MNT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.99326810
2positive regulation of CREB transcription factor activity (GO:0032793)4.54052613
3histone H4-K12 acetylation (GO:0043983)4.32817715
4intracellular estrogen receptor signaling pathway (GO:0030520)4.31071213
5heterochromatin organization (GO:0070828)4.03281017
6negative regulation of cAMP-mediated signaling (GO:0043951)3.93139770
7positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.90025643
8regulation of integrin activation (GO:0033623)3.75051440
9positive regulation of histone deacetylation (GO:0031065)3.72342946
10regulation of hippo signaling (GO:0035330)3.48876131
11cell-cell junction maintenance (GO:0045217)3.48130404
12dosage compensation (GO:0007549)3.43497127
13trophectodermal cell differentiation (GO:0001829)3.41205866
14negative regulation of glial cell proliferation (GO:0060253)3.40407951
15regulation of gamma-delta T cell differentiation (GO:0045586)3.38134818
16regulation of NFAT protein import into nucleus (GO:0051532)3.36803794
17embryonic process involved in female pregnancy (GO:0060136)3.31453010
18mRNA stabilization (GO:0048255)3.31052348
19RNA stabilization (GO:0043489)3.31052348
20apoptotic process involved in morphogenesis (GO:0060561)3.29296448
21establishment of apical/basal cell polarity (GO:0035089)3.21774613
22positive thymic T cell selection (GO:0045059)3.19401761
23mannose metabolic process (GO:0006013)3.16976302
24regulation of translational fidelity (GO:0006450)3.14583218
25positive regulation of gene expression, epigenetic (GO:0045815)3.13603332
26negative regulation of erythrocyte differentiation (GO:0045647)3.10950148
27negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10450091
28negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.08879446
29modulation by symbiont of host immune response (GO:0052553)3.07151414
30positive regulation by symbiont of host defense response (GO:0052509)3.07151414
31modulation by symbiont of host defense response (GO:0052031)3.07151414
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.07151414
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.07151414
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.07151414
35histone H3-K4 trimethylation (GO:0080182)3.05519309
36histone H4-K5 acetylation (GO:0043981)3.03142761
37histone H4-K8 acetylation (GO:0043982)3.03142761
38positive regulation of gamma-delta T cell activation (GO:0046645)3.02463368
39nodal signaling pathway (GO:0038092)3.00536665
40regulation of gamma-delta T cell activation (GO:0046643)2.98521905
41positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.94037079
42regulation of chromatin binding (GO:0035561)2.92047929
43embryonic placenta development (GO:0001892)2.91951520
44glucocorticoid receptor signaling pathway (GO:0042921)2.91436027
45regulation of gene silencing by RNA (GO:0060966)2.90362615
46regulation of posttranscriptional gene silencing (GO:0060147)2.90362615
47regulation of gene silencing by miRNA (GO:0060964)2.90362615
48positive regulation of protein deacetylation (GO:0090312)2.89696817
49response to muramyl dipeptide (GO:0032495)2.87307824
50establishment of monopolar cell polarity (GO:0061162)2.86969449
51establishment or maintenance of monopolar cell polarity (GO:0061339)2.86969449
52NLS-bearing protein import into nucleus (GO:0006607)2.85787353
53leukocyte aggregation (GO:0070486)2.84714105
54protein-DNA complex disassembly (GO:0032986)2.82569608
55nucleosome disassembly (GO:0006337)2.82569608
56regulation of RNA export from nucleus (GO:0046831)2.82271661
57response to laminar fluid shear stress (GO:0034616)2.81991359
58histone H4-K16 acetylation (GO:0043984)2.79774903
59cytoplasmic mRNA processing body assembly (GO:0033962)2.79711940
60negative regulation of histone methylation (GO:0031061)2.78611213
61negative regulation of cell killing (GO:0031342)2.78341086
62negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.78341086
63cell migration in hindbrain (GO:0021535)2.77905596
64tolerance induction (GO:0002507)2.76914631
65maternal placenta development (GO:0001893)2.75897648
66cellular extravasation (GO:0045123)2.72927787
67response to peptidoglycan (GO:0032494)2.71107999
68positive T cell selection (GO:0043368)2.69543780
69negative regulation of RNA splicing (GO:0033119)2.69150886
70negative regulation of cell size (GO:0045792)2.68122435
71activated T cell proliferation (GO:0050798)2.67748120
72positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.66620091
73cell junction maintenance (GO:0034331)2.66143262
74negative regulation of protein oligomerization (GO:0032460)2.65691639
75regulation of glial cell proliferation (GO:0060251)2.63381300
76regulation of ARF GTPase activity (GO:0032312)2.62753579
77regulation of protein homooligomerization (GO:0032462)2.62541778
78negative regulation of mRNA metabolic process (GO:1903312)2.62425954
79positive regulation of SMAD protein import into nucleus (GO:0060391)2.62410828
80negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.62362170
81negative regulation of mRNA processing (GO:0050686)2.59558431
82dendritic spine morphogenesis (GO:0060997)2.58698657
83peptidyl-lysine dimethylation (GO:0018027)2.56907834
84activation of JUN kinase activity (GO:0007257)2.56165991
85regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.54817814
86adherens junction assembly (GO:0034333)2.54227596
87adaptation of signaling pathway (GO:0023058)2.54059182
88thymic T cell selection (GO:0045061)2.53286086
89behavioral response to nicotine (GO:0035095)2.52918545
90epithelial cell fate commitment (GO:0072148)2.52386808
91negative regulation of interleukin-1 production (GO:0032692)2.51822286
92regulation of early endosome to late endosome transport (GO:2000641)2.51324461
93positive regulation by host of viral transcription (GO:0043923)2.50484516
94apoptotic process involved in development (GO:1902742)2.48459495
95macrophage activation involved in immune response (GO:0002281)2.47495944
96T cell selection (GO:0045058)2.47080069
97histone H3-K4 methylation (GO:0051568)2.46727848
98primitive streak formation (GO:0090009)2.46076304
99negative regulation of cell cycle arrest (GO:0071157)2.45857074
100regulation of nucleobase-containing compound transport (GO:0032239)2.45722129
101regulation of mRNA stability (GO:0043488)2.45176227
102negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.45021305
103regulation of B cell receptor signaling pathway (GO:0050855)2.44445677
104polarized epithelial cell differentiation (GO:0030859)2.44082301
105negative regulation of T cell mediated immunity (GO:0002710)2.43226673
106regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43100447
107histone H3-K9 modification (GO:0061647)2.42938832
108anatomical structure regression (GO:0060033)2.42937215
109neural tube closure (GO:0001843)2.42742927
110negative regulation of Rho protein signal transduction (GO:0035024)2.42146752
111retinoic acid receptor signaling pathway (GO:0048384)2.41144872
112negative regulation of viral release from host cell (GO:1902187)2.40643524
1133-UTR-mediated mRNA stabilization (GO:0070935)2.40249535
114planar cell polarity pathway involved in neural tube closure (GO:0090179)2.40179310
115negative regulation of lymphocyte mediated immunity (GO:0002707)2.39969842
116mitotic G1 DNA damage checkpoint (GO:0031571)2.39910699
117positive regulation of protein homooligomerization (GO:0032464)2.38296023
118histone H3 acetylation (GO:0043966)2.38222540
119intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.36779573
120regulation of ARF protein signal transduction (GO:0032012)2.36757825
121convergent extension (GO:0060026)2.36740942
122tube closure (GO:0060606)2.36616108
123regulation of SMAD protein import into nucleus (GO:0060390)2.35994852
124proline biosynthetic process (GO:0006561)2.35974326
125negative regulation of interleukin-6 production (GO:0032715)2.35160189
126endothelial cell chemotaxis (GO:0035767)2.34773811
127nuclear pore complex assembly (GO:0051292)2.33679599
128antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.33307776
129cytoskeletal anchoring at plasma membrane (GO:0007016)2.33161796
130negative thymic T cell selection (GO:0045060)2.33005038
131regulation of protein deacetylation (GO:0090311)2.32608897
132negative regulation of granulocyte differentiation (GO:0030853)2.32591763
133regulation of histone deacetylation (GO:0031063)2.32268689
134negative T cell selection (GO:0043383)2.31752413
135mRNA cleavage (GO:0006379)2.31301205
136labyrinthine layer blood vessel development (GO:0060716)2.30738981
137regulation of RNA stability (GO:0043487)2.29762463
138positive regulation of fatty acid beta-oxidation (GO:0032000)2.29654540
139response to interleukin-15 (GO:0070672)2.28706698
140focal adhesion assembly (GO:0048041)2.28577772
141cell-substrate adherens junction assembly (GO:0007045)2.28577772
142negative regulation of interleukin-8 production (GO:0032717)2.28051074
143ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.27592072
144detection of other organism (GO:0098543)2.27512867
145stress fiber assembly (GO:0043149)2.27392955
146negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.26895320
147detection of bacterium (GO:0016045)2.26809691
148signal complex assembly (GO:0007172)2.25492898
149antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.25373873
150histone H3-K36 demethylation (GO:0070544)2.24693945
151antigen processing and presentation of endogenous antigen (GO:0019883)2.23895549
152cardiovascular system development (GO:0072358)2.20915651
153activation of MAPKKK activity (GO:0000185)2.17817783
154positive regulation of triglyceride biosynthetic process (GO:0010867)2.16736273
155RNA destabilization (GO:0050779)2.15833475
156regulation of glycogen (starch) synthase activity (GO:2000465)2.15682902
157positive regulation of Rap GTPase activity (GO:0032854)2.14223844
158positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.13285907
159cerebellar Purkinje cell differentiation (GO:0021702)2.13211029
160positive regulation of fatty acid oxidation (GO:0046321)2.13099981
161cellular response to interleukin-15 (GO:0071350)2.12553186
162negative regulation of leukocyte mediated immunity (GO:0002704)2.09938290
163positive regulation of protein kinase C signaling (GO:0090037)2.09700315
164leukocyte migration involved in inflammatory response (GO:0002523)2.09492682
165B cell receptor signaling pathway (GO:0050853)2.09023047
166negative regulation of interleukin-1 beta production (GO:0032691)2.07308006
167negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.05820515
168negative regulation of T-helper cell differentiation (GO:0045623)2.05820515
169positive regulation of defense response to virus by host (GO:0002230)2.04347283
170regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.04188939
171regulation of mast cell activation (GO:0033003)2.04185858
172antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.03028880
173detection of external biotic stimulus (GO:0098581)2.02697954
174negative regulation of interleukin-12 production (GO:0032695)2.02580107
175phosphatidylglycerol biosynthetic process (GO:0006655)2.01557051
176head development (GO:0060322)2.01279376
177regulation of fatty acid beta-oxidation (GO:0031998)2.00878626
178modulation by virus of host process (GO:0019054)2.00552898
179opioid receptor signaling pathway (GO:0038003)2.00006914
180detection of molecule of bacterial origin (GO:0032490)1.98561705
181regulation of translation, ncRNA-mediated (GO:0045974)1.96883485
182negative regulation of translation involved in gene silencing by miRNA (GO:0035278)1.96883485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYC_22102868_ChIP-Seq_BL_Human3.78803358
2EZH2_22144423_ChIP-Seq_EOC_Human3.59942435
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.07169573
4VDR_21846776_ChIP-Seq_THP-1_Human2.97388780
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.89689951
6* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.86084962
7* TCF7_22412390_ChIP-Seq_EML_Mouse2.77317485
8* KDM2B_26808549_Chip-Seq_DND41_Human2.69513609
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.54329333
10DROSHA_22980978_ChIP-Seq_HELA_Human2.49107468
11* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.49056908
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.45164819
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.41045846
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.40686009
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.40686009
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.40686009
17* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.40519229
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.39929900
19* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.35578889
20ZFP281_18757296_ChIP-ChIP_E14_Mouse2.25881969
21LXR_22292898_ChIP-Seq_THP-1_Human2.21702392
22* ELK3_25401928_ChIP-Seq_HUVEC_Human2.21634342
23* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.12343816
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.06658207
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06360219
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.01875289
27KDM2B_26808549_Chip-Seq_K562_Human1.90033388
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.89721451
29E2F7_22180533_ChIP-Seq_HELA_Human1.86831882
30* KDM2B_26808549_Chip-Seq_JURKAT_Human1.86429119
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76446382
32UTX_26944678_Chip-Seq_JUKART_Human1.74301381
33* MAF_26560356_Chip-Seq_TH1_Human1.73585789
34* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.73045063
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72848570
36RACK7_27058665_Chip-Seq_MCF-7_Human1.70263939
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68902256
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.68777327
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68716557
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.65982175
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60460788
42CTCF_27219007_Chip-Seq_Bcells_Human1.60394523
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60275512
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.59999423
45SMC4_20622854_ChIP-Seq_HELA_Human1.59188634
46* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.58369483
47ZNF263_19887448_ChIP-Seq_K562_Human1.57126890
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57069060
49VDR_24763502_ChIP-Seq_THP-1_Human1.56913695
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56373210
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.55742574
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.54639855
53SCL_19346495_ChIP-Seq_HPC-7_Human1.51559937
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.51082650
55RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.50658999
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48499637
57* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45757850
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45271086
59* NCOR1_26117541_ChIP-Seq_K562_Human1.45031018
60* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44589193
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44192929
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42246854
63NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.42038558
64OCT4_19829295_ChIP-Seq_ESCs_Human1.39817011
65RUNX_20019798_ChIP-Seq_JUKART_Human1.37012665
66REST_21632747_ChIP-Seq_MESCs_Mouse1.36291876
67* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35468548
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34069413
69BCL6_27268052_Chip-Seq_Bcells_Human1.33579175
70SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33502273
71* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.33289453
72BCOR_27268052_Chip-Seq_Bcells_Human1.32808467
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32222034
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32177531
75* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31653742
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.31434934
77* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30668705
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30429811
79CREB1_26743006_Chip-Seq_LNCaP_Human1.30299612
80MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.29920744
81NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.29704519
82* MAF_26560356_Chip-Seq_TH2_Human1.29574711
83E2F1_20622854_ChIP-Seq_HELA_Human1.29506914
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29341208
85TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.28692540
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28477738
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28153934
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27990978
89TP63_17297297_ChIP-ChIP_HaCaT_Human1.27660891
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26399487
91* RUNX1_22412390_ChIP-Seq_EML_Mouse1.26362624
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24989637
93RARB_27405468_Chip-Seq_BRAIN_Mouse1.24854737
94SPI1_23127762_ChIP-Seq_K562_Human1.24737968
95POU5F1_16518401_ChIP-PET_MESCs_Mouse1.24575406
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23836193
97* ATF3_27146783_Chip-Seq_COLON_Human1.22276801
98TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21013632
99* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20915023
100GATA1_19941827_ChIP-Seq_MEL_Mouse1.20054908
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.18636649
102* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18401661
103RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18300624
104EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18300624
105BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17823916
106* TET1_21451524_ChIP-Seq_MESCs_Mouse1.16723461
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16389052
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16368562
109SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16048458
110P68_20966046_ChIP-Seq_HELA_Human1.15583698
111MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15333265
112PHF8_20622854_ChIP-Seq_HELA_Human1.13202704
113TP63_22573176_ChIP-Seq_HFKS_Human1.12979396
114* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12777315
115REST_18959480_ChIP-ChIP_MESCs_Mouse1.12356723
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12179728
117TP53_22127205_ChIP-Seq_IMR90_Human1.11820269
118MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11551371
119TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10705096
120SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10519101
121SA1_27219007_Chip-Seq_ERYTHROID_Human1.09940431
122STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08499297
123* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08223978
124FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07791260
125BP1_19119308_ChIP-ChIP_Hs578T_Human1.07124379
126ELF1_20517297_ChIP-Seq_JURKAT_Human1.06980057
127NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06957125
128* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06938623
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06600593
130* MYB_26560356_Chip-Seq_TH1_Human1.06070001
131NANOG_21062744_ChIP-ChIP_HESCs_Human1.05950791
132* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05923261
133SA1_27219007_Chip-Seq_Bcells_Human1.05615594
134KLF4_19829295_ChIP-Seq_ESCs_Human1.05596847
135* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05405116
136RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04983232
137* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04968394
138* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04832342
139PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04360279
140RUNX1_27514584_Chip-Seq_MCF-7_Human1.03948605
141EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03860143
142EED_16625203_ChIP-ChIP_MESCs_Mouse1.03670692
143CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03098959
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01792872
145ERA_21632823_ChIP-Seq_H3396_Human1.01690908
146SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01058743
147RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00456002
148EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99720671
149ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99598150
150* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99513364
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99431285
152TP53_20018659_ChIP-ChIP_R1E_Mouse0.99278607
153* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96921196
154SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96776777
155SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95842327
156CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95419047
157SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93637338

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow3.40738126
2MP0005076_abnormal_cell_differentiation3.15336105
3MP0003705_abnormal_hypodermis_morpholog2.86905789
4MP0010352_gastrointestinal_tract_polyps2.83925919
5MP0008961_abnormal_basal_metabolism2.78687096
6MP0002653_abnormal_ependyma_morphology2.70431974
7MP0005423_abnormal_somatic_nervous2.55522822
8MP0001986_abnormal_taste_sensitivity2.48198758
9MP0003724_increased_susceptibility_to2.42429938
10MP0008057_abnormal_DNA_replication2.27227280
11MP0003303_peritoneal_inflammation2.25931957
12MP0004859_abnormal_synaptic_plasticity2.25901137
13MP0010030_abnormal_orbit_morphology2.16352553
14MP0004130_abnormal_muscle_cell2.14956711
15MP0004808_abnormal_hematopoietic_stem2.10172360
16MP0001849_ear_inflammation2.08671145
17MP0001502_abnormal_circadian_rhythm2.06843611
18MP0004381_abnormal_hair_follicle2.01155178
19MP0003172_abnormal_lysosome_physiology1.98191035
20MP0005397_hematopoietic_system_phenotyp1.94390902
21MP0001545_abnormal_hematopoietic_system1.94390902
22MP0003635_abnormal_synaptic_transmissio1.82853835
23MP0005377_hearing/vestibular/ear_phenot1.82450992
24MP0003878_abnormal_ear_physiology1.82450992
25MP0003879_abnormal_hair_cell1.80832763
26MP0001968_abnormal_touch/_nociception1.78426861
27MP0003566_abnormal_cell_adhesion1.77961941
28MP0003283_abnormal_digestive_organ1.72571830
29MP0002063_abnormal_learning/memory/cond1.71647299
30MP0005409_darkened_coat_color1.71505570
31MP0004858_abnormal_nervous_system1.68216395
32MP0002396_abnormal_hematopoietic_system1.64159423
33MP0001501_abnormal_sleep_pattern1.63930227
34MP0000569_abnormal_digit_pigmentation1.61991543
35MP0002138_abnormal_hepatobiliary_system1.55737584
36MP0009745_abnormal_behavioral_response1.48767648
37MP0003300_gastrointestinal_ulcer1.48546790
38MP0004885_abnormal_endolymph1.48538069
39MP0002419_abnormal_innate_immunity1.48496311
40MP0002877_abnormal_melanocyte_morpholog1.48116350
41MP0002084_abnormal_developmental_patter1.47578220
42MP0002086_abnormal_extraembryonic_tissu1.45888356
43MP0003045_fibrosis1.44095850
44MP0002723_abnormal_immune_serum1.42702003
45MP0003787_abnormal_imprinting1.42632641
46MP0001970_abnormal_pain_threshold1.40119506
47MP0002420_abnormal_adaptive_immunity1.39554686
48MP0002733_abnormal_thermal_nociception1.39413896
49MP0002064_seizures1.39126708
50MP0005257_abnormal_intraocular_pressure1.39004414
51* MP0004197_abnormal_fetal_growth/weight/1.38476093
52MP0000733_abnormal_muscle_development1.38175107
53MP0002735_abnormal_chemical_nociception1.38061312
54MP0001819_abnormal_immune_cell1.37190077
55MP0002572_abnormal_emotion/affect_behav1.36906981
56MP0003119_abnormal_digestive_system1.35914375
57MP0002088_abnormal_embryonic_growth/wei1.34597526
58MP0000490_abnormal_crypts_of1.33910276
59MP0005380_embryogenesis_phenotype1.33653879
60MP0001672_abnormal_embryogenesis/_devel1.33653879
61MP0003984_embryonic_growth_retardation1.32525827
62MP0005671_abnormal_response_to1.31810162
63MP0000685_abnormal_immune_system1.31701913
64MP0004233_abnormal_muscle_weight1.31578274
65MP0002085_abnormal_embryonic_tissue1.31487907
66MP0001835_abnormal_antigen_presentation1.31124146
67MP0000703_abnormal_thymus_morphology1.30848668
68MP0005025_abnormal_response_to1.29585054
69MP0005083_abnormal_biliary_tract1.29319452
70MP0005000_abnormal_immune_tolerance1.29075937
71MP0000350_abnormal_cell_proliferation1.26876403
72MP0005023_abnormal_wound_healing1.26580967
73MP0001533_abnormal_skeleton_physiology1.23582331
74MP0000470_abnormal_stomach_morphology1.22543558
75MP0004510_myositis1.20878639
76MP0002928_abnormal_bile_duct1.19596787
77MP0001486_abnormal_startle_reflex1.19426628
78MP0002398_abnormal_bone_marrow1.19343388
79MP0002925_abnormal_cardiovascular_devel1.18920685
80MP0001348_abnormal_lacrimal_gland1.18832091
81MP0002822_catalepsy1.17226276
82MP0003890_abnormal_embryonic-extraembry1.16736896
83* MP0001697_abnormal_embryo_size1.16538700
84MP0008770_decreased_survivor_rate1.15933226
85MP0000428_abnormal_craniofacial_morphol1.12938865
86MP0003866_abnormal_defecation1.11688162
87MP0001188_hyperpigmentation1.10635465
88MP0001730_embryonic_growth_arrest1.10595719
89MP0005623_abnormal_meninges_morphology1.10422762
90MP0001440_abnormal_grooming_behavior1.09929144
91MP0004742_abnormal_vestibular_system1.09587770
92MP0002405_respiratory_system_inflammati1.09489245
93MP0002272_abnormal_nervous_system1.08976024
94MP0003091_abnormal_cell_migration1.08574818
95MP0004264_abnormal_extraembryonic_tissu1.07930712
96MP0003646_muscle_fatigue1.05725982
97MP0002933_joint_inflammation1.05021774
98MP0005174_abnormal_tail_pigmentation1.04014185
99MP0002722_abnormal_immune_system1.02770132
100MP0010307_abnormal_tumor_latency1.02615463
101MP0001293_anophthalmia1.02604319
102MP0005448_abnormal_energy_balance1.02369670
103MP0000015_abnormal_ear_pigmentation1.01811166
104MP0003763_abnormal_thymus_physiology1.01129003
105MP0004957_abnormal_blastocyst_morpholog1.00618387
106MP0003279_aneurysm0.99773360
107MP0002092_abnormal_eye_morphology0.99439933
108MP0000689_abnormal_spleen_morphology0.99154832
109MP0003115_abnormal_respiratory_system0.98947078
110MP0005394_taste/olfaction_phenotype0.98491032
111MP0005499_abnormal_olfactory_system0.98491032
112MP0001800_abnormal_humoral_immune0.96929051
113MP0006082_CNS_inflammation0.96334886
114MP0003077_abnormal_cell_cycle0.95867109
115MP0002080_prenatal_lethality0.95394911
116* MP0003935_abnormal_craniofacial_develop0.95088937
117MP0003122_maternal_imprinting0.94456808
118MP0008995_early_reproductive_senescence0.94364123
119MP0010630_abnormal_cardiac_muscle0.93730278
120MP0005387_immune_system_phenotype0.93577804
121MP0001790_abnormal_immune_system0.93577804
122MP0003567_abnormal_fetal_cardiomyocyte0.93231854
123MP0003828_pulmonary_edema0.92724438
124MP0003111_abnormal_nucleus_morphology0.92444698
125MP0003436_decreased_susceptibility_to0.91115870
126MP0002932_abnormal_joint_morphology0.89798688
127MP0002067_abnormal_sensory_capabilities0.89564071
128MP0005310_abnormal_salivary_gland0.87713113
129MP0009333_abnormal_splenocyte_physiolog0.86032609
130MP0003453_abnormal_keratinocyte_physiol0.85693850
131MP0000678_abnormal_parathyroid_gland0.85668531
132MP0009046_muscle_twitch0.84889536
133MP0003448_altered_tumor_morphology0.83685919
134MP0004185_abnormal_adipocyte_glucose0.83391263
135MP0000716_abnormal_immune_system0.82846454
136MP0005390_skeleton_phenotype0.82727291
137MP0004947_skin_inflammation0.82364503
138MP0001485_abnormal_pinna_reflex0.81839414
139MP0002557_abnormal_social/conspecific_i0.81617924
140MP0000049_abnormal_middle_ear0.81266179
141MP0000266_abnormal_heart_morphology0.80106038
142MP0002089_abnormal_postnatal_growth/wei0.79795317
143MP0000313_abnormal_cell_death0.79626217
144MP0001784_abnormal_fluid_regulation0.79601815
145* MP0002116_abnormal_craniofacial_bone0.78844517
146MP0006292_abnormal_olfactory_placode0.78501097
147MP0009115_abnormal_fat_cell0.78279206
148MP0001663_abnormal_digestive_system0.77697042
149MP0005167_abnormal_blood-brain_barrier0.77195015
150MP0008569_lethality_at_weaning0.77179760
151MP0000432_abnormal_head_morphology0.76445111
152MP0002429_abnormal_blood_cell0.75908968
153MP0001873_stomach_inflammation0.75519752
154MP0002249_abnormal_larynx_morphology0.75320555
155MP0002882_abnormal_neuron_morphology0.74486415
156MP0002452_abnormal_antigen_presenting0.74186873
157MP0000477_abnormal_intestine_morphology0.73498508
158MP0002998_abnormal_bone_remodeling0.72907150
159MP0009840_abnormal_foam_cell0.72804730
160MP0005551_abnormal_eye_electrophysiolog0.72765972
161MP0000778_abnormal_nervous_system0.72672987
162MP0000955_abnormal_spinal_cord0.72480733
163MP0004043_abnormal_pH_regulation0.70984484
164MP0000230_abnormal_systemic_arterial0.68188305
165MP0005670_abnormal_white_adipose0.68097945
166MP0003123_paternal_imprinting0.67868922
167MP0005646_abnormal_pituitary_gland0.67687602
168MP0002734_abnormal_mechanical_nocicepti0.67166335

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)4.14174023
2Elevated erythrocyte sedimentation rate (HP:0003565)4.03739206
3Progressive cerebellar ataxia (HP:0002073)3.61007166
4Hyperacusis (HP:0010780)3.58273823
5Cerebral aneurysm (HP:0004944)3.43053838
6Myositis (HP:0100614)3.27672157
7Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.09620527
8Abnormality of binocular vision (HP:0011514)3.06332848
9Diplopia (HP:0000651)3.06332848
10Annular pancreas (HP:0001734)2.95895129
11Orchitis (HP:0100796)2.95335601
12Gastrointestinal infarctions (HP:0005244)2.95105222
13Rib fusion (HP:0000902)2.90761337
14Renal duplication (HP:0000075)2.78392558
15Optic neuritis (HP:0100653)2.78102059
16Retrobulbar optic neuritis (HP:0100654)2.78102059
17Eczematoid dermatitis (HP:0000976)2.75066581
18Hypochromic anemia (HP:0001931)2.68429195
19Abnormality of the lower motor neuron (HP:0002366)2.65011978
20Urethral obstruction (HP:0000796)2.63551657
21Peritonitis (HP:0002586)2.60361691
22Clumsiness (HP:0002312)2.59037859
23Type II lissencephaly (HP:0007260)2.54550158
24Stomatitis (HP:0010280)2.52867489
25Ulnar bowing (HP:0003031)2.52161051
26Abnormality of the columella (HP:0009929)2.51907606
27Ependymoma (HP:0002888)2.49213468
28Protruding tongue (HP:0010808)2.43600836
29Abnormality of the astrocytes (HP:0100707)2.41017484
30Astrocytoma (HP:0009592)2.41017484
31Hand muscle atrophy (HP:0009130)2.40420716
32Abnormality of the fingertips (HP:0001211)2.40193829
33Abnormality of the aortic arch (HP:0012303)2.38639180
34Recurrent fungal infections (HP:0002841)2.38163262
35Upper limb amyotrophy (HP:0009129)2.37497538
36Distal upper limb amyotrophy (HP:0007149)2.37497538
37Macroorchidism (HP:0000053)2.37127735
38Genu recurvatum (HP:0002816)2.35624282
39Shallow orbits (HP:0000586)2.35599689
40Increased IgE level (HP:0003212)2.34266402
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.31840502
42Nasal polyposis (HP:0100582)2.21818990
43Congenital stationary night blindness (HP:0007642)2.21379117
44Sleep apnea (HP:0010535)2.20089058
45Cerebellar dysplasia (HP:0007033)2.18140238
46Heterotopia (HP:0002282)2.15059238
47Broad thumb (HP:0011304)2.14197532
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14157602
49Recurrent cutaneous fungal infections (HP:0011370)2.11996293
50Chronic mucocutaneous candidiasis (HP:0002728)2.11996293
51Papilledema (HP:0001085)2.11333300
52Intestinal fistula (HP:0100819)2.09925943
53Recurrent bacterial skin infections (HP:0005406)2.07643908
54Pustule (HP:0200039)2.05904461
55Abnormality of the nasal mucosa (HP:0000433)2.05063589
56Epileptic encephalopathy (HP:0200134)2.04580061
57Stereotypic behavior (HP:0000733)2.03812042
58Hypochromic microcytic anemia (HP:0004840)2.03319487
59Increased density of long bones (HP:0006392)2.02468944
60Neoplasm of the heart (HP:0100544)2.01747832
61Elfin facies (HP:0004428)2.00611839
62Abnormal rod and cone electroretinograms (HP:0008323)1.99601200
63Hemoptysis (HP:0002105)1.99162915
64Skin tags (HP:0010609)1.97822138
65Obstructive sleep apnea (HP:0002870)1.97373813
66Volvulus (HP:0002580)1.97195148
67Cellulitis (HP:0100658)1.96075713
68Segmental peripheral demyelination/remyelination (HP:0003481)1.95197121
69Short humerus (HP:0005792)1.94465609
70Basal cell carcinoma (HP:0002671)1.93688430
71Protrusio acetabuli (HP:0003179)1.92919551
72Increased nuchal translucency (HP:0010880)1.92812111
73Hyperventilation (HP:0002883)1.92205272
74Supernumerary bones of the axial skeleton (HP:0009144)1.92176940
75Insomnia (HP:0100785)1.91040639
76Broad face (HP:0000283)1.87870780
77Thin bony cortex (HP:0002753)1.85407154
78Renovascular hypertension (HP:0100817)1.85272257
79Increased neuronal autofluorescent lipopigment (HP:0002074)1.84633921
80Intellectual disability, severe (HP:0010864)1.84181907
81Prolonged QT interval (HP:0001657)1.83385119
82Retinal dysplasia (HP:0007973)1.82923221
83Overriding aorta (HP:0002623)1.82293556
84Achilles tendon contracture (HP:0001771)1.82150607
85Vasculitis (HP:0002633)1.81974422
86Meningitis (HP:0001287)1.80487744
87Mucopolysacchariduria (HP:0008155)1.80431373
88Urinary glycosaminoglycan excretion (HP:0003541)1.80431373
89Spinal muscular atrophy (HP:0007269)1.80410042
90Attenuation of retinal blood vessels (HP:0007843)1.79840515
91Onion bulb formation (HP:0003383)1.79637536
92Selective tooth agenesis (HP:0001592)1.79501597
93Hypercortisolism (HP:0001578)1.78509986
94Mesangial abnormality (HP:0001966)1.78319204
95Decreased circulating renin level (HP:0003351)1.77860867
96Tented upper lip vermilion (HP:0010804)1.77322989
97Macroglossia (HP:0000158)1.75907439
98Urinary bladder sphincter dysfunction (HP:0002839)1.75377307
99Vertebral fusion (HP:0002948)1.74853479
100Keratoconjunctivitis (HP:0001096)1.74442239
101Persistence of primary teeth (HP:0006335)1.74139556
102Mediastinal lymphadenopathy (HP:0100721)1.74015708
103Keratoconjunctivitis sicca (HP:0001097)1.73816739
104Neoplasm of striated muscle (HP:0009728)1.73809622
105Recurrent abscess formation (HP:0002722)1.73041494
106Mitral valve prolapse (HP:0001634)1.72900070
107Panhypogammaglobulinemia (HP:0003139)1.72839266
108Gastrointestinal inflammation (HP:0004386)1.72515276
109Cheilitis (HP:0100825)1.72366950
110Impaired smooth pursuit (HP:0007772)1.72353859
111Easy fatigability (HP:0003388)1.71592707
112Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70584707
113Short 4th metacarpal (HP:0010044)1.70584707
114Vertebral hypoplasia (HP:0008417)1.70576347
115Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.70576347
116Aplasia/hypoplasia of the humerus (HP:0006507)1.70452430
117Preauricular skin tag (HP:0000384)1.70358552
118Agitation (HP:0000713)1.70350239
119Ocular albinism (HP:0001107)1.70330342
120Recurrent skin infections (HP:0001581)1.70306114
121Amyotrophic lateral sclerosis (HP:0007354)1.69874153
122Abnormality of macrophages (HP:0004311)1.69290006
123Chest pain (HP:0100749)1.69218181
124Chronic obstructive pulmonary disease (HP:0006510)1.69103437
125Obstructive lung disease (HP:0006536)1.69103437
126Bowel diverticulosis (HP:0005222)1.68378733
127Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68256178
128Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68256178
129Abnormality of polysaccharide metabolism (HP:0011012)1.68256178
130Somatic mutation (HP:0001428)1.68092716
131Arnold-Chiari malformation (HP:0002308)1.67257969
132Visual hallucinations (HP:0002367)1.67217976
133Large earlobe (HP:0009748)1.66905569
134Flat acetabular roof (HP:0003180)1.66341596
135Increased cerebral lipofuscin (HP:0011813)1.65789719
136Supernumerary ribs (HP:0005815)1.63567244
137Broad phalanges of the hand (HP:0009768)1.63566413
138Broad palm (HP:0001169)1.63484194
139Concave nail (HP:0001598)1.63184832
140Trigonocephaly (HP:0000243)1.62795934
141Disproportionate tall stature (HP:0001519)1.62665357
142Long eyelashes (HP:0000527)1.61847482
143Facial hemangioma (HP:0000329)1.61760097
144Pointed chin (HP:0000307)1.60775800
145Short phalanx of the thumb (HP:0009660)1.60676962
146Aneurysm (HP:0002617)1.59494929
147Neoplasm of the oral cavity (HP:0100649)1.59263093
148Lip pit (HP:0100267)1.58860606
149Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.58307946
150Dysmetric saccades (HP:0000641)1.58180071
151Congenital hip dislocation (HP:0001374)1.58168179
152Hallux valgus (HP:0001822)1.58108157
153Asymmetric septal hypertrophy (HP:0001670)1.58052811
154Focal seizures (HP:0007359)1.57986653
155Absent speech (HP:0001344)1.57946844
156Bicuspid aortic valve (HP:0001647)1.57585856
157Slow saccadic eye movements (HP:0000514)1.57535570
158Febrile seizures (HP:0002373)1.56884580
159Turricephaly (HP:0000262)1.56096127
160Amelogenesis imperfecta (HP:0000705)1.55967922
161Bowing of the arm (HP:0006488)1.55860627
162Bowed forearm bones (HP:0003956)1.55860627
163Split hand (HP:0001171)1.55277313
164Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.54866595
165Short 1st metacarpal (HP:0010034)1.54866595
166Abnormality of the distal phalanges of the toes (HP:0010182)1.54730151
167Deviation of the hallux (HP:0010051)1.54399369
168Inflammation of the large intestine (HP:0002037)1.54069254
169Bony spicule pigmentary retinopathy (HP:0007737)1.53713721
170Dislocated radial head (HP:0003083)1.53713121
171Broad metatarsal (HP:0001783)1.53690798
172Hypoplasia of the pons (HP:0012110)1.53470871
173Decreased electroretinogram (ERG) amplitude (HP:0000654)1.52985746
174Flat cornea (HP:0007720)1.52900038
175Distal lower limb amyotrophy (HP:0008944)1.52635502
176Broad toe (HP:0001837)1.51935022
177Colitis (HP:0002583)1.51794288
178Dysostosis multiplex (HP:0000943)1.51608086
179Abnormality of the musculature of the hand (HP:0001421)1.51256487
180Open mouth (HP:0000194)1.50806150
181Prominent nose (HP:0000448)1.50575094
182Bilateral microphthalmos (HP:0007633)1.50527436
183Shawl scrotum (HP:0000049)1.49327631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.42300195
2ERN13.57237150
3TRIB33.41878977
4MAP3K103.40310035
5ICK3.34066965
6EEF2K3.22798769
7TYRO32.44062261
8MAP4K12.42410739
9RIPK42.13677534
10PKN22.11978290
11MAP3K91.97067227
12PRPF4B1.82340138
13PDGFRA1.81058128
14SIK21.78173564
15GRK61.78125694
16RIPK11.77464653
17BMX1.73179180
18DDR21.69914676
19MATK1.61522280
20ALK1.52535742
21LATS21.50797423
22WNK41.40782791
23MAP2K31.40567916
24HIPK21.39332414
25TAOK11.39028173
26TGFBR21.39021008
27STK101.38787035
28MARK31.37920331
29WNK11.35305231
30MTOR1.32142434
31IRAK41.30189856
32PRKD21.27978126
33FRK1.23888554
34STK111.20823745
35FES1.17230335
36PRKD31.12664023
37CSK1.10019680
38NEK21.07766270
39CDK61.05844557
40SGK2231.05652969
41SGK4941.05652969
42DAPK21.05122755
43PINK11.03022494
44CAMK1D1.00509108
45CDK70.99907032
46SIK30.99617122
47FGFR30.97613053
48MAPK120.97580709
49MAP3K60.96762154
50MAP3K110.96278845
51MARK20.95927895
52CAMK1G0.95063679
53DYRK1B0.94418377
54LRRK20.93225499
55PTK60.93141623
56UHMK10.90886861
57NTRK30.90633941
58MAP3K130.90172194
59CAMK10.90131849
60SGK30.89143099
61ZAP700.88240360
62SMG10.88045847
63TAOK30.88028817
64SGK20.87948114
65CSF1R0.86641680
66MARK10.86575520
67DMPK0.86144340
68PDGFRB0.85917949
69BRD40.85808042
70PIM10.83514491
71MAPK150.83496868
72FGFR40.83300617
73PAK20.81123044
74MAP3K10.79574771
75PAK40.77919075
76MAP3K30.77341197
77MAP3K70.77253183
78RPS6KC10.76796499
79RPS6KL10.76796499
80GRK50.75712565
81PDPK10.75590932
82FGR0.74698700
83RPS6KA60.73212685
84RPS6KB20.72796458
85KIT0.72763664
86TXK0.71870555
87PAK60.70097434
88CDK40.69282438
89PIM20.68731223
90EPHB20.68652883
91HCK0.67939133
92SCYL20.67664627
93BLK0.67399795
94RPS6KA10.67309456
95ADRBK20.66148148
96IRAK10.65809299
97PRKCZ0.64743826
98PTK2B0.64610196
99IKBKB0.63152568
100PTK20.62936211
101PRKCH0.62672229
102CAMK40.61877649
103RPS6KA20.61035299
104RET0.60846827
105MAP2K60.58480606
106TTN0.58437119
107PDK10.57768063
108SIK10.55832827
109DAPK10.55671410
110CAMKK20.54301634
111TYK20.54144083
112IKBKE0.52843931
113PRKCQ0.52738341
114CHUK0.52033560
115PASK0.52010530
116CDC42BPA0.51446501
117MAPK130.49444194
118TLK10.48059425
119DYRK20.48054681
120TESK20.47332342
121AKT20.47074282
122KSR20.46042524
123IRAK20.45935172
124CDK20.45581372
125MAP2K40.45474937
126NTRK10.45233758
127MAPK80.45229763
128ITK0.45120107
129SGK10.44355684
130EGFR0.43829678
131CAMKK10.43039690
132JAK30.42915816
133MAPK10.42872156
134EPHA30.42804018
135YES10.41941119
136GRK10.41765813
137STK380.39899489
138BTK0.39621345
139EPHB10.39201942
140CHEK10.39014034
141MAP2K20.38887425
142FGFR10.37626751
143SYK0.37503103
144NTRK20.37026636
145MAPK70.36469995
146LCK0.35841860
147CDK90.35672342
148GSK3A0.34617159
149TNK20.32933044

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052201.97980597
2Notch signaling pathway_Homo sapiens_hsa043301.92229238
3mTOR signaling pathway_Homo sapiens_hsa041501.90455350
4Acute myeloid leukemia_Homo sapiens_hsa052211.77118605
5B cell receptor signaling pathway_Homo sapiens_hsa046621.72172001
6Glycosaminoglycan degradation_Homo sapiens_hsa005311.59192188
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55969690
8Colorectal cancer_Homo sapiens_hsa052101.53120132
9VEGF signaling pathway_Homo sapiens_hsa043701.51021344
10Morphine addiction_Homo sapiens_hsa050321.51009379
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48860240
12Neurotrophin signaling pathway_Homo sapiens_hsa047221.47349266
13Non-small cell lung cancer_Homo sapiens_hsa052231.38880796
14Thyroid hormone signaling pathway_Homo sapiens_hsa049191.35418147
15Endometrial cancer_Homo sapiens_hsa052131.33579109
16Dorso-ventral axis formation_Homo sapiens_hsa043201.31921044
17Nicotine addiction_Homo sapiens_hsa050331.31856064
18Bladder cancer_Homo sapiens_hsa052191.30939446
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29770074
20Cholinergic synapse_Homo sapiens_hsa047251.29301192
21MicroRNAs in cancer_Homo sapiens_hsa052061.25961204
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24674499
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24073097
24Glioma_Homo sapiens_hsa052141.23043476
25Circadian entrainment_Homo sapiens_hsa047131.22634699
26Adherens junction_Homo sapiens_hsa045201.20585810
27Proteoglycans in cancer_Homo sapiens_hsa052051.18991246
28Osteoclast differentiation_Homo sapiens_hsa043801.18564071
29Pancreatic cancer_Homo sapiens_hsa052121.18452002
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18143492
31Basal cell carcinoma_Homo sapiens_hsa052171.18031637
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17725488
33ErbB signaling pathway_Homo sapiens_hsa040121.17285260
34T cell receptor signaling pathway_Homo sapiens_hsa046601.16251611
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15780755
36Glutamatergic synapse_Homo sapiens_hsa047241.15129447
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13770327
38Hippo signaling pathway_Homo sapiens_hsa043901.13100049
39mRNA surveillance pathway_Homo sapiens_hsa030151.12820243
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.12795288
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10326095
42Oxytocin signaling pathway_Homo sapiens_hsa049211.10222617
43Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10029647
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09088042
45Lysine degradation_Homo sapiens_hsa003101.08580743
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07916844
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06014276
48Thyroid cancer_Homo sapiens_hsa052161.02611752
49Leishmaniasis_Homo sapiens_hsa051401.02260834
50Hepatitis B_Homo sapiens_hsa051611.01664817
51Small cell lung cancer_Homo sapiens_hsa052221.01472878
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00721354
53HTLV-I infection_Homo sapiens_hsa051661.00395453
54Hedgehog signaling pathway_Homo sapiens_hsa043401.00214023
55Renal cell carcinoma_Homo sapiens_hsa052110.99827547
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99232936
57Cocaine addiction_Homo sapiens_hsa050300.98379788
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98353528
59Estrogen signaling pathway_Homo sapiens_hsa049150.97656718
60Shigellosis_Homo sapiens_hsa051310.96679631
61Long-term potentiation_Homo sapiens_hsa047200.95127855
62Wnt signaling pathway_Homo sapiens_hsa043100.94911735
63Insulin secretion_Homo sapiens_hsa049110.94106434
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.93465675
65Prolactin signaling pathway_Homo sapiens_hsa049170.93228121
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93070852
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92701944
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92555555
69GABAergic synapse_Homo sapiens_hsa047270.92124210
70Dopaminergic synapse_Homo sapiens_hsa047280.92079879
71Apoptosis_Homo sapiens_hsa042100.91620572
72Phototransduction_Homo sapiens_hsa047440.91457654
73MAPK signaling pathway_Homo sapiens_hsa040100.90119995
74Gastric acid secretion_Homo sapiens_hsa049710.89484191
75Toxoplasmosis_Homo sapiens_hsa051450.89225325
76HIF-1 signaling pathway_Homo sapiens_hsa040660.88915229
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88308477
78Primary immunodeficiency_Homo sapiens_hsa053400.88155033
79Axon guidance_Homo sapiens_hsa043600.87388662
80Pathways in cancer_Homo sapiens_hsa052000.86926779
81Base excision repair_Homo sapiens_hsa034100.86618886
82Focal adhesion_Homo sapiens_hsa045100.86521189
83Viral myocarditis_Homo sapiens_hsa054160.86460871
84Insulin signaling pathway_Homo sapiens_hsa049100.86413094
85Choline metabolism in cancer_Homo sapiens_hsa052310.86165506
86Ovarian steroidogenesis_Homo sapiens_hsa049130.86099778
87Platelet activation_Homo sapiens_hsa046110.84193254
88cAMP signaling pathway_Homo sapiens_hsa040240.84150847
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.82559949
90Insulin resistance_Homo sapiens_hsa049310.81748759
91Rap1 signaling pathway_Homo sapiens_hsa040150.81690507
92Amphetamine addiction_Homo sapiens_hsa050310.81047021
93Calcium signaling pathway_Homo sapiens_hsa040200.80752587
94Endocytosis_Homo sapiens_hsa041440.80601620
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.79084148
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.78703304
97Long-term depression_Homo sapiens_hsa047300.78385534
98Ras signaling pathway_Homo sapiens_hsa040140.77698235
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77329834
100Malaria_Homo sapiens_hsa051440.77227029
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.76967298
102Synaptic vesicle cycle_Homo sapiens_hsa047210.75663609
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73835643
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73320149
105Prostate cancer_Homo sapiens_hsa052150.73113318
106GnRH signaling pathway_Homo sapiens_hsa049120.72224117
107Olfactory transduction_Homo sapiens_hsa047400.72115650
108Chemokine signaling pathway_Homo sapiens_hsa040620.71931229
109Antigen processing and presentation_Homo sapiens_hsa046120.70954096
110Inositol phosphate metabolism_Homo sapiens_hsa005620.70929834
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.70882714
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.70879768
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70798024
114Salivary secretion_Homo sapiens_hsa049700.70232104
115Type II diabetes mellitus_Homo sapiens_hsa049300.70077422
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.69729816
117RNA transport_Homo sapiens_hsa030130.69517281
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69179236
119Graft-versus-host disease_Homo sapiens_hsa053320.68697432
120Serotonergic synapse_Homo sapiens_hsa047260.68123473
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68073690
122Tuberculosis_Homo sapiens_hsa051520.67814432
123Measles_Homo sapiens_hsa051620.67736345
124FoxO signaling pathway_Homo sapiens_hsa040680.67490895
125Viral carcinogenesis_Homo sapiens_hsa052030.66856206
126TGF-beta signaling pathway_Homo sapiens_hsa043500.66089499
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.64930118
128Salmonella infection_Homo sapiens_hsa051320.64747229
129Herpes simplex infection_Homo sapiens_hsa051680.64519982
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64124397
131Staphylococcus aureus infection_Homo sapiens_hsa051500.62826933
132Regulation of autophagy_Homo sapiens_hsa041400.61334910
133Taste transduction_Homo sapiens_hsa047420.61089171
134TNF signaling pathway_Homo sapiens_hsa046680.60912629
135Amoebiasis_Homo sapiens_hsa051460.60745563
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59468645
137Gap junction_Homo sapiens_hsa045400.59123333
138Spliceosome_Homo sapiens_hsa030400.58500163
139AMPK signaling pathway_Homo sapiens_hsa041520.58300281
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57713688
141Melanogenesis_Homo sapiens_hsa049160.56744550
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55802314
143p53 signaling pathway_Homo sapiens_hsa041150.55770040
144Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55632450
145Prion diseases_Homo sapiens_hsa050200.53361361
146Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52551371

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »