MOCS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.07274984
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.07274984
3L-phenylalanine metabolic process (GO:0006558)5.72007534
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.72007534
5aromatic amino acid family catabolic process (GO:0009074)5.27633581
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.91424523
7aldehyde catabolic process (GO:0046185)4.86930745
8indole-containing compound catabolic process (GO:0042436)4.63019678
9indolalkylamine catabolic process (GO:0046218)4.63019678
10tryptophan catabolic process (GO:0006569)4.63019678
11bile acid biosynthetic process (GO:0006699)4.55035924
12tryptophan metabolic process (GO:0006568)4.38440429
13glyoxylate metabolic process (GO:0046487)4.34616456
14high-density lipoprotein particle remodeling (GO:0034375)4.14743311
15kynurenine metabolic process (GO:0070189)4.11930738
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.11700059
17cysteine metabolic process (GO:0006534)4.01291487
18alpha-linolenic acid metabolic process (GO:0036109)3.89646166
19bile acid metabolic process (GO:0008206)3.86512580
20cellular ketone body metabolic process (GO:0046950)3.86144173
21cellular biogenic amine catabolic process (GO:0042402)3.85578941
22amine catabolic process (GO:0009310)3.85578941
23tyrosine metabolic process (GO:0006570)3.85411759
24aromatic amino acid family metabolic process (GO:0009072)3.82959220
25coenzyme catabolic process (GO:0009109)3.81169936
26sulfur amino acid catabolic process (GO:0000098)3.80870997
27uronic acid metabolic process (GO:0006063)3.79466411
28glucuronate metabolic process (GO:0019585)3.79466411
29regulation of cholesterol esterification (GO:0010872)3.77834744
30regulation of triglyceride catabolic process (GO:0010896)3.74893226
31fatty acid elongation (GO:0030497)3.74576054
32reverse cholesterol transport (GO:0043691)3.73785172
33cellular glucuronidation (GO:0052695)3.72294305
34peptidyl-glutamic acid carboxylation (GO:0017187)3.71531389
35protein carboxylation (GO:0018214)3.71531389
36plasma lipoprotein particle remodeling (GO:0034369)3.69052157
37protein-lipid complex remodeling (GO:0034368)3.69052157
38macromolecular complex remodeling (GO:0034367)3.69052157
39urea cycle (GO:0000050)3.67072700
40urea metabolic process (GO:0019627)3.67072700
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.65159001
42complement activation, alternative pathway (GO:0006957)3.62728744
43regulation of fibrinolysis (GO:0051917)3.61924351
44acylglycerol homeostasis (GO:0055090)3.56916689
45triglyceride homeostasis (GO:0070328)3.56916689
46phospholipid efflux (GO:0033700)3.56140908
47respiratory electron transport chain (GO:0022904)3.54531395
48cofactor catabolic process (GO:0051187)3.50193110
49indolalkylamine metabolic process (GO:0006586)3.49139276
50nitrogen cycle metabolic process (GO:0071941)3.48968596
51plasma lipoprotein particle clearance (GO:0034381)3.47364322
52regulation of protein activation cascade (GO:2000257)3.46018941
53electron transport chain (GO:0022900)3.45301228
54very long-chain fatty acid metabolic process (GO:0000038)3.45133857
55negative regulation of fibrinolysis (GO:0051918)3.45034252
56proteasome assembly (GO:0043248)3.41073790
57cullin deneddylation (GO:0010388)3.40161286
58cholesterol efflux (GO:0033344)3.38562231
59alpha-amino acid catabolic process (GO:1901606)3.34600580
60ketone body metabolic process (GO:1902224)3.34599655
61homocysteine metabolic process (GO:0050667)3.33364323
62ATP synthesis coupled proton transport (GO:0015986)3.31565945
63energy coupled proton transport, down electrochemical gradient (GO:0015985)3.31565945
64short-chain fatty acid metabolic process (GO:0046459)3.24216164
65bile acid and bile salt transport (GO:0015721)3.23854064
66low-density lipoprotein particle remodeling (GO:0034374)3.21491816
67benzene-containing compound metabolic process (GO:0042537)3.21435807
68regulation of complement activation (GO:0030449)3.21259105
69NAD biosynthetic process (GO:0009435)3.20962225
70establishment of protein localization to mitochondrial membrane (GO:0090151)3.18959136
71amino-acid betaine metabolic process (GO:0006577)3.15779885
72cellular amino acid catabolic process (GO:0009063)3.15306734
73regulation of mitochondrial translation (GO:0070129)3.12161869
74regulation of cell communication by electrical coupling (GO:0010649)3.10765742
75opsonization (GO:0008228)3.08635111
76glutamate metabolic process (GO:0006536)3.07380342
77monocarboxylic acid catabolic process (GO:0072329)3.06517042
78negative regulation of lipase activity (GO:0060192)3.05732529
79protein complex biogenesis (GO:0070271)3.05278622
80positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.05111467
81acetyl-CoA metabolic process (GO:0006084)3.04104670
82nicotinamide nucleotide biosynthetic process (GO:0019359)3.00802440
83pyridine nucleotide biosynthetic process (GO:0019363)3.00802440
84drug catabolic process (GO:0042737)3.00088547
85carboxylic acid catabolic process (GO:0046395)2.99324345
86organic acid catabolic process (GO:0016054)2.99324345
87protein deneddylation (GO:0000338)2.98344586
88fatty acid catabolic process (GO:0009062)2.97889929
89response to nitrosative stress (GO:0051409)2.97412411
90serine family amino acid catabolic process (GO:0009071)2.97154384
91tricarboxylic acid cycle (GO:0006099)2.96793641
92cellular modified amino acid catabolic process (GO:0042219)2.93791475
93fatty acid beta-oxidation (GO:0006635)2.93772011
94lysine catabolic process (GO:0006554)2.93072323
95lysine metabolic process (GO:0006553)2.93072323
96fatty acid oxidation (GO:0019395)2.92621331
97ethanol oxidation (GO:0006069)2.92531660
98chaperone-mediated protein transport (GO:0072321)2.92044567
99negative regulation of sterol transport (GO:0032372)2.91705269
100negative regulation of cholesterol transport (GO:0032375)2.91705269
101thioester metabolic process (GO:0035383)2.91066928
102acyl-CoA metabolic process (GO:0006637)2.91066928
