MOB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.98269434
2ATP synthesis coupled proton transport (GO:0015986)4.83128755
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.83128755
4protein neddylation (GO:0045116)4.73833087
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.58051131
6chaperone-mediated protein transport (GO:0072321)4.12707517
7DNA double-strand break processing (GO:0000729)3.96256997
8neuron cell-cell adhesion (GO:0007158)3.78071742
9chromatin remodeling at centromere (GO:0031055)3.70572168
10respiratory electron transport chain (GO:0022904)3.70547274
11CENP-A containing nucleosome assembly (GO:0034080)3.68568881
12protein complex biogenesis (GO:0070271)3.66681512
13electron transport chain (GO:0022900)3.62702352
14cullin deneddylation (GO:0010388)3.60754651
15DNA damage response, detection of DNA damage (GO:0042769)3.50297037
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39835407
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.39835407
18NADH dehydrogenase complex assembly (GO:0010257)3.39835407
19postsynaptic membrane organization (GO:0001941)3.39324298
20keratinocyte development (GO:0003334)3.35401032
21presynaptic membrane assembly (GO:0097105)3.35192036
22organelle disassembly (GO:1903008)3.34749824
23pyrimidine nucleobase catabolic process (GO:0006208)3.25655594
24GTP biosynthetic process (GO:0006183)3.25290799
25regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24265159
26regulation of mitotic spindle checkpoint (GO:1903504)3.24265159
27protein deneddylation (GO:0000338)3.22012883
28positive regulation of protein homodimerization activity (GO:0090073)3.17971300
29proteasome assembly (GO:0043248)3.16166173
30histone exchange (GO:0043486)3.16056664
31nonmotile primary cilium assembly (GO:0035058)3.14327053
32establishment of integrated proviral latency (GO:0075713)3.13730409
33mitochondrial respiratory chain complex assembly (GO:0033108)3.13270242
34positive regulation of synapse assembly (GO:0051965)3.11038206
35sympathetic nervous system development (GO:0048485)3.07680340
36regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.07361947
37respiratory chain complex IV assembly (GO:0008535)3.05474209
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.03445499
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02952901
40regulation of coenzyme metabolic process (GO:0051196)2.98067284
41regulation of cofactor metabolic process (GO:0051193)2.98067284
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96995584
43dopamine transport (GO:0015872)2.96981847
44presynaptic membrane organization (GO:0097090)2.94401818
45ribonucleoprotein complex disassembly (GO:0032988)2.94122990
46cholesterol biosynthetic process (GO:0006695)2.92972110
47water-soluble vitamin biosynthetic process (GO:0042364)2.92743088
48neuronal action potential propagation (GO:0019227)2.92189911
49protein localization to cilium (GO:0061512)2.91159530
50regulation of acyl-CoA biosynthetic process (GO:0050812)2.88701929
51guanosine-containing compound biosynthetic process (GO:1901070)2.87797247
52sequestering of actin monomers (GO:0042989)2.87348732
53negative regulation of dendrite morphogenesis (GO:0050774)2.87255757
54cytochrome complex assembly (GO:0017004)2.85425728
557-methylguanosine mRNA capping (GO:0006370)2.84990124
56RNA capping (GO:0036260)2.83144686
577-methylguanosine RNA capping (GO:0009452)2.83144686
58sterol biosynthetic process (GO:0016126)2.78764807
59DNA replication-independent nucleosome assembly (GO:0006336)2.78594621
60DNA replication-independent nucleosome organization (GO:0034724)2.78594621
61viral protein processing (GO:0019082)2.77722189
62protein localization to synapse (GO:0035418)2.74877740
63long-chain fatty acid biosynthetic process (GO:0042759)2.72955487
64regulation of meiosis I (GO:0060631)2.67175217
65dopamine biosynthetic process (GO:0042416)2.65457746
66negative regulation of synaptic transmission, GABAergic (GO:0032229)2.64927656
67short-term memory (GO:0007614)2.64099351
68negative regulation of DNA-dependent DNA replication (GO:2000104)2.63917405
69transferrin transport (GO:0033572)2.63664763
70histone mRNA metabolic process (GO:0008334)2.62734071
71protein-cofactor linkage (GO:0018065)2.62017687
72regulation of helicase activity (GO:0051095)2.61272136
73tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60787239
74RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60787239
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.60615225
76ATP hydrolysis coupled proton transport (GO:0015991)2.60514708
77energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.60514708
78regulation of synapse assembly (GO:0051963)2.59965047
79startle response (GO:0001964)2.59859064
80protein K11-linked ubiquitination (GO:0070979)2.59119569
81behavioral response to nicotine (GO:0035095)2.59096308
82regulation of sulfur metabolic process (GO:0042762)2.57742438
83vocalization behavior (GO:0071625)2.56720835
84ubiquinone metabolic process (GO:0006743)2.54654708
85negative regulation of DNA recombination (GO:0045910)2.53604671
86nucleobase catabolic process (GO:0046113)2.52317610
87synaptic vesicle exocytosis (GO:0016079)2.51331059
88positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.50371764
89hydrogen ion transmembrane transport (GO:1902600)2.50040650
90IMP biosynthetic process (GO:0006188)2.50006955
91peptidyl-histidine modification (GO:0018202)2.48173217
92regulation of cellular amino acid metabolic process (GO:0006521)2.47919764
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.47355129
94regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.47007776
95intraciliary transport (GO:0042073)2.46400802
96purine nucleobase biosynthetic process (GO:0009113)2.45989457
97histone H2A acetylation (GO:0043968)2.45024380
98protein localization to mitochondrion (GO:0070585)2.44992909
99regulation of vesicle fusion (GO:0031338)2.44439439
100establishment of viral latency (GO:0019043)2.43803258
101termination of RNA polymerase III transcription (GO:0006386)2.43713889
102transcription elongation from RNA polymerase III promoter (GO:0006385)2.43713889
103trivalent inorganic cation transport (GO:0072512)2.43385014
104ferric iron transport (GO:0015682)2.43385014
105positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.43013878
106gamma-aminobutyric acid signaling pathway (GO:0007214)2.42745253
107dendrite development (GO:0016358)2.41910863
108negative regulation of execution phase of apoptosis (GO:1900118)2.41759459
109UTP biosynthetic process (GO:0006228)2.40974859
110response to pheromone (GO:0019236)2.40219081
111DNA ligation (GO:0006266)2.39368290
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.38696858
113DNA replication-dependent nucleosome organization (GO:0034723)2.38140618
114DNA replication-dependent nucleosome assembly (GO:0006335)2.38140618
115L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.37810898
116intracellular protein transmembrane import (GO:0044743)2.36089099
117neuron recognition (GO:0008038)2.35518819
118positive regulation of mitochondrial fission (GO:0090141)2.35443947
119DNA catabolic process, exonucleolytic (GO:0000738)2.33319340
120limb bud formation (GO:0060174)2.33202751
121glutamate receptor signaling pathway (GO:0007215)2.32648749
122negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.32234644
123negative regulation of ligase activity (GO:0051352)2.32234644
124proton transport (GO:0015992)2.31790736
125neuron fate determination (GO:0048664)2.31679838
126spindle checkpoint (GO:0031577)2.31024685
127negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.30904877
128mitotic metaphase plate congression (GO:0007080)2.30575560
129inner mitochondrial membrane organization (GO:0007007)2.30361252
130G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.30344678
131single strand break repair (GO:0000012)2.29604444
132negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.29575378
133negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.29575378
134negative regulation of mitotic sister chromatid segregation (GO:0033048)2.29575378
135negative regulation of mitotic sister chromatid separation (GO:2000816)2.29575378
136negative regulation of sister chromatid segregation (GO:0033046)2.29575378
137serotonin receptor signaling pathway (GO:0007210)2.29558760
138spliceosomal snRNP assembly (GO:0000387)2.29163606
139estrogen biosynthetic process (GO:0006703)2.28950572
140regulation of development, heterochronic (GO:0040034)2.27923566
141mitotic spindle checkpoint (GO:0071174)2.27161194
142neural tube formation (GO:0001841)2.26972054
143positive regulation of cellular response to oxidative stress (GO:1900409)2.26723144
144positive regulation of response to oxidative stress (GO:1902884)2.26723144
145purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.25852029
146calcium-mediated signaling using intracellular calcium source (GO:0035584)2.25633145
147nucleoside diphosphate phosphorylation (GO:0006165)2.25584711
148hydrogen transport (GO:0006818)2.24793968
149GMP metabolic process (GO:0046037)2.24779120
150IMP metabolic process (GO:0046040)2.24451701
151cell fate commitment involved in formation of primary germ layer (GO:0060795)2.24177992
152regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.23641439
153regulation of pigment cell differentiation (GO:0050932)2.23222283
154establishment of melanosome localization (GO:0032401)2.23195941
155opioid receptor signaling pathway (GO:0038003)2.23103383
156protein targeting to mitochondrion (GO:0006626)2.22970062
157cerebral cortex radially oriented cell migration (GO:0021799)2.22297215
158neuron-neuron synaptic transmission (GO:0007270)2.20168335
159regulation of mitochondrial translation (GO:0070129)2.19730769
160melanosome transport (GO:0032402)2.19260173
161regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.18955558
162catecholamine transport (GO:0051937)2.18440780
163negative regulation of homotypic cell-cell adhesion (GO:0034111)2.18424265
164establishment of protein localization to mitochondrion (GO:0072655)2.18029559
165phagosome maturation (GO:0090382)2.17896722
166neurofilament cytoskeleton organization (GO:0060052)2.17675535
167purine nucleoside triphosphate biosynthetic process (GO:0009145)2.17654462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.72421213
2EZH2_22144423_ChIP-Seq_EOC_Human3.02790022
3TAF15_26573619_Chip-Seq_HEK293_Human2.89018413
4BMI1_23680149_ChIP-Seq_NPCS_Mouse2.78491001
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.73144749
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.58647078
7VDR_22108803_ChIP-Seq_LS180_Human2.56154343
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46169216
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.31269854
10FUS_26573619_Chip-Seq_HEK293_Human2.25402466
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.22137129
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18565704
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16174999
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.14815714
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12312951
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.12210297
17P300_19829295_ChIP-Seq_ESCs_Human2.10400382
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08295196
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05003483
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.00141217
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00062420
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97505664
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94344032
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.94233168
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94152779
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93543989
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92520176
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91787890
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89109696
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85446466
31RNF2_27304074_Chip-Seq_NSC_Mouse1.85075634
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84882216
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82125922
34IGF1R_20145208_ChIP-Seq_DFB_Human1.81022210
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.80735911
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79589355
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73449716
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70818340
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69903120
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68848510
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66965556
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.66413429
43VDR_23849224_ChIP-Seq_CD4+_Human1.65154306
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62821481
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61852796
46EWS_26573619_Chip-Seq_HEK293_Human1.61793184
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58638584
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.56389347
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.55890261
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55600546
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54471892
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53916106
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53916106
54FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.52771731
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.52096824
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51939933
57MYC_18940864_ChIP-ChIP_HL60_Human1.51545769
58ER_23166858_ChIP-Seq_MCF-7_Human1.51426961
59SMAD4_21799915_ChIP-Seq_A2780_Human1.50496516
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.47968275
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47040819
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41880435
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.41434837
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39816032
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37387534
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37024885
67P53_22387025_ChIP-Seq_ESCs_Mouse1.36530755
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35532979
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35078945
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.35019359
71* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33899375
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33306999
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.31647472
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31385111
75SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30268861
76JUN_21703547_ChIP-Seq_K562_Human1.29978477
77ELK1_19687146_ChIP-ChIP_HELA_Human1.29788374
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.28393892
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28200612
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.27436414
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26702748
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.26610953
83REST_21632747_ChIP-Seq_MESCs_Mouse1.25409323
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.25222847
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23235381
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.23033188
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22788603
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.22768924
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22259131
90MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20218194
91CBP_20019798_ChIP-Seq_JUKART_Human1.19905666
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19905666
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19781098
94NANOG_16153702_ChIP-ChIP_HESCs_Human1.19672088
95NMYC_18555785_Chip-Seq_ESCs_Mouse1.19219489
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19146567
97SOX2_16153702_ChIP-ChIP_HESCs_Human1.19118028
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.19098694
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18153515
100P300_18555785_Chip-Seq_ESCs_Mouse1.18135552
101MYC_18555785_ChIP-Seq_MESCs_Mouse1.18086742
102PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18079611
103SOX2_18555785_Chip-Seq_ESCs_Mouse1.17992067
104IRF1_19129219_ChIP-ChIP_H3396_Human1.17915549
105AR_25329375_ChIP-Seq_VCAP_Human1.17305752
106CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16703328
