MOB3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the opposite strand as the interferon kappa precursor (IFNK) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.99427209
2central nervous system myelination (GO:0022010)8.99427209
3fatty acid elongation (GO:0030497)8.68351947
4cholesterol biosynthetic process (GO:0006695)5.76430920
5presynaptic membrane assembly (GO:0097105)5.23381754
6response to methylmercury (GO:0051597)5.15926888
7sterol biosynthetic process (GO:0016126)5.12895902
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.04091783
9L-phenylalanine catabolic process (GO:0006559)5.04091783
10long-chain fatty acid biosynthetic process (GO:0042759)5.01055917
11coenzyme catabolic process (GO:0009109)4.90599185
12long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.89880849
13amyloid precursor protein metabolic process (GO:0042982)4.80931692
14axon ensheathment (GO:0008366)4.79591336
15ensheathment of neurons (GO:0007272)4.79591336
16myelination (GO:0042552)4.78912789
17DNA double-strand break processing (GO:0000729)4.74230393
18very long-chain fatty acid metabolic process (GO:0000038)4.74033297
19postsynaptic membrane organization (GO:0001941)4.70207309
20fatty-acyl-CoA biosynthetic process (GO:0046949)4.55742751
21presynaptic membrane organization (GO:0097090)4.53123251
22isoprenoid biosynthetic process (GO:0008299)4.49455083
23L-phenylalanine metabolic process (GO:0006558)4.45044966
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.45044966
25long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.41752971
26regulation of lipoprotein metabolic process (GO:0050746)4.23848935
27fatty-acyl-CoA metabolic process (GO:0035337)4.22269708
28heme transport (GO:0015886)4.18119548
29myelin maintenance (GO:0043217)4.07799602
30cofactor catabolic process (GO:0051187)4.02926821
31aromatic amino acid family catabolic process (GO:0009074)3.97440119
32replication fork processing (GO:0031297)3.88989995
33limb bud formation (GO:0060174)3.88006035
34lactate metabolic process (GO:0006089)3.86896982
35negative regulation of epidermal cell differentiation (GO:0045605)3.82428530
36negative regulation of epidermis development (GO:0045683)3.76178925
37regulation of collateral sprouting (GO:0048670)3.74354566
38negative regulation of DNA-dependent DNA replication (GO:2000104)3.73109917
39thioester biosynthetic process (GO:0035384)3.73012267
40acyl-CoA biosynthetic process (GO:0071616)3.73012267
41amyloid precursor protein catabolic process (GO:0042987)3.66709914
42C4-dicarboxylate transport (GO:0015740)3.60626626
43nucleotide transmembrane transport (GO:1901679)3.58947709
44import into cell (GO:0098657)3.52929380
45response to lipoprotein particle (GO:0055094)3.51737402
46bile acid biosynthetic process (GO:0006699)3.50237507
47negative regulation of neurotransmitter transport (GO:0051589)3.42872369
48Sertoli cell development (GO:0060009)3.39046414
49alpha-linolenic acid metabolic process (GO:0036109)3.34998629
50glyoxylate metabolic process (GO:0046487)3.34296609
51iron coordination entity transport (GO:1901678)3.31858931
52glycerophospholipid catabolic process (GO:0046475)3.31814857
53neurotransmitter uptake (GO:0001504)3.31382150
54neuron cell-cell adhesion (GO:0007158)3.31028791
55cholesterol metabolic process (GO:0008203)3.27823054
56thioester metabolic process (GO:0035383)3.27505811
57acyl-CoA metabolic process (GO:0006637)3.27505811
58cerebral cortex radially oriented cell migration (GO:0021799)3.24330018
59negative regulation of neurotransmitter secretion (GO:0046929)3.23781998
60somite development (GO:0061053)3.23766704
61creatine metabolic process (GO:0006600)3.22351546
62olfactory bulb development (GO:0021772)3.21179137
63steroid biosynthetic process (GO:0006694)3.20787994
64L-amino acid import (GO:0043092)3.19876174
65establishment of mitochondrion localization (GO:0051654)3.19563193
66positive regulation of cellular amine metabolic process (GO:0033240)3.18720918
67somatic hypermutation of immunoglobulin genes (GO:0016446)3.16664366
68somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16664366
69amino acid import (GO:0043090)3.08646286
70sterol metabolic process (GO:0016125)3.05755330
71eye photoreceptor cell differentiation (GO:0001754)3.04581110
72photoreceptor cell differentiation (GO:0046530)3.04581110
73cellular response to cholesterol (GO:0071397)3.03784315
74regulation of cholesterol biosynthetic process (GO:0045540)3.03709623
75chromatin remodeling at centromere (GO:0031055)3.03430280
76sulfur amino acid catabolic process (GO:0000098)3.03409304
77negative regulation of transcription regulatory region DNA binding (GO:2000678)3.01373615
78regulation of guanylate cyclase activity (GO:0031282)3.00566851
79indole-containing compound catabolic process (GO:0042436)3.00063981
80indolalkylamine catabolic process (GO:0046218)3.00063981
81tryptophan catabolic process (GO:0006569)3.00063981
82regulation of nuclear cell cycle DNA replication (GO:0033262)2.99745923
83regulation of keratinocyte proliferation (GO:0010837)2.98202621
84tyrosine metabolic process (GO:0006570)2.97367511
85negative regulation of keratinocyte proliferation (GO:0010839)2.95471446
86bile acid metabolic process (GO:0008206)2.92304709
87regulation of cholesterol metabolic process (GO:0090181)2.92084205
88response to phenylpropanoid (GO:0080184)2.91069336
89lateral sprouting from an epithelium (GO:0060601)2.90540307
90maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89275357
91response to dietary excess (GO:0002021)2.89135952
92L-serine metabolic process (GO:0006563)2.88707100
93negative regulation of protein localization to cell surface (GO:2000009)2.87830730
94kidney morphogenesis (GO:0060993)2.86799245
95oligodendrocyte differentiation (GO:0048709)2.85358187
96water-soluble vitamin biosynthetic process (GO:0042364)2.85285965
97glutathione derivative biosynthetic process (GO:1901687)2.83714859
98glutathione derivative metabolic process (GO:1901685)2.83714859
99neurotransmitter-gated ion channel clustering (GO:0072578)2.83374514
100regulation of cytokine production involved in inflammatory response (GO:1900015)2.83044003
101alcohol biosynthetic process (GO:0046165)2.81057767
102CENP-A containing nucleosome assembly (GO:0034080)2.81019494
103aldehyde catabolic process (GO:0046185)2.79759628
104acetyl-CoA metabolic process (GO:0006084)2.78953807
105cholesterol efflux (GO:0033344)2.77830078
106DNA damage response, detection of DNA damage (GO:0042769)2.76608287
107aromatic amino acid family metabolic process (GO:0009072)2.75361553
108tryptophan metabolic process (GO:0006568)2.75273879
109very-low-density lipoprotein particle assembly (GO:0034379)2.74586527
110cellular modified amino acid catabolic process (GO:0042219)2.73840300
111centriole replication (GO:0007099)2.73583069
112protein neddylation (GO:0045116)2.72250251
113pyrimidine-containing compound transmembrane transport (GO:0072531)2.71743822
114positive regulation of guanylate cyclase activity (GO:0031284)2.71380422
115triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.71365614
116peptidyl-glutamic acid carboxylation (GO:0017187)2.71016547
117protein carboxylation (GO:0018214)2.71016547
118detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.70706002
119vocalization behavior (GO:0071625)2.69879110
120plasma lipoprotein particle clearance (GO:0034381)2.69092510
121ethanol oxidation (GO:0006069)2.68464004
122primary alcohol catabolic process (GO:0034310)2.67445512
123negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64845119
124negative regulation of translation, ncRNA-mediated (GO:0040033)2.64845119
125regulation of translation, ncRNA-mediated (GO:0045974)2.64845119
126transepithelial transport (GO:0070633)2.64626401
127positive regulation of oligodendrocyte differentiation (GO:0048714)2.64458696
128histone exchange (GO:0043486)2.64196345
129nucleotide transport (GO:0006862)2.64124522
130pyrimidine nucleobase catabolic process (GO:0006208)2.63960931
131nucleobase catabolic process (GO:0046113)2.63640346
132ethanol metabolic process (GO:0006067)2.62965174
133L-fucose catabolic process (GO:0042355)2.62929684
134fucose catabolic process (GO:0019317)2.62929684
135L-fucose metabolic process (GO:0042354)2.62929684
136mechanosensory behavior (GO:0007638)2.62692824
137GPI anchor metabolic process (GO:0006505)2.61735783
138DNA replication-independent nucleosome assembly (GO:0006336)2.59768121
139DNA replication-independent nucleosome organization (GO:0034724)2.59768121
140acidic amino acid transport (GO:0015800)2.58581596
141triglyceride biosynthetic process (GO:0019432)2.58425085
142L-ascorbic acid metabolic process (GO:0019852)2.58203734
143negative regulation of astrocyte differentiation (GO:0048712)2.57931764
144response to redox state (GO:0051775)2.57683003
145protein palmitoylation (GO:0018345)2.57313788
146acylglycerol biosynthetic process (GO:0046463)2.56747707
147neutral lipid biosynthetic process (GO:0046460)2.56747707
148cellular biogenic amine catabolic process (GO:0042402)2.56435026
149amine catabolic process (GO:0009310)2.56435026
150protein-cofactor linkage (GO:0018065)2.56375402
151opsonization (GO:0008228)2.55331887
152short-term memory (GO:0007614)2.55184309
153kynurenine metabolic process (GO:0070189)2.54417906
154cysteine metabolic process (GO:0006534)2.54402007
155negative regulation of DNA recombination (GO:0045910)2.51793912
156regulation of timing of cell differentiation (GO:0048505)2.51084273
157calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.50855173
158serine family amino acid biosynthetic process (GO:0009070)2.49684376
159vitamin A metabolic process (GO:0006776)2.48080264
160regulation of development, heterochronic (GO:0040034)2.48078184
161protein localization to kinetochore (GO:0034501)2.47440343
162otic vesicle formation (GO:0030916)2.47412843
163regulation of heat generation (GO:0031650)2.47326835
164transmission of nerve impulse (GO:0019226)2.45794016
165keratinocyte development (GO:0003334)2.45745786
166regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.43058859
167resolution of meiotic recombination intermediates (GO:0000712)2.42748243
168L-glutamate transport (GO:0015813)2.42703189
169cellular response to sterol (GO:0036315)2.42412426
170glial cell proliferation (GO:0014009)2.41349397
171serotonin metabolic process (GO:0042428)2.38887130
172DNA catabolic process, exonucleolytic (GO:0000738)2.38606983
173synapse assembly (GO:0007416)2.35714472
174G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.32607298
175positive regulation of glycoprotein biosynthetic process (GO:0010560)2.32503836
176serine family amino acid catabolic process (GO:0009071)2.31466953
177regulation of penile erection (GO:0060405)2.31428900
178kinetochore organization (GO:0051383)2.31425593
179synapsis (GO:0007129)2.31117433
180metaphase plate congression (GO:0051310)2.30761267
181DNA ligation (GO:0006266)2.30344418
182kinetochore assembly (GO:0051382)2.30171025
183DNA replication checkpoint (GO:0000076)2.30040259
184regulation of posttranscriptional gene silencing (GO:0060147)2.29999194
185regulation of gene silencing by miRNA (GO:0060964)2.29999194
186regulation of gene silencing by RNA (GO:0060966)2.29999194
187mitotic G2/M transition checkpoint (GO:0044818)2.29230795
188cranial nerve development (GO:0021545)2.27928413
189head development (GO:0060322)2.26721833
190photoreceptor cell maintenance (GO:0045494)2.25303354
191mitotic metaphase plate congression (GO:0007080)2.24961796

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.79533643
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.33008658
3EZH2_22144423_ChIP-Seq_EOC_Human3.29649007
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.27905123
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.11742877
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.86364403
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.68721868
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.58690880
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.47200946
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.35290708
11ZNF274_21170338_ChIP-Seq_K562_Hela2.32990393
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27741360
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.23968550
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.23968550
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.23968550
16SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.16294955
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.07874163
18FUS_26573619_Chip-Seq_HEK293_Human2.03157960
19GBX2_23144817_ChIP-Seq_PC3_Human1.96380571
20EWS_26573619_Chip-Seq_HEK293_Human1.92756188
21E2F7_22180533_ChIP-Seq_HELA_Human1.87903104
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86827490
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.86488091
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84752236
25VDR_22108803_ChIP-Seq_LS180_Human1.84393273
26TAF15_26573619_Chip-Seq_HEK293_Human1.81559477
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78815552
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74969632
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69844236
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.68990491
31GATA1_26923725_Chip-Seq_HPCs_Mouse1.64772183
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64463244
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.64047115
34IRF1_19129219_ChIP-ChIP_H3396_Human1.63545346
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60469767
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56582362
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.54784430
38HTT_18923047_ChIP-ChIP_STHdh_Human1.52540861
39STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.51772382
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.51471747
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51345274
42SMAD4_21799915_ChIP-Seq_A2780_Human1.51192821
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48784673
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45465033
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.44593988
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44526782
47AR_21572438_ChIP-Seq_LNCaP_Human1.44284098
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42893950
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42893950
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41125421
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39301945
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.37738727
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37518018
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36899034
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36899034
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33582707
57TCF4_22108803_ChIP-Seq_LS180_Human1.32784099
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30248584
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29107288
60AR_25329375_ChIP-Seq_VCAP_Human1.27809265
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27437786
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26867862
63BCAT_22108803_ChIP-Seq_LS180_Human1.26853579
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26376348
65CBP_20019798_ChIP-Seq_JUKART_Human1.26326589
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26326589
67ER_23166858_ChIP-Seq_MCF-7_Human1.24587517
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24550814
69TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.23042368
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21035350
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.20742486
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20615967
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.20590651
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20284642
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19920103
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19727453
77RUNX2_22187159_ChIP-Seq_PCA_Human1.19025948
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.19014145
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18644376
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18494950
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17942268
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15798674
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15602029
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.15135239
85GABP_17652178_ChIP-ChIP_JURKAT_Human1.15005618
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14774696
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.14383045
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.13367902
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12722807
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12019611
91SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11842701
92REST_21632747_ChIP-Seq_MESCs_Mouse1.11681502
93EED_16625203_ChIP-ChIP_MESCs_Mouse1.11473714
94RUNX1_27457419_Chip-Seq_LIVER_Mouse1.10231868
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09860715
96TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09341692
97STAT3_23295773_ChIP-Seq_U87_Human1.09238233
98TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09023677
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.08049819
100AR_21909140_ChIP-Seq_LNCAP_Human1.07609584
101IGF1R_20145208_ChIP-Seq_DFB_Human1.07316155
102POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07067367
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.07055778
104EST1_17652178_ChIP-ChIP_JURKAT_Human1.06465973
105P300_19829295_ChIP-Seq_ESCs_Human1.06168981
106SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06111341
107POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05940081
108P300_18555785_Chip-Seq_ESCs_Mouse1.05813165
109NANOG_16153702_ChIP-ChIP_HESCs_Human1.05258968
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04237611
111MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04049593
112TCF4_23295773_ChIP-Seq_U87_Human1.03831358
113PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02389300
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01577496
115ELK1_19687146_ChIP-ChIP_HELA_Human1.01540009
116FOXM1_23109430_ChIP-Seq_U2OS_Human1.01396928
117SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01287898
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01213324
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01159091
120SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00896009
121CDX2_22108803_ChIP-Seq_LS180_Human1.00846690
122STAT3_18555785_Chip-Seq_ESCs_Mouse1.00268363
123MYC_18940864_ChIP-ChIP_HL60_Human1.00169405
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.99914327
125SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99876867
126TBL1_22424771_ChIP-Seq_293T_Human0.99438681
127CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99397172
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99204031
129NANOG_19829295_ChIP-Seq_ESCs_Human0.98894861
130SOX2_19829295_ChIP-Seq_ESCs_Human0.98894861
131Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98602603
132KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98496590
133EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98327777
134RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98327777
135EOMES_21245162_ChIP-Seq_HESCs_Human0.97788346
136EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97750163
137EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95975129
138PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95733600
139KLF4_18555785_Chip-Seq_ESCs_Mouse0.95604439
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95589782
141NANOG_18555785_Chip-Seq_ESCs_Mouse0.94890761
142SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94555097
143* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94377383
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94247783
145ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93296062
146FOXA2_19822575_ChIP-Seq_HepG2_Human0.92623558
147ARNT_22903824_ChIP-Seq_MCF-7_Human0.92278798
148OCT4_18555785_Chip-Seq_ESCs_Mouse0.90952303
149UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90836565
150RNF2_27304074_Chip-Seq_NSC_Mouse0.90355871
151NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90009929
152NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89496064
153E2F1_18555785_Chip-Seq_ESCs_Mouse0.89333808
154RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88145157
155JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87595793
156TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87292129
157SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87072353
158EZH2_27294783_Chip-Seq_ESCs_Mouse0.86954012
159PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86464597
160PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85739854
161P53_22387025_ChIP-Seq_ESCs_Mouse0.85581239
162AHR_22903824_ChIP-Seq_MCF-7_Human0.85447648
163CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85071155

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.42612009
2MP0002139_abnormal_hepatobiliary_system4.32163427
3MP0003806_abnormal_nucleotide_metabolis4.27328105
4MP0005360_urolithiasis3.74472640
5MP0005085_abnormal_gallbladder_physiolo3.24560385
6MP0003690_abnormal_glial_cell3.17240522
7MP0008875_abnormal_xenobiotic_pharmacok3.09561726
8MP0004381_abnormal_hair_follicle2.94293996
9MP0005365_abnormal_bile_salt2.87930637
10MP0003136_yellow_coat_color2.77555411
11MP0003195_calcinosis2.75115778
12MP0003011_delayed_dark_adaptation2.65583078
13MP0003941_abnormal_skin_development2.61886896
14MP0003950_abnormal_plasma_membrane2.54297448
15MP0009840_abnormal_foam_cell2.33646674
16MP0005083_abnormal_biliary_tract2.26510290
17MP0002736_abnormal_nociception_after2.18407539
18MP0008789_abnormal_olfactory_epithelium2.16752222
19MP0001293_anophthalmia2.05208831
20MP0004742_abnormal_vestibular_system1.87864068
21MP0010678_abnormal_skin_adnexa1.85402128
22MP0003329_amyloid_beta_deposits1.84033358
23MP0000383_abnormal_hair_follicle1.83936425
24MP0006082_CNS_inflammation1.82230284
25MP0003252_abnormal_bile_duct1.81976403
26MP0005451_abnormal_body_composition1.80353414
27MP0003693_abnormal_embryo_hatching1.80187829
28MP0001666_abnormal_nutrient_absorption1.79695221
29MP0002102_abnormal_ear_morphology1.75108443
30MP0002938_white_spotting1.74284223
31MP0008058_abnormal_DNA_repair1.73595694
32MP0000566_synostosis1.72437902
33MP0003890_abnormal_embryonic-extraembry1.65226850
34MP0004142_abnormal_muscle_tone1.64219670
35MP0001529_abnormal_vocalization1.63937483
36MP0001905_abnormal_dopamine_level1.62724032
37MP0000647_abnormal_sebaceous_gland1.59143826
38MP0002118_abnormal_lipid_homeostasis1.55535745
39MP0005332_abnormal_amino_acid1.55396406
40MP0005075_abnormal_melanosome_morpholog1.54875370
41MP0003787_abnormal_imprinting1.54619801
42MP0005409_darkened_coat_color1.53848699
43MP0002254_reproductive_system_inflammat1.53115126
44MP0003186_abnormal_redox_activity1.52796533
45MP0000537_abnormal_urethra_morphology1.51847948
46MP0001485_abnormal_pinna_reflex1.49376977
47MP0003632_abnormal_nervous_system1.45369456
48MP0003634_abnormal_glial_cell1.45071415
49MP0001486_abnormal_startle_reflex1.44568001
50MP0002233_abnormal_nose_morphology1.44190207
51MP0008877_abnormal_DNA_methylation1.43621872
52MP0000049_abnormal_middle_ear1.43573858
53MP0006072_abnormal_retinal_apoptosis1.43143036
54MP0010329_abnormal_lipoprotein_level1.42675288
55MP0000604_amyloidosis1.42293385
56MP0004019_abnormal_vitamin_homeostasis1.41057634
57MP0001968_abnormal_touch/_nociception1.40764116
58MP0003878_abnormal_ear_physiology1.35273243
59MP0005377_hearing/vestibular/ear_phenot1.35273243
60MP0010094_abnormal_chromosome_stability1.34707184
61MP0005410_abnormal_fertilization1.34358591
62MP0004885_abnormal_endolymph1.33277667
63MP0004957_abnormal_blastocyst_morpholog1.30926931
64MP0005171_absent_coat_pigmentation1.28032005
65MP0005367_renal/urinary_system_phenotyp1.27867260
66MP0000516_abnormal_urinary_system1.27867260
67MP0005248_abnormal_Harderian_gland1.27459873
68MP0003119_abnormal_digestive_system1.25882022
69MP0002229_neurodegeneration1.24953635
70MP0010030_abnormal_orbit_morphology1.24704593
71MP0001764_abnormal_homeostasis1.23883027
72MP0004134_abnormal_chest_morphology1.23370647
73MP0004043_abnormal_pH_regulation1.22852975
74MP0000631_abnormal_neuroendocrine_gland1.20320599
75MP0008932_abnormal_embryonic_tissue1.19511030
76MP0003938_abnormal_ear_development1.19293091
77MP0000427_abnormal_hair_cycle1.18428219
78MP0005584_abnormal_enzyme/coenzyme_acti1.17564059
79MP0002697_abnormal_eye_size1.17144654
80MP0002272_abnormal_nervous_system1.16206334
81MP0009745_abnormal_behavioral_response1.15925132
82MP0001501_abnormal_sleep_pattern1.15368843
83MP0003656_abnormal_erythrocyte_physiolo1.13333640
84MP0008260_abnormal_autophagy1.09922907
85MP0002234_abnormal_pharynx_morphology1.09742090
86MP0004133_heterotaxia1.09507718
87MP0005391_vision/eye_phenotype1.09280555
88MP0003755_abnormal_palate_morphology1.07645654
89MP0009765_abnormal_xenobiotic_induced1.07561429
90MP0005646_abnormal_pituitary_gland1.06902238
91MP0005408_hypopigmentation1.06067052
92MP0006276_abnormal_autonomic_nervous1.04826340
93MP0000762_abnormal_tongue_morphology1.04426930
94MP0001286_abnormal_eye_development1.04122703
95MP0002734_abnormal_mechanical_nocicepti1.03653118
96MP0003631_nervous_system_phenotype1.02570517
97MP0002295_abnormal_pulmonary_circulatio1.02388749
98MP0000778_abnormal_nervous_system1.01240555
99MP0000462_abnormal_digestive_system1.00780706
100MP0005551_abnormal_eye_electrophysiolog1.00777133
101MP0002557_abnormal_social/conspecific_i0.99614922
102MP0002098_abnormal_vibrissa_morphology0.99475379
103MP0003191_abnormal_cellular_cholesterol0.99329965
104MP0003880_abnormal_central_pattern0.99264027
105MP0002751_abnormal_autonomic_nervous0.97735333
106MP0002572_abnormal_emotion/affect_behav0.96546078
107MP0003635_abnormal_synaptic_transmissio0.94196814
108MP0003861_abnormal_nervous_system0.93880882
109MP0003633_abnormal_nervous_system0.93245311
110MP0001188_hyperpigmentation0.91673665
111MP0004147_increased_porphyrin_level0.88167978
112MP0005058_abnormal_lysosome_morphology0.87361695
113MP0002063_abnormal_learning/memory/cond0.87221085
114MP0002653_abnormal_ependyma_morphology0.86736119
115MP0005195_abnormal_posterior_eye0.86702134
116MP0002277_abnormal_respiratory_mucosa0.86502937
117MP0002152_abnormal_brain_morphology0.85365046
118MP0003567_abnormal_fetal_cardiomyocyte0.85328794
119MP0003121_genomic_imprinting0.84423239
120MP0004270_analgesia0.83735450
121MP0004782_abnormal_surfactant_physiolog0.83652060
122MP0000609_abnormal_liver_physiology0.83146280
123MP0009379_abnormal_foot_pigmentation0.83000643
124MP0001177_atelectasis0.82598844
125MP0001661_extended_life_span0.81317744
126MP0002111_abnormal_tail_morphology0.80573045
127MP0003868_abnormal_feces_composition0.79963222
128MP0002796_impaired_skin_barrier0.77625248
129MP0004264_abnormal_extraembryonic_tissu0.77029890
130MP0000467_abnormal_esophagus_morphology0.76656136
131MP0001963_abnormal_hearing_physiology0.76014001
132MP0002095_abnormal_skin_pigmentation0.75570072
133MP0005647_abnormal_sex_gland0.74038613
134MP0000579_abnormal_nail_morphology0.72737863
135MP0002090_abnormal_vision0.72341826
136MP0002752_abnormal_somatic_nervous0.71111584
137MP0003718_maternal_effect0.71008507
138MP0002132_abnormal_respiratory_system0.69038063
139MP0000372_irregular_coat_pigmentation0.68989903
140MP0001851_eye_inflammation0.67099531
141MP0002064_seizures0.66969785
142MP0003453_abnormal_keratinocyte_physiol0.66653176
143MP0000377_abnormal_hair_follicle0.66513430
144MP0009643_abnormal_urine_homeostasis0.65826109
145MP0003937_abnormal_limbs/digits/tail_de0.65823655
146MP0005394_taste/olfaction_phenotype0.65098599
147MP0005499_abnormal_olfactory_system0.65098599
148MP0006292_abnormal_olfactory_placode0.64142749
149MP0002138_abnormal_hepatobiliary_system0.64070929
150MP0005253_abnormal_eye_physiology0.64005878
151MP0001346_abnormal_lacrimal_gland0.63512039
152MP0002092_abnormal_eye_morphology0.63127017
153MP0001984_abnormal_olfaction0.61010795
154MP0000026_abnormal_inner_ear0.59671607

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.57146579
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.57146579
3Parakeratosis (HP:0001036)5.03945062
4Neurofibrillary tangles (HP:0002185)4.93992523
5Abnormality of the corticospinal tract (HP:0002492)4.61120087
6Intrahepatic cholestasis (HP:0001406)4.43881272
7Abnormality of the labia minora (HP:0012880)4.24197345
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.13061970
9Increased serum pyruvate (HP:0003542)3.64667965
10Abnormality of glycolysis (HP:0004366)3.64667965
11Sensory axonal neuropathy (HP:0003390)3.58071390
12Xanthomatosis (HP:0000991)3.57254581
13Hyperlipoproteinemia (HP:0010980)3.55200777
14Abnormality of methionine metabolism (HP:0010901)3.24464917
15Cerebral inclusion bodies (HP:0100314)3.22214704
16Prolonged partial thromboplastin time (HP:0003645)3.19960090
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.13285764
18Insidious onset (HP:0003587)3.13203601
19Termporal pattern (HP:0011008)3.13203601
20Onion bulb formation (HP:0003383)3.05632674
21Peripheral hypomyelination (HP:0007182)3.02550796
22Hepatoblastoma (HP:0002884)2.98923654
23Deep venous thrombosis (HP:0002625)2.98740545
24Congenital ichthyosiform erythroderma (HP:0007431)2.97439815
25Hyperglycinuria (HP:0003108)2.95630705
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.94353449
27Hypophosphatemic rickets (HP:0004912)2.94060898
28Anomalous pulmonary venous return (HP:0010772)2.91704503
29Hypochromic microcytic anemia (HP:0004840)2.75649162
30Methylmalonic acidemia (HP:0002912)2.69560861
31Segmental peripheral demyelination/remyelination (HP:0003481)2.68372623
32Partial duplication of thumb phalanx (HP:0009944)2.64843511
33Agnosia (HP:0010524)2.64383905
34Amyloidosis (HP:0011034)2.61392187
35Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.59575467
36Abnormal auditory evoked potentials (HP:0006958)2.57756987
37Intestinal atresia (HP:0011100)2.56806451
38Colon cancer (HP:0003003)2.55969005
39Abnormality of glycine metabolism (HP:0010895)2.55339022
40Abnormality of serine family amino acid metabolism (HP:0010894)2.55339022
41Abnormality of monocarboxylic acid metabolism (HP:0010996)2.51395807
42Abnormality of the pulmonary veins (HP:0011718)2.50624752
43Megalencephaly (HP:0001355)2.48938662
44Fat malabsorption (HP:0002630)2.47135552
45True hermaphroditism (HP:0010459)2.45819574
46Epidermoid cyst (HP:0200040)2.45411141
473-Methylglutaconic aciduria (HP:0003535)2.45359651
48Autoamputation (HP:0001218)2.44924241
49Hypoplastic labia majora (HP:0000059)2.44584753
50Oligodactyly (hands) (HP:0001180)2.44535414
51Axonal loss (HP:0003447)2.42073310
52Volvulus (HP:0002580)2.39475355
53Prolonged neonatal jaundice (HP:0006579)2.38152616
54Spastic tetraparesis (HP:0001285)2.37860469
55Conjugated hyperbilirubinemia (HP:0002908)2.37750612
56Spastic gait (HP:0002064)2.36990979
57Intention tremor (HP:0002080)2.35013568
58Labial hypoplasia (HP:0000066)2.33452165
59Gastrointestinal atresia (HP:0002589)2.32778463
60Leukodystrophy (HP:0002415)2.32765082
61Steatorrhea (HP:0002570)2.32508648
62Joint hemorrhage (HP:0005261)2.32271307
63Scanning speech (HP:0002168)2.31479924
64Hepatosplenomegaly (HP:0001433)2.29999138
65Hypobetalipoproteinemia (HP:0003563)2.29809281
66Abnormality of serum amino acid levels (HP:0003112)2.29654848
67Cerebral hemorrhage (HP:0001342)2.29281449
68Bile duct proliferation (HP:0001408)2.28469066
69Abnormal biliary tract physiology (HP:0012439)2.28469066
70Molar tooth sign on MRI (HP:0002419)2.27664683
71Abnormality of midbrain morphology (HP:0002418)2.27664683
72Esophageal atresia (HP:0002032)2.26441027
73Drooling (HP:0002307)2.25704813
74Pancreatic cysts (HP:0001737)2.25573660
75Premature skin wrinkling (HP:0100678)2.25289507
76Rickets (HP:0002748)2.23809037
77Abnormality of sulfur amino acid metabolism (HP:0004339)2.21603792
78Abnormality of the labia majora (HP:0012881)2.18557472
79Hypoplastic female external genitalia (HP:0012815)2.16990908
80Fragile nails (HP:0001808)2.16877340
81Erythroderma (HP:0001019)2.14447171
82Stridor (HP:0010307)2.13959322
83Pancreatic fibrosis (HP:0100732)2.13212494
84Hyperventilation (HP:0002883)2.12351709
85Impulsivity (HP:0100710)2.12088586
86Partial duplication of the phalanx of hand (HP:0009999)2.11057762
87Peripheral demyelination (HP:0011096)2.10974248
88Morphological abnormality of the inner ear (HP:0011390)2.10693098
89Renal hypoplasia (HP:0000089)2.09620138
90Oligodactyly (HP:0012165)2.09212176
91Aplasia/Hypoplasia of the sternum (HP:0006714)2.08646185
92Abnormal lung lobation (HP:0002101)2.08357574
93Complement deficiency (HP:0004431)2.07889074
94Alacrima (HP:0000522)2.07286460
95Abnormality of the vitamin B12 metabolism (HP:0004341)2.06950497
96Neoplasm of the oral cavity (HP:0100649)2.04773758
97Renal Fanconi syndrome (HP:0001994)2.03913742
98Ependymoma (HP:0002888)2.03041033
99Nephronophthisis (HP:0000090)2.02943676
100Cortical dysplasia (HP:0002539)2.02742316
101Patchy hypopigmentation of hair (HP:0011365)2.01741711
102Supranuclear gaze palsy (HP:0000605)2.00252868
103Excessive salivation (HP:0003781)1.99387702
104Stenosis of the external auditory canal (HP:0000402)1.99051907
105Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.98978128
106White forelock (HP:0002211)1.98327471
107Abnormality of cochlea (HP:0000375)1.98187341
108Clumsiness (HP:0002312)1.98112872
109Chronic hepatic failure (HP:0100626)1.97500413
110Abnormality of vitamin metabolism (HP:0100508)1.97358000
111Chorioretinal atrophy (HP:0000533)1.95721038
112Bifid scrotum (HP:0000048)1.95476324
113Abnormality of vitamin B metabolism (HP:0004340)1.95452683
114Absent septum pellucidum (HP:0001331)1.95283991
115Glioma (HP:0009733)1.94259539
116Hyperglycinemia (HP:0002154)1.94244651
117Confusion (HP:0001289)1.93191836
118Hyperammonemia (HP:0001987)1.92971263
119Abolished electroretinogram (ERG) (HP:0000550)1.92309898
120Nasolacrimal duct obstruction (HP:0000579)1.91593105
121Morphological abnormality of the pyramidal tract (HP:0002062)1.90785556
122Hemivertebrae (HP:0002937)1.87338332
123Hypoplastic pelvis (HP:0008839)1.86401079
124Medulloblastoma (HP:0002885)1.85791693
125Retinal dysplasia (HP:0007973)1.85592562
126Palmar hyperkeratosis (HP:0010765)1.84604371
127Abnormality of complement system (HP:0005339)1.83447957
128Slow saccadic eye movements (HP:0000514)1.82662024
129Congenital sensorineural hearing impairment (HP:0008527)1.82544186
130Dysmetria (HP:0001310)1.81371088
131Abnormality of the labia (HP:0000058)1.80053258
132Cutaneous finger syndactyly (HP:0010554)1.79589041
133Cupped ear (HP:0000378)1.79502085
134Loss of speech (HP:0002371)1.79294692
135Spastic paraparesis (HP:0002313)1.79264078
136Pili torti (HP:0003777)1.77765176
137Recurrent corneal erosions (HP:0000495)1.76252660
138Septo-optic dysplasia (HP:0100842)1.76158306
139Increased circulating renin level (HP:0000848)1.75761566
140Optic nerve hypoplasia (HP:0000609)1.75426509
141Genital tract atresia (HP:0001827)1.74979744
142Focal motor seizures (HP:0011153)1.74546934
143Hypomagnesemia (HP:0002917)1.74451139
144Pendular nystagmus (HP:0012043)1.74325583
145Birth length less than 3rd percentile (HP:0003561)1.73001404
146Irritability (HP:0000737)1.72144753
147Hypercholesterolemia (HP:0003124)1.72113586
148Vascular calcification (HP:0004934)1.71958078
149Abnormality of nail color (HP:0100643)1.71823785
150Vaginal atresia (HP:0000148)1.71492050
151Abnormality of renin-angiotensin system (HP:0000847)1.71433890
152Anophthalmia (HP:0000528)1.70555595
153Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70453575
154Sclerocornea (HP:0000647)1.70242631
155Split foot (HP:0001839)1.67642205
156Metabolic alkalosis (HP:0200114)1.66924670
157Paralysis (HP:0003470)1.66834475
158Cerebral hypomyelination (HP:0006808)1.66324114
159Partial agenesis of the corpus callosum (HP:0001338)1.66266732
160Cerebral edema (HP:0002181)1.66148147
161Duplication of thumb phalanx (HP:0009942)1.66116224
162Enlarged kidneys (HP:0000105)1.66102547
163Preaxial hand polydactyly (HP:0001177)1.65999937
164Abnormality of the astrocytes (HP:0100707)1.65498247
165Astrocytoma (HP:0009592)1.65498247
166Methylmalonic aciduria (HP:0012120)1.65250933
167Plantar hyperkeratosis (HP:0007556)1.64942498
168Median cleft lip (HP:0000161)1.62934629
169Postaxial hand polydactyly (HP:0001162)1.62537058
170Abnormality of the renal medulla (HP:0100957)1.62509290
171Facial hemangioma (HP:0000329)1.61616849
172Abnormality of the septum pellucidum (HP:0007375)1.61292853
173Bifid tongue (HP:0010297)1.61080859
174Patellar aplasia (HP:0006443)1.59890773
175Ectopic kidney (HP:0000086)1.59516018
176Broad-based gait (HP:0002136)1.58022504
177Posterior subcapsular cataract (HP:0007787)1.56141387
178Widely spaced teeth (HP:0000687)1.55099405
179Medial flaring of the eyebrow (HP:0010747)1.55041469
180Abnormality of alanine metabolism (HP:0010916)1.52676428
181Hyperalaninemia (HP:0003348)1.52676428
182Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.52676428
183Aplasia/Hypoplasia of the tongue (HP:0010295)1.52645441
184Aplasia/Hypoplasia of the tibia (HP:0005772)1.51929411
185Abnormality of the diencephalon (HP:0010662)1.50698129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.81474473
2EPHB14.64202819
3ACVR1B4.20505969
4PBK3.72961458
5OXSR13.67683451
6MAPKAPK53.17165718
7WNK32.64916815
8PKN12.54857905
9MST42.38813918
10WNK42.28077808
11EPHA42.25165039
12BCR2.20521340
13WNK12.13087587
14MKNK22.05500728
15TESK22.00758767
16TTK1.98363641
17NEK11.92562009
18ZAK1.91488297
19BUB11.88407019
20MARK11.85387618
21CDC71.83589465
22MET1.81048968
23WEE11.78035485
24TRIM281.77896205
25EPHB21.75323075
26GRK11.71392682
27SRPK11.68997759
28CASK1.63937575
29ADRBK21.58586671
30FGFR21.53122762
31FRK1.50566373
32PLK31.49594598
33STK38L1.49000334
34SGK2231.48999492
35SGK4941.48999492
36MAP4K21.47658931
37BCKDK1.44514490
38NUAK11.41279193
39PNCK1.40849776
40GRK51.39333237
41BLK1.36308888
42CLK11.33649178
43PDK21.31080003
44NTRK11.30447125
45BRSK21.29522391
46DYRK21.28259771
47NTRK31.26154751
48MAPK151.25306867
49CSNK1G31.24464298
50PLK41.24316695
51CSF1R1.23502546
52UHMK11.23076033
53PINK11.19563848
54GRK71.16590226
55IRAK21.14418894
56TGFBR11.12881165
57CSNK1A1L1.12495525
58ERBB41.12444793
59MAP3K41.10359991
60PLK11.09524892
61CSNK1G11.04345884
62FGR1.04193229
63TNIK1.02350171
64ROCK21.01082167
65PRKCQ0.99307739
66MARK20.99093950
67TSSK60.99063595
68MINK10.98834219
69IRAK10.97550020
70MAP3K140.97401700
71CAMK2B0.96055009
72MAP2K20.92949670
73MAPK70.92507735
74NTRK20.90763185
75CSK0.90656406
76GSK3A0.89341815
77ERBB30.86383384
78NME10.84731954
79PLK20.81328888
80VRK10.81300107
81PRPF4B0.79860950
82NEK60.79646418
83PIK3CA0.79301569
84YES10.79233957
85GRK60.77797962
86EIF2AK30.77195218
87CAMK2D0.77073027
88TYRO30.74232391
89STK30.74141027
90IRAK40.74139978
91CSNK1G20.72805646
92MKNK10.72415268
93CAMK2G0.71396017
94PRKCG0.70121980
95INSRR0.67929611
96CDK190.67781599
97SIK10.67696294
98NEK20.66287120
99RPS6KA50.66023445
100LIMK10.64653516
101ATR0.64580155
102MST1R0.64303552
103AURKB0.63307467
104PRKD10.63130636
105PAK30.60543130
106PRKCE0.59908422
107ERN10.58029839
108SGK20.57373618
109CDK120.57009769
110RPS6KA40.55898238
111STK100.55578103
112DAPK20.53725832
113CHEK20.53564629
114STK160.53068173
115EPHA30.52931618
116PHKG20.51961570
117PHKG10.51961570
118CAMK2A0.51781330
119DYRK1A0.48709500
120DYRK30.48383244
121MUSK0.48141213
122ATM0.44469915
123EIF2AK20.44232888
124EPHA20.44125035
125PRKCZ0.43276116
126INSR0.43268063
127BMPR1B0.42715235
128BMPR20.42661846
129EIF2AK10.42316441
130PRKACB0.42281927
131ERBB20.41032726
132ADRBK10.40620357
133FGFR10.40299166
134PRKACA0.40289181
135TAF10.39866472
136IKBKB0.38571231
137MAPK130.38017814
138FYN0.37806103
139BRSK10.36888073
140PRKG10.36602844
141CDK140.36209061
142CDK180.36102121
143CSNK1A10.36005015
144MOS0.35209227
145CSNK1E0.35163719
146SGK10.34825106
147ABL20.34174841
148PRKCD0.33757503
149CSNK1D0.33025139
150HIPK20.30970094
151PRKG20.30666283
152ICK0.29734071
153CDK30.29136998
154ABL10.28990743
155MAPK40.26517877
156PRKACG0.26042001
157NLK0.24981398
158FGFR40.24523092
159MAPK120.24074291
160MATK0.24071101
161IGF1R0.23885443

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.71158599
2Fatty acid elongation_Homo sapiens_hsa000624.32486971
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.25175718
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.54180396
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.49988911
6Histidine metabolism_Homo sapiens_hsa003402.69850643
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.65217581
8Ether lipid metabolism_Homo sapiens_hsa005652.35480362
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.28036571
10Vitamin B6 metabolism_Homo sapiens_hsa007502.22230383
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.17665925
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16363878
13Butanoate metabolism_Homo sapiens_hsa006502.16264797
14Sulfur metabolism_Homo sapiens_hsa009202.12782752
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.10271287
16Mismatch repair_Homo sapiens_hsa034302.09275653
17Homologous recombination_Homo sapiens_hsa034402.07237718
18Non-homologous end-joining_Homo sapiens_hsa034502.06934007
19Nitrogen metabolism_Homo sapiens_hsa009101.88512049
20Fanconi anemia pathway_Homo sapiens_hsa034601.84019301
21Peroxisome_Homo sapiens_hsa041461.81589569
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81483032
23Chemical carcinogenesis_Homo sapiens_hsa052041.79733993
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.78340049
25Fatty acid metabolism_Homo sapiens_hsa012121.71205703
26Nicotine addiction_Homo sapiens_hsa050331.69134483
27Tryptophan metabolism_Homo sapiens_hsa003801.65003165
28Complement and coagulation cascades_Homo sapiens_hsa046101.61695461
29Propanoate metabolism_Homo sapiens_hsa006401.61393660
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.61188458
31Linoleic acid metabolism_Homo sapiens_hsa005911.60546086
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58761783
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56975300
34Retinol metabolism_Homo sapiens_hsa008301.55530774
35Phototransduction_Homo sapiens_hsa047441.52177464
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38292154
37beta-Alanine metabolism_Homo sapiens_hsa004101.36810342
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35020786
39Fatty acid degradation_Homo sapiens_hsa000711.34778400
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34727316
41Basal transcription factors_Homo sapiens_hsa030221.31425017
42Arginine and proline metabolism_Homo sapiens_hsa003301.26596234
43Vitamin digestion and absorption_Homo sapiens_hsa049771.19809206
44Tyrosine metabolism_Homo sapiens_hsa003501.15699804
45DNA replication_Homo sapiens_hsa030301.14248380
46RNA degradation_Homo sapiens_hsa030181.13953312
47Arginine biosynthesis_Homo sapiens_hsa002201.13493253
48Staphylococcus aureus infection_Homo sapiens_hsa051501.11497168
49Proteasome_Homo sapiens_hsa030501.10032624
50Arachidonic acid metabolism_Homo sapiens_hsa005901.08394575
51PPAR signaling pathway_Homo sapiens_hsa033201.07840711
52RNA polymerase_Homo sapiens_hsa030201.05293337
53Glutathione metabolism_Homo sapiens_hsa004801.01510843
54Cell cycle_Homo sapiens_hsa041100.99490483
55Sphingolipid metabolism_Homo sapiens_hsa006000.99189800
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98538128
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96195004
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95503853
59Protein digestion and absorption_Homo sapiens_hsa049740.92903278
60Folate biosynthesis_Homo sapiens_hsa007900.91429156
61Fat digestion and absorption_Homo sapiens_hsa049750.91177067
62ABC transporters_Homo sapiens_hsa020100.90797603
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90590564
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86975123
65Phenylalanine metabolism_Homo sapiens_hsa003600.86344806
66Basal cell carcinoma_Homo sapiens_hsa052170.85195546
67Hedgehog signaling pathway_Homo sapiens_hsa043400.84186216
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83291422
69Renin-angiotensin system_Homo sapiens_hsa046140.80503729
70Pyruvate metabolism_Homo sapiens_hsa006200.80277661
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75048300
72Huntingtons disease_Homo sapiens_hsa050160.74963833
73Spliceosome_Homo sapiens_hsa030400.73260620
74Bile secretion_Homo sapiens_hsa049760.70706165
75Oocyte meiosis_Homo sapiens_hsa041140.67949949
76RNA transport_Homo sapiens_hsa030130.66626803
77Oxidative phosphorylation_Homo sapiens_hsa001900.65653114
78Protein export_Homo sapiens_hsa030600.63794683
79Fatty acid biosynthesis_Homo sapiens_hsa000610.63755382
80Metabolic pathways_Homo sapiens_hsa011000.63395913
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61809810
82One carbon pool by folate_Homo sapiens_hsa006700.60459233
83Base excision repair_Homo sapiens_hsa034100.60331113
84Glycerolipid metabolism_Homo sapiens_hsa005610.59372327
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.58500857
86Hippo signaling pathway_Homo sapiens_hsa043900.57401522
87p53 signaling pathway_Homo sapiens_hsa041150.55758896
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55150762
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54442395
90Purine metabolism_Homo sapiens_hsa002300.53571935
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52854534
92GABAergic synapse_Homo sapiens_hsa047270.51823379
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51256185
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.49558227
95Taste transduction_Homo sapiens_hsa047420.49438750
96Ovarian steroidogenesis_Homo sapiens_hsa049130.49296297
97Nucleotide excision repair_Homo sapiens_hsa034200.48830204
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47812476
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46620959
100Morphine addiction_Homo sapiens_hsa050320.46191330
101Caffeine metabolism_Homo sapiens_hsa002320.44447262
102Selenocompound metabolism_Homo sapiens_hsa004500.43454659
103Mineral absorption_Homo sapiens_hsa049780.42882138
104Starch and sucrose metabolism_Homo sapiens_hsa005000.42664456
105Glutamatergic synapse_Homo sapiens_hsa047240.42490816
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39750206
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.38881093
108Axon guidance_Homo sapiens_hsa043600.36965131
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32819099
110Alzheimers disease_Homo sapiens_hsa050100.31883666
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30675740
112Prion diseases_Homo sapiens_hsa050200.30127559
113Lysosome_Homo sapiens_hsa041420.29509693
114Autoimmune thyroid disease_Homo sapiens_hsa053200.29154543
115Parkinsons disease_Homo sapiens_hsa050120.27017289
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.26039521
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.25442941
118Serotonergic synapse_Homo sapiens_hsa047260.24365778
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.21131297
120Phagosome_Homo sapiens_hsa041450.20896790
121African trypanosomiasis_Homo sapiens_hsa051430.19714675
122Rheumatoid arthritis_Homo sapiens_hsa053230.16930191
123Carbon metabolism_Homo sapiens_hsa012000.12839762
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12015344
125Ras signaling pathway_Homo sapiens_hsa040140.10762876
126Tight junction_Homo sapiens_hsa045300.10306987
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.09259763
128Collecting duct acid secretion_Homo sapiens_hsa049660.09226921
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.08616453
130Pentose phosphate pathway_Homo sapiens_hsa000300.08290528
131Sulfur relay system_Homo sapiens_hsa041220.08222211
132Biosynthesis of amino acids_Homo sapiens_hsa012300.08123618
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.07765898
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06760660
135Malaria_Homo sapiens_hsa051440.06600437
136Renal cell carcinoma_Homo sapiens_hsa052110.06472848
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.06224977
138Regulation of autophagy_Homo sapiens_hsa041400.04808325

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