_respon1.09468568
69MP0001790_abnormal_immune_system1.09116076
70MP0005387_immune_system_phenotype1.09116076
71MP0002909_abnormal_adrenal_gland1.08770893
72* MP0005025_abnormal_response_to1.07646967
73MP0003453_abnormal_keratinocyte_physiol1.06774668
74MP0001663_abnormal_digestive_system1.05671867
75MP0001533_abnormal_skeleton_physiology1.04619769
76MP0008875_abnormal_xenobiotic_pharmacok1.04100349
77MP0001853_heart_inflammation1.03690781
78MP0001664_abnormal_digestion1.02607776
79MP0000534_abnormal_ureter_morphology1.00340727
80MP0005275_abnormal_skin_tensile1.00140815
81MP0008438_abnormal_cutaneous_collagen0.99738553
82* MP0000477_abnormal_intestine_morphology0.98630512
83MP0001545_abnormal_hematopoietic_system0.97126741
84MP0005397_hematopoietic_system_phenotyp0.97126741
85MP0003252_abnormal_bile_duct0.95431002
86MP0001299_abnormal_eye_distance/0.93884894
87MP0005167_abnormal_blood-brain_barrier0.92621453
88MP0004883_abnormal_blood_vessel0.92187509
89MP0002098_abnormal_vibrissa_morphology0.92182645
90* MP0002452_abnormal_antigen_presenting0.91978945
91MP0005085_abnormal_gallbladder_physiolo0.90438660
92MP0002060_abnormal_skin_morphology0.89106892
93MP0000566_synostosis0.89004796
94MP0001270_distended_abdomen0.87764568
95MP0004019_abnormal_vitamin_homeostasis0.87642056
96MP0002876_abnormal_thyroid_physiology0.87538805
97* MP0000343_altered_response_to0.86183432
98MP0005187_abnormal_penis_morphology0.84240753
99MP0001216_abnormal_epidermal_layer0.83876206
100MP0002896_abnormal_bone_mineralization0.83073361
101MP0002135_abnormal_kidney_morphology0.82418819
102MP0001485_abnormal_pinna_reflex0.82364384
103MP0005076_abnormal_cell_differentiation0.81544831
104MP0003638_abnormal_response/metabolism_0.81491948
105MP0005367_renal/urinary_system_phenotyp0.79870418
106MP0000516_abnormal_urinary_system0.79870418
107MP0000249_abnormal_blood_vessel0.78761197
108* MP0003866_abnormal_defecation0.78674658
109MP0005319_abnormal_enzyme/_coenzyme0.77441207
110* MP0009764_decreased_sensitivity_to0.77422254
111MP0001944_abnormal_pancreas_morphology0.77322639
112MP0003315_abnormal_perineum_morphology0.76481955
113MP0002089_abnormal_postnatal_growth/wei0.74871737
114MP0000470_abnormal_stomach_morphology0.74680537
115MP0001881_abnormal_mammary_gland0.74664063
116MP0004782_abnormal_surfactant_physiolog0.74562654
117MP0008469_abnormal_protein_level0.74359263
118MP0001346_abnormal_lacrimal_gland0.73902862
119MP0005670_abnormal_white_adipose0.73817550
120* MP0003300_gastrointestinal_ulcer0.73440018
121MP0002933_joint_inflammation0.73188099
122MP0002168_other_aberrant_phenotype0.71409394
123MP0004947_skin_inflammation0.71150619
124MP0003936_abnormal_reproductive_system0.71134649
125MP0003186_abnormal_redox_activity0.69544267
126MP0005501_abnormal_skin_physiology0.69502196
127MP0001849_ear_inflammation0.69236468
128MP0005000_abnormal_immune_tolerance0.69083882
129MP0005164_abnormal_response_to0.68721146
130MP0003279_aneurysm0.68583546
131MP0005248_abnormal_Harderian_gland0.68507290
132MP0002254_reproductive_system_inflammat0.67874658
133MP0000230_abnormal_systemic_arterial0.67690828
134MP0004134_abnormal_chest_morphology0.67118263
135MP0002111_abnormal_tail_morphology0.67004611
136MP0005083_abnormal_biliary_tract0.66218461
137MP0003091_abnormal_cell_migration0.65278773
138MP0003890_abnormal_embryonic-extraembry0.64241308
139* MP0009765_abnormal_xenobiotic_induced0.64105105
140MP0005410_abnormal_fertilization0.63550076
141MP0000609_abnormal_liver_physiology0.63182900
142MP0003868_abnormal_feces_composition0.63003568
143MP0000377_abnormal_hair_follicle0.62371394
144MP0005408_hypopigmentation0.62136389
145MP0005365_abnormal_bile_salt0.60641010
146* MP0005166_decreased_susceptibility_to0.60069184
147MP0003075_altered_response_to0.59861468
148MP0000465_gastrointestinal_hemorrhage0.57362027
149MP0000762_abnormal_tongue_morphology0.56789164
150MP0005165_increased_susceptibility_to0.56120415

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cochlea (HP:0000375)6.15326909
2Ileus (HP:0002595)5.81235208
3Aortic aneurysm (HP:0004942)4.58596883
4Right ventricular cardiomyopathy (HP:0011663)4.28959123
5Abnormality of chloride homeostasis (HP:0011422)4.17992663
6Morphological abnormality of the inner ear (HP:0011390)4.05905778
7Micronodular cirrhosis (HP:0001413)3.96009010
8Abnormality of the right ventricle (HP:0001707)3.95928774
9Vacuolated lymphocytes (HP:0001922)3.79444175
10Hydroxyprolinuria (HP:0003080)3.78354240
11Abnormality of proline metabolism (HP:0010907)3.78354240
12Steatorrhea (HP:0002570)3.68960002
13Intrahepatic cholestasis (HP:0001406)3.62317331
14Abnormality of glycolipid metabolism (HP:0010969)3.60356411
15Abnormality of liposaccharide metabolism (HP:0010968)3.60356411
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.60356411
17Malnutrition (HP:0004395)3.58561911
18Spondylolisthesis (HP:0003302)3.57733468
19Woolly hair (HP:0002224)3.56286307
20Azoospermia (HP:0000027)3.52042435
21Erythema (HP:0010783)3.49070138
22Onycholysis (HP:0001806)3.41154185
23Facial shape deformation (HP:0011334)3.39183900
24Potter facies (HP:0002009)3.39183900
25Rectal prolapse (HP:0002035)3.36039123
26Abnormality of the intrinsic pathway (HP:0010989)3.35042815
27Abnormal pancreas size (HP:0012094)3.32655358
28Increased CSF protein (HP:0002922)3.31944773
29Cone-rod dystrophy (HP:0000548)3.30450379
30Irregular vertebral endplates (HP:0003301)3.26447515
31Vascular tortuosity (HP:0004948)3.22635774
32Aortic dissection (HP:0002647)3.19607401
33Hypotrichosis (HP:0001006)3.15865508
34Fat malabsorption (HP:0002630)3.15616306
35Tetraparesis (HP:0002273)3.14219479
36Sparse eyelashes (HP:0000653)3.11066382
37Hypoplasia of the uterus (HP:0000013)3.07678055
38Pili torti (HP:0003777)3.07539563
39Subcapsular cataract (HP:0000523)3.06657062
40Late onset (HP:0003584)3.03891007
41Gout (HP:0001997)3.03002997
42Biliary tract neoplasm (HP:0100574)2.82198502
43Mitral stenosis (HP:0001718)2.79644845
44Abdominal distention (HP:0003270)2.79019935
45Subacute progressive viral hepatitis (HP:0006572)2.75411066
46Scotoma (HP:0000575)2.73684329
47Neonatal death (HP:0003811)2.72906769
48Abnormal biliary tract morphology (HP:0012440)2.70179051
49Abnormal foot bone ossification (HP:0010675)2.69350598
50Abnormality of the 2nd finger (HP:0004100)2.68349030
51Palpitations (HP:0001962)2.67902591
52Achilles tendon contracture (HP:0001771)2.67278171
53Petechiae (HP:0000967)2.65455495
54Portal hypertension (HP:0001409)2.59179385
55Stenosis of the external auditory canal (HP:0000402)2.58966219
56Congenital, generalized hypertrichosis (HP:0004540)2.57994592
57Parakeratosis (HP:0001036)2.57186668
58Urinary glycosaminoglycan excretion (HP:0003541)2.56840033
59Mucopolysacchariduria (HP:0008155)2.56840033
60Exocrine pancreatic insufficiency (HP:0001738)2.56034463
61Dysostosis multiplex (HP:0000943)2.54635234
62Hypothermia (HP:0002045)2.54272229
63Milia (HP:0001056)2.53059166
64Tubulointerstitial fibrosis (HP:0005576)2.51076155
65Hypoplasia of the pons (HP:0012110)2.50867476
66Systemic lupus erythematosus (HP:0002725)2.50790384
67Aneurysm (HP:0002617)2.50333015
68Abnormality of monocarboxylic acid metabolism (HP:0010996)2.49977577
69Hyperglycinuria (HP:0003108)2.49080798
70Ventricular tachycardia (HP:0004756)2.47834320
71Abnormality of the Achilles tendon (HP:0005109)2.47543140
72Radial bowing (HP:0002986)2.47044621
73Abnormality of glutamine family amino acid metabolism (HP:0010902)2.46282441
74Atrophic scars (HP:0001075)2.45934117
75Abnormality of the axillary hair (HP:0100134)2.45760638
76Abnormality of secondary sexual hair (HP:0009888)2.45760638
77Sensorimotor neuropathy (HP:0007141)2.45259254
78Unilateral renal agenesis (HP:0000122)2.43145725
79Severe visual impairment (HP:0001141)2.42203190
80Fibular aplasia (HP:0002990)2.41178870
81Abnormality of the vertebral endplates (HP:0005106)2.40279862
82Increased purine levels (HP:0004368)2.40258823
83Hyperuricemia (HP:0002149)2.40258823
84Pustule (HP:0200039)2.38474031
85Recurrent pneumonia (HP:0006532)2.38196057
86Hypoplasia of dental enamel (HP:0006297)2.37814029
87Abnormality of the hepatic vasculature (HP:0006707)2.35066403
88Curly hair (HP:0002212)2.35034951
89Aplasia of the phalanges of the hand (HP:0009802)2.33809391
90Aplasia involving bones of the extremities (HP:0009825)2.33809391
91Aplasia involving bones of the upper limbs (HP:0009823)2.33809391
92Dehydration (HP:0001944)2.33030877
93Male infertility (HP:0003251)2.32558293
94Focal segmental glomerulosclerosis (HP:0000097)2.30383267
95Central scotoma (HP:0000603)2.29286303
96Hand muscle atrophy (HP:0009130)2.28712382
97Widely patent fontanelles and sutures (HP:0004492)2.27419809
98Hypoplastic nipples (HP:0002557)2.25757569
99Abnormal hair laboratory examination (HP:0003328)2.24823579
100Thoracolumbar scoliosis (HP:0002944)2.24135989
101Abnormality of polysaccharide metabolism (HP:0011012)2.22322362
102Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22322362
103Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22322362
104Slow-growing hair (HP:0002217)2.21352442
105Abnormality of hair growth rate (HP:0011363)2.21352442
106Abnormality of macrophages (HP:0004311)2.19628095
107Esophageal varix (HP:0002040)2.19166009
108Ureteral stenosis (HP:0000071)2.15684630
109Back pain (HP:0003418)2.15386481
110Abnormal spermatogenesis (HP:0008669)2.14993232
111Abnormality of the pons (HP:0007361)2.14088579
112Short hallux (HP:0010109)2.13415913
113Microretrognathia (HP:0000308)2.13005026
114Ureteral obstruction (HP:0006000)2.11763751
115Hematochezia (HP:0002573)2.10798568
116Polar cataract (HP:0010696)2.10674294
117Ulnar bowing (HP:0003031)2.10498276
118Glomerulonephritis (HP:0000099)2.10110933
119Aplasia/hypoplasia of the uterus (HP:0008684)2.08828867
120Coxa valga (HP:0002673)2.08242718
121Generalized aminoaciduria (HP:0002909)2.08193572
122Thrombocytosis (HP:0001894)2.06650719
123Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.06008522
124Abnormality of oral frenula (HP:0000190)2.04562561
125Arterial tortuosity (HP:0005116)2.03615913
126Spastic diplegia (HP:0001264)2.02937916
127Abnormal tarsal ossification (HP:0008369)2.01584808
128Gastrointestinal carcinoma (HP:0002672)2.00423893
129Malignant gastrointestinal tract tumors (HP:0006749)2.00423893
130Alopecia of scalp (HP:0002293)2.00363201
131Nail dystrophy (HP:0008404)1.99827862
132Glomerulosclerosis (HP:0000096)1.99052288
133Interstitial pulmonary disease (HP:0006530)1.98590279
134Abnormality of macular pigmentation (HP:0008002)1.97845777
135Barrel-shaped chest (HP:0001552)1.96773333
136Tongue fasciculations (HP:0001308)1.96541582
137Plantar hyperkeratosis (HP:0007556)1.95965543
138Shawl scrotum (HP:0000049)1.95690285
139Aplasia/Hypoplasia of the hallux (HP:0008362)1.95523821
140Tubulointerstitial abnormality (HP:0001969)1.95489862
141Osteomyelitis (HP:0002754)1.94254461
142Bowing of the arm (HP:0006488)1.92722167
143Bowed forearm bones (HP:0003956)1.92722167
144Hypoplastic labia majora (HP:0000059)1.92512118
145Abnormality of transition element cation homeostasis (HP:0011030)1.92473903
146Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.92052634
147Ankyloglossia (HP:0010296)1.91748506
148Beaking of vertebral bodies (HP:0004568)1.90417411
149Eczematoid dermatitis (HP:0000976)1.89966088
150Growth hormone excess (HP:0000845)1.88683746
151Distal upper limb amyotrophy (HP:0007149)1.88364862
152Upper limb amyotrophy (HP:0009129)1.88364862
153Aortic regurgitation (HP:0001659)1.87859172
154Pulmonary fibrosis (HP:0002206)1.87798909
155Facial diplegia (HP:0001349)1.87753803
156Glucose intolerance (HP:0000833)1.87458945
157Abnormality of serine family amino acid metabolism (HP:0010894)1.86364719
158Abnormality of glycine metabolism (HP:0010895)1.86364719
159Aplastic anemia (HP:0001915)1.86244188
160Hyperphosphatemia (HP:0002905)1.86110141
161Fragile nails (HP:0001808)1.85720505
162Abnormality of the gastric mucosa (HP:0004295)1.85303982
163Short humerus (HP:0005792)1.84332796
164Abnormal blistering of the skin (HP:0008066)1.83895332
165Vascular calcification (HP:0004934)1.82930940
166Metaphyseal irregularity (HP:0003025)1.82572926
167Cerebral palsy (HP:0100021)1.82000049
168Recurrent gram-negative bacterial infections (HP:0005420)1.81445218
169Xanthomatosis (HP:0000991)1.79360756
170Abnormality of the intervertebral disk (HP:0005108)1.78082946

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.82168327
2MST45.64604727
3EPHA25.47686111
4AKT34.78407807
5ERN13.70032618
6STK393.37466212
7SIK33.11339457
8STK243.00719469
9TAOK32.92550896
10LATS12.89823025
11EEF2K2.62712258
12TRIM282.37692304
13SCYL22.25608268
14MAP3K22.17528140
15LMTK22.16713192
16MYLK2.10472799
17RPS6KB22.02800400
18BCKDK1.95787907
19TTN1.94722519
20PRKG21.93216646
21OXSR11.85537149
22CDK81.72961160
23FER1.71442062
24LRRK21.63115036
25PTK61.59260039
26SIK11.53536698
27NUAK11.43368190
28BCR1.41513914
29MST1R1.39560085
30MAPKAPK31.37265098
31STK101.34238116
32STK381.33149127
33MAP2K21.28973031
34ZAK1.21099057
35PDK21.20517079
36TESK11.20088090
37ILK1.17799436
38TRIB31.01576388
39ERBB40.94769913
40MAP3K90.91488721
41PTK20.88355703
42DAPK10.83554168
43MET0.83313542
44PRKCI0.82747568
45MAP3K30.82700511
46IKBKB0.82231097
47IRAK30.81881419
48RIPK10.81223756
49PIK3CA0.78038188
50TESK20.76649137
51PDGFRA0.74152127
52PAK40.73928094
53JAK30.71575480
54CDC42BPA0.65804396
55DMPK0.64934511
56CDK90.63444711
57PKN20.63372120
58ROCK20.60176004
59PIK3CG0.60090106
60STK30.59460323
61KSR20.57877616
62MAP3K80.55470341
63NTRK10.54666662
64PAK20.52962820
65MAP3K120.51910295
66MAP2K10.50406827
67EPHB10.49857094
68PAK30.49516218
69NLK0.49378655
70DDR20.48589063
71TNK20.47514108
72FGFR20.47110840
73ROCK10.47091527
74TRPM70.46952300
75NME10.46346471
76EPHA30.45815663
77DAPK30.45799580
78JAK20.45798767
79MAP3K140.45066528
80RPS6KA20.44416817
81MELK0.40962098
82HIPK20.40456414
83LIMK10.39107275
84EIF2AK30.38944142
85EPHB20.38806205
86MKNK20.37276663
87KSR10.36047783
88CAMK2G0.35229026
89MARK20.34624012
90JAK10.33276539
91TGFBR20.33231796
92ERBB30.32173728
93CAMK2B0.31427468
94MAP3K70.31005572
95MATK0.30822001
96NEK60.30284394
97TYK20.29845025
98CAMK2D0.28675578
99MINK10.27798937
100ERBB20.27747798
101BMPR1B0.26971979
102CHUK0.25870027
103BRSK20.25125936
104MAP3K10.24185757
105EGFR0.23939323
106CSK0.23849381
107NEK90.23701130
108PRKCQ0.23611066
109TNIK0.23583611
110CSF1R0.23145432
111NME20.22310126
112IKBKE0.22094909
113FYN0.21977544
114DAPK20.21544467
115MTOR0.21155914
116INSRR0.20618758
117TGFBR10.20364139
118GSK3A0.20021305
119PDK30.19611043
120PDK40.19611043
121GRK10.19096668
122CSNK1A1L0.18592103
123CASK0.17242774
124SRC0.17223766
125PIM20.16833246
126ABL10.16732967
127INSR0.16545374
128TBK10.16540811
129PDPK10.16152561
130PDK10.15563771
131BMX0.15065088
132PDGFRB0.15010064
133AKT20.14596479
134PRKCE0.13982266
135LATS20.12620627
136RET0.12032273
137RPS6KL10.11709317
138RPS6KC10.11709317
139CSNK1G30.10957369
140CDK60.10931179
141CSNK1A10.10830250
142STK38L0.10421210
143PRKCZ0.10279159
144FGFR10.10231686
145PRKCG0.08992768
146ADRBK20.08681948
147ICK0.08551891
148IGF1R0.08187769

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.26688534
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.20794271
3Sulfur metabolism_Homo sapiens_hsa009203.79158047
4Steroid biosynthesis_Homo sapiens_hsa001003.03418287
5Protein export_Homo sapiens_hsa030602.84199871
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.56796055
7N-Glycan biosynthesis_Homo sapiens_hsa005102.51613433
8Vibrio cholerae infection_Homo sapiens_hsa051102.41315436
9Renin-angiotensin system_Homo sapiens_hsa046142.33667630
10Tight junction_Homo sapiens_hsa045302.11398105
11Butanoate metabolism_Homo sapiens_hsa006502.02027001
12Small cell lung cancer_Homo sapiens_hsa052221.78463946
13Bladder cancer_Homo sapiens_hsa052191.76121215
14ECM-receptor interaction_Homo sapiens_hsa045121.72849285
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.71499664
16Other glycan degradation_Homo sapiens_hsa005111.64350878
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.64171327
18Complement and coagulation cascades_Homo sapiens_hsa046101.61846321
19Adherens junction_Homo sapiens_hsa045201.61311646
20Prostate cancer_Homo sapiens_hsa052151.60399787
21Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.46660985
22Focal adhesion_Homo sapiens_hsa045101.45579589
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45389777
24Endometrial cancer_Homo sapiens_hsa052131.45151546
25Pertussis_Homo sapiens_hsa051331.37867976
26Amoebiasis_Homo sapiens_hsa051461.35630803
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.35024593
28Thyroid hormone synthesis_Homo sapiens_hsa049181.31809933
29Fructose and mannose metabolism_Homo sapiens_hsa000511.31579938
30Hepatitis C_Homo sapiens_hsa051601.30994381
31Arginine biosynthesis_Homo sapiens_hsa002201.30795059
32Vitamin B6 metabolism_Homo sapiens_hsa007501.23276907
33Malaria_Homo sapiens_hsa051441.20352638
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19501517
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17875469
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17692499
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.17438956
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14069339
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13939330
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12830023
41Legionellosis_Homo sapiens_hsa051341.12814638
42Circadian rhythm_Homo sapiens_hsa047101.10278292
43Tuberculosis_Homo sapiens_hsa051521.07358184
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07026489
45Shigellosis_Homo sapiens_hsa051311.05631441
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05024976
47Protein digestion and absorption_Homo sapiens_hsa049741.04749170
48Hippo signaling pathway_Homo sapiens_hsa043901.04234020
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03418299
50Proteoglycans in cancer_Homo sapiens_hsa052051.03288425
51Thyroid cancer_Homo sapiens_hsa052161.01373930
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99875212
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99651975
54Phagosome_Homo sapiens_hsa041450.98925805
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.97421459
56Galactose metabolism_Homo sapiens_hsa000520.91573201
57Fatty acid degradation_Homo sapiens_hsa000710.90184002
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88327137
59Chemical carcinogenesis_Homo sapiens_hsa052040.87963361
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87559081
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86084572
62Glutathione metabolism_Homo sapiens_hsa004800.85502385
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85474417
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.85453628
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82513078
66Propanoate metabolism_Homo sapiens_hsa006400.81100077
67Pancreatic cancer_Homo sapiens_hsa052120.80722399
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.80609308
69Chronic myeloid leukemia_Homo sapiens_hsa052200.80578590
70ErbB signaling pathway_Homo sapiens_hsa040120.80326317
71Leishmaniasis_Homo sapiens_hsa051400.79192188
72Staphylococcus aureus infection_Homo sapiens_hsa051500.79154918
73Dorso-ventral axis formation_Homo sapiens_hsa043200.77345824
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.76724664
75Osteoclast differentiation_Homo sapiens_hsa043800.75436143
76Inositol phosphate metabolism_Homo sapiens_hsa005620.74936722
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74730834
78Starch and sucrose metabolism_Homo sapiens_hsa005000.74315081
79Nitrogen metabolism_Homo sapiens_hsa009100.74304951
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.73956683
81African trypanosomiasis_Homo sapiens_hsa051430.73945282
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.72827223
83Histidine metabolism_Homo sapiens_hsa003400.72547761
84Lysosome_Homo sapiens_hsa041420.71300397
85ABC transporters_Homo sapiens_hsa020100.70646504
86Collecting duct acid secretion_Homo sapiens_hsa049660.70559248
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70294215
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67399895
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66071700
90Toxoplasmosis_Homo sapiens_hsa051450.64968705
91TGF-beta signaling pathway_Homo sapiens_hsa043500.64841051
92Pathways in cancer_Homo sapiens_hsa052000.63768515
93Melanoma_Homo sapiens_hsa052180.63698024
94Arginine and proline metabolism_Homo sapiens_hsa003300.61248156
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61211698
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60996275
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60666983
98Mineral absorption_Homo sapiens_hsa049780.60412852
99mTOR signaling pathway_Homo sapiens_hsa041500.60319802
100Retinol metabolism_Homo sapiens_hsa008300.59895001
101Sulfur relay system_Homo sapiens_hsa041220.59342765
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58846423
103Fat digestion and absorption_Homo sapiens_hsa049750.58778277
104Glioma_Homo sapiens_hsa052140.57498902
105Non-small cell lung cancer_Homo sapiens_hsa052230.57386649
106Insulin resistance_Homo sapiens_hsa049310.55824605
107Chemokine signaling pathway_Homo sapiens_hsa040620.55774902
108Bile secretion_Homo sapiens_hsa049760.54793891
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54206913
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51782176
111TNF signaling pathway_Homo sapiens_hsa046680.51499545
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49647703
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49490008
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48980072
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48716792
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47878467
117Estrogen signaling pathway_Homo sapiens_hsa049150.47177827
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44645131
119B cell receptor signaling pathway_Homo sapiens_hsa046620.43813290
120Rheumatoid arthritis_Homo sapiens_hsa053230.43017668
121Endocytosis_Homo sapiens_hsa041440.42968599
122Vitamin digestion and absorption_Homo sapiens_hsa049770.41895445
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.41571209
124Salmonella infection_Homo sapiens_hsa051320.40727090
125Ether lipid metabolism_Homo sapiens_hsa005650.40563925
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39206512
127Influenza A_Homo sapiens_hsa051640.39079039
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38953471
129AMPK signaling pathway_Homo sapiens_hsa041520.38085527
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37724189
131Sphingolipid metabolism_Homo sapiens_hsa006000.37006511
132Choline metabolism in cancer_Homo sapiens_hsa052310.36658231
133Renal cell carcinoma_Homo sapiens_hsa052110.36395643
134Hematopoietic cell lineage_Homo sapiens_hsa046400.36334372
135Gap junction_Homo sapiens_hsa045400.35558565
136Pancreatic secretion_Homo sapiens_hsa049720.35209104
137Pyruvate metabolism_Homo sapiens_hsa006200.33435782
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.32970690
139Antigen processing and presentation_Homo sapiens_hsa046120.32892818
140Prolactin signaling pathway_Homo sapiens_hsa049170.32431434
141FoxO signaling pathway_Homo sapiens_hsa040680.32163437
142Gastric acid secretion_Homo sapiens_hsa049710.31599103
143PPAR signaling pathway_Homo sapiens_hsa033200.31523504
144Prion diseases_Homo sapiens_hsa050200.31458483
145HIF-1 signaling pathway_Homo sapiens_hsa040660.29749168
146Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29184397
147Platelet activation_Homo sapiens_hsa046110.29007975
148Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28313053

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