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14064527
108FOXP3_21729870_ChIP-Seq_TREG_Human1.13202418
109AR_21572438_ChIP-Seq_LNCaP_Human1.12672037
110TP53_18474530_ChIP-ChIP_U2OS_Human1.11403527
111ZNF274_21170338_ChIP-Seq_K562_Hela1.10477614
112RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09824523
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.07625949
114WT1_19549856_ChIP-ChIP_CCG9911_Human1.06976196
115JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05718864
116KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05176699
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04827684
118RUNX2_22187159_ChIP-Seq_PCA_Human1.04658428
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04185153
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01725291
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01152471
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00759848
123* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00755507
124TP53_22573176_ChIP-Seq_HFKS_Human1.00642731
125KLF4_18555785_Chip-Seq_ESCs_Mouse0.99997619
126PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99764759
127HTT_18923047_ChIP-ChIP_STHdh_Human0.99449321
128SRF_21415370_ChIP-Seq_HL-1_Mouse0.98779314
129NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97198519
130DCP1A_22483619_ChIP-Seq_HELA_Human0.96021799
131SOX2_19829295_ChIP-Seq_ESCs_Human0.95824502
132NANOG_19829295_ChIP-Seq_ESCs_Human0.95824502
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95596666
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95596666
135THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95062748
136TCF4_22108803_ChIP-Seq_LS180_Human0.94771106
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91945600
138CRX_20693478_ChIP-Seq_RETINA_Mouse0.90960980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.15414137
2MP0001188_hyperpigmentation3.41694562
3MP0009379_abnormal_foot_pigmentation2.86092272
4MP0006276_abnormal_autonomic_nervous2.83305316
5MP0008877_abnormal_DNA_methylation2.78556905
6MP0001968_abnormal_touch/_nociception2.54592989
7MP0001529_abnormal_vocalization2.48128166
8MP0010386_abnormal_urinary_bladder2.41796596
9MP0003136_yellow_coat_color2.38411407
10MP0002736_abnormal_nociception_after2.37980659
11MP0008058_abnormal_DNA_repair2.27544955
12MP0004270_analgesia2.22377396
13MP0002735_abnormal_chemical_nociception2.21255605
14MP0002734_abnormal_mechanical_nocicepti2.20156705
15MP0001905_abnormal_dopamine_level2.17420674
16MP0003890_abnormal_embryonic-extraembry2.15121341
17MP0002102_abnormal_ear_morphology2.10192540
18MP0009745_abnormal_behavioral_response2.02474992
19MP0002638_abnormal_pupillary_reflex2.01011409
20MP0001984_abnormal_olfaction2.00142496
21MP0006292_abnormal_olfactory_placode1.98623832
22MP0003635_abnormal_synaptic_transmissio1.96700811
23MP0000372_irregular_coat_pigmentation1.92274267
24MP0003122_maternal_imprinting1.81575770
25MP0005171_absent_coat_pigmentation1.80423940
26MP0002751_abnormal_autonomic_nervous1.79764340
27MP0002572_abnormal_emotion/affect_behav1.78712855
28MP0002277_abnormal_respiratory_mucosa1.77636826
29MP0001293_anophthalmia1.73748045
30MP0002063_abnormal_learning/memory/cond1.73324971
31MP0002272_abnormal_nervous_system1.72388085
32MP0005409_darkened_coat_color1.72313750
33MP0002184_abnormal_innervation1.71600619
34MP0008789_abnormal_olfactory_epithelium1.71152627
35MP0005646_abnormal_pituitary_gland1.70013298
36MP0004859_abnormal_synaptic_plasticity1.67518166
37MP0005187_abnormal_penis_morphology1.65134514
38MP0001986_abnormal_taste_sensitivity1.64253630
39MP0002064_seizures1.64159468
40MP0009046_muscle_twitch1.63114597
41MP0001440_abnormal_grooming_behavior1.62109851
42MP0003567_abnormal_fetal_cardiomyocyte1.60350636
43MP0001501_abnormal_sleep_pattern1.59204023
44MP0004133_heterotaxia1.58879863
45MP0002067_abnormal_sensory_capabilities1.55922142
46MP0002876_abnormal_thyroid_physiology1.55377340
47MP0003787_abnormal_imprinting1.54924537
48MP0008995_early_reproductive_senescence1.54673293
49MP0000778_abnormal_nervous_system1.52369032
50MP0002163_abnormal_gland_morphology1.50942518
51MP0003119_abnormal_digestive_system1.45218546
52MP0010094_abnormal_chromosome_stability1.44852700
53MP0004215_abnormal_myocardial_fiber1.44237613
54MP0003937_abnormal_limbs/digits/tail_de1.44032252
55MP0005645_abnormal_hypothalamus_physiol1.43348170
56MP0000631_abnormal_neuroendocrine_gland1.43086111
57MP0001970_abnormal_pain_threshold1.43077156
58MP0008932_abnormal_embryonic_tissue1.42416740
59MP0000647_abnormal_sebaceous_gland1.40393998
60MP0005423_abnormal_somatic_nervous1.39605831
61MP0003941_abnormal_skin_development1.36421208
62MP0002557_abnormal_social/conspecific_i1.35251905
63MP0005499_abnormal_olfactory_system1.35073454
64MP0005394_taste/olfaction_phenotype1.35073454
65MP0001486_abnormal_startle_reflex1.33519414
66MP0006072_abnormal_retinal_apoptosis1.32800191
67MP0002733_abnormal_thermal_nociception1.32306433
68MP0006035_abnormal_mitochondrial_morpho1.32111209
69MP0003693_abnormal_embryo_hatching1.30337882
70MP0002938_white_spotting1.28913317
71MP0000566_synostosis1.26849410
72MP0003315_abnormal_perineum_morphology1.25779034
73MP0005379_endocrine/exocrine_gland_phen1.24469349
74MP0002837_dystrophic_cardiac_calcinosis1.22891102
75MP0004957_abnormal_blastocyst_morpholog1.21756812
76MP0002233_abnormal_nose_morphology1.19495635
77MP0004142_abnormal_muscle_tone1.17764160
78MP0000026_abnormal_inner_ear1.13790020
