MMP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular extravasation (GO:0045123)8.46164880
2leukocyte aggregation (GO:0070486)8.30154412
3leukocyte migration involved in inflammatory response (GO:0002523)7.31532074
4neutrophil mediated immunity (GO:0002446)7.19570412
5defense response to fungus (GO:0050832)7.00910894
6neutrophil activation involved in immune response (GO:0002283)6.84770489
7positive regulation of mast cell activation (GO:0033005)6.23784561
8response to peptidoglycan (GO:0032494)6.23426702
9neutrophil activation (GO:0042119)6.12096940
10regulation of B cell receptor signaling pathway (GO:0050855)5.82890576
11neutrophil chemotaxis (GO:0030593)5.81287190
12respiratory burst (GO:0045730)5.76335201
13neutrophil migration (GO:1990266)5.65913070
14negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.61891689
15production of molecular mediator involved in inflammatory response (GO:0002532)5.61530128
16granulocyte activation (GO:0036230)5.59797115
17disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.56870860
18killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.56870860
19detection of other organism (GO:0098543)5.55622918
20detection of bacterium (GO:0016045)5.53912136
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.53415779
22response to host immune response (GO:0052572)5.53415779
23myeloid leukocyte mediated immunity (GO:0002444)5.49990875
24response to fungus (GO:0009620)5.43298201
25response to defenses of other organism involved in symbiotic interaction (GO:0052173)5.18689794
26response to host (GO:0075136)5.18689794
27response to host defenses (GO:0052200)5.18689794
28regulation of mononuclear cell migration (GO:0071675)5.16354683
29granulocyte chemotaxis (GO:0071621)4.90484621
30regulation of mast cell activation (GO:0033003)4.88714487
31granulocyte migration (GO:0097530)4.87877978
32regulation of vitamin D biosynthetic process (GO:0060556)4.75324500
33glycosphingolipid catabolic process (GO:0046479)4.74512264
34regulation of myeloid leukocyte mediated immunity (GO:0002886)4.73511292
35negative regulation of cell killing (GO:0031342)4.65394215
36negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.65394215
37diterpenoid biosynthetic process (GO:0016102)4.63685250
38sequestering of metal ion (GO:0051238)4.61268117
39regulation of leukocyte degranulation (GO:0043300)4.56966761
40oligosaccharide catabolic process (GO:0009313)4.47156756
41cellular response to thyroid hormone stimulus (GO:0097067)4.44017684
42lipopolysaccharide-mediated signaling pathway (GO:0031663)4.31965172
43glycolipid catabolic process (GO:0019377)4.25723240
44positive regulation of mast cell activation involved in immune response (GO:0033008)4.24006332
45positive regulation of mast cell degranulation (GO:0043306)4.24006332
46regulation of mast cell degranulation (GO:0043304)4.23585906
47negative regulation of phagocytosis (GO:0050765)4.22831797
48positive regulation by symbiont of host defense response (GO:0052509)4.21291674
49modulation by symbiont of host defense response (GO:0052031)4.21291674
50modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.21291674
51modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.21291674
52positive regulation by organism of defense response of other organism involved in symbiotic interact4.21291674
53modulation by symbiont of host immune response (GO:0052553)4.21291674
54progesterone metabolic process (GO:0042448)4.20538265
55regulation of regulated secretory pathway (GO:1903305)4.19601632
56killing of cells of other organism (GO:0031640)4.11703995
57disruption of cells of other organism (GO:0044364)4.11703995
58amino sugar catabolic process (GO:0046348)4.04426112
59positive regulation of toll-like receptor signaling pathway (GO:0034123)4.04344059
60monocyte chemotaxis (GO:0002548)4.01644617
61regulation of podosome assembly (GO:0071801)4.00739059
62regulation of mast cell activation involved in immune response (GO:0033006)3.99160556
63positive regulation of chemokine biosynthetic process (GO:0045080)3.93838868
64Arp2/3 complex-mediated actin nucleation (GO:0034314)3.93430855
65pentose-phosphate shunt (GO:0006098)3.88598582
66cellular response to zinc ion (GO:0071294)3.83379642
67negative regulation of myeloid cell apoptotic process (GO:0033033)3.82227027
68ceramide catabolic process (GO:0046514)3.79121164
69positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.77644608
70positive regulation of heat generation (GO:0031652)3.76807386
71phagosome maturation (GO:0090382)3.75435208
72positive regulation of osteoblast proliferation (GO:0033690)3.73939289
73negative regulation of mast cell activation (GO:0033004)3.72584162
74regulation of vitamin metabolic process (GO:0030656)3.71548825
75regulation of macrophage chemotaxis (GO:0010758)3.67636007
76regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.65126508
77NIK/NF-kappaB signaling (GO:0038061)3.64653248
78negative regulation of nitric oxide biosynthetic process (GO:0045019)3.64289669
79regulation of cytokine secretion involved in immune response (GO:0002739)3.62478041
80positive regulation of lamellipodium assembly (GO:0010592)3.62173800
81myeloid dendritic cell differentiation (GO:0043011)3.60585617
82leukocyte cell-cell adhesion (GO:0007159)3.52973166
83negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.52922320
84regulation of fever generation (GO:0031620)3.52823092
85immunoglobulin mediated immune response (GO:0016064)3.51474940
86positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.51283544
87myeloid leukocyte migration (GO:0097529)3.50920813
88eosinophil chemotaxis (GO:0048245)3.49067503
89positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.48507753
90membrane lipid catabolic process (GO:0046466)3.47901350
91negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.47765360
92NADPH regeneration (GO:0006740)3.46822243
93positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.46716443
94hydrogen peroxide biosynthetic process (GO:0050665)3.46209415
95dendritic cell migration (GO:0036336)3.45223940
96dendritic cell chemotaxis (GO:0002407)3.44835360
97adaptation of signaling pathway (GO:0023058)3.44287621
98response to thyroid hormone (GO:0097066)3.44244877
99superoxide anion generation (GO:0042554)3.43392290
100T-helper 1 type immune response (GO:0042088)3.41191286
101regulation of chemokine biosynthetic process (GO:0045073)3.39767272
102* endodermal cell differentiation (GO:0035987)3.35118489
103cellular response to cadmium ion (GO:0071276)3.33901500
104negative regulation of cytokine production involved in immune response (GO:0002719)3.32641282
105detection of external biotic stimulus (GO:0098581)3.31597612
106sphingolipid catabolic process (GO:0030149)3.28738823
107regulation of T-helper 2 cell differentiation (GO:0045628)3.27854868
108regulation of natural killer cell differentiation (GO:0032823)3.27369829
109defense response to Gram-positive bacterium (GO:0050830)3.26660460
110chronic inflammatory response (GO:0002544)3.24971120
111positive regulation of leukocyte degranulation (GO:0043302)3.22814908
112regulation of cholesterol storage (GO:0010885)3.22570758
113myeloid dendritic cell activation (GO:0001773)3.20763410
114leukocyte chemotaxis (GO:0030595)3.18708942
115N-acetylneuraminate metabolic process (GO:0006054)3.16511567
116positive regulation of monocyte chemotaxis (GO:0090026)3.14545717
117mucosal immune response (GO:0002385)3.13608233
118macrophage activation involved in immune response (GO:0002281)3.12614738
119eosinophil migration (GO:0072677)3.11728357
120regulation of membrane protein ectodomain proteolysis (GO:0051043)3.11608392
121regulation of T-helper 1 cell differentiation (GO:0045625)3.11405356
122positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.10831725
123germinal center formation (GO:0002467)3.10357834
124leukocyte degranulation (GO:0043299)3.09446749
125* macrophage differentiation (GO:0030225)3.08505108
126terpenoid biosynthetic process (GO:0016114)3.07521870
127regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.07296372
128leukotriene metabolic process (GO:0006691)3.04560780
129reactive oxygen species biosynthetic process (GO:1903409)3.03921281
130positive regulation of vesicle fusion (GO:0031340)3.03832098
131negative regulation of interleukin-12 production (GO:0032695)3.02353298
132leukotriene biosynthetic process (GO:0019370)3.02027846
133positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.01672488
134natural killer cell activation involved in immune response (GO:0002323)3.01635757
135cellular response to lipopolysaccharide (GO:0071222)3.01551777
136interferon-gamma-mediated signaling pathway (GO:0060333)3.01164697
137fat-soluble vitamin biosynthetic process (GO:0042362)3.00344855
138regulation of B cell differentiation (GO:0045577)2.99591841
139positive regulation of regulated secretory pathway (GO:1903307)2.98563367
140detection of molecule of bacterial origin (GO:0032490)2.98431051
141positive regulation of cellular amide metabolic process (GO:0034250)2.98041644
142decidualization (GO:0046697)2.96774818
143response to protozoan (GO:0001562)2.96510419
144organ or tissue specific immune response (GO:0002251)2.95542960
145cellular response to molecule of bacterial origin (GO:0071219)2.92725278
146positive regulation of lamellipodium organization (GO:1902745)2.92692024
147regulation of interferon-alpha production (GO:0032647)2.92649497
148positive regulation of antigen processing and presentation (GO:0002579)2.92586137
149virion attachment to host cell (GO:0019062)2.90244871
150adhesion of symbiont to host cell (GO:0044650)2.90244871
151response to muramyl dipeptide (GO:0032495)2.90062883
152actin nucleation (GO:0045010)2.89900571
153macrophage activation (GO:0042116)2.89396633
154dendritic cell differentiation (GO:0097028)2.88409563
155branching involved in labyrinthine layer morphogenesis (GO:0060670)2.87022227
156positive regulation of gamma-delta T cell activation (GO:0046645)2.85366245
157leukocyte mediated cytotoxicity (GO:0001909)2.85230941
158defense response to protozoan (GO:0042832)2.83559609
159barbed-end actin filament capping (GO:0051016)2.82835414
160positive regulation of NF-kappaB import into nucleus (GO:0042346)2.82811688
161myeloid cell activation involved in immune response (GO:0002275)2.82354695
162innate immune response in mucosa (GO:0002227)2.81867894
163regulation of heat generation (GO:0031650)2.80486605
164positive regulation of interleukin-6 production (GO:0032755)2.77557632
165regulation of antigen processing and presentation (GO:0002577)2.76952363
