MMS22L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene forms a complex with tonsoku-like, DNA repair protein (TONSL), and this complex recognizes and repairs DNA double-strand breaks at sites of stalled or collapsed replication forks. The encoded protein also can bind with the histone-associated protein NFKBIL2 to help regulate the chromatin state at stalled replication forks. Finally, this gene appears to be overexpressed in most lung and esophageal cancers. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.27445525
2DNA double-strand break processing (GO:0000729)5.20683625
3DNA replication initiation (GO:0006270)5.09208450
4DNA strand elongation involved in DNA replication (GO:0006271)5.07396168
5protein localization to kinetochore (GO:0034501)4.94830133
6DNA strand elongation (GO:0022616)4.83888741
7DNA replication checkpoint (GO:0000076)4.75993140
8telomere maintenance via semi-conservative replication (GO:0032201)4.71401379
9negative regulation of DNA-dependent DNA replication (GO:2000104)4.67869253
10regulation of DNA endoreduplication (GO:0032875)4.51203684
11DNA replication-dependent nucleosome assembly (GO:0006335)4.49683784
12DNA replication-dependent nucleosome organization (GO:0034723)4.49683784
13mitotic metaphase plate congression (GO:0007080)4.36898946
14nuclear pore organization (GO:0006999)4.36619027
15protein localization to chromosome, centromeric region (GO:0071459)4.36205298
16telomere maintenance via recombination (GO:0000722)4.34873815
17mitotic chromosome condensation (GO:0007076)4.31488559
18mitotic recombination (GO:0006312)4.29354403
19kinetochore organization (GO:0051383)4.28242472
20nuclear pore complex assembly (GO:0051292)4.27366235
21chromatin remodeling at centromere (GO:0031055)4.22388209
22CENP-A containing nucleosome assembly (GO:0034080)4.21473389
23* replication fork processing (GO:0031297)4.21073963
24DNA replication-independent nucleosome assembly (GO:0006336)4.04027522
25DNA replication-independent nucleosome organization (GO:0034724)4.04027522
26centriole replication (GO:0007099)4.01643389
27mitotic nuclear envelope disassembly (GO:0007077)4.01314324
28mitotic sister chromatid segregation (GO:0000070)4.00526399
29regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.95418393
30metaphase plate congression (GO:0051310)3.95096562
31sister chromatid segregation (GO:0000819)3.85619462
32telomere maintenance via telomere lengthening (GO:0010833)3.85349470
33nucleobase biosynthetic process (GO:0046112)3.85095738
34synapsis (GO:0007129)3.82910641
35mitotic sister chromatid cohesion (GO:0007064)3.80910250
36attachment of spindle microtubules to kinetochore (GO:0008608)3.80381614
37kinetochore assembly (GO:0051382)3.76619313
38membrane disassembly (GO:0030397)3.72645707
39nuclear envelope disassembly (GO:0051081)3.72645707
40nucleotide-excision repair, DNA gap filling (GO:0006297)3.71573543
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.71541772
42folic acid-containing compound biosynthetic process (GO:0009396)3.71111381
43* double-strand break repair via homologous recombination (GO:0000724)3.69400587
44* recombinational repair (GO:0000725)3.68958609
45meiotic chromosome segregation (GO:0045132)3.68226412
46DNA geometric change (GO:0032392)3.60174670
47DNA duplex unwinding (GO:0032508)3.59467011
48establishment of chromosome localization (GO:0051303)3.57286656
49histone exchange (GO:0043486)3.56941810
50purine nucleobase biosynthetic process (GO:0009113)3.54708620
51chromatin assembly or disassembly (GO:0006333)3.53678145
52IMP biosynthetic process (GO:0006188)3.52288390
53regulation of mitotic spindle checkpoint (GO:1903504)3.50474761
54regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.50474761
55regulation of spindle organization (GO:0090224)3.50139124
56protein K6-linked ubiquitination (GO:0085020)3.49836973
57regulation of histone H3-K9 methylation (GO:0051570)3.46325710
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.45378234
59ribosomal small subunit assembly (GO:0000028)3.37737483
60DNA strand renaturation (GO:0000733)3.37513939
61regulation of centrosome duplication (GO:0010824)3.36648776
62centrosome organization (GO:0051297)3.36548116
63positive regulation of chromosome segregation (GO:0051984)3.33683383
64resolution of meiotic recombination intermediates (GO:0000712)3.33189244
65protein localization to chromosome (GO:0034502)3.32426075
66pore complex assembly (GO:0046931)3.32149995
67negative regulation of translation, ncRNA-mediated (GO:0040033)3.29203757
68regulation of translation, ncRNA-mediated (GO:0045974)3.29203757
69negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.29203757
70regulation of chromosome segregation (GO:0051983)3.28369326
71DNA catabolic process, exonucleolytic (GO:0000738)3.25860995
72regulation of double-strand break repair via homologous recombination (GO:0010569)3.25599775
73translesion synthesis (GO:0019985)3.25078763
74formation of translation preinitiation complex (GO:0001731)3.24828651
75maturation of SSU-rRNA (GO:0030490)3.24713511
76spindle checkpoint (GO:0031577)3.22646168
77telomere maintenance (GO:0000723)3.22631095
78regulation of sister chromatid cohesion (GO:0007063)3.21535025
79telomere organization (GO:0032200)3.21238061
80somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20647568
81somatic hypermutation of immunoglobulin genes (GO:0016446)3.20647568
82mismatch repair (GO:0006298)3.20058006
83microtubule organizing center organization (GO:0031023)3.19637691
84RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.18906826
85negative regulation of chromosome segregation (GO:0051985)3.18799624
86sister chromatid cohesion (GO:0007062)3.16796189
87negative regulation of DNA recombination (GO:0045910)3.16712943