79MP0002090_abnormal_vision1.13744189
80MP0003879_abnormal_hair_cell1.13196335
81MP0004381_abnormal_hair_follicle1.12965261
82MP0005084_abnormal_gallbladder_morpholo1.11696101
83MP0001177_atelectasis1.11437976
84MP0009697_abnormal_copulation1.10966183
85MP0001286_abnormal_eye_development1.10725942
86MP0005386_behavior/neurological_phenoty1.09677836
87MP0004924_abnormal_behavior1.09677836
88MP0003221_abnormal_cardiomyocyte_apopto1.09532935
89MP0000015_abnormal_ear_pigmentation1.09003006
90MP0003011_delayed_dark_adaptation1.08910002
91MP0004742_abnormal_vestibular_system1.08740402
92MP0003121_genomic_imprinting1.05602372
93MP0004145_abnormal_muscle_electrophysio1.05166831
94MP0000049_abnormal_middle_ear1.04693513
95MP0001963_abnormal_hearing_physiology1.01871229
96MP0002177_abnormal_outer_ear1.01810024
97MP0002909_abnormal_adrenal_gland1.00792269
98MP0005391_vision/eye_phenotype0.99003355
99MP0003137_abnormal_impulse_conducting0.98390481
100MP0002234_abnormal_pharynx_morphology0.97697058
101MP0009250_abnormal_appendicular_skeleto0.96747383
102MP0003077_abnormal_cell_cycle0.96311387
103MP0005551_abnormal_eye_electrophysiolog0.95780937
104MP0002752_abnormal_somatic_nervous0.94817599
105MP0002210_abnormal_sex_determination0.92763450
106MP0001485_abnormal_pinna_reflex0.92382395
107MP0002882_abnormal_neuron_morphology0.92371423
108MP0003938_abnormal_ear_development0.91214505
109MP0000538_abnormal_urinary_bladder0.91066811
110MP0001299_abnormal_eye_distance/0.90464674
111MP0002697_abnormal_eye_size0.90246435
112MP0008260_abnormal_autophagy0.88342677
113MP0000955_abnormal_spinal_cord0.88295865
114MP0003786_premature_aging0.87966467
115MP0008007_abnormal_cellular_replicative0.87919966
116MP0002009_preneoplasia0.87466004
117MP0005248_abnormal_Harderian_gland0.87170994
118MP0001664_abnormal_digestion0.87078349
119MP0005367_renal/urinary_system_phenotyp0.86936008
120MP0000516_abnormal_urinary_system0.86936008
121MP0006036_abnormal_mitochondrial_physio0.85860957
122MP0000639_abnormal_adrenal_gland0.85854899
123MP0001929_abnormal_gametogenesis0.85331301
124MP0008057_abnormal_DNA_replication0.83949892
125MP0003111_abnormal_nucleus_morphology0.82784117
126MP0000681_abnormal_thyroid_gland0.82743498
127MP0000653_abnormal_sex_gland0.81482836
128MP0005195_abnormal_posterior_eye0.80399805
129MP0006054_spinal_hemorrhage0.80299758
130MP0003861_abnormal_nervous_system0.80003247
131MP0005253_abnormal_eye_physiology0.79943349
132MP0002653_abnormal_ependyma_morphology0.79902202
133MP0001502_abnormal_circadian_rhythm0.79759024
134MP0001919_abnormal_reproductive_system0.73868907
135MP0002822_catalepsy0.73210477
136MP0000013_abnormal_adipose_tissue0.72923698
137MP0002066_abnormal_motor_capabilities/c0.72556719
138MP0002095_abnormal_skin_pigmentation0.71383696
139MP0002282_abnormal_trachea_morphology0.71324737
140MP0003123_paternal_imprinting0.70842495
141MP0003718_maternal_effect0.70100618
142MP0004811_abnormal_neuron_physiology0.68274957
143MP0001542_abnormal_bone_strength0.66826893
144MP0000762_abnormal_tongue_morphology0.66320856
145MP0002160_abnormal_reproductive_system0.65501024
146MP0004782_abnormal_surfactant_physiolog0.64098318
147MP0003755_abnormal_palate_morphology0.61398236

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.87695399
2Hypothermia (HP:0002045)4.60658679
3Abnormal mitochondria in muscle tissue (HP:0008316)4.29466615
4Progressive macrocephaly (HP:0004481)4.19577366
5Mitochondrial inheritance (HP:0001427)4.08693027
6Focal motor seizures (HP:0011153)3.86425438
7Abnormality of the labia minora (HP:0012880)3.77208673
8Increased hepatocellular lipid droplets (HP:0006565)3.76264745
9Acute encephalopathy (HP:0006846)3.37169198
10Increased CSF lactate (HP:0002490)3.36867228
11Renal Fanconi syndrome (HP:0001994)3.32420071
12Atonic seizures (HP:0010819)3.28326041
13Medial flaring of the eyebrow (HP:0010747)3.19519697
14Febrile seizures (HP:0002373)3.08918125
15Gait imbalance (HP:0002141)3.05347659
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.02209988
17Abnormal hair whorl (HP:0010721)3.01028311
18Lipid accumulation in hepatocytes (HP:0006561)3.00888927
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.93813905
20Hepatocellular necrosis (HP:0001404)2.89424762
21Congenital primary aphakia (HP:0007707)2.88973256
22Nephrogenic diabetes insipidus (HP:0009806)2.82867693
23Optic disc pallor (HP:0000543)2.77554984
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.77187349
25Epileptic encephalopathy (HP:0200134)2.67138177
26Methylmalonic acidemia (HP:0002912)2.62065552
27Parakeratosis (HP:0001036)2.60693214
28Septo-optic dysplasia (HP:0100842)2.48870630
29Cortical dysplasia (HP:0002539)2.47896687
30Limb dystonia (HP:0002451)2.45122784
31Hyperventilation (HP:0002883)2.44666663
32Colon cancer (HP:0003003)2.42735325
33Exercise intolerance (HP:0003546)2.41843506
34Genital tract atresia (HP:0001827)2.40786216
35Supernumerary spleens (HP:0009799)2.40524514
36Vaginal atresia (HP:0000148)2.40475757
37Hyperglycinemia (HP:0002154)2.31658854
38Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.28761274
39Absence seizures (HP:0002121)2.27870535
40Abnormality of renal resorption (HP:0011038)2.27616776
413-Methylglutaconic aciduria (HP:0003535)2.27102491
42True hermaphroditism (HP:0010459)2.26732850
43Exertional dyspnea (HP:0002875)2.24428996
44Abnormal lung lobation (HP:0002101)2.22464925
45Intestinal atresia (HP:0011100)2.21798808
46Molar tooth sign on MRI (HP:0002419)2.19364503
47Abnormality of midbrain morphology (HP:0002418)2.19364503
48Aplasia/Hypoplasia of the lens (HP:0008063)2.19092247
49Pancreatic fibrosis (HP:0100732)2.16680019
50Aplasia/hypoplasia of the uterus (HP:0008684)2.16482925
51Exercise-induced muscle cramps (HP:0003710)2.16399507
52Increased intramyocellular lipid droplets (HP:0012240)2.15343206
53Bifid tongue (HP:0010297)2.14227782
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13731587
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13731587
56Dialeptic seizures (HP:0011146)2.13477616
57Neuroendocrine neoplasm (HP:0100634)2.12004652
58Broad-based gait (HP:0002136)2.08421410
59Hepatic necrosis (HP:0002605)2.07510158
60Respiratory difficulties (HP:0002880)2.06841302
61Esotropia (HP:0000565)2.05744480
62Progressive inability to walk (HP:0002505)2.05352528
63Poor coordination (HP:0002370)2.03685312
64Specific learning disability (HP:0001328)2.02724504
65Abnormality of the axillary hair (HP:0100134)2.00167282
66Abnormality of secondary sexual hair (HP:0009888)2.00167282
67Abnormality of serum amino acid levels (HP:0003112)1.99837344
68Fetal akinesia sequence (HP:0001989)1.99730548
69Nephronophthisis (HP:0000090)1.98139829
70Lactic acidosis (HP:0003128)1.97011459
71Congenital ichthyosiform erythroderma (HP:0007431)1.94587759
72Microvesicular hepatic steatosis (HP:0001414)1.94352378
73Broad foot (HP:0001769)1.94139061
74Abnormality of alanine metabolism (HP:0010916)1.93578225
75Hyperalaninemia (HP:0003348)1.93578225
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93578225
77Upper limb muscle weakness (HP:0003484)1.93445807
78Focal seizures (HP:0007359)1.92120799
79Poor suck (HP:0002033)1.91730313
80Absent septum pellucidum (HP:0001331)1.91562371
81Postaxial hand polydactyly (HP:0001162)1.90985276
82Pheochromocytoma (HP:0002666)1.90068410
83Leukodystrophy (HP:0002415)1.89717372
84Methylmalonic aciduria (HP:0012120)1.88450140
85Drooling (HP:0002307)1.87962427
86Optic nerve hypoplasia (HP:0000609)1.87919236
87Aplasia/Hypoplasia of the tibia (HP:0005772)1.86970139
88Popliteal pterygium (HP:0009756)1.86468150
89Increased serum lactate (HP:0002151)1.86292090
90Decreased testicular size (HP:0008734)1.85063782
91Respiratory failure (HP:0002878)1.84791408
92Oligodactyly (hands) (HP:0001180)1.83218610
93Increased serum pyruvate (HP:0003542)1.83089049
94Abnormality of glycolysis (HP:0004366)1.83089049
95Pancreatic cysts (HP:0001737)1.82933337
96Amniotic constriction ring (HP:0009775)1.81627020
97Abnormality of placental membranes (HP:0011409)1.81627020
98Short tibia (HP:0005736)1.81587690
99Inability to walk (HP:0002540)1.81521934
100Abnormality of the septum pellucidum (HP:0007375)1.81520367
101Polyphagia (HP:0002591)1.81363218
102X-linked dominant inheritance (HP:0001423)1.80991472
103Renal cortical cysts (HP:0000803)1.80245020
104Protruding tongue (HP:0010808)1.80118105
105Anophthalmia (HP:0000528)1.80089797
106Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78842151
107Hypoglycemic coma (HP:0001325)1.78574351
108Abnormal ciliary motility (HP:0012262)1.78476124
109Meckel diverticulum (HP:0002245)1.78301066
110Labial hypoplasia (HP:0000066)1.78031272
111Cerebral edema (HP:0002181)1.76860233
112Scrotal hypoplasia (HP:0000046)1.76100468
113Median cleft lip (HP:0000161)1.76016616
114Ulnar claw (HP:0001178)1.75871250
115Postnatal microcephaly (HP:0005484)1.75689925
116Hepatoblastoma (HP:0002884)1.75360194
117Hypoplasia of the uterus (HP:0000013)1.75186981
118Abnormal respiratory motile cilium physiology (HP:0012261)1.74536735
119Progressive cerebellar ataxia (HP:0002073)1.74444417
120Abnormality of the ileum (HP:0001549)1.74322252
121Asthma (HP:0002099)1.74085795
122Bilateral microphthalmos (HP:0007633)1.73507289
123Hypoplastic female external genitalia (HP:0012815)1.73195756
124Abnormal respiratory motile cilium morphology (HP:0005938)1.73184361
125Abnormal respiratory epithelium morphology (HP:0012253)1.73184361
126Neoplasm of the adrenal gland (HP:0100631)1.72347188
127Nasolacrimal duct obstruction (HP:0000579)1.71925268
128Hyperinsulinemic hypoglycemia (HP:0000825)1.70838829
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.69222115
130Absent/shortened dynein arms (HP:0200106)1.69222115
131Male pseudohermaphroditism (HP:0000037)1.68583533
132Abnormality of the musculature of the pelvis (HP:0001469)1.67986708
133Abnormality of the hip-girdle musculature (HP:0001445)1.67986708
134Abnormality of the anterior horn cell (HP:0006802)1.67852536
135Degeneration of anterior horn cells (HP:0002398)1.67852536
136Abnormality of the lacrimal duct (HP:0011481)1.67381451
137Generalized tonic-clonic seizures (HP:0002069)1.67299626
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.66982579
139Absent eyebrow (HP:0002223)1.65625477
140Lissencephaly (HP:0001339)1.65266289
141Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.65037973
142Degeneration of the lateral corticospinal tracts (HP:0002314)1.65037973
143Type 2 muscle fiber atrophy (HP:0003554)1.64700213
144Abnormality of serine family amino acid metabolism (HP:0010894)1.64662885
145Abnormality of glycine metabolism (HP:0010895)1.64662885
146Renal tubular dysfunction (HP:0000124)1.64563807
147Shoulder girdle muscle weakness (HP:0003547)1.63852981
148Abolished electroretinogram (ERG) (HP:0000550)1.63658293
149Abnormality of the nasolacrimal system (HP:0000614)1.63524320
150Atelectasis (HP:0100750)1.63106972
151Micropenis (HP:0000054)1.62813213
152Heterochromia iridis (HP:0001100)1.62451072