166cellular response to arsenic-containing substance (GO:0071243)2.76026650
167regulation of chronic inflammatory response (GO:0002676)2.74768248
168negative regulation of lipid storage (GO:0010888)2.73755429
169regulation of interleukin-12 production (GO:0032655)2.73506653
170negative regulation of erythrocyte differentiation (GO:0045647)2.72553062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.27257943
2MYB_21317192_ChIP-Seq_ERMYB_Mouse4.77619545
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.07227383
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.73978393
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.57296138
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.49291806
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.44683679
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.40604845
9* BRD4_27068464_Chip-Seq_AML-cells_Mouse3.24578837
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.24232988
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.22018616
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.80077490
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.77585771
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.72241622
15* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.58216700
16SPI1_23547873_ChIP-Seq_NB4_Human2.50773301
17* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30962808
18SPI1_23127762_ChIP-Seq_K562_Human2.24404771
19VDR_21846776_ChIP-Seq_THP-1_Human2.21041405
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11209918
21RUNX1_22412390_ChIP-Seq_EML_Mouse2.07614534
22VDR_24763502_ChIP-Seq_THP-1_Human2.01417291
23SCL_19346495_ChIP-Seq_HPC-7_Human1.92168910
24MAF_26560356_Chip-Seq_TH1_Human1.91455874
25RUNX_20019798_ChIP-Seq_JUKART_Human1.91359904
26* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87762559
27* UTX_26944678_Chip-Seq_JUKART_Human1.84899490
28* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78739493
29* MYB_26560356_Chip-Seq_TH2_Human1.78374773
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77096343
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75793718
32TCF7_22412390_ChIP-Seq_EML_Mouse1.75706958
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75156743
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.72286448
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68291249
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68187355
37VDR_24787735_ChIP-Seq_THP-1_Human1.64334187
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63681325
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62295734
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62085110
41PU_27001747_Chip-Seq_BMDM_Mouse1.61923891
42* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59345155
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58678596
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54519656
45MYB_26560356_Chip-Seq_TH1_Human1.51512100
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.48922056
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48600139
48* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45635699
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.43706610
50PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43228401
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43219333
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40826959
53* KDM2B_26808549_Chip-Seq_DND41_Human1.39924789
54CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39921418
55GATA3_27048872_Chip-Seq_THYMUS_Human1.38437781
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.36836039
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35006966
58* LXR_22292898_ChIP-Seq_THP-1_Human1.34555444
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33300022
60TFEB_21752829_ChIP-Seq_HELA_Human1.30888586
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28295952
62GATA2_19941826_ChIP-Seq_K562_Human1.27676531
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23630111
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22454876
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22325385
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20905347
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20748856
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.20572731
69GATA1_19941826_ChIP-Seq_K562_Human1.20455095
70GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20315268
71GATA1_22025678_ChIP-Seq_K562_Human1.18789272
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17751306
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17645878
74GATA3_26560356_Chip-Seq_TH2_Human1.16319668
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15398416
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.14726910
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14572638
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13117884
79STAT1_20625510_ChIP-Seq_HELA_Human1.12802554
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11979412
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09601611
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09219999
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.07492579
84MAF_26560356_Chip-Seq_TH2_Human1.06888349
85BCOR_27268052_Chip-Seq_Bcells_Human1.05272465
86MYC_22102868_ChIP-Seq_BL_Human1.03408514
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03010160
88* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02955319
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02943145
90* BCL6_27268052_Chip-Seq_Bcells_Human1.02593578
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02393895
92RACK7_27058665_Chip-Seq_MCF-7_Human1.02122987
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01880337
94SPI1_20517297_ChIP-Seq_HL60_Human1.01605637
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01521539
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00062795
97PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98378284
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97624376
99* KDM2B_26808549_Chip-Seq_JURKAT_Human0.96972935
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96677881
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96647709
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96398516
103IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95772789
104CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95365114
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95319437
106FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95142672
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93730195
108GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93127879
109CLOCK_20551151_ChIP-Seq_293T_Human0.93052592
110* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92619317
111* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91905569
112RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91832711
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90041591
114ELF1_20517297_ChIP-Seq_JURKAT_Human0.89938477
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89320788
116TP63_17297297_ChIP-ChIP_HaCaT_Human0.89075382
117JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88865297
118PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86845612
119* KDM2B_26808549_Chip-Seq_K562_Human0.86653892
120SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85588007
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83651592
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83371710
123RXR_22158963_ChIP-Seq_LIVER_Mouse0.82533246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.83824953
2* MP0003436_decreased_susceptibility_to4.66289554
3* MP0002419_abnormal_innate_immunity3.80652368
4MP0009840_abnormal_foam_cell3.71472273
5MP0003724_increased_susceptibility_to3.29506333
6* MP0009785_altered_susceptibility_to3.22551110
7MP0003183_abnormal_peptide_metabolism3.17788915
8MP0002139_abnormal_hepatobiliary_system3.05568318
9* MP0001533_abnormal_skeleton_physiology2.83265776
10* MP0005025_abnormal_response_to2.76103510
11MP0003300_gastrointestinal_ulcer2.50860296
12MP0002277_abnormal_respiratory_mucosa2.48230458
13MP0000685_abnormal_immune_system2.43411269
14MP0003828_pulmonary_edema2.42780178
15MP0001835_abnormal_antigen_presentation2.32145018
16* MP0005000_abnormal_immune_tolerance2.26543932
17* MP0009278_abnormal_bone_marrow2.21853040
18MP0005464_abnormal_platelet_physiology2.16895111
19* MP0001819_abnormal_immune_cell2.15107044
20* MP0002452_abnormal_antigen_presenting2.13597862
21* MP0002420_abnormal_adaptive_immunity2.13206794
22MP0004510_myositis2.11341582
23MP0002396_abnormal_hematopoietic_system2.09566138
24MP0001851_eye_inflammation2.04855247
25* MP0001845_abnormal_inflammatory_respons1.99509379
26* MP0002405_respiratory_system_inflammati1.98239215
27* MP0002148_abnormal_hypersensitivity_rea1.97529787
28* MP0000343_altered_response_to1.96878773
29MP0005451_abnormal_body_composition1.96688247
30MP0000465_gastrointestinal_hemorrhage1.93047450
31MP0005076_abnormal_cell_differentiation1.91421031
32MP0003191_abnormal_cellular_cholesterol1.88603494
33* MP0001800_abnormal_humoral_immune1.87329101
34MP0005387_immune_system_phenotype1.86607971
35MP0001790_abnormal_immune_system1.86607971
36MP0003566_abnormal_cell_adhesion1.85923049
37* MP0002723_abnormal_immune_serum1.83903954
38* MP0000858_altered_metastatic_potential1.73628010
39MP0002254_reproductive_system_inflammat1.73299225
40MP0005310_abnormal_salivary_gland1.72011926
41MP0003690_abnormal_glial_cell1.68024123
42MP0001958_emphysema1.67073663
43* MP0009764_decreased_sensitivity_to1.65374298
44* MP0003075_altered_response_to1.63988267
45MP0008260_abnormal_autophagy1.60453049
46MP0004947_skin_inflammation1.59639740
47* MP0005023_abnormal_wound_healing1.58668816
48MP0003195_calcinosis1.56070253
49* MP0005390_skeleton_phenotype1.54611639
50* MP0000716_abnormal_immune_system1.44425478
51MP0008004_abnormal_stomach_pH1.40957741
52MP0005671_abnormal_response_to1.39976209
53MP0005058_abnormal_lysosome_morphology1.38003129
54* MP0003448_altered_tumor_morphology1.36983699
55MP0003705_abnormal_hypodermis_morpholog1.34742274
56* MP0002398_abnormal_bone_marrow1.33267694
57* MP0008469_abnormal_protein_level1.30974191
58* MP0004883_abnormal_blood_vessel1.23489752
59MP0002133_abnormal_respiratory_system1.20721577
60MP0005388_respiratory_system_phenotype1.20721577
61MP0003806_abnormal_nucleotide_metabolis1.19899562
62* MP0002429_abnormal_blood_cell1.18384528
63* MP0005164_abnormal_response_to1.16588306
64MP0002132_abnormal_respiratory_system1.16242766
65MP0000689_abnormal_spleen_morphology1.15290318
66* MP0005166_decreased_susceptibility_to1.14747251
