MNS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)7.45136615
2axonemal dynein complex assembly (GO:0070286)7.04895005
3cilium movement (GO:0003341)6.89432349
4epithelial cilium movement (GO:0003351)5.74966808
5left/right pattern formation (GO:0060972)5.06587641
6motile cilium assembly (GO:0044458)5.06489351
7GTP biosynthetic process (GO:0006183)4.95551517
8axoneme assembly (GO:0035082)4.93707868
9UTP biosynthetic process (GO:0006228)4.85643505
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.77955867
11DNA replication initiation (GO:0006270)4.43616363
12UTP metabolic process (GO:0046051)4.39825151
13* cilium organization (GO:0044782)4.39287960
14cilium assembly (GO:0042384)4.31578997
15DNA strand elongation involved in DNA replication (GO:0006271)4.29785540
16telomere maintenance via semi-conservative replication (GO:0032201)4.22010736
17ventricular system development (GO:0021591)4.18109061
18DNA unwinding involved in DNA replication (GO:0006268)4.14083050
19DNA strand elongation (GO:0022616)4.11620242
20chromatin remodeling at centromere (GO:0031055)4.08111710
21establishment of protein localization to mitochondrial membrane (GO:0090151)4.07467341
22CENP-A containing nucleosome assembly (GO:0034080)4.07216832
23guanosine-containing compound biosynthetic process (GO:1901070)4.05528054
24kinetochore organization (GO:0051383)3.97735959
25protein localization to chromosome, centromeric region (GO:0071459)3.97096484
26piRNA metabolic process (GO:0034587)3.94465358
27histone exchange (GO:0043486)3.93781244
28DNA replication-dependent nucleosome organization (GO:0034723)3.89486767
29DNA replication-dependent nucleosome assembly (GO:0006335)3.89486767
30DNA replication checkpoint (GO:0000076)3.87930966
31nucleoside diphosphate phosphorylation (GO:0006165)3.87804794
32DNA replication-independent nucleosome organization (GO:0034724)3.84570603
33DNA replication-independent nucleosome assembly (GO:0006336)3.84570603
34telomere maintenance via recombination (GO:0000722)3.84129524
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.83323371
36pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.82432622
37cilium morphogenesis (GO:0060271)3.79470708
38protein localization to kinetochore (GO:0034501)3.78628028
39nuclear pore complex assembly (GO:0051292)3.78072813
40pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.77020127
41CTP biosynthetic process (GO:0006241)3.76338466
42CTP metabolic process (GO:0046036)3.76338466
43pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.75285120
44mitotic recombination (GO:0006312)3.70122131
45binding of sperm to zona pellucida (GO:0007339)3.69882989
46nuclear pore organization (GO:0006999)3.65002135
47sperm-egg recognition (GO:0035036)3.58880997
48translesion synthesis (GO:0019985)3.55794746
49male meiosis (GO:0007140)3.55680591
50DNA deamination (GO:0045006)3.53386152
51mitotic sister chromatid segregation (GO:0000070)3.50899624
52microtubule polymerization or depolymerization (GO:0031109)3.50820961
53regulation of histone H3-K9 methylation (GO:0051570)3.49569527
54pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.49445323
55response to pheromone (GO:0019236)3.48015076
56mitotic sister chromatid cohesion (GO:0007064)3.47131126
57regulation of centriole replication (GO:0046599)3.45775466
58mitotic nuclear envelope disassembly (GO:0007077)3.44646837
59resolution of meiotic recombination intermediates (GO:0000712)3.44270943
60* left/right axis specification (GO:0070986)3.43956817
61fusion of sperm to egg plasma membrane (GO:0007342)3.43488489
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.41759623
63mitotic chromosome condensation (GO:0007076)3.40354672
64ATP synthesis coupled proton transport (GO:0015986)3.39580536
65energy coupled proton transport, down electrochemical gradient (GO:0015985)3.39580536
66intra-S DNA damage checkpoint (GO:0031573)3.36416598
67intraciliary transport (GO:0042073)3.35688288
68sister chromatid segregation (GO:0000819)3.34794044
69mitotic metaphase plate congression (GO:0007080)3.34567839
70spermatid development (GO:0007286)3.34082274
71sperm motility (GO:0030317)3.33834599
72attachment of spindle microtubules to kinetochore (GO:0008608)3.31815626
73kinetochore assembly (GO:0051382)3.31466696
74synaptonemal complex organization (GO:0070193)3.30677469
75synapsis (GO:0007129)3.30284558
76cellular component assembly involved in morphogenesis (GO:0010927)3.28826534
77male meiosis I (GO:0007141)3.28602629
78acrosome assembly (GO:0001675)3.28233366
79meiotic chromosome segregation (GO:0045132)3.27809836
80microtubule bundle formation (GO:0001578)3.27174593
81metaphase plate congression (GO:0051310)3.26993184
82nucleotide-excision repair, DNA gap filling (GO:0006297)3.25746517
83chromatin assembly or disassembly (GO:0006333)3.25039109
84telomere maintenance via telomere lengthening (GO:0010833)3.24332187
85viral transcription (GO:0019083)3.22212591
86regulation of centrosome cycle (GO:0046605)3.19136622
87translational termination (GO:0006415)3.18030301
88neuron fate determination (GO:0048664)3.16980458
89membrane disassembly (GO:0030397)3.16914400
90nuclear envelope disassembly (GO:0051081)3.16914400
91establishment of integrated proviral latency (GO:0075713)3.16289650
92nonmotile primary cilium assembly (GO:0035058)3.16083423
93cell-cell recognition (GO:0009988)3.16066822
94regulation of DNA endoreduplication (GO:0032875)3.15632753
95centriole replication (GO:0007099)3.14758885
96microtubule-based movement (GO:0007018)3.13243187
97meiosis I (GO:0007127)3.12291212
98ribosomal small subunit assembly (GO:0000028)3.10984282
99pore complex assembly (GO:0046931)3.09593933
100establishment of chromosome localization (GO:0051303)3.08720834
101smoothened signaling pathway (GO:0007224)3.07536019
102meiotic nuclear division (GO:0007126)3.07238975
103protein localization to cilium (GO:0061512)3.06702937
104histone H2A acetylation (GO:0043968)3.03308468
105ATP-dependent chromatin remodeling (GO:0043044)3.01728836
106synaptonemal complex assembly (GO:0007130)3.00985201
107regulation of microtubule-based movement (GO:0060632)2.99662915
108centriole assembly (GO:0098534)2.97049887
109postreplication repair (GO:0006301)2.96468601
110chromosome condensation (GO:0030261)2.95647407
111microtubule depolymerization (GO:0007019)2.95345426
112mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.91960908
113negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.89766219
114termination of RNA polymerase II transcription (GO:0006369)2.89243278
115regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.89030682
116DNA duplex unwinding (GO:0032508)2.88691286
117DNA packaging (GO:0006323)2.88353194
118* meiotic cell cycle (GO:0051321)2.87813112
119regulation of cilium movement (GO:0003352)2.87030886
120DNA geometric change (GO:0032392)2.87027086
121cotranslational protein targeting to membrane (GO:0006613)2.85487018
122replication fork processing (GO:0031297)2.83466961
123SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.82452019
124DNA conformation change (GO:0071103)2.81788679
125chromosome organization involved in meiosis (GO:0070192)2.81439307
126negative regulation of RNA splicing (GO:0033119)2.80893634
127DNA ligation (GO:0006266)2.79924696
128regulation of chromosome segregation (GO:0051983)2.79760737
129protein targeting to ER (GO:0045047)2.77228345
130cell projection assembly (GO:0030031)2.76067277
131ribosomal small subunit biogenesis (GO:0042274)2.75765610
132retinal rod cell development (GO:0046548)2.70044943
133determination of left/right symmetry (GO:0007368)2.66974180
134establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66398746
135electron transport chain (GO:0022900)2.65950960
136establishment of planar polarity (GO:0001736)2.65492303
137establishment of tissue polarity (GO:0007164)2.65492303
138neuronal stem cell maintenance (GO:0097150)2.61677479
139negative regulation of DNA-dependent DNA replication (GO:2000104)2.61516446
140respiratory electron transport chain (GO:0022904)2.59983063
141cellular protein complex disassembly (GO:0043624)2.58788346
142otic vesicle formation (GO:0030916)2.55952847
143translational elongation (GO:0006414)2.53583288
144protein localization to endoplasmic reticulum (GO:0070972)2.53176990
145determination of bilateral symmetry (GO:0009855)2.50329942
146organelle disassembly (GO:1903008)2.47966034
147aldehyde catabolic process (GO:0046185)2.47806247
148nephron epithelium morphogenesis (GO:0072088)2.47791468
149nephron tubule morphogenesis (GO:0072078)2.47791468
150protein complex biogenesis (GO:0070271)2.44615875
151reciprocal DNA recombination (GO:0035825)2.44586848
152reciprocal meiotic recombination (GO:0007131)2.44586848
153specification of symmetry (GO:0009799)2.44526465
154primary alcohol catabolic process (GO:0034310)2.42794322
155DNA double-strand break processing (GO:0000729)2.40956388
156chaperone-mediated protein transport (GO:0072321)2.40341281
157lateral ventricle development (GO:0021670)2.38344007
158mitochondrial respiratory chain complex I assembly (GO:0032981)2.34448457
159NADH dehydrogenase complex assembly (GO:0010257)2.34448457
160mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.34448457
161negative regulation of T cell differentiation in thymus (GO:0033085)2.33881601
162centrosome organization (GO:0051297)2.33586774
163organelle assembly (GO:0070925)2.32587368
164negative regulation of inclusion body assembly (GO:0090084)2.30760775
165protein K6-linked ubiquitination (GO:0085020)2.30676902
166viral life cycle (GO:0019058)2.29829327
167lateral sprouting from an epithelium (GO:0060601)2.28575027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.31882991
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.80548039
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.74453653
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.46464685
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.63759642
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.56217572
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51056693
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93074798
9VDR_22108803_ChIP-Seq_LS180_Human2.83656039
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.80581600
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.52883968
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.50423701
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47309549
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43858816
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40105927
16AR_21909140_ChIP-Seq_LNCAP_Human2.39069743
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.38578947
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38295293
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38159793
20EZH2_22144423_ChIP-Seq_EOC_Human2.36874488
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34709229
22FUS_26573619_Chip-Seq_HEK293_Human2.31611311
23VDR_23849224_ChIP-Seq_CD4+_Human2.31107215
24EWS_26573619_Chip-Seq_HEK293_Human2.28906294
25ZNF274_21170338_ChIP-Seq_K562_Hela2.26978213
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19711729
27* E2F1_21310950_ChIP-Seq_MCF-7_Human2.14963649
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14027684
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11555695
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10407819
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05738453
32XRN2_22483619_ChIP-Seq_HELA_Human2.05403350
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05163246
34FOXP3_21729870_ChIP-Seq_TREG_Human2.01910038
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98208414
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91483937
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90282155
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88187473
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.88166596
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87970235
41GABP_19822575_ChIP-Seq_HepG2_Human1.83891566
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82871066
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79624570
44TTF2_22483619_ChIP-Seq_HELA_Human1.77615339
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76677963
46DCP1A_22483619_ChIP-Seq_HELA_Human1.71521406
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71104616
48ELK1_19687146_ChIP-ChIP_HELA_Human1.70775937
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70114196
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67967982
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62645846
52CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.61813569
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61627347
54* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59975068
55CIITA_25753668_ChIP-Seq_RAJI_Human1.56419781
56* P300_19829295_ChIP-Seq_ESCs_Human1.55552839
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54640218
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52898410
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52623980
60GBX2_23144817_ChIP-Seq_PC3_Human1.52175031
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51775169
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49079003
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48257070
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46859265
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.46243450
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46066796
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45458888
68TAF15_26573619_Chip-Seq_HEK293_Human1.45162182
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44070221
70KDM5A_27292631_Chip-Seq_BREAST_Human1.42193197
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.41686200
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41372078
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40588303
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40352786
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.39901741
76* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.37774102
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35666660
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35294226
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35280157
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35280157
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.33236445
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31131610
83IRF1_19129219_ChIP-ChIP_H3396_Human1.30989961
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29211151
85AR_21572438_ChIP-Seq_LNCaP_Human1.28743435
86MYC_22102868_ChIP-Seq_BL_Human1.27803098
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26048229
88RNF2_27304074_Chip-Seq_NSC_Mouse1.25721333
89* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25425354
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25399741
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.25096958
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25059684
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24996418
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24223210
95* SRF_21415370_ChIP-Seq_HL-1_Mouse1.23331497
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21844212
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18932191
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17256164
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16148772
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15755604
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15645594
102ER_23166858_ChIP-Seq_MCF-7_Human1.15060287
103PHF8_20622853_ChIP-Seq_HELA_Human1.14518269
104SMAD4_21799915_ChIP-Seq_A2780_Human1.12341896
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11334231
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.11286889
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08721281
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08458999
109SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07985011
110ETV1_20927104_ChIP-Seq_GIST48_Human1.06926519
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05927820
112CBP_20019798_ChIP-Seq_JUKART_Human1.05394850
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05394850
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05132192
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05039758
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.05039758
117TCF4_22108803_ChIP-Seq_LS180_Human1.04729061
118AR_25329375_ChIP-Seq_VCAP_Human1.04319657
119PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02974843
120TBL1_22424771_ChIP-Seq_293T_Human1.01950317
121NFYB_21822215_ChIP-Seq_K562_Human1.01468919
122PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00863929
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00748631
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00621767
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99714349
126NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99468908
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98572220
128RBPJ_21746931_ChIP-Seq_IB4_Human0.98301469
129IGF1R_20145208_ChIP-Seq_DFB_Human0.98282262
130* STAT3_23295773_ChIP-Seq_U87_Human0.98013202
131CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97724155
132MYC_18940864_ChIP-ChIP_HL60_Human0.97611249
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97455922
134PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97226257
135JUN_21703547_ChIP-Seq_K562_Human0.97059422
136NOTCH1_21737748_ChIP-Seq_TLL_Human0.96711516
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96431590
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96080107
139CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96002236
140NFYA_21822215_ChIP-Seq_K562_Human0.95649412
141BCAT_22108803_ChIP-Seq_LS180_Human0.95252371
142RUNX2_22187159_ChIP-Seq_PCA_Human0.94980611
143TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94873230
144TCF4_23295773_ChIP-Seq_U87_Human0.94647959
145SCL_19346495_ChIP-Seq_HPC-7_Human0.94159985
146DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93770031
147CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88438007
148TP63_19390658_ChIP-ChIP_HaCaT_Human0.88373827
149* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88105883
150SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86906918
151GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85379485
152SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84664106
153SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84232649
154GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82282113
155KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81554575
156ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81317316
157TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80332448
158NANOG_21062744_ChIP-ChIP_HESCs_Human0.79734190
159TFEB_21752829_ChIP-Seq_HELA_Human0.79251402
160GATA1_26923725_Chip-Seq_HPCs_Mouse0.76713793
161CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75408537
162VDR_21846776_ChIP-Seq_THP-1_Human0.74224125
163BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74213782
164POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.74087354
165MYB_26560356_Chip-Seq_TH1_Human0.73454305
166MYB_26560356_Chip-Seq_TH2_Human0.69830205
167* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68381288
168KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.67595262
169FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.65957558
170CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.64022424
171SPI1_23547873_ChIP-Seq_NB4_Human0.62663217
172PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.61939592

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.70130426
2MP0008057_abnormal_DNA_replication4.65753961
3MP0003693_abnormal_embryo_hatching4.45042186
4MP0003111_abnormal_nucleus_morphology4.14783034
5MP0008877_abnormal_DNA_methylation3.89957385
6MP0005410_abnormal_fertilization3.74964928
7MP0003077_abnormal_cell_cycle3.67823217
8MP0004957_abnormal_blastocyst_morpholog3.54140646
9MP0008058_abnormal_DNA_repair3.45006394
10MP0009379_abnormal_foot_pigmentation3.09989405
11MP0008007_abnormal_cellular_replicative2.73640325
12MP0001929_abnormal_gametogenesis2.67964415
13MP0002653_abnormal_ependyma_morphology2.59445345
14MP0008932_abnormal_embryonic_tissue2.46555254
15MP0000566_synostosis2.42531221
16MP0003656_abnormal_erythrocyte_physiolo2.38098360
17MP0002210_abnormal_sex_determination2.37918269
18MP0003698_abnormal_male_reproductive2.34420547
19MP0001984_abnormal_olfaction2.32039082
20MP0004147_increased_porphyrin_level2.30288246
21MP0006054_spinal_hemorrhage2.28304617
22MP0001545_abnormal_hematopoietic_system2.02619335
23MP0005397_hematopoietic_system_phenotyp2.02619335
24MP0001145_abnormal_male_reproductive2.01238560
25MP0008875_abnormal_xenobiotic_pharmacok1.98987961
26MP0002396_abnormal_hematopoietic_system1.90088848
27MP0000350_abnormal_cell_proliferation1.88853497
28MP0010030_abnormal_orbit_morphology1.87563711
29MP0004808_abnormal_hematopoietic_stem1.80857467
30MP0004043_abnormal_pH_regulation1.80451459
31MP0003136_yellow_coat_color1.79673242
32MP0001730_embryonic_growth_arrest1.79574492
33MP0005084_abnormal_gallbladder_morpholo1.78931875
34MP0000653_abnormal_sex_gland1.75875490
35MP0003786_premature_aging1.74594261
36MP0002160_abnormal_reproductive_system1.67574882
37MP0002277_abnormal_respiratory_mucosa1.65453060
38MP0001485_abnormal_pinna_reflex1.64966434
39MP0010307_abnormal_tumor_latency1.58825073
40MP0001293_anophthalmia1.54822274
41MP0005377_hearing/vestibular/ear_phenot1.54197822
42MP0003878_abnormal_ear_physiology1.54197822
43MP0002132_abnormal_respiratory_system1.48517753
44MP0003880_abnormal_central_pattern1.48065797
45MP0002249_abnormal_larynx_morphology1.46106090
46MP0000313_abnormal_cell_death1.44712610
47MP0003123_paternal_imprinting1.43632679
48MP0001188_hyperpigmentation1.39185259
49MP0002161_abnormal_fertility/fecundity1.36118896
50MP0001697_abnormal_embryo_size1.34994330
51MP0003011_delayed_dark_adaptation1.34588247
52MP0005551_abnormal_eye_electrophysiolog1.33835731
53MP0000026_abnormal_inner_ear1.32657019
54MP0003283_abnormal_digestive_organ1.32218151
55MP0003763_abnormal_thymus_physiology1.31989465
56MP0000703_abnormal_thymus_morphology1.31535899
57MP0000490_abnormal_crypts_of1.30445487
58MP0002080_prenatal_lethality1.28520322
59MP0002085_abnormal_embryonic_tissue1.24162737
60MP0002233_abnormal_nose_morphology1.21720234
61MP0002084_abnormal_developmental_patter1.21104421
62MP0006292_abnormal_olfactory_placode1.20327024
63MP0005253_abnormal_eye_physiology1.20162858
64MP0005389_reproductive_system_phenotype1.19965956
65MP0003806_abnormal_nucleotide_metabolis1.19499350
66MP0000383_abnormal_hair_follicle1.18850200
67MP0002102_abnormal_ear_morphology1.18790202
68MP0001672_abnormal_embryogenesis/_devel1.18459888
69MP0005380_embryogenesis_phenotype1.18459888
70MP0003121_genomic_imprinting1.17371954
71MP0002019_abnormal_tumor_incidence1.16626372
72MP0005171_absent_coat_pigmentation1.14819967
73MP0001529_abnormal_vocalization1.14049150
74MP0002938_white_spotting1.13122420
75MP0000778_abnormal_nervous_system1.10910656
76MP0008995_early_reproductive_senescence1.09270108
77MP0001324_abnormal_eye_pigmentation1.06126134
78MP0002234_abnormal_pharynx_morphology1.05783864
79MP0002398_abnormal_bone_marrow1.04224458
80MP0005195_abnormal_posterior_eye1.03991120
81MP0003984_embryonic_growth_retardation1.03427067
82MP0000372_irregular_coat_pigmentation1.01829130
83MP0003938_abnormal_ear_development1.00103524
84MP0002088_abnormal_embryonic_growth/wei0.99147798
85MP0002736_abnormal_nociception_after0.98846997
86MP0004885_abnormal_endolymph0.98676446
87MP0004197_abnormal_fetal_growth/weight/0.97545652
88MP0003755_abnormal_palate_morphology0.97278135
89MP0004142_abnormal_muscle_tone0.96262186
90MP0002095_abnormal_skin_pigmentation0.95995013
91MP0002734_abnormal_mechanical_nocicepti0.95676057
92MP0003122_maternal_imprinting0.94486782
93MP0003890_abnormal_embryonic-extraembry0.93447283
94MP0008789_abnormal_olfactory_epithelium0.92623417
95MP0005646_abnormal_pituitary_gland0.92394140
96MP0004133_heterotaxia0.92073649
97MP0002752_abnormal_somatic_nervous0.91065429
98MP0009250_abnormal_appendicular_skeleto0.91052106
99MP0004742_abnormal_vestibular_system0.90593847
100MP0002116_abnormal_craniofacial_bone0.90414431
101MP0006072_abnormal_retinal_apoptosis0.89029319
102MP0009046_muscle_twitch0.87358142
103MP0000358_abnormal_cell_content/0.86081645
104MP0002722_abnormal_immune_system0.85783556
105MP0003942_abnormal_urinary_system0.85347824
106MP0001963_abnormal_hearing_physiology0.85318689
107MP0005083_abnormal_biliary_tract0.85220988
108MP0002086_abnormal_extraembryonic_tissu0.85154897
109MP0002928_abnormal_bile_duct0.84795112
110MP0006276_abnormal_autonomic_nervous0.84226935
111MP0002092_abnormal_eye_morphology0.83921393
112MP0005503_abnormal_tendon_morphology0.83638384
113MP0002272_abnormal_nervous_system0.83396593
114MP0003119_abnormal_digestive_system0.82581000
115MP0002405_respiratory_system_inflammati0.82516745
116MP0005075_abnormal_melanosome_morpholog0.81985423
117MP0009333_abnormal_splenocyte_physiolog0.81182268
118MP0003937_abnormal_limbs/digits/tail_de0.80540292
119MP0000955_abnormal_spinal_cord0.80427836
120MP0005408_hypopigmentation0.80323359
121MP0001486_abnormal_startle_reflex0.80149623
122MP0000534_abnormal_ureter_morphology0.79142919
123MP0000428_abnormal_craniofacial_morphol0.78579949
124MP0005623_abnormal_meninges_morphology0.78472743
125MP0009745_abnormal_behavioral_response0.76590044
126MP0000689_abnormal_spleen_morphology0.75764543
127MP0002557_abnormal_social/conspecific_i0.75749963
128MP0009703_decreased_birth_body0.74845835
129MP0005174_abnormal_tail_pigmentation0.74808347
130MP0000049_abnormal_middle_ear0.74064850
131MP0001119_abnormal_female_reproductive0.73420151
132MP0003186_abnormal_redox_activity0.72924073
133MP0006036_abnormal_mitochondrial_physio0.70408564
134MP0009672_abnormal_birth_weight0.70103822
135MP0005391_vision/eye_phenotype0.70047327
136MP0001919_abnormal_reproductive_system0.69927039
137MP0002429_abnormal_blood_cell0.67888166
138MP0002282_abnormal_trachea_morphology0.67426549
139MP0010352_gastrointestinal_tract_polyps0.66075874
140MP0003315_abnormal_perineum_morphology0.62906597
141MP0005076_abnormal_cell_differentiation0.62592219
142MP0000631_abnormal_neuroendocrine_gland0.62141307
143MP0003943_abnormal_hepatobiliary_system0.60100037
144MP0001286_abnormal_eye_development0.58452484
145MP0005499_abnormal_olfactory_system0.58422775
146MP0005394_taste/olfaction_phenotype0.58422775
147MP0003861_abnormal_nervous_system0.57724981
148MP0001853_heart_inflammation0.57569460
149MP0001986_abnormal_taste_sensitivity0.57105887
150MP0002638_abnormal_pupillary_reflex0.56790966
151MP0002697_abnormal_eye_size0.55293989
152MP0001944_abnormal_pancreas_morphology0.52936848
153MP0001915_intracranial_hemorrhage0.52912382
154MP0005636_abnormal_mineral_homeostasis0.52380402
155MP0003718_maternal_effect0.51201394

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.96942012
2Abnormal ciliary motility (HP:0012262)8.44143560
3Rhinitis (HP:0012384)7.37702033
4Abnormal respiratory epithelium morphology (HP:0012253)7.06658850
5Abnormal respiratory motile cilium morphology (HP:0005938)7.06658850
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.61139599
7Absent/shortened dynein arms (HP:0200106)6.61139599
8Chronic bronchitis (HP:0004469)5.93935487
9Bronchiectasis (HP:0002110)4.77075543
10Nasal polyposis (HP:0100582)4.41316151
11Bronchitis (HP:0012387)3.74100588
12Abnormality of the heme biosynthetic pathway (HP:0010472)3.74054931
13Pancreatic fibrosis (HP:0100732)3.66721349
14Abnormal number of erythroid precursors (HP:0012131)3.55508678
15Nephronophthisis (HP:0000090)3.53978941
16Abnormality of the nasal mucosa (HP:0000433)3.51822627
17True hermaphroditism (HP:0010459)3.48096991
18Abnormality of cells of the erythroid lineage (HP:0012130)3.43481683
19Recurrent sinusitis (HP:0011108)3.40756699
2011 pairs of ribs (HP:0000878)3.05221988
21Abnormality of midbrain morphology (HP:0002418)3.00777538
22Molar tooth sign on MRI (HP:0002419)3.00777538
23Pancreatic cysts (HP:0001737)2.91047380
24Supernumerary spleens (HP:0009799)2.66408292
25Infertility (HP:0000789)2.65953345
26Birth length less than 3rd percentile (HP:0003561)2.63460795
27Recurrent otitis media (HP:0000403)2.61807256
28Abnormality of the renal medulla (HP:0100957)2.54292784
29Cystic liver disease (HP:0006706)2.52599046
30Postaxial foot polydactyly (HP:0001830)2.52048465
31Chronic sinusitis (HP:0011109)2.50343046
32Tubulointerstitial nephritis (HP:0001970)2.44094296
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.41270610
34Abnormality of the anterior horn cell (HP:0006802)2.38366429
35Degeneration of anterior horn cells (HP:0002398)2.38366429
36Facial cleft (HP:0002006)2.36180192
37Recurrent bronchitis (HP:0002837)2.27543989
38Median cleft lip (HP:0000161)2.26711391
39Selective tooth agenesis (HP:0001592)2.26498528
40Chromsome breakage (HP:0040012)2.25598915
41Reticulocytopenia (HP:0001896)2.24994560
42Occipital encephalocele (HP:0002085)2.24898016
43Abnormal biliary tract physiology (HP:0012439)2.17747514
44Bile duct proliferation (HP:0001408)2.17747514
45Abnormality of abdominal situs (HP:0011620)2.17599691
46Abdominal situs inversus (HP:0003363)2.17599691
47Sloping forehead (HP:0000340)2.15060695
48Fibular hypoplasia (HP:0003038)2.12843619
49Anencephaly (HP:0002323)2.11437346
50Furrowed tongue (HP:0000221)2.10475588
51Abnormality of chromosome stability (HP:0003220)2.09967722
52Impulsivity (HP:0100710)2.09521248
53Septo-optic dysplasia (HP:0100842)2.08990815
54Oligodactyly (hands) (HP:0001180)2.07588628
55Nephrogenic diabetes insipidus (HP:0009806)2.07005044
56Aplastic anemia (HP:0001915)2.06788903
57Preaxial hand polydactyly (HP:0001177)2.06347130
58Medial flaring of the eyebrow (HP:0010747)2.04202658
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04132315
60Optic nerve coloboma (HP:0000588)2.03525608
61Congenital hepatic fibrosis (HP:0002612)2.01355890
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.0360096
63Acute necrotizing encephalopathy (HP:0006965)1.97214641
64Poikilocytosis (HP:0004447)1.95471797
65Tubular atrophy (HP:0000092)1.94434114
66Abnormal spermatogenesis (HP:0008669)1.91513646
67Missing ribs (HP:0000921)1.91498342
68Type II lissencephaly (HP:0007260)1.91335202
69Genital tract atresia (HP:0001827)1.91110812
70Volvulus (HP:0002580)1.90045526
71Sclerocornea (HP:0000647)1.89649735
72Meckel diverticulum (HP:0002245)1.88165712
73Abnormality of the labia minora (HP:0012880)1.87686166
74Abnormality of the preputium (HP:0100587)1.85123625
75Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83600526
76Male infertility (HP:0003251)1.83058201
77Vaginal atresia (HP:0000148)1.83023984
78Tubulointerstitial abnormality (HP:0001969)1.81987941
79Aplasia/Hypoplasia of the uvula (HP:0010293)1.81733188
80Anophthalmia (HP:0000528)1.79397406
81Poor coordination (HP:0002370)1.78534198
82Oculomotor apraxia (HP:0000657)1.78426399
83Pallor (HP:0000980)1.77505918
84Abnormality of the ileum (HP:0001549)1.76055940
85Oral leukoplakia (HP:0002745)1.75580925
86Breast hypoplasia (HP:0003187)1.74983446
87Abnormality of reticulocytes (HP:0004312)1.74591644
88Holoprosencephaly (HP:0001360)1.74263531
89Aganglionic megacolon (HP:0002251)1.73875288
90Ectopic kidney (HP:0000086)1.73167640
91Aplasia/Hypoplasia of the spleen (HP:0010451)1.72982885
92Myelodysplasia (HP:0002863)1.72771552
93Acute encephalopathy (HP:0006846)1.70379766
94Chronic hepatic failure (HP:0100626)1.70079098
95Increased nuchal translucency (HP:0010880)1.69012097
96Prominent nose (HP:0000448)1.68698414
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.67731084
98Small intestinal stenosis (HP:0012848)1.66680000
99Duodenal stenosis (HP:0100867)1.66680000
100Bifid tongue (HP:0010297)1.66519870
101Abnormal number of incisors (HP:0011064)1.65880605
102Bone marrow hypocellularity (HP:0005528)1.65009869
103Abnormal mitochondria in muscle tissue (HP:0008316)1.64787454
104Medulloblastoma (HP:0002885)1.64010069
105Broad distal phalanx of finger (HP:0009836)1.63831057
106Abnormality of the renal cortex (HP:0011035)1.63361898
107Narrow forehead (HP:0000341)1.62308096
108Maternal diabetes (HP:0009800)1.62203204
109Short middle phalanx of the 5th finger (HP:0004220)1.61925570
110Congenital primary aphakia (HP:0007707)1.61496834
111Patellar aplasia (HP:0006443)1.60187278
112Asplenia (HP:0001746)1.60146798
113Nephroblastoma (Wilms tumor) (HP:0002667)1.55247490
114Triphalangeal thumb (HP:0001199)1.55021451
115Oligodactyly (HP:0012165)1.54067350
116Male pseudohermaphroditism (HP:0000037)1.52077043
117Progressive macrocephaly (HP:0004481)1.51827524
118Esophageal atresia (HP:0002032)1.51014264
119Postaxial hand polydactyly (HP:0001162)1.50295490
120Cerebellar dysplasia (HP:0007033)1.50071935
121Mitochondrial inheritance (HP:0001427)1.49122299
122Multicystic kidney dysplasia (HP:0000003)1.48946938
123Macrocytic anemia (HP:0001972)1.48730783
124Oligohydramnios (HP:0001562)1.48574248
125Gait imbalance (HP:0002141)1.48437412
126High pitched voice (HP:0001620)1.48242107
127Prominent nasal bridge (HP:0000426)1.48202087
128Abnormality of the carotid arteries (HP:0005344)1.47894505
129Short ribs (HP:0000773)1.47378593
130Astigmatism (HP:0000483)1.47129357
131Aplasia/Hypoplasia of the sternum (HP:0006714)1.46854764
132Reticulocytosis (HP:0001923)1.46240003
133Absent thumb (HP:0009777)1.45853583
134Stage 5 chronic kidney disease (HP:0003774)1.44134925
135Dandy-Walker malformation (HP:0001305)1.42969019
136Polydipsia (HP:0001959)1.42508886
137Abnormal drinking behavior (HP:0030082)1.42508886
138Congenital stationary night blindness (HP:0007642)1.41776840
139Congenital, generalized hypertrichosis (HP:0004540)1.41643196
140Abnormality of the pons (HP:0007361)1.41471066

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.00510751
2WEE14.45086285
3PNCK3.56170481
4BUB13.40668529
5NEK23.05323334
6VRK12.84853035
7MAPK152.68738886
8EIF2AK12.64589878
9PDK32.51706024
10PDK42.51706024
11DYRK32.30441328
12SRPK12.28531417
13PASK2.25500483
14BRSK22.22520097
15TTK2.12354604
16WNK31.98945608
17TLK11.96884036
18ATR1.87279848
19RPS6KA41.80948094
20BMPR1B1.75681868
21PLK11.72722438
22ACVR1B1.67758815
23CDK121.65553670
24MKNK11.62376682
25MKNK21.59985072
26AURKB1.58515957
27STK161.52118675
28STK101.52060682
29CCNB11.51983811
30NME11.49492001
31PLK41.49259225
32BRSK11.48705919
33WNK41.47599779
34VRK21.40767120
35CHEK21.39580881
36SCYL21.38962731
37TNIK1.38934908
38EIF2AK31.36577926
39INSRR1.36231705
40CHEK11.35713912
41CDK71.34371405
42PLK31.32219817
43TESK11.29760046
44AURKA1.21661892
45ATM1.16502039
46CASK1.14234445
47TSSK61.13234218
48NME21.13039265
49STK41.06748986
50MAP3K101.06672266
51PDK21.05979196
52CDK41.05534536
53NEK11.04665398
54TAF11.03653446
55MAP3K41.01264858
56EEF2K0.92354481
57PLK20.91907987
58MAPK130.89240345
59MAP3K80.86620526
60TESK20.85393321
61MAP4K20.84189271
62AKT30.84004964
63CDK20.81910393
64NTRK30.79233690
65CDK80.78048284
66DYRK20.77743026
67MAP4K10.77344611
68RPS6KA50.77312408
69STK38L0.76786504
70BRD40.75373484
71BCR0.75236025
72ADRBK20.74695714
73STK390.74204582
74CSNK2A20.72908693
75PIM20.71304674
76PIM10.70824162
77NUAK10.69940946
78CDK10.69858909
79PRKCG0.69215553
80CSNK2A10.68984551
81ERBB30.68382930
82EPHA20.67997610
83ADRBK10.66641182
84MAPKAPK30.66417632
85CDK30.66406831
86PTK2B0.65667173
87CDK60.64635802
88STK30.58865890
89MST40.58370891
90PRKDC0.58016148
91MAP3K20.57491871
92CLK10.56983127
93RPS6KB20.56370079
94TGFBR10.56004932
95ZAK0.55239219
96CDK190.52618729
97TEC0.52228223
98STK240.50926434
99FRK0.49096111
100BTK0.46122955
101PAK20.45975872
102PINK10.44847392
103HIPK20.43297767
104LRRK20.43022989
105DYRK1B0.40546987
106NEK60.40369804
107KDR0.40305807
108PRKD30.38499908
109MAP2K70.37677277
110TRIM280.37485555
111PAK10.37014366
112UHMK10.35890619
113EPHB20.35714590
114FLT30.35159996
115BRAF0.35125560
116ICK0.34307404
117PAK40.34295188
118MELK0.34241299
119MUSK0.33854039
120RPS6KC10.33451210
121RPS6KL10.33451210
122GRK10.33287116
123YES10.33085000
124CSNK1E0.32979770
125EIF2AK20.32176399
126MAPK140.31949438
127CAMK2A0.31776569
128ABL20.31711132
129MAPKAPK20.30391089
130ERBB20.30355174
131CSNK1G20.30261013
132MET0.29878423
133PIK3CA0.28340605
134CDK90.27308313
135PRKACA0.27223947
136MTOR0.27137449
137PRKG10.26883606
138RPS6KA60.26612267
139OXSR10.26083707
140SGK10.25801051
141MAPKAPK50.25457044
142RPS6KB10.24671915
143AKT10.24461017
144AKT20.23471308
145GSK3B0.23078872
146TXK0.22104171
147PRKCI0.21362431
148PBK0.20635482
149ITK0.20227839
150RPS6KA10.20020471

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.32285654
2Mismatch repair_Homo sapiens_hsa034304.18887852
3Spliceosome_Homo sapiens_hsa030403.45014036
4Homologous recombination_Homo sapiens_hsa034403.29975556
5Nucleotide excision repair_Homo sapiens_hsa034203.14209166
6Base excision repair_Homo sapiens_hsa034103.11524787
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97308020
8Ribosome_Homo sapiens_hsa030102.93970943
9Cell cycle_Homo sapiens_hsa041102.93962674
10RNA transport_Homo sapiens_hsa030132.87192081
11Fanconi anemia pathway_Homo sapiens_hsa034602.78041686
12Pyrimidine metabolism_Homo sapiens_hsa002402.65189630
13Proteasome_Homo sapiens_hsa030502.49160156
14Non-homologous end-joining_Homo sapiens_hsa034502.47134631
15Basal transcription factors_Homo sapiens_hsa030222.46201583
16RNA polymerase_Homo sapiens_hsa030202.46152383
17RNA degradation_Homo sapiens_hsa030182.06873351
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05273011
19mRNA surveillance pathway_Homo sapiens_hsa030152.02618331
20One carbon pool by folate_Homo sapiens_hsa006702.00291486
21Protein export_Homo sapiens_hsa030601.97772533
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.96600358
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92769386
24Chemical carcinogenesis_Homo sapiens_hsa052041.69330729
25Systemic lupus erythematosus_Homo sapiens_hsa053221.67884395
26Purine metabolism_Homo sapiens_hsa002301.66549337
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65695863
28Huntingtons disease_Homo sapiens_hsa050161.59496170
29Antigen processing and presentation_Homo sapiens_hsa046121.59036868
30Cardiac muscle contraction_Homo sapiens_hsa042601.51893344
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43879863
32p53 signaling pathway_Homo sapiens_hsa041151.36267593
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33908231
34Caffeine metabolism_Homo sapiens_hsa002321.31446713
35Oocyte meiosis_Homo sapiens_hsa041141.28746426
36Nitrogen metabolism_Homo sapiens_hsa009101.25759499
37Propanoate metabolism_Homo sapiens_hsa006401.25171512
38Butanoate metabolism_Homo sapiens_hsa006501.23602249
39Steroid biosynthesis_Homo sapiens_hsa001001.20916618
40Tyrosine metabolism_Homo sapiens_hsa003501.17923432
41Selenocompound metabolism_Homo sapiens_hsa004501.17318802
42beta-Alanine metabolism_Homo sapiens_hsa004101.16690006
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15764327
44Histidine metabolism_Homo sapiens_hsa003401.14613259
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13935169
46Retinol metabolism_Homo sapiens_hsa008301.11894600
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09905785
48Nicotine addiction_Homo sapiens_hsa050331.07238323
49Viral carcinogenesis_Homo sapiens_hsa052031.07180597
50Epstein-Barr virus infection_Homo sapiens_hsa051691.04590280
51Phenylalanine metabolism_Homo sapiens_hsa003601.04521923
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04288285
53Herpes simplex infection_Homo sapiens_hsa051680.98394803
54Vitamin B6 metabolism_Homo sapiens_hsa007500.98150660
55Alcoholism_Homo sapiens_hsa050340.93481626
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93183932
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91775130
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85351699
59HTLV-I infection_Homo sapiens_hsa051660.84469545
60Peroxisome_Homo sapiens_hsa041460.82359732
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.79013770
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.78437198
63Primary immunodeficiency_Homo sapiens_hsa053400.78088275
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77593182
65N-Glycan biosynthesis_Homo sapiens_hsa005100.77431188
66Olfactory transduction_Homo sapiens_hsa047400.76902865
67Pentose phosphate pathway_Homo sapiens_hsa000300.74515987
68Parkinsons disease_Homo sapiens_hsa050120.72919049
69Taste transduction_Homo sapiens_hsa047420.72836349
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71877034
71Tryptophan metabolism_Homo sapiens_hsa003800.71733588
72Fatty acid degradation_Homo sapiens_hsa000710.69921392
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.68614083
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63507100
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61837300
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59257565
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.59038941
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58206343
79Pyruvate metabolism_Homo sapiens_hsa006200.55475402
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53681560
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52868473
82Fatty acid elongation_Homo sapiens_hsa000620.52729391
83Sulfur relay system_Homo sapiens_hsa041220.52145029
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50195818
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48446686
86Hematopoietic cell lineage_Homo sapiens_hsa046400.47069676
87Tight junction_Homo sapiens_hsa045300.47036270
88Cocaine addiction_Homo sapiens_hsa050300.44970971
89Thyroid cancer_Homo sapiens_hsa052160.44197037
90Oxidative phosphorylation_Homo sapiens_hsa001900.40843220
91Measles_Homo sapiens_hsa051620.40269405
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39109295
93Basal cell carcinoma_Homo sapiens_hsa052170.37516528
94Hepatitis B_Homo sapiens_hsa051610.36527580
95Arginine and proline metabolism_Homo sapiens_hsa003300.35493395
96Glutathione metabolism_Homo sapiens_hsa004800.34647916
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34355577
98Insulin secretion_Homo sapiens_hsa049110.33423202
99MicroRNAs in cancer_Homo sapiens_hsa052060.33038976
100Vitamin digestion and absorption_Homo sapiens_hsa049770.32777090
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32437376
102Small cell lung cancer_Homo sapiens_hsa052220.32401917
103Regulation of autophagy_Homo sapiens_hsa041400.30412682
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30176615
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29961298
106Glucagon signaling pathway_Homo sapiens_hsa049220.29458843
107Serotonergic synapse_Homo sapiens_hsa047260.28663715
108Circadian rhythm_Homo sapiens_hsa047100.28380080
109Linoleic acid metabolism_Homo sapiens_hsa005910.28334782
110Colorectal cancer_Homo sapiens_hsa052100.28240600
111Legionellosis_Homo sapiens_hsa051340.28020986
112Asthma_Homo sapiens_hsa053100.27660546
113Hedgehog signaling pathway_Homo sapiens_hsa043400.25798941
114Circadian entrainment_Homo sapiens_hsa047130.25417348
115Alzheimers disease_Homo sapiens_hsa050100.25328771
116Salivary secretion_Homo sapiens_hsa049700.25062885
117Wnt signaling pathway_Homo sapiens_hsa043100.25043618
118Dorso-ventral axis formation_Homo sapiens_hsa043200.23857060
119Lysine degradation_Homo sapiens_hsa003100.23601007
120Metabolic pathways_Homo sapiens_hsa011000.22682529
121Biosynthesis of amino acids_Homo sapiens_hsa012300.21720820
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21077342
123Prostate cancer_Homo sapiens_hsa052150.20239418
124Apoptosis_Homo sapiens_hsa042100.19801175
125Renin-angiotensin system_Homo sapiens_hsa046140.19173823
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18360712
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16437736
128Chronic myeloid leukemia_Homo sapiens_hsa052200.16406885
129Folate biosynthesis_Homo sapiens_hsa007900.16019362
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15812475
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15618586
132T cell receptor signaling pathway_Homo sapiens_hsa046600.15173785
133Acute myeloid leukemia_Homo sapiens_hsa052210.14690085
134TGF-beta signaling pathway_Homo sapiens_hsa043500.13998058
135Type I diabetes mellitus_Homo sapiens_hsa049400.13971042
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.13925949
137Pathways in cancer_Homo sapiens_hsa052000.12670011
138Notch signaling pathway_Homo sapiens_hsa043300.11697674
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10302642
140Influenza A_Homo sapiens_hsa051640.09398673
141Arachidonic acid metabolism_Homo sapiens_hsa005900.07694394
142Carbon metabolism_Homo sapiens_hsa012000.06296489
143Viral myocarditis_Homo sapiens_hsa054160.05405078
144Phototransduction_Homo sapiens_hsa047440.04852095
145Intestinal immune network for IgA production_Homo sapiens_hsa046720.04310694
146Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03993020
147Hippo signaling pathway_Homo sapiens_hsa043900.03753965
148Allograft rejection_Homo sapiens_hsa053300.03559211

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