MMRN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fucose catabolic process (GO:0019317)8.42674782
2L-fucose metabolic process (GO:0042354)8.42674782
3L-fucose catabolic process (GO:0042355)8.42674782
4positive regulation of endothelial cell differentiation (GO:0045603)8.14268340
5definitive hemopoiesis (GO:0060216)8.12651075
6ribosomal small subunit assembly (GO:0000028)7.57446995
7lymphangiogenesis (GO:0001946)7.19742238
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.56413854
9regulation of endothelial cell differentiation (GO:0045601)6.28686424
10retina vasculature morphogenesis in camera-type eye (GO:0061299)6.14425138
11wound healing, spreading of epidermal cells (GO:0035313)6.10592535
12angiogenesis involved in wound healing (GO:0060055)6.07467748
13negative regulation of fibroblast apoptotic process (GO:2000270)6.03207261
14negative regulation of focal adhesion assembly (GO:0051895)5.75965710
15negative regulation of cell junction assembly (GO:1901889)5.75965710
16negative regulation of adherens junction organization (GO:1903392)5.75965710
17negative regulation of erythrocyte differentiation (GO:0045647)5.74710826
18mature B cell differentiation involved in immune response (GO:0002313)5.65313525
19viral transcription (GO:0019083)5.59987037
20endothelial tube morphogenesis (GO:0061154)5.54866489
21morphogenesis of an endothelium (GO:0003159)5.54866489
22artery development (GO:0060840)5.51185307
23negative regulation of blood vessel endothelial cell migration (GO:0043537)5.50233365
24platelet dense granule organization (GO:0060155)5.37543836
25hepatocyte apoptotic process (GO:0097284)5.26458231
26translational termination (GO:0006415)5.18656906
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.11918863
28megakaryocyte development (GO:0035855)5.09231454
29positive regulation of urine volume (GO:0035810)4.98844092
30cellular extravasation (GO:0045123)4.93689227
31response to interferon-beta (GO:0035456)4.92571217
32antigen processing and presentation via MHC class Ib (GO:0002475)4.89540134
33negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.78306104
34phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.76203264
35maturation of SSU-rRNA (GO:0030490)4.74656586
36thrombin receptor signaling pathway (GO:0070493)4.73981217
37sprouting angiogenesis (GO:0002040)4.71057167
38response to interferon-alpha (GO:0035455)4.64506437
39fucosylation (GO:0036065)4.55602192
40Peyers patch development (GO:0048541)4.50150638
41mucosal-associated lymphoid tissue development (GO:0048537)4.50150638
42mast cell activation involved in immune response (GO:0002279)4.49341981
43mast cell degranulation (GO:0043303)4.49341981
44translational elongation (GO:0006414)4.42552592
45fucose metabolic process (GO:0006004)4.41587988
46negative regulation of endothelial cell migration (GO:0010596)4.36158948
47positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)4.34694763
48lymph vessel development (GO:0001945)4.33417272
49positive regulation of gamma-delta T cell activation (GO:0046645)4.29988171
50positive regulation of granulocyte differentiation (GO:0030854)4.28114029
51ribosomal small subunit biogenesis (GO:0042274)4.27178264
52mature B cell differentiation (GO:0002335)4.24416126
53SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.24132357
54lymph node development (GO:0048535)4.19617595
55negative regulation of platelet activation (GO:0010544)4.19617053
56cotranslational protein targeting to membrane (GO:0006613)4.13396041
57protein targeting to ER (GO:0045047)4.10834652
58neuron remodeling (GO:0016322)4.07745046
59histamine secretion (GO:0001821)4.07651831
60secretory granule organization (GO:0033363)4.07180144
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.05945481
62positive regulation of interleukin-8 secretion (GO:2000484)4.05044234
63mast cell activation (GO:0045576)4.02269301
64blood coagulation, intrinsic pathway (GO:0007597)4.01628921
65necroptotic process (GO:0070266)4.01026761
66positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-4.00398477
67wound healing, spreading of cells (GO:0044319)3.99736199
68endothelial cell differentiation (GO:0045446)3.98874767
69regulation of fibroblast apoptotic process (GO:2000269)3.97805558
70negative regulation of neurological system process (GO:0031645)3.97277022
71plasma membrane fusion (GO:0045026)3.95515464
72IMP metabolic process (GO:0046040)3.94070594
73protein localization to endoplasmic reticulum (GO:0070972)3.93802624
74establishment of protein localization to endoplasmic reticulum (GO:0072599)3.93165368
75response to magnesium ion (GO:0032026)3.89664731
76viral life cycle (GO:0019058)3.85856634
77positive regulation of respiratory burst (GO:0060267)3.84716886
78regulation of integrin activation (GO:0033623)3.82960610
79regulation of histone H3-K9 methylation (GO:0051570)3.80910431
80endothelial cell proliferation (GO:0001935)3.80705211
81antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.76893858
82antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.76893858
83cellular protein complex disassembly (GO:0043624)3.75259600
84regulation of urine volume (GO:0035809)3.72918970
85regulation of establishment or maintenance of cell polarity (GO:0032878)3.72839493
86negative regulation of nitric-oxide synthase activity (GO:0051001)3.71867975
87positive regulation of hemostasis (GO:1900048)3.71494190
88positive regulation of blood coagulation (GO:0030194)3.71494190
89regulation of sarcomere organization (GO:0060297)3.70672097
90glomerular filtration (GO:0003094)3.70580916
91positive regulation of odontogenesis (GO:0042482)3.67635762
92embryonic hemopoiesis (GO:0035162)3.65736776
93regulation of platelet activation (GO:0010543)3.64902712
94negative regulation of viral entry into host cell (GO:0046597)3.64076604
95negative regulation of endothelial cell proliferation (GO:0001937)3.62866965
96regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.62753111
97regulation of chemokine-mediated signaling pathway (GO:0070099)3.59705941
98regulation of blood vessel endothelial cell migration (GO:0043535)3.59351941
99cAMP biosynthetic process (GO:0006171)3.59017769
100production of molecular mediator involved in inflammatory response (GO:0002532)3.57941557
101regulation of gamma-delta T cell differentiation (GO:0045586)3.54658414
102positive regulation of B cell differentiation (GO:0045579)3.54571300
103regulation of erythrocyte differentiation (GO:0045646)3.48140872
104positive regulation of fibroblast migration (GO:0010763)3.47868946
105myelin assembly (GO:0032288)3.47859861
106regulation of RIG-I signaling pathway (GO:0039535)3.47645418
107positive regulation of muscle hypertrophy (GO:0014742)3.44906166
108positive regulation of cardiac muscle hypertrophy (GO:0010613)3.44906166
109heparin biosynthetic process (GO:0030210)3.44706886
110heparin metabolic process (GO:0030202)3.44706886
111cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.44681714
112negative regulation of cell-matrix adhesion (GO:0001953)3.44371799
113CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.43199626
114positive regulation of chondrocyte differentiation (GO:0032332)3.42711271
115positive regulation of endothelial cell migration (GO:0010595)3.41588947
116regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.41452229
117negative regulation of viral genome replication (GO:0045071)3.39501723
118protein complex disassembly (GO:0043241)3.38555942
119artery smooth muscle contraction (GO:0014824)3.37507995
120translational initiation (GO:0006413)3.36927722
121regulation of endothelial cell migration (GO:0010594)3.36911879
122negative regulation of chondrocyte differentiation (GO:0032331)3.35684622
123programmed necrotic cell death (GO:0097300)3.35351988
124positive regulation of hormone biosynthetic process (GO:0046886)3.33677290
125negative regulation of fibrinolysis (GO:0051918)3.33284274
126positive regulation of vasculogenesis (GO:2001214)3.33017096
127positive regulation of coagulation (GO:0050820)3.32205247
128antigen processing and presentation of endogenous antigen (GO:0019883)3.30785116
129substrate-dependent cell migration (GO:0006929)3.30206226
130CD4-positive, alpha-beta T cell activation (GO:0035710)3.29231724
131negative regulation of histone methylation (GO:0031061)3.29154475
132regulation of natural killer cell differentiation (GO:0032823)3.28964489
133execution phase of apoptosis (GO:0097194)3.27673735
134angiogenesis (GO:0001525)3.26547928
135tonic smooth muscle contraction (GO:0014820)3.26429007
136positive regulation of receptor recycling (GO:0001921)3.24503714
137regulation of focal adhesion assembly (GO:0051893)3.22919165
138regulation of cell-substrate junction assembly (GO:0090109)3.22919165
139necrotic cell death (GO:0070265)3.22785500
140regulation of establishment of cell polarity (GO:2000114)3.20752413
141anatomical structure maturation (GO:0071695)3.20709339
142renal filtration (GO:0097205)3.20103487
143CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.19507857
144patterning of blood vessels (GO:0001569)3.17688130
145axon extension involved in axon guidance (GO:0048846)3.17657498
146neuron projection extension involved in neuron projection guidance (GO:1902284)3.17657498
147T cell homeostasis (GO:0043029)3.16872919
148response to protozoan (GO:0001562)3.16171618
149positive regulation of macrophage activation (GO:0043032)3.15941876
150positive regulation of endothelial cell apoptotic process (GO:2000353)3.15268889
151regulation of gamma-delta T cell activation (GO:0046643)3.14078022
152vascular endothelial growth factor signaling pathway (GO:0038084)3.12182699
153positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.12054133
154regulation of plasminogen activation (GO:0010755)3.11929234
155regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.09077152
156histamine transport (GO:0051608)3.08824098
157macromolecular complex disassembly (GO:0032984)3.08314928
158detection of other organism (GO:0098543)3.07788029
159defense response to protozoan (GO:0042832)3.06360091
160nephron epithelium development (GO:0072009)3.05859801
161regulation of adherens junction organization (GO:1903391)3.05712863
162endochondral ossification (GO:0001958)3.04884290
163replacement ossification (GO:0036075)3.04884290
164phospholipid scrambling (GO:0017121)2.99618028
165negative regulation of epithelial cell migration (GO:0010633)2.99576215
166positive regulation of steroid hormone secretion (GO:2000833)2.99556646
167negative regulation of angiogenesis (GO:0016525)2.99046108
168toxin transport (GO:1901998)2.99038375
169regulation of chondrocyte differentiation (GO:0032330)2.98977070
170negative regulation of transcription by competitive promoter binding (GO:0010944)2.98907301
171nuclear-transcribed mRNA catabolic process (GO:0000956)2.97696049
172negative regulation of DNA biosynthetic process (GO:2000279)2.96994524
173vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.96136723
174regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.95597670
175endocrine process (GO:0050886)2.95597670
176regulation of systemic arterial blood pressure by hormone (GO:0001990)2.95597670
177vascular smooth muscle contraction (GO:0014829)2.95235452
178positive regulation of cell size (GO:0045793)2.95039893
179regulation of granulocyte differentiation (GO:0030852)2.93293780
180blood vessel maturation (GO:0001955)2.92901561
181regulation of interleukin-12 biosynthetic process (GO:0045075)2.92488346
182hyaluronan catabolic process (GO:0030214)2.92320562
183mRNA catabolic process (GO:0006402)2.87737867
184positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.84098793
185lymphoid progenitor cell differentiation (GO:0002320)2.81580646
186regulation of viral entry into host cell (GO:0046596)2.78787109
187response to type I interferon (GO:0034340)2.76111355
188negative regulation of nitric oxide biosynthetic process (GO:0045019)2.75418392
189cellular response to type I interferon (GO:0071357)2.72568641
190type I interferon signaling pathway (GO:0060337)2.72568641
191regulation of histone H3-K4 methylation (GO:0051569)2.71353630
192B cell mediated immunity (GO:0019724)2.70283665
193regulation of regulatory T cell differentiation (GO:0045589)2.68333643
194endosome to melanosome transport (GO:0035646)2.68043178
195endosome to pigment granule transport (GO:0043485)2.68043178
196endothelium development (GO:0003158)11.7271678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human6.77057177
2E2F7_22180533_ChIP-Seq_HELA_Human4.23895504
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.88284719
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.85831309
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.76681834
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.61664029
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.52417549
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.39968745
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.34386427
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.05158155
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.02182195
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.89603054
13TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.89442836
14GATA2_21666600_ChIP-Seq_HMVEC_Human2.84813241
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.80607477
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.80303442
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.78043725
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.69135292
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.68738929
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.59101218
21MYC_22102868_ChIP-Seq_BL_Human2.56755131
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.55160178
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.52842967
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.51985855
25SPI1_23547873_ChIP-Seq_NB4_Human2.40245627
26LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.37159897
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.29490580
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25818331
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.15502273
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.14439655
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.13755446
32HOXB4_20404135_ChIP-ChIP_EML_Mouse2.08906150
33* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07399999
34TP63_19390658_ChIP-ChIP_HaCaT_Human2.05415585
35VDR_21846776_ChIP-Seq_THP-1_Human2.05028044
36TCF7_22412390_ChIP-Seq_EML_Mouse2.00818008
37GATA1_22383799_ChIP-Seq_G1ME_Mouse1.98126154
38GATA1_22025678_ChIP-Seq_K562_Human1.94957691
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91911183
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.91413644
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.91028284
42GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.88393469
43GATA2_22383799_ChIP-Seq_G1ME_Mouse1.85819867
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84953089
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83702561
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.81692548
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.80925999
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.77917091
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.77333720
50RUNX_20019798_ChIP-Seq_JUKART_Human1.73215766
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.71998933
52VDR_24763502_ChIP-Seq_THP-1_Human1.71747071
53P300_19829295_ChIP-Seq_ESCs_Human1.69874449
54MAF_26560356_Chip-Seq_TH1_Human1.69794088
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.69357118
56ZNF263_19887448_ChIP-Seq_K562_Human1.68278112
57VDR_22108803_ChIP-Seq_LS180_Human1.65428318
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65079671
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63580152
60CJUN_26792858_Chip-Seq_BT549_Human1.61786604
61GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.61613624
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.61472996
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.61472996
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.60691276
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.60445031
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.60384647
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.59150674
68GATA1_19941826_ChIP-Seq_K562_Human1.58839509
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58567166
70SPI1_23127762_ChIP-Seq_K562_Human1.58264646
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57088221
72STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55472366
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52629726
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51816348
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.51620077
76MYB_26560356_Chip-Seq_TH2_Human1.50492894
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49742233
78MYB_26560356_Chip-Seq_TH1_Human1.48882256
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47425168
80TAF15_26573619_Chip-Seq_HEK293_Human1.46907464
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46468116
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.44648225
83BRD4_25478319_ChIP-Seq_HGPS_Human1.44078820
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42005112
85FUS_26573619_Chip-Seq_HEK293_Human1.39389583
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37358239
87ETS1_22383799_ChIP-Seq_G1ME_Mouse1.36640600
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35358123
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34431730
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33551681
91PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.32454541
92SMAD4_21799915_ChIP-Seq_A2780_Human1.29511016
93EST1_17652178_ChIP-ChIP_JURKAT_Human1.29151169
94UTX_26944678_Chip-Seq_JUKART_Human1.29150451
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26593382
96* IGF1R_20145208_ChIP-Seq_DFB_Human1.25995064
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25736951
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25056117
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24064569
100EWS_26573619_Chip-Seq_HEK293_Human1.23302303
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22641141
102ZNF274_21170338_ChIP-Seq_K562_Hela1.22590417
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.22143695
104NCOR1_26117541_ChIP-Seq_K562_Human1.21312271
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20718819
106CIITA_25753668_ChIP-Seq_RAJI_Human1.18277143
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16039586
108SRF_21415370_ChIP-Seq_HL-1_Mouse1.15829286
109GBX2_23144817_ChIP-Seq_PC3_Human1.15103255
110MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13980165
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13557251
112IRF8_27001747_Chip-Seq_BMDM_Mouse1.13369295
113MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12660308
114FOXP3_21729870_ChIP-Seq_TREG_Human1.12607073
115VDR_23849224_ChIP-Seq_CD4+_Human1.12509359
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11742384
117VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11220860
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11178469
119BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10176549
120SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09917938
121LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09907677
122BCAT_22108803_ChIP-Seq_LS180_Human1.09011734
123ELK1_19687146_ChIP-ChIP_HELA_Human1.08314659
124XRN2_22483619_ChIP-Seq_HELA_Human1.07428095
125HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07291842
126PU_27001747_Chip-Seq_BMDM_Mouse1.07193226
127FOXO3_23340844_ChIP-Seq_DLD1_Human1.06739510
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05901546
129GATA2_19941826_ChIP-Seq_K562_Human1.05894413
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.05678128
131FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04941206
132NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02789237
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01843400
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00785039
135STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00525978
136* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00210897
137TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99868880
138FLI1_21867929_ChIP-Seq_TH2_Mouse0.99047823
139TP63_23658742_ChIP-Seq_EP156T_Human0.98363305
140CDX2_22108803_ChIP-Seq_LS180_Human0.98108409
141FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95937534
142STAT3_23295773_ChIP-Seq_U87_Human0.95651063
143GATA3_26560356_Chip-Seq_TH2_Human0.95311308
144SOX2_20726797_ChIP-Seq_SW620_Human0.94898516
145FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94361282
146NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93794805
147ER_23166858_ChIP-Seq_MCF-7_Human0.93413845
148FLI1_27457419_Chip-Seq_LIVER_Mouse0.93125356
149CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93009307
150EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92789785
151MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92626937
152TCF4_22108803_ChIP-Seq_LS180_Human0.92238308
153NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91850570
154TCF4_18268006_ChIP-ChIP_LS174T_Human0.91813568
155CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91775042
156SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91738178
157ELK4_26923725_Chip-Seq_MESODERM_Mouse0.91003113
158SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90944654
159TTF2_22483619_ChIP-Seq_HELA_Human0.89361093
160UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88725752
161SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87283084
162CDX2_20551321_ChIP-Seq_CACO-2_Human0.87024747
163EZH2_27294783_Chip-Seq_NPCs_Mouse0.87011266
164TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85538852
165MAF_26560356_Chip-Seq_TH2_Human0.85500593
166RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84803355
167E2F1_18555785_Chip-Seq_ESCs_Mouse0.84788521
168ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84301246
169TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84016054
170WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83896307
171FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83818307
172TBX20_22080862_ChIP-Seq_HEART_Mouse0.83754531
173TBX20_22328084_ChIP-Seq_HEART_Mouse0.83754531
174WT1_19549856_ChIP-ChIP_CCG9911_Human0.83749901
175THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82715813
176MYC_18940864_ChIP-ChIP_HL60_Human0.78819419
177RBPJ_22232070_ChIP-Seq_NCS_Mouse0.78480568
178ETS1_20019798_ChIP-Seq_JURKAT_Human0.77261489
179GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76246713
180PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.72908082

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005075_abnormal_melanosome_morpholog4.23580226
2MP0004272_abnormal_basement_membrane3.85741506
3MP0004808_abnormal_hematopoietic_stem3.85466776
4MP0003724_increased_susceptibility_to3.61165079
5MP0003303_peritoneal_inflammation3.59649467
6MP0010368_abnormal_lymphatic_system3.42981638
7MP0000465_gastrointestinal_hemorrhage3.33329717
8MP0002138_abnormal_hepatobiliary_system3.22730896
9MP0006054_spinal_hemorrhage3.22402149
10MP0002396_abnormal_hematopoietic_system3.21003037
11MP0003300_gastrointestinal_ulcer2.98030762
12MP0005464_abnormal_platelet_physiology2.92499907
13MP0009278_abnormal_bone_marrow2.82785277
14MP0009785_altered_susceptibility_to2.70696558
15MP0005084_abnormal_gallbladder_morpholo2.66947536
16MP0005397_hematopoietic_system_phenotyp2.60320904
17MP0001545_abnormal_hematopoietic_system2.60320904
18MP0001879_abnormal_lymphatic_vessel2.46111621
19MP0001835_abnormal_antigen_presentation2.39991521
20MP0000685_abnormal_immune_system2.33835419
21MP0005167_abnormal_blood-brain_barrier2.30188008
22MP0004147_increased_porphyrin_level2.29342809
23MP0005671_abnormal_response_to2.23811490
24MP0009379_abnormal_foot_pigmentation2.12586781
25MP0005174_abnormal_tail_pigmentation2.05720557
26MP0004084_abnormal_cardiac_muscle2.04906219
27MP0005595_abnormal_vascular_smooth1.96689148
28MP0003828_pulmonary_edema1.96641729
29MP0009697_abnormal_copulation1.93726736
30MP0003943_abnormal_hepatobiliary_system1.92510312
31MP0010155_abnormal_intestine_physiology1.89544536
32MP0003436_decreased_susceptibility_to1.85360358
33MP0005025_abnormal_response_to1.80321259
34MP0004484_altered_response_of1.79243089
35MP0002398_abnormal_bone_marrow1.78605350
36MP0000490_abnormal_crypts_of1.73004923
37MP0009780_abnormal_chondrocyte_physiolo1.72336700
38MP0002722_abnormal_immune_system1.66947635
39MP0003866_abnormal_defecation1.62428946
40MP0000689_abnormal_spleen_morphology1.61547459
41MP0002148_abnormal_hypersensitivity_rea1.59727005
42MP0001800_abnormal_humoral_immune1.59074526
43MP0003950_abnormal_plasma_membrane1.58485870
44MP0010030_abnormal_orbit_morphology1.56831226
45MP0003566_abnormal_cell_adhesion1.56430400
46MP0003763_abnormal_thymus_physiology1.52203351
47MP0002933_joint_inflammation1.52179467
48MP0002420_abnormal_adaptive_immunity1.48026961
49MP0002452_abnormal_antigen_presenting1.47762436
50MP0002127_abnormal_cardiovascular_syste1.45218175
51MP0001819_abnormal_immune_cell1.44367139
52MP0002723_abnormal_immune_serum1.43908310
53MP0003191_abnormal_cellular_cholesterol1.42699612
54MP0002166_altered_tumor_susceptibility1.40755483
55MP0005000_abnormal_immune_tolerance1.39606709
56MP0001853_heart_inflammation1.36537302
57MP0002419_abnormal_innate_immunity1.35116028
58MP0000716_abnormal_immune_system1.34872532
59MP0005387_immune_system_phenotype1.34245424
60MP0001790_abnormal_immune_system1.34245424
61MP0001614_abnormal_blood_vessel1.33015421
62MP0002429_abnormal_blood_cell1.31527604
63MP0009333_abnormal_splenocyte_physiolog1.31149052
64MP0005623_abnormal_meninges_morphology1.28321231
65MP0002132_abnormal_respiratory_system1.25264470
66MP0004782_abnormal_surfactant_physiolog1.24482411
67MP0004233_abnormal_muscle_weight1.23552842
68MP0002095_abnormal_skin_pigmentation1.22210842
69MP0004145_abnormal_muscle_electrophysio1.18910934
70MP0000703_abnormal_thymus_morphology1.17613774
71MP0004510_myositis1.15608895
72MP0002925_abnormal_cardiovascular_devel1.12528992
73MP0002168_other_aberrant_phenotype1.07248161
74MP0005165_increased_susceptibility_to1.07092260
75MP0003656_abnormal_erythrocyte_physiolo1.06403252
76MP0000613_abnormal_salivary_gland1.05675297
77MP0000343_altered_response_to1.03519999
78MP0003075_altered_response_to1.02811879
79MP0003385_abnormal_body_wall1.02513361
80MP0008961_abnormal_basal_metabolism1.02143596
81MP0001845_abnormal_inflammatory_respons1.01816096
82MP0004036_abnormal_muscle_relaxation1.00199886
83MP0000681_abnormal_thyroid_gland1.00107637
84MP0000371_diluted_coat_color1.00081961
85MP0003567_abnormal_fetal_cardiomyocyte0.99668330
86MP0006276_abnormal_autonomic_nervous0.99586399
87MP0001986_abnormal_taste_sensitivity0.99109685
88MP0008004_abnormal_stomach_pH0.98498252
89MP0003091_abnormal_cell_migration0.97539252
90MP0004215_abnormal_myocardial_fiber0.96290554
91MP0005360_urolithiasis0.96124647
92MP0009764_decreased_sensitivity_to0.95464128
93MP0000477_abnormal_intestine_morphology0.95286836
94MP0003868_abnormal_feces_composition0.93392759
95MP0001533_abnormal_skeleton_physiology0.93293081
96MP0000049_abnormal_middle_ear0.92591328
97MP0008469_abnormal_protein_level0.92272926
98MP0002128_abnormal_blood_circulation0.92199898
99MP0001873_stomach_inflammation0.92175107
100MP0002295_abnormal_pulmonary_circulatio0.90737862
101MP0003045_fibrosis0.90613136
102MP0008775_abnormal_heart_ventricle0.89581973
103MP0001293_anophthalmia0.87905172
104MP0005166_decreased_susceptibility_to0.87514396
105MP0002332_abnormal_exercise_endurance0.87317136
106MP0010352_gastrointestinal_tract_polyps0.86529174
107MP0001784_abnormal_fluid_regulation0.86521487
108MP0002877_abnormal_melanocyte_morpholog0.86011161
109MP0002075_abnormal_coat/hair_pigmentati0.85258636
110MP0004947_skin_inflammation0.83872181
111MP0001851_eye_inflammation0.83862788
112MP0003011_delayed_dark_adaptation0.83516776
113MP0003279_aneurysm0.83015912
114MP0001849_ear_inflammation0.81000013
115MP0005395_other_phenotype0.80677595
116MP0002160_abnormal_reproductive_system0.79226680
117MP0002006_tumorigenesis0.79065047
118MP0000013_abnormal_adipose_tissue0.79043232
119MP0004085_abnormal_heartbeat0.78709906
120MP0000747_muscle_weakness0.77197210
121MP0009763_increased_sensitivity_to0.77050168
122MP0001188_hyperpigmentation0.76650979
123MP0000230_abnormal_systemic_arterial0.76382494
124MP0001544_abnormal_cardiovascular_syste0.76307843
125MP0005385_cardiovascular_system_phenoty0.76307843
126MP0002405_respiratory_system_inflammati0.75900602
127MP0001664_abnormal_digestion0.75694422
128MP0000767_abnormal_smooth_muscle0.73276347
129MP0005409_darkened_coat_color0.71734328
130MP0000598_abnormal_liver_morphology0.71221821
131MP0010630_abnormal_cardiac_muscle0.70835967
132MP0003638_abnormal_response/metabolism_0.70252645
133MP0000470_abnormal_stomach_morphology0.68739847
134MP0002928_abnormal_bile_duct0.68587115
135MP0000858_altered_metastatic_potential0.68247072
136MP0002932_abnormal_joint_morphology0.67593830
137MP0001958_emphysema0.67064264
138MP0009765_abnormal_xenobiotic_induced0.66802283
139MP0001663_abnormal_digestive_system0.66294844
140MP0000266_abnormal_heart_morphology0.65777547
141MP0000249_abnormal_blood_vessel0.65448824
142MP0002089_abnormal_postnatal_growth/wei0.64871783
143MP0002009_preneoplasia0.64810681
144MP0001348_abnormal_lacrimal_gland0.64809627
145MP0005220_abnormal_exocrine_pancreas0.63786173
146MP0001915_intracranial_hemorrhage0.63359338
147MP0003941_abnormal_skin_development0.61209182
148MP0009931_abnormal_skin_appearance0.60953036
149MP0004133_heterotaxia0.60095272
150MP0006138_congestive_heart_failure0.60062055
151MP0003935_abnormal_craniofacial_develop0.57657264
152MP0005023_abnormal_wound_healing0.56656703
153MP0002092_abnormal_eye_morphology0.55467518
154MP0003984_embryonic_growth_retardation0.52632935
155MP0002972_abnormal_cardiac_muscle0.50908863
156MP0002088_abnormal_embryonic_growth/wei0.50435502
157MP0000467_abnormal_esophagus_morphology0.50375709
158MP0004883_abnormal_blood_vessel0.48853804
159MP0002086_abnormal_extraembryonic_tissu0.48357468
160MP0002177_abnormal_outer_ear0.47358571
161MP0005197_abnormal_uvea_morphology0.46216013
162MP0005388_respiratory_system_phenotype0.45546218
163MP0002133_abnormal_respiratory_system0.45546218
164MP0003705_abnormal_hypodermis_morpholog0.44553463
165MP0001191_abnormal_skin_condition0.43975281

Predicted human phenotypes

RankGene SetZ-score
1Conjunctival telangiectasia (HP:0000524)6.17484007
2Visual hallucinations (HP:0002367)5.80335183
3Distal arthrogryposis (HP:0005684)5.74167531
4Abnormality of the vasculature of the conjunctiva (HP:0008054)5.51667769
5Prolonged bleeding time (HP:0003010)5.35001767
6Thrombocytosis (HP:0001894)5.30191024
7Peripheral hypomyelination (HP:0007182)5.29299509
8Ankle contracture (HP:0006466)5.16211355
9Stenosis of the external auditory canal (HP:0000402)5.12157949
10Esophageal varix (HP:0002040)4.96438370
11Amyotrophic lateral sclerosis (HP:0007354)4.93278826
12Cerebral hemorrhage (HP:0001342)4.76976440
13Axonal loss (HP:0003447)4.76351479
14Abnormality of the intrinsic pathway (HP:0010989)4.57723930
15Abnormality of the distal phalanges of the toes (HP:0010182)4.45302648
16Abnormality of the heme biosynthetic pathway (HP:0010472)4.40462383
17Wrist flexion contracture (HP:0001239)4.38705223
18Joint hemorrhage (HP:0005261)4.34460097
19Syringomyelia (HP:0003396)4.24299904
20Spinal cord lesions (HP:0100561)4.24299904
21Decreased skull ossification (HP:0004331)4.23738506
22Skull defect (HP:0001362)4.08486372
23Epistaxis (HP:0000421)3.97200687
24Aplastic anemia (HP:0001915)3.90506546
25Broad alveolar ridges (HP:0000187)3.88645424
26Abnormality of skull ossification (HP:0002703)3.80496900
27Adactyly (HP:0009776)3.72619461
28Spondylolisthesis (HP:0003302)3.66871011
29Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.66756930
30Spontaneous hematomas (HP:0007420)3.58855190
31Arterial tortuosity (HP:0005116)3.56541120
32Abnormality of cells of the erythroid lineage (HP:0012130)3.54297301
33IgM deficiency (HP:0002850)3.51488105
34Mucosal telangiectasiae (HP:0100579)3.50361730
35Fatigue (HP:0012378)3.49448196
36Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.48648281
37Abnormal number of erythroid precursors (HP:0012131)3.41276962
38Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.39055481
39Short 4th metacarpal (HP:0010044)3.39055481
40Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.37242794
41Gingival bleeding (HP:0000225)3.33109212
42Protrusio acetabuli (HP:0003179)3.32524803
43Petechiae (HP:0000967)3.26759627
44Glossoptosis (HP:0000162)3.25593518
45Purpura (HP:0000979)3.15526244
46Aplasia/Hypoplasia of the sternum (HP:0006714)3.12723308
47Premature loss of primary teeth (HP:0006323)3.10873728
48Pigmentary retinal degeneration (HP:0001146)3.10195685
49Abnormal platelet function (HP:0011869)3.05878309
50Impaired platelet aggregation (HP:0003540)3.05878309
51Frequent falls (HP:0002359)3.05834176
52Abnormality of the frontal sinuses (HP:0002687)3.03967120
53Vascular tortuosity (HP:0004948)3.03951761
54Atrophy/Degeneration involving motor neurons (HP:0007373)3.03792066
55Absent frontal sinuses (HP:0002688)2.96449906
56Abnormality of the 4th metacarpal (HP:0010012)2.95008589
57Visceral angiomatosis (HP:0100761)2.94689997
58Abnormality of the nasal mucosa (HP:0000433)2.94625808
59Amaurosis fugax (HP:0100576)2.92451076
60Myotonia (HP:0002486)2.92424701
61Myositis (HP:0100614)2.91048255
62Absent thumb (HP:0009777)2.88856566
63Myelodysplasia (HP:0002863)2.86807397
64Arterial thrombosis (HP:0004420)2.84482213
65Hemangiomatosis (HP:0007461)2.84213786
66Overgrowth (HP:0001548)2.83090189
67Microcytic anemia (HP:0001935)2.79512833
68Aortic aneurysm (HP:0004942)2.75532102
69Sparse scalp hair (HP:0002209)2.75323908
70Spontaneous abortion (HP:0005268)2.71114672
71Reticulocytopenia (HP:0001896)2.64998992
72Vertebral clefting (HP:0008428)2.63850784
73Tetraparesis (HP:0002273)2.58428887
74Spinal rigidity (HP:0003306)2.57450228
75Abnormality of the alveolar ridges (HP:0006477)2.54978179
76Asplenia (HP:0001746)2.54020784
77Abnormal vertebral ossification (HP:0100569)2.53889884
78Sparse eyelashes (HP:0000653)2.53359049
79Subcapsular cataract (HP:0000523)2.48269636
80Nonprogressive disorder (HP:0003680)2.47511671
81Pallor (HP:0000980)2.47373581
82Aortic valve stenosis (HP:0001650)2.43968774
83Cellulitis (HP:0100658)2.43900620
84Abnormal platelet volume (HP:0011876)2.42401428
85Severe global developmental delay (HP:0011344)2.41465506
86Cavernous hemangioma (HP:0001048)2.39520736
87Chest pain (HP:0100749)2.37951914
88Orchitis (HP:0100796)2.35529144
89Beaking of vertebral bodies (HP:0004568)2.35119048
90Neonatal death (HP:0003811)2.34996497
91Acute myeloid leukemia (HP:0004808)2.34823679
92Menorrhagia (HP:0000132)2.34366419
93Aplasia/Hypoplasia of the hallux (HP:0008362)2.33761606
94Pulmonary hypertension (HP:0002092)2.33230520
95Cervical subluxation (HP:0003308)2.31704581
96Bruising susceptibility (HP:0000978)2.29172655
97Aplasia/Hypoplasia of the spleen (HP:0010451)2.24114594
98Vacuolated lymphocytes (HP:0001922)2.22611806
99Lymphangioma (HP:0100764)2.20479013
100High pitched voice (HP:0001620)2.20064469
101Gonadotropin excess (HP:0000837)2.19228559
102Type 2 muscle fiber atrophy (HP:0003554)2.18988319
103Short clavicles (HP:0000894)2.17989812
104Mitral valve prolapse (HP:0001634)2.17693010
105Stroke (HP:0001297)2.16934815
106Hip contracture (HP:0003273)2.16717748
107Joint contractures involving the joints of the feet (HP:0100492)2.15441877
108Flexion contracture of toe (HP:0005830)2.15441877
109Bifid uvula (HP:0000193)2.15240038
110Porencephaly (HP:0002132)2.14907167
111Weak cry (HP:0001612)2.11235974
112Fused cervical vertebrae (HP:0002949)2.09593549
113Tinnitus (HP:0000360)2.08077769
114Abnormality of T cell physiology (HP:0011840)2.06195653
115Muscle fiber atrophy (HP:0100295)2.05395580
116Aortic dissection (HP:0002647)2.03743066
117Capillary hemangiomas (HP:0005306)2.00126643
118Pulmonary embolism (HP:0002204)2.00001766
119Recurrent bronchitis (HP:0002837)1.99449397
120Occipital encephalocele (HP:0002085)1.99236883
121Increased mean platelet volume (HP:0011877)1.97333942
122Thrombophlebitis (HP:0004418)1.96126831
123Elevated erythrocyte sedimentation rate (HP:0003565)1.95676401
124Congenital, generalized hypertrichosis (HP:0004540)1.91976492
125Coxa valga (HP:0002673)1.91716459
126Tapered finger (HP:0001182)1.89994204
127Posterior subcapsular cataract (HP:0007787)1.88666944
128Optic neuritis (HP:0100653)1.87217217
129Retrobulbar optic neuritis (HP:0100654)1.87217217
130Portal hypertension (HP:0001409)1.87164210
131Volvulus (HP:0002580)1.86332044
132Disproportionate short-trunk short stature (HP:0003521)1.86034473
133Migraine (HP:0002076)1.85882995
134Aplasia/Hypoplasia of the clavicles (HP:0006710)1.85458832
135Hematochezia (HP:0002573)1.85252937
136Vertigo (HP:0002321)1.83379833
137Erythema (HP:0010783)1.83055469
138Cerebral aneurysm (HP:0004944)1.82583383
139Absent hand (HP:0004050)1.82167466
140Vertebral compression fractures (HP:0002953)1.80465356
141Interstitial pulmonary disease (HP:0006530)1.80147367
142Hemorrhage of the eye (HP:0011885)1.80075921
143Striae distensae (HP:0001065)1.80073386
144Annular pancreas (HP:0001734)1.79173925
145Neoplasm of the oral cavity (HP:0100649)1.79111591
146Hypochromic anemia (HP:0001931)1.78155357
147Periodontitis (HP:0000704)1.78057613
148Flat face (HP:0012368)1.75472729
149Abnormality of the phalanges of the 2nd finger (HP:0009541)1.74809875
150Abnormality of the hepatic vasculature (HP:0006707)1.74609985
151Flat acetabular roof (HP:0003180)1.74292674
152Broad face (HP:0000283)1.74221000
153Nasal polyposis (HP:0100582)1.72332863
154Polycythemia (HP:0001901)1.72124147
155Reduced antithrombin III activity (HP:0001976)1.71961335
156Gastrointestinal stroma tumor (HP:0100723)1.71438765
157Hyperlipoproteinemia (HP:0010980)1.70163182
158Orthostatic hypotension (HP:0001278)1.68940908
159Difficulty climbing stairs (HP:0003551)1.68221407
160Venous insufficiency (HP:0005293)1.68000992
161Bulbous nose (HP:0000414)1.65799535
162Thoracolumbar scoliosis (HP:0002944)1.62716588
163Congenital hepatic fibrosis (HP:0002612)1.62065674
164Abnormality of the right ventricle (HP:0001707)1.60134530
165Teleangiectasia of the skin (HP:0100585)1.57547612
166Nonimmune hydrops fetalis (HP:0001790)1.56470212
167Vertebral hypoplasia (HP:0008417)1.55095498
168Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.55095498
169Congenital hip dislocation (HP:0001374)1.54005905
170Limited hip movement (HP:0008800)1.52491225
171Scotoma (HP:0000575)1.51832863
172Full cheeks (HP:0000293)1.51020683
173Abnormality of the acetabulum (HP:0003170)1.50527258
174Intestinal polyposis (HP:0200008)1.50369238
175Cerebral ischemia (HP:0002637)1.50030255
176Incomplete penetrance (HP:0003829)1.49997665
177Fibular aplasia (HP:0002990)1.49690021
178Hemoptysis (HP:0002105)1.48428069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG6.76266057
2TIE15.56817652
3TGFBR13.50789013
4TGFBR22.95477006
5MUSK2.94956073
6KDR2.80644986
7IKBKE2.57678953
8FER2.53052802
9JAK32.17337438
10RPS6KA42.10532140
11MAP4K12.10446124
12KIT2.06141453
13MAP2K31.99054869
14ADRBK21.90954506
15EEF2K1.85434622
16ERN11.84742876
17BTK1.83790693
18ITK1.83372412
19MATK1.76353687
20EPHB21.71609268
21PTK2B1.69210115
22MKNK11.61466007
23RPS6KB21.58117651
24IKBKB1.53552074
25TEC1.52999934
26CDK191.52689538
27DYRK31.49023507
28FLT31.45181765
29PTK21.42737010
30ZAP701.42110236
31MAP2K61.35351768
32MAP3K121.32451171
33MYLK1.29949596
34PRKG21.29044272
35PKN21.24070680
36PASK1.21735371
37TBK11.19712846
38TXK1.18775436
39NME21.16910128
40SYK1.15636427
41CDK81.08059555
42MAPKAPK51.03392711
43CSK0.99446976
44CAMKK20.97136934
45VRK10.95082492
46NTRK10.91190096
47TRPM70.90103243
48CDC70.89647309
49BLK0.88557445
50GRK10.83770439
51FGFR30.81411695
52PIK3CA0.80393439
53LYN0.80288007
54TNK20.79832856
55EIF2AK30.79712871
56HIPK20.77806373
57MAPKAPK30.75943539
58MAP3K130.73572965
59CCNB10.72997388
60STK240.70597467
61DAPK10.69564394
62CHUK0.69440715
63BCKDK0.68769071
64NUAK10.67762280
65RPS6KA60.67012632
66TTN0.66001685
67LRRK20.65912858
68MAPK40.63455101
69MKNK20.62834467
70PIM10.62817040
71RPS6KA50.61102498
72FES0.60483265
73LCK0.59089349
74STK160.57151657
75FRK0.57065091
76BMPR1B0.56698203
77CSF1R0.56220248
78WEE10.55645917
79PLK20.55351022
80CDK60.54889945
81GRK50.50616687
82CAMK10.48835502
83CAMK40.48793286
84EPHA30.47757733
85HCK0.47519197
86TAOK30.46096368
87MAPK110.45456018
88PAK40.44444175
89IRAK40.43848166
90CLK10.43649866
91IGF1R0.42092059
92TNIK0.41958821
93NLK0.40999046
94EGFR0.39234179
95RPS6KC10.38792939
96RPS6KL10.38792939
97MET0.37832490
98PRKCE0.37510987
99INSR0.37361275
100ACVR1B0.36925660
101PDGFRB0.36696905
102SGK20.35781410
103MAPK120.35522095
104SRC0.34688021
105ERBB30.34240167
106MAPK30.33692678
107ATR0.32043681
108FGFR20.31419073
109RPS6KA20.31375369
110DAPK30.31340862
111PRKAA20.30162971
112PAK60.30039178
113IRAK30.29936855
114ZAK0.29280837
115CDK90.28157572
116BMX0.27956187
117EPHB10.27932491
118JAK20.27840540
119IRAK10.27699231
120JAK10.27214761
121YES10.26603226
122PTK60.26240770
123TYK20.25917770
124CSNK1G30.25861566
125CSNK1G10.24500942
126ROCK10.23805661
127ROCK20.22727407
128AURKB0.21984394
129ABL10.21079137
130MAP4K20.20775572
131PRKD10.20050232
132CDK70.19670017
133FYN0.19495946
134STK30.19415555
135MOS0.18990370
136CAMK1D0.18928078
137BRSK20.18679222
138NTRK20.18544968
139ILK0.18018901
140MAP3K60.17798972
141PRKG10.17639581
142PDGFRA0.17507758
143PDK10.17462655
144ADRBK10.16147590
145STK40.15874831
146DAPK20.15779722
147PAK20.15107030
148FGR0.13833640
149MAP2K40.13515973
150SGK30.12974534
151MAP3K110.11229404
152RET0.10851664
153STK100.10805758
154PINK10.10507352

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.74956189
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.46279646
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.42611824
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.35143662
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.63381600
6Platelet activation_Homo sapiens_hsa046112.58753138
7DNA replication_Homo sapiens_hsa030302.25718250
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.23094575
9Mismatch repair_Homo sapiens_hsa034302.17144660
10Transcriptional misregulation in cancer_Homo sapiens_hsa052022.08184170
11B cell receptor signaling pathway_Homo sapiens_hsa046622.04102520
12Vascular smooth muscle contraction_Homo sapiens_hsa042701.97209434
13Measles_Homo sapiens_hsa051621.96804773
14Complement and coagulation cascades_Homo sapiens_hsa046101.92132183
15Base excision repair_Homo sapiens_hsa034101.80887089
16Leishmaniasis_Homo sapiens_hsa051401.73410086
17Serotonergic synapse_Homo sapiens_hsa047261.73023373
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.65361900
19TGF-beta signaling pathway_Homo sapiens_hsa043501.61649978
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.60324770
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.57936407
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53432468
23Acute myeloid leukemia_Homo sapiens_hsa052211.52762348
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.52738135
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.52635881
26Pyrimidine metabolism_Homo sapiens_hsa002401.51821017
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.48763992
28Adherens junction_Homo sapiens_hsa045201.47338692
29Osteoclast differentiation_Homo sapiens_hsa043801.45251313
30Gap junction_Homo sapiens_hsa045401.44347693
31Hepatitis B_Homo sapiens_hsa051611.43466662
32Malaria_Homo sapiens_hsa051441.43428192
33Hedgehog signaling pathway_Homo sapiens_hsa043401.39833435
34Chronic myeloid leukemia_Homo sapiens_hsa052201.37955694
35Legionellosis_Homo sapiens_hsa051341.36245468
36Influenza A_Homo sapiens_hsa051641.31868408
37Sulfur metabolism_Homo sapiens_hsa009201.31808014
38Herpes simplex infection_Homo sapiens_hsa051681.31452028
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30766431
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.29805100
41Primary immunodeficiency_Homo sapiens_hsa053401.28045332
42Other glycan degradation_Homo sapiens_hsa005111.24004479
43Hematopoietic cell lineage_Homo sapiens_hsa046401.23247690
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21188333
45Basal cell carcinoma_Homo sapiens_hsa052171.20184921
46Renin secretion_Homo sapiens_hsa049241.20146561
47Toxoplasmosis_Homo sapiens_hsa051451.18218739
48Prolactin signaling pathway_Homo sapiens_hsa049171.17141041
49TNF signaling pathway_Homo sapiens_hsa046681.16676210
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16174376
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.12808360
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11905236
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.11450959
54Long-term depression_Homo sapiens_hsa047301.09121401
55Renin-angiotensin system_Homo sapiens_hsa046141.08849308
56Ras signaling pathway_Homo sapiens_hsa040141.08469321
57Pertussis_Homo sapiens_hsa051331.07903232
58Shigellosis_Homo sapiens_hsa051311.05980400
59Proteoglycans in cancer_Homo sapiens_hsa052051.05512309
60Purine metabolism_Homo sapiens_hsa002301.04953544
61Linoleic acid metabolism_Homo sapiens_hsa005911.04891172
62RNA degradation_Homo sapiens_hsa030181.04140252
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03085411
64Caffeine metabolism_Homo sapiens_hsa002321.02925996
65Olfactory transduction_Homo sapiens_hsa047401.02531493
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01846593
67Dilated cardiomyopathy_Homo sapiens_hsa054141.01150808
68African trypanosomiasis_Homo sapiens_hsa051430.99110729
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96942597
70Antigen processing and presentation_Homo sapiens_hsa046120.96517039
71Axon guidance_Homo sapiens_hsa043600.96106138
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96031904
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96024595
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95659221
75Homologous recombination_Homo sapiens_hsa034400.95304996
76Small cell lung cancer_Homo sapiens_hsa052220.94747228
77Non-small cell lung cancer_Homo sapiens_hsa052230.92393441
78Alcoholism_Homo sapiens_hsa050340.89114648
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.88939522
80RNA polymerase_Homo sapiens_hsa030200.87343732
81Ether lipid metabolism_Homo sapiens_hsa005650.86820859
82Spliceosome_Homo sapiens_hsa030400.85629772
83Salmonella infection_Homo sapiens_hsa051320.83643471
84Systemic lupus erythematosus_Homo sapiens_hsa053220.82523603
85Salivary secretion_Homo sapiens_hsa049700.82400183
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81176238
87Circadian entrainment_Homo sapiens_hsa047130.81068408
88Nucleotide excision repair_Homo sapiens_hsa034200.80932796
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80783586
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79871165
91HIF-1 signaling pathway_Homo sapiens_hsa040660.79232567
92Glutamatergic synapse_Homo sapiens_hsa047240.75888920
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74184023
94Pancreatic secretion_Homo sapiens_hsa049720.73926531
95Melanogenesis_Homo sapiens_hsa049160.73898670
96Taste transduction_Homo sapiens_hsa047420.73259929
97Hippo signaling pathway_Homo sapiens_hsa043900.72350874
98VEGF signaling pathway_Homo sapiens_hsa043700.72289758
99Apoptosis_Homo sapiens_hsa042100.71999542
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70765484
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.69844775
102Hepatitis C_Homo sapiens_hsa051600.69223340
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68875764
104Morphine addiction_Homo sapiens_hsa050320.67704327
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67157495
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64163067
107Tight junction_Homo sapiens_hsa045300.63914899
108cAMP signaling pathway_Homo sapiens_hsa040240.62164719
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61563064
110Oxytocin signaling pathway_Homo sapiens_hsa049210.60676977
111Cell cycle_Homo sapiens_hsa041100.60085178
112Ovarian steroidogenesis_Homo sapiens_hsa049130.60034130
113Pancreatic cancer_Homo sapiens_hsa052120.59953272
114Thyroid hormone synthesis_Homo sapiens_hsa049180.58564338
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58479344
116Inositol phosphate metabolism_Homo sapiens_hsa005620.57874056
117Non-homologous end-joining_Homo sapiens_hsa034500.56977082
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56921866
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56580480
120Phagosome_Homo sapiens_hsa041450.56488028
121Chemokine signaling pathway_Homo sapiens_hsa040620.55998369
122Selenocompound metabolism_Homo sapiens_hsa004500.55816171
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53648252
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52925203
125Endocytosis_Homo sapiens_hsa041440.52170232
126Galactose metabolism_Homo sapiens_hsa000520.50498588
127Rap1 signaling pathway_Homo sapiens_hsa040150.49964505
128GnRH signaling pathway_Homo sapiens_hsa049120.49796869
129Arachidonic acid metabolism_Homo sapiens_hsa005900.48540216
130HTLV-I infection_Homo sapiens_hsa051660.48147388
131Folate biosynthesis_Homo sapiens_hsa007900.46540929
132Notch signaling pathway_Homo sapiens_hsa043300.46069304
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.45123237
134Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45043567
135Epstein-Barr virus infection_Homo sapiens_hsa051690.44785484
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43605686
137Bladder cancer_Homo sapiens_hsa052190.43093749
138Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42958620
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.41850262
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40625408
141Choline metabolism in cancer_Homo sapiens_hsa052310.40410823
142Dorso-ventral axis formation_Homo sapiens_hsa043200.40293375
143Rheumatoid arthritis_Homo sapiens_hsa053230.40093276
144MAPK signaling pathway_Homo sapiens_hsa040100.39970665
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39787562
146Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39150286
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38874769
148Amoebiasis_Homo sapiens_hsa051460.38805086
149Focal adhesion_Homo sapiens_hsa045100.38769808
150Pathways in cancer_Homo sapiens_hsa052000.37887695
151Colorectal cancer_Homo sapiens_hsa052100.37124926
152Cholinergic synapse_Homo sapiens_hsa047250.36996471
153ECM-receptor interaction_Homo sapiens_hsa045120.35756264
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.35661566
155Insulin resistance_Homo sapiens_hsa049310.35641816
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.35394872
157p53 signaling pathway_Homo sapiens_hsa041150.35138628
158RNA transport_Homo sapiens_hsa030130.35097522
159Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31478492
160ABC transporters_Homo sapiens_hsa020100.30965377
161T cell receptor signaling pathway_Homo sapiens_hsa046600.30632557
162N-Glycan biosynthesis_Homo sapiens_hsa005100.29469725
163Viral carcinogenesis_Homo sapiens_hsa052030.29434042

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