103fibrinolysis (GO:0042730)2.90348168
104imidazole-containing compound metabolic process (GO:0052803)2.90288429
105lipid oxidation (GO:0034440)2.90275342
106positive regulation of lipoprotein lipase activity (GO:0051006)2.88203412
107positive regulation of triglyceride lipase activity (GO:0061365)2.88203412
108fatty-acyl-CoA biosynthetic process (GO:0046949)2.86813626
109flavonoid metabolic process (GO:0009812)2.86422542
110positive regulation of lipid catabolic process (GO:0050996)2.84161332
111arginine metabolic process (GO:0006525)2.83910921
112ethanol metabolic process (GO:0006067)2.83221384
113positive regulation of actin filament depolymerization (GO:0030836)2.82750804
114regulation of bile acid biosynthetic process (GO:0070857)2.82567486
115mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.82530755
116very-low-density lipoprotein particle assembly (GO:0034379)2.80878271
117mitochondrial respiratory chain complex I assembly (GO:0032981)2.80790955
118NADH dehydrogenase complex assembly (GO:0010257)2.80790955
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80790955
120mitochondrial respiratory chain complex assembly (GO:0033108)2.80516752
121branched-chain amino acid catabolic process (GO:0009083)2.75516813
122heart contraction (GO:0060047)2.74579720
123heart process (GO:0003015)2.74579720
124negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.71460282
125cellular potassium ion homeostasis (GO:0030007)2.67057344
126regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.66376641
127regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.62393463
128protein maturation by protein folding (GO:0022417)2.61687034
129glutamate secretion (GO:0014047)2.55729859
130establishment of integrated proviral latency (GO:0075713)2.53889068
131detection of calcium ion (GO:0005513)2.48417233
132regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.47023693
133regulation of relaxation of muscle (GO:1901077)2.45155214
134regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.44590171
135rRNA modification (GO:0000154)2.43757816
136oxidative phosphorylation (GO:0006119)2.42352379
137membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40888908
138respiratory chain complex IV assembly (GO:0008535)2.40167187
139actin-myosin filament sliding (GO:0033275)2.37537269
140muscle filament sliding (GO:0030049)2.37537269
141regulation of acyl-CoA biosynthetic process (GO:0050812)2.33952343
142water-soluble vitamin biosynthetic process (GO:0042364)2.33328968
143lipid particle organization (GO:0034389)2.31499084
144L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.28900739
145regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.26866412
146regulation of oxidative phosphorylation (GO:0002082)2.26091458
147regulation of cofactor metabolic process (GO:0051193)2.24146822
148regulation of coenzyme metabolic process (GO:0051196)2.24146822
149relaxation of smooth muscle (GO:0044557)2.22122194
150positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.21469871
151negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.21325483
152response to redox state (GO:0051775)2.21215967
153L-methionine salvage (GO:0071267)2.20827425
154L-methionine biosynthetic process (GO:0071265)2.20827425
155amino acid salvage (GO:0043102)2.20827425
156regulation of hexokinase activity (GO:1903299)2.20732755
157regulation of glucokinase activity (GO:0033131)2.20732755
158rRNA methylation (GO:0031167)2.20347969
159regulation of actin filament-based movement (GO:1903115)2.19790535
160protein heterotetramerization (GO:0051290)2.18886432
161regulation of cellular amino acid metabolic process (GO:0006521)2.18582513
162positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.18103140
163protein targeting to mitochondrion (GO:0006626)2.16847050
164intracellular protein transmembrane import (GO:0044743)2.16269153
165cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.15117073
166protein neddylation (GO:0045116)2.15111885
167actin-mediated cell contraction (GO:0070252)2.14287683
168synaptic vesicle maturation (GO:0016188)2.13349147
169hydrogen ion transmembrane transport (GO:1902600)2.12418380
170muscle cell cellular homeostasis (GO:0046716)2.11962304
171regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.11343573
172negative regulation of calcium ion transmembrane transport (GO:1903170)2.11167616
173negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.11167616
174anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.10912681
175ATP biosynthetic process (GO:0006754)2.10238076
176protein localization to mitochondrion (GO:0070585)2.09622242
177regulation of sulfur metabolic process (GO:0042762)2.05907838
178ribosome assembly (GO:0042255)2.05701355
179pteridine-containing compound biosynthetic process (GO:0042559)2.05383311
180negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.03898439
181negative regulation of ligase activity (GO:0051352)2.03898439
182lactate metabolic process (GO:0006089)2.03686081
183purine nucleoside triphosphate biosynthetic process (GO:0009145)2.03161781
184establishment of protein localization to mitochondrion (GO:0072655)2.02748857
185positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.02693238
186vascular smooth muscle contraction (GO:0014829)2.02367137
187peroxisome fission (GO:0016559)2.00945321
188cytochrome complex assembly (GO:0017004)2.00255554
189mitochondrial transport (GO:0006839)1.99334504
190synaptic vesicle docking involved in exocytosis (GO:0016081)1.99155607
191positive regulation of ubiquitin-protein transferase activity (GO:0051443)1.99033559
192regulation of cardiac muscle cell contraction (GO:0086004)1.98783140
193artery smooth muscle contraction (GO:0014824)1.97979410
194ribonucleoprotein complex disassembly (GO:0032988)1.96475378

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.14068539
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.34695582
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.26957104
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.52886667
5* LXR_22158963_ChIP-Seq_LIVER_Mouse3.45974309
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.44342797
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.10577102
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.93243054
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.90863025
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.80958985
11GBX2_23144817_ChIP-Seq_PC3_Human2.78292484
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43033917
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.34459000
14TAF15_26573619_Chip-Seq_HEK293_Human2.19290863
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17123427
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.06702021
17* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99533675
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.99231538
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.96895805
20FUS_26573619_Chip-Seq_HEK293_Human1.95504629
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94505047
22ELK1_19687146_ChIP-ChIP_HELA_Human1.93602362
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90771769
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84972146
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82220622
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81837852
27HTT_18923047_ChIP-ChIP_STHdh_Human1.73170390
28ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.70121167
29AR_21909140_ChIP-Seq_LNCAP_Human1.67689358
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.63929259
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53874037
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53452525
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53363636
34EWS_26573619_Chip-Seq_HEK293_Human1.52356187
35IGF1R_20145208_ChIP-Seq_DFB_Human1.50077337
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48657914
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.47523560
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46754784
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46754784
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46671353
41* SRF_21415370_ChIP-Seq_HL-1_Mouse1.46439377
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44735954
43P300_19829295_ChIP-Seq_ESCs_Human1.43354181
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42856102
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41680211
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.38886883
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37631798
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37004747
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36694732
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.36142081
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.32718042
52MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.29810828
53* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27960960
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27470945
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26221649
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25459736
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25064539
58DCP1A_22483619_ChIP-Seq_HELA_Human1.24071403
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23940678
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21690583
61VDR_22108803_ChIP-Seq_LS180_Human1.21682683
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21008514
63EZH2_22144423_ChIP-Seq_EOC_Human1.19432683
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17037469
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16719905
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15843278
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15194801
68BCAT_22108803_ChIP-Seq_LS180_Human1.15190825
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14940291
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14663300
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14312804
72SMAD4_21799915_ChIP-Seq_A2780_Human1.14071333
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13676168
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13002380
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12967482
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11778564
77* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11606112
78VDR_23849224_ChIP-Seq_CD4+_Human1.10008038
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09149283
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08597637
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08353714
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07877166
83SOX17_20123909_ChIP-Seq_XEN_Mouse1.07501927
84JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07442549
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07277695
86P53_22387025_ChIP-Seq_ESCs_Mouse1.06993870
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06854062
88ER_23166858_ChIP-Seq_MCF-7_Human1.05941940
89TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04447785
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.04339048
91RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04017515
92* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03837050
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03186990
94EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02645892
95RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02645892
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.02278589
97SOX9_26525672_Chip-Seq_HEART_Mouse1.02131130
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.01520853
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.01255459
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00884402
101GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00670247
102* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00628080
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.00297051
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00237820
105ELK1_22589737_ChIP-Seq_MCF10A_Human1.00218383
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99992635
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99008998
108NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98375262
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98263934
110EZH2_27304074_Chip-Seq_ESCs_Mouse0.97801940
111E2F4_17652178_ChIP-ChIP_JURKAT_Human0.96387127
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95936174
113P300_18555785_Chip-Seq_ESCs_Mouse0.95224038
114EZH2_27294783_Chip-Seq_ESCs_Mouse0.95186407
115CMYC_18555785_Chip-Seq_ESCs_Mouse0.95008819
116CBX2_27304074_Chip-Seq_ESCs_Mouse0.94619615
117STAT3_18555785_Chip-Seq_ESCs_Mouse0.94408006
118TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94174252
119KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93668613
120E2F1_18555785_Chip-Seq_ESCs_Mouse0.93539593
121* TAL1_26923725_Chip-Seq_HPCs_Mouse0.93532020
122ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93258095
123SOX2_18555785_Chip-Seq_ESCs_Mouse0.92844533
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92490278
125* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92264153
126KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92004270
127SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91961355
128* JUN_21703547_ChIP-Seq_K562_Human0.91744603
129MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91680004
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91552356
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91485534
132* TP53_18474530_ChIP-ChIP_U2OS_Human0.91028854
133* GABP_19822575_ChIP-Seq_HepG2_Human0.90873511
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90790279
135EOMES_21245162_ChIP-Seq_HESCs_Human0.90756418
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90285532
137AR_21572438_ChIP-Seq_LNCaP_Human0.90249618
138AR_25329375_ChIP-Seq_VCAP_Human0.90082701
139TRIM28_21343339_ChIP-Seq_HEK293_Human0.89832970
140MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89665516
141TTF2_22483619_ChIP-Seq_HELA_Human0.89434231
142SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88886281
143MYC_19030024_ChIP-ChIP_MESCs_Mouse0.88802555
144CRX_20693478_ChIP-Seq_RETINA_Mouse0.88797968
145RNF2_27304074_Chip-Seq_NSC_Mouse0.88190705
146CBP_21632823_ChIP-Seq_H3396_Human0.88059260
147PU1_27457419_Chip-Seq_LIVER_Mouse0.87123577
148PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87074834
149SOX2_19829295_ChIP-Seq_ESCs_Human0.85584066
150NANOG_19829295_ChIP-Seq_ESCs_Human0.85584066
151BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85016386
152KDM2B_26808549_Chip-Seq_REH_Human0.84430951
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84330721
154NMYC_18555785_Chip-Seq_ESCs_Mouse0.83278949
155OCT4_18555785_Chip-Seq_ESCs_Mouse0.81890913
156IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81014021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.34597656
2MP0005360_urolithiasis6.00518945
3MP0005085_abnormal_gallbladder_physiolo5.07173284
4MP0005365_abnormal_bile_salt4.84285167
5MP0008875_abnormal_xenobiotic_pharmacok4.15355526
6MP0003195_calcinosis3.38386915
7MP0003806_abnormal_nucleotide_metabolis3.04482342
8MP0003252_abnormal_bile_duct2.96873126
9MP0009780_abnormal_chondrocyte_physiolo2.81399435
10MP0005083_abnormal_biliary_tract2.78907180
11MP0010329_abnormal_lipoprotein_level2.67721339
12MP0005332_abnormal_amino_acid2.42894206
13MP0000749_muscle_degeneration2.41747487
14MP0004270_analgesia2.37575959
15MP0000751_myopathy2.22820914
16MP0004859_abnormal_synaptic_plasticity2.21875713
17MP0001666_abnormal_nutrient_absorption2.12603308
18MP0004215_abnormal_myocardial_fiber2.12342938
19MP0002876_abnormal_thyroid_physiology2.07354208
20MP0009840_abnormal_foam_cell1.97428507
21MP0009697_abnormal_copulation1.96648432
22MP0004019_abnormal_vitamin_homeostasis1.87387815
23MP0002118_abnormal_lipid_homeostasis1.79369475
24MP0004145_abnormal_muscle_electrophysio1.78321246
25MP0009046_muscle_twitch1.78078311
26MP0009379_abnormal_foot_pigmentation1.69838795
27MP0005451_abnormal_body_composition1.64622067
28MP0003186_abnormal_redox_activity1.57007652
29MP0004084_abnormal_cardiac_muscle1.53078192
30MP0001764_abnormal_homeostasis1.51927108
31MP0002234_abnormal_pharynx_morphology1.50608980
32MP0002138_abnormal_hepatobiliary_system1.50130665
33MP0006072_abnormal_retinal_apoptosis1.47088872
34MP0005584_abnormal_enzyme/coenzyme_acti1.45964496
35MP0003191_abnormal_cellular_cholesterol1.45157195
36MP0003868_abnormal_feces_composition1.44213845
37MP0006276_abnormal_autonomic_nervous1.41486733
38MP0003011_delayed_dark_adaptation1.41235152
39MP0005330_cardiomyopathy1.38716158
40MP0000609_abnormal_liver_physiology1.36174052
41MP0003635_abnormal_synaptic_transmissio1.36128710
42MP0004036_abnormal_muscle_relaxation1.32913806
43MP0001299_abnormal_eye_distance/1.32310559
44MP0010368_abnormal_lymphatic_system1.29775489
45MP0003724_increased_susceptibility_to1.25102193
46MP0005319_abnormal_enzyme/_coenzyme1.24683643
47MP0000013_abnormal_adipose_tissue1.23400133
48MP0005423_abnormal_somatic_nervous1.23032364
49MP0009764_decreased_sensitivity_to1.22461298
50MP0005535_abnormal_body_temperature1.22410186
51MP0005646_abnormal_pituitary_gland1.21989153
52MP0002269_muscular_atrophy1.19222956
53MP0003690_abnormal_glial_cell1.18756969
54MP0002736_abnormal_nociception_after1.17257348
55MP0002909_abnormal_adrenal_gland1.16403891
56MP0002254_reproductive_system_inflammat1.16300895
57MP0005408_hypopigmentation1.14773205
58MP0002063_abnormal_learning/memory/cond1.12720882
59MP0003880_abnormal_central_pattern1.11751551
60MP0005187_abnormal_penis_morphology1.11383158
61MP0005636_abnormal_mineral_homeostasis1.10970928
62MP0005171_absent_coat_pigmentation1.09783185
63MP0004043_abnormal_pH_regulation1.08537055
64MP0005620_abnormal_muscle_contractility1.07554180
65MP0002938_white_spotting1.07522335
66MP0009643_abnormal_urine_homeostasis1.07442483
67MP0002837_dystrophic_cardiac_calcinosis1.07018686
68MP0001984_abnormal_olfaction1.06701479
69MP0000747_muscle_weakness1.06684315
70MP0002735_abnormal_chemical_nociception1.05414224
71MP0004142_abnormal_muscle_tone1.05066919
72MP0002972_abnormal_cardiac_muscle1.03031876
73MP0001968_abnormal_touch/_nociception1.01882070
74MP0008058_abnormal_DNA_repair1.01342104
75MP0003137_abnormal_impulse_conducting1.00428534
76MP0005084_abnormal_gallbladder_morpholo0.98220149
77MP0000778_abnormal_nervous_system0.97113779
78MP0000604_amyloidosis0.96561037
79MP0005379_endocrine/exocrine_gland_phen0.95770680
80MP0006036_abnormal_mitochondrial_physio0.95736535
81MP0004885_abnormal_endolymph0.95538996
82MP0005647_abnormal_sex_gland0.95362927
83MP0008775_abnormal_heart_ventricle0.94919578
84MP0003183_abnormal_peptide_metabolism0.94715673
85MP0002102_abnormal_ear_morphology0.92831620
86MP0001986_abnormal_taste_sensitivity0.91988767
87MP0003950_abnormal_plasma_membrane0.91932255
88MP0002822_catalepsy0.91711570
89MP0005623_abnormal_meninges_morphology0.91698027
90MP0004087_abnormal_muscle_fiber0.91595991
91MP0002557_abnormal_social/conspecific_i0.90244259
92MP0002638_abnormal_pupillary_reflex0.90000778
93MP0005248_abnormal_Harderian_gland0.89933980
94MP0008789_abnormal_olfactory_epithelium0.89689844
95MP0004085_abnormal_heartbeat0.89204613
96MP0001542_abnormal_bone_strength0.87804649
97MP0005253_abnormal_eye_physiology0.87237546
98MP0004924_abnormal_behavior0.86389525
99MP0005386_behavior/neurological_phenoty0.86389525
100MP0000759_abnormal_skeletal_muscle0.86354372
101MP0004381_abnormal_hair_follicle0.86190556
102MP0002106_abnormal_muscle_physiology0.85965909
103MP0001501_abnormal_sleep_pattern0.85565126
104MP0000569_abnormal_digit_pigmentation0.84476686
105MP0002090_abnormal_vision0.84309745
106MP0004130_abnormal_muscle_cell0.82943128
107MP0000920_abnormal_myelination0.82718790
108MP0002160_abnormal_reproductive_system0.82716611
109MP0001661_extended_life_span0.81474279
110MP0006035_abnormal_mitochondrial_morpho0.81304498
111MP0005551_abnormal_eye_electrophysiolog0.80189567
112MP0001486_abnormal_startle_reflex0.80051443
113MP0010030_abnormal_orbit_morphology0.79609831
114MP0010386_abnormal_urinary_bladder0.79311577
115MP0003633_abnormal_nervous_system0.78943363
116MP0005369_muscle_phenotype0.78617794
117MP0002078_abnormal_glucose_homeostasis0.77918987
118MP0001905_abnormal_dopamine_level0.77857030
119MP0001879_abnormal_lymphatic_vessel0.77179714
120MP0008932_abnormal_embryonic_tissue0.76824757
121MP0002066_abnormal_motor_capabilities/c0.75080731
122MP0009763_increased_sensitivity_to0.75031768
123MP0002184_abnormal_innervation0.74759432
124MP0008872_abnormal_physiological_respon0.73607980
125MP0003329_amyloid_beta_deposits0.73291603
126MP0005058_abnormal_lysosome_morphology0.72970760
127MP0005376_homeostasis/metabolism_phenot0.72827887
128MP0005645_abnormal_hypothalamus_physiol0.72363826
129MP0002733_abnormal_thermal_nociception0.71813464
130MP0008469_abnormal_protein_level0.71704953
131MP0005334_abnormal_fat_pad0.71444304
132MP0000230_abnormal_systemic_arterial0.71159588
133MP0005670_abnormal_white_adipose0.71016564
134MP0010234_abnormal_vibrissa_follicle0.70272607
135MP0002064_seizures0.70200331
136MP0001529_abnormal_vocalization0.70133544
137MP0001440_abnormal_grooming_behavior0.69939836
138MP0004484_altered_response_of0.69924074
139MP0009765_abnormal_xenobiotic_induced0.69176462
140MP0004782_abnormal_surfactant_physiolog0.69025735
141MP0004272_abnormal_basement_membrane0.68666689
142MP0002877_abnormal_melanocyte_morpholog0.68593738
143MP0009642_abnormal_blood_homeostasis0.68591211
144MP0000955_abnormal_spinal_cord0.68313433
145MP0003656_abnormal_erythrocyte_physiolo0.68079766
146MP0009745_abnormal_behavioral_response0.66205586
147MP0002272_abnormal_nervous_system0.65693334
148MP0002067_abnormal_sensory_capabilities0.62631690
149MP0002734_abnormal_mechanical_nocicepti0.62569012
150MP0004742_abnormal_vestibular_system0.61906997
151MP0008004_abnormal_stomach_pH0.60386468
152MP0000639_abnormal_adrenal_gland0.59394925
153MP0005448_abnormal_energy_balance0.58495224
154MP0001756_abnormal_urination0.58474873
155MP0000538_abnormal_urinary_bladder0.57322710
156MP0002295_abnormal_pulmonary_circulatio0.57284499
157MP0002572_abnormal_emotion/affect_behav0.57248245
158MP0006082_CNS_inflammation0.54514503
159MP0008874_decreased_physiological_sensi0.54138005
160MP0002971_abnormal_brown_adipose0.53357603
161MP0004147_increased_porphyrin_level0.53071511
162MP0001970_abnormal_pain_threshold0.52823981

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.23884192
2Prolonged partial thromboplastin time (HP:0003645)5.40094598
3Intrahepatic cholestasis (HP:0001406)5.06371175
4Xanthomatosis (HP:0000991)4.75526581
5Deep venous thrombosis (HP:0002625)4.49660348
6Hypobetalipoproteinemia (HP:0003563)4.46938823
7Hyperlipoproteinemia (HP:0010980)4.27191463
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.15996184
9Conjugated hyperbilirubinemia (HP:0002908)3.86860638
10Joint hemorrhage (HP:0005261)3.80937250
11Complement deficiency (HP:0004431)3.57715837
12Cerebral edema (HP:0002181)3.52942915
13Acute encephalopathy (HP:0006846)3.47747876
14Abnormality of glutamine family amino acid metabolism (HP:0010902)3.45480127
15Epidermoid cyst (HP:0200040)3.42532459
16Ketosis (HP:0001946)3.40912930
17Hypolipoproteinemia (HP:0010981)3.33549532
18Hypoglycemic coma (HP:0001325)3.33089606
19Hyperglycinemia (HP:0002154)3.29583236
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.23119517
21Nemaline bodies (HP:0003798)3.18516465
22Fat malabsorption (HP:0002630)3.16135466
23Acute necrotizing encephalopathy (HP:0006965)3.12959599
24Abnormality of glycine metabolism (HP:0010895)3.12534986
25Abnormality of serine family amino acid metabolism (HP:0010894)3.12534986
26Hyperammonemia (HP:0001987)3.11006419
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.10647762
28Hyperglycinuria (HP:0003108)3.09559589
29Increased hepatocellular lipid droplets (HP:0006565)3.08468404
30Hepatic necrosis (HP:0002605)3.04351061
31Abnormality of the common coagulation pathway (HP:0010990)3.02470974
32Muscle fiber inclusion bodies (HP:0100299)2.92886896
33Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.90650223
34Abnormality of fatty-acid metabolism (HP:0004359)2.90045658
35Abnormal mitochondria in muscle tissue (HP:0008316)2.89388224
36Exercise-induced muscle cramps (HP:0003710)2.87419576
37Hypoalphalipoproteinemia (HP:0003233)2.85982320
38Abnormality of the intrinsic pathway (HP:0010989)2.85277283
39Generalized aminoaciduria (HP:0002909)2.84441668
40Abnormality of methionine metabolism (HP:0010901)2.81245281
41Focal motor seizures (HP:0011153)2.79158597
42Lethargy (HP:0001254)2.75881778
43Mitochondrial inheritance (HP:0001427)2.71887666
44Progressive macrocephaly (HP:0004481)2.69866608
45Ketoacidosis (HP:0001993)2.67811497
46Myokymia (HP:0002411)2.66095419
47Hepatocellular necrosis (HP:0001404)2.64989865
48Abnormality of sulfur amino acid metabolism (HP:0004339)2.64940822
49Bundle branch block (HP:0011710)2.57541863
50Parakeratosis (HP:0001036)2.53384579
51Abnormality of urine glucose concentration (HP:0011016)2.53283132
52Glycosuria (HP:0003076)2.53283132
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.51600251
54Metabolic acidosis (HP:0001942)2.51411077
55Hypercholesterolemia (HP:0003124)2.50867851
56Calf muscle hypertrophy (HP:0008981)2.50711104
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48298653
58Dicarboxylic aciduria (HP:0003215)2.48298653
59Neuroendocrine neoplasm (HP:0100634)2.44451843
60Increased serum pyruvate (HP:0003542)2.44143283
61Abnormality of glycolysis (HP:0004366)2.44143283
62Hyperbilirubinemia (HP:0002904)2.43115174
63Abnormality of complement system (HP:0005339)2.42716196
64Steatorrhea (HP:0002570)2.42206287
65Action tremor (HP:0002345)2.42132473
66Vomiting (HP:0002013)2.39964433
67Hyperventilation (HP:0002883)2.38127617
68Atonic seizures (HP:0010819)2.38001320
69Abnormality of the calf musculature (HP:0001430)2.37872815
70Systemic lupus erythematosus (HP:0002725)2.36930571
71Abnormality of serum amino acid levels (HP:0003112)2.36637976
72Delayed CNS myelination (HP:0002188)2.34497743
73Muscle hypertrophy of the lower extremities (HP:0008968)2.34120535
74Exercise intolerance (HP:0003546)2.31793494
75Increased CSF lactate (HP:0002490)2.30626471
76Respiratory failure (HP:0002878)2.29032263
77Hypoglycemic seizures (HP:0002173)2.27282881
78Leukodystrophy (HP:0002415)2.27081234
79Renal cortical cysts (HP:0000803)2.25243704
80Renal Fanconi syndrome (HP:0001994)2.25142969
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.24504929
82Decreased activity of mitochondrial respiratory chain (HP:0008972)2.24504929
83Proximal tubulopathy (HP:0000114)2.21467981
84Hypothermia (HP:0002045)2.20632325
85Nausea (HP:0002018)2.18415776
86* Abnormality of purine metabolism (HP:0004352)2.17252664
87Sudden death (HP:0001699)2.14896173
88Hypophosphatemic rickets (HP:0004912)2.11755471
89Palpitations (HP:0001962)2.10252787
90Fair hair (HP:0002286)2.10235559
91Increased intramyocellular lipid droplets (HP:0012240)2.07493198
92Myoglobinuria (HP:0002913)2.06849363
93Skin nodule (HP:0200036)2.04630497
94Abnormal gallbladder morphology (HP:0012437)2.02936254
95* Abnormality of nucleobase metabolism (HP:0010932)2.02822614
96Lactic acidosis (HP:0003128)2.00192911
97Symptomatic seizures (HP:0011145)1.99924371
98Cholecystitis (HP:0001082)1.99639721
99Abnormal gallbladder physiology (HP:0012438)1.99639721
100Pancreatitis (HP:0001733)1.99295086
101Rimmed vacuoles (HP:0003805)1.98625282
102Abnormality of proline metabolism (HP:0010907)1.97682420
103Hydroxyprolinuria (HP:0003080)1.97682420
104Absence seizures (HP:0002121)1.96498944
105Methylmalonic acidemia (HP:0002912)1.96317109
106Hyperinsulinemic hypoglycemia (HP:0000825)1.95234757
107Lipid accumulation in hepatocytes (HP:0006561)1.95171366
108Alkalosis (HP:0001948)1.94889193
109Vascular calcification (HP:0004934)1.94776329
110Type 1 muscle fiber predominance (HP:0003803)1.94273116
111Hyperphosphaturia (HP:0003109)1.93623324
112Myotonia (HP:0002486)1.93216762
113Hemiparesis (HP:0001269)1.92704408
114Cerebral hypomyelination (HP:0006808)1.92188051
115X-linked dominant inheritance (HP:0001423)1.91416158
1163-Methylglutaconic aciduria (HP:0003535)1.91280044
117Amniotic constriction ring (HP:0009775)1.91179916
118Abnormality of placental membranes (HP:0011409)1.91179916
119Sensorimotor neuropathy (HP:0007141)1.89817071
120Myocardial infarction (HP:0001658)1.89428264
121Spontaneous abortion (HP:0005268)1.89042132
122Recurrent gram-negative bacterial infections (HP:0005420)1.88892932
123Increased serum lactate (HP:0002151)1.88103328
124Fetal akinesia sequence (HP:0001989)1.87612154
125Hypokinesia (HP:0002375)1.87212883
126Pheochromocytoma (HP:0002666)1.86750180
127Reduced antithrombin III activity (HP:0001976)1.86533744
128Abnormality of renal resorption (HP:0011038)1.85696308
129Amyloidosis (HP:0011034)1.85134182
130Irritability (HP:0000737)1.84916884
131EMG: myopathic abnormalities (HP:0003458)1.84912651
132Postural tremor (HP:0002174)1.84837608
133Enlarged kidneys (HP:0000105)1.83390883
134Optic disc pallor (HP:0000543)1.82351033
135Generalized tonic-clonic seizures (HP:0002069)1.82003188
136Type I transferrin isoform profile (HP:0003642)1.81051788
137Neoplasm of the peripheral nervous system (HP:0100007)1.80981751
138CNS demyelination (HP:0007305)1.80973481
139Increased muscle lipid content (HP:0009058)1.79935305
140Gait imbalance (HP:0002141)1.79260038
141Methylmalonic aciduria (HP:0012120)1.78624787
142Cholelithiasis (HP:0001081)1.78316633
143Rickets (HP:0002748)1.78144187
144Gout (HP:0001997)1.76654931
145Medial flaring of the eyebrow (HP:0010747)1.76228578
146Rhabdomyolysis (HP:0003201)1.75297130
147Anxiety (HP:0000739)1.73343809
148Left ventricular hypertrophy (HP:0001712)1.70361266
149Abnormality of the anterior horn cell (HP:0006802)1.69464839
150Degeneration of anterior horn cells (HP:0002398)1.69464839
151Delayed gross motor development (HP:0002194)1.69431733
152Hyporeflexia of lower limbs (HP:0002600)1.68948894
153Microglossia (HP:0000171)1.68906151
154Dialeptic seizures (HP:0011146)1.67674807
155Congenital primary aphakia (HP:0007707)1.64869917
156Diminished movement (HP:0002374)1.64638498
157Testicular atrophy (HP:0000029)1.60946060
158Limb-girdle muscle atrophy (HP:0003797)1.59999464
159Limb dystonia (HP:0002451)1.59607194
160Abnormality of the musculature of the pelvis (HP:0001469)1.59457771
161Abnormality of the hip-girdle musculature (HP:0001445)1.59457771
162Heart block (HP:0012722)1.58853808
163Poor suck (HP:0002033)1.58338822
164Neck muscle weakness (HP:0000467)1.58116075
165Neoplasm of the adrenal gland (HP:0100631)1.57998820
166Congenital malformation of the right heart (HP:0011723)1.57738485
167Double outlet right ventricle (HP:0001719)1.57738485
168Febrile seizures (HP:0002373)1.57228329
169Shoulder girdle muscle weakness (HP:0003547)1.56005319

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.62786902
2MAP3K123.54673476
3BCKDK2.92349521
4INSRR2.49260429
5PBK2.44827091
6PNCK2.36433565
7BCR2.24921203
8FRK2.21559026
9MST1R2.14016266
10TNIK2.11849520
11NEK12.08177568
12MAP2K42.06633281
13OXSR12.05506765
14TSSK62.03901566
15EIF2AK11.94004781
16EIF2AK31.91582240
17STK391.89422373
18VRK21.85421893
19TESK11.81681669
20PIK3CG1.80175476
21ERBB41.76765259
22BMPR1B1.62392579
23STK161.61530257
24MAP2K71.59420996
25MARK11.59276294
26MAP3K141.54405589
27CCNB11.53541055
28SCYL21.52962034
29BUB11.52626948
30IRAK31.46635001
31ERBB31.45033222
32SIK11.39400879
33BRSK11.37144691
34GRK51.36747352
35BMPR21.36463199
36CSNK1G21.35084951
37PLK31.34483026
38WEE11.33466544
39WNK41.29518016
40PAK31.28378062
41SRPK11.27461207
42TAOK31.27145664
43CSNK1G31.27002572
44ADRBK21.22701350
45BRSK21.21824396
46MYLK1.21475951
47STK38L1.20241640
48DAPK21.18846864
49IRAK21.16456784
50GRK71.16059001
51PAK61.15455652
52ARAF1.13828344
53MOS1.13327101
54MST41.12208099
55CSNK1G11.11397465
56CSNK1A1L1.09353111
57EPHA41.09143036
58ABL21.06545356
59NME11.06466732
60MUSK1.05498586
61PDK21.05428000
62IRAK11.05334455
63PIK3CA1.05211440
64MINK11.04087077
65SIK31.03532469
66NTRK31.02975573
67FGFR41.00847703
68PRPF4B0.98876003
69MAP3K90.96918375
70MAP3K40.96849071
71SGK4940.96520102
72SGK2230.96520102
73PRKCE0.94148716
74PINK10.92698136
75CAMK2G0.92246693
76DMPK0.88797611
77TTK0.88550438
78MAP3K130.88512868
79UHMK10.87455179
80CAMKK20.86004446
81MAP4K20.83033841
82PLK20.82379590
83NEK90.82212554
84ERN10.82064822
85MET0.81818956
86PKN10.81772344
87NEK60.81453085
88MAP3K110.80594423
89PRKCG0.80592748
90WNK30.80530889
91VRK10.78508953
92CAMK2A0.78471657
93MAPKAPK50.77967849
94PRKD30.77691223
95MAP3K20.75418163
96GRK10.74233032
97MAPK150.74137874
98FGR0.73522955
99PLK10.73267375
100AKT30.72801299
101NTRK20.71838347
102CDK80.71288122
103ROCK20.70943651
104ADRBK10.70819450
105TRIM280.70717039
106ILK0.69973594
107LATS20.69715005
108RIPK40.68231795
109DAPK10.65616425
110PRKCQ0.65134997
111CAMK2B0.65018675
112MAP2K10.64448944
113SGK20.60834779
114CAMK2D0.58807394
115CDK140.57751994
116MAPK120.57692479
117IRAK40.57411098
118MAPK40.56080782
119EPHB20.55564769
120CDK180.55506040
121MAPK130.55479020
122PAK40.54453335
123PRKACA0.53989674
124MAP2K60.53257710
125TYK20.52020433
126BRAF0.51686756
127CDK150.51609702
128FER0.51410632
129IKBKE0.50485349
130NUAK10.50015476
131PRKAA20.49759413
132CDK11A0.49224390
133PRKCZ0.48697278
134PRKACG0.48421186
135JAK10.48098864
136YES10.48025187
137PRKCA0.47395296
138ROCK10.46352023
139AKT20.45760628
140TIE10.45290541
141PRKG10.45113991
142CDK30.44499978
143LIMK10.44113734
144CDC70.43199423
145PLK40.43089251
146IGF1R0.42375302
147PHKG20.42314446
148PHKG10.42314446
149EIF2AK20.42249414
150OBSCN0.42153525
151LMTK20.41952404
152TEC0.41910146
153JAK20.41607707
154TBK10.41485917
155NTRK10.41451255
156CDK190.41262353

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.64154929
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.89688968
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.67440722
4Proteasome_Homo sapiens_hsa030502.58598327
5Fatty acid elongation_Homo sapiens_hsa000622.44013971
6Tryptophan metabolism_Homo sapiens_hsa003802.33606687
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33124689
8Histidine metabolism_Homo sapiens_hsa003402.30764234
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.29546911
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.29047859
11Butanoate metabolism_Homo sapiens_hsa006502.25642255
12Fatty acid degradation_Homo sapiens_hsa000712.25325327
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23893082
14Peroxisome_Homo sapiens_hsa041462.19345661
15Propanoate metabolism_Homo sapiens_hsa006402.18551474
16Arginine biosynthesis_Homo sapiens_hsa002202.17222629
17Steroid biosynthesis_Homo sapiens_hsa001002.12068043
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10418200
19Cardiac muscle contraction_Homo sapiens_hsa042602.09898303
20Complement and coagulation cascades_Homo sapiens_hsa046102.08682889
21Sulfur metabolism_Homo sapiens_hsa009202.06129000
22Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05777771
23Fatty acid metabolism_Homo sapiens_hsa012121.95850490
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.93641017
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93597918
26Chemical carcinogenesis_Homo sapiens_hsa052041.90490799
27Nitrogen metabolism_Homo sapiens_hsa009101.89309767
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87038791
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78686032
30PPAR signaling pathway_Homo sapiens_hsa033201.77615129
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76868835
32beta-Alanine metabolism_Homo sapiens_hsa004101.76555721
33Oxidative phosphorylation_Homo sapiens_hsa001901.75548227
34Phenylalanine metabolism_Homo sapiens_hsa003601.73651172
35Tyrosine metabolism_Homo sapiens_hsa003501.60351778
36Retinol metabolism_Homo sapiens_hsa008301.59965072
37Pyruvate metabolism_Homo sapiens_hsa006201.53579676
38Staphylococcus aureus infection_Homo sapiens_hsa051501.48079872
39Caffeine metabolism_Homo sapiens_hsa002321.38775047
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.35642407
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25769352
42RNA polymerase_Homo sapiens_hsa030201.23218996
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.19538454
44Parkinsons disease_Homo sapiens_hsa050121.15987892
45Starch and sucrose metabolism_Homo sapiens_hsa005001.13671172
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09042978
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05361144
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04399201
49Nucleotide excision repair_Homo sapiens_hsa034201.04398750
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03847077
51* Folate biosynthesis_Homo sapiens_hsa007901.03502161
52Bile secretion_Homo sapiens_hsa049761.03212213
53Alzheimers disease_Homo sapiens_hsa050101.00714477
54Mismatch repair_Homo sapiens_hsa034301.00005289
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99747248
56Ribosome_Homo sapiens_hsa030100.96679671
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95749461
58Insulin secretion_Homo sapiens_hsa049110.93784746
59Fat digestion and absorption_Homo sapiens_hsa049750.93323306
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93275154
61Arginine and proline metabolism_Homo sapiens_hsa003300.91923125
62Circadian rhythm_Homo sapiens_hsa047100.91490073
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90308695
64ABC transporters_Homo sapiens_hsa020100.89270019
65Oocyte meiosis_Homo sapiens_hsa041140.88962549
66Amphetamine addiction_Homo sapiens_hsa050310.88312647
67Vitamin digestion and absorption_Homo sapiens_hsa049770.87790282
68Carbon metabolism_Homo sapiens_hsa012000.87652464
69Glutathione metabolism_Homo sapiens_hsa004800.83741533
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80702980
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79249551
72Circadian entrainment_Homo sapiens_hsa047130.77794783
73Protein export_Homo sapiens_hsa030600.77682258
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.77174461
75RNA degradation_Homo sapiens_hsa030180.76818211
76Selenocompound metabolism_Homo sapiens_hsa004500.76123429
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75409834
78Dilated cardiomyopathy_Homo sapiens_hsa054140.74815429
79Collecting duct acid secretion_Homo sapiens_hsa049660.74790351
80Basal transcription factors_Homo sapiens_hsa030220.73092420
81Dopaminergic synapse_Homo sapiens_hsa047280.72307385
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72078428
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72016715
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70963212
85Purine metabolism_Homo sapiens_hsa002300.70702511
86One carbon pool by folate_Homo sapiens_hsa006700.69162158
87* Metabolic pathways_Homo sapiens_hsa011000.67497178
88Glycerolipid metabolism_Homo sapiens_hsa005610.64846651
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64425310
90Homologous recombination_Homo sapiens_hsa034400.64235027
91Pyrimidine metabolism_Homo sapiens_hsa002400.62645725
92Glutamatergic synapse_Homo sapiens_hsa047240.62273454
93Fatty acid biosynthesis_Homo sapiens_hsa000610.61662115
94Morphine addiction_Homo sapiens_hsa050320.58691171
95Huntingtons disease_Homo sapiens_hsa050160.57718039
96Vitamin B6 metabolism_Homo sapiens_hsa007500.57504211
97DNA replication_Homo sapiens_hsa030300.54992702
98Cocaine addiction_Homo sapiens_hsa050300.53919829
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53416715
100Glucagon signaling pathway_Homo sapiens_hsa049220.50179102
101Salivary secretion_Homo sapiens_hsa049700.48905187
102RNA transport_Homo sapiens_hsa030130.47856799
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47413743
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47218341
105Long-term potentiation_Homo sapiens_hsa047200.46803043
106Renin secretion_Homo sapiens_hsa049240.46705425
107Biosynthesis of amino acids_Homo sapiens_hsa012300.45527783
108Fanconi anemia pathway_Homo sapiens_hsa034600.42888705
109Linoleic acid metabolism_Homo sapiens_hsa005910.42643783
110Ether lipid metabolism_Homo sapiens_hsa005650.42078474
111Gastric acid secretion_Homo sapiens_hsa049710.40852084
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38591291
113Rheumatoid arthritis_Homo sapiens_hsa053230.36265014
114Vibrio cholerae infection_Homo sapiens_hsa051100.35716499
115* Sulfur relay system_Homo sapiens_hsa041220.34100166
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.32099802
117Pentose phosphate pathway_Homo sapiens_hsa000300.32032445
118Arachidonic acid metabolism_Homo sapiens_hsa005900.31618131
119African trypanosomiasis_Homo sapiens_hsa051430.31602128
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29859534
121Sphingolipid metabolism_Homo sapiens_hsa006000.29622224
122Prion diseases_Homo sapiens_hsa050200.29193853
123Lysine degradation_Homo sapiens_hsa003100.24210943
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21242330
125Galactose metabolism_Homo sapiens_hsa000520.20848223
126Phagosome_Homo sapiens_hsa041450.19469216
127Nicotine addiction_Homo sapiens_hsa050330.18717859
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17232513
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.15091918
130GABAergic synapse_Homo sapiens_hsa047270.14194451
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12700587
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12101014
133Synaptic vesicle cycle_Homo sapiens_hsa047210.12091282
134Ovarian steroidogenesis_Homo sapiens_hsa049130.10841211
135Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.10556821
136Serotonergic synapse_Homo sapiens_hsa047260.10136253
137Mineral absorption_Homo sapiens_hsa049780.09534639
138Regulation of autophagy_Homo sapiens_hsa041400.07618513
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06993833

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