MN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebral cortex radially oriented cell migration (GO:0021799)9.98474027
2limb bud formation (GO:0060174)7.56005788
3sympathetic nervous system development (GO:0048485)6.97104962
4glial cell proliferation (GO:0014009)6.95957090
5facial nerve structural organization (GO:0021612)6.47778565
6cardiac ventricle formation (GO:0003211)6.13059931
7cornea development in camera-type eye (GO:0061303)5.95521655
8pyrimidine nucleobase catabolic process (GO:0006208)5.89099423
9cerebral cortex cell migration (GO:0021795)5.78090926
10cardiac chamber formation (GO:0003207)5.74030350
11spinal cord development (GO:0021510)5.67450017
12cranial nerve morphogenesis (GO:0021602)5.40189459
13somite development (GO:0061053)5.27904312
14central nervous system projection neuron axonogenesis (GO:0021952)5.18334912
15lens morphogenesis in camera-type eye (GO:0002089)4.98583511
16neural tube formation (GO:0001841)4.91472203
17specification of organ identity (GO:0010092)4.88641938
18cranial nerve structural organization (GO:0021604)4.85263293
19embryonic digestive tract morphogenesis (GO:0048557)4.76713587
20artery development (GO:0060840)4.70229861
21cell differentiation involved in kidney development (GO:0061005)4.59488287
22negative regulation of axon extension involved in axon guidance (GO:0048843)4.58158717
23presynaptic membrane assembly (GO:0097105)4.46455775
24tongue development (GO:0043586)4.42953259
25startle response (GO:0001964)4.42470902
26ganglion development (GO:0061548)4.32840070
27sarcoplasmic reticulum calcium ion transport (GO:0070296)4.31069902
28negative regulation of alpha-beta T cell differentiation (GO:0046639)4.25256596
29nucleobase catabolic process (GO:0046113)4.22311999
30negative regulation of axon guidance (GO:1902668)4.17717096
31auditory behavior (GO:0031223)4.16574952
32regulation of hippo signaling (GO:0035330)4.11460410
33telencephalon cell migration (GO:0022029)4.05299641
34presynaptic membrane organization (GO:0097090)4.04313144
35postsynaptic membrane organization (GO:0001941)4.04285276
36positive regulation of male gonad development (GO:2000020)4.03362869
37cranial suture morphogenesis (GO:0060363)4.03056185
38central nervous system neuron axonogenesis (GO:0021955)4.01179589
39regulation of male gonad development (GO:2000018)3.98993504
40negative regulation of transcription regulatory region DNA binding (GO:2000678)3.95823528
41axon extension involved in axon guidance (GO:0048846)3.93728252
42neuron projection extension involved in neuron projection guidance (GO:1902284)3.93728252
43receptor recycling (GO:0001881)3.91292768
44axonal fasciculation (GO:0007413)3.88698872
45histone H3-K4 trimethylation (GO:0080182)3.87676142
46cell differentiation involved in metanephros development (GO:0072202)3.84098838
47regulation of collateral sprouting (GO:0048670)3.81611361
48cell proliferation in forebrain (GO:0021846)3.80363274
49actin-myosin filament sliding (GO:0033275)3.76002441
50muscle filament sliding (GO:0030049)3.76002441
51olfactory bulb development (GO:0021772)3.74953365
52mechanosensory behavior (GO:0007638)3.73971261
53neuroepithelial cell differentiation (GO:0060563)3.71734656
54negative chemotaxis (GO:0050919)3.70449820
55forebrain cell migration (GO:0021885)3.66359701
56RNA localization (GO:0006403)3.66336383
57negative regulation of glial cell proliferation (GO:0060253)3.65027022
58radial glial cell differentiation (GO:0060019)3.64562743
59negative regulation of dendrite development (GO:2000171)3.64524708
60eyelid development in camera-type eye (GO:0061029)3.57553327
61regulation of axon extension involved in axon guidance (GO:0048841)3.55393823
62neuron recognition (GO:0008038)3.53789334
63establishment of mitochondrion localization (GO:0051654)3.48505437
64positive regulation of neuroblast proliferation (GO:0002052)3.46437054
65regulation of axon guidance (GO:1902667)3.41315702
66regulation of pigment cell differentiation (GO:0050932)3.39901022
67otic vesicle formation (GO:0030916)3.31543275
68craniofacial suture morphogenesis (GO:0097094)3.29609601
69cerebellar granule cell differentiation (GO:0021707)3.28762367
70camera-type eye morphogenesis (GO:0048593)3.25106662
71lung morphogenesis (GO:0060425)3.23664622
72actin-mediated cell contraction (GO:0070252)3.19907727
73ionotropic glutamate receptor signaling pathway (GO:0035235)3.19475287
74neuron cell-cell adhesion (GO:0007158)3.17471948
75dendritic spine morphogenesis (GO:0060997)3.16104535
76myelination in peripheral nervous system (GO:0022011)3.15485324
77peripheral nervous system axon ensheathment (GO:0032292)3.15485324
78neuronal stem cell maintenance (GO:0097150)3.12104923
79positive regulation of amino acid transport (GO:0051957)3.11485442
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11453071
81lateral sprouting from an epithelium (GO:0060601)3.11376568
82retinal ganglion cell axon guidance (GO:0031290)3.09779965
83anatomical structure arrangement (GO:0048532)3.08295255
84proximal/distal pattern formation (GO:0009954)3.06613075
85cellular response to prostaglandin stimulus (GO:0071379)3.05410203
86axon extension (GO:0048675)3.03734331
87establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.03460490
88mitochondrion transport along microtubule (GO:0047497)3.03460490
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00705575
