MOAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.36021718
2vocalization behavior (GO:0071625)5.00172455
3membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.98852462
4regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.71685598
5gamma-aminobutyric acid transport (GO:0015812)4.68461138
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.58940808
7regulation of synapse structural plasticity (GO:0051823)4.52640566
8establishment of mitochondrion localization (GO:0051654)4.39576468
9cellular potassium ion homeostasis (GO:0030007)4.36560157
10synaptic vesicle exocytosis (GO:0016079)4.36408394
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.31679476
12ATP synthesis coupled proton transport (GO:0015986)4.28741162
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.28741162
14chaperone-mediated protein transport (GO:0072321)4.19883730
15regulation of glutamate receptor signaling pathway (GO:1900449)4.16766325
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.10603751
17regulation of neurotransmitter levels (GO:0001505)4.06008996
18pyrimidine nucleobase catabolic process (GO:0006208)4.05870328
19regulation of neuronal synaptic plasticity (GO:0048168)4.04252008
20sodium ion export (GO:0071436)4.03662863
21regulation of vesicle fusion (GO:0031338)3.97680320
22energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.96267644
23ATP hydrolysis coupled proton transport (GO:0015991)3.96267644
24protein localization to synapse (GO:0035418)3.91690004
25cerebellar granule cell differentiation (GO:0021707)3.76856996
26locomotory exploration behavior (GO:0035641)3.76505472
27presynaptic membrane assembly (GO:0097105)3.73745464
28dendritic spine morphogenesis (GO:0060997)3.71585350
29response to histamine (GO:0034776)3.68867718
30postsynaptic membrane organization (GO:0001941)3.65961072
31gamma-aminobutyric acid signaling pathway (GO:0007214)3.63967661
32neuronal ion channel clustering (GO:0045161)3.62949655
33cerebellar Purkinje cell differentiation (GO:0021702)3.61328546
34neuron-neuron synaptic transmission (GO:0007270)3.60885616
35regulation of voltage-gated calcium channel activity (GO:1901385)3.60598509
36neuronal action potential propagation (GO:0019227)3.60312067
37cullin deneddylation (GO:0010388)3.58346587
38layer formation in cerebral cortex (GO:0021819)3.56902438
39regulation of synaptic vesicle exocytosis (GO:2000300)3.55883491
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.55369637
41transferrin transport (GO:0033572)3.51629992
42neuron recognition (GO:0008038)3.50974687
43presynaptic membrane organization (GO:0097090)3.50076308
44glutamate secretion (GO:0014047)3.48877199
45exploration behavior (GO:0035640)3.48838372
46negative regulation of microtubule polymerization (GO:0031115)3.48352224
47regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.48112875
48positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.45863707
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.45540499
50neuromuscular synaptic transmission (GO:0007274)3.42797931
51regulation of glutamate secretion (GO:0014048)3.41645137
52regulation of neurotransmitter transport (GO:0051588)3.40136215
53L-amino acid import (GO:0043092)3.39803793
54synaptic vesicle transport (GO:0048489)3.39622118
55establishment of synaptic vesicle localization (GO:0097480)3.39622118
56synaptic vesicle docking involved in exocytosis (GO:0016081)3.39593509
57amino acid import (GO:0043090)3.39195693
58protein localization to cilium (GO:0061512)3.36321282
59nucleobase catabolic process (GO:0046113)3.36033333
60protein deneddylation (GO:0000338)3.35550438
61neurofilament cytoskeleton organization (GO:0060052)3.34851237
62positive regulation of synapse assembly (GO:0051965)3.34463558
63glutamate receptor signaling pathway (GO:0007215)3.32956698
64acidic amino acid transport (GO:0015800)3.30929609
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.30586492
66membrane depolarization during action potential (GO:0086010)3.29569649
67establishment of protein localization to mitochondrial membrane (GO:0090151)3.29423995
68synaptic transmission, dopaminergic (GO:0001963)3.28829988
69regulation of dendritic spine morphogenesis (GO:0061001)3.27592170
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.26191599
71dendritic spine organization (GO:0097061)3.25632793
72mitochondrion transport along microtubule (GO:0047497)3.24687466
73establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.24687466
74cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.23947476
75neurotransmitter secretion (GO:0007269)3.22973232
76regulation of synaptic plasticity (GO:0048167)3.22929924
77long-term memory (GO:0007616)3.22861407
78synapse assembly (GO:0007416)3.22810661
79synaptic transmission (GO:0007268)3.19603140
80ferric iron transport (GO:0015682)3.19559428
81trivalent inorganic cation transport (GO:0072512)3.19559428
82long-term synaptic potentiation (GO:0060291)3.19538813
83synaptic vesicle maturation (GO:0016188)3.18764345
84positive regulation of synapse maturation (GO:0090129)3.17260119
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.16957124
86positive regulation of dendritic spine morphogenesis (GO:0061003)3.16122319
87ionotropic glutamate receptor signaling pathway (GO:0035235)3.13271565
88cell migration in hindbrain (GO:0021535)3.12655816
89glycosphingolipid biosynthetic process (GO:0006688)3.12431635
90membrane depolarization (GO:0051899)3.12383122
91detection of calcium ion (GO:0005513)3.12309101
92regulation of synaptic vesicle transport (GO:1902803)3.11883080
93positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.10393550
94auditory behavior (GO:0031223)3.10337044
95establishment of vesicle localization (GO:0051650)3.08461265
96behavioral response to cocaine (GO:0048148)3.06841801
97positive regulation of dendritic spine development (GO:0060999)3.06800562
98axonal fasciculation (GO:0007413)3.06497540
99synaptic transmission, glutamatergic (GO:0035249)3.03022889
100positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98268093
101positive regulation of neurotransmitter transport (GO:0051590)2.96350048
102adult walking behavior (GO:0007628)2.95687738
103neurotransmitter-gated ion channel clustering (GO:0072578)2.95595667
104G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95282514
105respiratory electron transport chain (GO:0022904)2.95258480
106organelle transport along microtubule (GO:0072384)2.94958829
107mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.94548686
108potassium ion homeostasis (GO:0055075)2.94212145
109protein complex biogenesis (GO:0070271)2.92898432
110regulation of protein kinase A signaling (GO:0010738)2.92813657
111electron transport chain (GO:0022900)2.92007649
112response to dietary excess (GO:0002021)2.91496760
113startle response (GO:0001964)2.91290315
114regulation of synaptic transmission (GO:0050804)2.89263569
115regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.89078622
116regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.89078622
117cellular sodium ion homeostasis (GO:0006883)2.87764247
118behavioral defense response (GO:0002209)2.87038745
119behavioral fear response (GO:0001662)2.87038745
120potassium ion import (GO:0010107)2.86116783
121positive regulation of neurotransmitter secretion (GO:0001956)2.85569959
122regulation of synaptic transmission, glutamatergic (GO:0051966)2.84652700
123fear response (GO:0042596)2.82079555
124response to cocaine (GO:0042220)2.80789533
125urinary tract smooth muscle contraction (GO:0014848)2.78659582
126transmission of nerve impulse (GO:0019226)2.78475424
127calcium ion-dependent exocytosis (GO:0017156)2.76566656
128opioid receptor signaling pathway (GO:0038003)2.75380737
129cilium or flagellum-dependent cell motility (GO:0001539)2.73798905
130GTP biosynthetic process (GO:0006183)2.72375622
131positive regulation of cellular response to oxidative stress (GO:1900409)2.71968114
132positive regulation of response to oxidative stress (GO:1902884)2.71968114
133neurotransmitter transport (GO:0006836)2.71614298
134hydrogen ion transmembrane transport (GO:1902600)2.71065792
135cellular response to ammonium ion (GO:0071242)2.70543754
136regulation of excitatory postsynaptic membrane potential (GO:0060079)2.70460676
137regulation of cilium movement (GO:0003352)2.70302783
138regulation of synapse assembly (GO:0051963)2.70293551
139proline transport (GO:0015824)2.70188829
140mitochondrial respiratory chain complex assembly (GO:0033108)2.69588269
141positive regulation of membrane potential (GO:0045838)2.68823370
142negative regulation of amine transport (GO:0051953)2.67553249
143regulation of postsynaptic membrane potential (GO:0060078)2.66316805
144regulation of long-term neuronal synaptic plasticity (GO:0048169)2.65708702
145protein neddylation (GO:0045116)2.65402840
146striatum development (GO:0021756)2.63634731
147synaptic vesicle endocytosis (GO:0048488)2.63532993
148mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.63150779
149mitochondrial respiratory chain complex I assembly (GO:0032981)2.63150779
150NADH dehydrogenase complex assembly (GO:0010257)2.63150779
151regulation of neurotransmitter secretion (GO:0046928)2.62401206
152regulation of synapse maturation (GO:0090128)2.61620769
153positive regulation of mitochondrial fission (GO:0090141)2.60848133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.13013771
2GBX2_23144817_ChIP-Seq_PC3_Human3.84384620
3TAF15_26573619_Chip-Seq_HEK293_Human3.19299664
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.64085980
5REST_21632747_ChIP-Seq_MESCs_Mouse2.61206109
6DROSHA_22980978_ChIP-Seq_HELA_Human2.50446231
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.40288607
8CTBP1_25329375_ChIP-Seq_LNCAP_Human2.24447895
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21633126
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20280291
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14770533
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.12967433
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.10736851
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.10277109
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09396508
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.07925805
17FUS_26573619_Chip-Seq_HEK293_Human2.05386413
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02278549
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95932537
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.94268384
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.94208521
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88094080
23RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.84922579
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83856807
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83141670
26RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.81121281
27* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79747899
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76879446
29* ZNF274_21170338_ChIP-Seq_K562_Hela1.75350025
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74053619
31P300_19829295_ChIP-Seq_ESCs_Human1.73008865
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72598363
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70279903
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.69558225
35RNF2_27304074_Chip-Seq_NSC_Mouse1.69470930
36VDR_22108803_ChIP-Seq_LS180_Human1.68975837
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66554013
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66425989
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65862658
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.62351237
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62321934
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56730186
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56041414
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54054562
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53545110
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53545110
47SMAD4_21799915_ChIP-Seq_A2780_Human1.51456441
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.48339843
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47497597
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.46566779
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45378596
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44282441
53IGF1R_20145208_ChIP-Seq_DFB_Human1.42517668
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42422443
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42280892
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41702831
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40948839
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39162178
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.37959627
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37225742
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.36504013
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35261922
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.34512828
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33872851
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.33063135
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30252815
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.30008114
68* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29388743
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24494571
70AR_21572438_ChIP-Seq_LNCaP_Human1.22277966
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22170010
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21686615
73ER_23166858_ChIP-Seq_MCF-7_Human1.20580933
74EWS_26573619_Chip-Seq_HEK293_Human1.19367723
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18352831
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16955035
77CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.16561485
78SOX9_26525672_Chip-Seq_HEART_Mouse1.16200641
79* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15450360
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.13477317
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13363068
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13263970
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13230277
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12670675
85JUN_21703547_ChIP-Seq_K562_Human1.12373669
86* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11663914
87TET1_21490601_ChIP-Seq_MESCs_Mouse1.11655314
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10299053
89AR_19668381_ChIP-Seq_PC3_Human1.09697835
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09269369
91REST_19997604_ChIP-ChIP_NEURONS_Mouse1.08288992
92ETS1_20019798_ChIP-Seq_JURKAT_Human1.08050899
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.08000068
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.07625888
95* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07254850
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07093764
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.07040334
98GATA1_26923725_Chip-Seq_HPCs_Mouse1.04898053
99AR_25329375_ChIP-Seq_VCAP_Human1.03781120
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01732285
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00495321
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00428057
103SOX2_21211035_ChIP-Seq_LN229_Gbm0.99727553
104NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99723463
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99648179
106KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96990431
107P53_22387025_ChIP-Seq_ESCs_Mouse0.96725161
108P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95867986
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95243103
110PRDM14_20953172_ChIP-Seq_ESCs_Human0.94978460
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94802297
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94758397
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94733297
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94605442
115CBP_20019798_ChIP-Seq_JUKART_Human0.94605442
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94421574
117PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94044205
118* TCF4_23295773_ChIP-Seq_U87_Human0.92612154
119KDM2B_26808549_Chip-Seq_K562_Human0.92350546
120RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91187867
121* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89274401
122CTCF_27219007_Chip-Seq_Bcells_Human0.87011883
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86587771
124SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83956316
125WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82866669
126EGR1_19032775_ChIP-ChIP_M12_Human0.82342571
127FLI1_21867929_ChIP-Seq_TH2_Mouse0.80648151
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80284018
129SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79240059
130STAT3_23295773_ChIP-Seq_U87_Human0.79133475
131OCT4_19829295_ChIP-Seq_ESCs_Human0.78724868
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78333969
133TAL1_26923725_Chip-Seq_HPCs_Mouse0.75038050
134LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73658551
135* RING1B_27294783_Chip-Seq_NPCs_Mouse0.72605897
136RUNX2_22187159_ChIP-Seq_PCA_Human0.67559984
137VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.67086020

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.99123016
2MP0004859_abnormal_synaptic_plasticity3.59510711
3MP0001529_abnormal_vocalization3.40964953
4MP0003635_abnormal_synaptic_transmissio3.32062837
5MP0006276_abnormal_autonomic_nervous3.06229429
6MP0009046_muscle_twitch2.99038509
7MP0009745_abnormal_behavioral_response2.91797921
8MP0002063_abnormal_learning/memory/cond2.82171191
9MP0003122_maternal_imprinting2.81964040
10MP0001968_abnormal_touch/_nociception2.79426865
11MP0002064_seizures2.75147634
12MP0002572_abnormal_emotion/affect_behav2.66033976
13MP0002736_abnormal_nociception_after2.59878558
14MP0005423_abnormal_somatic_nervous2.54884947
15MP0004270_analgesia2.50976851
16MP0002735_abnormal_chemical_nociception2.46968431
17MP0001984_abnormal_olfaction2.44011804
18MP0002734_abnormal_mechanical_nocicepti2.41811624
19MP0002272_abnormal_nervous_system2.31139220
20MP0008877_abnormal_DNA_methylation2.19673896
21MP0001440_abnormal_grooming_behavior2.07880356
22MP0001486_abnormal_startle_reflex2.01744139
23MP0001188_hyperpigmentation2.01195502
24MP0003787_abnormal_imprinting1.95562428
25MP0002184_abnormal_innervation1.86860215
26MP0002067_abnormal_sensory_capabilities1.86625051
27MP0002733_abnormal_thermal_nociception1.86054893
28MP0001501_abnormal_sleep_pattern1.85186000
29MP0003121_genomic_imprinting1.81124674
30MP0001970_abnormal_pain_threshold1.79461135
31MP0002837_dystrophic_cardiac_calcinosis1.79318382
32MP0001905_abnormal_dopamine_level1.76989418
33MP0000778_abnormal_nervous_system1.73399338
34MP0005410_abnormal_fertilization1.72952247
35MP0002557_abnormal_social/conspecific_i1.69920185
36MP0005645_abnormal_hypothalamus_physiol1.68991551
37MP0005646_abnormal_pituitary_gland1.65952526
38MP0005386_behavior/neurological_phenoty1.64712229
39MP0004924_abnormal_behavior1.64712229
40MP0003123_paternal_imprinting1.59834368
41MP0002653_abnormal_ependyma_morphology1.53800262
42MP0004811_abnormal_neuron_physiology1.45712440
43MP0004142_abnormal_muscle_tone1.45049508
44MP0004885_abnormal_endolymph1.44519053
45MP0003633_abnormal_nervous_system1.41403075
46MP0005499_abnormal_olfactory_system1.35215262
47MP0005394_taste/olfaction_phenotype1.35215262
48MP0002822_catalepsy1.27887326
49MP0002102_abnormal_ear_morphology1.23373743
50MP0003879_abnormal_hair_cell1.22726342
51MP0002882_abnormal_neuron_morphology1.21971182
52MP0000955_abnormal_spinal_cord1.20034456
53MP0008789_abnormal_olfactory_epithelium1.19733218
54MP0002066_abnormal_motor_capabilities/c1.19353060
55MP0003690_abnormal_glial_cell1.16119344
56MP0002638_abnormal_pupillary_reflex1.15173224
57MP0000920_abnormal_myelination1.13121814
58MP0010386_abnormal_urinary_bladder1.12935891
59MP0000631_abnormal_neuroendocrine_gland1.12734795
60MP0002876_abnormal_thyroid_physiology1.12614169
61MP0001177_atelectasis1.11067333
62MP0004145_abnormal_muscle_electrophysio1.07570980
63MP0003329_amyloid_beta_deposits1.07063367
64MP0003698_abnormal_male_reproductive1.06733718
65MP0002909_abnormal_adrenal_gland1.06618135
66MP0002152_abnormal_brain_morphology1.06065951
67MP0006035_abnormal_mitochondrial_morpho1.05379941
68MP0000751_myopathy1.05003543
69MP0006072_abnormal_retinal_apoptosis1.03916263
70MP0008569_lethality_at_weaning1.03730555
71MP0002751_abnormal_autonomic_nervous0.97824092
72MP0000604_amyloidosis0.97280153
73MP0000013_abnormal_adipose_tissue0.96863871
74MP0005551_abnormal_eye_electrophysiolog0.95848208
75MP0006292_abnormal_olfactory_placode0.95148356
76MP0001502_abnormal_circadian_rhythm0.89982541
77MP0004215_abnormal_myocardial_fiber0.87970972
78MP0002752_abnormal_somatic_nervous0.85846481
79MP0002163_abnormal_gland_morphology0.85592976
80MP0001727_abnormal_embryo_implantation0.84580732
81MP0001986_abnormal_taste_sensitivity0.84563377
82MP0004233_abnormal_muscle_weight0.83857819
83MP0001963_abnormal_hearing_physiology0.81021307
84MP0008872_abnormal_physiological_respon0.80487358
85MP0008874_decreased_physiological_sensi0.78804479
86MP0002069_abnormal_eating/drinking_beha0.78666994
87MP0003632_abnormal_nervous_system0.78568494
88MP0004085_abnormal_heartbeat0.78399298
89MP0003634_abnormal_glial_cell0.76724819
90MP0005379_endocrine/exocrine_gland_phen0.74090440
91MP0001929_abnormal_gametogenesis0.73124097
92MP0004147_increased_porphyrin_level0.72761377
93MP0002160_abnormal_reproductive_system0.72659804
94MP0008058_abnormal_DNA_repair0.72651189
95MP0003183_abnormal_peptide_metabolism0.70764211
96MP0000026_abnormal_inner_ear0.70663207
97MP0005167_abnormal_blood-brain_barrier0.68815457
98MP0003861_abnormal_nervous_system0.68742881
99MP0003137_abnormal_impulse_conducting0.67777617
100MP0009780_abnormal_chondrocyte_physiolo0.67504253
101MP0004130_abnormal_muscle_cell0.66140448
102MP0001485_abnormal_pinna_reflex0.65858848
103MP0004742_abnormal_vestibular_system0.63343761
104MP0002229_neurodegeneration0.63072234
105MP0004484_altered_response_of0.63014259
106MP0006036_abnormal_mitochondrial_physio0.61730572
107MP0001943_abnormal_respiration0.59653745
108MP0002161_abnormal_fertility/fecundity0.58643974
109MP0005535_abnormal_body_temperature0.57199453
110MP0003631_nervous_system_phenotype0.55493155
111MP0004858_abnormal_nervous_system0.54966913
112MP0005253_abnormal_eye_physiology0.54690091
113MP0002082_postnatal_lethality0.54361001
114MP0010770_preweaning_lethality0.54361001
115MP0010769_abnormal_survival0.52524691
116MP0002090_abnormal_vision0.52117460
117MP0010768_mortality/aging0.50704373
118MP0003956_abnormal_body_size0.49558768
119MP0004043_abnormal_pH_regulation0.49374027
120MP0005187_abnormal_penis_morphology0.48766293
121MP0000569_abnormal_digit_pigmentation0.46585534

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.14874730
2Atonic seizures (HP:0010819)4.85788700
3Acute necrotizing encephalopathy (HP:0006965)4.52290890
4Abnormal mitochondria in muscle tissue (HP:0008316)4.33443689
5Action tremor (HP:0002345)4.29944503
6Epileptic encephalopathy (HP:0200134)4.13463780
7Focal seizures (HP:0007359)4.11759924
8Febrile seizures (HP:0002373)4.08876853
9Supranuclear gaze palsy (HP:0000605)4.05013850
10Progressive macrocephaly (HP:0004481)3.83087305
11Absence seizures (HP:0002121)3.79793776
12Diplopia (HP:0000651)3.79740571
13Abnormality of binocular vision (HP:0011514)3.79740571
14Visual hallucinations (HP:0002367)3.73351341
15Hyperventilation (HP:0002883)3.67626018
16Abnormal hair whorl (HP:0010721)3.61897513
17Medial flaring of the eyebrow (HP:0010747)3.53388101
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.51745797
19Absent/shortened dynein arms (HP:0200106)3.51745797
20Mutism (HP:0002300)3.49848915
21Mitochondrial inheritance (HP:0001427)3.47885887
22Gait imbalance (HP:0002141)3.47241606
23Urinary urgency (HP:0000012)3.36914011
24Dialeptic seizures (HP:0011146)3.33923029
25Abnormality of the corticospinal tract (HP:0002492)3.30715096
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.26330963
27Acute encephalopathy (HP:0006846)3.23320149
28Progressive inability to walk (HP:0002505)3.20607582
29Myokymia (HP:0002411)3.18180117
30Cerebral hypomyelination (HP:0006808)3.16483744
31Congenital primary aphakia (HP:0007707)3.15516795
32Intention tremor (HP:0002080)3.02760641
33Progressive cerebellar ataxia (HP:0002073)3.02635926
34Degeneration of the lateral corticospinal tracts (HP:0002314)3.01300550
35Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.01300550
36Urinary bladder sphincter dysfunction (HP:0002839)3.00842308
37Nephrogenic diabetes insipidus (HP:0009806)2.99933592
38Peripheral hypomyelination (HP:0007182)2.96866764
39Increased CSF lactate (HP:0002490)2.95134099
40Neuroendocrine neoplasm (HP:0100634)2.92943609
41Abnormal respiratory motile cilium morphology (HP:0005938)2.89382641
42Abnormal respiratory epithelium morphology (HP:0012253)2.89382641
43Status epilepticus (HP:0002133)2.85446925
44Generalized tonic-clonic seizures (HP:0002069)2.84932106
45Postural instability (HP:0002172)2.80621746
46Neurofibrillary tangles (HP:0002185)2.80542770
47Lower limb muscle weakness (HP:0007340)2.79433541
48Pheochromocytoma (HP:0002666)2.79122702
49Hepatocellular necrosis (HP:0001404)2.79113281
50Dysmetria (HP:0001310)2.78876159
51Polyphagia (HP:0002591)2.78012614
52Abnormal respiratory motile cilium physiology (HP:0012261)2.73543461
53Abnormality of glycolysis (HP:0004366)2.72906300
54Increased serum pyruvate (HP:0003542)2.72906300
55Inability to walk (HP:0002540)2.68766694
56Abnormality of the labia minora (HP:0012880)2.65467894
57Limb dystonia (HP:0002451)2.63576077
58Abnormal ciliary motility (HP:0012262)2.61790694
59Broad-based gait (HP:0002136)2.57825861
60Neuronal loss in central nervous system (HP:0002529)2.57132373
61Torticollis (HP:0000473)2.57017676
62Depression (HP:0000716)2.55626237
63Akinesia (HP:0002304)2.46636710
64Spastic tetraplegia (HP:0002510)2.46527226
65Morphological abnormality of the pyramidal tract (HP:0002062)2.45569971
66Dysdiadochokinesis (HP:0002075)2.44838266
67Protruding tongue (HP:0010808)2.43944241
68Clonus (HP:0002169)2.43516001
69Vaginal atresia (HP:0000148)2.42333405
70Poor suck (HP:0002033)2.41589902
71Genital tract atresia (HP:0001827)2.41563231
72Failure to thrive in infancy (HP:0001531)2.41130450
73Hemiplegia (HP:0002301)2.39125285
74CNS hypomyelination (HP:0003429)2.38555874
75Optic disc pallor (HP:0000543)2.38387853
76Rhinitis (HP:0012384)2.37931639
77Sleep apnea (HP:0010535)2.36456253
78Amblyopia (HP:0000646)2.35722039
79Hemiparesis (HP:0001269)2.35581559
80Truncal ataxia (HP:0002078)2.33001933
81Bradykinesia (HP:0002067)2.31754047
82Impaired vibration sensation in the lower limbs (HP:0002166)2.28026927
83Specific learning disability (HP:0001328)2.25619279
84Epileptiform EEG discharges (HP:0011182)2.24851331
85Focal dystonia (HP:0004373)2.24443909
86Split foot (HP:0001839)2.24283941
87Poor coordination (HP:0002370)2.23421921
88Esotropia (HP:0000565)2.22837159
89Tetraplegia (HP:0002445)2.21258324
90Abnormality of the lower motor neuron (HP:0002366)2.19639449
91Molar tooth sign on MRI (HP:0002419)2.12607726
92Abnormality of midbrain morphology (HP:0002418)2.12607726
93Lissencephaly (HP:0001339)2.11955587
94Leukodystrophy (HP:0002415)2.11629134
95EEG with generalized epileptiform discharges (HP:0011198)2.10955545
96Abnormal eating behavior (HP:0100738)2.10337841
97Cerebral inclusion bodies (HP:0100314)2.10163904
98Abnormal social behavior (HP:0012433)2.09957634
99Impaired social interactions (HP:0000735)2.09957634
100Shoulder girdle muscle weakness (HP:0003547)2.09530366
101Exercise intolerance (HP:0003546)2.07729464
102Scanning speech (HP:0002168)2.07654900
103Generalized myoclonic seizures (HP:0002123)2.06917728
104Gaze-evoked nystagmus (HP:0000640)2.05871368
105Rapidly progressive (HP:0003678)2.05183018
106Aplasia/Hypoplasia of the brainstem (HP:0007362)2.04679543
107Hypoplasia of the brainstem (HP:0002365)2.04679543
108Absent speech (HP:0001344)2.03863690
109Aplasia/Hypoplasia of the lens (HP:0008063)2.03735942
110Ulnar claw (HP:0001178)2.03647644
111Impaired vibratory sensation (HP:0002495)2.03372647
112Retinal dysplasia (HP:0007973)2.00954026
113Apathy (HP:0000741)1.99023374
114Hypoplasia of the corpus callosum (HP:0002079)1.98493753
115Delusions (HP:0000746)1.98133238
116Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.97894026
117Nephronophthisis (HP:0000090)1.93167694
118Hypsarrhythmia (HP:0002521)1.92781483
119Abnormality of ocular smooth pursuit (HP:0000617)1.90482799
120Excessive salivation (HP:0003781)1.90326528
121Drooling (HP:0002307)1.90326528
122Diminished motivation (HP:0000745)1.90127868
123Craniofacial dystonia (HP:0012179)1.89938341
124Delayed gross motor development (HP:0002194)1.89158717
125Lactic acidosis (HP:0003128)1.88468878
126Muscular hypotonia of the trunk (HP:0008936)1.87550180
127Atrophy/Degeneration involving motor neurons (HP:0007373)1.87299397
128Hepatic necrosis (HP:0002605)1.85174100
129Anxiety (HP:0000739)1.84112617
130Cerebral edema (HP:0002181)1.82898562
131Poor eye contact (HP:0000817)1.81825175
132Paraplegia (HP:0010550)1.80780263
133Unsteady gait (HP:0002317)1.78663121
134Agitation (HP:0000713)1.78290357
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.77717235
136Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77451345
137Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77451345
138Hypothermia (HP:0002045)1.76591328
139Emotional lability (HP:0000712)1.75519359
140Amyotrophic lateral sclerosis (HP:0007354)1.75375221
141Papilledema (HP:0001085)1.74175177
142Short tibia (HP:0005736)1.73580021
143Postaxial hand polydactyly (HP:0001162)1.73329833
144Ankle clonus (HP:0011448)1.72566279
145Fetal akinesia sequence (HP:0001989)1.71733468
146Spastic gait (HP:0002064)1.71659434
147Increased serum lactate (HP:0002151)1.70212700
148Respiratory failure (HP:0002878)1.69442839
149Infertility (HP:0000789)1.68344952
150Oligomenorrhea (HP:0000876)1.67941291
151Broad foot (HP:0001769)1.67903166
152Impaired smooth pursuit (HP:0007772)1.67862842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.14513547
2MAP3K123.53269388
3MAP2K73.42617986
4NTRK33.22409238
5MAP3K43.10071413
6MARK12.78912409
7CCNB12.47135726
8CDK192.43873669
9MINK12.36746076
10TSSK62.27532345
11SIK32.27035081
12PLK22.24185414
13EPHA42.22509006
14NTRK22.11181032
15MAP4K21.98168039
16PINK11.89608016
17MAP3K91.88042659
18PNCK1.85809388
19STK161.84280171
20NME11.79091427
21MAP2K41.77950807
22MAPK131.74425745
23PDK31.74289363
24PDK41.74289363
25DAPK11.68625944
26ARAF1.67523475
27GRK51.42480774
28CAMKK21.41577785
29KSR11.37866878
30BRAF1.35304431
31DAPK21.30522496
32AKT31.26568476
33BUB11.26046341
34BCR1.24980446
35PAK31.24829456
36RIPK41.23184987
37EPHA31.22595506
38PRKCG1.22205634
39MAP3K111.21805187
40TESK21.12717344
41DYRK21.08886236
42TRIM281.08554227
43UHMK11.04334995
44LIMK11.03538873
45TNIK1.01648219
46SRPK11.01645582
47PLK30.98777264
48OXSR10.98614082
49CDK50.96466670
50CDK180.94522565
51CAMK2A0.92605078
52ERBB30.92333986
53PTK2B0.91277262
54BMPR20.90971137
55PRPF4B0.88821042
56CSNK1A1L0.85307915
57CAMK2B0.85115905
58CDK140.85036298
59MARK20.84908327
60SIK20.83429920
61BCKDK0.83041827
62CDK150.81229689
63CAMK40.80490520
64DYRK1A0.80187966
65BRSK10.79631834
66MAP3K60.78191903
67VRK10.77119104
68MAPK120.75373080
69EIF2AK10.75164660
70ADRBK10.75135701
71TYRO30.72375560
72CDK11A0.70840179
73DYRK1B0.70797152
74PAK60.69286844
75PRKCH0.68819148
76PDK20.67738606
77NEK10.67730761
78FES0.67341355
79ADRBK20.65386414
80PRKCE0.65156088
81STK380.64399022
82NEK60.63932837
83TXK0.63048229
84CSNK1G20.62477767
85DYRK30.62332841
86CSNK1G10.61767808
87BMPR1B0.61584688
88CAMK2G0.61527061
89MYLK0.61014840
90STK110.60850406
91RAF10.58600700
92CDK30.58039554
93CDK80.57985087
94PKN10.56081126
95NTRK10.52626331
96PRKCZ0.52248109
97SGK10.52012368
98MAP3K50.51000324
99GRK70.50790659
100TNK20.49757190
101YES10.48830680
102KSR20.48273601
103GRK60.47634970
104TAOK30.46794006
105SGK4940.46007244
106SGK2230.46007244
107CSNK1G30.45769888
108WEE10.45188060
109SGK20.45167910
110LATS20.45096328
111MAPK100.45058432
112RPS6KA30.44186702
113WNK30.43043564
114MUSK0.42657387
115CAMK2D0.42342968
116PDK10.40473988
117FYN0.40265828
118ALK0.38984044
119SCYL20.38861307
120AURKA0.38851038
121CAMKK10.37591699
122LMTK20.37355148
123EIF2AK30.36934249
124PRKD30.35843884
125TAOK10.35825474
126BRSK20.35291289
127MAPKAPK50.34691320
128CAMK10.34622114
129PHKG10.33842743
130PHKG20.33842743
131RPS6KA20.32965663
132DAPK30.32612080
133STK240.32418055
134MAPK40.31498637
135TESK10.30728022
136JAK20.29956740
137SGK30.29858820
138PRKCA0.29664743
139PRKACA0.29642907
140ROCK20.28033137
141ERBB40.26682052
142PASK0.26021889

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.11647381
2Oxidative phosphorylation_Homo sapiens_hsa001903.64496316
3Synaptic vesicle cycle_Homo sapiens_hsa047213.52333858
4Collecting duct acid secretion_Homo sapiens_hsa049663.22139712
5Parkinsons disease_Homo sapiens_hsa050122.96516401
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53349021
7Huntingtons disease_Homo sapiens_hsa050162.35228095
8Alzheimers disease_Homo sapiens_hsa050102.33201192
9Olfactory transduction_Homo sapiens_hsa047402.29229564
10Vibrio cholerae infection_Homo sapiens_hsa051102.28886701
11Proteasome_Homo sapiens_hsa030502.25291924
12GABAergic synapse_Homo sapiens_hsa047272.22488909
13Amphetamine addiction_Homo sapiens_hsa050312.12750662
14Morphine addiction_Homo sapiens_hsa050322.11282642
15Long-term potentiation_Homo sapiens_hsa047202.07222782
16Taste transduction_Homo sapiens_hsa047422.02667688
17Circadian entrainment_Homo sapiens_hsa047132.02300240
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.92030557
19Dopaminergic synapse_Homo sapiens_hsa047281.88447162
20Cardiac muscle contraction_Homo sapiens_hsa042601.84754784
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.83990269
22Glutamatergic synapse_Homo sapiens_hsa047241.81451317
23Serotonergic synapse_Homo sapiens_hsa047261.65925915
24Long-term depression_Homo sapiens_hsa047301.52068806
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47068356
26Renin secretion_Homo sapiens_hsa049241.40953100
27Salivary secretion_Homo sapiens_hsa049701.36884987
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35874925
29Insulin secretion_Homo sapiens_hsa049111.35489399
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29358918
31Calcium signaling pathway_Homo sapiens_hsa040201.28811398
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28540064
33Cholinergic synapse_Homo sapiens_hsa047251.27263954
34Cocaine addiction_Homo sapiens_hsa050301.26327092
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24163217
36Oocyte meiosis_Homo sapiens_hsa041141.22508270
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21767604
38RNA polymerase_Homo sapiens_hsa030201.12456870
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11694858
40Oxytocin signaling pathway_Homo sapiens_hsa049211.08673663
41Regulation of autophagy_Homo sapiens_hsa041401.08302930
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08033440
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03962691
44Gap junction_Homo sapiens_hsa045401.03136945
45Phototransduction_Homo sapiens_hsa047441.00641776
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00026064
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98233171
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96390421
49Pyruvate metabolism_Homo sapiens_hsa006200.92509153
50Gastric acid secretion_Homo sapiens_hsa049710.90233055
51Protein export_Homo sapiens_hsa030600.83566402
52Rheumatoid arthritis_Homo sapiens_hsa053230.76458173
53Type I diabetes mellitus_Homo sapiens_hsa049400.72235728
54Phagosome_Homo sapiens_hsa041450.71782454
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71440696
56Axon guidance_Homo sapiens_hsa043600.69351605
57Butanoate metabolism_Homo sapiens_hsa006500.69258067
58Alcoholism_Homo sapiens_hsa050340.66472714
59GnRH signaling pathway_Homo sapiens_hsa049120.66266568
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66011306
61Estrogen signaling pathway_Homo sapiens_hsa049150.65623172
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64781179
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64234995
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64052813
65Purine metabolism_Homo sapiens_hsa002300.63703573
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.62830394
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62245767
68cAMP signaling pathway_Homo sapiens_hsa040240.60440511
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55883517
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55630358
71Glucagon signaling pathway_Homo sapiens_hsa049220.55562721
72ErbB signaling pathway_Homo sapiens_hsa040120.55536433
73Spliceosome_Homo sapiens_hsa030400.54002789
74Melanogenesis_Homo sapiens_hsa049160.53812263
75Endocytosis_Homo sapiens_hsa041440.52428975
76RNA transport_Homo sapiens_hsa030130.51395274
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50631513
78Pyrimidine metabolism_Homo sapiens_hsa002400.49888588
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.49319130
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46337299
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.45798539
82Inositol phosphate metabolism_Homo sapiens_hsa005620.45640722
83Basal transcription factors_Homo sapiens_hsa030220.45359205
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44916114
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42297567
86N-Glycan biosynthesis_Homo sapiens_hsa005100.42283405
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41185995
88Glioma_Homo sapiens_hsa052140.40525945
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40402527
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40053901
91Nucleotide excision repair_Homo sapiens_hsa034200.39156436
92Rap1 signaling pathway_Homo sapiens_hsa040150.38578125
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37927045
94Choline metabolism in cancer_Homo sapiens_hsa052310.37274418
95MAPK signaling pathway_Homo sapiens_hsa040100.37035224
96Thyroid hormone synthesis_Homo sapiens_hsa049180.35909493
97VEGF signaling pathway_Homo sapiens_hsa043700.35722052
98RNA degradation_Homo sapiens_hsa030180.35651291
99AMPK signaling pathway_Homo sapiens_hsa041520.35562624
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.34670078
101Epstein-Barr virus infection_Homo sapiens_hsa051690.33093926
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32051731
103mRNA surveillance pathway_Homo sapiens_hsa030150.31701354
104Type II diabetes mellitus_Homo sapiens_hsa049300.30689672
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30054490
106Phenylalanine metabolism_Homo sapiens_hsa003600.29880267
107Mismatch repair_Homo sapiens_hsa034300.29795150
108Bile secretion_Homo sapiens_hsa049760.29657303
109Dilated cardiomyopathy_Homo sapiens_hsa054140.29456120
110Colorectal cancer_Homo sapiens_hsa052100.26207500
111Cell cycle_Homo sapiens_hsa041100.25487229
112Prion diseases_Homo sapiens_hsa050200.25384430
113Salmonella infection_Homo sapiens_hsa051320.25202183
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24662799
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24638620
116Circadian rhythm_Homo sapiens_hsa047100.24051009
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23919509
118Wnt signaling pathway_Homo sapiens_hsa043100.22219606
119Insulin signaling pathway_Homo sapiens_hsa049100.22004275
120Fanconi anemia pathway_Homo sapiens_hsa034600.21341935
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20565927
122Fatty acid biosynthesis_Homo sapiens_hsa000610.20443398
123Arginine and proline metabolism_Homo sapiens_hsa003300.19672166
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19497294
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18217885
126Ras signaling pathway_Homo sapiens_hsa040140.17986335
127beta-Alanine metabolism_Homo sapiens_hsa004100.17957703
128DNA replication_Homo sapiens_hsa030300.17601850
129Pancreatic secretion_Homo sapiens_hsa049720.17053758
130Chemokine signaling pathway_Homo sapiens_hsa040620.17035251
131Metabolic pathways_Homo sapiens_hsa011000.14304677
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.13771594

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