MNDA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.34260334
2negative regulation of cell killing (GO:0031342)6.34260334
3positive regulation of gamma-delta T cell activation (GO:0046645)5.97706482
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.83701741
5detection of molecule of bacterial origin (GO:0032490)5.83250172
6positive regulation of interferon-alpha production (GO:0032727)5.70792675
7cellular response to type I interferon (GO:0071357)5.59443794
8type I interferon signaling pathway (GO:0060337)5.59443794
9response to type I interferon (GO:0034340)5.56814961
10positive regulation by symbiont of host defense response (GO:0052509)5.54646593
11modulation by symbiont of host defense response (GO:0052031)5.54646593
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.54646593
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.54646593
14positive regulation by organism of defense response of other organism involved in symbiotic interact5.54646593
15modulation by symbiont of host immune response (GO:0052553)5.54646593
16detection of other organism (GO:0098543)5.39634151
17regulation of interferon-alpha production (GO:0032647)5.38495395
18cellular response to interferon-alpha (GO:0035457)5.22709510
19regulation of B cell receptor signaling pathway (GO:0050855)5.18745902
20neutrophil activation involved in immune response (GO:0002283)5.15743961
21detection of external biotic stimulus (GO:0098581)5.15093003
22response to interferon-alpha (GO:0035455)5.00561651
23detection of bacterium (GO:0016045)4.88733218
24cellular extravasation (GO:0045123)4.71265243
25negative regulation of viral genome replication (GO:0045071)4.69666872
26response to peptidoglycan (GO:0032494)4.66319148
27immunoglobulin mediated immune response (GO:0016064)4.63180772
28cellular response to exogenous dsRNA (GO:0071360)4.55147662
29detection of biotic stimulus (GO:0009595)4.49619530
30natural killer cell mediated immunity (GO:0002228)4.44377957
31natural killer cell mediated cytotoxicity (GO:0042267)4.44377957
32negative regulation of interleukin-12 production (GO:0032695)4.42904043
33leukocyte migration involved in inflammatory response (GO:0002523)4.39242691
34negative regulation of lymphocyte mediated immunity (GO:0002707)4.36416127
35leukocyte aggregation (GO:0070486)4.35272178
36lipopolysaccharide-mediated signaling pathway (GO:0031663)4.32034002
37neutrophil mediated immunity (GO:0002446)4.29255119
38regulation of gamma-delta T cell activation (GO:0046643)4.27509625
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.26390750
40positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.25399280
41positive regulation of type 2 immune response (GO:0002830)4.21558545
42regulation of T-helper 1 cell differentiation (GO:0045625)4.20290193
43macrophage activation involved in immune response (GO:0002281)4.18896211
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.16143832
45response to host immune response (GO:0052572)4.16143832
46positive regulation of natural killer cell differentiation (GO:0032825)4.14025398
47positive regulation of cAMP-mediated signaling (GO:0043950)4.13988600
48response to interleukin-15 (GO:0070672)4.13834004
49hydrogen peroxide biosynthetic process (GO:0050665)4.12606857
50cellular response to interferon-beta (GO:0035458)4.06509275
51regulation of interferon-beta biosynthetic process (GO:0045357)4.04119695
52antigen processing and presentation of endogenous antigen (GO:0019883)4.02770241
53respiratory burst (GO:0045730)4.02490015
54positive regulation of interferon-beta production (GO:0032728)4.02216468
55positive regulation of chemokine biosynthetic process (GO:0045080)4.01648097
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.99746556
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.99746556
58T-helper 1 type immune response (GO:0042088)3.98372107
59interferon-gamma-mediated signaling pathway (GO:0060333)3.94945024
60granulocyte activation (GO:0036230)3.94204410
61regulation of RIG-I signaling pathway (GO:0039535)3.91935427
62cellular response to virus (GO:0098586)3.87518140
63positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.84269574
64regulation of gamma-delta T cell differentiation (GO:0045586)3.84252924
65cellular response to interleukin-15 (GO:0071350)3.82676003
66antigen processing and presentation via MHC class Ib (GO:0002475)3.82330604
67negative regulation of leukocyte mediated immunity (GO:0002704)3.75856784
68neutrophil activation (GO:0042119)3.75549545
69negative regulation of T cell mediated immunity (GO:0002710)3.73486968
70response to interferon-beta (GO:0035456)3.70608917
71myeloid leukocyte mediated immunity (GO:0002444)3.70540165
72regulation of mononuclear cell migration (GO:0071675)3.67229935
73regulation of mast cell degranulation (GO:0043304)3.67199134
74positive regulation of mast cell activation (GO:0033005)3.66508576
75lymphocyte chemotaxis (GO:0048247)3.66229440
76response to host (GO:0075136)3.66179098
77response to host defenses (GO:0052200)3.66179098
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.66179098
79regulation of dendritic cell antigen processing and presentation (GO:0002604)3.65481397
80reactive oxygen species biosynthetic process (GO:1903409)3.64524976
81defense response to protozoan (GO:0042832)3.60472089
82positive regulation of antigen processing and presentation (GO:0002579)3.60300251
83regulation of activation of Janus kinase activity (GO:0010533)3.58413769
84superoxide anion generation (GO:0042554)3.57887868
85negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.57583081
86eosinophil chemotaxis (GO:0048245)3.56157036
87negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.54563052
88regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.52668731
89positive regulation of interleukin-12 production (GO:0032735)3.51972384
90positive regulation of heat generation (GO:0031652)3.51892821
91T cell migration (GO:0072678)3.50780985
92positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.50361339
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.50346042
94positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.49681106
95microglial cell activation (GO:0001774)3.49046001
96positive regulation of toll-like receptor signaling pathway (GO:0034123)3.47638288
97B cell mediated immunity (GO:0019724)3.46776686
98positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.44101635
99regulation of myeloid leukocyte mediated immunity (GO:0002886)3.43417884
100regulation of chemokine biosynthetic process (GO:0045073)3.42699844
101regulation of fever generation (GO:0031620)3.40467059
102regulation of mast cell activation involved in immune response (GO:0033006)3.39854822
103positive regulation of T cell cytokine production (GO:0002726)3.36357337
104regulation of mast cell activation (GO:0033003)3.32348775
105regulation of interferon-gamma biosynthetic process (GO:0045072)3.32335315
106positive regulation of interleukin-17 production (GO:0032740)3.31149058
107defense response to virus (GO:0051607)3.30894752
108cellular response to interferon-gamma (GO:0071346)3.30578891
109positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.30472026
110monocyte chemotaxis (GO:0002548)3.29280715
111myeloid cell activation involved in immune response (GO:0002275)3.27681990
112positive regulation of monocyte chemotaxis (GO:0090026)3.27355183
113regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.26388676
114regulation of type I interferon-mediated signaling pathway (GO:0060338)3.25011870
115regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.24944059
116regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.24692713
117dendritic cell migration (GO:0036336)3.21389778
118regulation of antigen processing and presentation (GO:0002577)3.20938812
119regulation of leukocyte degranulation (GO:0043300)3.20896200
120leukocyte mediated cytotoxicity (GO:0001909)3.19935840
121positive regulation of mast cell degranulation (GO:0043306)3.19832074
122regulation of B cell differentiation (GO:0045577)3.19318887
123leukocyte degranulation (GO:0043299)3.18621881
124* B cell receptor signaling pathway (GO:0050853)3.17472991
125myeloid dendritic cell differentiation (GO:0043011)3.16792061
126eosinophil migration (GO:0072677)3.16656098
127regulation of tolerance induction (GO:0002643)3.16608167
128negative regulation of myeloid cell apoptotic process (GO:0033033)3.15545642
129response to muramyl dipeptide (GO:0032495)3.15311726
130positive regulation of response to biotic stimulus (GO:0002833)3.09125623
131negative thymic T cell selection (GO:0045060)3.07362975
132dendritic cell chemotaxis (GO:0002407)3.07045093
133negative regulation of interleukin-17 production (GO:0032700)3.05256473
134response to protozoan (GO:0001562)3.05249812
135macrophage activation (GO:0042116)3.04087625
136negative regulation of T-helper cell differentiation (GO:0045623)3.04087457
137negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.04087457
138positive regulation of cellular amide metabolic process (GO:0034250)3.02993446
139myeloid leukocyte activation (GO:0002274)3.02705246
140response to interferon-gamma (GO:0034341)3.02700680
141regulation of T-helper 2 cell differentiation (GO:0045628)3.02416470
142negative T cell selection (GO:0043383)3.02127531
143negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.00960316
144negative regulation of type 2 immune response (GO:0002829)3.00819978
145regulation of interleukin-17 production (GO:0032660)3.00373224
146positive regulation of B cell differentiation (GO:0045579)3.00351696
147regulation of T cell tolerance induction (GO:0002664)3.00187252
148production of molecular mediator involved in inflammatory response (GO:0002532)2.96450873
149positive regulation of lymphocyte migration (GO:2000403)2.96152583
150cellular response to zinc ion (GO:0071294)2.95711651
151positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.95539917
152positive regulation of T-helper cell differentiation (GO:0045624)2.95426318
153positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.94689268
154positive thymic T cell selection (GO:0045059)2.93662877
155regulation of T cell mediated cytotoxicity (GO:0001914)2.92758643
156regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.92650161
157negative regulation of B cell mediated immunity (GO:0002713)2.91017309
158negative regulation of immunoglobulin mediated immune response (GO:0002890)2.91017309
159positive regulation of mast cell activation involved in immune response (GO:0033008)2.89330246

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.61358466
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.62383394
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.49958732
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.38280122
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.16917375
6IRF8_27001747_Chip-Seq_BMDM_Mouse4.47472047
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.93854362
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.80078687
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.61455338
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.31994468
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.28521931
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.92209246
13* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.79767849
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.62763152
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.61985423
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.60133845
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.47252343
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46126185
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.23798292
20GATA1_22025678_ChIP-Seq_K562_Human2.14909038
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00122847
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98341158
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88923103
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.70356810
25PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69427746
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66683807
27TCF7_22412390_ChIP-Seq_EML_Mouse1.66196302
28* SPI1_23547873_ChIP-Seq_NB4_Human1.62388276
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61552983
30PU_27001747_Chip-Seq_BMDM_Mouse1.60854261
31MYC_22102868_ChIP-Seq_BL_Human1.56640435
32CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54979825
33GATA1_19941827_ChIP-Seq_MEL_Mouse1.53609073
34MYB_26560356_Chip-Seq_TH2_Human1.52633592
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.51717923
36CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51227547
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50136817
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49491850
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.49249118
40VDR_24787735_ChIP-Seq_THP-1_Human1.48260015
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44557692
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43673272
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39539360
44EGR1_19032775_ChIP-ChIP_M12_Human1.34487892
45KDM2B_26808549_Chip-Seq_DND41_Human1.33994897
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32830875
47MAF_26560356_Chip-Seq_TH1_Human1.30287376
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26924641
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26735799
50VDR_24763502_ChIP-Seq_THP-1_Human1.24440009
51CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24393253
52* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23443594
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23397615
54RUNX_20019798_ChIP-Seq_JUKART_Human1.20874022
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20403836
56SPI1_23127762_ChIP-Seq_K562_Human1.20302923
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19981185
58PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19497222
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19354581
60MYB_26560356_Chip-Seq_TH1_Human1.19212562
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17723543
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17406181
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16575742
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15162590
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14580092
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.14014141
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13711239
68GATA3_26560356_Chip-Seq_TH2_Human1.12318504
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04898242
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.04897430
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03672737
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01496903
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01496903
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01323622
75GATA1_19941826_ChIP-Seq_K562_Human1.00183853
76EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99830323
77* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98443154
78SOX2_20726797_ChIP-Seq_SW620_Human0.97970596
79STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95089317
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94794487
81KDM2B_26808549_Chip-Seq_JURKAT_Human0.94452735
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94346373
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94002763
84* GATA3_27048872_Chip-Seq_THYMUS_Human0.93854891
85* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93336211
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92202112
87* GATA2_19941826_ChIP-Seq_K562_Human0.89467591
88GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85615120
89GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85431544
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85379043
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84992947
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84428189
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78550687
94RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77552686
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76968543
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76807720
97CJUN_26792858_Chip-Seq_BT549_Human0.76806410
98IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76765270
99SCL_19346495_ChIP-Seq_HPC-7_Human0.74458750
100BCL6_27268052_Chip-Seq_Bcells_Human0.72862721
101NCOR1_26117541_ChIP-Seq_K562_Human0.72184067
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.71677787
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71044264
104JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70478006
105KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.67172116
106UTX_26944678_Chip-Seq_JUKART_Human0.66960265
107VDR_21846776_ChIP-Seq_THP-1_Human0.66297342
108* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66276382
109ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.64165856
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.63256973
111BCOR_27268052_Chip-Seq_Bcells_Human0.63049257
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.61210508
113HOXB4_20404135_ChIP-ChIP_EML_Mouse0.60930860
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.60915523
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.60915523
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.60872789
117MAF_26560356_Chip-Seq_TH2_Human0.60852041
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.60217145
119CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.60004484
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.60002986
121* SMRT_27268052_Chip-Seq_Bcells_Human0.58892721
122P63_26484246_Chip-Seq_KERATINOCYTES_Human0.57473397
123LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.56797863
124TP53_18474530_ChIP-ChIP_U2OS_Human0.53046051
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.52645560
126SPI1_20517297_ChIP-Seq_HL60_Human0.51938537
127SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.50364179
128* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.45969177
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.44824902

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.05573064
2MP0009785_altered_susceptibility_to4.31517281
3MP0002148_abnormal_hypersensitivity_rea3.92650603
4MP0003436_decreased_susceptibility_to3.87394247
5MP0006082_CNS_inflammation3.61396606
6MP0003724_increased_susceptibility_to3.57735744
7MP0003303_peritoneal_inflammation3.31310955
8MP0005000_abnormal_immune_tolerance3.30076321
9MP0005025_abnormal_response_to3.20646094
10MP0001790_abnormal_immune_system3.11548312
11MP0005387_immune_system_phenotype3.11548312
12MP0002419_abnormal_innate_immunity3.06465595
13MP0000685_abnormal_immune_system2.98010393
14MP0004510_myositis2.96691047
15MP0005671_abnormal_response_to2.86046132
16MP0002452_abnormal_antigen_presenting2.65338230
17MP0002723_abnormal_immune_serum2.57182772
18MP0001800_abnormal_humoral_immune2.54646017
19MP0005058_abnormal_lysosome_morphology2.52504438
20MP0001533_abnormal_skeleton_physiology2.32419432
21MP0001819_abnormal_immune_cell2.19907829
22MP0009764_decreased_sensitivity_to2.17108986
23MP0002420_abnormal_adaptive_immunity2.13402684
24MP0002132_abnormal_respiratory_system2.00707028
25MP0003448_altered_tumor_morphology1.96176132
26MP0004947_skin_inflammation1.93767379
27MP0001845_abnormal_inflammatory_respons1.90338218
28MP0002006_tumorigenesis1.78513461
29MP0004883_abnormal_blood_vessel1.77411995
30MP0008469_abnormal_protein_level1.76001596
31MP0001853_heart_inflammation1.75224863
32MP0003172_abnormal_lysosome_physiology1.74263306
33MP0005464_abnormal_platelet_physiology1.73725459
34MP0004381_abnormal_hair_follicle1.71878437
35MP0003075_altered_response_to1.71550566
36MP0005451_abnormal_body_composition1.69738519
37MP0003866_abnormal_defecation1.61931755
38MP0000343_altered_response_to1.61895805
39MP0000465_gastrointestinal_hemorrhage1.61499059
40MP0002405_respiratory_system_inflammati1.60597563
41MP0010155_abnormal_intestine_physiology1.60428715
42MP0009278_abnormal_bone_marrow1.59666699
43MP0002396_abnormal_hematopoietic_system1.59295941
44MP0002998_abnormal_bone_remodeling1.54636099
45MP0000716_abnormal_immune_system1.51898061
46MP0005310_abnormal_salivary_gland1.51113570
47MP0008438_abnormal_cutaneous_collagen1.46270873
48MP0002277_abnormal_respiratory_mucosa1.41306830
49MP0000858_altered_metastatic_potential1.40224651
50MP0000703_abnormal_thymus_morphology1.38701853
51MP0009840_abnormal_foam_cell1.38677464
52MP0002166_altered_tumor_susceptibility1.36568222
53MP0002398_abnormal_bone_marrow1.36012018
54MP0009333_abnormal_splenocyte_physiolog1.28334542
55MP0004782_abnormal_surfactant_physiolog1.27585443
56MP0005397_hematopoietic_system_phenotyp1.27272999
57MP0001545_abnormal_hematopoietic_system1.27272999
58MP0005164_abnormal_response_to1.25452285
59MP0003191_abnormal_cellular_cholesterol1.23940600
60MP0005166_decreased_susceptibility_to1.18380075
61MP0005390_skeleton_phenotype1.17556701
62MP0002429_abnormal_blood_cell1.16955327
63MP0000604_amyloidosis1.16371511
64MP0003186_abnormal_redox_activity1.15304705
65MP0002254_reproductive_system_inflammat1.09378237
66MP0009763_increased_sensitivity_to1.08540461
67MP0010307_abnormal_tumor_latency1.08024605
68MP0005075_abnormal_melanosome_morpholog1.02383930
69MP0005076_abnormal_cell_differentiation1.02294777
70MP0000689_abnormal_spleen_morphology1.01231941
71MP0000015_abnormal_ear_pigmentation0.99273837
72MP0003300_gastrointestinal_ulcer0.99194763
73MP0003690_abnormal_glial_cell0.97768944
74MP0003045_fibrosis0.97304011
75MP0005167_abnormal_blood-brain_barrier0.96967660
76MP0002722_abnormal_immune_system0.96000288
77MP0003195_calcinosis0.94733971
78MP0000569_abnormal_digit_pigmentation0.94370023
79MP0003453_abnormal_keratinocyte_physiol0.93899365
80MP0003656_abnormal_erythrocyte_physiolo0.92978948
81MP0002138_abnormal_hepatobiliary_system0.91711311
82MP0003221_abnormal_cardiomyocyte_apopto0.90886176
83MP0003091_abnormal_cell_migration0.89454686
84MP0003787_abnormal_imprinting0.84772112
85MP0004858_abnormal_nervous_system0.84183942
86MP0003566_abnormal_cell_adhesion0.80345510
87MP0001851_eye_inflammation0.77678813
88MP0002933_joint_inflammation0.76180392
89MP0001663_abnormal_digestive_system0.75330826
90MP0004130_abnormal_muscle_cell0.75007683
91MP0010352_gastrointestinal_tract_polyps0.74688792
92MP0000249_abnormal_blood_vessel0.74661812
93MP0008004_abnormal_stomach_pH0.72638492
94MP0003763_abnormal_thymus_physiology0.69880306
95MP0001958_emphysema0.69321751
96MP0001348_abnormal_lacrimal_gland0.68219484
97MP0004484_altered_response_of0.68098645
98MP0008874_decreased_physiological_sensi0.68066176
99MP0003828_pulmonary_edema0.67460267
100MP0005174_abnormal_tail_pigmentation0.64184364
101MP0003795_abnormal_bone_structure0.63317585
102MP0001881_abnormal_mammary_gland0.62294711
103MP0002136_abnormal_kidney_physiology0.62259440
104MP0005023_abnormal_wound_healing0.61487570
105MP0003806_abnormal_nucleotide_metabolis0.61399742
106MP0002332_abnormal_exercise_endurance0.60734135
107MP0003183_abnormal_peptide_metabolism0.59631482
108MP0010386_abnormal_urinary_bladder0.59576607
109MP0002133_abnormal_respiratory_system0.59253532
110MP0005388_respiratory_system_phenotype0.59253532
111MP0005257_abnormal_intraocular_pressure0.58559882
112MP0003252_abnormal_bile_duct0.58094487
113MP0005376_homeostasis/metabolism_phenot0.57367901
114MP0001986_abnormal_taste_sensitivity0.57151497
115MP0005275_abnormal_skin_tensile0.56533468
116MP0002928_abnormal_bile_duct0.56370730
117MP0002090_abnormal_vision0.55964424
118MP0003705_abnormal_hypodermis_morpholog0.55916464
119MP0008260_abnormal_autophagy0.55729825
120MP0000767_abnormal_smooth_muscle0.55482494
121MP0004808_abnormal_hematopoietic_stem0.51870054
122MP0005319_abnormal_enzyme/_coenzyme0.50567179
123MP0000490_abnormal_crypts_of0.50351880
124MP0003329_amyloid_beta_deposits0.49132364
125MP0005165_increased_susceptibility_to0.48464563
126MP0002295_abnormal_pulmonary_circulatio0.48377217
127MP0009765_abnormal_xenobiotic_induced0.47811749
128MP0000627_abnormal_mammary_gland0.47024793
129MP0005083_abnormal_biliary_tract0.46385872

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.64251718
2Recurrent abscess formation (HP:0002722)6.84688624
3Recurrent bacterial skin infections (HP:0005406)6.64694383
4Recurrent gram-negative bacterial infections (HP:0005420)6.02729793
5Abnormality of macrophages (HP:0004311)5.31115818
6Autoimmune thrombocytopenia (HP:0001973)5.30966077
7Mediastinal lymphadenopathy (HP:0100721)4.90083387
8Elevated erythrocyte sedimentation rate (HP:0003565)4.77828941
9Increased IgM level (HP:0003496)4.66989577
10Systemic lupus erythematosus (HP:0002725)4.32977375
11Basal ganglia calcification (HP:0002135)4.30722857
12Keratoconjunctivitis sicca (HP:0001097)4.30280539
13Recurrent skin infections (HP:0001581)4.24267694
14Gingivitis (HP:0000230)4.18752608
15Keratoconjunctivitis (HP:0001096)3.97594215
16Recurrent fungal infections (HP:0002841)3.94346610
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.91090086
18Hypochromic microcytic anemia (HP:0004840)3.88360091
19Encephalitis (HP:0002383)3.87960214
20Stomatitis (HP:0010280)3.86545865
21Vasculitis (HP:0002633)3.83873249
22T lymphocytopenia (HP:0005403)3.63227913
23Vacuolated lymphocytes (HP:0001922)3.62690943
24Recurrent viral infections (HP:0004429)3.60031921
25Interstitial pulmonary disease (HP:0006530)3.59812066
26Increased cerebral lipofuscin (HP:0011813)3.58072320
27Obstructive lung disease (HP:0006536)3.57816620
28Chronic obstructive pulmonary disease (HP:0006510)3.57816620
29Tetraparesis (HP:0002273)3.55372237
30Myositis (HP:0100614)3.52204740
31Prostate neoplasm (HP:0100787)3.51643295
32Hypergammaglobulinemia (HP:0010702)3.51011715
33Orchitis (HP:0100796)3.47798366
34Chronic otitis media (HP:0000389)3.47367111
35Increased neuronal autofluorescent lipopigment (HP:0002074)3.44944086
36Chest pain (HP:0100749)3.43946822
37Axonal loss (HP:0003447)3.39350099
38Thick nail (HP:0001805)3.35620468
39Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.25587747
40Hypochromic anemia (HP:0001931)3.23237568
41Cellulitis (HP:0100658)3.19792258
42Optic neuritis (HP:0100653)3.16511061
43Retrobulbar optic neuritis (HP:0100654)3.16511061
44Chronic mucocutaneous candidiasis (HP:0002728)3.15746564
45Recurrent cutaneous fungal infections (HP:0011370)3.15746564
46Periodontitis (HP:0000704)3.14509543
47Prolonged bleeding time (HP:0003010)3.08343076
48Porencephaly (HP:0002132)3.05651319
49Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.01828845
50Episodic fever (HP:0001954)3.01118222
51Recurrent pneumonia (HP:0006532)2.96400995
52Urticaria (HP:0001025)2.93887243
53Pustule (HP:0200039)2.92831817
54Pulmonary embolism (HP:0002204)2.91833955
55Gastrointestinal infarctions (HP:0005244)2.87979593
56Amyloidosis (HP:0011034)2.86723360
57Abnormality of T cells (HP:0002843)2.81166956
58Disinhibition (HP:0000734)2.79538958
59Epistaxis (HP:0000421)2.78159784
60Recurrent lower respiratory tract infections (HP:0002783)2.77616494
61Premature loss of primary teeth (HP:0006323)2.71919716
62Pulmonary infiltrates (HP:0002113)2.67515847
63Osteolytic defects of the phalanges of the hand (HP:0009771)2.66519475
64Osteolytic defects of the hand bones (HP:0009699)2.66519475
65Vertebral compression fractures (HP:0002953)2.64973388
66Osteomyelitis (HP:0002754)2.64729854
67Poor head control (HP:0002421)2.64428045
68Gangrene (HP:0100758)2.62749416
69Abnormality of liposaccharide metabolism (HP:0010968)2.60962858
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.60962858
71Abnormality of glycolipid metabolism (HP:0010969)2.60962858
72Nasal polyposis (HP:0100582)2.59238320
73Abnormality of the peritoneum (HP:0002585)2.58956926
74Autoimmune hemolytic anemia (HP:0001890)2.55554293
75Inflammation of the large intestine (HP:0002037)2.53830902
76Abnormality of the pleura (HP:0002103)2.48652127
77Microcytic anemia (HP:0001935)2.48340279
78Granulocytopenia (HP:0001913)2.46594638
79Glomerulonephritis (HP:0000099)2.41824298
80Myocardial infarction (HP:0001658)2.41551791
81Gastrointestinal inflammation (HP:0004386)2.41365243
82Gingival bleeding (HP:0000225)2.41033964
83Sepsis (HP:0100806)2.39197613
84Hemoptysis (HP:0002105)2.37981776
85Meningitis (HP:0001287)2.37470587
86Abnormality of the nasal mucosa (HP:0000433)2.35627098
87Leukocytosis (HP:0001974)2.33604491
88Abnormality of the endocardium (HP:0004306)2.31528631
89Increased IgE level (HP:0003212)2.28386989
90Loss of speech (HP:0002371)2.28203548
91Acute hepatic failure (HP:0006554)2.27823981
92Bone pain (HP:0002653)2.25374784
93Prolonged neonatal jaundice (HP:0006579)2.24951763
94Progressive visual loss (HP:0000529)2.24053297
95Hepatosplenomegaly (HP:0001433)2.23788525
96Glomerulopathy (HP:0100820)2.23529433
97Subacute progressive viral hepatitis (HP:0006572)2.23341616
98Recurrent bronchitis (HP:0002837)2.20245517
99Panhypogammaglobulinemia (HP:0003139)2.19559470
100Nephritis (HP:0000123)2.19328414
101Peritonitis (HP:0002586)2.19220328
102Purpura (HP:0000979)2.18918680
103Petechiae (HP:0000967)2.18128815
104Keratitis (HP:0000491)2.16864844
105Vertigo (HP:0002321)2.14425675
106Eosinophilia (HP:0001880)2.13685029
107Hematochezia (HP:0002573)2.12136062
108Dysostosis multiplex (HP:0000943)2.11234916
109Abnormality of the pericardium (HP:0001697)2.11015432
110Viral hepatitis (HP:0006562)2.10841168
111Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10795217
112Pathologic fracture (HP:0002756)2.10108817
113Arterial thrombosis (HP:0004420)2.08569267
114Skin ulcer (HP:0200042)2.07053431
115Cleft eyelid (HP:0000625)2.06733737
116Slow saccadic eye movements (HP:0000514)2.05295989
117Chronic sinusitis (HP:0011109)2.05199533
118Lymphopenia (HP:0001888)2.04653853
119Anorexia (HP:0002039)2.02815807
120Polycythemia (HP:0001901)2.01228699
121Acne (HP:0001061)1.99003953
122Thrombophlebitis (HP:0004418)1.98914714
123Emphysema (HP:0002097)1.98700415
124Abnormality of cells of the lymphoid lineage (HP:0012140)1.97263740
125Abnormal platelet volume (HP:0011876)1.95131961
126Esophageal neoplasm (HP:0100751)1.94173806
127Neoplasm of head and neck (HP:0012288)1.94173806
128Abnormality of T cell number (HP:0011839)1.93078423
129Mucopolysacchariduria (HP:0008155)1.93029537
130Urinary glycosaminoglycan excretion (HP:0003541)1.93029537
131Arthralgia (HP:0002829)1.92645484
132Abnormality of T cell physiology (HP:0011840)1.92030777
133Colitis (HP:0002583)1.91064494
134Abnormality of the prostate (HP:0008775)1.90683924
135Joint swelling (HP:0001386)1.89278323
136Abnormality of the basal ganglia (HP:0002134)1.87982522
137Spontaneous hematomas (HP:0007420)1.87943495
138Polyneuropathy (HP:0001271)1.87499014
139Skin rash (HP:0000988)1.87220061
140Abnormality of eosinophils (HP:0001879)1.85376152
141Cheilitis (HP:0100825)1.85298488
142Agnosia (HP:0010524)1.84421334
143Amaurosis fugax (HP:0100576)1.82243465
144IgM deficiency (HP:0002850)1.81549545
145Toxemia of pregnancy (HP:0100603)1.79060112
146Difficulty running (HP:0009046)1.74599721
147Abnormality of the heme biosynthetic pathway (HP:0010472)1.73202718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.37721912
2MAP3K144.81908447
3TYK23.90342606
4TBK13.76583532
5RIPK43.39436862
6IKBKE3.31009049
7MAP2K33.15476700
8BLK3.01956067
9IRAK42.96778820
10JAK32.88205267
11PIM22.69505955
12JAK12.67352297
13GRK62.33435073
14ERN12.28482694
15MAP3K132.28461484
16IKBKB2.22743834
17FGFR42.17562306
18IRAK32.14773379
19KIT2.06298122
20TNK21.97637400
21EPHA31.96595954
22EPHB11.78737945
23TXK1.71288159
24PRPF4B1.65499008
25TAOK31.57843860
26TAOK11.55144645
27CSK1.49500800
28MAP4K11.47761759
29CHUK1.45076321
30ARAF1.41389772
31MST41.41286937
32BMPR21.37255252
33FGFR31.36590294
34IRAK11.33104187
35MAP3K21.32599052
36MAP3K61.27621982
37EIF2AK21.27612659
38ABL21.23510366
39NEK91.23402621
40SYK1.20276504
41HCK1.15102117
42ITK1.13246463
43BMX1.12278826
44MAP3K51.11601649
45ZAP701.10243294
46CDK191.09004887
47MATK1.06793157
48JAK21.06301878
49NME21.01527152
50RPS6KA40.98591566
51STK40.97501497
52LYN0.97230988
53LCK0.96406899
54MARK20.92353159
55FGR0.91594478
56PIM10.89121710
57RIPK10.88787797
58MAP2K40.87370869
59PDK10.84778233
60PTK60.83817971
61PTK2B0.82923948
62MST1R0.80698698
63ERBB30.77591419
64CSF1R0.73493650
65PDPK10.70848513
66TRPM70.69981112
67KSR10.68999237
68IRAK20.67137356
69STK110.65408434
70EGFR0.64151589
71ABL10.62158013
72BTK0.62115529
73PRKD20.61036966
74PRKCD0.60477897
75NLK0.58791289
76SGK30.58398673
77FES0.57563452
78MAP2K60.56387186
79WNK10.55572089
80TAOK20.55551758
81MOS0.54567453
82RET0.54015888
83SIK20.53176558
84MAP3K70.52989714
85YES10.52929106
86DYRK30.52720161
87DAPK30.52244654
88TEC0.49393226
89MARK30.47991847
90SGK20.47982918
91CAMKK20.47522335
92MAPK120.46999434
93TRIB30.46660441
94STK380.46053076
95TESK20.45590793
96PRKCQ0.45576071
97MAP3K10.42758769
98HIPK20.40342864
99GRK70.39641866
100TGFBR20.38789030
101DAPK20.37967180
102STK100.37527251
103RPS6KA50.37178986
104MAPK70.37127809
105MAP3K100.36982504
106STK30.36042453
107DYRK1B0.35424732
108CAMKK10.34984826
109CLK10.33987552
110RPS6KL10.33455017
111RPS6KC10.33455017
112TESK10.32790990
113CDC42BPA0.31764437
114PRKCZ0.31349052
115SMG10.31060050
116SIK30.31037856
117ADRBK20.30856758
118PLK20.30818559
119ALK0.27591340
120PRKD10.26070376
121TTN0.25200965
122KSR20.23216092
123FYN0.23062478
124CDK60.22583055
125PKN10.22348657
126CAMK1D0.21097026
127BMPR1B0.20451879
128ERBB40.20368052
129INSR0.19833248
130MAPKAPK20.19676649
131DDR20.19133904
132IGF1R0.17974806
133LRRK20.17281062
134NUAK10.17166727
135MAP3K30.16258732
136RAF10.15781501
137MAP3K90.15212321
138SRC0.14287934
139RPS6KA10.12990409
140MAP3K110.12573744
141RPS6KA60.12132262
142PIK3CG0.11454835

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.51129601
2Toll-like receptor signaling pathway_Homo sapiens_hsa046203.34525873
3Allograft rejection_Homo sapiens_hsa053303.17849400
4Leishmaniasis_Homo sapiens_hsa051403.17299699
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.08001927
6Staphylococcus aureus infection_Homo sapiens_hsa051502.82965068
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.74770117
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.61634427
9Legionellosis_Homo sapiens_hsa051342.42446681
10Measles_Homo sapiens_hsa051622.39775508
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.38778170
12Pertussis_Homo sapiens_hsa051332.32259648
13Malaria_Homo sapiens_hsa051442.29116635
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.27966435
15Influenza A_Homo sapiens_hsa051642.22986435
16Osteoclast differentiation_Homo sapiens_hsa043802.21760111
17Rheumatoid arthritis_Homo sapiens_hsa053232.21550572
18Type I diabetes mellitus_Homo sapiens_hsa049402.18897258
19Asthma_Homo sapiens_hsa053102.13948192
20TNF signaling pathway_Homo sapiens_hsa046682.06558917
21Tuberculosis_Homo sapiens_hsa051522.00318112
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92710979
23Herpes simplex infection_Homo sapiens_hsa051681.91059254
24African trypanosomiasis_Homo sapiens_hsa051431.89672749
25Salmonella infection_Homo sapiens_hsa051321.68314870
26Toxoplasmosis_Homo sapiens_hsa051451.65088658
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.57193592
28Phagosome_Homo sapiens_hsa041451.57136643
29Antigen processing and presentation_Homo sapiens_hsa046121.56728374
30Autoimmune thyroid disease_Homo sapiens_hsa053201.55460253
31Lysosome_Homo sapiens_hsa041421.53519391
32Chemokine signaling pathway_Homo sapiens_hsa040621.48206803
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47432593
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.35596655
35Hepatitis C_Homo sapiens_hsa051601.34289998
36Non-small cell lung cancer_Homo sapiens_hsa052231.32512191
37Apoptosis_Homo sapiens_hsa042101.31841418
38Viral myocarditis_Homo sapiens_hsa054161.24151479
39Shigellosis_Homo sapiens_hsa051311.19934525
40B cell receptor signaling pathway_Homo sapiens_hsa046621.19482728
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19083978
42Hepatitis B_Homo sapiens_hsa051611.17939751
43Hematopoietic cell lineage_Homo sapiens_hsa046401.10792096
44Primary immunodeficiency_Homo sapiens_hsa053401.07765500
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04811467
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99571413
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.96013227
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93963503
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93948018
50Amoebiasis_Homo sapiens_hsa051460.91626486
51Renal cell carcinoma_Homo sapiens_hsa052110.90116114
52Prion diseases_Homo sapiens_hsa050200.89305379
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83625988
54Other glycan degradation_Homo sapiens_hsa005110.77751397
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73932599
56Prolactin signaling pathway_Homo sapiens_hsa049170.69959321
57Endometrial cancer_Homo sapiens_hsa052130.68137009
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66313823
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.64802072
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64096894
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.64044961
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62604816
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61854279
64Acute myeloid leukemia_Homo sapiens_hsa052210.60729246
65T cell receptor signaling pathway_Homo sapiens_hsa046600.59710789
66GnRH signaling pathway_Homo sapiens_hsa049120.59574573
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57789745
68Choline metabolism in cancer_Homo sapiens_hsa052310.55943305
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55054631
70Regulation of autophagy_Homo sapiens_hsa041400.54881951
71mTOR signaling pathway_Homo sapiens_hsa041500.54216476
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52736160
73Complement and coagulation cascades_Homo sapiens_hsa046100.52700462
74Inositol phosphate metabolism_Homo sapiens_hsa005620.52614103
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.51230569
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51092352
77Collecting duct acid secretion_Homo sapiens_hsa049660.50915743
78Chronic myeloid leukemia_Homo sapiens_hsa052200.49368063
79Epstein-Barr virus infection_Homo sapiens_hsa051690.48930306
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48233957
81Proteasome_Homo sapiens_hsa030500.47541358
82Colorectal cancer_Homo sapiens_hsa052100.46690915
83Pancreatic cancer_Homo sapiens_hsa052120.46052428
84ErbB signaling pathway_Homo sapiens_hsa040120.45296247
85HIF-1 signaling pathway_Homo sapiens_hsa040660.42439788
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42318565
87Rap1 signaling pathway_Homo sapiens_hsa040150.41994513
88Platelet activation_Homo sapiens_hsa046110.40867218
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40669550
90Glioma_Homo sapiens_hsa052140.40138145
91Viral carcinogenesis_Homo sapiens_hsa052030.39830801
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39035553
93Small cell lung cancer_Homo sapiens_hsa052220.38502107
94Type II diabetes mellitus_Homo sapiens_hsa049300.38474787
95Dorso-ventral axis formation_Homo sapiens_hsa043200.37056643
96Caffeine metabolism_Homo sapiens_hsa002320.34777994
97Mineral absorption_Homo sapiens_hsa049780.32755091
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.32677132
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.30342697
100Proteoglycans in cancer_Homo sapiens_hsa052050.29655684
101Notch signaling pathway_Homo sapiens_hsa043300.26845104
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25803974
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24960797
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22211199
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21955253
106HTLV-I infection_Homo sapiens_hsa051660.19670258
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17990838
108MicroRNAs in cancer_Homo sapiens_hsa052060.15158576
109FoxO signaling pathway_Homo sapiens_hsa040680.13968518
110Insulin resistance_Homo sapiens_hsa049310.11437141
111Steroid biosynthesis_Homo sapiens_hsa001000.11258004
112VEGF signaling pathway_Homo sapiens_hsa043700.11251100
113Endocytosis_Homo sapiens_hsa041440.11089403
114p53 signaling pathway_Homo sapiens_hsa041150.10660543
115Vibrio cholerae infection_Homo sapiens_hsa051100.08648982
116Prostate cancer_Homo sapiens_hsa052150.06423242
117MAPK signaling pathway_Homo sapiens_hsa040100.05950602
118Focal adhesion_Homo sapiens_hsa045100.04499831

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