153Congenital, generalized hypertrichosis (HP:0004540)1.61937266
154Abnormal pupillary function (HP:0007686)1.61881090
155Hyperthyroidism (HP:0000836)1.61608357
156Medulloblastoma (HP:0002885)1.60844007
157Aplasia/Hypoplasia of the uvula (HP:0010293)1.60344662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.44076975
2MAP3K123.47805958
3TRIM283.16137754
4STK163.13904573
5MAP2K72.65778682
6MAP4K22.35639115
7MST42.19707502
8TNIK2.12706787
9PLK21.88943235
10SIK31.87426140
11NTRK31.84594360
12MARK11.83853861
13BCR1.82410009
14BMPR1B1.77357545
15NME11.75136420
16NEK11.69932197
17MAPK131.69246508
18SRPK11.62387770
19NUAK11.59594803
20MKNK21.55246576
21ARAF1.52685780
22PBK1.48341641
23MAP3K41.46868776
24BMPR21.45288614
25DYRK21.41212796
26GRK71.38173907
27MUSK1.33117262
28ERBB31.31445614
29AKT31.30557262
30TTK1.30464742
31PINK11.29283117
32YES11.27191451
33CDK191.26996344
34PRPF4B1.26176737
35MINK11.25788040
36VRK11.25667683
37DYRK31.22935222
38GRK51.20754652
39BRAF1.19471864
40MKNK11.19046189
41ADRBK21.16921642
42WNK31.15952880
43CDC71.13549604
44RIPK41.13224846
45EPHA31.11762587
46OXSR11.11249849
47RPS6KA41.09721415
48MYLK1.06134321
49CDK81.02652193
50VRK21.00700238
51PLK10.98766765
52LIMK10.98217036
53PNCK0.97818372
54EPHA40.95500840
55CAMK2B0.89368411
56PRKCE0.85572426
57PLK30.83819048
58CSNK1G30.81644621
59CAMK2A0.78822055
60EIF2AK30.78145353
61EIF2AK20.77752815
62MAPK150.77475275
63EIF2AK10.76811794
64ERBB40.76720396
65DYRK1A0.75699471
66CSNK1G20.74889075
67PAK30.74389470
68PLK40.73740732
69ZAK0.71930029
70CDK30.71868572
71NTRK20.71426856
72TSSK60.71063761
73BCKDK0.70987338
74NEK60.70640130
75STK240.70620376
76ADRBK10.69542393
77PRKCG0.69298902
78TIE10.68256227
79DAPK10.67014020
80CCNB10.65697479
81FRK0.64374119
82FER0.63924926
83PIM20.63881110
84TLK10.63720644
85UHMK10.63376270
86BRSK20.61328392
87WEE10.60320993
88NME20.60132166
89BUB10.59757777
90BLK0.59721605
91TAF10.59600896
92STK390.58649326
93KSR10.57046000
94FES0.56983388
95CAMK2D0.56199019
96STK38L0.55786242
97CSNK1G10.54630680
98GRK10.53157164
99BRSK10.53029138
100TXK0.52760178
101FGR0.52539663
102ACVR1B0.50564148
103INSRR0.48674164
104AURKA0.47567422
105CDK140.46359443
106MAP2K40.46334529
107CSNK1A1L0.45504733
108FGFR10.45167192
109CDK50.45135852
110FLT30.43397238
111BRD40.43349539
112CAMKK20.43128523
113TGFBR10.42591466
114STK30.41082414
115OBSCN0.40825860
116SGK20.40479291
117CSNK1E0.40291828
118WNK40.40259149
119PRKACA0.40123280
120CAMK2G0.40104667
121CSNK1A10.39912613
122PIK3CG0.39744015
123CDK180.39357727
124ATM0.39163691
125TEC0.39069170
126SGK4940.38861312
127SGK2230.38861312
128PASK0.38537215
129FGFR20.38053669
130IRAK20.37435926
131TAOK30.37273030
132AURKB0.35356178
133ATR0.35326182
134CSNK2A10.34717364
135CHEK20.30713430

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.28848420
2Parkinsons disease_Homo sapiens_hsa050123.33032680
3Proteasome_Homo sapiens_hsa030503.10183221
4Nicotine addiction_Homo sapiens_hsa050332.99700918
5Steroid biosynthesis_Homo sapiens_hsa001002.84369711
6Protein export_Homo sapiens_hsa030602.79484339
7Alzheimers disease_Homo sapiens_hsa050102.75650471
8Collecting duct acid secretion_Homo sapiens_hsa049662.68903885
9Huntingtons disease_Homo sapiens_hsa050162.57517838
10Ribosome_Homo sapiens_hsa030102.28870444
11RNA polymerase_Homo sapiens_hsa030202.16296909
12Synaptic vesicle cycle_Homo sapiens_hsa047212.10207855
13Vibrio cholerae infection_Homo sapiens_hsa051102.04022965
14Propanoate metabolism_Homo sapiens_hsa006401.94315927
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82379352
16Serotonergic synapse_Homo sapiens_hsa047261.76236891
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.75886721
18Phototransduction_Homo sapiens_hsa047441.74999749
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60417642
20Taste transduction_Homo sapiens_hsa047421.50573023
21Cardiac muscle contraction_Homo sapiens_hsa042601.49209026
22Rheumatoid arthritis_Homo sapiens_hsa053231.47113027
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46862069
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.45600070
25Amphetamine addiction_Homo sapiens_hsa050311.43314928
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40502547
27Butanoate metabolism_Homo sapiens_hsa006501.37273027
28GABAergic synapse_Homo sapiens_hsa047271.36499927
29Morphine addiction_Homo sapiens_hsa050321.36468572
30Selenocompound metabolism_Homo sapiens_hsa004501.31936019
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.29266662
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27875346
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27194243
34Dopaminergic synapse_Homo sapiens_hsa047281.26796518
35Circadian entrainment_Homo sapiens_hsa047131.26189991
36Pyruvate metabolism_Homo sapiens_hsa006201.25162632
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.24293838
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22531613
39Glutamatergic synapse_Homo sapiens_hsa047241.21481951
40Basal transcription factors_Homo sapiens_hsa030221.19546719
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14135536
42Olfactory transduction_Homo sapiens_hsa047401.11448711
43DNA replication_Homo sapiens_hsa030301.11074840
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10185689
45Phagosome_Homo sapiens_hsa041451.07874736
46Cocaine addiction_Homo sapiens_hsa050301.07224604
47Cell cycle_Homo sapiens_hsa041101.03818830
48Long-term potentiation_Homo sapiens_hsa047201.03779970
49Base excision repair_Homo sapiens_hsa034101.03700997
