

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit biogenesis (GO:0042274) | 5.15374483 |
| 2 | maturation of SSU-rRNA (GO:0030490) | 5.02431751 |
| 3 | ribosomal small subunit assembly (GO:0000028) | 4.94884957 |
| 4 | viral transcription (GO:0019083) | 4.84263368 |
| 5 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.81730762 |
| 6 | translational termination (GO:0006415) | 4.76875091 |
| 7 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.64550171 |
| 8 | DNA strand elongation (GO:0022616) | 4.55891269 |
| 9 | kinetochore organization (GO:0051383) | 4.54634045 |
| 10 | chromatin remodeling at centromere (GO:0031055) | 4.53266425 |
| 11 | CENP-A containing nucleosome assembly (GO:0034080) | 4.52698249 |
| 12 | mitotic metaphase plate congression (GO:0007080) | 4.49453881 |
| 13 | DNA replication initiation (GO:0006270) | 4.49215594 |
| 14 | DNA unwinding involved in DNA replication (GO:0006268) | 4.48176521 |
| 15 | ribosomal large subunit biogenesis (GO:0042273) | 4.47309443 |
| 16 | protein localization to kinetochore (GO:0034501) | 4.46390365 |
| 17 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.45581738 |
| 18 | translational elongation (GO:0006414) | 4.25906769 |
| 19 | DNA replication checkpoint (GO:0000076) | 4.21734353 |
| 20 | kinetochore assembly (GO:0051382) | 4.21665778 |
| 21 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.15561721 |
| 22 | formation of translation preinitiation complex (GO:0001731) | 4.13051367 |
| 23 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.08749622 |
| 24 | nucleobase biosynthetic process (GO:0046112) | 4.05837033 |
| 25 | DNA ligation (GO:0006266) | 4.03737547 |
| 26 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.02274039 |
| 27 | ATP synthesis coupled proton transport (GO:0015986) | 4.02274039 |
| 28 | translational initiation (GO:0006413) | 4.02209581 |
| 29 | metaphase plate congression (GO:0051310) | 4.01100818 |
| 30 | telomere maintenance via recombination (GO:0000722) | 3.98557214 |
| 31 | DNA replication-independent nucleosome organization (GO:0034724) | 3.98165120 |
| 32 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.98165120 |
| 33 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.96674743 |
| 34 | chaperone-mediated protein transport (GO:0072321) | 3.94944514 |
| 35 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.94250794 |
| 36 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.92555241 |
| 37 | mitotic recombination (GO:0006312) | 3.87961051 |
| 38 | protein localization to chromosome, centromeric region (GO:0071459) | 3.86286170 |
| 39 | cotranslational protein targeting to membrane (GO:0006613) | 3.85117230 |
| 40 | purine nucleobase biosynthetic process (GO:0009113) | 3.84433733 |
| 41 | mitotic nuclear envelope disassembly (GO:0007077) | 3.84129419 |
| 42 | protein targeting to ER (GO:0045047) | 3.83129004 |
| 43 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.79153247 |
| 44 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.79153247 |
| 45 | histone exchange (GO:0043486) | 3.78372439 |
| 46 | telomere maintenance via telomere lengthening (GO:0010833) | 3.75909596 |
| 47 | cellular protein complex disassembly (GO:0043624) | 3.75575946 |
| 48 | establishment of integrated proviral latency (GO:0075713) | 3.71851044 |
| 49 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.71237203 |
| 50 | viral life cycle (GO:0019058) | 3.68801109 |
| 51 | DNA deamination (GO:0045006) | 3.66834246 |
| 52 | mitotic chromosome condensation (GO:0007076) | 3.66708436 |
| 53 | nuclear pore organization (GO:0006999) | 3.66433679 |
| 54 | mitotic sister chromatid segregation (GO:0000070) | 3.64658637 |
| 55 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.62396617 |
| 56 | establishment of chromosome localization (GO:0051303) | 3.61594175 |
| 57 | protein localization to endoplasmic reticulum (GO:0070972) | 3.58795442 |
| 58 | IMP biosynthetic process (GO:0006188) | 3.58434799 |
| 59 | ribosome biogenesis (GO:0042254) | 3.55600841 |
| 60 | nuclear envelope disassembly (GO:0051081) | 3.53449126 |
| 61 | membrane disassembly (GO:0030397) | 3.53449126 |
| 62 | rRNA processing (GO:0006364) | 3.52381855 |
| 63 | meiotic chromosome segregation (GO:0045132) | 3.51260203 |
| 64 | ribosome assembly (GO:0042255) | 3.48689473 |
| 65 | spliceosomal snRNP assembly (GO:0000387) | 3.42579215 |
| 66 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.41511760 |
| 67 | rRNA metabolic process (GO:0016072) | 3.39302840 |
| 68 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.39200986 |
| 69 | protein complex disassembly (GO:0043241) | 3.38475285 |
| 70 | mitotic spindle checkpoint (GO:0071174) | 3.38434413 |
| 71 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.37101761 |
| 72 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.35035629 |
| 73 | regulation of spindle organization (GO:0090224) | 3.32241388 |
| 74 | nuclear pore complex assembly (GO:0051292) | 3.30954985 |
| 75 | establishment of viral latency (GO:0019043) | 3.30894555 |
| 76 | regulation of mitochondrial translation (GO:0070129) | 3.30884717 |
| 77 | mitotic spindle assembly checkpoint (GO:0007094) | 3.28225524 |
| 78 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.28208207 |
| 79 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.27980845 |
| 80 | rRNA modification (GO:0000154) | 3.26782095 |
| 81 | IMP metabolic process (GO:0046040) | 3.26082698 |
| 82 | sister chromatid segregation (GO:0000819) | 3.25655038 |
| 83 | regulation of centriole replication (GO:0046599) | 3.24769704 |
| 84 | centriole replication (GO:0007099) | 3.23148336 |
| 85 | DNA topological change (GO:0006265) | 3.22420125 |
| 86 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.22167953 |
| 87 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.22167953 |
| 88 | regulation of sister chromatid segregation (GO:0033045) | 3.22167953 |
| 89 | chromosome segregation (GO:0007059) | 3.21032834 |
| 90 | macromolecular complex disassembly (GO:0032984) | 3.19932976 |
| 91 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.19114059 |
| 92 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.19017957 |
| 93 | translation (GO:0006412) | 3.17269533 |
| 94 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.15900625 |
| 95 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.15900625 |
| 96 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.15587489 |
| 97 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.15467439 |
| 98 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.14180698 |
| 99 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.13433059 |
| 100 | replication fork processing (GO:0031297) | 3.10928360 |
| 101 | respiratory electron transport chain (GO:0022904) | 3.10847520 |
| 102 | mitotic G2/M transition checkpoint (GO:0044818) | 3.09543314 |
| 103 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.08786776 |
| 104 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.08786776 |
| 105 | chromatin assembly or disassembly (GO:0006333) | 3.07427371 |
| 106 | protein K6-linked ubiquitination (GO:0085020) | 3.07250857 |
| 107 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.06490498 |
| 108 | negative regulation of ligase activity (GO:0051352) | 3.06490498 |
| 109 | DNA geometric change (GO:0032392) | 3.04404954 |
| 110 | DNA duplex unwinding (GO:0032508) | 3.03778124 |
| 111 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.02965594 |
| 112 | cellular component biogenesis (GO:0044085) | 3.02665711 |
| 113 | spindle checkpoint (GO:0031577) | 3.02020553 |
| 114 | negative regulation of chromosome segregation (GO:0051985) | 3.01717062 |
| 115 | proteasome assembly (GO:0043248) | 3.01484274 |
| 116 | pseudouridine synthesis (GO:0001522) | 3.00663326 |
| 117 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.99289225 |
| 118 | negative regulation of sister chromatid segregation (GO:0033046) | 2.99289225 |
| 119 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.99289225 |
| 120 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.99289225 |
| 121 | mRNA catabolic process (GO:0006402) | 2.98414896 |
| 122 | spliceosomal complex assembly (GO:0000245) | 2.98399892 |
| 123 | folic acid metabolic process (GO:0046655) | 2.95372726 |
| 124 | RNA catabolic process (GO:0006401) | 2.93757525 |
| 125 | spindle assembly checkpoint (GO:0071173) | 2.92885856 |
| 126 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.91694705 |
| 127 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.90290141 |
| 128 | regulation of chromosome segregation (GO:0051983) | 2.90284375 |
| 129 | positive regulation of chromosome segregation (GO:0051984) | 2.88938591 |
| 130 | regulation of mitotic spindle organization (GO:0060236) | 2.88348800 |
| 131 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.88323113 |
| 132 | ATP-dependent chromatin remodeling (GO:0043044) | 2.88117803 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.51919733 |
| 2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.59593777 |
| 3 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.25517478 |
| 4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.86187946 |
| 5 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.59230737 |
| 6 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.43345222 |
| 7 | * KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.21979737 |
| 8 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.20532953 |
| 9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.01991450 |
| 10 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.94087730 |
| 11 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.88105167 |
| 12 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.74575926 |
| 13 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.67985939 |
| 14 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.63938222 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.58785757 |
| 16 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.47807277 |
| 17 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.44207443 |
| 18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.42858047 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.39974424 |
| 20 | * AR_21909140_ChIP-Seq_LNCAP_Human | 2.18529996 |
| 21 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.14869677 |
| 22 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.12932624 |
| 23 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.08691270 |
| 24 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.03649195 |
| 25 | * E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.98112051 |
| 26 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.98108090 |
| 27 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.95910905 |
| 28 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.94419966 |
| 29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.88874866 |
| 30 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.87010343 |
| 31 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.84960828 |
| 32 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.84211211 |
| 33 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.83465161 |
| 34 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.77189084 |
| 35 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.75509308 |
| 36 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.68489053 |
| 37 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.68146777 |
| 38 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.67602703 |
| 39 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.67204152 |
| 40 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.62958897 |
| 41 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.62184120 |
| 42 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.58639128 |
| 43 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.55943793 |
| 44 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.55565884 |
| 45 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.52378561 |
| 46 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.51422578 |
| 47 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.50928115 |
| 48 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.48790333 |
| 49 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.48475799 |
| 50 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.45039554 |
| 51 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.43881908 |
| 52 | * SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.42771464 |
| 53 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.39820639 |
| 54 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.39583923 |
| 55 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.38048069 |
| 56 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.33880472 |
| 57 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.33340360 |
| 58 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.31734810 |
| 59 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.31603749 |
| 60 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.28228235 |
| 61 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.26288713 |
| 62 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.24538074 |
| 63 | EWS_26573619_Chip-Seq_HEK293_Human | 1.22482515 |
| 64 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.21584192 |
| 65 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.19307723 |
| 66 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.18699600 |
| 67 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.18351564 |
| 68 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.18120699 |
| 69 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.17624432 |
| 70 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.16942422 |
| 71 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.15134334 |
| 72 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.14995438 |
| 73 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.14995438 |
| 74 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.14995438 |
| 75 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.14110510 |
| 76 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.10169574 |
| 77 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.09866284 |
| 78 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.09573050 |
| 79 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.07031263 |
| 80 | MYC_22102868_ChIP-Seq_BL_Human | 1.06887785 |
| 81 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.05220089 |
| 82 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.04732994 |
| 83 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.04217481 |
| 84 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.03129078 |
| 85 | FUS_26573619_Chip-Seq_HEK293_Human | 1.02502738 |
| 86 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.01266238 |
| 87 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.98338019 |
| 88 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.97766150 |
| 89 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.96784063 |
| 90 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.95945140 |
| 91 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.95640608 |
| 92 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.95638028 |
| 93 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.95123842 |
| 94 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.93411614 |
| 95 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.91394864 |
| 96 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.91098928 |
| 97 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.89328806 |
| 98 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.89296826 |
| 99 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.88817722 |
| 100 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.87019851 |
| 101 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.86246892 |
| 102 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.85992060 |
| 103 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.85926939 |
| 104 | VDR_22108803_ChIP-Seq_LS180_Human | 0.85142064 |
| 105 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.84341463 |
| 106 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.83980434 |
| 107 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.83097713 |
| 108 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.81524948 |
| 109 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.81221561 |
| 110 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.79503374 |
| 111 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.78341951 |
| 112 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.77033015 |
| 113 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.75571036 |
| 114 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.70592325 |
| 115 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.61925316 |
| 116 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.58441879 |
| 117 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.55536282 |
| 118 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.55440121 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.70401441 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.71459401 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.51742414 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.26259423 |
| 5 | MP0003077_abnormal_cell_cycle | 4.01700929 |
| 6 | MP0008057_abnormal_DNA_replication | 3.94281314 |
| 7 | MP0008058_abnormal_DNA_repair | 3.40491649 |
| 8 | MP0003806_abnormal_nucleotide_metabolis | 3.00941752 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.79904153 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.74759514 |
| 11 | MP0003123_paternal_imprinting | 2.69065271 |
| 12 | MP0001730_embryonic_growth_arrest | 2.44533700 |
| 13 | MP0010352_gastrointestinal_tract_polyps | 2.28183512 |
| 14 | MP0003136_yellow_coat_color | 2.23701656 |
| 15 | MP0000350_abnormal_cell_proliferation | 2.17486680 |
| 16 | MP0002938_white_spotting | 2.15584439 |
| 17 | MP0008877_abnormal_DNA_methylation | 2.08171241 |
| 18 | MP0009379_abnormal_foot_pigmentation | 2.05198834 |
| 19 | MP0003786_premature_aging | 1.97539161 |
| 20 | MP0003890_abnormal_embryonic-extraembry | 1.86227825 |
| 21 | MP0003718_maternal_effect | 1.84924386 |
| 22 | MP0005380_embryogenesis_phenotype | 1.76343724 |
| 23 | MP0001672_abnormal_embryogenesis/_devel | 1.76343724 |
| 24 | MP0004133_heterotaxia | 1.75814743 |
| 25 | MP0010030_abnormal_orbit_morphology | 1.75382374 |
| 26 | MP0002396_abnormal_hematopoietic_system | 1.75004166 |
| 27 | MP0001697_abnormal_embryo_size | 1.68928423 |
| 28 | MP0001529_abnormal_vocalization | 1.62579254 |
| 29 | MP0002085_abnormal_embryonic_tissue | 1.56457294 |
| 30 | MP0003186_abnormal_redox_activity | 1.54984636 |
| 31 | MP0002080_prenatal_lethality | 1.54783729 |
| 32 | MP0003984_embryonic_growth_retardation | 1.53548465 |
| 33 | MP0002088_abnormal_embryonic_growth/wei | 1.49740813 |
| 34 | MP0006072_abnormal_retinal_apoptosis | 1.47768022 |
| 35 | MP0002084_abnormal_developmental_patter | 1.45417850 |
| 36 | MP0000490_abnormal_crypts_of | 1.44806094 |
| 37 | MP0010307_abnormal_tumor_latency | 1.42096656 |
| 38 | MP0003941_abnormal_skin_development | 1.40958383 |
| 39 | MP0002086_abnormal_extraembryonic_tissu | 1.38044660 |
| 40 | MP0009053_abnormal_anal_canal | 1.37582455 |
| 41 | MP0000313_abnormal_cell_death | 1.35953721 |
| 42 | MP0002019_abnormal_tumor_incidence | 1.34173571 |
| 43 | MP0002210_abnormal_sex_determination | 1.32044861 |
| 44 | MP0008995_early_reproductive_senescence | 1.31339318 |
| 45 | MP0004197_abnormal_fetal_growth/weight/ | 1.31251049 |
| 46 | MP0003567_abnormal_fetal_cardiomyocyte | 1.29867699 |
| 47 | MP0006292_abnormal_olfactory_placode | 1.29569777 |
| 48 | MP0002234_abnormal_pharynx_morphology | 1.27137427 |
| 49 | MP0001293_anophthalmia | 1.24894536 |
| 50 | MP0005499_abnormal_olfactory_system | 1.23160307 |
| 51 | MP0005394_taste/olfaction_phenotype | 1.23160307 |
| 52 | MP0004147_increased_porphyrin_level | 1.16009027 |
| 53 | MP0003705_abnormal_hypodermis_morpholog | 1.14864519 |
| 54 | MP0001145_abnormal_male_reproductive | 1.13491300 |
| 55 | MP0000049_abnormal_middle_ear | 1.12393524 |
| 56 | MP0000372_irregular_coat_pigmentation | 1.10862268 |
| 57 | MP0003119_abnormal_digestive_system | 1.06520036 |
| 58 | MP0002233_abnormal_nose_morphology | 1.06261580 |
| 59 | MP0002102_abnormal_ear_morphology | 1.04358609 |
| 60 | MP0000566_synostosis | 1.04224022 |
| 61 | MP0000653_abnormal_sex_gland | 1.01193495 |
| 62 | MP0001929_abnormal_gametogenesis | 0.99370658 |
| 63 | MP0002837_dystrophic_cardiac_calcinosis | 0.99142899 |
| 64 | MP0003121_genomic_imprinting | 0.95474299 |
| 65 | MP0006036_abnormal_mitochondrial_physio | 0.94180403 |
| 66 | MP0004808_abnormal_hematopoietic_stem | 0.93841066 |
| 67 | MP0002111_abnormal_tail_morphology | 0.92622800 |
| 68 | MP0005266_abnormal_metabolism | 0.92470800 |
| 69 | MP0001346_abnormal_lacrimal_gland | 0.92066021 |
| 70 | MP0002095_abnormal_skin_pigmentation | 0.91798785 |
| 71 | MP0003698_abnormal_male_reproductive | 0.91114473 |
| 72 | MP0003315_abnormal_perineum_morphology | 0.89853244 |
| 73 | MP0001119_abnormal_female_reproductive | 0.86670228 |
| 74 | MP0005023_abnormal_wound_healing | 0.86199383 |
| 75 | MP0001286_abnormal_eye_development | 0.85655149 |
| 76 | MP0000631_abnormal_neuroendocrine_gland | 0.85253509 |
| 77 | MP0005076_abnormal_cell_differentiation | 0.81716639 |
| 78 | MP0002160_abnormal_reproductive_system | 0.80795838 |
| 79 | MP0002132_abnormal_respiratory_system | 0.79669652 |
| 80 | MP0005501_abnormal_skin_physiology | 0.79480380 |
| 81 | MP0001915_intracranial_hemorrhage | 0.79397961 |
| 82 | MP0009672_abnormal_birth_weight | 0.78794503 |
| 83 | MP0000358_abnormal_cell_content/ | 0.76844555 |
| 84 | MP0001545_abnormal_hematopoietic_system | 0.75780715 |
| 85 | MP0005397_hematopoietic_system_phenotyp | 0.75780715 |
| 86 | MP0002163_abnormal_gland_morphology | 0.75552524 |
| 87 | MP0003566_abnormal_cell_adhesion | 0.74934848 |
| 88 | MP0001853_heart_inflammation | 0.74590570 |
| 89 | MP0000858_altered_metastatic_potential | 0.74406460 |
| 90 | MP0005389_reproductive_system_phenotype | 0.73862177 |
| 91 | MP0005084_abnormal_gallbladder_morpholo | 0.72903243 |
| 92 | MP0005391_vision/eye_phenotype | 0.72332002 |
| 93 | MP0002161_abnormal_fertility/fecundity | 0.72150992 |
| 94 | MP0003938_abnormal_ear_development | 0.71399455 |
| 95 | MP0003861_abnormal_nervous_system | 0.71316492 |
| 96 | MP0008789_abnormal_olfactory_epithelium | 0.70479187 |
| 97 | MP0001764_abnormal_homeostasis | 0.70338293 |
| 98 | MP0003755_abnormal_palate_morphology | 0.70141653 |
| 99 | MP0000703_abnormal_thymus_morphology | 0.69199539 |
| 100 | MP0005171_absent_coat_pigmentation | 0.67861657 |
| 101 | MP0003937_abnormal_limbs/digits/tail_de | 0.67855119 |
| 102 | MP0001919_abnormal_reproductive_system | 0.67015669 |
| 103 | MP0002653_abnormal_ependyma_morphology | 0.66735029 |
| 104 | MP0001485_abnormal_pinna_reflex | 0.66686532 |
| 105 | MP0009697_abnormal_copulation | 0.65096655 |
| 106 | MP0002736_abnormal_nociception_after | 0.64151158 |
| 107 | MP0001849_ear_inflammation | 0.63391873 |
| 108 | MP0005384_cellular_phenotype | 0.61793135 |
| 109 | MP0002751_abnormal_autonomic_nervous | 0.61671008 |
| 110 | MP0005253_abnormal_eye_physiology | 0.61293180 |
| 111 | MP0002722_abnormal_immune_system | 0.60616967 |
| 112 | MP0005408_hypopigmentation | 0.60575537 |
| 113 | MP0005085_abnormal_gallbladder_physiolo | 0.59348192 |
| 114 | MP0005360_urolithiasis | 0.58331019 |
| 115 | MP0005174_abnormal_tail_pigmentation | 0.57050759 |
| 116 | MP0005075_abnormal_melanosome_morpholog | 0.57040601 |
| 117 | MP0009333_abnormal_splenocyte_physiolog | 0.56792148 |
| 118 | MP0003699_abnormal_female_reproductive | 0.56690555 |
| 119 | MP0002249_abnormal_larynx_morphology | 0.56626257 |
| 120 | MP0004264_abnormal_extraembryonic_tissu | 0.56417627 |
| 121 | MP0000689_abnormal_spleen_morphology | 0.56060806 |
| 122 | MP0002092_abnormal_eye_morphology | 0.55702447 |
| 123 | MP0005395_other_phenotype | 0.55436175 |
| 124 | MP0000432_abnormal_head_morphology | 0.55280360 |
| 125 | MP0000477_abnormal_intestine_morphology | 0.54776706 |
| 126 | MP0002697_abnormal_eye_size | 0.54580871 |
| 127 | MP0003385_abnormal_body_wall | 0.54539126 |
| 128 | MP0005621_abnormal_cell_physiology | 0.54027252 |
| 129 | MP0003763_abnormal_thymus_physiology | 0.53920654 |
| 130 | MP0006035_abnormal_mitochondrial_morpho | 0.53580401 |
| 131 | MP0009703_decreased_birth_body | 0.53083468 |
| 132 | MP0002139_abnormal_hepatobiliary_system | 0.52693142 |
| 133 | MP0000598_abnormal_liver_morphology | 0.52376467 |
| 134 | MP0000537_abnormal_urethra_morphology | 0.52148506 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 5.31753457 |
| 2 | Reticulocytopenia (HP:0001896) | 5.11816907 |
| 3 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.08405560 |
| 4 | Abnormal number of erythroid precursors (HP:0012131) | 4.64240763 |
| 5 | Acute necrotizing encephalopathy (HP:0006965) | 4.12078098 |
| 6 | Colon cancer (HP:0003003) | 4.04411108 |
| 7 | Oral leukoplakia (HP:0002745) | 3.98786756 |
| 8 | Breast hypoplasia (HP:0003187) | 3.94376840 |
| 9 | Acute encephalopathy (HP:0006846) | 3.77754292 |
| 10 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.70251753 |
| 11 | Macrocytic anemia (HP:0001972) | 3.62415094 |
| 12 | Chromsome breakage (HP:0040012) | 3.58292666 |
| 13 | Aplastic anemia (HP:0001915) | 3.50683821 |
| 14 | Selective tooth agenesis (HP:0001592) | 3.50595347 |
| 15 | Increased hepatocellular lipid droplets (HP:0006565) | 3.41148580 |
| 16 | Mitochondrial inheritance (HP:0001427) | 3.36091451 |
| 17 | Progressive macrocephaly (HP:0004481) | 3.31208658 |
| 18 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.25304942 |
| 19 | Increased CSF lactate (HP:0002490) | 3.24336455 |
| 20 | Absent thumb (HP:0009777) | 3.12731514 |
| 21 | Patellar aplasia (HP:0006443) | 3.11929726 |
| 22 | Pallor (HP:0000980) | 3.10097097 |
| 23 | Medulloblastoma (HP:0002885) | 3.08143190 |
| 24 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.05792506 |
| 25 | Lipid accumulation in hepatocytes (HP:0006561) | 3.00856112 |
| 26 | Ependymoma (HP:0002888) | 2.94370256 |
| 27 | Hepatocellular necrosis (HP:0001404) | 2.89645716 |
| 28 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.87155187 |
| 29 | Abnormality of the preputium (HP:0100587) | 2.83994966 |
| 30 | Abnormality of the anterior horn cell (HP:0006802) | 2.81811887 |
| 31 | Degeneration of anterior horn cells (HP:0002398) | 2.81811887 |
| 32 | Cerebral edema (HP:0002181) | 2.81693262 |
| 33 | Abnormality of chromosome stability (HP:0003220) | 2.79109234 |
| 34 | Multiple enchondromatosis (HP:0005701) | 2.78809695 |
| 35 | Meckel diverticulum (HP:0002245) | 2.78117824 |
| 36 | Rhabdomyosarcoma (HP:0002859) | 2.77934206 |
| 37 | Carpal bone hypoplasia (HP:0001498) | 2.74427645 |
| 38 | Rough bone trabeculation (HP:0100670) | 2.71406867 |
| 39 | Impulsivity (HP:0100710) | 2.71340576 |
| 40 | Hepatic necrosis (HP:0002605) | 2.67868268 |
| 41 | Septo-optic dysplasia (HP:0100842) | 2.64902520 |
| 42 | Absent radius (HP:0003974) | 2.64534038 |
| 43 | 11 pairs of ribs (HP:0000878) | 2.63314101 |
| 44 | Abnormality of the ileum (HP:0001549) | 2.62605662 |
| 45 | Supernumerary spleens (HP:0009799) | 2.58366393 |
| 46 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.54739723 |
| 47 | Agnosia (HP:0010524) | 2.54418481 |
| 48 | Trismus (HP:0000211) | 2.51789217 |
| 49 | Abnormality of the carotid arteries (HP:0005344) | 2.50155930 |
| 50 | Abnormal hemoglobin (HP:0011902) | 2.47753910 |
| 51 | Abnormal lung lobation (HP:0002101) | 2.46887014 |
| 52 | Myelodysplasia (HP:0002863) | 2.45083934 |
| 53 | Aplasia involving forearm bones (HP:0009822) | 2.44236504 |
| 54 | Absent forearm bone (HP:0003953) | 2.44236504 |
| 55 | Microvesicular hepatic steatosis (HP:0001414) | 2.44217215 |
| 56 | Small intestinal stenosis (HP:0012848) | 2.42603082 |
| 57 | Duodenal stenosis (HP:0100867) | 2.42603082 |
| 58 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.38848562 |
| 59 | Neoplasm of the pancreas (HP:0002894) | 2.38092164 |
| 60 | Microretrognathia (HP:0000308) | 2.36901478 |
| 61 | Horseshoe kidney (HP:0000085) | 2.36856348 |
| 62 | Cellular immunodeficiency (HP:0005374) | 2.36734551 |
| 63 | Renal Fanconi syndrome (HP:0001994) | 2.35678137 |
| 64 | Abnormal number of incisors (HP:0011064) | 2.34616567 |
| 65 | Atresia of the external auditory canal (HP:0000413) | 2.34266148 |
| 66 | Stenosis of the external auditory canal (HP:0000402) | 2.33306897 |
| 67 | Abnormality of abdominal situs (HP:0011620) | 2.31666935 |
| 68 | Abdominal situs inversus (HP:0003363) | 2.31666935 |
| 69 | Abnormality of the labia minora (HP:0012880) | 2.30831796 |
| 70 | Increased serum lactate (HP:0002151) | 2.30334350 |
| 71 | Missing ribs (HP:0000921) | 2.29462919 |
| 72 | Clubbing of toes (HP:0100760) | 2.29025214 |
| 73 | Volvulus (HP:0002580) | 2.24384648 |
| 74 | Abnormality of reticulocytes (HP:0004312) | 2.18628794 |
| 75 | Duplicated collecting system (HP:0000081) | 2.17932445 |
| 76 | Hyperglycinemia (HP:0002154) | 2.17527896 |
| 77 | Leukodystrophy (HP:0002415) | 2.16928611 |
| 78 | Bone marrow hypocellularity (HP:0005528) | 2.16769657 |
| 79 | Premature graying of hair (HP:0002216) | 2.16134800 |
| 80 | Sloping forehead (HP:0000340) | 2.15860053 |
| 81 | Triphalangeal thumb (HP:0001199) | 2.15838443 |
| 82 | Premature ovarian failure (HP:0008209) | 2.15131270 |
| 83 | Tracheoesophageal fistula (HP:0002575) | 2.14429729 |
| 84 | Cleft eyelid (HP:0000625) | 2.13858282 |
| 85 | Respiratory difficulties (HP:0002880) | 2.13247259 |
| 86 | Pancytopenia (HP:0001876) | 2.12795679 |
| 87 | Neoplasm of the colon (HP:0100273) | 2.12190494 |
| 88 | Embryonal renal neoplasm (HP:0011794) | 2.11021356 |
| 89 | 3-Methylglutaconic aciduria (HP:0003535) | 2.09753327 |
| 90 | Hypoplastic pelvis (HP:0008839) | 2.08227407 |
| 91 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.07508320 |
| 92 | Absent septum pellucidum (HP:0001331) | 2.07101331 |
| 93 | Abnormality of the duodenum (HP:0002246) | 2.06366427 |
| 94 | Basal cell carcinoma (HP:0002671) | 2.06145553 |
| 95 | Lactic acidosis (HP:0003128) | 2.05686670 |
| 96 | Hypoplasia of the pons (HP:0012110) | 2.05658571 |
| 97 | Glossoptosis (HP:0000162) | 2.05345485 |
| 98 | Abnormality of the renal collecting system (HP:0004742) | 2.00521069 |
| 99 | Rib fusion (HP:0000902) | 2.00286121 |
| 100 | Congenital, generalized hypertrichosis (HP:0004540) | 1.99442114 |
| 101 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.96753741 |
| 102 | Exercise intolerance (HP:0003546) | 1.96624239 |
| 103 | Sparse eyelashes (HP:0000653) | 1.95803855 |
| 104 | Abnormality of the pons (HP:0007361) | 1.95515408 |
| 105 | Respiratory failure (HP:0002878) | 1.95175312 |
| 106 | Exertional dyspnea (HP:0002875) | 1.94263978 |
| 107 | Asplenia (HP:0001746) | 1.94042600 |
| 108 | Increased intramyocellular lipid droplets (HP:0012240) | 1.93710680 |
| 109 | Abnormality of cochlea (HP:0000375) | 1.93438799 |
| 110 | Secondary amenorrhea (HP:0000869) | 1.93263235 |
| 111 | Increased serum pyruvate (HP:0003542) | 1.91855296 |
| 112 | Cerebral hypomyelination (HP:0006808) | 1.90795471 |
| 113 | Abnormality of the septum pellucidum (HP:0007375) | 1.90603952 |
| 114 | Neoplasm of striated muscle (HP:0009728) | 1.90181593 |
| 115 | Abnormal trabecular bone morphology (HP:0100671) | 1.89563097 |
| 116 | Methylmalonic acidemia (HP:0002912) | 1.89401497 |
| 117 | Duplication of thumb phalanx (HP:0009942) | 1.88441633 |
| 118 | Facial cleft (HP:0002006) | 1.87534133 |
| 119 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.84954257 |
| 120 | Neoplasm of the oral cavity (HP:0100649) | 1.84709866 |
| 121 | Megaloblastic anemia (HP:0001889) | 1.84292792 |
| 122 | Nausea (HP:0002018) | 1.84030758 |
| 123 | Pancreatic cysts (HP:0001737) | 1.83868034 |
| 124 | Abnormality of methionine metabolism (HP:0010901) | 1.82355469 |
| 125 | Biliary tract neoplasm (HP:0100574) | 1.82170677 |
| 126 | Thrombocytosis (HP:0001894) | 1.82053904 |
| 127 | Short thumb (HP:0009778) | 1.81577679 |
| 128 | Deviation of the thumb (HP:0009603) | 1.81178287 |
| 129 | Type I transferrin isoform profile (HP:0003642) | 1.81125274 |
| 130 | Hypoplasia of the radius (HP:0002984) | 1.80608483 |
| 131 | Ovarian neoplasm (HP:0100615) | 1.80556157 |
| 132 | Proximal placement of thumb (HP:0009623) | 1.80498009 |
| 133 | Squamous cell carcinoma (HP:0002860) | 1.79451464 |
| 134 | Pancreatic fibrosis (HP:0100732) | 1.78951293 |
| 135 | Abnormality of glycolysis (HP:0004366) | 1.78788342 |
| 136 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 1.78736503 |
| 137 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.77952029 |
| 138 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.77443172 |
| 139 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.77443172 |
| 140 | Amaurosis fugax (HP:0100576) | 1.77398500 |
| 141 | Increased nuchal translucency (HP:0010880) | 1.75713226 |
| 142 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.74353230 |
| 143 | Ectopic kidney (HP:0000086) | 1.73001578 |
| 144 | Pendular nystagmus (HP:0012043) | 1.72193456 |
| 145 | Oligodactyly (hands) (HP:0001180) | 1.70508294 |
| 146 | Optic disc pallor (HP:0000543) | 1.69064962 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 4.60233812 |
| 2 | BUB1 | 4.47390608 |
| 3 | WEE1 | 4.40464677 |
| 4 | VRK2 | 4.23469590 |
| 5 | EIF2AK1 | 3.57927811 |
| 6 | NEK1 | 2.95499527 |
| 7 | NEK2 | 2.75292901 |
| 8 | TTK | 2.65014315 |
| 9 | NME2 | 2.43469222 |
| 10 | TAF1 | 2.34671838 |
| 11 | BRSK2 | 2.34413041 |
| 12 | VRK1 | 2.27076347 |
| 13 | PLK4 | 2.26873682 |
| 14 | PLK1 | 2.13277244 |
| 15 | SRPK1 | 2.11252826 |
| 16 | RPS6KB2 | 2.09692215 |
| 17 | ACVR1B | 2.08162725 |
| 18 | CDK7 | 1.96481658 |
| 19 | TLK1 | 1.91185647 |
| 20 | AURKB | 1.89162038 |
| 21 | EIF2AK3 | 1.74250702 |
| 22 | ATR | 1.62005148 |
| 23 | PLK3 | 1.60490180 |
| 24 | NUAK1 | 1.60257631 |
| 25 | TESK2 | 1.57437212 |
| 26 | DYRK3 | 1.49220494 |
| 27 | TSSK6 | 1.47898885 |
| 28 | PASK | 1.46914989 |
| 29 | BRSK1 | 1.44892983 |
| 30 | CHEK2 | 1.44654875 |
| 31 | STK16 | 1.44389156 |
| 32 | MAP3K8 | 1.42863867 |
| 33 | AURKA | 1.40551088 |
| 34 | MKNK1 | 1.36176884 |
| 35 | CDK12 | 1.34378920 |
| 36 | STK10 | 1.33757526 |
| 37 | PBK | 1.28220532 |
| 38 | EPHA2 | 1.25542674 |
| 39 | CHEK1 | 1.24645632 |
| 40 | RPS6KA4 | 1.23905931 |
| 41 | CDK4 | 1.23852373 |
| 42 | TNIK | 1.20590007 |
| 43 | BCKDK | 1.19494683 |
| 44 | STK4 | 1.16580275 |
| 45 | SCYL2 | 1.13781691 |
| 46 | TRIM28 | 1.12751995 |
| 47 | TGFBR1 | 1.12133841 |
| 48 | BMPR1B | 1.11051306 |
| 49 | WNK3 | 1.10191174 |
| 50 | CCNB1 | 1.06669225 |
| 51 | MAPKAPK3 | 1.00846598 |
| 52 | MAP3K11 | 0.99885565 |
| 53 | EEF2K | 0.98063516 |
| 54 | PAK4 | 0.95897151 |
| 55 | LRRK2 | 0.90357842 |
| 56 | ATM | 0.89916401 |
| 57 | CDK6 | 0.89898821 |
| 58 | FLT3 | 0.89570987 |
| 59 | CDK19 | 0.88295149 |
| 60 | BRAF | 0.87705488 |
| 61 | ZAK | 0.84644611 |
| 62 | CDK2 | 0.83223268 |
| 63 | PDK2 | 0.82698474 |
| 64 | STK38L | 0.82026396 |
| 65 | MKNK2 | 0.80780765 |
| 66 | MAP3K10 | 0.79194796 |
| 67 | CSNK2A2 | 0.78814034 |
| 68 | MAP2K3 | 0.76969881 |
| 69 | EIF2AK2 | 0.76440919 |
| 70 | CSNK2A1 | 0.73675369 |
| 71 | PIM1 | 0.73205398 |
| 72 | TESK1 | 0.73169107 |
| 73 | PAK1 | 0.68982136 |
| 74 | CDK8 | 0.68040868 |
| 75 | MELK | 0.63331653 |
| 76 | CDK1 | 0.63154230 |
| 77 | ALK | 0.61246824 |
| 78 | MAP3K3 | 0.60392554 |
| 79 | PRKCI | 0.60136674 |
| 80 | LATS2 | 0.59892015 |
| 81 | PLK2 | 0.59366339 |
| 82 | MST4 | 0.57287482 |
| 83 | PDK4 | 0.57228661 |
| 84 | PDK3 | 0.57228661 |
| 85 | PKN2 | 0.53360221 |
| 86 | MAP3K4 | 0.50635854 |
| 87 | TAOK2 | 0.46378089 |
| 88 | KDR | 0.45502666 |
| 89 | CLK1 | 0.44943797 |
| 90 | ABL2 | 0.44306325 |
| 91 | MAP4K1 | 0.43151991 |
| 92 | BRD4 | 0.43097289 |
| 93 | PIM2 | 0.42115459 |
| 94 | NME1 | 0.40505510 |
| 95 | CSNK1E | 0.39767950 |
| 96 | DYRK2 | 0.39153882 |
| 97 | CDK3 | 0.37120623 |
| 98 | RPS6KA5 | 0.36980929 |
| 99 | CSNK1G1 | 0.34620038 |
| 100 | STK3 | 0.34537933 |
| 101 | MAP2K7 | 0.34036883 |
| 102 | AKT2 | 0.33285389 |
| 103 | CDK11A | 0.32611109 |
| 104 | MAP4K2 | 0.32257407 |
| 105 | PNCK | 0.31043456 |
| 106 | CDK15 | 0.29285509 |
| 107 | CDK18 | 0.28850021 |
| 108 | MAPKAPK5 | 0.27848020 |
| 109 | LATS1 | 0.27716875 |
| 110 | PRKDC | 0.27618149 |
| 111 | INSRR | 0.27458216 |
| 112 | MAPK11 | 0.27312418 |
| 113 | FGFR1 | 0.27214803 |
| 114 | GRK1 | 0.26821460 |
| 115 | CSNK1G3 | 0.26027188 |
| 116 | GRK6 | 0.25827795 |
| 117 | MARK3 | 0.25461945 |
| 118 | CDK14 | 0.24702621 |
| 119 | CSNK1D | 0.23089661 |
| 120 | MAP2K6 | 0.22713183 |
| 121 | PRKCG | 0.22388977 |
| 122 | NLK | 0.22301474 |
| 123 | STK24 | 0.22000209 |
| 124 | ILK | 0.20870326 |
| 125 | BTK | 0.20804457 |
| 126 | DAPK1 | 0.20188483 |
| 127 | MTOR | 0.20025414 |
| 128 | ERBB4 | 0.19949194 |
| 129 | CDK9 | 0.19359954 |
| 130 | LIMK1 | 0.19298859 |
| 131 | AKT1 | 0.19139422 |
| 132 | EPHB2 | 0.18982411 |
| 133 | PRKACB | 0.17752372 |
| 134 | CSNK1G2 | 0.17546490 |
| 135 | BCR | 0.17236720 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.83183310 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.36254645 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 4.24062980 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.41811133 |
| 5 | Spliceosome_Homo sapiens_hsa03040 | 3.12180418 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 3.10283032 |
| 7 | Homologous recombination_Homo sapiens_hsa03440 | 3.01296950 |
| 8 | Proteasome_Homo sapiens_hsa03050 | 2.96101785 |
| 9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.93733332 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.87264577 |
| 11 | RNA transport_Homo sapiens_hsa03013 | 2.86796114 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.69622050 |
| 13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.50228680 |
| 14 | Cell cycle_Homo sapiens_hsa04110 | 2.44705065 |
| 15 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.36211255 |
| 16 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.20233342 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.17117452 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.84884100 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.70275472 |
| 20 | Alzheimers disease_Homo sapiens_hsa05010 | 1.64056703 |
| 21 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.44566896 |
| 22 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.33064883 |
| 23 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.32217804 |
| 24 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.25541126 |
| 25 | Purine metabolism_Homo sapiens_hsa00230 | 1.23079653 |
| 26 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.19318838 |
| 27 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.17293673 |
| 28 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.16776450 |
| 29 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.16760105 |
| 30 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.10702522 |
| 31 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.09566507 |
| 32 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.07817469 |
| 33 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.02185567 |
| 34 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.01589924 |
| 35 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.01032689 |
| 36 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.93824986 |
| 37 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.91786330 |
| 38 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.89530892 |
| 39 | Sulfur relay system_Homo sapiens_hsa04122 | 0.84348618 |
| 40 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.84074160 |
| 41 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.83169632 |
| 42 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.81957918 |
| 43 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.81559240 |
| 44 | Carbon metabolism_Homo sapiens_hsa01200 | 0.81067471 |
| 45 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.79444729 |
| 46 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.78882420 |
| 47 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.78151252 |
| 48 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.76213175 |
| 49 | Huntingtons disease_Homo sapiens_hsa05016 | 0.76164100 |
| 50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.74833374 |
| 51 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.74462348 |
| 52 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.70209242 |
| 53 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.69459736 |
| 54 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.68266224 |
| 55 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.66547409 |
| 56 | Parkinsons disease_Homo sapiens_hsa05012 | 0.65899694 |
| 57 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.64734037 |
| 58 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.60465901 |
| 59 | Protein export_Homo sapiens_hsa03060 | 0.60415053 |
| 60 | Thyroid cancer_Homo sapiens_hsa05216 | 0.59784015 |
| 61 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.59290113 |
| 62 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.58859495 |
| 63 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.57872257 |
| 64 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.54013380 |
| 65 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.48095617 |
| 66 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.47830195 |
| 67 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.46897883 |
| 68 | HTLV-I infection_Homo sapiens_hsa05166 | 0.46135639 |
| 69 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.45591686 |
| 70 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.43966861 |
| 71 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.41941041 |
| 72 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.41617121 |
| 73 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.41289830 |
| 74 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.40746026 |
| 75 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.40231452 |
| 76 | Metabolic pathways_Homo sapiens_hsa01100 | 0.38484736 |
| 77 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.37053708 |
| 78 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.36942224 |
| 79 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.34455723 |
| 80 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.31836263 |
| 81 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.31780488 |
| 82 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.31339876 |
| 83 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.31220466 |
| 84 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.29295465 |
| 85 | Galactose metabolism_Homo sapiens_hsa00052 | 0.29163363 |
| 86 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.29162029 |
| 87 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.29000863 |
| 88 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.28887267 |
| 89 | Phototransduction_Homo sapiens_hsa04744 | 0.27527748 |
| 90 | Peroxisome_Homo sapiens_hsa04146 | 0.27304013 |
| 91 | Bladder cancer_Homo sapiens_hsa05219 | 0.26886839 |
| 92 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.26845723 |
| 93 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.26290862 |
| 94 | Retinol metabolism_Homo sapiens_hsa00830 | 0.26145968 |
| 95 | Alcoholism_Homo sapiens_hsa05034 | 0.24927239 |
| 96 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.24537966 |
| 97 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.23105408 |
| 98 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.22754645 |
| 99 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.22628540 |
| 100 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.21591540 |
| 101 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.20876630 |
| 102 | Legionellosis_Homo sapiens_hsa05134 | 0.20328373 |
| 103 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.18751774 |
| 104 | Lysine degradation_Homo sapiens_hsa00310 | 0.18267825 |
| 105 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.17466659 |
| 106 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.17014539 |
| 107 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.16091118 |
| 108 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.15915009 |
| 109 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.15469140 |
| 110 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.14656917 |
| 111 | Olfactory transduction_Homo sapiens_hsa04740 | 0.14177433 |
| 112 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.13874905 |
| 113 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.13107586 |
| 114 | Apoptosis_Homo sapiens_hsa04210 | 0.11894374 |
| 115 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.11876207 |
| 116 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.11083961 |
| 117 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.10925785 |
| 118 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.10482723 |
| 119 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.10055297 |
| 120 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.06697038 |
| 121 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.05082511 |
| 122 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.03987447 |