88spindle assembly checkpoint (GO:0071173)3.15255886
89regulation of centrosome cycle (GO:0046605)3.15246738
90negative regulation of mitotic sister chromatid separation (GO:2000816)3.13615662
91negative regulation of mitotic sister chromatid segregation (GO:0033048)3.13615662
92negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.13615662
93negative regulation of sister chromatid segregation (GO:0033046)3.13615662
94DNA conformation change (GO:0071103)3.13494940
95IMP metabolic process (GO:0046040)3.13217365
96ATP-dependent chromatin remodeling (GO:0043044)3.13055946
97regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12927596
98negative regulation of histone methylation (GO:0031061)3.12735010
99regulation of nuclear cell cycle DNA replication (GO:0033262)3.12668842
100chromosome segregation (GO:0007059)3.12107325
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.08514784
102negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07884726
103reciprocal DNA recombination (GO:0035825)3.07565745
104reciprocal meiotic recombination (GO:0007131)3.07565745
105ribosome assembly (GO:0042255)3.07167608
106microtubule depolymerization (GO:0007019)3.06651444
107mitotic spindle assembly checkpoint (GO:0007094)3.06497463
108dosage compensation (GO:0007549)3.06310629
109mitotic G2/M transition checkpoint (GO:0044818)3.05847642
110regulation of centriole replication (GO:0046599)3.05595785
111non-recombinational repair (GO:0000726)3.05204608
112double-strand break repair via nonhomologous end joining (GO:0006303)3.05204608
113mitotic spindle checkpoint (GO:0071174)3.00099360
114regulation of mitotic spindle organization (GO:0060236)2.99339424
115centrosome duplication (GO:0051298)2.98680738
116regulation of helicase activity (GO:0051095)2.98639128
117regulation of sister chromatid segregation (GO:0033045)2.97652807
118regulation of mitotic sister chromatid separation (GO:0010965)2.97652807
119regulation of mitotic sister chromatid segregation (GO:0033047)2.97652807
120positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.96598660
121positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.96598660
122positive regulation of mitotic sister chromatid separation (GO:1901970)2.96598660
123response to X-ray (GO:0010165)2.95878888
124ribosome biogenesis (GO:0042254)2.94959027
125* maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.94660564
126* double-strand break repair (GO:0006302)2.93543219
127DNA topological change (GO:0006265)2.93253291
128microtubule polymerization or depolymerization (GO:0031109)2.92474696
129postreplication repair (GO:0006301)2.92469795
130negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92082949
131DNA deamination (GO:0045006)2.90289432
132chromosome condensation (GO:0030261)2.90208759
133* DNA recombination (GO:0006310)2.89935116
134microtubule anchoring (GO:0034453)2.89517247
135somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.88141137
136somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.88141137
137isotype switching (GO:0045190)2.88141137
138negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.83155863
139response to pheromone (GO:0019236)2.79557656
140DNA-dependent DNA replication (GO:0006261)2.79464068
141DNA ligation (GO:0006266)2.79377098
142neural tube formation (GO:0001841)2.78810848
143histone-serine phosphorylation (GO:0035404)2.73083045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.18848697
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.35154731
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.83497050
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.54872176
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16591904
6ZNF274_21170338_ChIP-Seq_K562_Hela2.82618764
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72288491
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59700511
9EWS_26573619_Chip-Seq_HEK293_Human2.53655294
10VDR_22108803_ChIP-Seq_LS180_Human2.50951222
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.40669678
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40445176
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39752842
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.38366694
15FUS_26573619_Chip-Seq_HEK293_Human2.37119610
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35705980
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33833958
18AR_21909140_ChIP-Seq_LNCAP_Human2.31436945
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.24997358
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23104097
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20266238
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18763010
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18732181
24GBX2_23144817_ChIP-Seq_PC3_Human2.15457372
25IGF1R_20145208_ChIP-Seq_DFB_Human2.09196591
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08672899
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06786704
28XRN2_22483619_ChIP-Seq_HELA_Human2.05904892
29ETS1_20019798_ChIP-Seq_JURKAT_Human2.04272734
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03941245
31E2F7_22180533_ChIP-Seq_HELA_Human10.8942906
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99201558
33TAF15_26573619_Chip-Seq_HEK293_Human1.98999874
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.98516610
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95710938
36VDR_23849224_ChIP-Seq_CD4+_Human1.94710186
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92912897
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87445154
39P300_19829295_ChIP-Seq_ESCs_Human1.86423514
40MYC_22102868_ChIP-Seq_BL_Human1.86211043
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.81163399
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81134881
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78330079
44FOXP3_21729870_ChIP-Seq_TREG_Human1.75057327
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70187760
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68228524
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66984049
48IRF1_19129219_ChIP-ChIP_H3396_Human1.64343476
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64077942
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63713677
51DCP1A_22483619_ChIP-Seq_HELA_Human1.61279787
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60519037
53CIITA_25753668_ChIP-Seq_RAJI_Human1.59778021
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56376107
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56180257
56TTF2_22483619_ChIP-Seq_HELA_Human1.55995702
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55782678
58GABP_19822575_ChIP-Seq_HepG2_Human1.55411516
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54198193
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53214086
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52265857
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.50096374
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46478643
64ELK1_19687146_ChIP-ChIP_HELA_Human1.45580647
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45092202
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44675202
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43992059
68ER_23166858_ChIP-Seq_MCF-7_Human1.43859988
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43755819
70KDM5A_27292631_Chip-Seq_BREAST_Human1.42057962
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42019702
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41717848
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39633287
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38365702
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37443744
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36501173
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33383112
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32271687
79STAT3_23295773_ChIP-Seq_U87_Human1.31959755
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30695978
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28150013
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26919062
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24000524
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.23496324
85VDR_21846776_ChIP-Seq_THP-1_Human1.23411088
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23280333
87SMAD4_21799915_ChIP-Seq_A2780_Human1.22879426
88BCAT_22108803_ChIP-Seq_LS180_Human1.21708258
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21088075
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20929307
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20621372
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.17413022
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17310476
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17242779
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17242779
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17195231
97CBP_20019798_ChIP-Seq_JUKART_Human1.17195231
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16633646
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16555603
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16134247
101TCF4_23295773_ChIP-Seq_U87_Human1.15431200
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14944435
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14866265
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.14624569
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13916315
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13885875
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.12622826
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11168207
109TFEB_21752829_ChIP-Seq_HELA_Human1.10855021
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10801794
111YY1_21170310_ChIP-Seq_MESCs_Mouse1.10541473
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10164484
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09854865
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09757805
115SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09175387
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.08981412
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08760763
118AR_25329375_ChIP-Seq_VCAP_Human1.08374411
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07743204
120PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05684853
121FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05620514
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04578694
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04571235
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03940220
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03805145
126TCF4_22108803_ChIP-Seq_LS180_Human1.03305299
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03226474
128NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03144200
129CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02371008
130RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01632744
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01559937
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00535927
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99851640
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99829890
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.99734101
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97776014
137KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95220133
138SOX2_16153702_ChIP-ChIP_HESCs_Human0.94894715
139SPI1_23547873_ChIP-Seq_NB4_Human0.94854707
140NANOG_19829295_ChIP-Seq_ESCs_Human0.94554727
141SOX2_19829295_ChIP-Seq_ESCs_Human0.94554727
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.93487611
143RUNX2_22187159_ChIP-Seq_PCA_Human0.92878444
144SRF_21415370_ChIP-Seq_HL-1_Mouse0.92764728
145TP53_22573176_ChIP-Seq_HFKS_Human0.92734604
146GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92301252
147P53_22387025_ChIP-Seq_ESCs_Mouse0.91280096
148NOTCH1_21737748_ChIP-Seq_TLL_Human0.90984642
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90804532
150FLI1_21867929_ChIP-Seq_TH2_Mouse0.90405485
151MYC_18940864_ChIP-ChIP_HL60_Human0.89744053
152NANOG_21062744_ChIP-ChIP_HESCs_Human0.89384292
153NANOG_16153702_ChIP-ChIP_HESCs_Human0.88894568
154JUN_21703547_ChIP-Seq_K562_Human0.88889314
155E2F1_18555785_Chip-Seq_ESCs_Mouse0.88868470
156KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85669495
157CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85530578
158NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84210439
159SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83981917
160TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82068287
161ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81013522
162IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.76553468
163MYB_26560356_Chip-Seq_TH1_Human0.75957307
164ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75526765
165TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75366825
166MYB_21317192_ChIP-Seq_ERMYB_Mouse0.74753090
167MYB_26560356_Chip-Seq_TH2_Human0.74593636
168BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.73198818
169CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72523001

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.04950018
2MP0010094_abnormal_chromosome_stability5.00596458
3MP0003111_abnormal_nucleus_morphology4.55273686
4MP0008057_abnormal_DNA_replication4.48851705
5MP0003077_abnormal_cell_cycle4.01781118
6MP0004957_abnormal_blastocyst_morpholog4.00106937
7MP0008058_abnormal_DNA_repair3.23912961
8MP0002396_abnormal_hematopoietic_system2.82488768
9MP0008007_abnormal_cellular_replicative2.74034078
10MP0009697_abnormal_copulation2.56796875
11MP0008932_abnormal_embryonic_tissue2.43137062
12MP0010352_gastrointestinal_tract_polyps2.40563943
13MP0010307_abnormal_tumor_latency2.38606343
14MP0008877_abnormal_DNA_methylation2.34324681
15MP0000350_abnormal_cell_proliferation2.30930600
16MP0001730_embryonic_growth_arrest2.27851778
17MP0003123_paternal_imprinting2.10616553
18MP0002938_white_spotting1.99596403
19MP0000569_abnormal_digit_pigmentation1.97708068
20MP0003136_yellow_coat_color1.89705548
21MP0000490_abnormal_crypts_of1.89211057
22MP0004808_abnormal_hematopoietic_stem1.84128610
23MP0003195_calcinosis1.81126516
24MP0001672_abnormal_embryogenesis/_devel1.78338444
25MP0005380_embryogenesis_phenotype1.78338444
26MP0000372_irregular_coat_pigmentation1.75689187
27MP0003786_premature_aging1.73970721
28MP0001697_abnormal_embryo_size1.72700538
29MP0006072_abnormal_retinal_apoptosis1.64370733
30MP0000427_abnormal_hair_cycle1.61876908
31MP0003984_embryonic_growth_retardation1.60985355
32MP0003121_genomic_imprinting1.58054496
33MP0002088_abnormal_embryonic_growth/wei1.57333133
34MP0005551_abnormal_eye_electrophysiolog1.55229078
35MP0002080_prenatal_lethality1.55147455
36MP0002085_abnormal_embryonic_tissue1.54444510
37MP0002019_abnormal_tumor_incidence1.51845602
38MP0005076_abnormal_cell_differentiation1.51781556
39MP0002086_abnormal_extraembryonic_tissu1.51750485
40MP0005397_hematopoietic_system_phenotyp1.51329221
41MP0001545_abnormal_hematopoietic_system1.51329221
42MP0002084_abnormal_developmental_patter1.50151725
43MP0004197_abnormal_fetal_growth/weight/1.49273744
44MP0000313_abnormal_cell_death1.46947166
45MP0000383_abnormal_hair_follicle1.39601015
46MP0005253_abnormal_eye_physiology1.39308978
47MP0004043_abnormal_pH_regulation1.38397532
48MP0003567_abnormal_fetal_cardiomyocyte1.36035660
49MP0003763_abnormal_thymus_physiology1.34510801
50MP0001485_abnormal_pinna_reflex1.32963615
51MP0002234_abnormal_pharynx_morphology1.32272893
52MP0003646_muscle_fatigue1.31555312
53MP0002398_abnormal_bone_marrow1.30497035
54MP0000703_abnormal_thymus_morphology1.29519225
55MP0000631_abnormal_neuroendocrine_gland1.29264477
56MP0008789_abnormal_olfactory_epithelium1.28894462
57MP0001293_anophthalmia1.27172141
58MP0002210_abnormal_sex_determination1.22715318
59MP0002751_abnormal_autonomic_nervous1.20183785
60MP0004147_increased_porphyrin_level1.20082588
61MP0009333_abnormal_splenocyte_physiolog1.18863451
62MP0009278_abnormal_bone_marrow1.15910138
63MP0003718_maternal_effect1.15261339
64MP0002722_abnormal_immune_system1.15207014
65MP0003890_abnormal_embryonic-extraembry1.14678794
66MP0002736_abnormal_nociception_after1.14032701
67MP0000689_abnormal_spleen_morphology1.10761586
68MP0001145_abnormal_male_reproductive1.07064323
69MP0003698_abnormal_male_reproductive1.03955004
70MP0008872_abnormal_physiological_respon1.02058582
71MP0001929_abnormal_gametogenesis0.99936905
72MP0002233_abnormal_nose_morphology0.99221867
73MP0000647_abnormal_sebaceous_gland0.96259937
74MP0003880_abnormal_central_pattern0.95963636
75MP0005391_vision/eye_phenotype0.95601066
76MP0006054_spinal_hemorrhage0.95411595
77MP0002429_abnormal_blood_cell0.95160645
78MP0005395_other_phenotype0.94591271
79MP0005499_abnormal_olfactory_system0.94385183
80MP0005394_taste/olfaction_phenotype0.94385183
81MP0009672_abnormal_birth_weight0.94160261
82MP0001529_abnormal_vocalization0.93848515
83MP0005171_absent_coat_pigmentation0.93291240
84MP0009046_muscle_twitch0.93191446
85MP0005367_renal/urinary_system_phenotyp0.92328217
86MP0000516_abnormal_urinary_system0.92328217
87MP0003705_abnormal_hypodermis_morpholog0.92273501
88MP0000653_abnormal_sex_gland0.91716331
89MP0005646_abnormal_pituitary_gland0.91516864
90MP0000778_abnormal_nervous_system0.90752475
91MP0008995_early_reproductive_senescence0.89064164
92MP0006292_abnormal_olfactory_placode0.87635574
93MP0001119_abnormal_female_reproductive0.87592772
94MP0009703_decreased_birth_body0.87161063
95MP0010030_abnormal_orbit_morphology0.87061121
96MP0001915_intracranial_hemorrhage0.86895055
97MP0000049_abnormal_middle_ear0.86677961
98MP0001968_abnormal_touch/_nociception0.85882520
99MP0000716_abnormal_immune_system0.85510675
100MP0003755_abnormal_palate_morphology0.85382909
101MP0003943_abnormal_hepatobiliary_system0.84965957
102MP0004133_heterotaxia0.84198184
103MP0000858_altered_metastatic_potential0.84097038
104MP0005621_abnormal_cell_physiology0.81024575
105MP0005195_abnormal_posterior_eye0.80795101
106MP0010678_abnormal_skin_adnexa0.80771267
107MP0002090_abnormal_vision0.80523442
108MP0005384_cellular_phenotype0.79610094
109MP0000566_synostosis0.78988732
110MP0000685_abnormal_immune_system0.78836422
111MP0001486_abnormal_startle_reflex0.78690828
112MP0003861_abnormal_nervous_system0.78194204
113MP0005075_abnormal_melanosome_morpholog0.77578903
114MP0003315_abnormal_perineum_morphology0.77270306
115MP0003937_abnormal_limbs/digits/tail_de0.77269418
116MP0000537_abnormal_urethra_morphology0.76801394
117MP0002653_abnormal_ependyma_morphology0.76741137
118MP0001800_abnormal_humoral_immune0.76676714
119MP0001324_abnormal_eye_pigmentation0.76649246
120MP0002638_abnormal_pupillary_reflex0.76064140
121MP0002282_abnormal_trachea_morphology0.75951929
122MP0003119_abnormal_digestive_system0.75921070
123MP0002092_abnormal_eye_morphology0.75771030
124MP0002006_tumorigenesis0.75297455
125MP0001177_atelectasis0.73795011
126MP0001835_abnormal_antigen_presentation0.72843397
127MP0002160_abnormal_reproductive_system0.72678385
128MP0005174_abnormal_tail_pigmentation0.72643342
129MP0002166_altered_tumor_susceptibility0.71512921
130MP0003448_altered_tumor_morphology0.70343317
131MP0004215_abnormal_myocardial_fiber0.70307361
132MP0009053_abnormal_anal_canal0.69949179
133MP0003938_abnormal_ear_development0.69538059
134MP0000477_abnormal_intestine_morphology0.69014818
135MP0002075_abnormal_coat/hair_pigmentati0.68316957
136MP0002111_abnormal_tail_morphology0.67943263
137MP0002420_abnormal_adaptive_immunity0.67653020
138MP0003566_abnormal_cell_adhesion0.67604504
139MP0001819_abnormal_immune_cell0.66957005
140MP0002095_abnormal_skin_pigmentation0.65049425
141MP0002452_abnormal_antigen_presenting0.63239157
142MP0005023_abnormal_wound_healing0.62904285
143MP0004264_abnormal_extraembryonic_tissu0.62553201
144MP0000358_abnormal_cell_content/0.61056915
145MP0005671_abnormal_response_to0.60576298
146MP0002102_abnormal_ear_morphology0.59788141
147MP0001286_abnormal_eye_development0.58512043
148MP0002405_respiratory_system_inflammati0.57826959
149MP0000371_diluted_coat_color0.57322003
150MP0005389_reproductive_system_phenotype0.56611909
151MP0008770_decreased_survivor_rate0.56553758
152MP0000428_abnormal_craniofacial_morphol0.56022853
153MP0000465_gastrointestinal_hemorrhage0.54886488
154MP0003787_abnormal_imprinting0.54665394
155MP0002697_abnormal_eye_size0.54301032

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.93684793
2Birth length less than 3rd percentile (HP:0003561)4.79687314
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.61146659
4Abnormality of chromosome stability (HP:0003220)3.96045117
5Reticulocytopenia (HP:0001896)3.83784293
6Meckel diverticulum (HP:0002245)3.53104095
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.46132379
8Abnormality of the preputium (HP:0100587)3.43683373
9Pancreatic cysts (HP:0001737)3.43296564
10Abnormality of the ileum (HP:0001549)3.39305550
11Ependymoma (HP:0002888)3.36201527
12Colon cancer (HP:0003003)3.33199893
13Selective tooth agenesis (HP:0001592)3.31153993
14Medulloblastoma (HP:0002885)3.28361953
15Breast hypoplasia (HP:0003187)3.22896759
16Patellar aplasia (HP:0006443)3.14869757
17Impulsivity (HP:0100710)3.10480086
18Pancreatic fibrosis (HP:0100732)3.09136960
19Myelodysplasia (HP:0002863)3.07495305
20Oral leukoplakia (HP:0002745)3.05805997
21Molar tooth sign on MRI (HP:0002419)3.04247741
22Abnormality of midbrain morphology (HP:0002418)3.04247741
23Ectopic kidney (HP:0000086)3.02670627
24True hermaphroditism (HP:0010459)3.01663114
25Duodenal stenosis (HP:0100867)2.99231666
26Small intestinal stenosis (HP:0012848)2.99231666
27Aplasia/Hypoplasia of the patella (HP:0006498)2.97260323
28Abnormality of cells of the erythroid lineage (HP:0012130)2.97106977
29Abnormal number of erythroid precursors (HP:0012131)2.85994988
30Agnosia (HP:0010524)2.81811707
31Volvulus (HP:0002580)2.81713994
32Absent thumb (HP:0009777)2.80793484
33Nephronophthisis (HP:0000090)2.75803652
34Rhabdomyosarcoma (HP:0002859)2.72282398
35Abnormality of the carotid arteries (HP:0005344)2.66401346
36Increased nuchal translucency (HP:0010880)2.63867907
37Bone marrow hypocellularity (HP:0005528)2.59924287
38Absent radius (HP:0003974)2.56321565
39Aplastic anemia (HP:0001915)2.55173779
40Abnormal number of incisors (HP:0011064)2.50787033
41Prominent nose (HP:0000448)2.49234979
42Abnormality of the fingertips (HP:0001211)2.48858368
43Sloping forehead (HP:0000340)2.48213761
44Proximal placement of thumb (HP:0009623)2.47514045
45Abnormality of the duodenum (HP:0002246)2.46297800
46Intestinal atresia (HP:0011100)2.45574933
47Abnormality of the renal medulla (HP:0100957)2.44113910
48Basal cell carcinoma (HP:0002671)2.43497201
49Deviation of the thumb (HP:0009603)2.39666134
50Abnormality of the anterior horn cell (HP:0006802)2.39037649
51Degeneration of anterior horn cells (HP:0002398)2.39037649
52Duplicated collecting system (HP:0000081)2.38581204
5311 pairs of ribs (HP:0000878)2.38344590
54Cafe-au-lait spot (HP:0000957)2.36637511
55Absent forearm bone (HP:0003953)2.36422192
56Aplasia involving forearm bones (HP:0009822)2.36422192
57Abnormality of the renal cortex (HP:0011035)2.35615695
58Abnormality of the labia minora (HP:0012880)2.35291880
59Clubbing of toes (HP:0100760)2.32629159
60Neoplasm of the pancreas (HP:0002894)2.30955181
61Tracheoesophageal fistula (HP:0002575)2.28920637
62Premature graying of hair (HP:0002216)2.25510520
63Small hand (HP:0200055)2.23146552
64High pitched voice (HP:0001620)2.22323843
65Chronic hepatic failure (HP:0100626)2.21535794
66Abnormality of the astrocytes (HP:0100707)2.21427116
67Astrocytoma (HP:0009592)2.21427116
68Atresia of the external auditory canal (HP:0000413)2.20645136
69Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20441933
70Short 4th metacarpal (HP:0010044)2.20441933
71Amaurosis fugax (HP:0100576)2.18707545
72Short thumb (HP:0009778)2.18105707
73Carpal bone hypoplasia (HP:0001498)2.16132686
74Rough bone trabeculation (HP:0100670)2.14828070
75Abnormality of DNA repair (HP:0003254)2.14015499
76Neoplasm of the oral cavity (HP:0100649)2.13837956
77Facial hemangioma (HP:0000329)2.13684048
78Thrombocytosis (HP:0001894)2.13578703
79Abnormality of the renal collecting system (HP:0004742)2.13138397
80Pallor (HP:0000980)2.12871210
81Abnormal lung lobation (HP:0002101)2.12646956
82Lymphoma (HP:0002665)2.11807296
83Astigmatism (HP:0000483)2.11732386
84Oligodactyly (hands) (HP:0001180)2.10869505
85Hyperventilation (HP:0002883)2.10732324
86Cellular immunodeficiency (HP:0005374)2.10598371
87Preaxial hand polydactyly (HP:0001177)2.10384169
88Squamous cell carcinoma (HP:0002860)2.10303341
89Neoplasm of striated muscle (HP:0009728)2.08509142
90Triphalangeal thumb (HP:0001199)2.08018663
91Aplasia/Hypoplasia of the tongue (HP:0010295)2.07020480
92Glioma (HP:0009733)2.05895484
93Cystic liver disease (HP:0006706)2.04913868
94Abolished electroretinogram (ERG) (HP:0000550)2.04143878
95Microretrognathia (HP:0000308)2.02100416
96Dandy-Walker malformation (HP:0001305)2.00907239
97Congenital stationary night blindness (HP:0007642)1.98786011
98Pendular nystagmus (HP:0012043)1.97324435
99Acute myeloid leukemia (HP:0004808)1.96499894
100Overlapping toe (HP:0001845)1.94877738
101Aplasia/Hypoplasia of the sternum (HP:0006714)1.93998824
102Aqueductal stenosis (HP:0002410)1.93902947
103Nephroblastoma (Wilms tumor) (HP:0002667)1.93067418
104Horseshoe kidney (HP:0000085)1.92555006
105Gaze-evoked nystagmus (HP:0000640)1.92257580
106Missing ribs (HP:0000921)1.92024601
107Sclerocornea (HP:0000647)1.91942464
108Abnormality of the pons (HP:0007361)1.91294437
109Anencephaly (HP:0002323)1.90462358
110Abnormality of alanine metabolism (HP:0010916)1.88872638
111Hyperalaninemia (HP:0003348)1.88872638
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88872638
113Postaxial foot polydactyly (HP:0001830)1.88833124
114Supernumerary spleens (HP:0009799)1.88435644
115Long eyelashes (HP:0000527)1.87550511
116Oligohydramnios (HP:0001562)1.87142505
117Hypoplasia of the pons (HP:0012110)1.86206325
118Bile duct proliferation (HP:0001408)1.84397048
119Abnormal biliary tract physiology (HP:0012439)1.84397048
120Protruding tongue (HP:0010808)1.83496186
121Slender long bone (HP:0003100)1.82675398
122Progressive inability to walk (HP:0002505)1.79949375
123Aplasia/Hypoplasia of the tibia (HP:0005772)1.79842091
124Embryonal renal neoplasm (HP:0011794)1.79680117
125Leukopenia (HP:0001882)1.79497131
126Macrocytic anemia (HP:0001972)1.79010423
127IgM deficiency (HP:0002850)1.78633420
128Abnormality of reticulocytes (HP:0004312)1.78204311
129Medial flaring of the eyebrow (HP:0010747)1.77869522
130Arteriovenous malformation (HP:0100026)1.76673375
131Tubular atrophy (HP:0000092)1.76629597
132Bifid tongue (HP:0010297)1.76284129
133Cleft eyelid (HP:0000625)1.76210274
134Neoplasm of the colon (HP:0100273)1.73624236
135Aganglionic megacolon (HP:0002251)1.72711868
136Neoplasm of the adrenal cortex (HP:0100641)1.72588966
137Gastrointestinal atresia (HP:0002589)1.70839865
138Attenuation of retinal blood vessels (HP:0007843)1.70290408
139Poikiloderma (HP:0001029)1.70192911
140Choanal atresia (HP:0000453)1.68316743
141Biliary tract neoplasm (HP:0100574)1.67498454
142Acute lymphatic leukemia (HP:0006721)1.66708655
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66576032
144Hypoplastic labia majora (HP:0000059)1.65397006
145Sandal gap (HP:0001852)1.65308997
146Abnormality of pyrimidine metabolism (HP:0004353)1.64603638
147Renal cortical cysts (HP:0000803)1.62793686
148Optic nerve hypoplasia (HP:0000609)1.60737038
149Fair hair (HP:0002286)1.60346892
150Pancreatic islet-cell hyperplasia (HP:0004510)1.60039451
151Congenital hepatic fibrosis (HP:0002612)1.59995472
152Oligodactyly (HP:0012165)1.59119849
153Highly arched eyebrow (HP:0002553)1.57040918
154Hypoplastic iliac wings (HP:0002866)1.56474821
155Renal hypoplasia (HP:0000089)1.55497051
156Holoprosencephaly (HP:0001360)1.53262638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.39775459
2FRK4.60987912
3WEE14.06938698
4BUB13.75160237
5NEK23.35232296
6BMPR1B3.16292597
7NUAK12.76820830
8TTK2.56831343
9CDK122.49297095
10SRPK12.48856250
11EIF2AK12.41403857
12ACVR1B2.34032678
13TRIM282.30636742
14WNK32.27007532
15PLK42.26861042
16PLK12.10172445
17ATR2.04542251
18NEK12.01985285
19TNIK1.96961869
20BRSK21.92603729
21AURKB1.88031798
22CDK71.81983298
23DYRK31.79936264
24CHEK21.79463893
25TLK11.76651680
26PNCK1.75975480
27CDK41.72680006
28MKNK11.71540500
29EEF2K1.71219918
30VRK11.68653245
31RPS6KA41.64283730
32MAP3K101.58509072
33RPS6KB21.57410247
34PASK1.56610060
35TSSK61.54274156
36SCYL21.51409752
37STK101.49334944
38MAP4K21.47416331
39MAP3K81.46102625
40NME21.45290527
41STK41.42545933
42CHEK11.41093362
43PLK31.40242599
44EIF2AK31.38656167
45MKNK21.37909230
46STK391.33197276
47TAF11.32588411
48BRD41.28142496
49ERBB31.25985017
50MAPK131.25262188
51PKN21.18512843
52ZAK1.17744659
53PIM11.16344430
54PLK21.16078745
55ADRBK21.13831317
56AURKA1.13731430
57MAP4K11.13579974
58ATM1.13549998
59FLT31.12948384
60BRSK11.08667408
61TESK21.07439077
62OXSR11.06441799
63GRK11.05030049
64PBK1.03013033
65STK31.02527924
66INSRR1.01658299
67CDK60.99919558
68CDK20.97565748
69TGFBR10.95200700
70MAP3K40.91671139
71CCNB10.91112937
72EPHA40.89299849
73VRK20.88531179
74STK160.88100235
75CASK0.87902745
76CDK80.84410538
77MST40.83977989
78PINK10.81557465
79CAMK1G0.80221383
80WNK40.77703125
81PAK40.76937693
82NLK0.76721116
83CDK10.74430957
84MELK0.74089071
85ALK0.73076287
86FGFR20.69813840
87BCR0.68332371
88EIF2AK20.67707376
89EPHA20.67644960
90JAK30.64765512
91CLK10.64028022
92LRRK20.63771462
93MAP2K30.63092946
94CSNK2A20.59532290
95RPS6KA50.58372703
96CAMK1D0.57010417
97CSNK1G10.55061469
98CSNK2A10.53692308
99BTK0.51659992
100MTOR0.51531429
101CDK30.51227102
102PKN10.50604831
103PAK30.48053159
104PAK10.47121817
105CSF1R0.46819099
106AKT20.45988706
107IRAK10.45831070
108PRKCG0.45251956
109TEC0.43481325
110CDK90.42818428
111PRKDC0.42719114
112PRKCE0.42689388
113ADRBK10.42443840
114LATS10.41807240
115AKT30.41622096
116GRK60.40987491
117FGFR10.40569292
118MARK30.40290623
119DYRK20.39421028
120TYK20.38206681
121KIT0.38045952
122BRAF0.36084035
123CSNK1D0.35343307
124ZAP700.32682776
125MAPK140.32352863
126PIM20.31404508
127CSNK1G20.30531190
128PRKCI0.30454788
129MAPKAPK50.30335794
130NME10.28563770
131CSNK1A1L0.28284016
132AKT10.28097465
133PDK20.27581265
134MAPK110.26847542
135CSNK1G30.26654175
136RAF10.26221192
137NEK90.25709671
138MAPKAPK30.23875008
139PAK20.22755036
140CSNK1A10.22272509
141FER0.22148084
142CSNK1E0.21720913
143MAPK10.21356310
144YES10.19410329
145STK38L0.19397422
146TIE10.19312863
147CHUK0.18128254
148GSK3B0.17852832
149LYN0.16937954
150TXK0.16669393

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.38005454
2Mismatch repair_Homo sapiens_hsa034304.49893603
3Homologous recombination_Homo sapiens_hsa034403.27459639
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25213325
5Base excision repair_Homo sapiens_hsa034103.19961166
6Cell cycle_Homo sapiens_hsa041103.14611681
7Spliceosome_Homo sapiens_hsa030403.03330758
8RNA transport_Homo sapiens_hsa030132.94241036
9Nucleotide excision repair_Homo sapiens_hsa034202.85126760
10One carbon pool by folate_Homo sapiens_hsa006702.71119102
11Fanconi anemia pathway_Homo sapiens_hsa034602.62584886
12RNA polymerase_Homo sapiens_hsa030202.48305359
13Ribosome_Homo sapiens_hsa030102.45893028
14Non-homologous end-joining_Homo sapiens_hsa034502.34438270
15Pyrimidine metabolism_Homo sapiens_hsa002402.21351132
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16642273
17Proteasome_Homo sapiens_hsa030501.95795507
18RNA degradation_Homo sapiens_hsa030181.91065927
19Basal transcription factors_Homo sapiens_hsa030221.86575631
20mRNA surveillance pathway_Homo sapiens_hsa030151.85061631
21Propanoate metabolism_Homo sapiens_hsa006401.80707555
22p53 signaling pathway_Homo sapiens_hsa041151.79130146
23Systemic lupus erythematosus_Homo sapiens_hsa053221.77408128
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73836196
25Protein export_Homo sapiens_hsa030601.62118721
26Phototransduction_Homo sapiens_hsa047441.52690847
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51900009
28Butanoate metabolism_Homo sapiens_hsa006501.44241849
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42920633
30Nitrogen metabolism_Homo sapiens_hsa009101.37150802
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29074440
32Herpes simplex infection_Homo sapiens_hsa051681.26516181
33Viral carcinogenesis_Homo sapiens_hsa052031.22704091
34Tryptophan metabolism_Homo sapiens_hsa003801.16644956
35Antigen processing and presentation_Homo sapiens_hsa046121.16562405
36Nicotine addiction_Homo sapiens_hsa050331.16544767
37Epstein-Barr virus infection_Homo sapiens_hsa051691.13619221
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11037271
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09112724
40Purine metabolism_Homo sapiens_hsa002301.08926482
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06155006
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02060869
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01306958
44Linoleic acid metabolism_Homo sapiens_hsa005911.00882791
45Oocyte meiosis_Homo sapiens_hsa041140.97648301
46HTLV-I infection_Homo sapiens_hsa051660.95207230
47MicroRNAs in cancer_Homo sapiens_hsa052060.91912904
48Small cell lung cancer_Homo sapiens_hsa052220.90713535
49Steroid biosynthesis_Homo sapiens_hsa001000.88255718
50Caffeine metabolism_Homo sapiens_hsa002320.88005425
51Ether lipid metabolism_Homo sapiens_hsa005650.87170287
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86152012
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85716746
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82849977
55Selenocompound metabolism_Homo sapiens_hsa004500.81334386
56Primary immunodeficiency_Homo sapiens_hsa053400.79975144
57Olfactory transduction_Homo sapiens_hsa047400.77720942
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77102855
59Hedgehog signaling pathway_Homo sapiens_hsa043400.75200926
60Taste transduction_Homo sapiens_hsa047420.74334025
61Alcoholism_Homo sapiens_hsa050340.71924012
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71716127
63Thyroid cancer_Homo sapiens_hsa052160.69930043
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69069929
65Pyruvate metabolism_Homo sapiens_hsa006200.68174109
66Apoptosis_Homo sapiens_hsa042100.67741553
67Pentose phosphate pathway_Homo sapiens_hsa000300.66426813
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.65019455
69Hepatitis B_Homo sapiens_hsa051610.63271107
70Measles_Homo sapiens_hsa051620.62764811
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.62450674
72Chronic myeloid leukemia_Homo sapiens_hsa052200.62174848
73Legionellosis_Homo sapiens_hsa051340.61815473
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.61627225
75Colorectal cancer_Homo sapiens_hsa052100.61363872
76Glycerolipid metabolism_Homo sapiens_hsa005610.60978639
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.57139330
78Retinol metabolism_Homo sapiens_hsa008300.55432483
79Biosynthesis of amino acids_Homo sapiens_hsa012300.54887722
80Folate biosynthesis_Homo sapiens_hsa007900.53840526
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52600442
82Sulfur relay system_Homo sapiens_hsa041220.52408878
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52383122
84Huntingtons disease_Homo sapiens_hsa050160.52188394
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52152492
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.51932881
87Notch signaling pathway_Homo sapiens_hsa043300.51374213
88Peroxisome_Homo sapiens_hsa041460.51002513
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48269335
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48242077
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47935252
92TGF-beta signaling pathway_Homo sapiens_hsa043500.47849671
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47802827
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47671952
95Vitamin B6 metabolism_Homo sapiens_hsa007500.46259614
96Viral myocarditis_Homo sapiens_hsa054160.45695945
97beta-Alanine metabolism_Homo sapiens_hsa004100.45538228
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.45407617
99Metabolic pathways_Homo sapiens_hsa011000.45395761
100Chemical carcinogenesis_Homo sapiens_hsa052040.44891943
101Influenza A_Homo sapiens_hsa051640.44826810
102Basal cell carcinoma_Homo sapiens_hsa052170.44642249
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43277063
104Fatty acid metabolism_Homo sapiens_hsa012120.42965835
105Lysine degradation_Homo sapiens_hsa003100.42820486
106Fatty acid degradation_Homo sapiens_hsa000710.42269833
107Hematopoietic cell lineage_Homo sapiens_hsa046400.41663556
108Wnt signaling pathway_Homo sapiens_hsa043100.41538445
109ABC transporters_Homo sapiens_hsa020100.40941694
110Fatty acid elongation_Homo sapiens_hsa000620.40665188
111Hippo signaling pathway_Homo sapiens_hsa043900.40534277
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40076350
113Histidine metabolism_Homo sapiens_hsa003400.39818673
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38840939
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38717396
116Shigellosis_Homo sapiens_hsa051310.38208060
117Pancreatic cancer_Homo sapiens_hsa052120.37661100
118Acute myeloid leukemia_Homo sapiens_hsa052210.37031886
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.36358254
120Pathways in cancer_Homo sapiens_hsa052000.36317673
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36211045
122Non-small cell lung cancer_Homo sapiens_hsa052230.35458233
123Regulation of autophagy_Homo sapiens_hsa041400.34926656
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.34451706
125Parkinsons disease_Homo sapiens_hsa050120.34336728
126Bladder cancer_Homo sapiens_hsa052190.33777641
127Morphine addiction_Homo sapiens_hsa050320.33769166
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33288724
129Prostate cancer_Homo sapiens_hsa052150.32792052
130N-Glycan biosynthesis_Homo sapiens_hsa005100.32356279
131mTOR signaling pathway_Homo sapiens_hsa041500.31555309
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31310032
133Oxidative phosphorylation_Homo sapiens_hsa001900.30882580
134B cell receptor signaling pathway_Homo sapiens_hsa046620.30772394
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.29414856
136Vitamin digestion and absorption_Homo sapiens_hsa049770.27718517
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27369478
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26984789
139Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26916602
140Adherens junction_Homo sapiens_hsa045200.25219908
141Serotonergic synapse_Homo sapiens_hsa047260.24434239
142Allograft rejection_Homo sapiens_hsa053300.24156082
143HIF-1 signaling pathway_Homo sapiens_hsa040660.24105627
144Graft-versus-host disease_Homo sapiens_hsa053320.24081902
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.24047946
146Fatty acid biosynthesis_Homo sapiens_hsa000610.22585655
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22136037
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21903292
149Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21834496
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20842937
151Leishmaniasis_Homo sapiens_hsa051400.20625188
152Toxoplasmosis_Homo sapiens_hsa051450.19144470
153Fat digestion and absorption_Homo sapiens_hsa049750.18810522
154Ovarian steroidogenesis_Homo sapiens_hsa049130.18607968
155T cell receptor signaling pathway_Homo sapiens_hsa046600.18180925
156FoxO signaling pathway_Homo sapiens_hsa040680.18022105
157Renin-angiotensin system_Homo sapiens_hsa046140.17524267
158Glutathione metabolism_Homo sapiens_hsa004800.16780598
159Leukocyte transendothelial migration_Homo sapiens_hsa046700.15594389
160Endometrial cancer_Homo sapiens_hsa052130.14924781
161Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14583966

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »