MOCOS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that sulfurates the molybdenum cofactor which is required for activation of the xanthine dehydrogenase (XDH) and aldehyde oxidase (AO) enzymes. XDH catalyzes the conversion of hypoxanthine to uric acid via xanthine, as well as the conversion of allopurinol to oxypurinol, and pyrazinamide to 5-hydroxy pyrazinamide. Mutations in this gene cause the metabolic disorder classical xanthinuria type II which is characterized by the loss of XDH/XO and AO enzyme activity, decreased levels of uric acid in the urine, increased levels of xanthine and hypoxanthine in the serum and urine, formation of xanthine stones in the urinary tract, and myositis due to tissue deposition of xanthine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.64030922
2L-phenylalanine catabolic process (GO:0006559)6.64030922
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.38098975
4L-phenylalanine metabolic process (GO:0006558)6.38098975
5aromatic amino acid family catabolic process (GO:0009074)6.14245056
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.90379791
7tryptophan catabolic process (GO:0006569)5.70422727
8indole-containing compound catabolic process (GO:0042436)5.70422727
9indolalkylamine catabolic process (GO:0046218)5.70422727
10kynurenine metabolic process (GO:0070189)5.56650149
11bile acid biosynthetic process (GO:0006699)5.46109925
12urea cycle (GO:0000050)5.40997706
13urea metabolic process (GO:0019627)5.40997706
14tryptophan metabolic process (GO:0006568)5.37778459
15complement activation, alternative pathway (GO:0006957)5.24440825
16alpha-linolenic acid metabolic process (GO:0036109)5.19165535
17glyoxylate metabolic process (GO:0046487)5.16687426
18protein carboxylation (GO:0018214)5.14500120
19peptidyl-glutamic acid carboxylation (GO:0017187)5.14500120
20high-density lipoprotein particle remodeling (GO:0034375)5.11936887
21cysteine metabolic process (GO:0006534)5.11232195
22negative regulation of fibrinolysis (GO:0051918)5.03146165
23sulfur amino acid catabolic process (GO:0000098)5.00870998
24regulation of protein activation cascade (GO:2000257)5.00569928
25nitrogen cycle metabolic process (GO:0071941)4.95927163
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86586722
27regulation of fibrinolysis (GO:0051917)4.79740529
28regulation of complement activation (GO:0030449)4.71607839
29exogenous drug catabolic process (GO:0042738)4.69019889
30bile acid metabolic process (GO:0008206)4.65848271
31regulation of triglyceride catabolic process (GO:0010896)4.63647621
32regulation of cholesterol esterification (GO:0010872)4.57174322
33homocysteine metabolic process (GO:0050667)4.57073036
34serine family amino acid catabolic process (GO:0009071)4.56865393
35reverse cholesterol transport (GO:0043691)4.55768922
36phospholipid efflux (GO:0033700)4.47503004
37aromatic amino acid family metabolic process (GO:0009072)4.45313657
38plasma lipoprotein particle clearance (GO:0034381)4.43941078
39protein-lipid complex remodeling (GO:0034368)4.43584589
40macromolecular complex remodeling (GO:0034367)4.43584589
41plasma lipoprotein particle remodeling (GO:0034369)4.43584589
42amino-acid betaine metabolic process (GO:0006577)4.34184136
43lysine metabolic process (GO:0006553)4.28888382
44lysine catabolic process (GO:0006554)4.28888382
45triglyceride homeostasis (GO:0070328)4.23978610
46acylglycerol homeostasis (GO:0055090)4.23978610
47tyrosine metabolic process (GO:0006570)4.23428524
48negative regulation of sterol transport (GO:0032372)4.14200584
49negative regulation of cholesterol transport (GO:0032375)4.14200584
50cholesterol efflux (GO:0033344)4.11745236
51alpha-amino acid catabolic process (GO:1901606)4.10628338
52bile acid and bile salt transport (GO:0015721)4.08896020
53phospholipid homeostasis (GO:0055091)4.03541526
54indolalkylamine metabolic process (GO:0006586)4.01418594
55L-serine metabolic process (GO:0006563)4.00383647
56cellular glucuronidation (GO:0052695)3.99658987
57aldehyde catabolic process (GO:0046185)3.92405713
58plasma lipoprotein particle assembly (GO:0034377)3.92341442
59amine catabolic process (GO:0009310)3.90297250
60cellular biogenic amine catabolic process (GO:0042402)3.90297250
61ethanol oxidation (GO:0006069)3.87858755
62coenzyme catabolic process (GO:0009109)3.84129430
63fibrinolysis (GO:0042730)3.83141029
64imidazole-containing compound metabolic process (GO:0052803)3.80364930
65glycine metabolic process (GO:0006544)3.79754911
66benzene-containing compound metabolic process (GO:0042537)3.78828713
67cellular ketone body metabolic process (GO:0046950)3.78427270
68cellular amino acid catabolic process (GO:0009063)3.77759830
69positive regulation of lipoprotein lipase activity (GO:0051006)3.75008144
70positive regulation of triglyceride lipase activity (GO:0061365)3.75008144
71glutamate metabolic process (GO:0006536)3.74715313
72low-density lipoprotein particle remodeling (GO:0034374)3.73110149
73serine family amino acid metabolic process (GO:0009069)3.71517054
74oxidative demethylation (GO:0070989)3.69577486
75arginine metabolic process (GO:0006525)3.68860097
76cellular modified amino acid catabolic process (GO:0042219)3.68707767
77dicarboxylic acid biosynthetic process (GO:0043650)3.68149949
78positive regulation of lipid catabolic process (GO:0050996)3.66870591
79glucuronate metabolic process (GO:0019585)3.65234760
80uronic acid metabolic process (GO:0006063)3.65234760
81cholesterol homeostasis (GO:0042632)3.65207482
82sterol homeostasis (GO:0055092)3.60005426
83very-low-density lipoprotein particle assembly (GO:0034379)3.59428031
84UDP-N-acetylglucosamine metabolic process (GO:0006047)3.59259793
85protein-lipid complex assembly (GO:0065005)3.59239864
86drug catabolic process (GO:0042737)3.55939294
87cofactor catabolic process (GO:0051187)3.55419710
88regulation of cholesterol homeostasis (GO:2000188)3.55141845
89complement activation (GO:0006956)3.52791927
90plasma lipoprotein particle organization (GO:0071827)3.52169810
91complement activation, classical pathway (GO:0006958)3.51870970
92intestinal cholesterol absorption (GO:0030299)3.50861364
93protein activation cascade (GO:0072376)3.47707760
94lipoprotein metabolic process (GO:0042157)3.45687599
95serine family amino acid biosynthetic process (GO:0009070)3.42038760
96acute-phase response (GO:0006953)3.41675206
97acetyl-CoA metabolic process (GO:0006084)3.40158876
98tetrahydrofolate metabolic process (GO:0046653)3.40053717
99cytolysis (GO:0019835)3.37800186
100response to nitrosative stress (GO:0051409)3.36443082
101organic acid catabolic process (GO:0016054)3.36377439
102carboxylic acid catabolic process (GO:0046395)3.36377439
103blood coagulation, intrinsic pathway (GO:0007597)3.36179170
104protein-lipid complex subunit organization (GO:0071825)3.35541257
105nicotinamide nucleotide biosynthetic process (GO:0019359)3.32505773
106pyridine nucleotide biosynthetic process (GO:0019363)3.32505773
107regulation of hippo signaling (GO:0035330)3.22811551
108epoxygenase P450 pathway (GO:0019373)3.20962169
109flavonoid metabolic process (GO:0009812)3.20425341
110omega-hydroxylase P450 pathway (GO:0097267)3.16514119
111drug metabolic process (GO:0017144)3.16420899
112water-soluble vitamin biosynthetic process (GO:0042364)3.15101334
113aspartate family amino acid biosynthetic process (GO:0009067)3.10394015
114desmosome organization (GO:0002934)3.08886758
115drug transmembrane transport (GO:0006855)3.05898965
116nucleotide-sugar biosynthetic process (GO:0009226)3.05560563
117methionine biosynthetic process (GO:0009086)3.05072618
118regulation of translational fidelity (GO:0006450)3.05016912
119response to pheromone (GO:0019236)3.02529045
120amino acid salvage (GO:0043102)3.00910781
121L-methionine salvage (GO:0071267)3.00910781
122L-methionine biosynthetic process (GO:0071265)3.00910781
123sulfur amino acid biosynthetic process (GO:0000097)3.00000854
124folic acid-containing compound metabolic process (GO:0006760)2.96794645
125polyketide metabolic process (GO:0030638)2.93398380
126doxorubicin metabolic process (GO:0044598)2.93398380
127daunorubicin metabolic process (GO:0044597)2.93398380
128hemidesmosome assembly (GO:0031581)2.92206092
129midgut development (GO:0007494)2.88105619
130S-adenosylmethionine metabolic process (GO:0046500)2.85846546
131DNA replication checkpoint (GO:0000076)2.81889684
132negative regulation of protein activation cascade (GO:2000258)2.81541860
133methionine metabolic process (GO:0006555)2.80850746
134intestinal absorption (GO:0050892)2.76842573
135pteridine-containing compound metabolic process (GO:0042558)2.76573937
136nuclear pore complex assembly (GO:0051292)2.73799109
137folic acid metabolic process (GO:0046655)2.72367976
138aspartate family amino acid metabolic process (GO:0009066)2.71233377
139proline biosynthetic process (GO:0006561)2.65987383
140meiotic chromosome segregation (GO:0045132)2.64973865
141nuclear pore organization (GO:0006999)2.61214327
142alpha-amino acid biosynthetic process (GO:1901607)2.61061272
143pseudouridine synthesis (GO:0001522)2.60281462
144folic acid-containing compound biosynthetic process (GO:0009396)2.60171148
145tRNA aminoacylation for protein translation (GO:0006418)2.56971482
146sulfur amino acid metabolic process (GO:0000096)2.56791606
147biotin metabolic process (GO:0006768)2.56400312
148androgen biosynthetic process (GO:0006702)2.56105576
149aminoglycoside antibiotic metabolic process (GO:0030647)2.55678085
150negative regulation of complement activation (GO:0045916)2.55462025
151amino acid activation (GO:0043038)2.54261745
152tRNA aminoacylation (GO:0043039)2.54261745
153ketone body metabolic process (GO:1902224)2.53457260
154proline metabolic process (GO:0006560)2.53340457
155phenylpropanoid metabolic process (GO:0009698)2.52045600
156nucleotide-sugar metabolic process (GO:0009225)2.48248349
157maturation of 5.8S rRNA (GO:0000460)2.47593240
158ribosome biogenesis (GO:0042254)2.45786624
159regulation of plasminogen activation (GO:0010755)2.45503066
160L-alpha-amino acid transmembrane transport (GO:1902475)2.43283013

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.44561764
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.49616145
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.15909221
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.86238832
5E2F7_22180533_ChIP-Seq_HELA_Human5.47632868
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.64661379
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.60756376
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.45479279
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.54814413
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.48536421
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81175135
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.67871457
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.55410789
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.52636688
15AR_21909140_ChIP-Seq_LNCAP_Human2.28992938
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.27501859
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22468230
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.08804521
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07407223
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03897833
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03315412
22ELK1_19687146_ChIP-ChIP_HELA_Human2.03041711
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.01479138
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00240605
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4499252
26ZNF274_21170338_ChIP-Seq_K562_Hela1.98528314
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92342392
28TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.88291794
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.79357102
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78344932
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.77092288
32VDR_22108803_ChIP-Seq_LS180_Human1.73350928
33CLOCK_20551151_ChIP-Seq_293T_Human1.66350356
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66099251
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64939494
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.64414138
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64275820
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60154020
39GATA1_22025678_ChIP-Seq_K562_Human1.60147339
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54342558
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54091046
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.52560192
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.52560192
44DCP1A_22483619_ChIP-Seq_HELA_Human1.52550920
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.50270842
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50065586
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.48984571
48* E2F1_21310950_ChIP-Seq_MCF-7_Human1.48249643
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48132190
50* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45669862
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.43438501
52* MYC_18940864_ChIP-ChIP_HL60_Human1.42447211
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39919029
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39258813
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.38797921
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38724757
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35996551
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34584076
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34022340
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.33331620
61CJUN_26792858_Chip-Seq_BT549_Human1.32700572
62HNF4A_19822575_ChIP-Seq_HepG2_Human1.27971510
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.26751832
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23997741
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18238427
66ATF3_27146783_Chip-Seq_COLON_Human1.18214888
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13837069
68KDM5A_27292631_Chip-Seq_BREAST_Human1.13520421
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13228606
70EWS_26573619_Chip-Seq_HEK293_Human1.12013533
71SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11662411
72GATA3_24758297_ChIP-Seq_MCF-7_Human1.11126007
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10250614
74RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06938772
75* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06439485
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04513573
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04141226
78HTT_18923047_ChIP-ChIP_STHdh_Human1.03938552
79NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03325257
80GATA4_25053715_ChIP-Seq_YYC3_Human1.02976673
81* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02208415
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02099285
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02048041
84TTF2_22483619_ChIP-Seq_HELA_Human1.01596011
85GABP_19822575_ChIP-Seq_HepG2_Human1.00303985
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99939863
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99804264
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99224501
89TP53_16413492_ChIP-PET_HCT116_Human0.99090212
90BP1_19119308_ChIP-ChIP_Hs578T_Human0.99048437
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98506556
92ESR1_20079471_ChIP-ChIP_T-47D_Human0.98428972
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98371655
94ESR2_21235772_ChIP-Seq_MCF-7_Human0.97788585
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.96949452
96* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96142424
97ER_23166858_ChIP-Seq_MCF-7_Human0.95185089
98FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.95058025
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94777396
100HOXB7_26014856_ChIP-Seq_BT474_Human0.93753438
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.92688038
102MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90828159
103FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90653858
104POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90083135
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89825319
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89264055
107YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89085026
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88688111
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88190351
110BRD4_25478319_ChIP-Seq_HGPS_Human0.87282527
111FLI1_27457419_Chip-Seq_LIVER_Mouse0.86116092
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85520488
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.85071370
114CDX2_22108803_ChIP-Seq_LS180_Human0.84840179
115AR_20517297_ChIP-Seq_VCAP_Human0.83698601
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83272472
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83272472
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82940933
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81825642
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.81138947
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80400785
122TP63_17297297_ChIP-ChIP_HaCaT_Human0.79375345
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77873773
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77449486
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76820972
126EGR1_19032775_ChIP-ChIP_M12_Human0.75692144
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74739738
128LXR_22292898_ChIP-Seq_THP-1_Human0.73952747
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72342560
130PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.71301319
131CDX2_20551321_ChIP-Seq_CACO-2_Human0.71152312
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70896076
133GATA2_21666600_ChIP-Seq_HMVEC_Human0.70882967
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69875377
135ZNF263_19887448_ChIP-Seq_K562_Human0.69745524
136STAT3_1855785_ChIP-Seq_MESCs_Mouse0.67739972
137SOX2_20726797_ChIP-Seq_SW620_Human0.67624797
138GATA6_25053715_ChIP-Seq_YYC3_Human0.65951478
139* GATA2_19941826_ChIP-Seq_K562_Human0.65809354
140GATA1_19941827_ChIP-Seq_MEL_Mouse0.65290858
141AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65162941
142CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.64609489
143RARA_24833708_ChIP-Seq_LIVER_Mouse0.63039802
144CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62008055
145PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.61651773
146RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.61203885
147CEBPB_22108803_ChIP-Seq_LS180_Human0.60679541
148* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.60254240
149KAP1_22055183_ChIP-Seq_ESCs_Mouse0.59806355
150GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.59348926
151PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58806089
152CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.58280121
153BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58260482
154AUTS2_25519132_ChIP-Seq_293T-REX_Human0.58119002
155* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.56745654
156* GATA1_19941826_ChIP-Seq_K562_Human0.56006672
157RACK7_27058665_Chip-Seq_MCF-7_Human0.55971689
158* PU_27001747_Chip-Seq_BMDM_Mouse0.54572701
159FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54181032
160* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.54064763
161RARB_24833708_ChIP-Seq_LIVER_Mouse0.53457415
162KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.52605147
163PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.51876578
164VDR_24787735_ChIP-Seq_THP-1_Human0.51869097
165* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.51585764
166CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.51246260
167ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.50573776
168FOXA1_25552417_ChIP-Seq_VCAP_Human0.50296295
169PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.49545182
170RAD21_21589869_ChIP-Seq_MESCs_Mouse0.49435840
171SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.49085778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.32715024
2MP0005360_urolithiasis7.06741853
3MP0005085_abnormal_gallbladder_physiolo5.58272920
4MP0005365_abnormal_bile_salt5.46336500
5MP0008875_abnormal_xenobiotic_pharmacok4.52484202
6MP0009840_abnormal_foam_cell3.73270191
7MP0003806_abnormal_nucleotide_metabolis3.72056330
8MP0003252_abnormal_bile_duct3.53962128
9MP0010329_abnormal_lipoprotein_level3.40601787
10MP0005083_abnormal_biliary_tract2.83269268
11MP0003191_abnormal_cellular_cholesterol2.74081097
12MP0003941_abnormal_skin_development2.66574217
13MP0003195_calcinosis2.55840699
14MP0005332_abnormal_amino_acid2.48525510
15MP0001666_abnormal_nutrient_absorption2.41770903
16MP0003950_abnormal_plasma_membrane2.37072398
17MP0000609_abnormal_liver_physiology2.13268925
18MP0003693_abnormal_embryo_hatching2.11766272
19MP0004019_abnormal_vitamin_homeostasis2.06962469
20MP0002138_abnormal_hepatobiliary_system2.02547844
21MP0002118_abnormal_lipid_homeostasis1.98216820
22MP0000579_abnormal_nail_morphology1.96283460
23MP0005319_abnormal_enzyme/_coenzyme1.82135536
24MP0004272_abnormal_basement_membrane1.73940005
25MP0010094_abnormal_chromosome_stability1.65238589
26MP0004957_abnormal_blastocyst_morpholog1.61889591
27MP0004233_abnormal_muscle_weight1.61865922
28MP0010234_abnormal_vibrissa_follicle1.57907792
29MP0002938_white_spotting1.50759055
30MP0001764_abnormal_homeostasis1.50664811
31MP0005584_abnormal_enzyme/coenzyme_acti1.48832157
32MP0003705_abnormal_hypodermis_morpholog1.48157522
33MP0003436_decreased_susceptibility_to1.47030240
34MP0003868_abnormal_feces_composition1.45237838
35MP0010678_abnormal_skin_adnexa1.44258307
36MP0000427_abnormal_hair_cycle1.43857343
37MP0003186_abnormal_redox_activity1.40140409
38MP0009764_decreased_sensitivity_to1.39451843
39MP0000604_amyloidosis1.37370793
40MP0005058_abnormal_lysosome_morphology1.37300200
41MP0003656_abnormal_erythrocyte_physiolo1.36192304
42MP0000647_abnormal_sebaceous_gland1.34412489
43MP0009697_abnormal_copulation1.32287544
44MP0003111_abnormal_nucleus_morphology1.31370833
45MP0002254_reproductive_system_inflammat1.31271321
46MP0005451_abnormal_body_composition1.31086449
47MP0009643_abnormal_urine_homeostasis1.29816236
48MP0002060_abnormal_skin_morphology1.28724743
49MP0008058_abnormal_DNA_repair1.27339582
50MP0008469_abnormal_protein_level1.23678702
51MP0000383_abnormal_hair_follicle1.23414962
52MP0003937_abnormal_limbs/digits/tail_de1.22461719
53MP0003011_delayed_dark_adaptation1.20475776
54MP0009780_abnormal_chondrocyte_physiolo1.20112348
55MP0002160_abnormal_reproductive_system1.19761349
56MP0009763_increased_sensitivity_to1.19708438
57MP0000598_abnormal_liver_morphology1.19651527
58MP0006082_CNS_inflammation1.14757671
59MP0004043_abnormal_pH_regulation1.13832453
60MP0008438_abnormal_cutaneous_collagen1.13019694
61MP0003786_premature_aging1.12994019
62MP0000013_abnormal_adipose_tissue1.10187294
63MP0000003_abnormal_adipose_tissue1.09281285
64MP0000467_abnormal_esophagus_morphology1.08266805
65MP0003724_increased_susceptibility_to1.07105697
66MP0005464_abnormal_platelet_physiology1.06474749
67MP0000762_abnormal_tongue_morphology1.06283938
68MP0010352_gastrointestinal_tract_polyps1.06253343
69MP0002234_abnormal_pharynx_morphology1.05960955
70MP0008932_abnormal_embryonic_tissue1.05850653
71MP0005501_abnormal_skin_physiology1.02458440
72MP0002098_abnormal_vibrissa_morphology0.98846588
73MP0005551_abnormal_eye_electrophysiolog0.98534255
74MP0005171_absent_coat_pigmentation0.93657162
75MP0009785_altered_susceptibility_to0.93086949
76MP0000566_synostosis0.92805579
77MP0003077_abnormal_cell_cycle0.92593716
78MP0003690_abnormal_glial_cell0.92456047
79MP0005647_abnormal_sex_gland0.92340522
80MP0003303_peritoneal_inflammation0.90586860
81MP0009053_abnormal_anal_canal0.90461488
82MP0008872_abnormal_physiological_respon0.90298737
83MP0002419_abnormal_innate_immunity0.88985863
84MP0010771_integument_phenotype0.88596298
85MP0009642_abnormal_blood_homeostasis0.87375224
86MP0004147_increased_porphyrin_level0.84601728
87MP0005636_abnormal_mineral_homeostasis0.84451925
88MP0009765_abnormal_xenobiotic_induced0.84317600
89MP0005408_hypopigmentation0.84001692
90MP0008007_abnormal_cellular_replicative0.82762623
91MP0004130_abnormal_muscle_cell0.82402881
92MP0010030_abnormal_orbit_morphology0.82110534
93MP0001216_abnormal_epidermal_layer0.81476793
94MP0003959_abnormal_lean_body0.81367537
95MP0006054_spinal_hemorrhage0.80392129
96MP0002796_impaired_skin_barrier0.80385668
97MP0003136_yellow_coat_color0.79844436
98MP0001835_abnormal_antigen_presentation0.78789837
99MP0004947_skin_inflammation0.77861489
100MP0003075_altered_response_to0.77624998
101MP0005376_homeostasis/metabolism_phenot0.77232717
102MP0002971_abnormal_brown_adipose0.77186328
103MP0005025_abnormal_response_to0.76461505
104MP0000358_abnormal_cell_content/0.76039503
105MP0001845_abnormal_inflammatory_respons0.75104897
106MP0000627_abnormal_mammary_gland0.74935681
107MP0003172_abnormal_lysosome_physiology0.74917647
108MP0000377_abnormal_hair_follicle0.74234421
109MP0002697_abnormal_eye_size0.74160699
110MP0001853_heart_inflammation0.74041398
111MP0005410_abnormal_fertilization0.73615739
112MP0005334_abnormal_fat_pad0.73168438
113MP0005166_decreased_susceptibility_to0.72678334
114MP0005670_abnormal_white_adipose0.71317988
115MP0003566_abnormal_cell_adhesion0.70862782
116MP0010368_abnormal_lymphatic_system0.69928149
117MP0010307_abnormal_tumor_latency0.69801993
118MP0005389_reproductive_system_phenotype0.69693360
119MP0000538_abnormal_urinary_bladder0.69666846
120MP0006035_abnormal_mitochondrial_morpho0.68408794
121MP0002111_abnormal_tail_morphology0.68171308
122MP0002078_abnormal_glucose_homeostasis0.68130386
123MP0003300_gastrointestinal_ulcer0.67396322
124MP0008775_abnormal_heart_ventricle0.66408751
125MP0001533_abnormal_skeleton_physiology0.66260644
126MP0002136_abnormal_kidney_physiology0.65784488
127MP0000537_abnormal_urethra_morphology0.65546962
128MP0000639_abnormal_adrenal_gland0.64872193
129MP0001756_abnormal_urination0.64270246
130MP0004782_abnormal_surfactant_physiolog0.64180639
131MP0003699_abnormal_female_reproductive0.63971300
132MP0005167_abnormal_blood-brain_barrier0.63746974
133MP0002084_abnormal_developmental_patter0.63502198
134MP0005535_abnormal_body_temperature0.61880922
135MP0005197_abnormal_uvea_morphology0.61509962
136MP0003890_abnormal_embryonic-extraembry0.61152567
137MP0006036_abnormal_mitochondrial_physio0.57076442
138MP0005084_abnormal_gallbladder_morpholo0.56637945
139MP0005164_abnormal_response_to0.56410771
140MP0000685_abnormal_immune_system0.55909881
141MP0005266_abnormal_metabolism0.54235433
142MP0005387_immune_system_phenotype0.54012746
143MP0001790_abnormal_immune_system0.54012746
144MP0003453_abnormal_keratinocyte_physiol0.53545416
145MP0000249_abnormal_blood_vessel0.53233014
146MP0005395_other_phenotype0.53015767
147MP0005448_abnormal_energy_balance0.52691476
148MP0005023_abnormal_wound_healing0.52443386
149MP0003638_abnormal_response/metabolism_0.51272279
150MP0008873_increased_physiological_sensi0.51076639
151MP0009115_abnormal_fat_cell0.50215253
152MP0001881_abnormal_mammary_gland0.49711714
153MP0001800_abnormal_humoral_immune0.48603446
154MP0002876_abnormal_thyroid_physiology0.48409041
155MP0003329_amyloid_beta_deposits0.48168260
156MP0010155_abnormal_intestine_physiology0.47752674
157MP0004381_abnormal_hair_follicle0.46538302
158MP0001661_extended_life_span0.46141394
159MP0005000_abnormal_immune_tolerance0.45112767
160MP0002148_abnormal_hypersensitivity_rea0.44942617
161MP0003718_maternal_effect0.44524826
162MP0005220_abnormal_exocrine_pancreas0.44328914
163MP0008874_decreased_physiological_sensi0.43896146
164MP0002928_abnormal_bile_duct0.43788683
165MP0004883_abnormal_blood_vessel0.43704242

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.72807461
2Intrahepatic cholestasis (HP:0001406)6.63565431
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.41385548
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.00326536
5Xanthomatosis (HP:0000991)5.98746648
6Prolonged partial thromboplastin time (HP:0003645)5.76167039
7Hypobetalipoproteinemia (HP:0003563)5.72334238
8Complement deficiency (HP:0004431)5.38314384
9Hyperlipoproteinemia (HP:0010980)5.09132722
10Joint hemorrhage (HP:0005261)4.71153246
11Hypolipoproteinemia (HP:0010981)4.41592678
12Epidermoid cyst (HP:0200040)4.25490448
13Abnormality of the common coagulation pathway (HP:0010990)4.24917066
14Hyperammonemia (HP:0001987)4.16553558
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.15928956
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.12821815
17Abnormality of complement system (HP:0005339)4.07681505
18Fat malabsorption (HP:0002630)4.02345024
19Hypoalphalipoproteinemia (HP:0003233)3.92545162
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.91931218
21Recurrent gram-negative bacterial infections (HP:0005420)3.83530822
22Hyperglycinemia (HP:0002154)3.81596473
23Ketosis (HP:0001946)3.69547078
24Hypercholesterolemia (HP:0003124)3.68410876
25Hyperglycinuria (HP:0003108)3.65631763
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.62527317
27Systemic lupus erythematosus (HP:0002725)3.60150261
28Abnormality of methionine metabolism (HP:0010901)3.56360661
29Myocardial infarction (HP:0001658)3.55657901
30Abnormality of glycine metabolism (HP:0010895)3.51960231
31Abnormality of serine family amino acid metabolism (HP:0010894)3.51960231
32Abnormality of the intrinsic pathway (HP:0010989)3.44784657
33Abnormality of pyrimidine metabolism (HP:0004353)3.43524567
34Conjugated hyperbilirubinemia (HP:0002908)3.39210904
35Abnormality of alanine metabolism (HP:0010916)3.35088671
36Hyperalaninemia (HP:0003348)3.35088671
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.35088671
38Hypoglycemic coma (HP:0001325)3.34213271
39Abnormality of fatty-acid metabolism (HP:0004359)3.12122318
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.10900047
41Steatorrhea (HP:0002570)3.09867292
42Abnormality of nucleobase metabolism (HP:0010932)2.99180080
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.90862985
44Birth length less than 3rd percentile (HP:0003561)2.90252710
45Hyperbilirubinemia (HP:0002904)2.85007676
46Hepatocellular carcinoma (HP:0001402)2.80591488
47Chromsome breakage (HP:0040012)2.78642126
48Abnormality of purine metabolism (HP:0004352)2.77007836
49Skin nodule (HP:0200036)2.75898409
50Glomerulonephritis (HP:0000099)2.74332421
51Esophageal varix (HP:0002040)2.65869772
52Spontaneous abortion (HP:0005268)2.63205003
53Ketoacidosis (HP:0001993)2.62986247
54Vascular calcification (HP:0004934)2.62271114
55Amyloidosis (HP:0011034)2.61469959
56Abnormality of serum amino acid levels (HP:0003112)2.59882718
57Gingival bleeding (HP:0000225)2.57702494
58Delayed CNS myelination (HP:0002188)2.52505433
59Mitral stenosis (HP:0001718)2.46359300
60Metabolic acidosis (HP:0001942)2.46224282
61Hypochromic microcytic anemia (HP:0004840)2.42602117
62Spastic diplegia (HP:0001264)2.39905594
63Acanthocytosis (HP:0001927)2.36547499
64Hypoplasia of the pons (HP:0012110)2.33583861
65Cardiovascular calcification (HP:0011915)2.32689373
66Abnormality of the pons (HP:0007361)2.29822446
67Menorrhagia (HP:0000132)2.27662384
68Abnormal gallbladder morphology (HP:0012437)2.27269949
69Cholelithiasis (HP:0001081)2.25313770
70Dicarboxylic aciduria (HP:0003215)2.25185629
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25185629
72Abnormality of iron homeostasis (HP:0011031)2.22815338
73Cholecystitis (HP:0001082)2.22658594
74Abnormal gallbladder physiology (HP:0012438)2.22658594
75Malnutrition (HP:0004395)2.22278806
76Axonal loss (HP:0003447)2.21714960
77Hemorrhage of the eye (HP:0011885)2.21616622
78Abnormality of the nasal septum (HP:0000419)2.21578009
79Abnormality of proline metabolism (HP:0010907)2.21401739
80Hydroxyprolinuria (HP:0003080)2.21401739
81Pterygium (HP:0001059)2.20035799
82Sensorimotor neuropathy (HP:0007141)2.19566955
83Nephritis (HP:0000123)2.19001796
84Lethargy (HP:0001254)2.17548057
85Gout (HP:0001997)2.16140921
86Abnormality of transition element cation homeostasis (HP:0011030)2.15322119
87Abnormal hair laboratory examination (HP:0003328)2.14050465
88Chorioretinal atrophy (HP:0000533)2.12795847
89Pancreatitis (HP:0001733)2.12308240
90Fair hair (HP:0002286)2.12197675
91Irritability (HP:0000737)2.11398776
92Thrombophlebitis (HP:0004418)2.09741685
93Breast hypoplasia (HP:0003187)2.06033443
94Upper motor neuron abnormality (HP:0002127)2.04580092
95Neonatal onset (HP:0003623)2.03913762
96Abnormality of glycolysis (HP:0004366)2.01530770
97Hypoglycemic seizures (HP:0002173)1.99501547
98Renal cortical cysts (HP:0000803)1.98880062
99Duplicated collecting system (HP:0000081)1.96841337
100Abnormal enzyme/coenzyme activity (HP:0012379)1.96806537
101Abnormality of the renal cortex (HP:0011035)1.95619901
102Cerebellar dysplasia (HP:0007033)1.93431065
103Increased serum ferritin (HP:0003281)1.92655904
104Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92548672
105Nausea (HP:0002018)1.91662150
106Increased serum pyruvate (HP:0003542)1.91252757
107Opisthotonus (HP:0002179)1.89958150
108Ureteral duplication (HP:0000073)1.89020723
109Type II lissencephaly (HP:0007260)1.88706082
110Enlarged kidneys (HP:0000105)1.88461641
111Pancreatic cysts (HP:0001737)1.87656705
112Alkalosis (HP:0001948)1.87400076
113Late onset (HP:0003584)1.87217766
114Vomiting (HP:0002013)1.86800506
115Congenital stationary night blindness (HP:0007642)1.86665416
116Brittle hair (HP:0002299)1.83313999
117Abnormality of the gallbladder (HP:0005264)1.82910629
118Abnormality of the preputium (HP:0100587)1.82392414
119Pulmonary embolism (HP:0002204)1.81682685
120Vacuolated lymphocytes (HP:0001922)1.81584500
121Autoimmune thrombocytopenia (HP:0001973)1.81074119
122Elevated alkaline phosphatase (HP:0003155)1.80885985
123Cerebral edema (HP:0002181)1.80568444
124Milia (HP:0001056)1.80314735
125Plantar hyperkeratosis (HP:0007556)1.80070493
126Brushfield spots (HP:0001088)1.79679300
127Generalized aminoaciduria (HP:0002909)1.79495910
128Partial agenesis of the corpus callosum (HP:0001338)1.78617098
129Abnormality of the carotid arteries (HP:0005344)1.77151154
130Reduced antithrombin III activity (HP:0001976)1.76617826
131Poikilocytosis (HP:0004447)1.76293527
132Abnormality of subcutaneous fat tissue (HP:0001001)1.76096267
133Hypertriglyceridemia (HP:0002155)1.76078202
134Abnormal cartilage morphology (HP:0002763)1.76031164
135Upper limb muscle weakness (HP:0003484)1.75871570
136Aplasia/Hypoplasia of the uvula (HP:0010293)1.75403600
137Sparse eyelashes (HP:0000653)1.75363291
138Abnormality of alkaline phosphatase activity (HP:0004379)1.73992955
139Abnormality of homocysteine metabolism (HP:0010919)1.73016883
140Homocystinuria (HP:0002156)1.73016883
141Tubular atrophy (HP:0000092)1.72885516
142Alopecia of scalp (HP:0002293)1.70262128
143Progressive inability to walk (HP:0002505)1.69816235
144Natal tooth (HP:0000695)1.68362417
145Megaloblastic anemia (HP:0001889)1.67130599
146Meckel diverticulum (HP:0002245)1.66868398
147Glomerulosclerosis (HP:0000096)1.64740030
148Pendular nystagmus (HP:0012043)1.64588829
149Focal segmental glomerulosclerosis (HP:0000097)1.64469781
150Abnormality of the renal collecting system (HP:0004742)1.64295882
151Abnormality of the ileum (HP:0001549)1.64030664
152Popliteal pterygium (HP:0009756)1.61849940
153Redundant skin (HP:0001582)1.61298858
154Spastic paraparesis (HP:0002313)1.60180182
155Abnormality of vitamin metabolism (HP:0100508)1.59632139
156Paraparesis (HP:0002385)1.59221763
157Pancreatic fibrosis (HP:0100732)1.59153826
158Poikiloderma (HP:0001029)1.58985474
159Type I transferrin isoform profile (HP:0003642)1.57411663
160Generalized hypopigmentation of hair (HP:0011358)1.56922367
161Entropion (HP:0000621)1.56479387
162Abnormality of DNA repair (HP:0003254)1.55653440
163Decreased subcutaneous fat (HP:0001002)1.54081841
164Palmoplantar hyperkeratosis (HP:0000972)1.54040643
165Hypoplastic labia majora (HP:0000059)1.52799338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.68991300
2ERN14.54323713
3FGFR43.81156834
4SIK13.37552412
5ACVR1B3.23014997
6TAOK33.13798193
7EPHA22.95666002
8TYK22.74555880
9WNK42.67644423
10BMPR1B2.41029527
11TBK12.35407654
12ZAK2.34970741
13BUB12.34171191
14ERBB42.30341502
15TRIB32.15643713
16MAP3K142.13928934
17MST1R2.13214342
18BRSK22.09966711
19NEK12.06345804
20IRAK31.99961006
21EIF2AK11.99785723
22PKN21.99475489
23WEE11.89169753
24MST41.88682196
25STK391.87381167
26TTK1.86057698
27TSSK61.80300847
28EEF2K1.76284281
29PTK61.75819938
30INSRR1.75341097
31NEK91.75088343
32EIF2AK31.72757893
33JAK11.66158220
34MAPKAPK31.65048123
35EPHB11.60624932
36MAP2K31.59975780
37MAPK111.56761376
38STK38L1.56746304
39IKBKE1.51841610
40PDK21.49213122
41ICK1.46459692
42TLK11.43034189
43AKT31.39900375
44PIK3CG1.36973228
45JAK21.36396832
46ABL21.35691381
47MAPKAPK51.30840548
48KIT1.30390893
49NEK21.30190975
50MAP3K31.29649127
51MAP2K41.27600299
52LMTK21.23978829
53CSK1.23611662
54CDC71.22783186
55FLT31.22537993
56NME11.19820806
57TGFBR11.19687236
58GRK11.18960658
59FRK1.16028110
60CAMK1D1.15913857
61TGFBR21.12954237
62IRAK41.12837867
63RIPK11.12328861
64GRK61.12087426
65KDR1.09420280
66BLK1.06545548
67PRKAA21.06326102
68SRPK11.05022289
69MAP3K131.04900825
70MUSK1.02926864
71PLK31.02887773
72LATS11.01616684
73NUAK11.00731266
74DAPK21.00731244
75CHEK21.00608535
76MKNK21.00469257
77ADRBK20.99604956
78MAP4K10.99260279
79VRK20.96945942
80RPS6KB20.96808207
81CDK60.95017554
82MAP4K20.94523513
83PLK10.94137146
84OXSR10.92471767
85MAP3K120.90891231
86CSF1R0.88437004
87IKBKB0.87632742
88PBK0.86715364
89MKNK10.86597784
90JAK30.86207792
91EPHA30.85110825
92FGFR30.85039962
93MAP3K100.84594018
94MAP3K110.84178035
95BRSK10.83542676
96PAK40.81916349
97PRKCI0.81792703
98MAP3K70.79060790
99MELK0.77769516
100MAPK40.77404141
101CDK70.77192556
102CDK80.76497431
103ERBB30.76372571
104BMX0.75009633
105ZAP700.73289381
106PTK20.71891113
107TRIM280.71722264
108ERBB20.71633806
109PNCK0.70785438
110CHUK0.70726212
111PIM20.70278308
112AURKB0.69569605
113KSR20.67601636
114MAP3K50.67415828
115MET0.66998729
116PDPK10.66784263
117MAP3K60.64568747
118PLK40.61513267
119HCK0.60763982
120TAF10.60694185
121EGFR0.60651925
122GSK3A0.58464571
123TTN0.57667027
124SGK30.57632595
125DYRK1B0.56619127
126PRKACG0.56333514
127BTK0.55872688
128PRKCZ0.55581503
129EIF2AK20.54381153
130CSNK1G10.53749920
131MAPK120.52691675
132LATS20.52054009
133CAMK1G0.52049671
134CSNK1A1L0.52029984
135ABL10.51069116
136PDGFRA0.50949395
137ATR0.50875691
138PRKAA10.50158383
139FER0.50088936
140CSNK1G30.48762696
141RIPK40.48407321
142TRPM70.48384188
143MAP3K10.47326493
144ADRBK10.47083552
145MAP2K10.45756941
146PRKCQ0.45506833
147PIM10.45401756
148TIE10.45375707
149NTRK10.44845857
150WNK30.43703023
151ATM0.43265645
152CHEK10.43063758
153ITK0.42473908
154IGF1R0.42322414
155STK160.41584392
156RPS6KA50.41566339
157STK100.41221417
158PDK10.39272442
159STK30.39081270
160BCR0.38918136
161IRAK10.37721559
162MAP2K60.37279742
163MAP2K20.36564908
164VRK10.35748006
165AURKA0.35578335
166PRKCD0.35423864
167CSNK1E0.35338914
168SYK0.35279606
169MTOR0.34735330
170LYN0.34489912
171NME20.34175372
172RPS6KA40.33898235
173STK240.33364541
174MAP3K20.32954509
175MAP3K80.32686766
176CDK40.32259366
177PRKCE0.32259233
178FGFR20.32036615

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.46068308
2Nitrogen metabolism_Homo sapiens_hsa009103.37799374
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36122112
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.21929812
5Arginine biosynthesis_Homo sapiens_hsa002203.02273496
6Complement and coagulation cascades_Homo sapiens_hsa046102.88302470
7Tryptophan metabolism_Homo sapiens_hsa003802.62838861
8Fatty acid degradation_Homo sapiens_hsa000712.45812637
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.42672782
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.38791417
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.37357632
12Staphylococcus aureus infection_Homo sapiens_hsa051502.33076802
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31957046
14Caffeine metabolism_Homo sapiens_hsa002322.30633524
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26637450
16Peroxisome_Homo sapiens_hsa041462.06810163
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06623470
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02196014
19Histidine metabolism_Homo sapiens_hsa003401.95365848
20PPAR signaling pathway_Homo sapiens_hsa033201.94523631
21Butanoate metabolism_Homo sapiens_hsa006501.89549003
22Chemical carcinogenesis_Homo sapiens_hsa052041.89435333
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86718462
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.75304942
25Propanoate metabolism_Homo sapiens_hsa006401.73800500
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.71668906
27Fatty acid metabolism_Homo sapiens_hsa012121.69888114
28beta-Alanine metabolism_Homo sapiens_hsa004101.68306121
29Retinol metabolism_Homo sapiens_hsa008301.65980419
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49130660
31Selenocompound metabolism_Homo sapiens_hsa004501.48900576
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47626881
33Phenylalanine metabolism_Homo sapiens_hsa003601.47298641
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47012033
35Bile secretion_Homo sapiens_hsa049761.46109345
36Starch and sucrose metabolism_Homo sapiens_hsa005001.38908524
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37926585
38Tyrosine metabolism_Homo sapiens_hsa003501.32619093
39Folate biosynthesis_Homo sapiens_hsa007901.27216489
40Fat digestion and absorption_Homo sapiens_hsa049751.27032231
41ABC transporters_Homo sapiens_hsa020101.24979399
42Homologous recombination_Homo sapiens_hsa034401.24350034
43Sulfur metabolism_Homo sapiens_hsa009201.23917895
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22509316
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21853463
46Pyruvate metabolism_Homo sapiens_hsa006201.18255811
47Steroid biosynthesis_Homo sapiens_hsa001001.14860913
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.11877377
49Fatty acid elongation_Homo sapiens_hsa000621.05899888
50Carbon metabolism_Homo sapiens_hsa012001.05705863
51Biosynthesis of amino acids_Homo sapiens_hsa012301.03749252
52Nucleotide excision repair_Homo sapiens_hsa034201.03117483
53Mismatch repair_Homo sapiens_hsa034300.97191741
54Vitamin digestion and absorption_Homo sapiens_hsa049770.95360441
55Basal transcription factors_Homo sapiens_hsa030220.95015790
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93321146
57Arachidonic acid metabolism_Homo sapiens_hsa005900.92271772
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91640265
59DNA replication_Homo sapiens_hsa030300.91134018
60Vitamin B6 metabolism_Homo sapiens_hsa007500.89165396
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87679920
62Fanconi anemia pathway_Homo sapiens_hsa034600.87554146
63Non-homologous end-joining_Homo sapiens_hsa034500.87463693
64Sulfur relay system_Homo sapiens_hsa041220.87353130
65Arginine and proline metabolism_Homo sapiens_hsa003300.85382660
66RNA polymerase_Homo sapiens_hsa030200.83661496
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79561623
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79438837
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78886937
70Glycerolipid metabolism_Homo sapiens_hsa005610.78754380
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.77636073
72Lysine degradation_Homo sapiens_hsa003100.76795971
73RNA transport_Homo sapiens_hsa030130.75871334
74Pyrimidine metabolism_Homo sapiens_hsa002400.75851909
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.75219583
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72983758
77N-Glycan biosynthesis_Homo sapiens_hsa005100.71547707
78Glutathione metabolism_Homo sapiens_hsa004800.70626824
79Ether lipid metabolism_Homo sapiens_hsa005650.70531968
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70168642
81Ovarian steroidogenesis_Homo sapiens_hsa049130.67167831
82Mineral absorption_Homo sapiens_hsa049780.64605619
83Pentose phosphate pathway_Homo sapiens_hsa000300.64249659
84Protein export_Homo sapiens_hsa030600.60879322
85One carbon pool by folate_Homo sapiens_hsa006700.57613752
86RNA degradation_Homo sapiens_hsa030180.55771980
87Proteasome_Homo sapiens_hsa030500.52525334
88p53 signaling pathway_Homo sapiens_hsa041150.50301881
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50107697
90Fatty acid biosynthesis_Homo sapiens_hsa000610.49981919
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49544278
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48746443
93Purine metabolism_Homo sapiens_hsa002300.48451961
94Base excision repair_Homo sapiens_hsa034100.46842255
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45137719
96Prion diseases_Homo sapiens_hsa050200.43414302
97Cell cycle_Homo sapiens_hsa041100.43337977
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.42808315
99Sphingolipid metabolism_Homo sapiens_hsa006000.39771997
100Galactose metabolism_Homo sapiens_hsa000520.39436561
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.37383663
102Insulin resistance_Homo sapiens_hsa049310.36814750
103Metabolic pathways_Homo sapiens_hsa011000.36733939
104Fructose and mannose metabolism_Homo sapiens_hsa000510.32406750
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32002437
106Lysosome_Homo sapiens_hsa041420.25027893
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22747808
108Pertussis_Homo sapiens_hsa051330.18941458
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.18839216
110Linoleic acid metabolism_Homo sapiens_hsa005910.14806118
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13082324
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.12808320
113Leishmaniasis_Homo sapiens_hsa051400.12445003
114Malaria_Homo sapiens_hsa051440.08231035
115Hepatitis C_Homo sapiens_hsa051600.07977116
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06502078
117Legionellosis_Homo sapiens_hsa051340.04132207
118Other glycan degradation_Homo sapiens_hsa005110.03146705
119African trypanosomiasis_Homo sapiens_hsa051430.02915992
120Renin-angiotensin system_Homo sapiens_hsa046140.01412198
121TNF signaling pathway_Homo sapiens_hsa04668-0.0735545
122Insulin signaling pathway_Homo sapiens_hsa04910-0.0691973
123Influenza A_Homo sapiens_hsa05164-0.0529180
124Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0473560
125Glucagon signaling pathway_Homo sapiens_hsa04922-0.0406209
126Tuberculosis_Homo sapiens_hsa05152-0.0400180
127Osteoclast differentiation_Homo sapiens_hsa04380-0.0359703
128Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0274356
129NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0260996
130Amoebiasis_Homo sapiens_hsa05146-0.0031534
131AMPK signaling pathway_Homo sapiens_hsa04152-0.0005495

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