90regulation of respiratory system process (GO:0044065)2.99256020
91regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.98694556
92substrate-dependent cell migration (GO:0006929)2.98009048
93regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.97677452
94regulation of synapse assembly (GO:0051963)2.97279502
95glial cell development (GO:0021782)2.96376731
96layer formation in cerebral cortex (GO:0021819)2.92998694
97cell migration in hindbrain (GO:0021535)2.92958226
98neuron fate determination (GO:0048664)2.92833662
99vocalization behavior (GO:0071625)2.92075901
100hippocampus development (GO:0021766)2.91290303
101oligodendrocyte development (GO:0014003)2.91186914
102negative regulation of smoothened signaling pathway (GO:0045879)2.87593992
103ventricular septum morphogenesis (GO:0060412)2.87554992
104histone H2B ubiquitination (GO:0033523)2.87507223
105myofibril assembly (GO:0030239)2.87454937
106glutamate receptor signaling pathway (GO:0007215)2.86733796
107neuronal action potential propagation (GO:0019227)2.86335236
108interleukin-6-mediated signaling pathway (GO:0070102)2.86152117
109myotube differentiation (GO:0014902)2.84939559
110dentate gyrus development (GO:0021542)2.82788909
111positive regulation of dendritic spine morphogenesis (GO:0061003)2.81435993
112dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.80279049
113oligodendrocyte differentiation (GO:0048709)2.79934372
114synapse assembly (GO:0007416)2.79433777
115regulation of synapse structural plasticity (GO:0051823)2.79347709
116nonmotile primary cilium assembly (GO:0035058)2.79037914
117negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.78255153
118neuron projection extension (GO:1990138)2.77166358
119cardiac myofibril assembly (GO:0055003)2.76627393
120epithelial cell differentiation involved in kidney development (GO:0035850)2.75249047
121pericardium development (GO:0060039)2.74589240
122positive regulation of synapse assembly (GO:0051965)2.73941082
123generation of neurons (GO:0048699)2.71609245
124regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.71474365
125regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.70470682
126neuromuscular synaptic transmission (GO:0007274)2.69974841
127dendrite morphogenesis (GO:0048813)2.69866956
128negative regulation of astrocyte differentiation (GO:0048712)2.68224146
129regulation of neuroblast proliferation (GO:1902692)2.65479572
130short-term memory (GO:0007614)2.64910743
131neuron migration (GO:0001764)2.64881459
132metanephric nephron tubule development (GO:0072234)2.62856945
133metanephric tubule development (GO:0072170)2.62856945
134neurotransmitter-gated ion channel clustering (GO:0072578)2.62553177
135mesenchymal cell differentiation involved in renal system development (GO:2001012)2.62305447
136mesenchymal cell differentiation involved in kidney development (GO:0072161)2.62305447
137protein localization to synapse (GO:0035418)2.61101585
138calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.59351564
139regulation of synapse organization (GO:0050807)2.58643414
140metanephric mesenchyme development (GO:0072075)2.56416418
141regulation of dendritic spine morphogenesis (GO:0061001)2.53880174
142heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.53388309
143regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.52185703
144midbrain development (GO:0030901)2.51831004
145cochlea morphogenesis (GO:0090103)2.51679484
146forebrain neuron development (GO:0021884)2.51462534
147establishment of nucleus localization (GO:0040023)2.50912716
148limb development (GO:0060173)2.50148237
149appendage development (GO:0048736)2.50148237
150planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49557657
151dermatan sulfate biosynthetic process (GO:0030208)2.48920459
152synaptic transmission, glutamatergic (GO:0035249)2.48857855
153regulation of skeletal muscle contraction (GO:0014819)2.47965031
154response to inactivity (GO:0014854)2.46224145
155membrane assembly (GO:0071709)2.45674078
156astrocyte development (GO:0014002)2.45590044
157regulation of relaxation of muscle (GO:1901077)2.43958697
158negative regulation of oligodendrocyte differentiation (GO:0048715)2.43147843
159synapse organization (GO:0050808)2.42439090
160regulation of actin filament-based movement (GO:1903115)2.40901978
161axonogenesis (GO:0007409)2.40486436
162regulation of neuron migration (GO:2001222)2.39455758
163positive regulation of vascular permeability (GO:0043117)2.38340965

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.02745002
2GBX2_23144817_ChIP-Seq_PC3_Human4.29217584
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.95405889
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.33629396
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.68341429
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.49075706
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45554656
8IGF1R_20145208_ChIP-Seq_DFB_Human2.42907160
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.41760996
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37748124
11* CBX2_27304074_Chip-Seq_ESCs_Mouse2.33509472
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32683972
13TAF15_26573619_Chip-Seq_HEK293_Human2.30371177
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29299232
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.28368625
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28045141