67MP0006082_CNS_inflammation1.13887792
68* MP0005397_hematopoietic_system_phenotyp1.13735207
69* MP0001545_abnormal_hematopoietic_system1.13735207
70MP0003123_paternal_imprinting1.13392904
71MP0008438_abnormal_cutaneous_collagen1.09917097
72* MP0004808_abnormal_hematopoietic_stem1.09310553
73MP0006054_spinal_hemorrhage1.08979310
74MP0003950_abnormal_plasma_membrane1.08330897
75* MP0010155_abnormal_intestine_physiology1.08321431
76MP0000604_amyloidosis1.07366548
77MP0002722_abnormal_immune_system1.04792323
78* MP0002933_joint_inflammation1.03212819
79MP0003656_abnormal_erythrocyte_physiolo1.01142774
80MP0005365_abnormal_bile_salt0.98863979
81MP0001542_abnormal_bone_strength0.98782399
82MP0002998_abnormal_bone_remodeling0.98575317
83MP0010234_abnormal_vibrissa_follicle0.98105153
84MP0005165_increased_susceptibility_to0.97795954
85MP0002282_abnormal_trachea_morphology0.97785089
86MP0002060_abnormal_skin_morphology0.93771816
87MP0002332_abnormal_exercise_endurance0.91961159
88MP0000569_abnormal_digit_pigmentation0.90801565
89MP0003172_abnormal_lysosome_physiology0.88856446
90MP0001663_abnormal_digestive_system0.87544936
91MP0010307_abnormal_tumor_latency0.86034968
92* MP0003795_abnormal_bone_structure0.84696656
93MP0005647_abnormal_sex_gland0.84634042
94MP0003091_abnormal_cell_migration0.83329296
95* MP0005167_abnormal_blood-brain_barrier0.83186820
96MP0002877_abnormal_melanocyte_morpholog0.80849713
97MP0005257_abnormal_intraocular_pressure0.75873272
98* MP0000920_abnormal_myelination0.74895980
99* MP0003634_abnormal_glial_cell0.74563931
100MP0002090_abnormal_vision0.74185713
101MP0003329_amyloid_beta_deposits0.73614708
102MP0001849_ear_inflammation0.72745292
103MP0000371_diluted_coat_color0.72670788
104MP0000516_abnormal_urinary_system0.72178720
105MP0005367_renal/urinary_system_phenotyp0.72178720
106MP0009931_abnormal_skin_appearance0.70369722
107MP0002166_altered_tumor_susceptibility0.70288249
108* MP0009763_increased_sensitivity_to0.69242679
109MP0002928_abnormal_bile_duct0.69216974
110MP0001873_stomach_inflammation0.69129181
111MP0005319_abnormal_enzyme/_coenzyme0.68347692
112MP0002138_abnormal_hepatobiliary_system0.66140771
113MP0010352_gastrointestinal_tract_polyps0.65907215
114MP0002971_abnormal_brown_adipose0.65796536
115MP0009333_abnormal_splenocyte_physiolog0.65530236
116* MP0008874_decreased_physiological_sensi0.64184318
117* MP0001853_heart_inflammation0.63755492
118MP0003186_abnormal_redox_activity0.63655056
119MP0004381_abnormal_hair_follicle0.63650301
120MP0000703_abnormal_thymus_morphology0.63639601
121MP0002896_abnormal_bone_mineralization0.62398768
122MP0005174_abnormal_tail_pigmentation0.61836081
123* MP0003453_abnormal_keratinocyte_physiol0.61286545
124MP0005381_digestive/alimentary_phenotyp0.60625807
125* MP0000249_abnormal_blood_vessel0.59162518
126MP0000609_abnormal_liver_physiology0.58968491
127* MP0009765_abnormal_xenobiotic_induced0.58774256
128MP0005248_abnormal_Harderian_gland0.57740728
129* MP0005595_abnormal_vascular_smooth0.54109024
130MP0005584_abnormal_enzyme/coenzyme_acti0.54045682

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)9.12412064
2Eczematoid dermatitis (HP:0000976)8.79510455
3Recurrent gram-negative bacterial infections (HP:0005420)8.32692711
4Abnormality of liposaccharide metabolism (HP:0010968)8.28936859
5Abnormality of glycosphingolipid metabolism (HP:0004343)8.28936859
6Abnormality of glycolipid metabolism (HP:0010969)8.28936859
7Recurrent bacterial skin infections (HP:0005406)7.54276842
8Abnormality of macrophages (HP:0004311)6.16244914
9Chronic obstructive pulmonary disease (HP:0006510)5.63987056
10Obstructive lung disease (HP:0006536)5.63987056
11Stomatitis (HP:0010280)5.60778574
12Gingivitis (HP:0000230)5.39002158
13Mediastinal lymphadenopathy (HP:0100721)5.21252384
14Disinhibition (HP:0000734)5.05800685
15Urticaria (HP:0001025)4.79565326
16Loss of speech (HP:0002371)4.68536041
17Mutism (HP:0002300)4.60273727
18Recurrent skin infections (HP:0001581)4.43854405
19Spontaneous hematomas (HP:0007420)4.36442688
20Myositis (HP:0100614)4.24533026
21Cellulitis (HP:0100658)4.11135367
22Recurrent fungal infections (HP:0002841)4.05716029
23Neurofibrillary tangles (HP:0002185)3.94337769
24Abnormality of mucopolysaccharide metabolism (HP:0011020)3.87064969
25Abnormality of polysaccharide metabolism (HP:0011012)3.87064969
26Abnormality of glycosaminoglycan metabolism (HP:0004371)3.87064969
27Nuclear cataract (HP:0100018)3.63964839
28Orchitis (HP:0100796)3.59989679
29Peritonitis (HP:0002586)3.57269187
30Hepatosplenomegaly (HP:0001433)3.55058359
31Thickened calvaria (HP:0002684)3.47745093
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.42946099
33Glomerulonephritis (HP:0000099)3.42459597
34Abnormality of the vasculature of the conjunctiva (HP:0008054)3.22644998
35Abnormal platelet volume (HP:0011876)3.15471874
36Meningitis (HP:0001287)3.10185722
37Apathy (HP:0000741)3.06480271
38Agnosia (HP:0010524)3.06461098
39Diminished motivation (HP:0000745)3.04014495
40Hematochezia (HP:0002573)2.96712741
41Upper motor neuron abnormality (HP:0002127)2.90842213
42Inappropriate behavior (HP:0000719)2.87762255
43Periodontitis (HP:0000704)2.84018389
44Cerebral inclusion bodies (HP:0100314)2.83730809
45Neuronal loss in central nervous system (HP:0002529)2.75323403
46Elevated erythrocyte sedimentation rate (HP:0003565)2.71644196
47Myocardial infarction (HP:0001658)2.71523674
48Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.71314764
49Abnormality of iron homeostasis (HP:0011031)2.61656883
50Gingival bleeding (HP:0000225)2.59515733
51Progressive neurologic deterioration (HP:0002344)2.59093293
52Vacuolated lymphocytes (HP:0001922)2.53220893
53Complement deficiency (HP:0004431)2.53115622
54Increased mean platelet volume (HP:0011877)2.52243612
55Interstitial pulmonary disease (HP:0006530)2.47886251
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.45659332
57Recurrent cutaneous fungal infections (HP:0011370)2.45632358
58Chronic mucocutaneous candidiasis (HP:0002728)2.45632358
59Personality changes (HP:0000751)2.42718707
60Retinal atrophy (HP:0001105)2.41069523
61Pustule (HP:0200039)2.40457695
62Episodic fever (HP:0001954)2.34928816
63Dementia (HP:0000726)2.34254839
64Prolonged neonatal jaundice (HP:0006579)2.33370250
65Skin ulcer (HP:0200042)2.33361333
66Sepsis (HP:0100806)2.30356623
67Pathologic fracture (HP:0002756)2.29577683
68Prolonged bleeding time (HP:0003010)2.28210977
69Pulmonary embolism (HP:0002204)2.28141340
70Osteomyelitis (HP:0002754)2.27230767
71Systemic lupus erythematosus (HP:0002725)2.26655704
72Keratoconjunctivitis sicca (HP:0001097)2.26115871
73Inflammation of the large intestine (HP:0002037)2.22366793
74Increased cerebral lipofuscin (HP:0011813)2.20395934
75Retrobulbar optic neuritis (HP:0100654)2.19806733
76Optic neuritis (HP:0100653)2.19806733
77Malnutrition (HP:0004395)2.18363250
78Leukocytosis (HP:0001974)2.18002976
79Abnormality of transition element cation homeostasis (HP:0011030)2.17908437
80Protrusio acetabuli (HP:0003179)2.17803219
81Bone pain (HP:0002653)2.17282004
82Epistaxis (HP:0000421)2.16988933
83Premature rupture of membranes (HP:0001788)2.16860731
84Hypermelanotic macule (HP:0001034)2.14444748
85Nausea (HP:0002018)2.13859600
86Pulmonary infiltrates (HP:0002113)2.11905358
87Vasculitis (HP:0002633)2.11665540
88Conjunctival telangiectasia (HP:0000524)2.11226689
89Gastrointestinal inflammation (HP:0004386)2.11067489
90* Metaphyseal irregularity (HP:0003025)2.10600308
91Asymmetric septal hypertrophy (HP:0001670)2.10293471
92Recurrent pneumonia (HP:0006532)2.09367468
93Increased serum ferritin (HP:0003281)2.08668947
94Absent frontal sinuses (HP:0002688)2.08189984
95Persistence of primary teeth (HP:0006335)2.07841033
96Amyloidosis (HP:0011034)2.06998824
97Increased IgE level (HP:0003212)2.06827612
98Spondylolisthesis (HP:0003302)2.06670195
99Basal ganglia calcification (HP:0002135)2.06656461
100Petechiae (HP:0000967)2.05858805
101Increased neuronal autofluorescent lipopigment (HP:0002074)2.05840709
102Nonimmune hydrops fetalis (HP:0001790)2.05583539
103Hemoptysis (HP:0002105)2.05133274
104Abnormality of the peritoneum (HP:0002585)2.04233707
105Asymmetry of the thorax (HP:0001555)2.03754011
106Keratoconjunctivitis (HP:0001096)2.03719028
107Abnormality of the common coagulation pathway (HP:0010990)2.02808320
108Polyneuropathy (HP:0001271)2.02659440
109Thoracic kyphosis (HP:0002942)2.02469715
110Dysostosis multiplex (HP:0000943)2.02047504
111Supranuclear gaze palsy (HP:0000605)1.99808930
112Chest pain (HP:0100749)1.99793639
113Abnormality of complement system (HP:0005339)1.95845133
114Peripheral demyelination (HP:0011096)1.94776823
115Recurrent lower respiratory tract infections (HP:0002783)1.93856536
116Cheilitis (HP:0100825)1.93345627
117Papilledema (HP:0001085)1.92038818
118Elevated alkaline phosphatase (HP:0003155)1.92027033
119Osteolytic defects of the phalanges of the hand (HP:0009771)1.89753595
120Osteolytic defects of the hand bones (HP:0009699)1.89753595
121Progressive visual loss (HP:0000529)1.89381198
122Cardiomegaly (HP:0001640)1.89086436
123Arterial thrombosis (HP:0004420)1.88330539
124Biconcave vertebral bodies (HP:0004586)1.87642288
125Memory impairment (HP:0002354)1.86979601
126Thin bony cortex (HP:0002753)1.86873403
127Abnormality of the nasal mucosa (HP:0000433)1.83061458
128Chronic otitis media (HP:0000389)1.82944944
129Purpura (HP:0000979)1.81885369
130Autoimmune thrombocytopenia (HP:0001973)1.80751080
131Premature loss of primary teeth (HP:0006323)1.80499644
132Genu recurvatum (HP:0002816)1.79496377
133Recurrent viral infections (HP:0004429)1.79027062
134Increased IgM level (HP:0003496)1.78814146
135Abnormality of the periventricular white matter (HP:0002518)1.78761758
136T lymphocytopenia (HP:0005403)1.78245643
137Protuberant abdomen (HP:0001538)1.78169124
138Abnormality of alkaline phosphatase activity (HP:0004379)1.74481081
139Encephalitis (HP:0002383)1.72117445
140Abnormal foot bone ossification (HP:0010675)1.71842489
141Restrictive lung disease (HP:0002091)1.71119295
142Abnormal enzyme/coenzyme activity (HP:0012379)1.69545287
143Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69474025
144Verrucae (HP:0200043)1.68899096
145Papilloma (HP:0012740)1.68899096
146Xanthomatosis (HP:0000991)1.66594303
147IgM deficiency (HP:0002850)1.66010177
148Multiple enchondromatosis (HP:0005701)1.65853409
149Abnormality of the frontal sinuses (HP:0002687)1.64606144
150Axonal loss (HP:0003447)1.63849324
151Vertebral compression fractures (HP:0002953)1.61595989
152Menorrhagia (HP:0000132)1.60996572
153Dilatation of the ascending aorta (HP:0005111)1.60581133
154Ulnar bowing (HP:0003031)1.60048107
155Urinary glycosaminoglycan excretion (HP:0003541)1.59836228
156Mucopolysacchariduria (HP:0008155)1.59836228
157Impaired platelet aggregation (HP:0003540)1.56198178
158Abnormal platelet function (HP:0011869)1.56198178

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.70559071
2IRAK34.62014832
3EPHB14.17207751
4ERN13.60099229
5IRAK43.58361920
6FGR3.06684783
7DDR22.99723546
8MAP2K32.98403556
9CSK2.97831308
10BTK2.88432345
11TRPM72.87477767
12MAP3K142.87390261
13TAOK22.78884995
14TEC2.77323562
15RIPK42.76731558
16TRIB32.63507824
17BLK2.60781917
18STK102.59210668
19ERBB32.54266289
20MAP3K32.21022850
21HCK2.14454447
22PTK22.11793444
23FES2.09157447
24GRK62.08833658
25MAP3K122.01545384
26LRRK21.93610505
27KSR21.91670741
28CLK11.90964836
29ITK1.90021621
30PIM21.87773716
31TGFBR21.83113125
32MAP3K91.81349644
33ACVR1B1.80167774
34IKBKB1.79236408
35PTK61.79120321
36TESK21.70128148
37PRPF4B1.62196932
38PRKG21.56962826
39PAK41.56869279
40CAMKK21.56086664
41CDC42BPA1.48409634
42ABL21.47695268
43IKBKE1.46855428
44PKN21.33246931
45KDR1.31297274
46TTN1.27639403
47ADRBK21.26863455
48TYK21.26786569
49ALK1.20385144
50MAP3K131.20356691
51FRK1.18448548
52TAOK11.08116043
53TXK1.07668200
54RIPK11.01814655
55TESK11.00888987
56MAP3K111.00248052
57PTK2B0.95513270
58MAP3K50.93866484
59CHUK0.92742080
60ZAP700.91471040
61TYRO30.90922149
62MAP4K10.89411705
63TGFBR10.85326469
64MOS0.83239932
65ARAF0.76286021
66MARK30.74578251
67RPS6KA40.74366697
68GRK10.72634748
69MAPKAPK20.72414119
70JAK10.70780548
71BMPR20.69712719
72LIMK10.69238569
73IRAK20.67856615
74SIK30.67550494
75TBK10.67343257
76CSF1R0.66709569
77MATK0.65914872
78JAK20.65446318
79DAPK20.65394379
80MAP3K10.64115498
81CAMK1G0.62570660
82PRKCH0.62066298
83RAF10.62009434
84TNK20.60987394
85DMPK0.60808325
86FYN0.60365363
87EPHA30.57865510
88GRK70.56769509
89SYK0.56358018
90LYN0.56066794
91PDGFRA0.54721044
92GRK50.52834839
93STK110.52486031
94NEK90.52312434
95PRKCD0.49379095
96EPHB20.47281503
97LCK0.47241955
98MAP2K20.47022992
99EGFR0.46110848
100CDK60.45604566
101PDK10.45093759
102IRAK10.44254506
103PDPK10.44235924
104RPS6KA20.42580685
105MAP3K80.41516347
106MAPK40.41346914
107MAP2K60.41214811
108CAMKK10.40007655
109MAP3K100.38901009
110ICK0.38848392
111KSR10.38357162
112DYRK30.37842753
113PIK3CG0.36242278
114FGFR30.35823061
115ILK0.35463980
116SIK20.35209482
117PAK30.34285993
118ADRBK10.34248738
119FGFR10.34128945
120SGK30.33346049
121BMX0.32547258
122PRKAA20.31980285
123ABL10.31580870
124DAPK30.29875183
125MST40.29665018
126KIT0.28970392
127CAMK1D0.28837400
128MAP3K20.28413802
129PDGFRB0.26542970
130FGFR40.26461017
131ROCK20.26109063
132LATS20.25446128
133INSR0.24939110
134SIK10.24466780
135SRC0.24143063
136MAP2K10.23880941
137JAK30.23667457
138RPS6KA60.23491735
139FGFR20.22995352
140RPS6KA10.22862915
141RPS6KL10.22504771
142RPS6KC10.22504771
143MAPK70.22306406
144MARK20.21888175
145PIM10.21140610
146IGF1R0.20982400

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.29736486
2Leishmaniasis_Homo sapiens_hsa051403.67979025
3Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.65798611
4* Leukocyte transendothelial migration_Homo sapiens_hsa046702.59371087
5Osteoclast differentiation_Homo sapiens_hsa043802.56756288
6Caffeine metabolism_Homo sapiens_hsa002322.45341634
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.27037601
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.18315132
9Shigellosis_Homo sapiens_hsa051312.10298526
10Allograft rejection_Homo sapiens_hsa053302.04799986
11Chemokine signaling pathway_Homo sapiens_hsa040622.01232664
12Tuberculosis_Homo sapiens_hsa051521.83833246
13Pertussis_Homo sapiens_hsa051331.82355146
14Graft-versus-host disease_Homo sapiens_hsa053321.81013018
15B cell receptor signaling pathway_Homo sapiens_hsa046621.74972847
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73075138
17Salmonella infection_Homo sapiens_hsa051321.70968148
18Hematopoietic cell lineage_Homo sapiens_hsa046401.68265206
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.64459775
20Collecting duct acid secretion_Homo sapiens_hsa049661.61011318
21Autoimmune thyroid disease_Homo sapiens_hsa053201.59854601
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.54654643
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53943928
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52822028
25VEGF signaling pathway_Homo sapiens_hsa043701.49935341
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49014422
27Acute myeloid leukemia_Homo sapiens_hsa052211.49011942
28Platelet activation_Homo sapiens_hsa046111.48514509
29Antigen processing and presentation_Homo sapiens_hsa046121.48173276
30Histidine metabolism_Homo sapiens_hsa003401.46461142
31Mineral absorption_Homo sapiens_hsa049781.43929412
32Legionellosis_Homo sapiens_hsa051341.41528591
33Prion diseases_Homo sapiens_hsa050201.36626998
34Type I diabetes mellitus_Homo sapiens_hsa049401.35349972
35Toxoplasmosis_Homo sapiens_hsa051451.35103959
36Amoebiasis_Homo sapiens_hsa051461.33183687
37Malaria_Homo sapiens_hsa051441.32773060
38Phagosome_Homo sapiens_hsa041451.31064708
39Pancreatic cancer_Homo sapiens_hsa052121.29696122
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21984381
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15330245
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.13156041
43Pentose phosphate pathway_Homo sapiens_hsa000301.11029460
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10729020
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09533480
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.09423449
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.08348621
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07009580
49Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06443285
50Sphingolipid signaling pathway_Homo sapiens_hsa040711.04045635
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03097101
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02962899
53Non-small cell lung cancer_Homo sapiens_hsa052231.02773279
54Insulin resistance_Homo sapiens_hsa049311.02501673
55Asthma_Homo sapiens_hsa053101.01600853
56Viral myocarditis_Homo sapiens_hsa054161.01591775
57Chronic myeloid leukemia_Homo sapiens_hsa052201.00610832
58Vibrio cholerae infection_Homo sapiens_hsa051100.98282801
59* TNF signaling pathway_Homo sapiens_hsa046680.97141977
60Rap1 signaling pathway_Homo sapiens_hsa040150.93738017
61Rheumatoid arthritis_Homo sapiens_hsa053230.90920555
62Focal adhesion_Homo sapiens_hsa045100.89115583
63Sphingolipid metabolism_Homo sapiens_hsa006000.88516856
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87330332
65Renal cell carcinoma_Homo sapiens_hsa052110.86096829
66Endocytosis_Homo sapiens_hsa041440.85613798
67Starch and sucrose metabolism_Homo sapiens_hsa005000.84070699
68Dorso-ventral axis formation_Homo sapiens_hsa043200.82939529
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80208155
70Complement and coagulation cascades_Homo sapiens_hsa046100.79757643
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75379741
72Adherens junction_Homo sapiens_hsa045200.75086886
73Galactose metabolism_Homo sapiens_hsa000520.75033177
74* Hepatitis B_Homo sapiens_hsa051610.74761802
75Influenza A_Homo sapiens_hsa051640.74070043
76Glioma_Homo sapiens_hsa052140.72944958
77* Proteoglycans in cancer_Homo sapiens_hsa052050.72324726
78* Bladder cancer_Homo sapiens_hsa052190.70707854
79Measles_Homo sapiens_hsa051620.68807035
80Lysosome_Homo sapiens_hsa041420.66665085
81Prolactin signaling pathway_Homo sapiens_hsa049170.66398641
82Hepatitis C_Homo sapiens_hsa051600.66241057
83Apoptosis_Homo sapiens_hsa042100.65717742
84Sulfur metabolism_Homo sapiens_hsa009200.64655282
85T cell receptor signaling pathway_Homo sapiens_hsa046600.62750959
86Retinol metabolism_Homo sapiens_hsa008300.62241500
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62137124
88Colorectal cancer_Homo sapiens_hsa052100.61888339
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.61731840
90Insulin signaling pathway_Homo sapiens_hsa049100.60050752
91FoxO signaling pathway_Homo sapiens_hsa040680.59585722
92Other glycan degradation_Homo sapiens_hsa005110.58188431
93MAPK signaling pathway_Homo sapiens_hsa040100.58104083
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.57361180
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56909639
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.56652728
97Endometrial cancer_Homo sapiens_hsa052130.55782610
98Epstein-Barr virus infection_Homo sapiens_hsa051690.54185760
99PPAR signaling pathway_Homo sapiens_hsa033200.54013632
100Primary immunodeficiency_Homo sapiens_hsa053400.53924991
101Synaptic vesicle cycle_Homo sapiens_hsa047210.53626681
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49157236
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.48251416
104* Estrogen signaling pathway_Homo sapiens_hsa049150.47893130
105Fructose and mannose metabolism_Homo sapiens_hsa000510.47442309
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45597494
107African trypanosomiasis_Homo sapiens_hsa051430.44351352
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.41107630
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40688349
110* Pathways in cancer_Homo sapiens_hsa052000.40085902
111Type II diabetes mellitus_Homo sapiens_hsa049300.39316356
112Long-term depression_Homo sapiens_hsa047300.39028386
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38862798
114GnRH signaling pathway_Homo sapiens_hsa049120.38737405
115HIF-1 signaling pathway_Homo sapiens_hsa040660.36606479
116Choline metabolism in cancer_Homo sapiens_hsa052310.36183990
117Renin-angiotensin system_Homo sapiens_hsa046140.34977631
118Herpes simplex infection_Homo sapiens_hsa051680.34596246
119* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34240583
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32747376
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32552681
122mTOR signaling pathway_Homo sapiens_hsa041500.32053978
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.31667311
124Renin secretion_Homo sapiens_hsa049240.29706800
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25887456
126HTLV-I infection_Homo sapiens_hsa051660.24835671
127Glutathione metabolism_Homo sapiens_hsa004800.24529585
128Systemic lupus erythematosus_Homo sapiens_hsa053220.19727809
129Notch signaling pathway_Homo sapiens_hsa043300.18597974
130Tryptophan metabolism_Homo sapiens_hsa003800.17318037
131Viral carcinogenesis_Homo sapiens_hsa052030.15696752

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