50Regulation of autophagy_Homo sapiens_hsa041401.03261314
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03073481
52Long-term depression_Homo sapiens_hsa047301.02285148
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98244782
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95455934
55Sphingolipid metabolism_Homo sapiens_hsa006000.93809972
56Autoimmune thyroid disease_Homo sapiens_hsa053200.91152139
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89104891
58Pyrimidine metabolism_Homo sapiens_hsa002400.89027497
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88648929
60Type I diabetes mellitus_Homo sapiens_hsa049400.87133410
61Axon guidance_Homo sapiens_hsa043600.86564744
62Cholinergic synapse_Homo sapiens_hsa047250.86194184
63Peroxisome_Homo sapiens_hsa041460.85563946
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83039358
65Calcium signaling pathway_Homo sapiens_hsa040200.82349873
66Insulin secretion_Homo sapiens_hsa049110.79745474
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78438061
68mRNA surveillance pathway_Homo sapiens_hsa030150.78302470
69One carbon pool by folate_Homo sapiens_hsa006700.77694470
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77661673
71Ether lipid metabolism_Homo sapiens_hsa005650.77633490
72Purine metabolism_Homo sapiens_hsa002300.77515304
73Folate biosynthesis_Homo sapiens_hsa007900.77471822
74Nucleotide excision repair_Homo sapiens_hsa034200.76331849
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75358678
76Renin secretion_Homo sapiens_hsa049240.70514103
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69045816
78Graft-versus-host disease_Homo sapiens_hsa053320.68928156
79Spliceosome_Homo sapiens_hsa030400.67419412
80Asthma_Homo sapiens_hsa053100.66281168
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65232357
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63761257
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62946026
84Alcoholism_Homo sapiens_hsa050340.62676537
85Fatty acid elongation_Homo sapiens_hsa000620.62164717
86Tryptophan metabolism_Homo sapiens_hsa003800.61924235
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61658130
88Glutathione metabolism_Homo sapiens_hsa004800.61100854
89Salivary secretion_Homo sapiens_hsa049700.60630651
90Arachidonic acid metabolism_Homo sapiens_hsa005900.59588593
91Allograft rejection_Homo sapiens_hsa053300.59552517
92beta-Alanine metabolism_Homo sapiens_hsa004100.59216742
93Caffeine metabolism_Homo sapiens_hsa002320.58168426
94Carbon metabolism_Homo sapiens_hsa012000.58142469
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56536787
96Nitrogen metabolism_Homo sapiens_hsa009100.56387692
97RNA degradation_Homo sapiens_hsa030180.56220753
98Vitamin B6 metabolism_Homo sapiens_hsa007500.55926410
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.55735765
100Circadian rhythm_Homo sapiens_hsa047100.55082009
101p53 signaling pathway_Homo sapiens_hsa041150.54263045
102Oxytocin signaling pathway_Homo sapiens_hsa049210.53908677
103Melanogenesis_Homo sapiens_hsa049160.53682445
104Gap junction_Homo sapiens_hsa045400.53050028
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52953514
106Fatty acid metabolism_Homo sapiens_hsa012120.50756432
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49722618
108Biosynthesis of amino acids_Homo sapiens_hsa012300.49646060
109Fanconi anemia pathway_Homo sapiens_hsa034600.48468010
110Hippo signaling pathway_Homo sapiens_hsa043900.48132683
111Hedgehog signaling pathway_Homo sapiens_hsa043400.47609238
112Oocyte meiosis_Homo sapiens_hsa041140.47295162
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46425474
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46000002
115TGF-beta signaling pathway_Homo sapiens_hsa043500.43553120
116Wnt signaling pathway_Homo sapiens_hsa043100.43183850
117Ras signaling pathway_Homo sapiens_hsa040140.42492802
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42481504
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.41941554
120GnRH signaling pathway_Homo sapiens_hsa049120.41847648
121Arginine and proline metabolism_Homo sapiens_hsa003300.41763927
122Basal cell carcinoma_Homo sapiens_hsa052170.39820478
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.39623916
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39200842
125Vitamin digestion and absorption_Homo sapiens_hsa049770.39150853
126Epstein-Barr virus infection_Homo sapiens_hsa051690.38841271
127Gastric acid secretion_Homo sapiens_hsa049710.37719332
128Pancreatic secretion_Homo sapiens_hsa049720.34038979
129Melanoma_Homo sapiens_hsa052180.32656341
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32278438
131Homologous recombination_Homo sapiens_hsa034400.31462765
132cAMP signaling pathway_Homo sapiens_hsa040240.30836778
133Linoleic acid metabolism_Homo sapiens_hsa005910.29693193
134African trypanosomiasis_Homo sapiens_hsa051430.29547946
135Metabolic pathways_Homo sapiens_hsa011000.29347652
136Sulfur metabolism_Homo sapiens_hsa009200.28972463
137ErbB signaling pathway_Homo sapiens_hsa040120.28436394
138Non-homologous end-joining_Homo sapiens_hsa034500.26064596
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25446012
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25228015
141RNA transport_Homo sapiens_hsa030130.24404785
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23700140
143Mismatch repair_Homo sapiens_hsa034300.21987433

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »