MNX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)9.02940151
2neuron projection extension involved in neuron projection guidance (GO:1902284)8.92253068
3axon extension involved in axon guidance (GO:0048846)8.92253068
4pyrimidine nucleobase catabolic process (GO:0006208)7.68308331
5* motor neuron axon guidance (GO:0008045)7.40654994
6regulation of chemokine-mediated signaling pathway (GO:0070099)7.30207206
7respiratory system process (GO:0003016)6.42357370
8vitamin A metabolic process (GO:0006776)6.05993735
9nucleobase catabolic process (GO:0046113)5.85237961
10Golgi transport vesicle coating (GO:0048200)5.61357598
11COPI coating of Golgi vesicle (GO:0048205)5.61357598
12negative regulation of axon guidance (GO:1902668)5.06185278
13facial nerve structural organization (GO:0021612)4.94592961
14positive regulation of receptor biosynthetic process (GO:0010870)4.63138487
15cell migration in hindbrain (GO:0021535)4.50225687
16cholesterol biosynthetic process (GO:0006695)4.47698923
17regulation of mammary gland epithelial cell proliferation (GO:0033599)4.43865052
18DNA replication checkpoint (GO:0000076)4.34027990
19dendrite morphogenesis (GO:0048813)4.32381399
20lymph vessel development (GO:0001945)4.31278793
21* endocrine pancreas development (GO:0031018)4.23093341
22respiratory tube development (GO:0030323)4.20989360
23axon extension (GO:0048675)4.20576943
24axonal fasciculation (GO:0007413)4.15342233
25negative regulation of erythrocyte differentiation (GO:0045647)4.12581273
26negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.09978384
27retinal ganglion cell axon guidance (GO:0031290)4.09881116
28negative chemotaxis (GO:0050919)4.04119044
29viral mRNA export from host cell nucleus (GO:0046784)4.03303707
30regulation of apoptotic process involved in morphogenesis (GO:1902337)4.01985664
31glandular epithelial cell differentiation (GO:0002067)3.99711274
32sterol biosynthetic process (GO:0016126)3.89881978
33regulation of axon guidance (GO:1902667)3.89320202
34axon cargo transport (GO:0008088)3.89123168
35negative regulation of leukocyte chemotaxis (GO:0002689)3.86293651
36regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.81032470
37DNA replication initiation (GO:0006270)3.79169768
38* neuron fate specification (GO:0048665)3.78947140
39regulation of NFAT protein import into nucleus (GO:0051532)3.74860187
40regulation of glucose import in response to insulin stimulus (GO:2001273)3.74633830
41anatomical structure arrangement (GO:0048532)3.73780336
42embryonic skeletal joint morphogenesis (GO:0060272)3.69198433
43DNA unwinding involved in DNA replication (GO:0006268)3.68132710
44negative regulation of mRNA processing (GO:0050686)3.67444002
45thyroid gland development (GO:0030878)3.67268040
46N-terminal protein amino acid acetylation (GO:0006474)3.65853867
47neurotransmitter secretion (GO:0007269)3.63433637
48protein K6-linked ubiquitination (GO:0085020)3.62262521
49neuron projection extension (GO:1990138)3.61535113
50regulation of mitochondrial translation (GO:0070129)3.58775514
51axon regeneration (GO:0031103)3.58028527
52proline biosynthetic process (GO:0006561)3.53084201
53anterograde axon cargo transport (GO:0008089)3.52290572
54positive regulation of axonogenesis (GO:0050772)3.51920931
55negative regulation of mRNA metabolic process (GO:1903312)3.48556213
56cranial nerve structural organization (GO:0021604)3.44239865
57negative regulation of vascular permeability (GO:0043116)3.43993045
58mating behavior (GO:0007617)3.43874771
59embryonic heart tube development (GO:0035050)3.42940667
60synaptic vesicle maturation (GO:0016188)3.41324279
61outflow tract septum morphogenesis (GO:0003148)3.40209383
62spinal cord association neuron differentiation (GO:0021527)3.37087262
63negative regulation of axon extension (GO:0030517)3.36822068
64mitotic sister chromatid cohesion (GO:0007064)3.36047962
65regulation of translational fidelity (GO:0006450)3.34870669
66regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.33482850
67neuromuscular synaptic transmission (GO:0007274)3.32514808
68tricarboxylic acid metabolic process (GO:0072350)3.30722136
69epithelial cell maturation (GO:0002070)3.30493413
70retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.30450823
71DNA strand elongation involved in DNA replication (GO:0006271)3.24310826
72heterochromatin organization (GO:0070828)3.23608611
73folic acid-containing compound biosynthetic process (GO:0009396)3.22921028
74negative regulation of cell size (GO:0045792)3.21719048
75cochlea development (GO:0090102)3.20829435
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18405953
77negative regulation of microtubule polymerization (GO:0031115)3.18086807
78interkinetic nuclear migration (GO:0022027)3.17971429
79epithelial cell fate commitment (GO:0072148)3.17081845
80chromosome condensation (GO:0030261)3.16314412
81DNA strand elongation (GO:0022616)3.16248285
82protein maturation by protein folding (GO:0022417)3.16067538
83vesicle coating (GO:0006901)3.15586018
84layer formation in cerebral cortex (GO:0021819)3.12491273
85regulation of nuclear cell cycle DNA replication (GO:0033262)3.11596051
86pteridine-containing compound biosynthetic process (GO:0042559)3.09370930
87mitotic chromosome condensation (GO:0007076)3.09128169
88neuron recognition (GO:0008038)3.08899923
89long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.07775981
90mammary gland epithelial cell differentiation (GO:0060644)3.07724772
91nerve growth factor signaling pathway (GO:0038180)3.07578386
92positive regulation of DNA-dependent DNA replication (GO:2000105)3.07316981
93synaptic vesicle docking involved in exocytosis (GO:0016081)3.05578368
94coenzyme A metabolic process (GO:0015936)3.05224070
95neuromuscular process controlling balance (GO:0050885)3.00638939
96cell migration involved in sprouting angiogenesis (GO:0002042)3.00498371
97regulation of chromatin binding (GO:0035561)2.99431065
98negative regulation of RNA splicing (GO:0033119)2.99231527
99cerebellar Purkinje cell layer development (GO:0021680)2.99095924
100negative regulation of axonogenesis (GO:0050771)2.97125994
101maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.96943405
102calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.96289552
103outer ear morphogenesis (GO:0042473)2.95687831
104response to corticosterone (GO:0051412)2.95142882
105chromatin assembly (GO:0031497)2.95061980
106insulin secretion (GO:0030073)2.94985297
107glandular epithelial cell development (GO:0002068)2.93841028
108intermediate filament organization (GO:0045109)2.93707435
109DNA packaging (GO:0006323)2.93544719
110behavioral response to nicotine (GO:0035095)2.93125056
111fatty acid homeostasis (GO:0055089)2.92838672
112spliceosomal tri-snRNP complex assembly (GO:0000244)2.92157347
113regulation of translational termination (GO:0006449)2.92015081
114central nervous system projection neuron axonogenesis (GO:0021952)2.91595751
115isoprenoid biosynthetic process (GO:0008299)2.90496127
116neuronal ion channel clustering (GO:0045161)2.89380720
117regulation of short-term neuronal synaptic plasticity (GO:0048172)2.89226782
118peptidyl-arginine omega-N-methylation (GO:0035247)2.88810268
119regulation of glucocorticoid metabolic process (GO:0031943)2.87809581
120regulation of axon extension (GO:0030516)2.87417288
121response to lipoprotein particle (GO:0055094)2.86469695
122tetrahydrofolate metabolic process (GO:0046653)2.85467409
123protein localization to microtubule (GO:0035372)2.85416384
124axon development (GO:0061564)2.85313597
125positive regulation of insulin secretion (GO:0032024)2.85305669
126transcription from mitochondrial promoter (GO:0006390)2.81885110
127innervation (GO:0060384)2.81092504
128regulation of axonogenesis (GO:0050770)2.80807843
129rRNA transcription (GO:0009303)2.80711797
130regulation of histone H3-K4 methylation (GO:0051569)2.80454922
131membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.79768925
132fatty-acyl-CoA biosynthetic process (GO:0046949)2.77142484
133regulation of fatty acid beta-oxidation (GO:0031998)2.76354081
134nitric oxide mediated signal transduction (GO:0007263)2.75400764
135dendrite development (GO:0016358)2.75327091
136cell communication by electrical coupling (GO:0010644)2.74163645
137endoderm formation (GO:0001706)2.73008218
138cellular response to glucagon stimulus (GO:0071377)2.69717296
139lung-associated mesenchyme development (GO:0060484)2.69390945
140peripheral nervous system neuron development (GO:0048935)2.69346155
141respiratory gaseous exchange (GO:0007585)2.69244804
142positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.67143543
143GDP-mannose metabolic process (GO:0019673)2.65649676
144cellular protein complex localization (GO:0034629)2.64749838
145desmosome organization (GO:0002934)2.63851749
146regulation of type B pancreatic cell apoptotic process (GO:2000674)2.63488827
147exocrine pancreas development (GO:0031017)2.62614097
148telomere maintenance via semi-conservative replication (GO:0032201)2.62322069
149pseudouridine synthesis (GO:0001522)2.62018115
150pituitary gland development (GO:0021983)2.61030604
151proline metabolic process (GO:0006560)2.60507294
152protein retention in ER lumen (GO:0006621)2.59721525
153developmental cell growth (GO:0048588)2.58584980
154protein complex localization (GO:0031503)2.58442698
155establishment of mitochondrion localization (GO:0051654)2.57769552
156pteridine-containing compound metabolic process (GO:0042558)2.57171025
157regulation of DNA-dependent DNA replication (GO:0090329)2.57051774
158cranial nerve morphogenesis (GO:0021602)2.56081588
159regulation of translational elongation (GO:0006448)2.54545140
160pharyngeal system development (GO:0060037)2.54286119
161myelin maintenance (GO:0043217)2.53907203
162DNA synthesis involved in DNA repair (GO:0000731)2.53265426
163folic acid-containing compound metabolic process (GO:0006760)2.51374565
164positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.50950549
165positive regulation of mitotic sister chromatid separation (GO:1901970)2.50950549
166positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.50950549
167folic acid metabolic process (GO:0046655)2.49993571
168positive regulation of glycolytic process (GO:0045821)2.48457588
169mitochondrial DNA metabolic process (GO:0032042)2.47215247
170ribosomal small subunit biogenesis (GO:0042274)2.47056711
171L-alpha-amino acid transmembrane transport (GO:1902475)2.45826046
172mitochondrial RNA metabolic process (GO:0000959)2.42760289
173protein localization to chromosome, centromeric region (GO:0071459)2.42660599
174negative regulation of glycogen metabolic process (GO:0070874)2.42039781
175positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.41216061
176apoptotic process involved in morphogenesis (GO:0060561)2.40660183
177embryonic skeletal system morphogenesis (GO:0048704)2.38237128
178maternal placenta development (GO:0001893)2.37643715
179mitotic sister chromatid segregation (GO:0000070)2.37532482
180regulation of cardioblast proliferation (GO:0003264)2.36536103
181regulation of secondary heart field cardioblast proliferation (GO:0003266)2.36536103
182RNA localization (GO:0006403)2.36108873
183mitotic G1 DNA damage checkpoint (GO:0031571)2.35058026
184G1 DNA damage checkpoint (GO:0044783)2.34960735
185positive regulation of macroautophagy (GO:0016239)2.33316449
186positive regulation of DNA-templated transcription, initiation (GO:2000144)2.31883617
187positive regulation of gluconeogenesis (GO:0045722)2.31010967
188nuclear pore organization (GO:0006999)2.30035745
189type B pancreatic cell development (GO:0003323)2.29933239
190regulation of mesenchymal cell apoptotic process (GO:2001053)2.29040025
191sister chromatid cohesion (GO:0007062)2.28841155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.44238896
2E2F7_22180533_ChIP-Seq_HELA_Human5.83700084
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.96037928
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.59091071
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.24403528
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.20839024
7IKZF1_21737484_ChIP-ChIP_HCT116_Human3.17088523
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.89159284
9* EZH2_27294783_Chip-Seq_ESCs_Mouse2.76438183
10* EZH2_27304074_Chip-Seq_ESCs_Mouse2.76009958
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.73266266
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.72035879
13* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71687766
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67278575
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.59379449
16* OLIG2_26023283_ChIP-Seq_AINV15_Mouse2.56134442
17CDX2_20551321_ChIP-Seq_CACO-2_Human2.49318488
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46379193
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46379193
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.45412892
21MYC_22102868_ChIP-Seq_BL_Human2.38438436
22ESR1_15608294_ChIP-ChIP_MCF-7_Human2.36829862
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36742985
24* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.35903417
25XRN2_22483619_ChIP-Seq_HELA_Human2.33630737
26REST_21632747_ChIP-Seq_MESCs_Mouse2.26216024
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24450449
28ERG_21242973_ChIP-ChIP_JURKAT_Human2.19473972
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.19454996
30TP63_19390658_ChIP-ChIP_HaCaT_Human2.18915752
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18375164
32KDM5A_27292631_Chip-Seq_BREAST_Human2.18309395
33DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.17547574
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15424439
35ZNF263_19887448_ChIP-Seq_K562_Human2.14321078
36ZNF274_21170338_ChIP-Seq_K562_Hela2.14229552
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.03801666
38* RACK7_27058665_Chip-Seq_MCF-7_Human2.02202103
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.99388864
40* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.98370042
41* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95941774
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.91199929
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.89937761
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88474646
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87951759
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87719082
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.84932869
48* RING1B_27294783_Chip-Seq_ESCs_Mouse1.84580871
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83606827
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.83293606
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82205619
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.81754527
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81645114
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81578229
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80701624
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.80526838
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.78450041
58* TTF2_22483619_ChIP-Seq_HELA_Human1.77977274
59* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76984257
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75830164
61* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75648100
62DCP1A_22483619_ChIP-Seq_HELA_Human1.74863699
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71851983
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70624091
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70422567
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69930790
67* RNF2_27304074_Chip-Seq_ESCs_Mouse1.69287464
68VDR_21846776_ChIP-Seq_THP-1_Human1.68153408
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.59285207
70GABP_19822575_ChIP-Seq_HepG2_Human1.58622697
71PKCTHETA_26484144_Chip-Seq_BREAST_Human1.58339155
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.55122837
73P68_20966046_ChIP-Seq_HELA_Human1.54838326
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54569626
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.54467432
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53989791
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53255819
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.51594898
79IGF1R_20145208_ChIP-Seq_DFB_Human1.50073604
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.49800058
81* RING1B_27294783_Chip-Seq_NPCs_Mouse1.48524861
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45893391
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45839294
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.43946863
85TRIM28_21343339_ChIP-Seq_HEK293_Human1.43341426
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.42537802
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42197779
88MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40393348
89CLOCK_20551151_ChIP-Seq_293T_Human1.39783810
90GBX2_23144817_ChIP-Seq_PC3_Human1.39441400
91CHD1_26751641_Chip-Seq_LNCaP_Human1.37909609
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37571263
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.37383909
94E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34767750
95NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32532979
96TFEB_21752829_ChIP-Seq_HELA_Human1.29999780
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29311255
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29094109
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28328176
100CIITA_25753668_ChIP-Seq_RAJI_Human1.28178118
101* KDM2B_26808549_Chip-Seq_K562_Human1.27556209
102* CBX2_27304074_Chip-Seq_ESCs_Mouse1.26891952
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26829156
104* SOX3_22085726_ChIP-Seq_NPCs_Mouse1.26532516
105NOTCH1_21737748_ChIP-Seq_TLL_Human1.25609034
106AR_21909140_ChIP-Seq_LNCAP_Human1.25231395
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25101897
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23104684
109ATF3_27146783_Chip-Seq_COLON_Human1.20878477
110ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20684305
111FOXP1_21924763_ChIP-Seq_HESCs_Human1.20393441
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19270784
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18542898
114POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18511685
115RUNX1_27514584_Chip-Seq_MCF-7_Human1.17072759
116* ELF1_20517297_ChIP-Seq_JURKAT_Human1.15398891
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15262968
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14951008
119YY1_21170310_ChIP-Seq_MESCs_Mouse1.14738068
120E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14444571
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13625228
122DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12477522
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12307125
124GATA6_25053715_ChIP-Seq_YYC3_Human1.12170733
125NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11860916
126CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11616806
127STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08320513
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07386673
129KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07203578
130KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07203578
131KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07203578
132KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06012517
133KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05662765
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05612099
135KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05144333
136CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04617868
137CTCF_27219007_Chip-Seq_Bcells_Human1.04525315
138CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04444576
139KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03834214
140CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03783941
141SMC4_20622854_ChIP-Seq_HELA_Human1.03775544
142CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03323930
143PHF8_20622854_ChIP-Seq_HELA_Human1.03207677
144CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02637470
145ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02062425
146* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01438619
147CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00981906
148MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00480193
149ELK3_25401928_ChIP-Seq_HUVEC_Human1.00229160
150* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99752324
151TP63_17297297_ChIP-ChIP_HaCaT_Human0.99222269
152RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99123573
153* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98314880
154KDM2B_26808549_Chip-Seq_DND41_Human0.98224669
155DROSHA_22980978_ChIP-Seq_HELA_Human0.97595205
156WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96932607
157TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95810971
158CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95358090
159ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95282070
160CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94263686
161CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93619910
162ISL1_27105846_Chip-Seq_CPCs_Mouse0.91199172
163PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89925027
164LXR_22292898_ChIP-Seq_THP-1_Human0.89578098
165* CREB1_26743006_Chip-Seq_LNCaP_Human0.89156893
166SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88946416
167REST_19997604_ChIP-ChIP_NEURONS_Mouse0.87539693
168YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85440325
169KLF4_19829295_ChIP-Seq_ESCs_Human0.84684370
170OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79705129
171ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.77874480
172SOX2_21211035_ChIP-Seq_LN229_Gbm0.77543800
173WT1_19549856_ChIP-ChIP_CCG9911_Human0.76394413
174TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75128460
175MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.74485678
176* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.74104867
177PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.72846694
178TOP2B_26459242_ChIP-Seq_MCF-7_Human0.72692332
179* RNF2_27304074_Chip-Seq_NSC_Mouse0.71763445
180AR_19668381_ChIP-Seq_PC3_Human0.71460375

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.88650740
2MP0005423_abnormal_somatic_nervous3.86491721
3MP0003283_abnormal_digestive_organ3.55317477
4MP0010234_abnormal_vibrissa_follicle3.54379535
5MP0004270_analgesia3.53256441
6MP0002163_abnormal_gland_morphology3.27854299
7MP0004142_abnormal_muscle_tone3.23370792
8MP0000678_abnormal_parathyroid_gland3.04130260
9MP0004859_abnormal_synaptic_plasticity3.03195072
10MP0001346_abnormal_lacrimal_gland2.97320251
11MP0005623_abnormal_meninges_morphology2.92317243
12* MP0002184_abnormal_innervation2.81457911
13* MP0000955_abnormal_spinal_cord2.78069979
14MP0002909_abnormal_adrenal_gland2.77415388
15MP0003693_abnormal_embryo_hatching2.68551077
16MP0003111_abnormal_nucleus_morphology2.57862923
17MP0008057_abnormal_DNA_replication2.45317942
18MP0005379_endocrine/exocrine_gland_phen2.44698004
19MP0010094_abnormal_chromosome_stability2.36694822
20MP0001177_atelectasis2.34443213
21MP0002160_abnormal_reproductive_system2.22379406
22MP0000003_abnormal_adipose_tissue2.14428339
23* MP0002693_abnormal_pancreas_physiology2.13101851
24MP0000534_abnormal_ureter_morphology2.05698290
25* MP0001944_abnormal_pancreas_morphology2.05582986
26MP0002139_abnormal_hepatobiliary_system2.00519948
27MP0005645_abnormal_hypothalamus_physiol1.95996143
28MP0003635_abnormal_synaptic_transmissio1.91842945
29MP0010386_abnormal_urinary_bladder1.90795628
30MP0005187_abnormal_penis_morphology1.90647894
31MP0004782_abnormal_surfactant_physiolog1.90432745
32MP0004043_abnormal_pH_regulation1.89051139
33MP0000778_abnormal_nervous_system1.86308244
34MP0009780_abnormal_chondrocyte_physiolo1.82821732
35MP0002234_abnormal_pharynx_morphology1.81279851
36MP0003077_abnormal_cell_cycle1.78295127
37MP0005367_renal/urinary_system_phenotyp1.74550046
38MP0000516_abnormal_urinary_system1.74550046
39MP0004811_abnormal_neuron_physiology1.69572162
40MP0002269_muscular_atrophy1.69034377
41MP0002734_abnormal_mechanical_nocicepti1.68400582
42MP0004957_abnormal_blastocyst_morpholog1.67746707
43MP0000631_abnormal_neuroendocrine_gland1.67454567
44MP0002332_abnormal_exercise_endurance1.61755639
45MP0003329_amyloid_beta_deposits1.60740525
46MP0004185_abnormal_adipocyte_glucose1.60395241
47MP0004858_abnormal_nervous_system1.60380754
48MP0002249_abnormal_larynx_morphology1.60263651
49MP0002063_abnormal_learning/memory/cond1.53806719
50MP0010307_abnormal_tumor_latency1.53227891
51MP0002877_abnormal_melanocyte_morpholog1.52595560
52* MP0002882_abnormal_neuron_morphology1.50912866
53MP0002282_abnormal_trachea_morphology1.50817058
54MP0000462_abnormal_digestive_system1.50564743
55MP0005220_abnormal_exocrine_pancreas1.50211431
56MP0003942_abnormal_urinary_system1.48646464
57MP0002751_abnormal_autonomic_nervous1.46840699
58MP0003787_abnormal_imprinting1.44844438
59MP0000537_abnormal_urethra_morphology1.43904766
60MP0005451_abnormal_body_composition1.43864894
61MP0000467_abnormal_esophagus_morphology1.39447382
62MP0006276_abnormal_autonomic_nervous1.39342671
63MP0003122_maternal_imprinting1.38216246
64MP0001188_hyperpigmentation1.36646123
65MP0002557_abnormal_social/conspecific_i1.35955693
66MP0005646_abnormal_pituitary_gland1.35376943
67MP0008058_abnormal_DNA_repair1.33194190
68MP0005253_abnormal_eye_physiology1.31550026
69MP0009046_muscle_twitch1.31408985
70MP0001348_abnormal_lacrimal_gland1.29944041
71MP0001270_distended_abdomen1.29456176
72MP0008932_abnormal_embryonic_tissue1.28164210
73MP0000566_synostosis1.26568102
74MP0001730_embryonic_growth_arrest1.24693449
75* MP0002752_abnormal_somatic_nervous1.24557755
76MP0003890_abnormal_embryonic-extraembry1.23839530
77MP0000350_abnormal_cell_proliferation1.22851240
78MP0002098_abnormal_vibrissa_morphology1.21752537
79MP0002638_abnormal_pupillary_reflex1.20712031
80MP0005375_adipose_tissue_phenotype1.19790823
81MP0002177_abnormal_outer_ear1.17131566
82MP0005083_abnormal_biliary_tract1.16859840
83MP0002108_abnormal_muscle_morphology1.16152510
84MP0006072_abnormal_retinal_apoptosis1.15814992
85MP0002009_preneoplasia1.15750914
86MP0002078_abnormal_glucose_homeostasis1.15674875
87MP0010352_gastrointestinal_tract_polyps1.15270474
88MP0003786_premature_aging1.14614448
89MP0004264_abnormal_extraembryonic_tissu1.14086880
90MP0001919_abnormal_reproductive_system1.13186845
91MP0002277_abnormal_respiratory_mucosa1.12422664
92MP0003183_abnormal_peptide_metabolism1.12164507
93MP0003119_abnormal_digestive_system1.09970413
94MP0005389_reproductive_system_phenotype1.07244770
95MP0000538_abnormal_urinary_bladder1.06739650
96MP0005670_abnormal_white_adipose1.06635113
97MP0000681_abnormal_thyroid_gland1.06498782
98MP0009672_abnormal_birth_weight1.05886453
99MP0003123_paternal_imprinting1.04961096
100MP0004233_abnormal_muscle_weight1.04535606
101MP0003943_abnormal_hepatobiliary_system1.03738376
102MP0003172_abnormal_lysosome_physiology1.03454725
103* MP0002081_perinatal_lethality1.02116825
104MP0003315_abnormal_perineum_morphology0.99512643
105MP0002733_abnormal_thermal_nociception0.99286513
106MP0000569_abnormal_digit_pigmentation0.97664883
107MP0003868_abnormal_feces_composition0.97412140
108MP0002822_catalepsy0.97372933
109* MP0000759_abnormal_skeletal_muscle0.96558483
110MP0000013_abnormal_adipose_tissue0.96279463
111MP0002210_abnormal_sex_determination0.95597702
112MP0000639_abnormal_adrenal_gland0.95553061
113MP0002064_seizures0.94733302
114MP0001697_abnormal_embryo_size0.92912592
115MP0003121_genomic_imprinting0.92626721
116MP0002114_abnormal_axial_skeleton0.92559969
117MP0003634_abnormal_glial_cell0.92268694
118MP0005380_embryogenesis_phenotype0.91376328
119MP0001672_abnormal_embryogenesis/_devel0.91376328
120MP0002085_abnormal_embryonic_tissue0.90742485
121MP0005501_abnormal_skin_physiology0.90053605
122MP0009745_abnormal_behavioral_response0.89164638
123MP0005248_abnormal_Harderian_gland0.88966342
124MP0002152_abnormal_brain_morphology0.88767653
125MP0002837_dystrophic_cardiac_calcinosis0.88097940
126MP0002932_abnormal_joint_morphology0.88071410
127MP0005076_abnormal_cell_differentiation0.87832698
128MP0003115_abnormal_respiratory_system0.85320349
129MP0003948_abnormal_gas_homeostasis0.85224844
130MP0002970_abnormal_white_adipose0.84982545
131MP0003984_embryonic_growth_retardation0.84927146
132MP0003195_calcinosis0.83767569
133MP0004145_abnormal_muscle_electrophysio0.82663172
134MP0001299_abnormal_eye_distance/0.82659936
135MP0001145_abnormal_male_reproductive0.82637378
136MP0001929_abnormal_gametogenesis0.82231681
137MP0001529_abnormal_vocalization0.81906877
138* MP0003861_abnormal_nervous_system0.81559363
139MP0002928_abnormal_bile_duct0.81548127
140MP0003953_abnormal_hormone_level0.81307231
141MP0001664_abnormal_digestion0.80489065
142MP0002066_abnormal_motor_capabilities/c0.79364645
143MP0002088_abnormal_embryonic_growth/wei0.79045723
144MP0009250_abnormal_appendicular_skeleto0.78568530
145MP0000470_abnormal_stomach_morphology0.78018757
146MP0002080_prenatal_lethality0.77978968
147MP0004019_abnormal_vitamin_homeostasis0.77960511
148MP0002697_abnormal_eye_size0.77924194
149MP0005386_behavior/neurological_phenoty0.77335715
150MP0004924_abnormal_behavior0.77335715
151MP0008961_abnormal_basal_metabolism0.77322867
152MP0008007_abnormal_cellular_replicative0.77133850
153MP0005666_abnormal_adipose_tissue0.75977702
154MP0000733_abnormal_muscle_development0.75840948
155MP0003252_abnormal_bile_duct0.75429933
156MP0003937_abnormal_limbs/digits/tail_de0.75391497
157MP0003698_abnormal_male_reproductive0.75254584
158MP0000049_abnormal_middle_ear0.75169881
159MP0001943_abnormal_respiration0.74756308
160MP0009703_decreased_birth_body0.73639169
161MP0000313_abnormal_cell_death0.73579150
162* MP0000477_abnormal_intestine_morphology0.72814067
163MP0002084_abnormal_developmental_patter0.72624742
164MP0009053_abnormal_anal_canal0.72228073
165MP0001727_abnormal_embryo_implantation0.70345699
166MP0005409_darkened_coat_color0.70336502

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)5.75635856
2Septo-optic dysplasia (HP:0100842)5.62013651
3Abnormal pancreas size (HP:0012094)4.76185940
4Double outlet right ventricle (HP:0001719)4.74841169
5Congenital malformation of the right heart (HP:0011723)4.74841169
6Segmental peripheral demyelination/remyelination (HP:0003481)4.42292485
7Hyperinsulinemic hypoglycemia (HP:0000825)4.23078666
8Unilateral renal agenesis (HP:0000122)4.12400813
9Hyperthyroidism (HP:0000836)3.95577724
10Pheochromocytoma (HP:0002666)3.89061439
11Hypoglycemic seizures (HP:0002173)3.65485870
12Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.54588320
13* Septate vagina (HP:0001153)3.51090480
14Abnormality of the corticospinal tract (HP:0002492)3.44399844
15Agitation (HP:0000713)3.44026048
16Transposition of the great arteries (HP:0001669)3.37345733
17Abnormal connection of the cardiac segments (HP:0011545)3.37345733
18Abnormal ventriculo-arterial connection (HP:0011563)3.37345733
19Truncus arteriosus (HP:0001660)3.33379483
20Poor suck (HP:0002033)3.33322060
21Ankle clonus (HP:0011448)3.33166521
22Abnormality of the pancreatic islet cells (HP:0006476)3.28640389
23Abnormality of endocrine pancreas physiology (HP:0012093)3.28640389
24Insidious onset (HP:0003587)3.27968758
25Termporal pattern (HP:0011008)3.27968758
26Symptomatic seizures (HP:0011145)3.27749984
27Absent septum pellucidum (HP:0001331)3.26769459
28Neuroendocrine neoplasm (HP:0100634)3.19085863
29Ketoacidosis (HP:0001993)3.15202078
30Hypoglycemic coma (HP:0001325)3.10205587
31Tetany (HP:0001281)3.08432559
32Abnormality of the fetal cardiovascular system (HP:0010948)3.05520113
33Abnormal umbilical cord blood vessels (HP:0011403)3.05520113
34Single umbilical artery (HP:0001195)3.05520113
35Abnormality of the aortic arch (HP:0012303)3.05038693
36Insulin-resistant diabetes mellitus (HP:0000831)3.03536770
37Hammertoe (HP:0001765)3.03105037
38Large for gestational age (HP:0001520)3.02818481
39Calcaneovalgus deformity (HP:0001848)3.01441909
40Abnormality of the musculature of the hand (HP:0001421)2.95113535
41Urinary urgency (HP:0000012)2.89214409
42Abnormality of the septum pellucidum (HP:0007375)2.87460875
43Progressive muscle weakness (HP:0003323)2.85734143
44Stridor (HP:0010307)2.82525060
45Abnormality of the phalanges of the hallux (HP:0010057)2.81334078
46Back pain (HP:0003418)2.76489894
47Pancreatic islet-cell hyperplasia (HP:0004510)2.75363659
48Supranuclear gaze palsy (HP:0000605)2.74975632
49Broad distal phalanx of finger (HP:0009836)2.74802347
50Aplasia/Hypoplasia of the brainstem (HP:0007362)2.74542783
51Hypoplasia of the brainstem (HP:0002365)2.74542783
52Birth length less than 3rd percentile (HP:0003561)2.74060327
53Impaired vibration sensation in the lower limbs (HP:0002166)2.71644808
54Growth hormone deficiency (HP:0000824)2.69113462
55Spastic gait (HP:0002064)2.68798128
56Hyperglycemia (HP:0003074)2.68534855
57Cutaneous melanoma (HP:0012056)2.63711873
58Shoulder girdle muscle weakness (HP:0003547)2.60248122
59Deformed tarsal bones (HP:0008119)2.59650319
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.56662023
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.56662023
62Decreased motor nerve conduction velocity (HP:0003431)2.56613179
63Generalized hypotonia (HP:0001290)2.55327444
64Neoplasm of the adrenal gland (HP:0100631)2.53656073
65Hypokinesia (HP:0002375)2.51976940
66Myokymia (HP:0002411)2.51093118
67Pachygyria (HP:0001302)2.50697164
68Hypsarrhythmia (HP:0002521)2.49398133
69Hyperparathyroidism (HP:0000843)2.48542203
70Lymphangioma (HP:0100764)2.47103904
71EEG with generalized epileptiform discharges (HP:0011198)2.44964267
72Adducted thumb (HP:0001181)2.43902209
73Turricephaly (HP:0000262)2.43672414
74Optic nerve hypoplasia (HP:0000609)2.41013370
75Abnormality of the parathyroid morphology (HP:0011766)2.37832372
76Abnormality of the calcaneus (HP:0008364)2.34831511
77Epileptiform EEG discharges (HP:0011182)2.34286831
78Cerebral inclusion bodies (HP:0100314)2.34097719
79Hepatoblastoma (HP:0002884)2.33050787
80Ventricular fibrillation (HP:0001663)2.31585952
81Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30776953
82Abnormality of chromosome segregation (HP:0002916)2.30663992
83Abnormality of magnesium homeostasis (HP:0004921)2.30655689
84Chromsome breakage (HP:0040012)2.28742680
85Abnormality of the lower motor neuron (HP:0002366)2.28390782
86Enlarged penis (HP:0000040)2.27418091
87Heterotopia (HP:0002282)2.26863088
88Neoplasm of the adrenal cortex (HP:0100641)2.26747749
89Insulin resistance (HP:0000855)2.26553280
90Insomnia (HP:0100785)2.25128199
91Testicular neoplasm (HP:0010788)2.23285689
92Lower limb muscle weakness (HP:0007340)2.22042715
93Restlessness (HP:0000711)2.20869615
94Hypomagnesemia (HP:0002917)2.20814733
95Hyperphosphatemia (HP:0002905)2.18753877
96Diminished motivation (HP:0000745)2.16561297
97Delayed gross motor development (HP:0002194)2.16403509
98Apathy (HP:0000741)2.15098246
99Neoplasm of the peripheral nervous system (HP:0100007)2.14577597
100Ulnar bowing (HP:0003031)2.14296461
101Abnormality of the umbilical cord (HP:0010881)2.14032650
102Late onset (HP:0003584)2.12799843
103Hand muscle atrophy (HP:0009130)2.11801976
104Distal sensory impairment (HP:0002936)2.11685925
105Anteriorly placed anus (HP:0001545)2.11348025
106Atrophy/Degeneration involving motor neurons (HP:0007373)2.09769348
107Microretrognathia (HP:0000308)2.09483899
108Onion bulb formation (HP:0003383)2.07900416
109Villous atrophy (HP:0011473)2.07641802
110Abnormality of small intestinal villus morphology (HP:0011472)2.07641802
111Squamous cell carcinoma (HP:0002860)2.06807976
112Neurofibrillary tangles (HP:0002185)2.06703528
113* Bicornuate uterus (HP:0000813)2.06344547
114Prominent metopic ridge (HP:0005487)2.05556218
115Macroorchidism (HP:0000053)2.05430285
116Abnormality of the foot musculature (HP:0001436)2.05259347
117Abnormality of the distal phalanges of the toes (HP:0010182)2.04060861
118Abnormality of calcium-phosphate metabolism (HP:0100530)2.03629093
119Clonus (HP:0002169)2.03170233
120Cortical dysplasia (HP:0002539)2.02764433
121Amyotrophic lateral sclerosis (HP:0007354)2.02535682
122Homocystinuria (HP:0002156)2.02078450
123Abnormality of homocysteine metabolism (HP:0010919)2.02078450
124Foot dorsiflexor weakness (HP:0009027)2.01697194
125Urethral obstruction (HP:0000796)2.01369485
126Steppage gait (HP:0003376)2.01053603
127Asymmetry of the thorax (HP:0001555)2.00211698
128Rectal prolapse (HP:0002035)1.97916440
129Wide cranial sutures (HP:0010537)1.97800129
130Hypercalciuria (HP:0002150)1.95121196
131Abnormality of the anterior horn cell (HP:0006802)1.93730625
132Degeneration of anterior horn cells (HP:0002398)1.93730625
133Polymicrogyria (HP:0002126)1.93688310
134Ketosis (HP:0001946)1.92530279
135Morphological abnormality of the pyramidal tract (HP:0002062)1.92090657
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89780816
137Skin nodule (HP:0200036)1.88664161
138Testicular atrophy (HP:0000029)1.88353751
139Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.86688542
140Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85671406
141Dysmetric saccades (HP:0000641)1.85578894
142Spinal muscular atrophy (HP:0007269)1.85137803
143Hyperacusis (HP:0010780)1.85067068
144Tongue fasciculations (HP:0001308)1.83319706
145Short 4th metacarpal (HP:0010044)1.82459366
146Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82459366
147Depression (HP:0000716)1.82002244
148Lissencephaly (HP:0001339)1.81678745
149Hypercortisolism (HP:0001578)1.81221283
150Visual hallucinations (HP:0002367)1.81210698
151Rimmed vacuoles (HP:0003805)1.80844882
152Abnormal number of incisors (HP:0011064)1.79357155
153Neonatal hypoglycemia (HP:0001998)1.79252054
154Sparse lateral eyebrow (HP:0005338)1.79128571
155Abnormality of the astrocytes (HP:0100707)1.78390566
156Astrocytoma (HP:0009592)1.78390566
157Absent radius (HP:0003974)1.76016875
158Abnormality of the metopic suture (HP:0005556)1.74728113
159Preauricular pit (HP:0004467)1.73305617
160Periauricular skin pits (HP:0100277)1.73305617
161Breast hypoplasia (HP:0003187)1.73244718
162Aplasia/Hypoplasia of the patella (HP:0006498)1.70970912
163Patellar aplasia (HP:0006443)1.69746979
164Aplasia involving forearm bones (HP:0009822)1.68335843
165Absent forearm bone (HP:0003953)1.68335843
166Hypoplastic left heart (HP:0004383)1.67772479
167Atresia of the external auditory canal (HP:0000413)1.66842997
168Menstrual irregularities (HP:0000858)1.65655858
169Truncal obesity (HP:0001956)1.65103787
170Concave nail (HP:0001598)1.64874322
171Short thumb (HP:0009778)1.63670410
172Renal agenesis (HP:0000104)1.63456169
173Trismus (HP:0000211)1.63084437
174Abnormality of the distal phalanx of the thumb (HP:0009617)1.61766415
175Hypoparathyroidism (HP:0000829)1.60589796
176Limb hypertonia (HP:0002509)1.57834315
177Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57395767
178Abnormality of the line of Schwalbe (HP:0008048)1.56055890
179Hypergonadotropic hypogonadism (HP:0000815)1.52636939
180Seborrheic dermatitis (HP:0001051)1.52017041
181Abnormality of the gallbladder (HP:0005264)1.51794235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.73984461
2EEF2K4.96755362
3CDK123.70975884
4LIMK13.55575376
5PASK3.45316964
6IRAK33.38346412
7SMG13.37495534
8NTRK33.22487740
9INSRR3.02562297
10SCYL22.51114003
11SIK12.34725090
12MAP3K42.25513120
13DYRK22.22653406
14NTRK22.09028387
15MAP3K92.07660513
16EPHA22.05216782
17NME21.98862439
18RPS6KB21.97129487
19ERBB31.89894550
20TESK11.88617627
21PAK31.83576268
22MST1R1.79875757
23IRAK21.79308191
24DAPK21.76839174
25MINK11.64926173
26KSR11.62059523
27MAP3K21.60814593
28CDK71.56572699
29HIPK21.53946044
30PRKD31.53443002
31CHEK21.53430152
32NTRK11.51930074
33MAP3K101.49421256
34STK41.43399909
35CAMK1G1.42916381
36PAK61.40655183
37CDC71.36847260
38ICK1.32750502
39FRK1.31847385
40CDK51.30553059
41MAPK111.29439861
42BUB11.28569988
43LMTK21.26367045
44TAOK11.26298409
45MAP2K41.26060207
46PRKCG1.25410209
47TLK11.23582661
48CAMK1D1.21485094
49BCR1.20311777
50CDK81.20121000
51PRKCZ1.19129688
52UHMK11.17647794
53KSR21.17378634
54WNK41.16042933
55CDC42BPA1.13782975
56MTOR1.11321392
57BRAF1.10901475
58MAPKAPK31.09132716
59ILK1.08745176
60EPHA41.05776090
61MAPK151.05081137
62FGFR41.05013792
63WNK31.04562696
64MAPK131.04005486
65TESK21.03507876
66VRK21.03021196
67BRD41.02367528
68ATR1.01401982
69RET1.00887467
70PTK21.00794866
71MAP2K61.00649438
72CHEK10.98607713
73AURKA0.96071663
74TRIB30.94321570
75PDPK10.94022623
76DYRK1B0.89903193
77FGFR20.89738402
78TTK0.89674235
79BRSK10.88297878
80CSNK1G30.88212854
81SIK20.88130961
82MAP2K20.85356977
83MAP2K70.83337100
84PRKCE0.82054434
85MAP3K10.81182847
86CSNK1G20.81136004
87FER0.80348690
88IRAK40.79651307
89PRKCI0.77271687
90PRKAA10.75444327
91CDK40.74353102
92AKT20.74348518
93EIF2AK10.73839330
94PHKG20.72729391
95PHKG10.72729391
96CSNK1A1L0.71668216
97CSNK1E0.71013902
98RPS6KA20.70261317
99ZAK0.69638514
100IRAK10.68993290
101CAMKK10.68892908
102CDK30.68114051
103AKT30.67748353
104PRKAA20.67589060
105ALK0.67267897
106PRKD20.66869720
107SGK2230.66360930
108SGK4940.66360930
109STK390.65864793
110PKN20.65459216
111DYRK30.64930568
112EIF2AK20.64169863
113PNCK0.63894943
114RIPK10.61972791
115FGFR30.61807075
116TAF10.60976963
117MAP3K80.60834078
118ADRBK10.60653377
119DAPK10.60345136
120TAOK30.59770176
121CDK140.59098353
122PRKD10.59043681
123CDK20.58723530
124PTK60.58603023
125CAMK2A0.57826485
126ROCK10.57597656
127MAP3K60.57418724
128VRK10.57351153
129STK240.56073912
130CAMKK20.54980923
131PLK40.54980176
132MARK20.54457003
133AURKB0.54279205
134ROCK20.53791804
135WEE10.53735578
136CSF1R0.52521862
137CHUK0.52367421
138ERN10.52312221
139RPS6KA50.52262145
140CAMK2G0.51775545
141MAPKAPK50.51572042
142PDK10.50811251
143MKNK20.49828417
144PAK20.49709730
145MAPK90.49260612
146PRKACB0.49206536
147ATM0.49108939
148PLK10.48862402
149SRPK10.48777356
150CDK10.48124314
151CDK150.47835759
152ERBB20.47392213
153PRKDC0.46766554
154KDR0.46512839
155CSNK1G10.46187295
156CDK180.45612050
157MELK0.44736244
158PRPF4B0.44210481
159MAP2K10.43792781
160CAMK2B0.43448428
161MAPK140.43317658
162TRPM70.41727676
163GSK3A0.41310689
164EPHB20.40983464
165CDK11A0.40645077
166PRKG20.40616510
167MAP2K30.40205401
168IGF1R0.40083106
169STK30.39049018
170PRKACG0.37905523
171PRKCH0.37422575
172PDGFRA0.37410233
173CSNK2A20.36450730
174STK110.36394225
175PRKCB0.34703763
176RPS6KA30.31160951

Predicted pathways (KEGG)

RankGene SetZ-score
1* Maturity onset diabetes of the young_Homo sapiens_hsa049505.78066279
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.00127311
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.63097358
4Vitamin B6 metabolism_Homo sapiens_hsa007503.34197192
5Steroid biosynthesis_Homo sapiens_hsa001003.17175972
6Sulfur relay system_Homo sapiens_hsa041223.14909558
7DNA replication_Homo sapiens_hsa030303.11446924
8Synaptic vesicle cycle_Homo sapiens_hsa047212.99307564
9Type II diabetes mellitus_Homo sapiens_hsa049302.69493041
10Cholinergic synapse_Homo sapiens_hsa047252.33569438
11Butanoate metabolism_Homo sapiens_hsa006502.33206631
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.27604429
13One carbon pool by folate_Homo sapiens_hsa006702.21523898
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09468952
15Insulin secretion_Homo sapiens_hsa049112.01880592
16Sulfur metabolism_Homo sapiens_hsa009202.01821381
17Base excision repair_Homo sapiens_hsa034101.96499766
18Folate biosynthesis_Homo sapiens_hsa007901.84645127
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81316204
20Homologous recombination_Homo sapiens_hsa034401.80431540
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67527225
22Axon guidance_Homo sapiens_hsa043601.64474790
23Vibrio cholerae infection_Homo sapiens_hsa051101.62823107
24Dopaminergic synapse_Homo sapiens_hsa047281.58243008
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51966875
26Fructose and mannose metabolism_Homo sapiens_hsa000511.49547932
27Cocaine addiction_Homo sapiens_hsa050301.44776993
28Cell cycle_Homo sapiens_hsa041101.42038140
29Fatty acid biosynthesis_Homo sapiens_hsa000611.40538161
30Pyrimidine metabolism_Homo sapiens_hsa002401.38914923
31RNA transport_Homo sapiens_hsa030131.38037281
32Spliceosome_Homo sapiens_hsa030401.34785840
33Mismatch repair_Homo sapiens_hsa034301.33383378
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32675223
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.27425996
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27132294
37Protein export_Homo sapiens_hsa030601.20538186
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.16388810
39Amphetamine addiction_Homo sapiens_hsa050311.15531759
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15298761
41Endometrial cancer_Homo sapiens_hsa052131.12035048
42Arginine biosynthesis_Homo sapiens_hsa002201.10428772
43Prion diseases_Homo sapiens_hsa050201.09521078
44N-Glycan biosynthesis_Homo sapiens_hsa005101.09423718
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09309058
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08428113
47Galactose metabolism_Homo sapiens_hsa000521.08293329
48Arginine and proline metabolism_Homo sapiens_hsa003301.08269816
49Long-term potentiation_Homo sapiens_hsa047201.07406467
50mRNA surveillance pathway_Homo sapiens_hsa030151.07339636
51Non-homologous end-joining_Homo sapiens_hsa034501.05176518
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05039722
53Estrogen signaling pathway_Homo sapiens_hsa049151.02944950
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02578771
55GABAergic synapse_Homo sapiens_hsa047271.01871332
56Fanconi anemia pathway_Homo sapiens_hsa034601.01374015
57Nucleotide excision repair_Homo sapiens_hsa034200.99773179
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98045666
59Gap junction_Homo sapiens_hsa045400.95322661
60RNA polymerase_Homo sapiens_hsa030200.93934251
61Prostate cancer_Homo sapiens_hsa052150.93744589
62Insulin resistance_Homo sapiens_hsa049310.93159581
63Circadian entrainment_Homo sapiens_hsa047130.92962057
64mTOR signaling pathway_Homo sapiens_hsa041500.92569856
65Biosynthesis of amino acids_Homo sapiens_hsa012300.92246715
66Glioma_Homo sapiens_hsa052140.91980823
67Insulin signaling pathway_Homo sapiens_hsa049100.91012708
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88943932
69Prolactin signaling pathway_Homo sapiens_hsa049170.88820753
70Colorectal cancer_Homo sapiens_hsa052100.86493843
71Systemic lupus erythematosus_Homo sapiens_hsa053220.83646186
72Vitamin digestion and absorption_Homo sapiens_hsa049770.83085063
73Basal transcription factors_Homo sapiens_hsa030220.82293968
74Pentose phosphate pathway_Homo sapiens_hsa000300.81543971
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.80884533
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80657790
77Purine metabolism_Homo sapiens_hsa002300.80228993
78Selenocompound metabolism_Homo sapiens_hsa004500.79891526
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78503230
80Taste transduction_Homo sapiens_hsa047420.77667278
81Fat digestion and absorption_Homo sapiens_hsa049750.77584539
82ErbB signaling pathway_Homo sapiens_hsa040120.77182302
83Alcoholism_Homo sapiens_hsa050340.76631945
84Sphingolipid metabolism_Homo sapiens_hsa006000.75904879
85Non-small cell lung cancer_Homo sapiens_hsa052230.74519208
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74266509
87Other glycan degradation_Homo sapiens_hsa005110.73402537
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72686311
89Thyroid cancer_Homo sapiens_hsa052160.71953558
90Type I diabetes mellitus_Homo sapiens_hsa049400.71812000
91Tryptophan metabolism_Homo sapiens_hsa003800.71179401
92Notch signaling pathway_Homo sapiens_hsa043300.70677474
93Chronic myeloid leukemia_Homo sapiens_hsa052200.70473225
94AMPK signaling pathway_Homo sapiens_hsa041520.70224924
95Renal cell carcinoma_Homo sapiens_hsa052110.69599303
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68765413
97Melanoma_Homo sapiens_hsa052180.67970645
98VEGF signaling pathway_Homo sapiens_hsa043700.67460842
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63745969
100Glucagon signaling pathway_Homo sapiens_hsa049220.63701610
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63556229
102Hedgehog signaling pathway_Homo sapiens_hsa043400.59657042
103Inositol phosphate metabolism_Homo sapiens_hsa005620.58962432
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58825667
105p53 signaling pathway_Homo sapiens_hsa041150.58810470
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57580119
107Serotonergic synapse_Homo sapiens_hsa047260.56402290
108Glutamatergic synapse_Homo sapiens_hsa047240.56344390
109Carbon metabolism_Homo sapiens_hsa012000.55472505
110Nitrogen metabolism_Homo sapiens_hsa009100.54372877
111Fatty acid metabolism_Homo sapiens_hsa012120.54317240
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53931328
113ABC transporters_Homo sapiens_hsa020100.53647005
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53421569
115Basal cell carcinoma_Homo sapiens_hsa052170.53279696
116Phagosome_Homo sapiens_hsa041450.52196775
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52142444
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51852913
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51777246
120Morphine addiction_Homo sapiens_hsa050320.51584477
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.50727801
122Oocyte meiosis_Homo sapiens_hsa041140.50607196
123Nicotine addiction_Homo sapiens_hsa050330.50028306
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48057800
125Collecting duct acid secretion_Homo sapiens_hsa049660.48007692
126Viral carcinogenesis_Homo sapiens_hsa052030.47743441
127Pancreatic cancer_Homo sapiens_hsa052120.47593378
128Lysine degradation_Homo sapiens_hsa003100.47580748
129Phenylalanine metabolism_Homo sapiens_hsa003600.47572818
130GnRH signaling pathway_Homo sapiens_hsa049120.46923421
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.46171674
132Ribosome_Homo sapiens_hsa030100.44317343
133Alzheimers disease_Homo sapiens_hsa050100.43269567
134Hippo signaling pathway_Homo sapiens_hsa043900.41743810
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41680594
136Tight junction_Homo sapiens_hsa045300.41228506
137Long-term depression_Homo sapiens_hsa047300.40778738
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39370118
139Metabolic pathways_Homo sapiens_hsa011000.37635974
140Bladder cancer_Homo sapiens_hsa052190.37187649
141MAPK signaling pathway_Homo sapiens_hsa040100.36462149
142FoxO signaling pathway_Homo sapiens_hsa040680.35561096
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.34932410
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33609487
145Circadian rhythm_Homo sapiens_hsa047100.30999424
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30763048
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30371135
148Choline metabolism in cancer_Homo sapiens_hsa052310.30358186
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30089204
150Bile secretion_Homo sapiens_hsa049760.28910384
151Fatty acid elongation_Homo sapiens_hsa000620.28787262
152Parkinsons disease_Homo sapiens_hsa050120.28649761
153Thyroid hormone synthesis_Homo sapiens_hsa049180.26517756
154Cyanoamino acid metabolism_Homo sapiens_hsa004600.26472748
155Pancreatic secretion_Homo sapiens_hsa049720.26274184
156Endocytosis_Homo sapiens_hsa041440.26254559

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