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.27664986
18* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17202455
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.16195103
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15279400
21* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.14782064
22* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13630299
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09640837
24* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08627074
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07964050
26* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04342630
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02247927
28* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02088563
29* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02088563
30* P300_19829295_ChIP-Seq_ESCs_Human1.96360236
31* EZH2_27294783_Chip-Seq_ESCs_Mouse1.89566452
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85212052
33IRF1_19129219_ChIP-ChIP_H3396_Human1.84571115
34* SMAD3_21741376_ChIP-Seq_EPCs_Human1.83095547
35* REST_21632747_ChIP-Seq_MESCs_Mouse1.81682698
36* RNF2_27304074_Chip-Seq_ESCs_Mouse1.81302688
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.80252899
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79446483
39* RNF2_27304074_Chip-Seq_NSC_Mouse1.78089468
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67770175
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.64930383
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63775202
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63775202
44TP53_18474530_ChIP-ChIP_U2OS_Human1.62301850
45FUS_26573619_Chip-Seq_HEK293_Human1.60905667
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60214986
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55533605
48SMAD4_21799915_ChIP-Seq_A2780_Human1.51052737
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.47504402
50SOX9_26525672_Chip-Seq_HEART_Mouse1.44492430
51* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44193562
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43804910
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40353254
54* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40161972
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.38696861
56KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.38413279
57AR_25329375_ChIP-Seq_VCAP_Human1.38403427
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37357358
59FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36502341
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.35807364
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.34884185
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33658864
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33509225
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32530271
65ER_23166858_ChIP-Seq_MCF-7_Human1.31912469
66ZNF274_21170338_ChIP-Seq_K562_Hela1.30663987
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28346341
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.27071228
69AR_21572438_ChIP-Seq_LNCaP_Human1.26949337
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.25951630
71VDR_22108803_ChIP-Seq_LS180_Human1.25172460
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24646717
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.20105686
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.19945011
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19776595
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19743569
77EWS_26573619_Chip-Seq_HEK293_Human1.19570934
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.18714607
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18551920
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17794887
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17686611
82* ISL1_27105846_Chip-Seq_CPCs_Mouse1.17348482
83* RUNX2_22187159_ChIP-Seq_PCA_Human1.16958761
84* RING1B_27294783_Chip-Seq_NPCs_Mouse1.15254941
85* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14036337
86* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11185902
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.10974491
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10957122
89* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09424600
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09267140
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07267594
92TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06729546
93* RARB_27405468_Chip-Seq_BRAIN_Mouse1.06333556
94P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06030884
95GATA1_26923725_Chip-Seq_HPCs_Mouse1.05992003
96TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05392044
97* SOX2_21211035_ChIP-Seq_LN229_Gbm1.04973213
98RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04702144
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.03921097
100KDM2B_26808549_Chip-Seq_REH_Human1.03400128
101POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03315627
102* PRDM14_20953172_ChIP-Seq_ESCs_Human1.03219281
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03092661
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.02978346
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02667456
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.02133292
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.01717733
108TCF4_18268006_ChIP-ChIP_LS174T_Human1.00375822
109NANOG_18555785_Chip-Seq_ESCs_Mouse0.99161374
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99054775
111RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98900433
112DROSHA_22980978_ChIP-Seq_HELA_Human0.98322755
113* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98049448
114* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98049448
115TCF4_23295773_ChIP-Seq_U87_Human0.97961698
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95180442
117FLI1_27457419_Chip-Seq_LIVER_Mouse0.92956846
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92699663
119* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92605819
120SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92049735
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91609769
122AHR_22903824_ChIP-Seq_MCF-7_Human0.91043952
123STAT3_23295773_ChIP-Seq_U87_Human0.90596212
124WT1_19549856_ChIP-ChIP_CCG9911_Human0.90448266

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.32034970
2MP0006292_abnormal_olfactory_placode6.08533287
3MP0008789_abnormal_olfactory_epithelium3.85271806
4MP0010030_abnormal_orbit_morphology3.66891036
5MP0005248_abnormal_Harderian_gland3.35224873
6MP0005499_abnormal_olfactory_system3.32884465
7MP0005394_taste/olfaction_phenotype3.32884465
8MP0001188_hyperpigmentation2.79583030
9MP0003880_abnormal_central_pattern2.67850566
10MP0003787_abnormal_imprinting2.62633153
11MP0005409_darkened_coat_color2.51082675
12MP0004145_abnormal_muscle_electrophysio2.50109691
13MP0002249_abnormal_larynx_morphology2.41930922
14MP0000778_abnormal_nervous_system2.37170217
15MP0003385_abnormal_body_wall2.33443268
16MP0009053_abnormal_anal_canal2.21450725
17MP0002736_abnormal_nociception_after2.19952993
18MP0005423_abnormal_somatic_nervous2.17847044
19MP0002822_catalepsy2.12331280
20MP0002938_white_spotting2.12125652
21MP0004859_abnormal_synaptic_plasticity2.08158306
22MP0001968_abnormal_touch/_nociception2.01060306
23MP0002751_abnormal_autonomic_nervous2.00327284
24MP0000631_abnormal_neuroendocrine_gland1.93417771
25MP0002184_abnormal_innervation1.84736344
26MP0000749_muscle_degeneration1.84374902
27MP0005408_hypopigmentation1.83491943
28MP0003938_abnormal_ear_development1.81959974
29MP0009379_abnormal_foot_pigmentation1.78156137
30MP0000049_abnormal_middle_ear1.73340654
31MP0000015_abnormal_ear_pigmentation1.66257414
32MP0003646_muscle_fatigue1.63559123
33MP0000534_abnormal_ureter_morphology1.63000976
34MP0001299_abnormal_eye_distance/1.62196383
35MP0004134_abnormal_chest_morphology1.61330886
36MP0002234_abnormal_pharynx_morphology1.60068371
37MP0000579_abnormal_nail_morphology1.57673806
38MP0002063_abnormal_learning/memory/cond1.55230177
39MP0003635_abnormal_synaptic_transmissio1.54623180
40MP0002177_abnormal_outer_ear1.49333698
41MP0002102_abnormal_ear_morphology1.46757754
42MP0006276_abnormal_autonomic_nervous1.44389108
43MP0001984_abnormal_olfaction1.44151662
44MP0005503_abnormal_tendon_morphology1.44031377
45MP0002653_abnormal_ependyma_morphology1.44002289
46MP0002876_abnormal_thyroid_physiology1.41976038
47MP0003121_genomic_imprinting1.41706664
48MP0005187_abnormal_penis_morphology1.40499765
49MP0000537_abnormal_urethra_morphology1.36412524
50MP0008438_abnormal_cutaneous_collagen1.33308131
51MP0005646_abnormal_pituitary_gland1.32381147
52MP0000681_abnormal_thyroid_gland1.31935943
53MP0002106_abnormal_muscle_physiology1.31377275
54MP0002108_abnormal_muscle_morphology1.31272355
55MP0005369_muscle_phenotype1.28403494
56MP0004142_abnormal_muscle_tone1.26557306
57* MP0003755_abnormal_palate_morphology1.23822157
58MP0005257_abnormal_intraocular_pressure1.23392740
59MP0000733_abnormal_muscle_development1.22659143
60MP0002233_abnormal_nose_morphology1.22118197
61MP0000762_abnormal_tongue_morphology1.21975630
62MP0000759_abnormal_skeletal_muscle1.20832601
63MP0005171_absent_coat_pigmentation1.20461609
64MP0001529_abnormal_vocalization1.18581846
65MP0002572_abnormal_emotion/affect_behav1.18153438
66MP0001958_emphysema1.17771731
67MP0009745_abnormal_behavioral_response1.17356690
68MP0003283_abnormal_digestive_organ1.16604468
69MP0001905_abnormal_dopamine_level1.13679008
70MP0004087_abnormal_muscle_fiber1.13306599
71MP0009250_abnormal_appendicular_skeleto1.12743709
72MP0005620_abnormal_muscle_contractility1.10675183
73MP0000747_muscle_weakness1.09063859
74MP0000569_abnormal_digit_pigmentation1.08453006
75MP0003122_maternal_imprinting1.08192352
76MP0002697_abnormal_eye_size1.07989894
77MP0000026_abnormal_inner_ear1.07002670
78MP0001486_abnormal_startle_reflex1.06295436
79MP0002557_abnormal_social/conspecific_i1.05253543
80MP0004811_abnormal_neuron_physiology1.05102464
81MP0003136_yellow_coat_color1.03092136
82MP0002067_abnormal_sensory_capabilities1.02949561
83MP0008569_lethality_at_weaning1.01294714
84MP0001177_atelectasis1.00476370
85* MP0003935_abnormal_craniofacial_develop1.00316785
86MP0000751_myopathy0.99478151
87* MP0002116_abnormal_craniofacial_bone0.99349722
88MP0000750_abnormal_muscle_regeneration0.98944286
89MP0001286_abnormal_eye_development0.98861124
90MP0001986_abnormal_taste_sensitivity0.98859811
91MP0003861_abnormal_nervous_system0.97968392
92MP0005367_renal/urinary_system_phenotyp0.97728207
93MP0000516_abnormal_urinary_system0.97728207
94MP0002064_seizures0.96900318
95MP0005275_abnormal_skin_tensile0.95754621
96MP0004270_analgesia0.94980750
97MP0003119_abnormal_digestive_system0.91572109
98MP0002282_abnormal_trachea_morphology0.91115081
99MP0004885_abnormal_endolymph0.90863903
100MP0001346_abnormal_lacrimal_gland0.88277182
101MP0002272_abnormal_nervous_system0.87597114
102MP0003937_abnormal_limbs/digits/tail_de0.87172592
103MP0002152_abnormal_brain_morphology0.83091020
104MP0000428_abnormal_craniofacial_morphol0.82724674
105MP0002735_abnormal_chemical_nociception0.80736402
106MP0004924_abnormal_behavior0.80615595
107MP0005386_behavior/neurological_phenoty0.80615595
108MP0003890_abnormal_embryonic-extraembry0.79925139
109MP0009697_abnormal_copulation0.79836796
110MP0002734_abnormal_mechanical_nocicepti0.78916836
111MP0002882_abnormal_neuron_morphology0.77698036
112MP0000678_abnormal_parathyroid_gland0.77325857
113MP0003879_abnormal_hair_cell0.76011667
114MP0004858_abnormal_nervous_system0.75515771
115MP0002733_abnormal_thermal_nociception0.75208045
116MP0002098_abnormal_vibrissa_morphology0.75093435
117MP0005174_abnormal_tail_pigmentation0.70629979
118MP0001340_abnormal_eyelid_morphology0.70365906
119MP0002081_perinatal_lethality0.69975514
120MP0002095_abnormal_skin_pigmentation0.69551925
121MP0002075_abnormal_coat/hair_pigmentati0.69537527
122MP0001186_pigmentation_phenotype0.68042310
123MP0003942_abnormal_urinary_system0.66210721
124MP0002752_abnormal_somatic_nervous0.63387566
125MP0005075_abnormal_melanosome_morpholog0.62382981
126MP0001502_abnormal_circadian_rhythm0.62143255
127MP0001970_abnormal_pain_threshold0.62092191
128MP0002114_abnormal_axial_skeleton0.62012917
129MP0000955_abnormal_spinal_cord0.61950097
130MP0009672_abnormal_birth_weight0.61350286
131MP0002932_abnormal_joint_morphology0.61079265
132MP0002127_abnormal_cardiovascular_syste0.60759044
133MP0004742_abnormal_vestibular_system0.60453434
134MP0001293_anophthalmia0.58660847
135MP0005084_abnormal_gallbladder_morpholo0.57439225

Predicted human phenotypes

RankGene SetZ-score
1Facial hemangioma (HP:0000329)7.44196255
2Hepatoblastoma (HP:0002884)6.33330577
3Abnormality of the aortic arch (HP:0012303)5.64709946
4Abnormality of the labia minora (HP:0012880)5.51725707
5Abnormality of the metopic suture (HP:0005556)5.51209687
6Abnormality of the phalanges of the hallux (HP:0010057)5.15232607
7Alacrima (HP:0000522)5.02926600
8Muscle fiber inclusion bodies (HP:0100299)4.70520064
9Decreased lacrimation (HP:0000633)4.54512108
10Long clavicles (HP:0000890)4.50446145
11Nemaline bodies (HP:0003798)4.50295158
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.45653494
13Type 1 muscle fiber predominance (HP:0003803)4.40305587
14Increased density of long bones (HP:0006392)4.36811468
15Aplasia/Hypoplasia of the sternum (HP:0006714)4.11407038
16Short 4th metacarpal (HP:0010044)4.00783484
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.00783484
18Hydroureter (HP:0000072)4.00625036
19Shallow orbits (HP:0000586)4.00173312
20Germ cell neoplasia (HP:0100728)3.80873102
21Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.79218729
22Widely patent fontanelles and sutures (HP:0004492)3.71219582
23Abnormal hair whorl (HP:0010721)3.68346547
24Adrenal hypoplasia (HP:0000835)3.57386346
25Microglossia (HP:0000171)3.54911448
26Short 1st metacarpal (HP:0010034)3.43568238
27Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.43568238
28Capillary hemangiomas (HP:0005306)3.41868406
29Natal tooth (HP:0000695)3.39518457
30Calcaneovalgus deformity (HP:0001848)3.39129646
31Abnormality of the intervertebral disk (HP:0005108)3.37898824
32Muscle hypertrophy of the lower extremities (HP:0008968)3.33156992
33Neonatal short-limb short stature (HP:0008921)3.29858010
34Distal arthrogryposis (HP:0005684)3.20095161
35Exercise-induced muscle cramps (HP:0003710)3.16714830
36Oligodactyly (HP:0012165)3.16363382
37Broad ribs (HP:0000885)3.15618835
38Wide cranial sutures (HP:0010537)3.14373159
39Deformed tarsal bones (HP:0008119)3.09690330
40Calf muscle hypertrophy (HP:0008981)3.09661448
41Hyperventilation (HP:0002883)3.05570932
42Exercise-induced myalgia (HP:0003738)2.98956785
43Embryonal neoplasm (HP:0002898)2.97067948
44Rib fusion (HP:0000902)2.96518950
45Hypoplastic labia majora (HP:0000059)2.96397642
46Abnormality of the 1st metacarpal (HP:0010009)2.91072157
47Obstructive sleep apnea (HP:0002870)2.85149573
48Opisthotonus (HP:0002179)2.79943451
49Hypoplastic nipples (HP:0002557)2.79005171
50Choanal stenosis (HP:0000452)2.77612476
51Rimmed vacuoles (HP:0003805)2.73163887
52Broad-based gait (HP:0002136)2.73024186
53Abnormal lung lobation (HP:0002101)2.69963257
54Abnormality of the calf musculature (HP:0001430)2.67136019
55Abnormality of the labia majora (HP:0012881)2.65983115
56Abnormality of the 4th metacarpal (HP:0010012)2.64300264
57Advanced eruption of teeth (HP:0006288)2.63403724
58Round ear (HP:0100830)2.59941304
59Abnormality of the ischium (HP:0003174)2.56270413
60Sleep apnea (HP:0010535)2.46900505
61Patellar aplasia (HP:0006443)2.40612576
62Abnormality of the distal phalanx of the thumb (HP:0009617)2.38055110
63Ectopic kidney (HP:0000086)2.37012257
64Abnormality of the left ventricular outflow tract (HP:0011103)2.35411433
65Subaortic stenosis (HP:0001682)2.35411433
66Focal motor seizures (HP:0011153)2.34454100
67Laryngomalacia (HP:0001601)2.32925685
68Abnormality of the diencephalon (HP:0010662)2.28713464
69Slow-growing hair (HP:0002217)2.27636405
70Abnormality of hair growth rate (HP:0011363)2.27636405
71Myotonia (HP:0002486)2.26972502
72Wrist flexion contracture (HP:0001239)2.26941992
73Protruding tongue (HP:0010808)2.24681287
74Hypoplastic ischia (HP:0003175)2.24518020
75Megalencephaly (HP:0001355)2.24515260
76Focal seizures (HP:0007359)2.22295152
77Labial hypoplasia (HP:0000066)2.21529120
78Wide anterior fontanel (HP:0000260)2.20911460
79Drooling (HP:0002307)2.20148018
80Myopathic facies (HP:0002058)2.17147459
81Aplasia/Hypoplasia of the patella (HP:0006498)2.16254818
82Heterochromia iridis (HP:0001100)2.16158911
83Midline defect of the nose (HP:0004122)2.15294442
84Septo-optic dysplasia (HP:0100842)2.14532171
85Coronal craniosynostosis (HP:0004440)2.13845985
86Muscle fiber splitting (HP:0003555)2.11807966
87Difficulty running (HP:0009046)2.10653327
88Abnormality of the pubic bones (HP:0003172)2.10330890
89Infantile muscular hypotonia (HP:0008947)2.09871171
90Frequent falls (HP:0002359)2.09186796
91Ureteral stenosis (HP:0000071)2.08929484
92Preaxial foot polydactyly (HP:0001841)2.08786622
93Bicornuate uterus (HP:0000813)2.05144196
94Epileptiform EEG discharges (HP:0011182)2.03734993
95Pachygyria (HP:0001302)2.02847491
96Hypsarrhythmia (HP:0002521)2.02637731
97Abnormality of the calcaneus (HP:0008364)2.02013601
98Absent phalangeal crease (HP:0006109)2.01196820
99Cortical dysplasia (HP:0002539)2.01196538
100Hypoplastic female external genitalia (HP:0012815)2.00640580
101Ureteral obstruction (HP:0006000)2.00257482
102Hip contracture (HP:0003273)1.99942779
103Limb-girdle muscle atrophy (HP:0003797)1.98534967
104Trigonocephaly (HP:0000243)1.98422149
105Abnormality of the hip-girdle musculature (HP:0001445)1.97617198
106Abnormality of the musculature of the pelvis (HP:0001469)1.97617198
107EEG with generalized epileptiform discharges (HP:0011198)1.97428347
108Broad hallux (HP:0010055)1.97227571
109Soft skin (HP:0000977)1.96792337
110Aplasia/Hypoplasia of the tongue (HP:0010295)1.96160388
111Asymmetry of the thorax (HP:0001555)1.95955942
112Periorbital edema (HP:0100539)1.95917630
113Protrusio acetabuli (HP:0003179)1.95833111
114Exotropia (HP:0000577)1.95470931
115Excessive salivation (HP:0003781)1.94225231
116Limb-girdle muscle weakness (HP:0003325)1.93978698
117Growth hormone deficiency (HP:0000824)1.93743201
118Renal hypoplasia (HP:0000089)1.92825710
119Cutaneous finger syndactyly (HP:0010554)1.92555155
120Scrotal hypoplasia (HP:0000046)1.91595573
121Aplasia/Hypoplasia of the nipples (HP:0006709)1.91400333
122High anterior hairline (HP:0009890)1.89212690
123Ulnar deviation of the wrist (HP:0003049)1.88607126
124Limited hip movement (HP:0008800)1.87741015
125Renal dysplasia (HP:0000110)1.86697291
126Volvulus (HP:0002580)1.85941005
127Gastroesophageal reflux (HP:0002020)1.85940737
128Shoulder girdle muscle weakness (HP:0003547)1.85531772
129Hypothermia (HP:0002045)1.85484793
130Febrile seizures (HP:0002373)1.84687974
131Split foot (HP:0001839)1.84633386
132Pheochromocytoma (HP:0002666)1.81634183
133Facial edema (HP:0000282)1.81321572
134Broad metatarsal (HP:0001783)1.80267647
135Hyperglycemia (HP:0003074)1.79908970
136Optic nerve hypoplasia (HP:0000609)1.78657351
137Long nose (HP:0003189)1.77712628
138Dandy-Walker malformation (HP:0001305)1.77685194
139Congenital diaphragmatic hernia (HP:0000776)1.77492396
140Tented upper lip vermilion (HP:0010804)1.77243275
141Aqueductal stenosis (HP:0002410)1.75861919
142Short phalanx of the thumb (HP:0009660)1.75782236
143Slender build (HP:0001533)1.73115812
144Tracheomalacia (HP:0002779)1.72086535
145Abnormal finger flexion creases (HP:0006143)1.72055744
146Type I transferrin isoform profile (HP:0003642)1.71437781
147Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71202243
148Hypoplasia of the brainstem (HP:0002365)1.71202243
149Morphological abnormality of the middle ear (HP:0008609)1.71048739
150Palpebral edema (HP:0100540)1.70392824
151Neonatal death (HP:0003811)1.69875760
152EMG: myopathic abnormalities (HP:0003458)1.69311852
153Cutis marmorata (HP:0000965)1.69213814
154Oligodactyly (hands) (HP:0001180)1.68837677
155Aplasia/Hypoplasia of the uvula (HP:0010293)1.68743804
156Abnormality of dentin (HP:0010299)1.68740657
157Postaxial foot polydactyly (HP:0001830)1.68554515
158Lissencephaly (HP:0001339)1.68328892
159Narrow nasal bridge (HP:0000446)1.67765720
160Broad toe (HP:0001837)1.66363846
161Intestinal atresia (HP:0011100)1.66315406
162Accelerated skeletal maturation (HP:0005616)1.65979382
163Embryonal renal neoplasm (HP:0011794)1.65754981
164Single transverse palmar crease (HP:0000954)1.65605274
165Nephroblastoma (Wilms tumor) (HP:0002667)1.65505519
166Cutaneous syndactyly (HP:0012725)1.64071541
167Retinal dysplasia (HP:0007973)1.61420827
168Vascular tortuosity (HP:0004948)1.61295953
169True hermaphroditism (HP:0010459)1.61136224
170Gastrointestinal atresia (HP:0002589)1.60848880
171Genu recurvatum (HP:0002816)1.60118726
172Hemiparesis (HP:0001269)1.58586673
173Synostosis involving bones of the feet (HP:0009140)1.56764373
174Synostosis involving bones of the lower limbs (HP:0009138)1.56764373
175Neuroendocrine neoplasm (HP:0100634)1.56007218
176Thin ribs (HP:0000883)1.52986311
177Anophthalmia (HP:0000528)1.52560209
178Esophageal atresia (HP:0002032)1.51527819
179Vitreoretinal degeneration (HP:0000655)1.51138658
180Atrophic scars (HP:0001075)1.50931173
181EMG: neuropathic changes (HP:0003445)1.50894715

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.79548338
2MARK14.52494599
3OBSCN3.60632611
4TNIK3.13012017
5MAP2K73.04444085
6PNCK2.96423295
7PRPF4B2.96117362
8MAPK132.56964742
9YES12.50969260
10CCNB12.38888643
11ADRBK22.31527584
12NUAK12.21128561
13SGK22.07777298
14NTRK12.07274347
15EPHA42.00351340
16TYRO31.96687219
17DYRK21.95546994
18NTRK21.94160611
19MUSK1.89729401
20MAP3K121.86442338
21TTN1.85628694
22STK38L1.84491121
23INSRR1.81213100
24BMPR1B1.76121040
25STK241.60887576
26SGK4941.58030551
27SGK2231.58030551
28PINK11.53809734
29AKT31.53628424
30EIF2AK21.53203973
31LATS11.52300091
32MAPK151.51556063
33ERBB31.50985476
34PLK21.48817129
35MKNK21.48398392
36DAPK21.46725522
37MKNK11.35432383
38MAP3K41.34952423
39EPHB21.31535339
40KSR11.30214306
41LATS21.28557459
42EPHA31.26931133
43PIM21.23525164
44CAMK41.21828431
45PDGFRA1.12820239
46CSNK1G31.11114595
47SRPK11.10820766
48SGK31.10661880
49SIK31.10140010
50UHMK11.07433780
51CSNK1G21.04289736
52RPS6KA21.03176654
53EIF2AK31.01852549
54MAP4K20.98799311
55STK160.98146395
56CAMK1G0.97925034
57MOS0.95033069
58PAK60.92963624
59BRAF0.92043488
60CSNK1A1L0.90533064
61DAPK10.89434734
62VRK10.87748665
63NTRK30.87161899
64MAP3K100.85040092
65CSNK1G10.84623782
66DDR20.83926161
67PLK40.82867595
68DYRK30.79689339
69ZAK0.78008031
70WNK30.76878742
71RPS6KA40.74988446
72NEK20.74819885
73CDK190.72910018
74KIT0.72722911
75DYRK1B0.69501897
76DYRK1A0.67375649
77GRK50.67089341
78BRD40.66610340
79ARAF0.64598756
80CDK50.63326611
81MAP3K60.62774268
82CAMK2B0.62377610
83MAP2K40.62125501
84ROCK20.61420427
85LIMK10.60335501
86BMPR20.59343051
87MYLK0.59316198
88NLK0.58042613
89PRKCZ0.57840153
90MINK10.57571747
91CDK11A0.56927516
92CDK150.56643475
93ROCK10.56319922
94ADRBK10.56165074
95CDK180.55383987
96STK110.53324272
97FGFR20.52568691
98IRAK40.51499603
99FES0.51315855
100DMPK0.51135569
101WEE10.50489747
102RPS6KL10.50475689
103RPS6KC10.50475689
104MAPK40.50214602
105CAMKK20.49875918
106MAPK120.48751170
107CAMK1D0.48061619
108CDK30.47172351
109CAMK2G0.46532786
110RPS6KA60.45869696
111PHKG10.45088499
112PHKG20.45088499
113PLK30.44848602
114PAK30.44766771
115CAMK10.43403747
116TSSK60.42680265
117TGFBR10.42657754
118PRKCG0.42507388
119CAMK2A0.42503964
120CDK140.40805913
121MARK20.40668888
122MAP3K70.40020536
123ERBB20.39561841
124WNK10.39323439
125PRKG10.39051555
126PRKCI0.38858820
127RPS6KB10.38726472
128SIK20.37653740
129PKN10.37573291
130BCR0.36627089
131CAMK2D0.35911031
132TIE10.35901097
133FGFR30.35782838
134PDGFRB0.35714751
135AKT20.35259194
136MAPK80.35054910
137MAPK70.34816139
138MAP2K10.33337109
139PRKACB0.33286045
140PRKCH0.32401535
141PRKCE0.32224632
142RPS6KA30.31886185
143CSNK1D0.31669084
144TAOK20.31193102
145PRKACA0.30156397
146PAK20.29997538

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.92437073
2Axon guidance_Homo sapiens_hsa043602.79665312
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73336832
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.53348012
5Basal cell carcinoma_Homo sapiens_hsa052172.45594793
6Dilated cardiomyopathy_Homo sapiens_hsa054142.44338657
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.34042321
8Hedgehog signaling pathway_Homo sapiens_hsa043402.32497985
9Circadian entrainment_Homo sapiens_hsa047132.26042536
10Cardiac muscle contraction_Homo sapiens_hsa042602.23737883
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.00087056
12Morphine addiction_Homo sapiens_hsa050321.94292277
13Colorectal cancer_Homo sapiens_hsa052101.89805498
14Olfactory transduction_Homo sapiens_hsa047401.85420918
15Synaptic vesicle cycle_Homo sapiens_hsa047211.83771065
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81694293
17Fanconi anemia pathway_Homo sapiens_hsa034601.76637789
18Endometrial cancer_Homo sapiens_hsa052131.76200757
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73197884
20Spliceosome_Homo sapiens_hsa030401.71815765
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66304455
22Dopaminergic synapse_Homo sapiens_hsa047281.65543202
23Serotonergic synapse_Homo sapiens_hsa047261.65173369
24Dorso-ventral axis formation_Homo sapiens_hsa043201.63104981
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.62384960
26Glutamatergic synapse_Homo sapiens_hsa047241.61727400
27GABAergic synapse_Homo sapiens_hsa047271.61197193
28Long-term potentiation_Homo sapiens_hsa047201.54291899
29Cholinergic synapse_Homo sapiens_hsa047251.47510912
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44118247
31Taste transduction_Homo sapiens_hsa047421.44085804
32Wnt signaling pathway_Homo sapiens_hsa043101.42817301
33Long-term depression_Homo sapiens_hsa047301.37299466
34Gap junction_Homo sapiens_hsa045401.34001965
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33727193
36DNA replication_Homo sapiens_hsa030301.33691143
37Base excision repair_Homo sapiens_hsa034101.33308845
38RNA degradation_Homo sapiens_hsa030181.26272936
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25886525
40Phototransduction_Homo sapiens_hsa047441.24931434
41ECM-receptor interaction_Homo sapiens_hsa045121.22192562
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20485494
43Cocaine addiction_Homo sapiens_hsa050301.19954510
44One carbon pool by folate_Homo sapiens_hsa006701.18674490
45Homologous recombination_Homo sapiens_hsa034401.18321496
46Amphetamine addiction_Homo sapiens_hsa050311.18068870
47N-Glycan biosynthesis_Homo sapiens_hsa005101.14803148
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13349122
49Estrogen signaling pathway_Homo sapiens_hsa049151.09933822
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09801221
51Focal adhesion_Homo sapiens_hsa045101.06588976
52ErbB signaling pathway_Homo sapiens_hsa040121.05828069
53Collecting duct acid secretion_Homo sapiens_hsa049661.03958463
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02320109
55Melanogenesis_Homo sapiens_hsa049161.01175146
56Calcium signaling pathway_Homo sapiens_hsa040201.00387398
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98634622
58Tight junction_Homo sapiens_hsa045300.98121106
59RNA polymerase_Homo sapiens_hsa030200.97856532
60Gastric acid secretion_Homo sapiens_hsa049710.96991850
61Adherens junction_Homo sapiens_hsa045200.96858398
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94696612
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93172473
64Renin secretion_Homo sapiens_hsa049240.91461262
65cAMP signaling pathway_Homo sapiens_hsa040240.89848867
66Glucagon signaling pathway_Homo sapiens_hsa049220.89537432
67Protein digestion and absorption_Homo sapiens_hsa049740.87370568
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83364533
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83112894
70FoxO signaling pathway_Homo sapiens_hsa040680.82480421
71Cell cycle_Homo sapiens_hsa041100.81897937
72Basal transcription factors_Homo sapiens_hsa030220.81587941
73Ras signaling pathway_Homo sapiens_hsa040140.79104313
74Vibrio cholerae infection_Homo sapiens_hsa051100.78829252
75Steroid biosynthesis_Homo sapiens_hsa001000.77600072
76Nitrogen metabolism_Homo sapiens_hsa009100.76877765
77Insulin secretion_Homo sapiens_hsa049110.76451014
78AMPK signaling pathway_Homo sapiens_hsa041520.75338717
79Purine metabolism_Homo sapiens_hsa002300.75048647
80Insulin signaling pathway_Homo sapiens_hsa049100.74416665
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74398959
82Renal cell carcinoma_Homo sapiens_hsa052110.72444892
83Nucleotide excision repair_Homo sapiens_hsa034200.70295214
84Melanoma_Homo sapiens_hsa052180.68041120
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.67774233
86Hippo signaling pathway_Homo sapiens_hsa043900.67470895
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66340603
88Glioma_Homo sapiens_hsa052140.65726994
89Mismatch repair_Homo sapiens_hsa034300.65555338
90Alcoholism_Homo sapiens_hsa050340.65460799
91Pathways in cancer_Homo sapiens_hsa052000.63932640
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63775649
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63456037
94Alzheimers disease_Homo sapiens_hsa050100.63383144
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61521916
96Prostate cancer_Homo sapiens_hsa052150.61492880
97MAPK signaling pathway_Homo sapiens_hsa040100.61320073
98Prolactin signaling pathway_Homo sapiens_hsa049170.61089106
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61023926
100Regulation of autophagy_Homo sapiens_hsa041400.60752565
101Type II diabetes mellitus_Homo sapiens_hsa049300.60559079
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.60192351
103Phagosome_Homo sapiens_hsa041450.60182400
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59854755
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59504632
106Proteasome_Homo sapiens_hsa030500.57012180
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56317610
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52202451
109Arachidonic acid metabolism_Homo sapiens_hsa005900.51834938
110MicroRNAs in cancer_Homo sapiens_hsa052060.50216111
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49159844
112Pyrimidine metabolism_Homo sapiens_hsa002400.48816287
113GnRH signaling pathway_Homo sapiens_hsa049120.48722337
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.48693716
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47590367
116Ovarian steroidogenesis_Homo sapiens_hsa049130.46666664
117Butanoate metabolism_Homo sapiens_hsa006500.45938587
118Thyroid hormone synthesis_Homo sapiens_hsa049180.45376436
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.44686823
120Oxytocin signaling pathway_Homo sapiens_hsa049210.43833133
121Salivary secretion_Homo sapiens_hsa049700.42904354
122Amoebiasis_Homo sapiens_hsa051460.42555727
123Propanoate metabolism_Homo sapiens_hsa006400.42175154
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.41927700
125Parkinsons disease_Homo sapiens_hsa050120.40164968
126Fatty acid elongation_Homo sapiens_hsa000620.39935716
127Circadian rhythm_Homo sapiens_hsa047100.38680779
128Choline metabolism in cancer_Homo sapiens_hsa052310.38567409
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38321162
130Rap1 signaling pathway_Homo sapiens_hsa040150.37606543
131Notch signaling pathway_Homo sapiens_hsa043300.36404220
132Rheumatoid arthritis_Homo sapiens_hsa053230.34363745
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34068782
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34009592
135Thyroid cancer_Homo sapiens_hsa052160.33250087
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32666621
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31977631
138TGF-beta signaling pathway_Homo sapiens_hsa043500.31371188
139Acute myeloid leukemia_Homo sapiens_hsa052210.30801789

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