MOB3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.23311838
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.23311838
3antigen processing and presentation of endogenous antigen (GO:0019883)6.09715418
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.60121116
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.60121116
6modulation by symbiont of host immune response (GO:0052553)5.60121116
7positive regulation by symbiont of host defense response (GO:0052509)5.60121116
8modulation by symbiont of host defense response (GO:0052031)5.60121116
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.60121116
10positive regulation of gamma-delta T cell activation (GO:0046645)5.36947115
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.78297870
12detection of other organism (GO:0098543)4.74744214
13detection of bacterium (GO:0016045)4.67612840
14negative thymic T cell selection (GO:0045060)4.56364833
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.54443216
16NIK/NF-kappaB signaling (GO:0038061)4.53739788
17macrophage activation involved in immune response (GO:0002281)4.53558765
18negative T cell selection (GO:0043383)4.50433880
19regulation of B cell receptor signaling pathway (GO:0050855)4.21160162
20leukocyte aggregation (GO:0070486)4.17639657
21negative regulation of lymphocyte mediated immunity (GO:0002707)4.16089145
22regulation of interferon-beta biosynthetic process (GO:0045357)4.14849918
23negative regulation of interleukin-12 production (GO:0032695)4.07786863
24regulation of gamma-delta T cell differentiation (GO:0045586)4.02636824
25detection of external biotic stimulus (GO:0098581)3.97854783
26Arp2/3 complex-mediated actin nucleation (GO:0034314)3.91344304
27response to host immune response (GO:0052572)3.85634184
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.85634184
29antigen processing and presentation via MHC class Ib (GO:0002475)3.85264212
30regulation of interleukin-12 biosynthetic process (GO:0045075)3.81796434
31regulation of B cell differentiation (GO:0045577)3.76450309
32negative regulation of T cell mediated immunity (GO:0002710)3.75884801
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.75735031
34regulation of gamma-delta T cell activation (GO:0046643)3.72722930
35negative regulation of leukocyte mediated immunity (GO:0002704)3.72255773
36ribosomal small subunit assembly (GO:0000028)3.68753231
37positive regulation of B cell differentiation (GO:0045579)3.67814646
38detection of molecule of bacterial origin (GO:0032490)3.65779517
39positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.61308240
40response to interleukin-15 (GO:0070672)3.60667471
41positive thymic T cell selection (GO:0045059)3.59191571
42response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.55970006
43response to host (GO:0075136)3.55970006
44response to host defenses (GO:0052200)3.55970006
45thymic T cell selection (GO:0045061)3.55326523
46myeloid dendritic cell activation (GO:0001773)3.51751920
47detection of biotic stimulus (GO:0009595)3.50311090
48interferon-gamma production (GO:0032609)3.49431582
49negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.48336340
50myeloid cell activation involved in immune response (GO:0002275)3.46269966
51negative regulation of phagocytosis (GO:0050765)3.43470946
52immunoglobulin mediated immune response (GO:0016064)3.42989671
53T cell migration (GO:0072678)3.40024397
54regulation of mast cell degranulation (GO:0043304)3.36443685
55germinal center formation (GO:0002467)3.34764808
56cellular response to interleukin-15 (GO:0071350)3.34113660
57microglial cell activation (GO:0001774)3.33548303
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.32744819
59T cell selection (GO:0045058)3.32067521
60response to type I interferon (GO:0034340)3.30521419
61type I interferon signaling pathway (GO:0060337)3.30479308
62cellular response to type I interferon (GO:0071357)3.30479308
63myeloid dendritic cell differentiation (GO:0043011)3.30006950
64neutrophil activation involved in immune response (GO:0002283)3.28163069
65positive regulation of antigen processing and presentation (GO:0002579)3.27901537
66sequestering of actin monomers (GO:0042989)3.27077125
67B cell receptor signaling pathway (GO:0050853)3.26594498
68regulation of alpha-beta T cell proliferation (GO:0046640)3.25917823
69regulation of T cell mediated cytotoxicity (GO:0001914)3.24638147
70leukocyte migration involved in inflammatory response (GO:0002523)3.23954794
71positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.22704349
72negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.22431561
73negative regulation of cell killing (GO:0031342)3.22431561
74regulation of T cell tolerance induction (GO:0002664)3.22334057
75positive regulation of T cell mediated cytotoxicity (GO:0001916)3.20575858
76regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.16660884
77regulation of T cell receptor signaling pathway (GO:0050856)3.15719111
78cellular response to zinc ion (GO:0071294)3.14554607
79T cell homeostasis (GO:0043029)3.14244508
80neutrophil mediated immunity (GO:0002446)3.13973268
81positive regulation of mast cell activation (GO:0033005)3.13648986
82macrophage activation (GO:0042116)3.10867264
83positive regulation of natural killer cell differentiation (GO:0032825)3.10145945
84interferon-gamma-mediated signaling pathway (GO:0060333)3.09585775
85B cell mediated immunity (GO:0019724)3.09428199
86positive regulation of interleukin-2 production (GO:0032743)3.08818934
87regulation of mast cell activation involved in immune response (GO:0033006)3.08281280
88mast cell activation (GO:0045576)3.07847675
89T cell costimulation (GO:0031295)3.07412601
90leukocyte degranulation (GO:0043299)3.04534486
91regulation of antigen processing and presentation (GO:0002577)3.03381804
92positive regulation of alpha-beta T cell proliferation (GO:0046641)3.02858613
93lymphocyte costimulation (GO:0031294)3.02831802
94negative regulation of innate immune response (GO:0045824)3.00872297
95regulation of mast cell activation (GO:0033003)3.00431753
96regulation of myeloid leukocyte mediated immunity (GO:0002886)2.98879101
97negative regulation of erythrocyte differentiation (GO:0045647)2.98247952
98regulation of necroptotic process (GO:0060544)2.97377854
99neutrophil activation (GO:0042119)2.96954640
100defense response to protozoan (GO:0042832)2.96102810
101negative regulation of alpha-beta T cell activation (GO:0046636)2.96021820
102positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.94448018
103regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93896746
104regulation of type I interferon-mediated signaling pathway (GO:0060338)2.93801330
105negative regulation of interleukin-6 production (GO:0032715)2.92630518
106positive regulation of interferon-alpha production (GO:0032727)2.92527805
107cellular response to interferon-beta (GO:0035458)2.91898901
108B cell homeostasis (GO:0001782)2.91199927
109antigen receptor-mediated signaling pathway (GO:0050851)2.91019040
110regulation of leukocyte degranulation (GO:0043300)2.90543637
111regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.90526138
112natural killer cell activation (GO:0030101)2.90491811
113negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.89692041
114negative regulation of T-helper cell differentiation (GO:0045623)2.89692041
115actin nucleation (GO:0045010)2.89522372
116response to protozoan (GO:0001562)2.89370634
117positive T cell selection (GO:0043368)2.89266769
118regulation of response to interferon-gamma (GO:0060330)2.88899275
119regulation of T-helper 1 cell differentiation (GO:0045625)2.87618319
120positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.86872005
121T cell receptor signaling pathway (GO:0050852)2.83637093
122regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.83106233
123dendritic cell differentiation (GO:0097028)2.82791958
124leukocyte cell-cell adhesion (GO:0007159)2.82179566
125response to interferon-beta (GO:0035456)2.81721071
126regulation of RIG-I signaling pathway (GO:0039535)2.79393891
127regulation of interleukin-2 biosynthetic process (GO:0045076)2.78207617
128response to muramyl dipeptide (GO:0032495)2.77896678
129natural killer cell differentiation (GO:0001779)2.76380978
130lymphocyte homeostasis (GO:0002260)2.75886416
131JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.74700753
132megakaryocyte development (GO:0035855)2.74396757
133regulation of tolerance induction (GO:0002643)2.73371374
134tolerance induction (GO:0002507)2.72369806
135granulocyte activation (GO:0036230)2.71535813
136positive regulation of macrophage differentiation (GO:0045651)2.69174193
137positive regulation of lamellipodium assembly (GO:0010592)2.68296616
138respiratory burst (GO:0045730)2.67709233
139regulation of natural killer cell differentiation (GO:0032823)2.66756971
140positive regulation of isotype switching (GO:0045830)2.64475236
141response to peptidoglycan (GO:0032494)2.64149513
142necroptotic process (GO:0070266)2.62983879
143mature B cell differentiation (GO:0002335)2.61687471
144leukocyte homeostasis (GO:0001776)2.61251296
145cellular extravasation (GO:0045123)2.56337320
146regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.54691926
147regulation of natural killer cell mediated immunity (GO:0002715)2.54691926
148mature B cell differentiation involved in immune response (GO:0002313)2.54068229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.62759050
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.47554697
3E2F7_22180533_ChIP-Seq_HELA_Human4.32988823
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.82552637
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.79526453
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.69561391
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.40720359
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.28453170
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.10456691
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.87404415
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76971723
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.76445356
13MYC_22102868_ChIP-Seq_BL_Human2.75413753
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.63088622
15VDR_21846776_ChIP-Seq_THP-1_Human2.57801189
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.57571549
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52241400
18SCL_19346495_ChIP-Seq_HPC-7_Human2.47722687
19MYB_26560356_Chip-Seq_TH2_Human2.46745354
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45809687
21MAF_26560356_Chip-Seq_TH1_Human2.40563586
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.38549636
23SPI1_23547873_ChIP-Seq_NB4_Human2.36130085
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27735063
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26204454
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24021100
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.18521915
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18337365
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17064809
30RUNX_20019798_ChIP-Seq_JUKART_Human2.16287495
31MYB_26560356_Chip-Seq_TH1_Human2.12697375
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.10842172
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00623753
34UTX_26944678_Chip-Seq_JUKART_Human1.99105286
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.97157533
36VDR_24763502_ChIP-Seq_THP-1_Human1.93995806
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86881672
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86508376
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84983456
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.83491106
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.77821722
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72850814
43TCF7_22412390_ChIP-Seq_EML_Mouse1.63634913
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60091003
45MAF_26560356_Chip-Seq_TH2_Human1.56027203
46VDR_24787735_ChIP-Seq_THP-1_Human1.53426342
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51557052
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50195995
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49847577
50SPI1_23127762_ChIP-Seq_K562_Human1.48748605
51LXR_22292898_ChIP-Seq_THP-1_Human1.46081517
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45167234
53GATA3_27048872_Chip-Seq_THYMUS_Human1.45160947
54CIITA_25753668_ChIP-Seq_RAJI_Human1.45126337
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43061573
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39206417
57VDR_23849224_ChIP-Seq_CD4+_Human1.38907920
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37377509
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36686744
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34602832
61GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.33342131
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33094689
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.31971244
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31352017
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30132740
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29595729
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.27906443
68BCL6_27268052_Chip-Seq_Bcells_Human1.26896676
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26397917
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25927070
71GABP_17652178_ChIP-ChIP_JURKAT_Human1.25029479
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.24015148
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23863658
74PU_27001747_Chip-Seq_BMDM_Mouse1.23021623
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22359098
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.21083720
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21025307
78KDM2B_26808549_Chip-Seq_JURKAT_Human1.20686726
79FOXP3_21729870_ChIP-Seq_TREG_Human1.20490007
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16098471
81BCOR_27268052_Chip-Seq_Bcells_Human1.16027235
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14742443
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12527136
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12001178
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11606578
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10292747
87KDM2B_26808549_Chip-Seq_DND41_Human1.09954443
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08427666
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07281962
90GATA1_19941826_ChIP-Seq_K562_Human1.06345185
91ELK1_19687146_ChIP-ChIP_HELA_Human1.05155967
92XRN2_22483619_ChIP-Seq_HELA_Human1.05096326
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05006683
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05004684
95EST1_17652178_ChIP-ChIP_JURKAT_Human1.04629285
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03051648
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02487267
98GATA3_26560356_Chip-Seq_TH2_Human0.99636069
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99217611
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98932408
101CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97101737
102ELF1_20517297_ChIP-Seq_JURKAT_Human0.97097866
103PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96190762
104GATA1_22025678_ChIP-Seq_K562_Human0.95081260
105RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93809492
106KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93598253
107TFEB_21752829_ChIP-Seq_HELA_Human0.92881031
108GATA2_21666600_ChIP-Seq_HMVEC_Human0.91285418
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.90659485
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90374088
111MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90171399
112PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89644640
113SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88769490
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88451883
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88348272
116SA1_27219007_Chip-Seq_ERYTHROID_Human0.87791280
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87273096
118CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86263163
119FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85155072
120E2F1_21310950_ChIP-Seq_MCF-7_Human0.82176935
121NELFA_20434984_ChIP-Seq_ESCs_Mouse0.81802988
122DCP1A_22483619_ChIP-Seq_HELA_Human0.81667529
123MYC_19079543_ChIP-ChIP_MESCs_Mouse0.81341680
124NCOR1_26117541_ChIP-Seq_K562_Human0.80607324
125JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.80424040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.60095721
2MP0000685_abnormal_immune_system3.84322103
3MP0005671_abnormal_response_to3.53783127
4MP0003763_abnormal_thymus_physiology3.25276482
5MP0003436_decreased_susceptibility_to3.05306209
6MP0009785_altered_susceptibility_to3.02298458
7MP0005387_immune_system_phenotype3.00172904
8MP0001790_abnormal_immune_system3.00172904
9MP0001800_abnormal_humoral_immune2.98353506
10MP0005000_abnormal_immune_tolerance2.86019651
11MP0002396_abnormal_hematopoietic_system2.76031899
12MP0002452_abnormal_antigen_presenting2.72660003
13MP0002420_abnormal_adaptive_immunity2.67495819
14MP0002148_abnormal_hypersensitivity_rea2.66014400
15MP0001819_abnormal_immune_cell2.65939097
16MP0002723_abnormal_immune_serum2.62665763
17MP0005025_abnormal_response_to2.60036440
18MP0002166_altered_tumor_susceptibility2.59089733
19MP0002398_abnormal_bone_marrow2.53024283
20MP0002419_abnormal_innate_immunity2.39500610
21MP0000716_abnormal_immune_system2.25583033
22MP0009333_abnormal_splenocyte_physiolog2.25437889
23MP0002405_respiratory_system_inflammati2.23976058
24MP0001873_stomach_inflammation2.11141657
25MP0001853_heart_inflammation2.09924181
26MP0004510_myositis2.08221932
27MP0002006_tumorigenesis2.08214287
28MP0000689_abnormal_spleen_morphology2.02487041
29MP0002722_abnormal_immune_system1.99728546
30MP0003303_peritoneal_inflammation1.99559326
31MP0005464_abnormal_platelet_physiology1.97668505
32MP0002429_abnormal_blood_cell1.92722946
33MP0003724_increased_susceptibility_to1.90159049
34MP0006082_CNS_inflammation1.89669967
35MP0004808_abnormal_hematopoietic_stem1.89412063
36MP0010155_abnormal_intestine_physiology1.88734932
37MP0000703_abnormal_thymus_morphology1.80711525
38MP0005397_hematopoietic_system_phenotyp1.70715335
39MP0001545_abnormal_hematopoietic_system1.70715335
40MP0003191_abnormal_cellular_cholesterol1.70538163
41MP0001348_abnormal_lacrimal_gland1.70107051
42MP0004947_skin_inflammation1.65555853
43MP0001845_abnormal_inflammatory_respons1.65416332
44MP0002933_joint_inflammation1.62647342
45MP0000465_gastrointestinal_hemorrhage1.59070440
46MP0003300_gastrointestinal_ulcer1.51649751
47MP0000490_abnormal_crypts_of1.51038711
48MP0005310_abnormal_salivary_gland1.50890881
49MP0008260_abnormal_autophagy1.49060139
50MP0003866_abnormal_defecation1.46617437
51MP0000858_altered_metastatic_potential1.45156657
52MP0004381_abnormal_hair_follicle1.44926975
53MP0001533_abnormal_skeleton_physiology1.44299996
54MP0010352_gastrointestinal_tract_polyps1.42987644
55MP0005174_abnormal_tail_pigmentation1.41758392
56MP0005451_abnormal_body_composition1.38900727
57MP0009278_abnormal_bone_marrow1.33747158
58MP0003448_altered_tumor_morphology1.23822031
59MP0002138_abnormal_hepatobiliary_system1.22647345
60MP0008469_abnormal_protein_level1.16505846
61MP0004883_abnormal_blood_vessel1.13792750
62MP0008007_abnormal_cellular_replicative1.12817118
63MP0008057_abnormal_DNA_replication1.10904731
64MP0002019_abnormal_tumor_incidence1.03427858
65MP0003075_altered_response_to1.03251558
66MP0003045_fibrosis0.96400185
67MP0000343_altered_response_to0.96392493
68MP0005075_abnormal_melanosome_morpholog0.96092056
69MP0002163_abnormal_gland_morphology0.95886041
70MP0005058_abnormal_lysosome_morphology0.94201792
71MP0003077_abnormal_cell_cycle0.92394135
72MP0003172_abnormal_lysosome_physiology0.92340770
73MP0005166_decreased_susceptibility_to0.91208663
74MP0002009_preneoplasia0.89898647
75MP0002095_abnormal_skin_pigmentation0.89857064
76MP0006054_spinal_hemorrhage0.88092094
77MP0009764_decreased_sensitivity_to0.86311603
78MP0005023_abnormal_wound_healing0.85540495
79MP0003183_abnormal_peptide_metabolism0.85480651
80MP0005164_abnormal_response_to0.84990348
81MP0010094_abnormal_chromosome_stability0.82397353
82MP0003693_abnormal_embryo_hatching0.81775505
83MP0002132_abnormal_respiratory_system0.81126812
84MP0000015_abnormal_ear_pigmentation0.80909068
85MP0003566_abnormal_cell_adhesion0.79721327
86MP0005076_abnormal_cell_differentiation0.78927810
87MP0010307_abnormal_tumor_latency0.74858842
88MP0001851_eye_inflammation0.74359425
89MP0002998_abnormal_bone_remodeling0.72415779
90MP0003279_aneurysm0.71793701
91MP0005390_skeleton_phenotype0.71442304
92MP0002877_abnormal_melanocyte_morpholog0.70523865
93MP0003091_abnormal_cell_migration0.66787368
94MP0000313_abnormal_cell_death0.66699574
95MP0000604_amyloidosis0.66239889
96MP0003690_abnormal_glial_cell0.63544767
97MP0001986_abnormal_taste_sensitivity0.62582162
98MP0009763_increased_sensitivity_to0.62239172
99MP0008058_abnormal_DNA_repair0.62073248
100MP0002277_abnormal_respiratory_mucosa0.61975310
101MP0002254_reproductive_system_inflammat0.61960081
102MP0008874_decreased_physiological_sensi0.61025082
103MP0000249_abnormal_blood_vessel0.60262541
104MP0001663_abnormal_digestive_system0.59718980
105MP0003656_abnormal_erythrocyte_physiolo0.59278440
106MP0003795_abnormal_bone_structure0.58269840
107MP0009765_abnormal_xenobiotic_induced0.58030970
108MP0008004_abnormal_stomach_pH0.57977062
109MP0003828_pulmonary_edema0.57788499
110MP0003943_abnormal_hepatobiliary_system0.57321647
111MP0009840_abnormal_foam_cell0.55821189
112MP0003111_abnormal_nucleus_morphology0.54711831
113MP0002693_abnormal_pancreas_physiology0.54684838
114MP0004957_abnormal_blastocyst_morpholog0.54496760
115MP0000569_abnormal_digit_pigmentation0.54474659
116MP0000350_abnormal_cell_proliferation0.53849009
117MP0001243_abnormal_dermal_layer0.53088596
118MP0002928_abnormal_bile_duct0.52103655
119MP0005381_digestive/alimentary_phenotyp0.47919265
120MP0000371_diluted_coat_color0.45754955
121MP0000609_abnormal_liver_physiology0.43552699
122MP0003221_abnormal_cardiomyocyte_apopto0.43191669
123MP0003806_abnormal_nucleotide_metabolis0.40628082
124MP0004130_abnormal_muscle_cell0.40154098
125MP0002133_abnormal_respiratory_system0.39369460

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.27879744
2Recurrent abscess formation (HP:0002722)4.99075681
3Chronic otitis media (HP:0000389)4.91679718
4Eczematoid dermatitis (HP:0000976)4.85025621
5Myositis (HP:0100614)4.78698922
6Recurrent bacterial skin infections (HP:0005406)4.48889530
7Recurrent fungal infections (HP:0002841)4.34708726
8Thrombocytosis (HP:0001894)4.26572400
9Recurrent viral infections (HP:0004429)4.11925227
10IgM deficiency (HP:0002850)4.08425212
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.05091605
12Recurrent bronchitis (HP:0002837)4.00423485
13Nasal polyposis (HP:0100582)3.71403074
14Abnormality of T cell number (HP:0011839)3.63948567
15Chronic mucocutaneous candidiasis (HP:0002728)3.59554768
16Recurrent cutaneous fungal infections (HP:0011370)3.59554768
17Panhypogammaglobulinemia (HP:0003139)3.54471192
18Abnormality of T cells (HP:0002843)3.50156397
19Recurrent skin infections (HP:0001581)3.49433927
20T lymphocytopenia (HP:0005403)3.43973494
21Abnormality of the nasal mucosa (HP:0000433)3.37944111
22Meningitis (HP:0001287)3.36365570
23Orchitis (HP:0100796)3.35830451
24Mediastinal lymphadenopathy (HP:0100721)3.33875508
25Abnormality of T cell physiology (HP:0011840)3.27648941
26Retrobulbar optic neuritis (HP:0100654)3.21055953
27Optic neuritis (HP:0100653)3.21055953
28Vasculitis (HP:0002633)3.19999137
29Cellulitis (HP:0100658)3.19213978
30Increased IgM level (HP:0003496)3.18331008
31Agammaglobulinemia (HP:0004432)3.15178592
32Hypochromic anemia (HP:0001931)3.14433992
33Hypochromic microcytic anemia (HP:0004840)3.13660028
34Petechiae (HP:0000967)3.12755475
35Autoimmune thrombocytopenia (HP:0001973)3.10833399
36IgG deficiency (HP:0004315)3.05123526
37Obstructive lung disease (HP:0006536)3.04330489
38Chronic obstructive pulmonary disease (HP:0006510)3.04330489
39Abnormality of cells of the lymphoid lineage (HP:0012140)3.04205244
40Lymphopenia (HP:0001888)2.99559922
41Abnormality of macrophages (HP:0004311)2.99422464
42Leukocytosis (HP:0001974)2.92601774
43Inflammation of the large intestine (HP:0002037)2.91866936
44Gastrointestinal inflammation (HP:0004386)2.91129235
45Hypergammaglobulinemia (HP:0010702)2.90095775
46Spontaneous hematomas (HP:0007420)2.87929524
47Eosinophilia (HP:0001880)2.85932570
48Episodic fever (HP:0001954)2.79881397
49Granulocytopenia (HP:0001913)2.74147633
50Increased IgE level (HP:0003212)2.67808981
51Pulmonary infiltrates (HP:0002113)2.65802243
52Recurrent gram-negative bacterial infections (HP:0005420)2.65304942
53Abnormality of eosinophils (HP:0001879)2.64282547
54Pustule (HP:0200039)2.62166774
55Encephalitis (HP:0002383)2.62123567
56Stomatitis (HP:0010280)2.59755888
57Anorexia (HP:0002039)2.56352133
58Chronic sinusitis (HP:0011109)2.56159422
59Interstitial pulmonary disease (HP:0006530)2.56007545
60Severe combined immunodeficiency (HP:0004430)2.55001211
61Sepsis (HP:0100806)2.53642172
62Fatigue (HP:0012378)2.51732711
63Pulmonary embolism (HP:0002204)2.51666025
64Arterial thrombosis (HP:0004420)2.47533012
65Colitis (HP:0002583)2.46644064
66Hemoptysis (HP:0002105)2.44377713
67IgA deficiency (HP:0002720)2.43298849
68Chronic diarrhea (HP:0002028)2.42931073
69Combined immunodeficiency (HP:0005387)2.42805651
70Abnormality of the pleura (HP:0002103)2.41908781
71Thyroiditis (HP:0100646)2.39988520
72Epistaxis (HP:0000421)2.39718044
73Aplastic anemia (HP:0001915)2.37629746
74Chest pain (HP:0100749)2.36740050
75Peritonitis (HP:0002586)2.36624999
76Microcytic anemia (HP:0001935)2.36225116
77Prolonged bleeding time (HP:0003010)2.34914884
78Lymphoma (HP:0002665)2.34479740
79Restrictive lung disease (HP:0002091)2.33240593
80Abnormality of the fingertips (HP:0001211)2.33181596
81Periodontitis (HP:0000704)2.27400839
82Gingivitis (HP:0000230)2.24240875
83Autoimmune hemolytic anemia (HP:0001890)2.23900061
84Abnormality of the peritoneum (HP:0002585)2.22485541
85Keratoconjunctivitis sicca (HP:0001097)2.22428326
86Skin ulcer (HP:0200042)2.21386897
87Gangrene (HP:0100758)2.17409060
88Emphysema (HP:0002097)2.15210472
89Keratoconjunctivitis (HP:0001096)2.14485228
90Gingival bleeding (HP:0000225)2.13788081
91Viral hepatitis (HP:0006562)2.13581882
92Bronchitis (HP:0012387)2.13564640
93Amaurosis fugax (HP:0100576)2.12327050
94Gastrointestinal stroma tumor (HP:0100723)2.12298695
95Purpura (HP:0000979)2.12229067
96B lymphocytopenia (HP:0010976)2.10915139
97Abnormality of B cell number (HP:0010975)2.10915139
98Urticaria (HP:0001025)2.10301104
99Amyloidosis (HP:0011034)2.07825279
100Premature loss of primary teeth (HP:0006323)2.07712920
101Osteomyelitis (HP:0002754)2.07204939
102Skin rash (HP:0000988)2.06753811
103Glomerulopathy (HP:0100820)2.05032352
104Arthralgia (HP:0002829)2.04570336
105Abnormality of the prostate (HP:0008775)2.04284886
106Reticulocytopenia (HP:0001896)2.03087004
107Gastrointestinal infarctions (HP:0005244)2.02618220
108Keratitis (HP:0000491)1.99957485
109Papilloma (HP:0012740)1.99526558
110Verrucae (HP:0200043)1.99526558
111Abnormal platelet volume (HP:0011876)1.99440640
112Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98913498
113Joint swelling (HP:0001386)1.97892198
114Recurrent sinusitis (HP:0011108)1.97635710
115Recurrent lower respiratory tract infections (HP:0002783)1.96919787
116Abnormality of the endocardium (HP:0004306)1.95879409
117Vacuolated lymphocytes (HP:0001922)1.94041450
118Acute hepatic failure (HP:0006554)1.93716429
119Impaired platelet aggregation (HP:0003540)1.93551617
120Abnormal platelet function (HP:0011869)1.93551617
121Hematochezia (HP:0002573)1.91314775
122Abnormality of the pericardium (HP:0001697)1.91117247
123Hypertensive crisis (HP:0100735)1.89960506
124Hepatosplenomegaly (HP:0001433)1.88254263
125Recurrent pneumonia (HP:0006532)1.85865276
126Abnormality of cells of the erythroid lineage (HP:0012130)1.84964011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.62713658
2TXK3.33366646
3JAK32.96473320
4TYK22.90472431
5PRPF4B2.73763102
6MAP3K142.64087959
7KIT2.62402026
8ZAP702.52064181
9BLK2.44570438
10TBK12.42419590
11IRAK42.31457851
12BTK2.22125085
13STK102.20848280
14IKBKE2.13815996
15IKBKB1.90951667
16TEC1.85603097
17EEF2K1.83179158
18CSF1R1.82821634
19TESK21.80596653
20SYK1.80427388
21FLT31.74654082
22ITK1.70855690
23PIM21.62243842
24NME21.61847745
25JAK11.59122581
26TAOK11.59006122
27MAP3K111.55168263
28LCK1.52927540
29LRRK21.51624718
30MAP3K31.51494392
31SMG11.50769676
32MAP3K131.47118590
33GRK61.45838890
34FGFR41.45474941
35EPHB11.40858224
36FGR1.40689868
37KDR1.39946211
38RPS6KA41.34640020
39HCK1.28448085
40CSK1.27307954
41CLK11.25106278
42PIM11.22655809
43TGFBR21.21687050
44NLK1.21172424
45ERN11.20641409
46CHUK1.18748337
47MAP3K101.18681621
48PRKD21.11845921
49MAP2K31.10136160
50MAP3K11.08090926
51TGFBR11.05242977
52LYN1.02975473
53FGFR31.02244090
54MST41.00650038
55TESK10.97346272
56TAOK20.95982776
57SCYL20.95524098
58PKN20.93532460
59KSR20.93202760
60FES0.92826087
61TRIB30.92129926
62YES10.91124623
63ACVR1B0.86318667
64MARK20.86015097
65EPHA30.85371034
66PDK10.84731904
67IRAK10.84153629
68SIK30.80251658
69TRPM70.76202070
70MAPK120.73658959
71BMPR20.73013991
72CDK190.72313074
73EIF2AK10.70927465
74MAP3K120.70523941
75CDC42BPA0.68666049
76SIK20.68418593
77RIPK40.67989720
78MAPK70.66657475
79JAK20.66396076
80MAPKAPK20.65496331
81RPS6KB20.64020881
82PDPK10.63255313
83STK40.61651881
84IRAK20.61128831
85PTK2B0.60024988
86MAP3K70.58663772
87FYN0.57910870
88PAK40.57498137
89SIK10.57480702
90TAOK30.57262565
91PRKCQ0.56631638
92MATK0.55581217
93MARK30.54902414
94MAP3K80.54549902
95RPS6KA60.52600352
96NEK20.52589630
97CDK40.51832811
98IRAK30.49319221
99PRKCH0.46456296
100PTK60.46177694
101TTN0.45375144
102BUB10.44625505
103NEK90.44029514
104TNK20.43849982
105CAMKK10.43825664
106STK110.43514004
107DYRK30.43222853
108VRK10.42294736
109MAPK40.40817379
110RPS6KA50.39685589
111PIK3CG0.39606948
112ILK0.39244405
113MAP2K60.39142999
114MAPK110.37723092
115PRKCD0.36852460
116MAP3K50.36345479
117RPS6KC10.36144393
118RPS6KL10.36144393
119HIPK20.35883206
120PASK0.34127085
121SGK30.33354973
122ATR0.32864692
123ABL10.32707098
124CDK60.31769356
125EIF2AK30.31504958
126DYRK1B0.30996471
127MAP2K20.30229804
128BRSK20.30071654
129MAPKAPK30.29687785
130EIF2AK20.29661646
131RAF10.29655279
132CAMKK20.28491687
133CDC70.28397856
134CDK120.27648776
135DAPK20.25932976
136RET0.24495790
137LIMK10.23672279
138MAPK30.23176675

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.47167123
2Leishmaniasis_Homo sapiens_hsa051402.65228735
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.49246486
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.40747297
5Measles_Homo sapiens_hsa051622.38584866
6Allograft rejection_Homo sapiens_hsa053302.36162712
7Antigen processing and presentation_Homo sapiens_hsa046122.27309292
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16289520
9B cell receptor signaling pathway_Homo sapiens_hsa046622.03724580
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02626930
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.00161274
12Graft-versus-host disease_Homo sapiens_hsa053321.99995079
13DNA replication_Homo sapiens_hsa030301.98084066
14Osteoclast differentiation_Homo sapiens_hsa043801.96657683
15T cell receptor signaling pathway_Homo sapiens_hsa046601.94059380
16Shigellosis_Homo sapiens_hsa051311.80067815
17Hematopoietic cell lineage_Homo sapiens_hsa046401.78035800
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76704210
19Herpes simplex infection_Homo sapiens_hsa051681.74890212
20Ribosome_Homo sapiens_hsa030101.69994108
21Viral myocarditis_Homo sapiens_hsa054161.66826211
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66315910
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.64915276
24Toxoplasmosis_Homo sapiens_hsa051451.61112011
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49949124
26Autoimmune thyroid disease_Homo sapiens_hsa053201.48836168
27Apoptosis_Homo sapiens_hsa042101.47572864
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47554510
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.46061454
30Legionellosis_Homo sapiens_hsa051341.44433657
31Base excision repair_Homo sapiens_hsa034101.40741668
32Influenza A_Homo sapiens_hsa051641.39355214
33TNF signaling pathway_Homo sapiens_hsa046681.33084448
34Acute myeloid leukemia_Homo sapiens_hsa052211.32762888
35Hepatitis B_Homo sapiens_hsa051611.31555030
36Mismatch repair_Homo sapiens_hsa034301.31108179
37Pertussis_Homo sapiens_hsa051331.30937161
38Chemokine signaling pathway_Homo sapiens_hsa040621.30843569
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29148186
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.28615245
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21777774
42Malaria_Homo sapiens_hsa051441.20852983
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20542432
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20256959
45Epstein-Barr virus infection_Homo sapiens_hsa051691.18726859
46Tuberculosis_Homo sapiens_hsa051521.17853390
47Chronic myeloid leukemia_Homo sapiens_hsa052201.10773186
48Proteasome_Homo sapiens_hsa030501.10524596
49Salmonella infection_Homo sapiens_hsa051321.10011199
50p53 signaling pathway_Homo sapiens_hsa041151.09586186
51Asthma_Homo sapiens_hsa053101.07316461
52Other glycan degradation_Homo sapiens_hsa005111.01346328
53Viral carcinogenesis_Homo sapiens_hsa052030.99605390
54HTLV-I infection_Homo sapiens_hsa051660.98078044
55Pancreatic cancer_Homo sapiens_hsa052120.97626560
56Platelet activation_Homo sapiens_hsa046110.97090751
57Spliceosome_Homo sapiens_hsa030400.96523472
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96387673
59Homologous recombination_Homo sapiens_hsa034400.93065407
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90198762
61Small cell lung cancer_Homo sapiens_hsa052220.86949168
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86702564
63Type I diabetes mellitus_Homo sapiens_hsa049400.85942078
64Non-homologous end-joining_Homo sapiens_hsa034500.83958889
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83039042
66Cell cycle_Homo sapiens_hsa041100.81565462
67Nucleotide excision repair_Homo sapiens_hsa034200.80359584
68Hepatitis C_Homo sapiens_hsa051600.79507296
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79504925
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.75550427
71Staphylococcus aureus infection_Homo sapiens_hsa051500.74935433
72Renal cell carcinoma_Homo sapiens_hsa052110.73344775
73Prolactin signaling pathway_Homo sapiens_hsa049170.72183358
74Colorectal cancer_Homo sapiens_hsa052100.70784345
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69596579
76Pyrimidine metabolism_Homo sapiens_hsa002400.61428073
77Rheumatoid arthritis_Homo sapiens_hsa053230.59930115
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.58646388
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.56837010
80VEGF signaling pathway_Homo sapiens_hsa043700.56568817
81Notch signaling pathway_Homo sapiens_hsa043300.55991863
82Non-small cell lung cancer_Homo sapiens_hsa052230.53543931
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52846986
84FoxO signaling pathway_Homo sapiens_hsa040680.51599015
85Endometrial cancer_Homo sapiens_hsa052130.50281579
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50032431
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.50029554
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49989043
89MAPK signaling pathway_Homo sapiens_hsa040100.49394434
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49038128
91RNA degradation_Homo sapiens_hsa030180.48422786
92Phagosome_Homo sapiens_hsa041450.47750750
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47695989
94GnRH signaling pathway_Homo sapiens_hsa049120.47574230
95RNA polymerase_Homo sapiens_hsa030200.47423792
96RNA transport_Homo sapiens_hsa030130.47166780
97Choline metabolism in cancer_Homo sapiens_hsa052310.46058136
98African trypanosomiasis_Homo sapiens_hsa051430.45936369
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45289471
100Lysosome_Homo sapiens_hsa041420.45230462
101Dorso-ventral axis formation_Homo sapiens_hsa043200.43067462
102MicroRNAs in cancer_Homo sapiens_hsa052060.42205421
103Endocytosis_Homo sapiens_hsa041440.41959271
104Fanconi anemia pathway_Homo sapiens_hsa034600.39963344
105Pentose phosphate pathway_Homo sapiens_hsa000300.39876091
106Insulin resistance_Homo sapiens_hsa049310.38107586
107Inositol phosphate metabolism_Homo sapiens_hsa005620.36891923
108mTOR signaling pathway_Homo sapiens_hsa041500.36465478
109Prostate cancer_Homo sapiens_hsa052150.36446814
110HIF-1 signaling pathway_Homo sapiens_hsa040660.35932703
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35454243
112Pathways in cancer_Homo sapiens_hsa052000.35257683
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34503741
114Type II diabetes mellitus_Homo sapiens_hsa049300.34486665
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.34244162
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33813633
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33720139
118Amoebiasis_Homo sapiens_hsa051460.32104205
119Rap1 signaling pathway_Homo sapiens_hsa040150.31843966
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.31127366
121N-Glycan biosynthesis_Homo sapiens_hsa005100.31054326
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30143354
123Proteoglycans in cancer_Homo sapiens_hsa052050.30083723
124Systemic lupus erythematosus_Homo sapiens_hsa053220.29988702
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29740037
126ErbB signaling pathway_Homo sapiens_hsa040120.27817701

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